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Mukti A.I., Ilyas S., Warli S.M., Putra A., Rasyid N., Munir D., Siregar K.B., Ichwan M., Alif I., Hidayah N. |
57376899500;55980597400;57189610001;57197818079;56245069300;57039203600;57190863373;26040779000;57215218352;57377826800; |
Mesenchymal stem cells enhance vascular endothelial growth factor-A, endothelial nitric oxide synthetase, and HSP70 expression in improving erectile dysfunction in streptozotocin-induced diabetic rats |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1174 |
1180 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121417031&doi=10.3889%2foamjms.2021.7801&partnerID=40&md5=d2741187724b6c10a2d9b17fcabd3aad |
Department of Doctoral Degree Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia; Department of Urology, Faculty of Medicine, Universitas Sumatera Utara Hospital, Medan, Indonesia; Stem Cell and Cancer Research, Faculty of Medical, Sultan Agung Islamic University, Semarang, Indonesia; Department of Pathology, Medical Faculty, Sultan Agung Islamic University, Semarang, Indonesia; Department of Postgraduate Biomedical Science, Medical Faculty, Sultan Agung Islamic University, Semarang, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Pusat Unggulan IPTEK Tissue Engineering, Universitas Sumatera Utara, Medan, Indonesia; Department of Oncology Surgery, Faculty of Medicine, Universitas Sumatera Utara, Universitas Sumatera Utara Hospital, Medan, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia |
Mukti, A.I., Department of Doctoral Degree Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Ilyas, S., Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia; Warli, S.M., Department of Urology, Faculty of Medicine, Universitas Sumatera Utara Hospital, Medan, Indonesia; Putra, A., Stem Cell and Cancer Research, Faculty of Medical, Sultan Agung Islamic University, Semarang, Indonesia, Department of Pathology, Medical Faculty, Sultan Agung Islamic University, Semarang, Indonesia, Department of Postgraduate Biomedical Science, Medical Faculty, Sultan Agung Islamic University, Semarang, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Munir, D., Department of Doctoral Degree Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia, Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia, Pusat Unggulan IPTEK Tissue Engineering, Universitas Sumatera Utara, Medan, Indonesia; Siregar, K.B., Department of Oncology Surgery, Faculty of Medicine, Universitas Sumatera Utara, Universitas Sumatera Utara Hospital, Medan, Indonesia; Ichwan, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Alif, I., Stem Cell and Cancer Research, Faculty of Medical, Sultan Agung Islamic University, Semarang, Indonesia; Hidayah, N., Stem Cell and Cancer Research, Faculty of Medical, Sultan Agung Islamic University, Semarang, Indonesia |
AIM: This study investigated the therapeutic role of mesenchymal stem cells (MSCs) on erectile function in a diabetes mellitus erectile dysfunction (DMED) rat model by analyzing the expression of endothelial nitric oxide synthetase (eNOS), vascular endothelial growth factor A (VEGF-A), and the 70 kilodalton heat shock proteins (HSP70). METHODS: MSCs were isolated from umbilical cords (UCs), and their characteristics identified by flow cytometry and osteogenic differentiation analysis. Thirty 8-week-old rats were divided into four groups: Sham, control, T1, and T2. After a 16 h fast, 24 rats were randomly selected and intraperitoneally injected with streptozotocin (STZ) to induce diabetes mellitus. At 8 weeks after STZ injection, rats with DMED were classified into four groups, sham, control group (DMED rats received 500 μL phosphate buffer saline [PBS]); T1 (DMED rats treated with 500 μL PBS containing 1 × 106 UC-MSCs); and T2 (DMED rats treated with 500 μL PBS containing 2 × 106 UC-MSCs). Eight weeks after MSCs administration, the rats’ erectile function was measured by cavernous nerve stimulation. The blinded histological and gene expression assessment were used to analyze the eNOS, HSP70 content, and VEGF-A expression on the penile tissues. RESULTS: MSCs administration, rats in T1 and T2 groups showed a significant enhancement of erectile response that showed a trend of increase of VEGF-A mRNA level expression was 2.2 ± 0.61 in T2 Group supported with the optimum recovery of eNOS, in which the value of eNOS expression was 20.66% ± 2.32%. While optimum decrease of HSP70 content, the value of HSP70 expression was 15.50% ± 0.90%. IHC results showed that the DMED induction in rats caused a significant decrease of eNOS content in corpus cavernosum tissue. CONCLUSION: MSCs could ameliorate DMED in rats by increasing VEGF-A and decreasing HSP70 and eNOS, indicating these cells offer a potential application for DMED patients’ treatment. © 2021 Ade Indra Mukti, Syafruddin Ilyas, Syah Mirsya Warli, Agung Putra, Nur Rasyid, Delfitri Munir, Kamal Basri Siregar, Muhammad Ichwan, Iffan Alif, Nurul Hidayah. |
