No records
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834 |
Ibrahim F., Natasha A., Saharman Y.R., Yasmon A., Fithriyah F., Karuniawati A., Ganiesa S., Sudarmono P. |
54886001500;57211428938;55980934300;41462004500;57210142453;54886816200;57222740114;6507855437; |
Consideration of the Cycle Threshold Values from Real-Time RT-PCR SARS-CoV-2 Interpretation for the Clinicians: Analysis of 339 Positive Cases from a Referral Laboratory in Jakarta, Indonesia |
2021 |
Acta medica Indonesiana |
53 |
1 |
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13 |
17 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103921764&partnerID=40&md5=34f56312ba1b549b121d030e28212342 |
Clinical Microbiology Department, faculty of medicine, University of Indonesia |
Ibrahim, F., Clinical Microbiology Department, faculty of medicine, University of Indonesia; Natasha, A.; Saharman, Y.R.; Yasmon, A.; Fithriyah, F.; Karuniawati, A.; Ganiesa, S.; Sudarmono, P. |
BACKGROUND: real-time RT-PCR was recommended by WHO for COVID-19 diagnosis. The cycle threshold (Ct) values were expected to have an association with clinical manifestation. However, the diagnostic modalities such as quantitative molecular detection and virus isolation were not yet available for the routine test. This study has been conducted to analyze the relationship between the Ct values of qualitative rRT-PCR and the clinical manifestation and to describe the factors determining the result. METHODS: from March to April 2020, specimens were sent to our laboratory from different healthcare centers in Jakarta. The patient's characteristic and clinical manifestation were extracted from the specimen's epidemiology forms. The specimens extracted and tested using rRT-PCR, and the Ct value were collected. The data were analyzed using the appropriate statistic test. RESULTS: from 339 positive results, the mild to moderate case was 176 (52%) and the severe cases was 163 (48%). Female was dominant in the mild to moderate cases (58%), while the male was prevalent in the severe cases (60%). The median age for mild to moderate case was 35 years old and severe cases was 49 years old. Statistical analysis found relationship between both group with gender (p = 0.001) and age (p < 0.001), but not with the Ct value. CONCLUSION: many variables in specimen sampling and processing could affect the Ct value result. In addition, the disease's severity was depended with the host immune response, regardless the number of virus. There was suggested no significant difference between the Ct values of mild-moderate and severe COVID-19, and thus should not be loosely interpreted. |
clinical interpretation; Cycle Threshold; rRT-PCR; SARS-Cov-2 |
adult; age; diagnosis; epidemiology; female; human; Indonesia; isolation and purification; male; middle aged; observer variation; pathophysiology; physiology; procedures; real time polymerase chain reaction; reproducibility; severity of illness index; sex factor; symptom assessment; virus load; Adult; Age Factors; Correlation of Data; COVID-19; COVID-19 Nucleic Acid Testing; Female; Humans; Indonesia; Male; Middle Aged; Observer Variation; Real-Time Polymerase Chain Reaction; Reproducibility of Results; SARS-CoV-2; Severity of Illness Index; Sex Factors; Symptom Assessment; Viral Load |
NLM (Medline) |
01259326 |
|
33818402 |
Article |
Q3 |
321 |
14162 |
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835 |
Loho T., Widodo D. |
55624513300;8231822900; |
Rapid Antigen Detection Test for Severe Acute Respiratory Syndrome Coronavirus 2: How to Use It Properly? |
2021 |
Acta medica Indonesiana |
53 |
1 |
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119 |
131 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103921511&partnerID=40&md5=d85899546f23d6d70bd458483c6c9ac1 |
Department of Clinical Pathology, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Loho, T., Department of Clinical Pathology, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Widodo, D. |
