No records
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72 |
Fitriana I., Setiati S., Rizal E.W., Istanti R., Rinaldi I., Kojima T., Akishita M., Azwar M.K. |
55486095900;14325991900;57223021639;23496653300;23475122400;55240575700;7004867426;57202798959; |
Malnutrition and depression as predictors for 30-day unplanned readmission in older patient: a prospective cohort study to develop 7-point scoring system |
2021 |
BMC Geriatrics |
21 |
1 |
256 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104539861&doi=10.1186%2fs12877-021-02198-7&partnerID=40&md5=38aa06ca8c7777764cff2096359b93e7 |
Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Clinical Epidemiology and Evidence Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan |
Fitriana, I., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Setiati, S., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia, Clinical Epidemiology and Evidence Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rizal, E.W., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Istanti, R., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Rinaldi, I., Clinical Epidemiology and Evidence Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kojima, T., Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Akishita, M., Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Azwar, M.K., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia |
Background: Readmission is related to high cost, high burden, and high risk for mortality in geriatric patients. A scoring system can be developed to predict the readmission of older inpatients to perform earlier interventions and prevent readmission. Methods: We followed prospectively inpatients aged 60 years and older for 30 days, with initial comprehensive geriatric assessment (CGA) on admission in a tertiary referral centre. Patients were assessed with CGA tools consisting of FRAIL scale (fatigue, resistance, ambulation, illness, loss of weight), the 15-item Geriatric Depression Scale, Mini Nutritional Assessment short-form (MNA-SF), the Barthel index for activities of daily living (ADL), Charlson Comorbidity Index (CCI), caregiver burden based on 4-item Zarit Burden Index (ZBI), and cognitive problem with Abbreviated Mental Test (AMT). Demographic data, malignancy diagnosis, and number of drugs were also recorded. We excluded data of deceased patients and patients transferred to other hospitals. We conducted stepwise multivariate regression analysis to develop the scoring system. Results: Thirty-day unplanned readmission rate was 37.6 %. Among 266 patients, 64.7 % of them were malnourished, and 46.5 % of them were readmitted. About 24 % were at risk for depression or having depressed mood, and 53.1 % of them were readmitted. In multivariate analysis, nutritional status (OR 2.152, 95 %CI 1.151–4.024), depression status (OR 1.884, 95 %CI 1.071–3.314), malignancy (OR 1.863 95 %CI 1.005–3.451), and functional status (OR 1.584, 95 %CI 0.885–2.835) were included in derivation of 7 score system. The scoring system had maximum score of 7 and incorporated malnutrition (2 points), depression (2 points), malignancy (2 points), and dependent functional status (1 point). A score of 3 or higher suggested 82 % probability of readmission within 30 days following discharge. Area under the curve (AUC) was 0.694 (p = 0.001). Conclusions: Malnutrition, depression, malignancy and functional problem are predictors for 30-day readmission. A practical CGA-based 7 scoring system had moderate accuracy and strong calibration in predicting 30-day unplanned readmission for older patients. © 2021, The Author(s). |
Comprehensive geriatric assessment; Depression; Malnutrition; Predictive score; Readmission |
aged; daily life activity; depression; geriatric assessment; hospital readmission; human; malnutrition; middle aged; nutritional assessment; nutritional status; prospective study; risk factor; Activities of Daily Living; Aged; Depression; Geriatric Assessment; Humans; Malnutrition; Middle Aged; Nutrition Assessment; Nutritional Status; Patient Readmission; Prospective Studies; Risk Factors |
BioMed Central Ltd |
14712318 |
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33865312 |
Article |
Q1 |
1414 |
2506 |
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No records
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150 |
Basrowi R.W., Rahayu E.M., Khoe L.C., Wasito E., Sundjaya T. |
57024210400;57275241200;56586245200;6506940239;57188810826; |
The road to healthy ageing: What has indonesia achieved so far? |
2021 |
Nutrients |
13 |
10 |
3441 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115825022&doi=10.3390%2fnu13103441&partnerID=40&md5=71597249210e18c8c5775dcf67e18dbe |
Occupational Medicine Division, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Medical and Science Affairs Division, Danone Specialized Nutrition Indonesia, Jakarta, 12950, Indonesia; Department of Anthropology, Faculty of Social and Political Science Universitas Indonesia, Depok, 16424, Indonesia; Laboratorium Political Psychology, Faculty of Psychology Universitas Indonesia, Depok, 16424, Indonesia |
