No records
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519 |
Dannatt L., Ransing R., Calvey T., Scheibein F., Saad N.A., Shirasaka T., Ramalho R., Pant S., Vadivel R., Siste K., Stowe M.J., Kalita K.N., Boujraf S., Testa R., Arya S., Morgan N., Grandinetti P. |
57200537348;57190296865;55634512900;57212313904;57219875515;7005625709;56789745200;36114863900;57219874702;55644113100;57217388837;54387032200;57220277366;57222475193;35463222300;57201914207;55487378900; |
The Impact of Stigma on Treatment Services for People With Substance Use Disorders During the COVID-19 Pandemic—Perspectives of NECPAM Members |
2021 |
Frontiers in Psychiatry |
12 |
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634515 |
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5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102821643&doi=10.3389%2ffpsyt.2021.634515&partnerID=40&md5=f473eb1aa0aba07997e39ee4f82c800a |
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; Department of Psychiatry, Bhaktshreshtha Kamalakarpant Laxman (BKL) Walalwalkar Rural Medical College, Pune, India; Faculty of Health Sciences, School of Anatomical Sciences, University of the Witwatersrand, Johannesburg, South Africa; School of Health Science, Waterford Institute of Technology, Waterford, Ireland; State Drug Dependence Treatment Centre, Ain Shams University, Cairo, Egypt; Department of Psychiatry, Teine Keijinkai Medical Center, Sapporo, Japan; Department of Social and Community Health, School of Population Health, University of Auckland, Auckland, New Zealand; Department of Psychiatry, Institute of Medicine, Tribhuvan University, Kirtipur, Nepal; Department of Psychiatry, Medical Faculty, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Family Medicine, Faculty of Health Sciences, School of Medicine, University of Pretoria, Pretoria, South Africa; Department of Psychiatry, Lokopriya Gopinath Bordoloi Regional Institute of Mental Health (LGBRIMH), Tezpur, India; Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco; Department of Mental Health, Azienda Sanitaria Locale (ASL), 1 Avezzano-L'Aquila-Sulmona, L'Aquila, Italy; State Drug Dependence Treatment Centre, Institute of Mental Health, Pt. Bhagwat Dayal Sharma (BDS), University of Health Sciences, Rohtak, India; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Mental Helth, Azienda Sanitaria Locale (ASL) Teramo, Teramo, Italy |
Dannatt, L., Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; Ransing, R., Department of Psychiatry, Bhaktshreshtha Kamalakarpant Laxman (BKL) Walalwalkar Rural Medical College, Pune, India; Calvey, T., Faculty of Health Sciences, School of Anatomical Sciences, University of the Witwatersrand, Johannesburg, South Africa; Scheibein, F., School of Health Science, Waterford Institute of Technology, Waterford, Ireland; Saad, N.A., State Drug Dependence Treatment Centre, Ain Shams University, Cairo, Egypt; Shirasaka, T., Department of Psychiatry, Teine Keijinkai Medical Center, Sapporo, Japan; Ramalho, R., Department of Social and Community Health, School of Population Health, University of Auckland, Auckland, New Zealand; Pant, S., Department of Psychiatry, Institute of Medicine, Tribhuvan University, Kirtipur, Nepal; Vadivel, R.; Siste, K., Department of Psychiatry, Medical Faculty, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Stowe, M.J., Department of Family Medicine, Faculty of Health Sciences, School of Medicine, University of Pretoria, Pretoria, South Africa; Kalita, K.N., Department of Psychiatry, Lokopriya Gopinath Bordoloi Regional Institute of Mental Health (LGBRIMH), Tezpur, India; Boujraf, S., Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco; Testa, R., Department of Mental Health, Azienda Sanitaria Locale (ASL), 1 Avezzano-L'Aquila-Sulmona, L'Aquila, Italy; Arya, S., State Drug Dependence Treatment Centre, Institute of Mental Health, Pt. Bhagwat Dayal Sharma (BDS), University of Health Sciences, Rohtak, India; Morgan, N., Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Grandinetti, P., Department of Mental Helth, Azienda Sanitaria Locale (ASL) Teramo, Teramo, Italy |
[No abstract available] |
access to treatment; COVID-19; mental health; pandemic; stigma; substance use disorder |
benzodiazepine; naloxone; opiate agonist; Article; behavioral addiction; coronavirus disease 2019; drug dependence; drug dependence treatment; harm reduction; health care access; health care planning; health care policy; high risk population; homelessness; human; mental health care; pandemic; practice guideline; social discrimination; social distancing; stigma; vulnerable population |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
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562 |
Hanafi E., Siste K., Limawan A.P., Sen L.T., Christian H., Murtani B.J., Adrian, Siswidiani L.P., Suwartono C. |