Cases of coronavirus disease 2019 (COVID-19) in Indonesia are still increasing and even higher in the last few weeks. Contact tracing and surveillance are important to locate cases in the community, including asymptomatic individuals. Diagnosis of COVID-19 depends on the detection of viral RNA, viral antigen, or indirectly, viral antibodies. Molecular diagnosis, using real time, reverse transcriptase polymerase chain reaction (RT-PCR), is the common standard method; however, it is not widely available in Indonesia and requires a high standard laboratory. Rapid, point-of-care antibody testing has been widely used as an alternative; however, interpretation of the results is not simple and now it is no longer used by the Indonesian government as a screening test for people travelling between locations. Thus, the rapid antigen detection test (Ag-RDT) is used by the Indonesian government as a screening test for travellers. As a result, many people buy the kit online and perform self-Ag-RDT at home. This raises the question of how safe and accurate it is to perform self-Ag-RDT at home. Before a test is applied, it is suggested to research its sensitivity and specificity, as compared to gold standard, and its limitations. In this article, laboratory diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is discussed, with an emphasis on Ag-RDT and the recommendation to use it properly in daily practice. |
antigen testing; COVID-19; SARS-CoV-2 |
virus antibody; virus RNA; diagnosis; epidemiology; human; immunology; isolation and purification; physiology; prevention and control; procedures; reproducibility; sensitivity and specificity; Antibodies, Viral; COVID-19; COVID-19 Nucleic Acid Testing; COVID-19 Serological Testing; Humans; Reproducibility of Results; RNA, Viral; SARS-CoV-2; Sensitivity and Specificity |
NLM (Medline) |
01259326 |
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33818415 |
Article |
Q3 |
321 |
14162 |
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836 |
Nelwan E.J., Tunjungputri R.N., Tunjung N., Widodo D. |
14527452900;56342194400;57208446370;8231822900; |
Hospital-acquired Skin and Skin-structure Infection in COVID-19 Infected Patient with Prolonged Hospitalization |
2021 |
Acta medica Indonesiana |
53 |
1 |
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105 |
107 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103921503&partnerID=40&md5=23cf0f1fefa15f3ad7ca5a2fea78cdeb |
Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Nelwan, E.J., Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Tunjungputri, R.N.; Tunjung, N.; Widodo, D. |
Acute bacterial skin and skin-structure infections (ABSSSI) is defined in 2013 by the US Food and Drug Administration as a bacterial cellulitis/erysipelas, major skin abscesses, and wound infections. The Infectious Diseases Society of America (IDSA) in 2014 classifies skin and soft-tissue infection (SSTI) as either non-purulent (which includes cellulitis, erysipelas, and necrotizing infection) or purulent (including furuncle, carbuncle, and abscess). Among hospitalized patients with SSTI, healthcare-associated infections account for 73.5% of all cases. Notably, skin and skin-structure infections caused by Pseudomonas aeruginosa, a common hospital pathogen, was reported to cause higher total cost and longer hospital length of stay compared to non-P. aeruginosa cases, despite causing only approximately 5.7% of all healthcare-associated SSTIs. Infection with P. aeruginosa should always be considered in non-healing skin infections in patients with prolonged hospitalization and antibiotic exposure. Tissue culture, preferably taken by surgical debridement, should be promptly performed; and when hospital-infection is suspected, appropriate antibiotics should be started along with removal of all devitalized tissue and to promote skin and soft tissue healing. Expedited discharge should be considered when possible, with adequate antibiotic treatment and follow up for definitive wound treatment. |
COVID-19; Hospital-acquired skin; prolonged hospitalization; skin-structure infection |
antiinfective agent; linezolid; case report; complication; debridement; female; hospitalization; human; iatrogenic disease; isolation and purification; microbiology; middle aged; pathology; pathophysiology; procedures; skin; skin infection; treatment outcome; Anti-Bacterial Agents; COVID-19; Debridement; Female; Hospitalization; Humans; Iatrogenic Disease; Linezolid; Middle Aged; SARS-CoV-2; Skin; Skin Diseases, Infectious; Treatment Outcome |
NLM (Medline) |
01259326 |
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33818413 |
Article |
Q3 |
321 |
14162 |
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837 |
Setiati S., Marsigit J. |
14325991900;57218912589; |
COVID-19 Vaccine for Elderly: Should We Be Reactive or Proactive? |
2021 |
Acta medica Indonesiana |