Basrowi, R.W., Occupational Medicine Division, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Medical and Science Affairs Division, Danone Specialized Nutrition Indonesia, Jakarta, 12950, Indonesia; Rahayu, E.M., Department of Anthropology, Faculty of Social and Political Science Universitas Indonesia, Depok, 16424, Indonesia, Laboratorium Political Psychology, Faculty of Psychology Universitas Indonesia, Depok, 16424, Indonesia; Khoe, L.C., Occupational Medicine Division, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Wasito, E., Medical and Science Affairs Division, Danone Specialized Nutrition Indonesia, Jakarta, 12950, Indonesia; Sundjaya, T., Medical and Science Affairs Division, Danone Specialized Nutrition Indonesia, Jakarta, 12950, Indonesia |
The World Health Organization (WHO) has projected that the world should prepare for an aging society. As the fourth most populous country in the world, the elderly population in Indonesia is also continuously growing. In 2010, the proportion of the elderly group was merely 5%, and it is expected to increase to 11% in 2035. Understanding the current situation of the adult population in Indonesia would be crucial to prepare for the future aging population. This article analyzed the current socio-demographic status, nutrition status, nutrient intake, and health profile of the current Indonesian adult population through a literature review. The key issues to prepare for healthy aging in Indonesia are summarized. Acknowledging the profile of the adult and senior adult population in Indonesia will provide beneficial information for all stakeholders in preparing Indonesia for a better healthy aging population with improved quality of life. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Aging population; Demographic; Health profile; Healthy ageing; Nutritional status |
adult; aged; demography; female; healthy aging; human; human experiment; Indonesia; Indonesian; male; nutrient intake; nutritional status; quality of life; review; World Health Organization; epidemiology; health status; health survey; Indonesia; nutritional status; socioeconomics; Health Status; Healthy Aging; Humans; Indonesia; Nutritional Status; Public Health Surveillance; Quality of Life; Socioeconomic Factors |
MDPI |
20726643 |
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34684441 |
Review |
Q1 |
1418 |
2497 |
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211 |
Angelin T.C., Bardosono S., Shinta D., Fahmida U. |
57235777300;21933841000;57237520500;14420783500; |
Growth, dietary intake, and vitamin D receptor (VDR) promoter genotype in Indonesian school-age children |
2021 |
Nutrients |
13 |
9 |
2904 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113740878&doi=10.3390%2fnu13092904&partnerID=40&md5=c7a37360e57bb2d193a5b68571b677d7 |
Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia |
Angelin, T.C., Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional, Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Nutrition, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Shinta, D., Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional, Universitas Indonesia, Jakarta, 10430, Indonesia; Fahmida, U., Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional, Universitas Indonesia, Jakarta, 10430, Indonesia |
Nutrition has been known as a predominant factor associated with stunting. However, some studies have discovered a genetic contribution in calcium absorption that will affect growth, known as the VDR gene. The aim of this study was to assess the association between VDR gene polymorphism and dietary intake towards height-for-age z-score (HAZ) of elementary school children in Malang District, East Java. This study analyzed the baseline of a randomized trial in East Java, Indonesia. School children aged 8–10 years old (n = 142) were included in this study. Energy, protein, calcium, and vitamin D intakes were obtained using 4-day 24-h dietary recalls. Two SNPs located in the promoter region of VDR gene were selected (rs11568820 and rs4516035) and analyzed using Real-Time PCR. The result showed a significant correlation between energy and protein intake with HAZ of the children (p = 0.030 and p = 0.016, respectively). The association between VDR gene and HAZ was not found (p > 0.05). Adjusted by other factors, protein intake was significantly correlated with HAZ (β = 0.034, 95% CI 0.015–0.052, p < 0.001, adj. R2 = 0.089). The children in our study had a favorable VDR gene genotype, however the effect of VDR gene promoter activity might not be revealed due to very low vitamin D and calcium intake to stimulate intestinal calcium absorption which in turn affects HAZ. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Calcium; Children; Dietary intake; Height-for-age z-score (HAZ); Indonesia; Stunting; VDR gene; Vitamin D |
