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26 |
Soemantri D., Greviana N., Findyartini A., Azzahra T.B., Suryoadji K.A., Mustika R., Felaza E. |
36640659100;57197709749;56543777300;57223601523;57223633894;57220273147;57217487889; |
"To obey or not to obey" - Medical students' response towards professional dilemmas in a hierarchical and collectivist culture |
2021 |
PLoS ONE |
16 |
12 December |
e0261828 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122028276&doi=10.1371%2fjournal.pone.0261828&partnerID=40&md5=379871263550acde1f1182540ba60243 |
Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Undergraduate Medical Program, Universitas Indonesia, Jakarta, Indonesia |
Soemantri, D., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Greviana, N., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Findyartini, A., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Azzahra, T.B., Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Undergraduate Medical Program, Universitas Indonesia, Jakarta, Indonesia; Suryoadji, K.A., Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Undergraduate Medical Program, Universitas Indonesia, Jakarta, Indonesia; Mustika, R., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Felaza, E., Faculty of Medicine, Department of Medical Education, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia |
Background Clinical clerkship programme in medical schools were developed to provide students with direct interactions with patients and observe clinical teachers in practice. However, professional dilemmas are prone to occur due to the nature of experiential learning. Several studies across different cultures showed that medical students responded differently towards professional dilemma. Aims This study aims to explore how medical students respond to professional dilemmas occurred during their clinical clerkships and to what extent culture influences the responses. Method A qualitative descriptive approach was used in this study. We conducted four focus group discussions with final year medical students who were selected using maximum variety sampling method. Thematic analysis was conducted following the transcription of the focus groups. Results We identified the impact of dilemmas on students' emotions and concerns, students' responses towards professional dilemmas, and factors affecting responses to dilemmas in clinical clerkship, which confirmed that cultures played roles in how students responded towards professional dilemmas. Conclusion This study has identified that culture, to some extent, influenced the way students responded to professional dilemmas. Therefore, it is paramount to develop a conducive and culturally sensitive educational environment and students' ability to learn from professional dilemma experienced in the workplace for developing their professional identity. © 2021 Soemantri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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article; clinical education; emotion; genetic transcription; human; human experiment; medical student; thematic analysis; workplace; clinical trial; emotion; female; male; medical school; problem based learning; Emotions; Female; Humans; Male; Problem-Based Learning; Schools, Medical; Students, Medical |
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19326203 |
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Koesnoe S., Masjkuri N., Adisasmita A., Djauzi S., Kartasasmita C., Sundoro J., Nadjib M., Korib M., Muthia A.N., Muzellina V.N., Habibah U., Nursyirwan S.A., Djaya K.H., Bachtiar N.S., Sari R.M. |
26028015000;57189271669;22978283200;23495847800;57206248946;49762130000;24401623600;57391576000;57391576100;57223968527;57391443900;57249143800;57392218600;54879388400;57191341371; |
A randomized controlled trial to evaluate the effect of influenza vaccination and probiotic supplementation on immune response and incidence of influenza-like illness in an elderly population in Indonesia |
2021 |
PLoS ONE |
16 |
12 December |
e0250234 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122024701&doi=10.1371%2fjournal.pone.0250234&partnerID=40&md5=6918933f17507c8ed64013b241adb3c2 |
Division of Allergy and Immunology, Department of Internal Medicine, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Indonesia; Indonesian Technical Advisory Group on Immunization, Jakarta, Indonesia; Department of Health Policy and Administration, Faculty of Public Health University of Indonesia, Jakarta, Indonesia; Indonesian Society of Internal Medicine, Jakarta, Indonesia; Division of Gastroenterology, Depertment of Internal Medicine, dr. Cipto Mangunkusomo Hospital, Jakarta, Indonesia; Division of Gastroenterology, Depertment of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; PT. Bio Farma, Bandung, Indonesia |