53 |
1 |
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1 |
4 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103921302&partnerID=40&md5=6cdc928dd1802691cbcb0d3e3aa26a36 |
1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Indonesia. 2. Clinical Epidemiology and Evidence-Based Medicine, Cipto Mangunkusumo HospitalJakarta, Indonesia |
Setiati, S., 1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Indonesia. 2. Clinical Epidemiology and Evidence-Based Medicine, Cipto Mangunkusumo HospitalJakarta, Indonesia; Marsigit, J. |
It has been a year since the Indonesian government announced its first COVID-19 identified in Jakarta. Since then, there have been more than 900,000 cases in Indonesia with case fatality rate (CFR) of 2.9%. The number of new cases per day is now ranging from 9,000 cases to almost 13,000 cases. Not only in Indonesia, but the number of new cases along with the mortality rate in other countries, such as Malaysia, Japan, United States, and Europe region also increased dramatically. COVID-19 vaccines are being investigated and the world hopes that vaccines will be the answer to tackle this pandemic. Is it really so? Immunization is an effort to induce immunity in individuals to prevent a disease or the complication related to the diseases that may be catastrophic. Immunization can be divided into passive, which is by giving certain type of antibody and active, which means that either we get the disease, or we get the antigen injected into our body.Having prior vaccination or past COVID-19 does not mean that someone is totally immune to COVID-19 as a recent study suggested that the antibody related to COVID-19 past infection is significantly decreasing after 3 months post-infection. Compliance to implementation of health protocol remained the most crucial strategy during this pandemic. |
COVID-19; COVID-19 vaccine; elderly; vaccine |
administration and dosage; adverse event; aged; female; frail elderly; frailty; geriatric assessment; human; Indonesia; male; organization and management; prevention and control; procedures; risk assessment; risk factor; seroconversion; vaccination; Aged; COVID-19; COVID-19 Vaccines; Female; Frail Elderly; Frailty; Geriatric Assessment; Humans; Indonesia; Male; Risk Adjustment; Risk Factors; SARS-CoV-2; Seroconversion; Vaccination |
NLM (Medline) |
01259326 |
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33818400 |
Article |
Q3 |
321 |
14162 |
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838 |
Ginanjar E., Alwi I., Lydia A., Immanuel S., Yamin M., Indrajaya T., Harimurti K. |
23472616600;15055173800;8451287200;12777341300;23475706300;54994136500;23473513200; |
The Association of β2-Microglobulin and Fibroblast Growth Factor 23 with Major Adverse Cardiac Event in Acute Coronary Syndrome Patients with Chronic Kidney Disease |
2021 |
Acta medica Indonesiana |
53 |
1 |
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5 |
12 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103921128&partnerID=40&md5=095d67ad322b9a2d7ea79b6dde38e4cd |
Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Ginanjar, E., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Alwi, I.; Lydia, A.; Immanuel, S.; Yamin, M.; Indrajaya, T.; Harimurti, K. |
BACKGROUND: chronic kidney disease (CKD) increases the severity and risk of mortality in acute coronary syndrome (ACS) patients. The role of β2-M as a filtration and inflammation marker and FGF23 as a CKD-MBD process marker might be significant in the pathophysiology in ACS with CKD patients. This study aims to determine the association of β2-M and FGF23 with major adverse cardiac event (MACE) in ACS patients with CKD. METHODS: we used cross sectional and retrospective cohort analysis for MACE. We collected ACS patients with CKD consecutively from January until October 2018 at Dr. Cipto Mangunkusumo General Hospital. Data were analyzed using logistic regression and Cox's Proportional Hazard Regression. RESULTS: a total of 117 patients were selected according to the study criteria. In bivariate analysis, β2-M, FGF23, and stage of CKD had significant association with MACE (p = 0.014, p = 0.026, p = 0.014, respectively). In multivariate analysis, β2-M - but not FGF 23- was significantly associated with MACE (adjusted HR 2.16; CI95% 1.15-4.05; p = 0.017). CONCLUSION: β2-M was significantly associated with MACE, while FGF23 was not so. This finding supports the role of inflammation in cardiovascular outcomes in ACS with CKD patient through acute on chronic effect. |