calcium; DNA; protein; vitamin D; vitamin D receptor; calcitriol receptor; vitamin D; Article; body height; calcium absorption; calcium intake; caloric intake; child; child growth; controlled study; correlational study; cross-sectional study; diarrhea; dietary intake; elementary student; female; food frequency questionnaire; gene frequency; genetic variability; genotype; helminthiasis; heterozygote; human; Indonesia; macronutrient intake; male; micronutrient intake; pathogenesis; prevalence; primary school; promoter region; protein intake; randomized controlled trial; real time polymerase chain reaction; respiratory tract infection; school child; semi quantitative food frequency questionnaire; single nucleotide polymorphism; stunting; sun exposure; sunlight; vitamin intake; administration |
MDPI |
20726643 |
|
34578782 |
Article |
Q1 |
1418 |
2497 |
|
|
311 |
Sunardi D., Bardosono S., Basrowi R.W., Wasito E., Vandenplas Y. |
57192075078;21933841000;57024210400;6506940239;57223670656; |
Dietary determinants of anemia in children aged 6–36 months: A cross-sectional study in Indonesia |
2021 |
Nutrients |
13 |
7 |
2397 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109524537&doi=10.3390%2fnu13072397&partnerID=40&md5=2e8ac565ce8b6f3dd3f70a2de509a9ad |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Vrije Universiteit Brussel (VUB), UZ Brussels, KidZ Health Castle, Brussels, 1090, Belgium |
Sunardi, D., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Basrowi, R.W., Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Wasito, E., Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Vandenplas, Y., Vrije Universiteit Brussel (VUB), UZ Brussels, KidZ Health Castle, Brussels, 1090, Belgium |
Anemia has been acknowledged as worldwide problem, including in Indonesia. This cross-sectional study aims to explore dietary determinants as risk factors for anemia in children aged 6–36 months living in a poor urban area of Jakarta. The study was done in Kampung Melayu sub-district in Jakarta, Indonesia. Data was collected within two weeks in September–October 2020. A structured questionnaire for a 24-h recall and a semi-quantitative Food Frequency Questionnaire (FFQ) were used to collect the dietary intake data, and venous blood was withdrawn to determine the hemoglobin levels. Bivariate chi-square and multiple logistic regression tests were executed to explore the dietary determinant factors for anemia. We recruited 180 subjects. The average hemoglobin concentration was 11.4 ± 1.7 mg/dL; the anemia prevalence was 29.4%. The following variables were significantly associated with higher risk of anemia: no cow’s milk formula consumption, inadequate intake of fats, protein, calcium, vitamin D, iron, zinc, vitamin A, vitamin C, vitamin B6, and vitamin B12. Only cow’s milk formula consumption and zinc intake were revealed as the determinant factors of anemia. In conclusion, the prevalence of anemia was 29.4% among children aged 6–36 months old. Anemia was significantly associated with two dietary determinants as risk factors that are cow’s milk formula consumption and zinc intake. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Anemia; Cow’s milk; Cow’s milk formula; Indonesia; Toddler; Zinc |
biological marker; hemoglobin; zinc; adverse event; age; anemia; artificial milk; blood; bottle feeding; cross-sectional study; diet; female; human; Indonesia; infant; infant nutrition; male; metabolism; nutritional status; pathophysiology; preschool child; prevalence; risk assessment; risk factor; urban health; Age Factors; Anemia; Biomarkers; Bottle Feeding; Child, Preschool; Cross-Sectional Studies; Diet; Diet Surveys; Female; Hemoglobins; Humans; Indonesia; Infant; Infant Formula; Infant Nutritional Physiological Phenomena; Male; Nutritional Status; Prevalence; Risk Assessment; Risk Factors; Urban Health; Zinc |
MDPI AG |
20726643 |
|
34371908 |
Article |
Q1 |
1418 |
2497 |
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|
901 |
Kadosh K.C., Muhardi L., Parikh P., Basso M., Mohamed H.J.J., Prawitasari T., Samuel F., Ma G., Geurts J.M.W. |
12243251700;57216729101;35269493300;57221482131;41861368100;57190686255;14421774000;57199673360;57197926057; |
Nutritional support of neurodevelopment and cognitive function in infants and young children—an update and novel insights |
2021 |
Nutrients |
13 |
1 |
199 |
1 |
26 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099415887&doi=10.3390%2fnu13010199&partnerID=40&md5=9754b1ffd94e454fc9ae27ba058537af |
School of Psychology, University of Surrey, Guildford, GU2 7XH, United Kingdom; FrieslandCampina AMEA, Singapore, 039190, Singapore; Department of General Psychology, University of Padova, Padova, 35131, Italy; Nutrition and Dietetics Programme, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Malaysia; Nutrition and Metabolic Diseases Working Group, Indonesian Pediatric Society, Jakarta, 10310, Indonesia; Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusomo National Referral Hospital Jakarta, Jakarta, 10430, Indonesia; Department of Human Nutrition, University of Ibadan, Ibadan, 200284, Nigeria; Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 10019, China; Laboratory of Toxicological Research and Risk assessment for Food Safety, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191, China; FrieslandCampina, Amersfoort, 3818 LE, Netherlands |