56737010600;55644113100;57202712511;57219034101;57209266195;57216652176;57216932703;57219029296;15078359800; |
Alcohol- and Cigarette-Use Related Behaviors During Quarantine and Physical Distancing Amid COVID-19 in Indonesia |
2021 |
Frontiers in Psychiatry |
12 |
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622917 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100903075&doi=10.3389%2ffpsyt.2021.622917&partnerID=40&md5=eb7936d1479358e8922064492a38ba78 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia |
Hanafi, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Limawan, A.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sen, L.T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Christian, H., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Adrian, Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Siswidiani, L.P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suwartono, C., Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia |
Background: In light of the coronavirus disease 2019 (COVID-19) pandemic, Indonesia implemented large-scale social restrictions (pembatasan sosial berskala besar/PSBB) to combat the spread of COVID-19, which might influence addictive behaviors. The current study aimed to explore the fluctuation of substance use during the pandemic and association of physical distancing and related factors toward consumption of alcohol and cigarettes. Method: An online survey was conducted from April 28 to June 1, 2020. Data regarding sociodemographic information, physical distancing profile, alcohol and cigarette usages, Alcohol Use Disorders Identification Test (AUDIT), Cigarette Dependence Scale (CDS), Symptom Checklist-90, and Pittsburg Sleep Quality Index (PSQI) were collected. A total of 4,584 respondents from all 34 provinces in Indonesia completed the survey. Data were summarized descriptively and analyzed using chi-square, ANOVA, and multinomial regression on SPSS 23.0 for Windows. Results: This study found that during the COVID-19 pandemic in Indonesia alcohol consumption was 9.50% and daily cigarette smoking was 20.3%. Around 44.5% and 47.6% of respondents reported stable alcohol consumption and cigarette consumption, respectively. The mean AUDIT score was 3.52 ± 4.66 and the mean CDS score was 24.73 ± 8.86. Physical distancing was not correlated to any substance use changes. Increased alcohol consumption was negatively correlated with being unmarried and positively correlated with a higher PSQI score. Decreased alcohol use positively correlated with living in PSBB-implementing provinces and higher AUDIT scores when compared to stable alcohol drinking. Increased cigarette smoking was positively correlated with being male, unmarried, and higher CDS scores. Reduced cigarette smoking was negatively correlated with living in provinces implementing PSBB, higher CDS scores, and phobic anxiety, hostility, and psychoticism subscales of SCL-90. Discussion and Conclusion: The prevalence of alcohol and cigarette consumption changes showed a similar trend with other available studies in other countries. This study established that substance use was mainly sustained with a smaller proportion of respondents amplifying their substance usages. The changes were correlated with PSBB policy but not the practice of physical distancing. Psychiatry and addiction services in Indonesia should be strengthened to cope with the increased burden of psychological distress. Future studies should conduct more comparisons to determine whether the overall rising intensity of consumption was maintained post-pandemic and delineate acute psychopathologies' effects on substance use. © Copyright © 2021 Hanafi, Siste, Limawan, Sen, Christian, Murtani, Adrian, Siswidiani and Suwartono. |
alcohol; cigarette; large-scale social restriction; physical distancing; prevalence |
alcohol; addiction; adult; alcohol consumption; Alcohol Use Disorders Identification Test; alcoholism; analysis of variance; Article; chi square test; Cigarette Dependence Scale; cigarette smoking; controlled study; coronavirus disease 2019; demography; distress syndrome; drinking behavior; female; hostility; human; Indonesia; lockdown; major clinical study; male; mental disease; pandemic; phobia; Pittsburgh Sleep Quality Index; policy; prevalence; psychiatry; psychometry; psychosis; scoring system; sleep disorder; social distancing; social media; substance use; Symptom Checklist 90 |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
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No records
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753 |
Ocktariyana, Hikmawati N., Hestiantoro A., Muharam R., Marwali M.L., Surur A., Aninditha T., Pratama G., Zahrah A., Naura N.F., Asmarinah |
57210235127;55901590700;8743255100;57191492732;57204106005;57226169369;57189611205;57195959221;57205418186;57226137609;15820317600; |