Koesnoe, S., Division of Allergy and Immunology, Department of Internal Medicine, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Masjkuri, N., Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Adisasmita, A., Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Djauzi, S., Division of Allergy and Immunology, Department of Internal Medicine, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Kartasasmita, C., Department of Child Health, Faculty of Medicine, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Indonesia; Sundoro, J., Indonesian Technical Advisory Group on Immunization, Jakarta, Indonesia; Nadjib, M., Department of Health Policy and Administration, Faculty of Public Health University of Indonesia, Jakarta, Indonesia; Korib, M., Department of Epidemiology, Faculty of Public Health University of Indonesia Jakarta, Jakarta, Indonesia; Muthia, A.N., Indonesian Society of Internal Medicine, Jakarta, Indonesia; Muzellina, V.N., Division of Gastroenterology, Depertment of Internal Medicine, dr. Cipto Mangunkusomo Hospital, Jakarta, Indonesia, Division of Gastroenterology, Depertment of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Habibah, U., Indonesian Society of Internal Medicine, Jakarta, Indonesia; Nursyirwan, S.A., Division of Gastroenterology, Depertment of Internal Medicine, dr. Cipto Mangunkusomo Hospital, Jakarta, Indonesia, Division of Gastroenterology, Depertment of Internal Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Djaya, K.H., Indonesian Society of Internal Medicine, Jakarta, Indonesia; Bachtiar, N.S., PT. Bio Farma, Bandung, Indonesia; Sari, R.M., PT. Bio Farma, Bandung, Indonesia |
Aim To investigate the effect of influenza vaccination with or without probiotic supplementation on the immune response and incidence of influenza-like illness (ILI) in the elderly. Methods A randomized double-blind, placebo-controlled trial with a modified factorial design was conducted in 554 healthy elderly subjects aged 67 ± 5.6 (ranging from 60–90) years old in the Primary Health Care Center (Puskesmas area) of the Pulo Gadung District East Jakarta. Subjects received either a trivalent influenza vaccine or placebo at the start of the study, and a probiotic supplement (Lactobacillus helveticus R0052 and Lactobacillus rhamnosus R0011) or a placebo for 6 months. Subjects were randomly assigned into four intervention groups: influenza vaccine and probiotics (n = 141), influenza vaccine and placebo (n = 136), placebo and probiotics (n = 140), and both placebo (n = 137). The primary outcome was ILI incidence within 6 months. The secondary outcomes were seroprotection and seroconversion rates at 1, 4, and 6 months after administering the interventions. Results This study showed that the trivalent influenza vaccine increased seroprotection (RR 3.6 [95%CI 2.92–4.47]; p<0.010) and seroconversion (RR 29.8 [95%CI 11.1–79.5]; p<0.010) rates 1 month after vaccination in elderly people while the probiotic supplement did not alter influenza antibody titers (p = 1.000 and p = 0.210). The relative ILI incidence risk was similar between vaccinated and non-vaccinated groups, as well as in the probiotic group compared to the non-probiotic group. Conclusion The tested trivalent influenza vaccine significantly induced seroprotection and seroconversion in the vaccinated subjects, while probiotics administration did not influence these parameters. Vaccinated individuals displayed a similarly low ILI incidence as those in the Control Group. However, the observed trend towards a reduction of ILI incidence with probiotics supplementation warrants further assessments in a larger, at-risk population. © 2021 Koesnoe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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flubio; influenza vaccine; placebo; influenza vaccine; probiotic agent; adult; aged; antibody titer; Article; controlled study; diet supplementation; double blind procedure; drug effect; female; human; immune response; incidence; Indonesia; influenza; major clinical study; male; middle aged; population risk; population structure; primary health care; randomized controlled trial; sample size; seroconversion; treatment duration; treatment outcome; vaccination; very elderly; incidence; influenza; Lactobacillus helveticus; Lactobacillus rhamnosus; Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Incidence; Indonesia; Influenza Vaccines; Influenza, Human; Lactobacillus helveticus; Lactobacillus rhamnosus; Male; Middle Aged; Probiotics |
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Tamin S., Adham M., Noer A., Supriana N., Bardosono S. |
57195719598;14024202100;57370851100;8438653200;21933841000; |
Upright epiglottis prevents aspiration in patients with nasopharyngeal carcinoma post-chemoradiation |
2021 |
PLoS ONE |
16 |
12 December |
e0261110 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121054797&doi=10.1371%2fjournal.pone.0261110&partnerID=40&md5=c09f68482b8e097a20b06089e0d5849e |