Acute Coronary Syndrome; Beta2-Microglobulin; Fibrioblast Growth Factor 23; Major Adverse Cardiac Event |
beta 2 microglobulin; biological marker; fibroblast growth factor; fibroblast growth factor 23; acute coronary syndrome; aged; blood; chronic kidney failure; complication; cross-sectional study; female; human; Indonesia; male; middle aged; mortality; multivariate analysis; predictive value; prognosis; retrospective study; risk factor; survival analysis; Acute Coronary Syndrome; Aged; beta 2-Microglobulin; Biomarkers; Cross-Sectional Studies; Female; Fibroblast Growth Factors; Humans; Indonesia; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Prognosis; Renal Insufficiency, Chronic; Retrospective Studies; Risk Factors; Survival Analysis |
NLM (Medline) |
01259326 |
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33818401 |
Article |
Q3 |
321 |
14162 |
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839 |
Ayuandari S., Khasanah N., Riyanti I., Dewanto A., Enisar Sangun D., Wiweko B. |
56231262400;57222708996;57222710738;57190580042;57222709491;43061741400; |
Current awareness and attitude toward fertility preservation in Indonesia: A nationwide survey among health-care providers |
2021 |
Journal of Human Reproductive Sciences |
14 |
1 |
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81 |
86 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103760305&doi=10.4103%2fjhrs.jhrs_239_20&partnerID=40&md5=10c9f18d628ded6d4e5658e52f96eb59 |
Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yasmin Ivf Clinic, Dr. Cipto Mangunkusumo General Hospital, Hum. Repro., Infertility and Fam. Plan. Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Indonesia Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia |
Ayuandari, S., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Khasanah, N., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Riyanti, I., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Dewanto, A., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Enisar Sangun, D., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Wiweko, B., Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Yasmin Ivf Clinic, Dr. Cipto Mangunkusumo General Hospital, Hum. Repro., Infertility and Fam. Plan. Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Indonesia Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia |
Context: Fertility preservation (FP) is necessary for cancer patients who develop infertility due to chemotherapy and radiotherapy. In Indonesia, many systematic steps and long-Term continued actions must be taken to establish FP units since there has been an increasing incidence of cancer among people under 45 years old. Aims: This study aimed at a comprehensive evaluation on the awareness and practices of health-care providers (HCPs) toward FP. Settings and Design: This was a descriptive cross-sectional study. Subjects and Methods: A validated nationwide online survey was completed by 160 HCPs as a representative sample from 11 provinces in 2017 that provide medical care to cancer patients at hospitals or clinics. Statistical Analysis Used: Descriptive statistics, analysis of variance, logistic regression, and Pearson correlation tests were used for the statistical analysis. Results: Respondents were specialists (59.4%) and other HCPs (40.6%). Around 60% of the HCPs who performed cancer therapies already discussed the fertility issues with their patients. Meanwhile, the HCPs (60.7%) also tended not to consult and refer their patients to fertility experts (P < 0.05). However, those who discussed the risk of infertility with patients tended to consult with and refer them to a fertility consultant for further FP procedure as the follow-up for their discussions (odds ratio = 8.98, confidence interval 95%, P < 0.05). Conclusions: In Indonesia, FP awareness of the HCPs who performed cancer therapy was high. Nevertheless, attitudes to refer patients to fertility experts for possible FP management still need to be improved. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Attitude; awareness; fertility preservation; health-care providers |
adult; analysis of variance; article; awareness; cancer patient; cancer therapy; controlled study; cross-sectional study; female; fertility preservation; fertility specialist; follow up; health survey; human; human tissue; Indonesia; male; medical care; risk assessment |