Analysis of dna methylation level and mrna expression of transient receptor ankyrin member 1 (Trpa1) in endometriosis-associated pain |
2021 |
Asia-Pacific Journal of Molecular Biology and Biotechnology |
29 |
3 |
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1 |
10 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110656378&partnerID=40&md5=011cfc4031284fa4520681b99cc9b930 |
Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Human Reproductive, Infertility, and Family Planning Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Endometriosis Center, Fatmawati Hospital, Jakarta, Indonesia; Neurology Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Undergraduate Program in Biological Sciences, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jakarta, Indonesia; Medical Biology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Midwifery, Politeknik Kesehatan Palembang, Ministry of Health, Palembang, Indonesia |
Ocktariyana, Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Midwifery, Politeknik Kesehatan Palembang, Ministry of Health, Palembang, Indonesia; Hikmawati, N., Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hestiantoro, A., Human Reproductive, Infertility, and Family Planning Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Muharam, R., Human Reproductive, Infertility, and Family Planning Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Marwali, M.L., Endometriosis Center, Fatmawati Hospital, Jakarta, Indonesia; Surur, A., Endometriosis Center, Fatmawati Hospital, Jakarta, Indonesia; Aninditha, T., Neurology Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pratama, G., Human Reproductive, Infertility, and Family Planning Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Zahrah, A., Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Naura, N.F., Undergraduate Program in Biological Sciences, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Jakarta, Indonesia; Asmarinah, Human Reproductive, Infertility, and Family Planning Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Medical Biology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Transient Receptor Ankyrin Member 1 (TRPA1) is an ion channel family protein that regulates pain sensation through sensory neurons' activity. This study's purpose to analyzes the DNA methylation and mRNA expression level of the TRPA1 gene in endometriosis and its correlation with pain level. Twenty samples of peritoneal endometriosis and endometrial samples were obtained from women with endometriosis, which was subsequently compared to 20 endometrial samples of women without endometriosis. The DNA methylation level of TRPA1 was analyzed using Methylation-specific PCR (MS-PCR) and ImageJ software, while the mRNA expression of TRPA1 was analyzed using qRT-PCR. Furthermore, the pain level was measured using the numeric rating scale (NRS) by interviewing all the women. This study showed that there was a significant difference in the mRNA expression of TRPA1 in peritoneal endometriosis. The TRPA1 was unmethylated in both peritoneal and endometrial samples in endometriosis. However, DNA Methylation level of TRPA1 in peritoneal and endometrial of endometriosis compared to normal endometrial were no significant difference. Additionally, there was no correlation between DNA methylation level and mRNA expression level of TRPA1 in all samples, along with the endometriosis-associated pain. © 2021, University of Malaya. All rights reserved. |
DNA methylation; Endometriosis; MRNA expression; Pain; TRPA1 |
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University of Malaya |
01287451 |
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Article |
Q4 |
137 |
24544 |
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No records
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282 |
Lazarus G., Wangsaputra V.K., Christianto, Louisa M., Soetikno V., Hamers R.L. |
57214599425;57215576000;57223348000;41461551400;36769252100;23034345900; |
Safety and Pharmacokinetic Profiles of Long-Acting Injectable Antiretroviral Drugs for HIV-1 Pre-Exposure Prophylaxis: A Systematic Review and Meta-analysis of Randomized Trials |
2021 |
Frontiers in Pharmacology |
12 |
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664875 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111311631&doi=10.3389%2ffphar.2021.664875&partnerID=40&md5=708eaf175b9ad89a98ff6679c222f1c7 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom |
Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wangsaputra, V.K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Christianto, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soetikno, V., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hamers, R.L., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom |
Objectives: To investigate the safety and pharmacokinetic profiles of long-acting injectable pre-exposure prophylaxis (LAI PrEP), notably cabotegravir (CAB-LA) and rilpivirine (RPV-LA), for the prevention of human immunodeficiency virus-1 (HIV-1) infection. Methods: Eligible randomized trials of LAI PrEP in HIV-uninfected and/or healthy patients were included and assessed with the Revised Cochrane risk-of-bias tool for randomized trials. Where feasible, a meta-analysis was performed for safety outcomes by using a random-effects model with risk ratios and their 95% confidence intervals as the common effect measure. The protocol was registered with PROSPERO CRD42020154772. Results: Eight studies cumulating a total of 666 participants were included in this systematic review, including five (362 intervention-arm volunteers) and four trials (194 intervention-arm volunteers) that investigated CAB-LA and RPV-LA, respectively. We found that both CAB-LA and RPV-LA were generally well-tolerated as their safety profiles were similar to placebo in terms of any adverse event (AE), serious AE, and AE-related withdrawals. Furthermore, pharmacokinetic analyses revealed favorable prospects in viral inhibitory activity of CAB-LA and RPV-LA. Intramuscular (IM) injection of CAB-LA 600 mg Q8W was superior to CAB-LA 800 mg Q12W in male participants, while the same was true for RPV-LA 1200 mg IM Q8W over other dosing regimens. Although these results are promising, further research is required to confirm the findings on RPV-LA as current evidence is limited. Conclusion: CAB-LA and RPV-LA have promising safety and pharmacokinetic profiles. The preventive efficacy of these agents is being evaluated in Phase 3 trials. © Copyright © 2021 Lazarus, Wangsaputra, Christianto, Louisa, Soetikno and Hamers. |
cabotegravir; HIV-human immunodeficiency virus; long acting injectable (LAI); pre-exposure (PrEP) prophylaxis; rilpivirine |
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Frontiers Media S.A. |
16639812 |
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Review |
Q1 |
1384 |
2619 |
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604 |
Sandhiutami N.M.D., Arozal W., Louisa M., Rahmat D., Wuyung P.E. |
56692904000;32067462200;41461551400;36673726800;57192889605; |
Curcumin Nanoparticle Enhances the Anticancer Effect of Cisplatin by Inhibiting PI3K/AKT and JAK/STAT3 Pathway in Rat Ovarian Carcinoma Induced by DMBA |
2021 |
Frontiers in Pharmacology |
11 |
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603235 |
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10 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100565118&doi=10.3389%2ffphar.2020.603235&partnerID=40&md5=5b5af16fb791027b3a94b95b0b6da88b |
Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Animal Research Facility, Indonesian Medical Education and Research Institute, Jakarta, Indonesia |
Sandhiutami, N.M.D., Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Arozal, W., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmat, D., Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Wuyung, P.E., Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Animal Research Facility, Indonesian Medical Education and Research Institute, Jakarta, Indonesia |
Cisplatin has been used for decades for the treatment of ovarian cancer. However, despite its potent anticancer effect, cisplatin’s efficacy as a single agent was inadequate in patients with advanced stage. Curcumin has been shown to sensitize cisplatin activity in several cancer models. However, the low bioavailability of curcumin has limited its anticancer potential. Hence, nano-formulation of curcumin was developed to increase its therapeutic efficacy in ovarian cancer. The objective of this study was to investigate the mechanism of curcumin nanoparticles given in combination with cisplatin in rat ovarian carcinoma induced by dimethylbenz(a)anthracene (DMBA). The administration of cisplatin and nanocurcumin resulted in a significant reduction in ovarian tumor volume and weight. Furthermore, there were reduction in expressions of Ki67, TGF-β, PI3K, and Akt phosphorylation. Co-treatment of cisplatin and nanocurcumin also reduced JAK expression, STAT3 phosphorylation, and reduced IL-6 concentrations. Altogether, nanocurcumin, given as a co-treatment with cisplatin has therapeutic potential in ovarian cancer models by inhibiting proliferation through downregulation of PI3K/Akt and JAK/STAT3 signaling pathways. © Copyright © 2021 Sandhiutami, Arozal, Louisa, Rahmat and Wuyung. |
cisplatin; curcumin; interleukin-6; nanoparticles; ovarian carcinoma; TGF-β |
cisplatin; curcumin; dimethylbenz[a]anthracene; interleukin 6; Janus kinase; Ki 67 antigen; nanoparticle; phosphatidylinositol 3 kinase; protein kinase B; STAT3 protein; transforming growth factor beta; animal cell; animal experiment; animal model; animal tissue; antineoplastic activity; Article; biological model; cell proliferation; controlled study; down regulation; drug efficacy; enzyme inhibition; female; JAK-STAT signaling; nonhuman; ovary carcinoma; Pi3K/Akt signaling; protein expression; protein phosphorylation; rat; tumor volume; tumor weight |