Kadosh, K.C., School of Psychology, University of Surrey, Guildford, GU2 7XH, United Kingdom; Muhardi, L., FrieslandCampina AMEA, Singapore, 039190, Singapore; Parikh, P., FrieslandCampina AMEA, Singapore, 039190, Singapore; Basso, M., School of Psychology, University of Surrey, Guildford, GU2 7XH, United Kingdom, Department of General Psychology, University of Padova, Padova, 35131, Italy; Mohamed, H.J.J., Nutrition and Dietetics Programme, School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Malaysia; Prawitasari, T., Nutrition and Metabolic Diseases Working Group, Indonesian Pediatric Society, Jakarta, 10310, Indonesia, Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusomo National Referral Hospital Jakarta, Jakarta, 10430, Indonesia; Samuel, F., Department of Human Nutrition, University of Ibadan, Ibadan, 200284, Nigeria; Ma, G., Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 10019, China, Laboratory of Toxicological Research and Risk assessment for Food Safety, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, 100191, China; Geurts, J.M.W., FrieslandCampina, Amersfoort, 3818 LE, Netherlands |
Proper nutrition is crucial for normal brain and neurocognitive development. Failure to optimize neurodevelopment early in life can have profound long-term implications for both mental health and quality of life. Although the first 1000 days of life represent the most critical period of neurodevelopment, the central and peripheral nervous systems continue to develop and change throughout life. All this time, development and functioning depend on many factors, including adequate nutrition. In this review, we outline the role of nutrients in cognitive, emotional, and neural development in infants and young children with special attention to the emerging roles of polar lipids and high quality (available) protein. Furthermore, we discuss the dynamic nature of the gut-brain axis and the importance of microbial diversity in relation to a variety of outcomes, including brain maturation/function and behavior are discussed. Finally, the promising therapeutic potential of psychobiotics to modify gut microbial ecology in order to improve mental well-being is presented. Here, we show that the individual contribution of nutrients, their interaction with other micro-and macronutrients and the way in which they are organized in the food matrix are of crucial importance for normal neurocognitive development. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Brain; Childhood; Gut-brain axis; Kynurenine; Minerals; Neurodevelopment; Polar lipids; Polyunsaturated fatty acids; Prebiotics; Probiotics; Protein quality; Tryptophan; Tyrosine; Vitamins |
amino acid; branched chain amino acid; cyanocobalamin; iodine; iron; lipid; long chain fatty acid; mammalian target of rapamycin complex 1; phenylalanine; polar lipid; polyunsaturated fatty acid; prebiotic agent; probiotic agent; retinol; trace element; tryptophan; tyrosine; unclassified drug; vitamin D; zinc; fatty acid; kynurenine; mineral; brain development; child; cognition; emotion; human; infant; infant nutrition; intestine flora; macronutrient; nerve cell differentiation; nonhuman; nutritional support; protein intake; protein quality; Review; brain; cognitive aging; food; growth, development and aging; preschool child; quality of life; Brain; Child, Preschool; Cognition; Cognitive Aging; Emotions; Fatty Acids; Food; Gastrointestinal Microbiome; Humans; Infant; Kynurenine; Minerals; |
MDPI AG |
20726643 |
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33435231 |
Review |
Q1 |
1418 |
2497 |
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No records
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193 |
Putrantyo I.I., Mosahebi A., Smith O., de Vega B. |
57268843400;55985666400;54881691700;57222467939; |
Investigating Effectiveness of Topical Autologous Platelet-rich Plasma as Prophylaxis to Prevent Wound Infection: A Systematic Review and Meta-analysis |
2021 |
Malaysian Journal of Medicine and Health Sciences |
17 |
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72 |
82 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117073627&partnerID=40&md5=e2542cf5f0470226375c2d3b9af84e52 |
Division of Surgery and Interventional Science, University College London, Royal Free Hospital, London, NW3 2QG, United Kingdom; Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta Pusat, 10430, Indonesia; Cell and Tissue Bank-Regenerative Medicine Center, Dr Soetomo General Hospital, Surabaya, 60286, Indonesia |