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radio Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Nutrition Science, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Tamin, S., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Adham, M., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Noer, A., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Supriana, N., Department of Radio Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bardosono, S., Department of Nutrition Science, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
NPC is the most widely found malignant tumor in the head and neck region in Indonesia. Chemoradiation therapy for NPC can induce swallowing disorders (dysphagia) that adversely affects a patients quality of life. This study aimed to assess the swallowing process by flexible endoscopic evaluation of swallowing in patients with nasopharyngeal carcinoma after chemoradiation. Thirty-nine patients with NPC who had chemoradiation therapy more than one month previously underwent flexible endoscopic evaluation of swallowing and were assessed for oral transport time, sensation, standing-secretion, pre-swallowing leakage, residue, penetration, aspiration, and silent aspiration. The most common structural abnormalities were an upright and swollen epiglottis (89.4%), poor oral hygiene, and velopharyngeal closure defects (56.4%). This examination also revealed a mild degree of standing secretion (38.5%) and aspiration (10.3%). No penetration was observed in 64.1% of the patients, and no silent aspiration was observed in any of the patients. A severe degree of residue (45.7%) was observed when administering oatmeal, while the residue was mild to moderate when administering gastric rice, crackers, and milk. The residue changed to a mild degree (32.3%-51.4%) in all food administrations after the watering maneuver. The highest penetration was noted after oatmeal administration (42.8%), and the highest aspiration was found after milk administration (8.6%). Standing secretion in almost all patients was caused by hyposensitivity of the hypopharynx. Persistent residue and hyposensitivity of the hypopharynx led to aspiration. The low percentage of aspiration and silent aspiration might have been caused by the upright and swollen epiglottis that prevented aspiration. Poor oral hygiene and a dry mouth led to prolonged oral transport. Therefore, most patients had hypopharyngeal abnormalities in the form of a swollen and upright epiglottis. Secretion and food residue were also detected. Drinking helps to expedite the swallowing process by facilitating oral phase transport and reducing residues. © 2021 Tamin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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acid aspiration; adult; adverse event; chemoradiotherapy; digestive tract endoscopy; dysphagia; female; human; male; middle aged; nasopharynx carcinoma; nasopharynx tumor; pathology; pathophysiology; procedures; Adult; Chemoradiotherapy; Deglutition Disorders; Endoscopy, Digestive System; Female; Humans; Male; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Respiratory Aspiration |
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Paramita R.I., Nelwan E.J., Fadilah F., Renesteen E., Puspandari N., Erlina L. |
54882436900;14527452900;56966708600;57216633036;56786591900;57190181680; |
Genome-based characterization of Escherichia coli causing bloodstream infection through next-generation sequencing |
2021 |
PLoS ONE |
15 |
12 December |
e0244358 |
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5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099074536&doi=10.1371%2fjournal.pone.0244358&partnerID=40&md5=4997d32055c7a3e5834f747ae4be685e |
Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Bioinformatics Core Facilities-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Infectious Disease and Immunology Research Center-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, DKI Jakarta, Indonesia |
Paramita, R.I., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Bioinformatics Core Facilities-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Nelwan, E.J., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Infectious Disease and Immunology Research Center-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Fadilah, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Bioinformatics Core Facilities-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Renesteen, E., Infectious Disease and Immunology Research Center-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia; Puspandari, N., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, DKI Jakarta, Indonesia; Erlina, L., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Bioinformatics Core Facilities-IMERI, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, DKI Jakarta, Indonesia |