Frontiers Media S.A. |
16639812 |
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Article |
Q1 |
1384 |
2619 |
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No records
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6 |
Pranata R., Huang I., Lim M.A., Yonas E., Vania R., Lukito A.A., Nasution S.A., Siswanto B.B., Kuswardhani R.A.T. |
57201973901;57208576645;57216039756;57201987097;57208328436;57213835420;57189373134;14422648800;36863900500; |
Elevated De Ritis Ratio Is Associated With Poor Prognosis in COVID-19: A Systematic Review and Meta-Analysis |
2021 |
Frontiers in Medicine |
8 |
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676581 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122327729&doi=10.3389%2ffmed.2021.676581&partnerID=40&md5=254957cc5c17b448a803a88e33741d8f |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Faculty of Medicine, Department of Internal Medicine, Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Faculty of Medicine, Division of Plastic, Reconstructive, and Aesthetic, Department of Surgery, Sanglah General Hospital, Udayana University, Jimbaran, Indonesia; Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Faculty of Medicine, Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Division of Geriatrics, Department of Internal Medicine, Sanglah Teaching Hospital, Udayana University, Denpasar, Indonesia |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Huang, I., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Faculty of Medicine, Department of Internal Medicine, Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Faculty of Medicine, Division of Plastic, Reconstructive, and Aesthetic, Department of Surgery, Sanglah General Hospital, Udayana University, Jimbaran, Indonesia; Lukito, A.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Nasution, S.A., Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siswanto, B.B., Faculty of Medicine, Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia, Jakarta, Indonesia; Kuswardhani, R.A.T., Faculty of Medicine, Division of Geriatrics, Department of Internal Medicine, Sanglah Teaching Hospital, Udayana University, Denpasar, Indonesia |
Objective: This meta-analysis aims to assess whether elevated De Ritis ratio is associated with poor prognosis in patients with coronavirus 2019 (COVID-19). Methods: A systematic literature search was performed using PubMed, Embase, and EuropePMC databases up until September 17, 2021. De Ritis ratio is also known as Aspartate aminotransferase/alanine transaminase (AST/ALT) ratio. The main outcome was poor prognosis, a composite of mortality, severity, the need for ICU care, and intubation. The effect measure was odds ratios (ORs) and mean differences. We generated sensitivity and specificity, negative and positive likelihood ratio (NLR and PLR), diagnostic odds ratio (DOR), and area under curve (AUC). Results: There were eight studies with 4,606 patients. De Ritis ratio was elevated in 44% of the patients. Patients with poor prognosis have higher De Ritis ratio [mean difference 0.41 (0.31, 0.50), p < 0.001; I2: 81.0%] and subgroup analysis showed that non-survivors also have higher De Ritis Ratio [mean difference 0.47 (0.46, 0.48), p < 0.001; I2: 0%]. Elevated De Ritis ratio was associated with poor prognosis [OR 3.28 (2.39, 4.52), p < 0.001; I2: 35.8%]. It has a sensitivity of 55% (36–73), specificity of 71% (52–85), PLR 1.9, NLR.63, DOR of 3 (2–4), and AUC of.67 (0.63–0.71). The posterior probability of poor prognosis was 38% if De Ritis is elevated, while 17% if De Ritis is not elevated. Conclusion: Elevated De Ritis ratio is associated with poor prognosis in patients with COVID-19. Systematic Review Registration: PROSPERO ID: CRD42020216634. Copyright © 2021 Pranata, Huang, Lim, Yonas, Vania, Lukito, Nasution, Siswanto and Kuswardhani. |
coronavirus—COVID-19; De Ritis ratio; liver enzyme; SARS-CoV-2; transaminase |
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Frontiers Media S.A. |
2296858X |
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Review |
Q1 |
1388 |
2608 |
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223 |
Razeghian E., Margiana R., Chupradit S., Bokov D.O., Abdelbasset W.K., Marofi F., Shariatzadeh S., Tosan F., Jarahian M. |
57223052224;56685900600;57211329338;56845561300;57208873763;57199650994;57225946579;57216155951;16241593900; |
Mesenchymal Stem/Stromal Cells as a Vehicle for Cytokine Delivery: An Emerging Approach for Tumor Immunotherapy |
2021 |
Frontiers in Medicine |
8 |
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721174 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114747651&doi=10.3389%2ffmed.2021.721174&partnerID=40&md5=eb488365f37edbafb0ec0a51d29dbfc9 |
Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology (NIGEB), Tehran, Iran; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia; Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand; Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation; Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran; Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany |
Razeghian, E., Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology (NIGEB), Tehran, Iran; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia, Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Chupradit, S., Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand; Bokov, D.O., Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation, Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation; Abdelbasset, W.K., Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Marofi, F., Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Shariatzadeh, S., Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Tosan, F., Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran; Jarahian, M., Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany |
Pro-inflammatory cytokines can effectively be used for tumor immunotherapy, affecting every step of the tumor immunity cycle. Thereby, they can restore antigen priming, improve the effector immune cell frequencies in the tumor microenvironment (TME), and eventually strengthen their cytolytic function. A renewed interest in the anticancer competencies of cytokines has resulted in a substantial promotion in the number of trials to address the safety and efficacy of cytokine-based therapeutic options. However, low response rate along with the high toxicity associated with high-dose cytokine for reaching desired therapeutic outcomes negatively affect their clinical utility. Recently, mesenchymal stem/stromal cells (MSCs) due to their pronounced tropism to tumors and also lower immunogenicity have become a promising vehicle for cytokine delivery for human malignancies. MSC-based delivery of the cytokine can lead to the more effective immune cell-induced antitumor response and provide sustained release of target cytokines, as widely evidenced in a myriad of xenograft models. In the current review, we offer a summary of the novel trends in cytokine immunotherapy using MSCs as a potent and encouraging carrier for antitumor cytokines, focusing on the last two decades' animal reports. © Copyright © 2021 Razeghian, Margiana, Chupradit, Bokov, Abdelbasset, Marofi, Shariatzadeh, Tosan and Jarahian. |
cytokine; cytokine delivery; gene therapy; mesenchymal stem/stromal cells; tumor-immunotherapy |
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Reksodiputro M.H., Harahap A.R., Setiawan L., Yosia M. |
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A Modified Preparation Method of Ideal Platelet-Rich Fibrin Matrix From Whole Blood |
2021 |
Frontiers in Medicine |
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724488 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114628863&doi=10.3389%2ffmed.2021.724488&partnerID=40&md5=2a784dc8d442d97efac9d34d1c6769cc |
Division of Facial Plastic & Reconstructive Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Rumah Sakit Dharmais Pusat Kanker Nasional, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Reksodiputro, M.H., Division of Facial Plastic & Reconstructive Surgery, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harahap, A.R., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Setiawan, L., Department of Clinical Pathology, Rumah Sakit Dharmais Pusat Kanker Nasional, Jakarta, Indonesia; Yosia, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
One bioproduct that is widely used in the wound healing process is platelet-rich plasma (PRP). PRP is a liquid solution with high autologous platelet concentration, making it a good source of growth factors to accelerate wound healing. Recent development in PRP had created a new product called platelet-rich fibrin matrix (PRFM), which has a denser and more flexible structure. PRFM is the newest generation of platelet concentrate with a fibrin matrix that holds platelet in it. The key concept in creating PRFM from PRP is the addition of CaCl2 followed by centrifugation, which converts fibrinogen to fibrin, and the fibrin cross-links to form a matrix that contains viable platelets. There are many commercially available kits to create PRFM, but they are often expensive and uneconomical. This research will test a modified method of making ideal PRFM from PRP without any commercial kits. The modified method will include determining the minimum level of CaCl2 used, the type of centrifuge, and the speed and duration of centrifugation. By performing a modified preparation method on five samples of whole blood, it was found that the ideal PRFM could be made by mixing PRP with 25 mM CaCl2 and centrifuging it at a speed of 2,264 × g for 25 min at room temperature. The PRP and PRFM platelet counts of this method tend to be lower than the platelet counts found in other studies. Although visually comparable, further study is needed to compare the performance of PRFMs made with this method and PRFMs made with commercial kits. © Copyright © 2021 Reksodiputro, Harahap, Setiawan and Yosia. |