Wolters Kluwer Medknow Publications |
09741208 |
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Article |
Q3 |
484 |
10359 |
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841 |
Wijaya D.A., Louisa M., Wibowo H., Taslim A., Permata T.B.M., Handoko, Nuryadi E., Kodrat H., Gondhowiardjo S.A. |
57222657856;41461551400;57217690943;57222661883;57197808751;57209984822;57197806814;57210639849;6508327402; |
The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agents: Proposed mechanisms based on a systematic review |
2021 |
Journal of HerbMed Pharmacology |
10 |
2 |
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166 |
178 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103633859&doi=10.34172%2fjhp.2021.18&partnerID=40&md5=810428f36d6d7326990b348f1d1a958a |
Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Laboratorium Terpadu, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia |
Wijaya, D.A., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Wibowo, H., Laboratorium Terpadu, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Taslim, A., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Permata, T.B.M., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Handoko, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Kodrat, H., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Gondhowiardjo, S.A., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia |
Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds such as annonaceous acetogenins, annomuricin, annonacin, or curcumin; and further correlated them with the potential of the mechanism to increase or to reduce cancer cells radio-sensitivity based on literature investigation. We see that AM has a promising future potential as a radio-sensitizer agent. © 2021 Nickan Research Institute. All rights reserved. |
Annona muricata; Bioactive compounds; Plant extract; Radio-sensitivity; Radiotherapy |
acetogenin; Annona muricata extract; annonacin; apoptosome; caspase 9; curcumin; cyclin D1; cyclin D2; death domain receptor signaling adaptor protein; Fas ligand; glucose transporter 4; glycogen synthase kinase; hypoxia inducible factor 1alpha; immunoglobulin light chain; interleukin 13; lactate dehydrogenase; mammalian target of rapamycin; mitogen activated protein kinase; mitogen activated protein kinase 1; mitogen activated protein kinase 3; phosphatidylserine; procaspase 3; protein Bax; protein bcl 2; protein mcl 1; protein p105; protein p50; protein p53; radiosensitizing agent; reactive oxygen metabolite; STAT3 protein; stress activated protein kinase; transcription factor RelA; transcription factor RelB; tumor necrosis factor; Annona muricata; apoptosis; B cell lymphoma; cell aging; |
Nickan Research Institute |
23455004 |
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Review |
Q3 |
341 |
13610 |
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846 |
Sitohang I.B.S. |
56734569200; |
Isotretinoin for treating acne vulgaris |
2021 |
International Journal of Applied Pharmaceutics |
13 |
2 |
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20 |
25 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103244010&doi=10.22159%2fijap.2021v13i2.40045&partnerID=40&md5=d324facccc1fd7db650538b96ff62380 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Acne vulgaris (AV) occurs in more than 80% of dermatological cases in adolescents and young adults and affects the quality of life. Oral isotretinoin, a metabolite product of vitamin A, is well-known to be the most effective treatment for severe nodulocystic AV and moderate AV that does not respond to other therapeutic modalities. Thus, this literature review was conducted to explain the mechanism of action, effectiveness, contraindications, side effects, and safety of oral isotretinoin in AV, which provided essential information for dermatologists. Furthermore, isotretinoin is the only treatment modality that has implications for the entire pathogenesis of acne. It contributes to decreasing corneocytes’ adhesion, supporting cellular proliferation and follicular renewal, induction of cell apoptosis, and immune regulation. The effectiveness of AV therapy with isotretinoin has expanded as it is also indicated for moderate to severe AV that does not respond well to topical combination therapy or systemic antibiotics. However, isotretinoin is included in Category X drugs and may induce many side effects from mucocutaneous effects to teratogenicity. From this extensive literature review, it can be concluded that isotretinoin is one of the treatment modalities for acne with good effectivity due to its mechanism of actions that affect the entire acne pathogenesis. Considering the various side effects of isotretinoin, its use requires adequate clinical assessment and monitoring by a dermatologist. © 2021 The Authors. |