Putrantyo, I.I., Division of Surgery and Interventional Science, University College London, Royal Free Hospital, London, NW3 2QG, United Kingdom, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta Pusat, 10430, Indonesia; Mosahebi, A., Division of Surgery and Interventional Science, University College London, Royal Free Hospital, London, NW3 2QG, United Kingdom; Smith, O., Division of Surgery and Interventional Science, University College London, Royal Free Hospital, London, NW3 2QG, United Kingdom; de Vega, B., Division of Surgery and Interventional Science, University College London, Royal Free Hospital, London, NW3 2QG, United Kingdom, Cell and Tissue Bank-Regenerative Medicine Center, Dr Soetomo General Hospital, Surabaya, 60286, Indonesia |
Autologous platelet-rich plasma (PRP) was reported as having potent antimicrobial properties. However, the literature showed conflicting results. Therefore, we aim to investigate the effectiveness of topical autologous PRP as prophylaxis to prevent wound infection. We searched major electronic databases such as MEDLINE, EMBASE, CENTRAL, and Web of Science to identify RCT studies regarding this topic. The selection of included studies followed the PRISMA guidelines. We included ten RCTs comprising 1257 participants. In general, PRP showed no effect in reducing the risk of wound infection (RR: 0.84; 95% CI: 0.66–1.06; p=0.14). However, subgroup analysis based on wound characteristic showed that PRP significantly reduced wound infection risks in acute wounds (RR: 0.76; 95% CI: 0.58–0.99; p=0.04). Meanwhile, activation of PRP had no effect in reducing wound infection risks (p=0.77). In conclusion, we suggest routine autologous topical PRP application in acute wound care due to PRP antimicrobial properties and regenerative potential. © 2021 UPM Press. All rights reserved. |
Antimicrobial agent; Platelet-rich plasma; Systematic review; Topical administration; Wound infection |
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Universiti Putra Malaysia Press |
16758544 |
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Review |
Q4 |
144 |
23823 |
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464 |
Cahyono A.T., Louisa M., Mayang Permata T.B., Handoko, Nuryadi E., Kodrat H., Wibowo H., Hariandy Hamid A.R.A., Sekarutami S.M., Gondhowiardjo S.A. |
57222900545;41461551400;57197808751;57209984822;57197806814;57210639849;57217690943;57202054669;56576294500;6508327402; |
The potential of gallic acid as a radiosensitizer on human prostate cancer: A systematic review of preclinical studies |
2021 |
Malaysian Journal of Medicine and Health Sciences |
17 |
2 |
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246 |
254 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104201486&partnerID=40&md5=aff7e4b57216dc4b88ee83f02823372e |
Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Cahyono, A.T., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mayang Permata, T.B., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Handoko, Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kodrat, H., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, H., Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hariandy Hamid, A.R.A., Department of Urology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sekarutami, S.M., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gondhowiardjo, S.A., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Prostate adenocarcinoma accounts for majority of prostate cancer cases, and it was found to be highly radioresistant. Gallic acid is a phenolic acid naturally occurring in many plants, reported to exhibit biological activities in eliminating cancer cell lines and xenografts. The purpose of this study is to review gallic acid as a potential radiosensitizer agent in prostate cancer treatment. Article search was conducted in PubMed, EBSCO, and Scopus. 11 studies using different cell lines including DU145, PC-3, LNCaP, and 22Rv1 xenograft of human prostate cancer were reviewed in this paper. Gallic acid acts as a radiosensitizer mainly by increasing caspase-3 and caspase-9 activation resulting in apoptosis, while also reducing intracellular CDKs, cyclins, and cdc25 phosphatases ultimately causing G2-M cell cycle arrest. Gallic acid has a potential to be a new radiosensitizer compound in prostate cancer treatment. Additional clinical studies using gallic acid derivatives with lower hydrophilicity are needed. © 2021 UPM Press. All rights reserved. |
Apoptosis; Gallic acid; Prostate cancer; Radiobiology; Radiotherapy |
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Universiti Putra Malaysia Press |
16758544 |
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Review |
Q4 |
144 |
23823 |
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465 |
Mochtar I., Adi N.P., Hardjono A.W., Mansyur M. |
57222902121;57023786200;57222902350;37085506800; |
Return to work assessment in a radiographer assistant suffering a hemianopsia due to an ischemic stroke |
2021 |
Malaysian Journal of Medicine and Health Sciences |
17 |
2 |
|
301 |
304 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104187321&partnerID=40&md5=cad74495ef91661c388194494f7d4e58 |
Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Occupational and Environmental Health Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Indonesian Occupational Medicine Specialist Association, Jakarta, 10350, Indonesia |