CaCl2; centrifugation; fibrin matrix; platelet concentrate; platelet rich fibrin matrix; platelet rich plasma |
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Setiati S., Soejono C.H., Harimurti K., Dwimartutie N., Aryana I.G.P.S., Sunarti S., Budiningsih F., Mulyana R., Dwipa L., Sudarso A., Rensa R., Istanti R., Azwar M.K., Marsigit J. |
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Frailty and Its Associated Risk Factors: First Phase Analysis of Multicentre Indonesia Longitudinal Aging Study |
2021 |
Frontiers in Medicine |
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658580 |
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Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Udayana, Bali, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Solo, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Hasanuddin, Makasar, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Atma Jaya, Jakarta, Indonesia |
Setiati, S., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia, Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Soejono, C.H., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Harimurti, K., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia, Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Dwimartutie, N., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Aryana, I.G.P.S., Department of Internal Medicine, Faculty of Medicine, Universitas Udayana, Bali, Indonesia; Sunarti, S., Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Budiningsih, F., Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Solo, Indonesia; Mulyana, R., Department of Internal Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Dwipa, L., Department of Internal Medicine, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Sudarso, A., Department of Internal Medicine, Faculty of Medicine, Universitas Hasanuddin, Makasar, Indonesia; Rensa, R., Department of Internal Medicine, Faculty of Medicine, Universitas Atma Jaya, Jakarta, Indonesia; Istanti, R., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Azwar, M.K., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Marsigit, J., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background: National long-term care development requires updated epidemiological data related to frailty. We aimed to find the prevalence of frailty and its associated factors among Indonesian elderly. Methods: We conducted first-phase cross-sectional analysis of Indonesia Longitudinal Aging Study (INALAS) data collected from community-dwelling outpatients aged 60 years and older without acute illness in nine geriatric service care centres. Descriptive, bivariate and multivariate analyses were conducted. Results: Among 908 elderly in this study, 15.10% were robust, 66.20% were pre-frail, and 18.70% were frail. Functional dependence was associated with frailty among Indonesian elderly (OR 5.97, 95% CI 4.04–8.80). Being depressed and at risk for malnutrition were also associated with frailty with OR 2.54, 95% CI 1.56–4.12, and OR 2.56, 95% CI 1.68–3.90, respectively. Prior history of fall (OR 1.77, 95% CI 1.16–2.72) and hospitalization (OR 1.46, 95% CI 0.97–2.20) in the previous 12 months were associated with frailty. There is also significant association between poly pharmacy and frailty (OR 2.42, 95% CI 1.50–3.91). Conclusion: Approximately one in five Indonesian community-dwelling elderly was frail. Frailty is associated with functional dependence, being at risk for malnutrition or being malnourished, depression, history of fall, history of hospitalization, and poly pharmacy. There may be bidirectional relationships between the risk factors and frailty. The development of long-term care in Indonesia should be considered, without forcing the elderly who need it. © Copyright © 2021 Setiati, Soejono, Harimurti, Dwimartutie, Aryana, Sunarti, Budiningsih, Mulyana, Dwipa, Sudarso, Rensa, Istanti, Azwar and Marsigit. |
community-dwelling elderly; frailty; Indonesia; long-term care; prevalence; risk factors |
adult; aged; aging; Article; community dwelling person; cross-sectional study; depression; falling; female; frailty; functional status; high risk population; hospitalization; human; Indonesian; longitudinal study; major clinical study; male; malnutrition; medical history; outpatient; polypharmacy; prevalence; risk factor |
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