Acne vulgaris; Contraindications; Effectiveness; Isotretinoin; Safety; Side effects |
antibiotic agent; isotretinoin; retinoic acid; acne vulgaris; algorithm; apoptosis; cell proliferation; cheilitis; clinical assessment; dermatologist; eczema; epistaxis; eye disease; fatigue; half life time; headache; human; immunoregulation; infection; minimum concentration; pathogenesis; pharmacokinetic parameters; prevalence; Review; skin fragility; teratogenicity |
Innovare Academics Sciences Pvt. Ltd |
09757058 |
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Review |
Q3 |
238 |
17272 |
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847 |
Atmosudigdo I.S., Lim M.A., Radi B., Henrina J., Yonas E., Vania R., Pranata R. |
57222578186;57216039756;6603494019;57218482646;57201987097;57208328436;57201973901; |
Dyslipidemia Increases the Risk of Severe COVID-19: A Systematic Review, Meta-analysis, and Meta-regression |
2021 |
Clinical Medicine Insights: Endocrinology and Diabetes |
14 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103239096&doi=10.1177%2f1179551421990675&partnerID=40&md5=f2529886c6cb74cf353635e1abd100c3 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Balaraja General Hospital, Tangerang, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Division of Plastic, Reconstructive and Aesthetic, Department of Surgery, Faculty of Medicine, Sanglah General Hospital, Udayana University, Bali, Indonesia |
Atmosudigdo, I.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Radi, B., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Henrina, J., Balaraja General Hospital, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Division of Plastic, Reconstructive and Aesthetic, Department of Surgery, Faculty of Medicine, Sanglah General Hospital, Udayana University, Bali, Indonesia; Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia |
Objective: This systematic review and meta-analysis aimed to evaluate whether dyslipidemia affects the mortality and severity of COVID-19, we also aimed to evaluate whether other comorbidities influence the association. Methods: A systematic literature search using PubMed, Embase, and EuropePMC was performed on 8 October 2020. This study’s main outcome is a poor composite outcome, comprising of mortality and severe COVID-19. Results: There were 9 studies with 3663 patients. The prevalence of dyslipidemia in this pooled analysis was 18% (4%-32%). Dyslipidemia was associated with increased composite poor outcome (RR 1.39 [1.02, 1.88], P =.010; I2: 56.7%, P =.018). Subgroup analysis showed that dyslipidemia was associated with severe COVID-19 (RR 1.39 [1.03, 1.87], P =.008; I2: 57.4%, P =.029). Meta-regression showed that the association between dyslipidemia and poor outcome varies by age (coefficient: −0.04, P =.033), male gender (coefficient: −0.03, P =.042), and hypertension (coefficient: −0.02, P =.033), but not diabetes (coefficient: −0.24, P =.135) and cardiovascular diseases (coefficient: −0.01, P =.506). Inverted funnel-plot was relatively symmetrical. Egger’s test indicates that the pooled analysis was not statistically significant for small-study effects (P =.206). Conclusion: Dyslipidemia potentially increases mortality and severity of COVID-19. The association was stronger in patients with older age, male, and hypertension. PROSPERO Registration Number: CRD42020213491 © The Author(s) 2021. |
coronavirus; COVID-19; dyslipidemia; hyperlipidemia; prognosis |
Article; comorbidity; coronavirus disease 2019; diabetes mellitus; disease association; disease severity; dyslipidemia; human; hypertension; infection risk; mortality; prevalence; prognosis; risk assessment; systematic review |
SAGE Publications Ltd |
11795514 |
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Article |
Q3 |
527 |
9598 |
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849 |
Pontoh L.A.P., Rahyussalim A.J., Widodo W., Fiolin J., Rhatomy S. |
57192907426;55212166100;57208941551;57194498274;57204509883; |