Escherichia coli are one of the commonest bacteria causing bloodstream infection (BSI). The aim of the research was to identify the serotypes, MLST (Multi Locus Sequence Type), virulence genes, and antimicrobial resistance of E. coli isolated from bloodstream infection hospitalized patients in Cipto Mangunkusumo National Hospital Jakarta. We used whole genome sequencing methods rather than the conventional one, to characterized the serotypes, MLST (Multi Locus Sequence Type), virulence genes, and antimicrobial resistance (AMR) of E. coli. The composition of E. coli sequence types (ST) was as follows: ST131 (n=5), ST38 (n=3), ST405 (n=3), ST69 (n=3), and other STs (ST1057, ST127, ST167, ST3033, ST349, ST40, ST58, ST6630). Enteroaggregative E. coli (EAEC) and Extra-intestinal pathogenic E. coli (ExPEC) groups were found dominant in our samples. Twenty isolates carried virulence genes for host cells adherence and 15 for genes that encourage E. coli immune evasion by enhancing survival in serum. ESBL-genes were present in 17 E. coli isolates. Other AMR genes also encoded resistance against aminoglycosides, quinolones, chloramphenicol, macrolides and trimethoprim. The phylogeny analysis showed that phylogroup D is dominated and followed by phylogroup B2. The E. coli isolated from 22 patients in Cipto Mangunkusumo National Hospital Jakarta showed high diversity in serotypes, sequence types, virulence genes, and AMR genes. Based on this finding, routinely screening all bacterial isolates in health care facilities can improve clinical significance. By using Whole Genome Sequencing for laboratory-based surveillance can be a valuable early warning system for emerging pathogens and resistance mechanisms. © 2020 Paramita et al. |
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aminoglycoside antibiotic agent; beta lactam antibiotic; chloramphenicol; macrolide; quinoline derived antiinfective agent; trimethoprim; virulence factor; antibiotic resistance; Article; bacterial gene; bacterial genome; bacterial virulence; bacterium isolate; bloodstream infection; cell adhesion; clinical article; DNA isolation; enteroaggregative Escherichia coli; Escherichia coli; extraintestinal pathogenic Escherichia coli; gene isolation; gene sequence; genetic code; high throughput sequencing; hospital patient; host cell; human; Indonesia; multilocus sequence typing; nonhuman; nuclear magnetic resonance; phylogeny; serotype; virulence gene; whole genome sequencing; bacteremia; bacterial genome; classification; Escherichia coli; Escherichia coli infection; genetics; high throughput se |
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Susiloretni K.A., Smith E.R., Suparmi, Marsum, Agustina R., Shankar A.H. |
55920057100;55479658700;57201388096;57203690495;57214141404;7005442634; |
The psychological distress of parents is associated with reduced linear growth of children: Evidence from a nationwide population survey |
2021 |
PLoS ONE |
16 |
10 October |
e0246725 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118229642&doi=10.1371%2fjournal.pone.0246725&partnerID=40&md5=e63e172d790e5a4d43ab7ba273dd42d6 |
Semarang Health Polytechnic Ministry of Health - Poltekkes Kemenkes Semarang, Central Java, Semarang, Indonesia; Department of Global Health, George Washington University, Washington, D.C., United States; National Health Institute Research and Development, Jakarta, Indonesia; Faculty of Medicine, Department of Nutrition, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Medicine, Human Nutrition Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Nuffield Department of Medicine, The Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom |
Susiloretni, K.A., Semarang Health Polytechnic Ministry of Health - Poltekkes Kemenkes Semarang, Central Java, Semarang, Indonesia; Smith, E.R., Department of Global Health, George Washington University, Washington, D.C., United States; Suparmi, National Health Institute Research and Development, Jakarta, Indonesia; Marsum, Semarang Health Polytechnic Ministry of Health - Poltekkes Kemenkes Semarang, Central Java, Semarang, Indonesia; Agustina, R., Faculty of Medicine, Department of Nutrition, Universitas Indonesia – Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Faculty of Medicine, Human Nutrition Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Shankar, A.H., Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Nuffield Department of Medicine, The Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom |
Background Stunting, an indicator of restricted linear growth, has become a primary measure of childhood undernutrition due to its persistent high prevalence globally, and importance for health and development. Although the etiology is recognized as complex, most analyses have focused on social and biomedical determinants, with limited attention on psychological factors affecting care and nurturing in the home. We assessed whether the psychological distress of parents is related to child linear growth and stunting, and documented the associated risk factors, and examined the relationship between parental distress and behavioral and other risk factors for stunting. Methods We used data from the Indonesia National Health Survey 2013, including 46,315 children 6–59 months of age. Multivariate linear, logistic, and multilevel multinomial logistic regression, using survey weights, were used to assess the relationship between parental distress, as assessed by the WHO Self Reporting Questionnaire (SRQ20), with height-for-age z score (HAZ), stunting, and behavioral and other risk factors for stunting. Results Maternal, paternal and parental distress (i.e. both maternal and paternal distress) were associated with reduced linear growth of the children by 0.086 (95% CI -0.17, -0.00), 0.11 (95% CI -0.24, -0.02) and 0.19 (95% CI -0.37, -0.00) HAZ-scores, respectively. Maternal and paternal distress increased the risk of mild stunting (HAZ <-1) by 33% (95% CI 1.17,1.50) and 37% (95% CI 1.18,1.60), and the risk of moderate stunting (HAZ <-2) by 25% (95% CI 1.10,1.43) and 28% (95% CI 1.08,1.51]), respectively. Parental stress increased the risk of moderate stunting by 40% (95% CI 1.06,1.85). Amongst specific groups of risk factors, the proportion of HAZ-score lost was associated with socioeconomic factors (30.3%) including, low wealth, low maternal occupational status, low maternal education, rural residence, and low paternal occupational status; physiological factors (15.5%) including low maternal height, low maternal mid-upper arm circumference, being male, low paternal height; behavioral factors (8.9%) including open garbage disposal, paternal smoking, not using iodized salt; and experiencing at least one infectious diseases episode (1.1%). Conclusions Maternal, paternal and parental stress were associated with reduced linear growth of children. These findings highlight the complex etiology of stunting and suggest nutritional and other biomedical interventions are insufficient, and that promotion of mental and behavioral health programs for parents must be pursued as part of a comprehensive strategy to enhance child growth and development, i.e. improved caretaker capacity, integrated community development, improved parenting skills, as well as reduced gender discrimination, and domestic violence. © 2021 Susiloretni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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sodium chloride; adult; anthropometric parameters; arm circumference; Article; body height; child; child development; child growth; child parent relation; distress syndrome; domestic violence; education; female; health behavior; health program; health survey; height for age z score; human; Indonesia; infant; infection; male; maternal stress; multivariate logistic regression analysis; occupation; parental stress; paternal smoking; paternal stress; physiology; population; risk factor; rural area; Self Reporting Questionnaire 20; sex ratio; sexism; socioeconomics; stunting; waste disposal; wealth distribution; cross-sectional study; distress syndrome; educational status; growth disorder; nutritional status; physiology; preschool child; prevalence; psychology; rural population; Body Height; Ch |
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Findyartini A., Greviana N., Hanum C., Husin J.M., Sudarsono N.C., Krisnamurti D.G.B., Rahadiani P. |
56543777300;57197709749;57257072300;57221607411;57201862518;55934951600;55524183700; |
Supporting newly graduated medical doctors in managing COVID-19: An evaluation of a Massive Open Online Course in a limitedresource setting |
2021 |
PLoS ONE |
16 |
9 September |
e0257039 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114841740&doi=10.1371%2fjournal.pone.0257039&partnerID=40&md5=d823d8aaf9a69d130347230f477800d5 |
Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sports and Exercise Study, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Center for E-learning, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Findyartini, A., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Greviana, N., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hanum, C., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Husin, J.M., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sudarsono, N.C., Sports and Exercise Study, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Krisnamurti, D.G.B., Center for E-learning, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Pharmacy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rahadiani, P., Center for E-learning, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction Newly graduated medical doctors in their internships are positioned to strengthen the front line in combating COVID-19. We developed a Massive Open Online Course (MOOC) to equip them with adequate knowledge for COVID-19 management. This paper aims to analyze the MOOC and evaluate participant satisfaction and increase