Endothelial nitric oxide synthetase; Erectile dysfunction; HSP70; Mesenchymal stem cells; Vascular endothelial growth factor A-A |
heat shock protein; heat shock protein 70; messenger RNA; nitric oxide synthase; vasculotropin A; animal cell; animal experiment; animal model; animal tissue; Article; cell differentiation; controlled study; corpus cavernosum; erectile dysfunction; female; flow cytometry; gene expression; glucose blood level; histology; hypoglycemia; immunohistochemistry; International Index of Erectile Function; lipid storage; male; mesenchymal stem cell; nerve stimulation; nonhuman; polymerase chain reaction; protein expression; rat; real time polymerase chain reaction; Sertoli cell; streptozotocin-induced diabetes mellitus |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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661 |
Andreas A.M., Djuwita R., Helda H., Sekartni R., Suradijono S.H.R., Wiguna T., Tulaar A.B.M., Kristianto Y., Hendrik H. |
57356220700;56586138300;57195467249;57355240300;57209473358;57356086800;24330360800;57356220800;57355801600; |
Massage therapy can prevent the risk of autism spectrum disorders in children |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1556 |
1560 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120032396&doi=10.3889%2foamjms.2021.7436&partnerID=40&md5=ca9744bb24e561c7ddfc3916dd11ecc2 |
Faculty of Public Health, University of Indonesia, Jakarta, Indonesia; Department of Pediatrics and Development, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Developmental Psychology, Faculty of Psychology, University of Indonesia, Jakarta, Indonesia; Department of Child Psychiatry, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Medical Rehabilitation, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Health Polytechnic, Ministry of Health Jakarta 1, Jakarta, Indonesia; Department of Physiotherapy, Health Polytechnic, Ministry of Health Makassar, Makassar, Indonesia |
Andreas, A.M., Faculty of Public Health, University of Indonesia, Jakarta, Indonesia; Djuwita, R., Faculty of Public Health, University of Indonesia, Jakarta, Indonesia; Helda, H., Faculty of Public Health, University of Indonesia, Jakarta, Indonesia; Sekartni, R., Department of Pediatrics and Development, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Suradijono, S.H.R., Department of Developmental Psychology, Faculty of Psychology, University of Indonesia, Jakarta, Indonesia; Wiguna, T., Department of Child Psychiatry, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Tulaar, A.B.M., Department of Medical Rehabilitation, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Kristianto, Y., Health Polytechnic, Ministry of Health Jakarta 1, Jakarta, Indonesia; Hendrik, H., Department of Physiotherapy, Health Polytechnic, Ministry of Health Makassar, Makassar, Indonesia |
BACKGROUND: The prevalence of human beings with autism spectrum issues in some parts of the world tends to make bigger, in Indonesia alone, accurate and complete data and information from human beings with autism spectrum disorders (ASD) are nonetheless missing, so it is feared that many children with risk symptoms of ASD do not get treatment early. AIM: This research aims to prevent the risk of ASD in children through making use of massage therapy remedies based on evaluation of the Modified Checklist for Autism in Toddler (modified Chat [M-Chat]) ratings. METHODS: This research is a quasi-experimental study with a time series design which was carried out from May 2019 to March 2020 at three health centers in the city of Jakarta. The analysis was carried out before and after the application of massage in a time series of four periods on ten children aged 18–36 months with M-Chat scores, and then analyzed by receiver operating characteristics to obtain a cutoff point to determine the risk status of ASD. RESULTS: The results showed that there was an effect of massage therapy on the M-Chat score of children with ASD risk p = 0.004 < 0.05 and changes in the M-Chat score of children with ASD risk experienced significant changes after massage in the third and fourth therapy periods with p = 0.005 and p = 0.007 < 0.05. CONCLUSION: The results show that massage therapy can prevent of autism spectrum issues in children based on the Modified Checklist for Autism in Toddler (M-Chat). © 2021 Andy Martahan Andreas, Ratna Djuwita, Helda Helda, Rini Sekartni, Sri Hartati R. Suradijono, Thjin Wiguna, Angela B. M. Tulaar, Yusuf Kristianto, Hendrik Hendrik. |
Autism spectrum disorders; Babies; Massage therapy; Modified checklist for autism in toddler |