Anthropometric study as a predictor of anterior cruciate ligament sizes in Asian Indonesian population |
2021 |
Journal of Orthopaedic Surgery |
29 |
1 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102931782&doi=10.1177%2f23094990211000462&partnerID=40&md5=115eb91e8582294904d6485d349881e8 |
Department of Orthopaedics and Traumatology, Fatmawati General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Pondok Indah General Hospital, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Dr Soeradji Tirtonegoro General Hospital, Klaten, Indonesia; Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia |
Pontoh, L.A.P., Department of Orthopaedics and Traumatology, Fatmawati General Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahyussalim, A.J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Orthopaedics and Traumatology, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Widodo, W., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Orthopaedics and Traumatology, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Fiolin, J., Department of Orthopaedics and Traumatology, Pondok Indah General Hospital, Jakarta, Indonesia; Rhatomy, S., Department of Orthopaedics and Traumatology, Dr Soeradji Tirtonegoro General Hospital, Klaten, Indonesia, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia |
Objectives: To evaluate whether anthropometric data can predict anterior cruciate ligament (ACL) sizes on magneti resonance imaging (MRI) in Asian population. Background: Reconstruction of ACL has been performed over a decade ago. Recently, more individualized ACL reconstruction is performed taking account of each patient’s ACL characteristics. However, there has been limited study regarding ACL sizes in Asian Indonesian population. This study aimed to evaluate the role of anthropometric data in ACL sizes using MRI in Asian Indonesian population. Study Design: Retrospective Study. Method: A series of 531 knees from 420 patients with knee pain and intact ACL confirmed by MRI study. Length, width and inclination angle of ACL were measured using a T2-weighted sagittal MRI 3.0 Tesla Magnetom Skyra. Height, weight, body mass index (BMI) and age were recorded. Multiple regression analysis was used to determine relationship between the anthropometric data and size of ACL measurements. Result: ACL length and width were significantly different between male and female, consecutively. Mean ACL length was 35.36 ± 3.63 mm, male was significantly longer (36.59 ± 3.24 mm) compared to female (32.77 ± 2.99 mm), p < 0.0001. Mean ACL width was 10.23 ± 1.84 mm, male was significantly wider (10.85 ± 1.59 mm) compared to female (8.93 ± 1.64 mm), p < 0.0001. The mean ACL inclination angle was 47.75° ± 3.07° (range 40.17°–57.12°). The strongest correlation for ACL length was height and weight (r = 0.437; r = 0.341 consecutively, p < 0.0001). Females had stronger correlation compared to males for ACL length (R2 = 0.489 vs R2 = 0.418). ACL width showed weak correlation with anthropometric data. The following regression analysis equation was obtained for ACL length: ACL length = 60.697 − 0.11*age + 0.461*weight (kg) − 16.522*height (meter) − 1.093*BMI (R2 = 0.539; p < 0.0001). Conclusion: Anthropometric data can be utilized as a predictor of ACL length in Asian Indonesian population. The ACL length in Asian Indonesian population is shorter than that in Western population study. © The Author(s) 2021. |
ACL sizes; anthropometric data; Asian population; magnetic resonance imaging |
adult; anterior cruciate ligament; anthropometry; Article; body height; body mass; body weight; clinical evaluation; female; human; Indonesian; knee pain; major clinical study; male; nuclear magnetic resonance imaging; population research; prediction; retrospective study; sex difference; adolescent; anatomy and histology; anterior cruciate ligament; Asian continental ancestry group; diagnostic imaging; epidemiology; Indonesia; knee; morphometry; organ size; pathology; procedures; young adult; Adolescent; Adult; Anterior Cruciate Ligament; Asian Continental Ancestry Group; Body Mass Index; Body Weights and Measures; Female; Humans; Indonesia; Knee; Knee Joint; Magnetic Resonance Imaging; Male; Organ Size; Retrospective Studies; Young Adult |
SAGE Publications Ltd |
10225536 |
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33745362 |
Article |
Q3 |
457 |
10873 |
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