in knowledge after completing the course. Methods An observational study was conducted. Quantitative data were obtained from questionnaires and pre-and post-Tests. Responses to open-ended questions of the questionnaires were collected. Analysis using the Quality Reference Framework was also completed. Results The MOOC consisted of fundamental knowledge of COVID-19 (Part A) and further enrichment (Part B), and the content was written in the Indonesian language. A total of 3,424 and 2,462 participants completed the course in August and November 2020, respectively. Most participants agreed that the platform was easy to navigate, the design was interesting, and the content was aligned with their needs. Pre-and post-Test scores in Part A s subjects increased significantly. Factors contributing to and inhibiting usability and areas for improvement were further highlighted. Discussion The use of a specific quality framework facilitated a comprehensive evaluation of the MOOC s strengths, weaknesses, and areas for future improvements. The participants satisfaction and pre-and post-Test results showed that the current MOOC holds great potential benefit for continuing education for medical interns joining the frontliners during the pandemic. Future implementation should consider increasing the quality of learning resources, scaling up the platform and its technical supports, and enhancing organizational supports. © 2021 Public Library of Science. All rights reserved. |
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education; epidemiology; human; Indonesia; medical education; procedures; program evaluation; questionnaire; COVID-19; Education, Distance; Education, Medical, Graduate; Educational Measurement; Humans; Indonesia; Program Evaluation; Surveys and Questionnaires |
Public Library of Science |
19326203 |
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Widodo D.W., Mars R., Suwento R., Alviandi W., Oriza I.I.D., Bardosono S. |
56644646600;57248384300;55743638800;57189731254;57205092885;21933841000; |
Satisfaction and health-related quality of life of patients with microtia following reconstructive surgery using the Nagata technique |
2021 |
PLoS ONE |
16 |
9 September |
e0256652 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114383156&doi=10.1371%2fjournal.pone.0256652&partnerID=40&md5=3f7c84ef725b34720da5ae494a0fc02a |
Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Faculty of Psychology, Universitas Indonesia, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Widodo, D.W., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Mars, R., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Suwento, R., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Alviandi, W., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Oriza, I.I.D., Faculty of Psychology, Universitas Indonesia, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Objective This study aimed to investigate the functional outcomes, satisfaction, and quality of life of patients with microtia following reconstructive surgery. Methods This cross-sectional study was conducted using retrospective data of patients with microtia following reconstructive surgery using the Nagata technique. Data were obtained from the medical records of patients who underwent reconstructive surgery at the Division of Facial Plastic and Reconstructive Surgery, Department of Otorhinolaryngology, Head and Neck Surgery, Dr. Cipto Mangunkusumo Hospital between 2014 and 2018. All eligible patients were referred to participate in this study between November 2018 and March 2019. The hearing function was assessed by a professional audiologist after surgery. Patient satisfaction was evaluated by interview using a previously developed questionnaire, while quality of life was assessed using the EuroQol-5D-Young questionnaire. Results Thirty-one eligible subjects were included in the study. Pain and discomfort were the most commonly reported factors related to the quality of life following surgery. Approximately 67.7% of the patients were satisfied; 19.4% were very satisfied, and 12.9% reported acceptance of their surgical outcomes. The most common complication was infection (n = 8). Most patients did not experience any problems in their lives after microtia surgery. Conclusions The highest rate of satisfactory outcomes was observed for the lobule subunit, which was assumed to be associated with the use of the Z-plasty technique. The most common complication was infection, as environmental hygiene was the most important factor. Thus, further concern for maintaining good hygiene is necessary to improve the quality of reconstructive surgery. The level of satisfaction with microtia reconstructive surgery was adequate. Most patients had a good health-related quality of life without experiencing any problems. © 2021 Widodo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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adolescent; Article; audiologist; child; clinical article; cross-sectional study; ear infection; European Quality of Life 5 Dimensions questionnaire; female; hearing; human; interview; male; medical record; microtia; otalgia; patient referral; patient satisfaction; quality of life; questionnaire; reconstructive surgery; retrospective study; external ear; microtia; patient satisfaction; procedures; psychology; reconstructive surgery; treatment outcome; Adolescent; Child; Congenital Microtia; Cross-Sectional Studies; Ear, External; Female; Humans; Male; Patient Satisfaction; Quality of Life; Reconstructive Surgical Procedures; Retrospective Studies; Treatment Outcome |