Article; autism; cesarean section; checklist; child; chromosome aberration; female; health center; human; human experiment; Indonesia; male; massage; pH; predictive value; preschool child; prevalence; prospective study; QT interval; quasi experimental study; receiver operating characteristic; scoring system; sensitivity and specificity; time series analysis; toddler |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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719 |
Habiburrahman M., Ariq H., Yusharyahya S.N. |
57204537114;57252668400;57211780941; |
The role of lipid and the benefit of statin in augmenting rifampicin effectivity for a better leprosy treatment |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
F |
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246 |
259 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114611520&doi=10.3889%2foamjms.2021.6263&partnerID=40&md5=1f7a547ae466b610bf3ce7e833b58a56 |
Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
Habiburrahman, M., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Ariq, H., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Yusharyahya, S.N., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
BACKGROUND: Although leprosy remains as a serious disease of the skin and nervous system, the current treatment is still lacking in its effectiveness. AIM: This literature review will explore the association of lipid and leprosy, as well as the potential of statin and other lipid-lowering agents as adjunctive drugs to combat leprosy. MATERIALS AND METHODS: Articles were searched through the PubMed, EBSCOhost, and Google Scholar with the keywords: immunomodulation, lipid-body, lipids, leprosy, Mycobacterium leprae, pathogenesis, rifampin or rifampicin, and statins. A manual searching is also carried out to find an additional relevant information to make this literature review more comprehensive. RESULTS: The literatures showed that lipids are highly correlated with leprosy through alterations in serum lipid profile, metabolism, pathogenesis, and producing oxidative stress. Statins can diminish lipid utilization in the pathogenesis of leprosy and show a mycobactericidal effect by increasing the effectiveness of rifampicin and recover the function of macrophages. In addition, Statins have anti-inflammatory properties which may aid in preventing type I and II reactions in leprosy. Standard multidrug therapy might reduce the efficacy of statins, but the effect is not clinically significant. The statin dose-response curve also allows therapeutic response to be achieved with minimal dose. CONCLUSION: The various pleiotropic effects of statins make it a potential adjunct to standard treatment for leprosy in the future. © 2021 Muhammad Habiburrahman, Haekal Ariq, Shannaz Nadia Yusharyahya. |
Anti-inflammatory; Bactericidal; Leprosy; Lipids; Rifampicin; Statins |
hydroxymethylglutaryl coenzyme A reductase inhibitor; interleukin 10; mevalonic acid; rifampicin; Article; human; immunomodulation; inflammation; lepromatous leprosy; leprosy; lipid metabolism; macrophage; macrophage function; Mycobacterium leprae; oxidative stress; phagocytosis; physiological stress; pleiotropy; polypharmacy; sensitivity and specificity; systematic review; treatment response; tuberculoid leprosy |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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738 |
Ardinata D., Zain-Hamid R., Roesyanto-Mahadi I.D., Mihardja H. |
57201518818;8059724800;57222900126;57195721818; |
Interleukin-31 serum and pruritus dimension after acupuncture treatment in hemodialysis patients: A randomized clinical trial |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
B |
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196 |
201 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112120177&doi=10.3889%2foamjms.2021.5599&partnerID=40&md5=a48058e1ca315a987857bbabd6864b39 |
Department of Physiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Ardinata, D., Department of Physiology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Zain-Hamid, R., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Roesyanto-Mahadi, I.D., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Mihardja, H., Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Interleukin (IL)-31 serum levels were significantly higher in hemodialysis patients with pruritus, whereas acupuncture in LI11 was shown to improve symptoms of pruritus. However, there is limited information that IL-31 serum levels that correlate with decreased dimensions of the pruritus after acupuncture in LI11 in a hemodialysis patient. AIM: The aim of the study was to demonstrate the impact of acupuncture in LI11 and IL-31 serum level and its correlation with dimensions of the pruritus in hemodialysis patients. METHODS: A randomized clinical trial has been carried out from August 2019 to December 2019 at H. Adam Malik General Hospital, Medan, Indonesia. Sixty patients underwent