Mochtar, I., Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Adi, N.P., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia, Occupational and Environmental Health Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Hardjono, A.W., Indonesian Occupational Medicine Specialist Association, Jakarta, 10350, Indonesia; Mansyur, M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia, Occupational and Environmental Health Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia |
Return to work assessment (RTWA) has been performed to a radiographer assistant suffering a hemianopsia due to an ischemic stroke. Stroke occurred two months prior to the examination. The general condition of the patient was good. The systemic examination was unremarkable except the presence of a partial vision loss in the left eye and often feeling fatigue and down. Perimetry Full-field 120 Point Screening Test confirmed a left temporal hemianopsia while Patient Health Questionnaire’s score (PHQ-9) indicated a moderate depression. The two conditions were not fully compatible with the job demand of a radiographer assistant, which required a complete and clear visual field as well as a good mental status. Risk assessment indicated that the patient might encounter health and safety issues if he resumed duty without work adjustment. The clinic still wanted to employ the patient and agreed to provide support. The patient was declared ‘fit’ to resume his duty with some recommendations. © 2021 UPM Press. All rights reserved. |
Hemianopsia; Return to work; Stroke |
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Universiti Putra Malaysia Press |
16758544 |
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Article |
Q4 |
144 |
23823 |
|
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894 |
Sandhiutami N.M.D., Arozal W., Louisa M., Rahmat D. |
56692904000;32067462200;41461551400;36673726800; |
Determine Curcumin Concentration in Organ Rats and in Ovaries at Ovarian Cancer Model Rats Using Ultra Performance Liquid Chromatography-Mass Spectrometry (Ms)/Ms |
2021 |
Pharmaceutical Sciences Asia |
48 |
1 |
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37 |
45 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099915596&doi=10.29090%2fPSA.2021.02.19.146&partnerID=40&md5=59970a9906f368c7cd760cdd0765143e |
Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sandhiutami, N.M.D., Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Arozal, W., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmat, D., Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia |
Curcumin has several pharmacological effects including anti-inflammatory, reduce kidney damage, hepatoprotector, and inhibiting tumor growth in ovarian cancer. The use of curcumin is limited because it has low bioavailability and low capacity to reach target organs. This limitation is overcome by making it in the form of nanoparticles. This study aim to determine curcumin levels on some organ in healthy rat groups and on ovaries at ovarian cancer models rat that given curcumin and curcumin nanoparticles. Measurement of curcumin levels using UPLC-MS/MS. Determination of curcumin level in the organ was carried out in 2 treatment groups, group that received curcumin and group that received curcumin nanoparticles orally with a single dose of 100 mg/kg Body Weight (BW). At 180 minutes, rats were decapitated for liver, kidney and ovaries. The ovarian cancer rats were also divided into 2 groups and given curcumin and curcumin nanoparticles with repeated doses of 100 mg/kgBW/day and after 30 days, ovarian cancer rats were decapitated for the ovaries. In the group that received curcumin, the concentration of curcumin in the liver, kidney and ovaries were less than the detection limit, whereas in the group that received curcumin nanoparticles, the levels of curcumin are 1,866.6±22.60 ng/g in liver, 114.87±13.36 ng/g in kidney and 136.864±11.15 ng/g in ovaries. In ovarian cancer rats, levels of curcumin in the group receiving curcumin is 2.29±1.15 ng/g and 17.76±4.85 ng/g in the group receiving curcumin nanoparticles. Curcumin nanoparticles can increase the distribution of curcumin in liver, kidney, ovaries in healthy rats and in ovaries at ovarian cancer model rats. © 2020. All Rights Reserved. |
curcumin; curcumin nanoparticles; ovarian cancer rats; rats organ; UPLC MS/MS |
curcumin; nanoparticle; animal experiment; animal model; animal tissue; Article; cancer model; controlled study; drug determination; drug distribution; drug liver level; female; kidney homogenate; limit of detection; limit of quantitation; liquid chromatography-mass spectrometry; liver homogenate; measurement accuracy; measurement precision; nonhuman; ovary; ovary cancer; rat; repeated drug dose; single drug dose |
Mahidol University - Faculty of Pharmacy |
25868195 |
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Article |
Q3 |
144 |
23834 |
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