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19326203 |
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34469475 |
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990 |
4434 |
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245 |
Yunihastuti E., Hariyanto R., Sulaiman A.S., Harimurti K. |
57221273925;57226819413;57216938482;23473513200; |
Hepatitis C continuum of care: Experience of integrative hepatitis C treatment within a human immunodeficiency virus clinic in Indonesia |
2021 |
PLoS ONE |
16 |
8 August |
e0256164 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112781600&doi=10.1371%2fjournal.pone.0256164&partnerID=40&md5=97994b56bdf101c196e7c76dcd7be446 |
Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; HIV Integrated Clinic, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Yunihastuti, E., Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, HIV Integrated Clinic, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hariyanto, R., Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sulaiman, A.S., Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harimurti, K., Department Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction Direct-acting antiviral drugs (DAAs) have changed the paradigm of hepatitis C therapy for both HCV/HIV co-infected and HCV mono-infected patients. We aimed to describe the HCV continuum of care of HIV-infected patients treated in an HIV clinic after a free DAA program in Indonesia and identify factors correlated with sofosbuvir-daclatasvir (SOF-DCV) treatment failure. Methods We did a retrospective cohort study of adult HIV/HCV co-infected patients under routine HIV-care from November 2019 to April 2020 in the HIV integrated clinic of Cipto Mangunkusumo Hospital, Jakarta, Indonesia. We evaluated some factors correlated with sofosbuvir-daclatasvir treatment failure: gender, diabetes mellitus, previous IFN failure, cirrhosis, concomitant ribavirin use, high baseline HCV-RNA, and low CD4 cell count. Results and discussion Overall, 640 anti-HCV positive patients were included in the study. Most of them were male (88.3%) and former intravenous drug users (76.6%) with a mean age of 40.95 (SD 4.60) years old. Numbers and percentages for the stages of the HCV continuum of care were as follows: HCV-RNA tested (411; 64.2%), pre-therapeutic evaluation done (271; 42.3%), HCV treatment initiated (210; 32.8%), HCV treatment completed (207; 32.2%), but only 178 of these patients had follow-up HCV-RNA tests to allow SVR assessment; and finally SVR12 achieved (178; 27.8%). For the 184 who completed SOF-DCV treatment, SVR12 was achieved by 95.7%. In multivariate analysis, diabetes mellitus remained a significant factor correlated with SOF-DCV treatment failure (adjusted RR 17.0, 95%CI: 3.28–88.23, p = 0.001). Conclusions This study found that in the HCV continuum of care for HIV/HCV co-infected patients, gaps still exist at all stages. As the most commonly used DAA combination, sofosbuvir daclatasvir treatment proved to be effective and well-tolerated in HIV/HCV co-infected patients. Diabetes mellitus was significant factor correlated with not achieving SVR12 in this population. © 2021 Yunihastuti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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antiretrovirus agent; daclatasvir; efavirenz; elbasvir plus grazoprevir; interferon; lopinavir plus ritonavir; nevirapine; ribavirin; simeprevir; sofosbuvir; virus RNA; antivirus agent; adult; Article; CD4 lymphocyte count; cohort analysis; coinfection; controlled study; diabetes mellitus; drug withdrawal; fatigue; female; fever; follow up; gastrointestinal disease; gender; headache; hepatitis C; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; Indonesia; injection drug user; liver cirrhosis; major clinical study; male; multivariate analysis; myalgia; nausea; patient care; pruritus; retrospective study; RNA analysis; sleep disorder; sustained virologic response; university hospital; virus load; coinfection; drug effect; Hepacivirus; hepatitis C; |
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19326203 |
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34383853 |
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