hemodialysis who were randomly allocated to two groups, one group got acupuncture in Quchi LI11 (intervention group), and the other group got a placebo (control group). IL-31 serum levels and pruritus were measured before and after 6 weeks of acupuncture in both groups. RESULTS: Acupuncture did not significantly reduce IL-31 (p = 0.931) and decreased dimensions: Degree, duration, disability, and distribution of the pruritus between the intervention group and the control group after 6 weeks of acupuncture in LI11. It can be shown that there is no significant correlation between IL-31 serum levels and dimensions of the pruritus. CONCLUSION: This study demonstrates the effect of acupuncture on reducing dimensions of the pruritus not related to IL-31 serum levels. Identifying the action mechanism of acupuncture to minimize pruritus considerably enhances knowledge of the impacts of acupuncture on reducing pruritus in hemodialysis patients. © 2021 Dedi Ardinata, Rozaimah Zain-Hamid, Irma. D. Roesyanto-Mahadi, Hasan Mihardja. |
Acupuncture; Hemodialysis; Interleukin 31; LI11 Quchi; Pruritus |
bicarbonate; C reactive protein; chemical compound; hemoglobin; interleukin 31; naltrexone; polysulphane; tumor necrosis factor; unclassified drug; acupuncture; adult; Article; atopic dermatitis; body mass; controlled study; data analysis; diabetic nephropathy; disability; disease severity; enzyme linked immunosorbent assay; female; hemodialysis; hemodialysis patient; histamine release; human; hypertension; iontophoresis; kidney disease; major clinical study; male; middle aged; percutaneous coronary intervention; protein blood level; pruritus; psoriasis; quchi acupoint; questionnaire; randomized controlled trial; scoring system; urticaria; visual analog scale |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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759 |
Ertandri L., Hamid A.R.A.H., Saraswati M., Mochtar C.A., Umbas R. |
57226072007;57202054669;57208472364;6506558321;6602634832; |
Open versus percutaneous approach of renal tumor biopsy at cipto mangunkusumo hospital: A single-center experience |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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547 |
551 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110263491&doi=10.3889%2foamjms.2021.6038&partnerID=40&md5=1dba3a8b193172b4b556c059d687c1e8 |
Department of Urology, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Pathology Anatomy, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Ertandri, L., Department of Urology, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hamid, A.R.A.H., Department of Urology, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Saraswati, M., Department of Pathology Anatomy, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Mochtar, C.A., Department of Urology, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Umbas, R., Department of Urology, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
BACKGROUND: Renal tumor biopsy is beneficial as it is capable of distinguishing between histological types of renal tumor; hence, it plays an important role in deciding the best therapy regimen. AIM: This study aims to evaluate the clinical experiences of renal biopsy in Cipto Mangunkusumo National Referral Hospital (RSCM), with both a percutaneous and open approach. It also aims to analyze the indications, results, intraoperative information, and complications of the two approaches. METHODS: This study was conducted using the retrospective cohort design; meanwhile, data were collected from RSCM from 1990 to 2019. The biopsy sample was taken using percutaneous and open renal biopsy, while comparative analysis was done between the two biopsy approaches. RESULTS: Data were collected from 33 patients that underwent renal biopsy from 1990 to 2019. Majority of the cases were diagnosed as unresectable renal tumor, while histological examination found clear cell carcinoma in most of the cases (73%). Furthermore, the open approach showed longer duration and higher blood loss compared to percutaneous technique with median 60 (30–120) versus 30 (5–60) min (p < 0.001) and 100 (5–650) versus 2 (1–5) ml (p < 0.001), respectively. In general, complications were reported to be low for both techniques. CONCLUSION: Based on the results, percutaneous renal biopsy has similar efficacy and complications rates in tumor sampling for histopathology together with open approach. However, there were significant differences in the duration and blood loss; hence, percutaneous biopsy is more favorable. © 2021 Luki Ertandri, Agus Rizal A. H. Hamid, Meilania Saraswati, Chaidir A. Mochtar, Rainy Umbas. |
Comparative analysis; Complications; Open approach; Percutaneous approach; Renal tumor biopsy |
cefoperazone plus sulbactam; ceftriaxone; adult; aged; Article; bleeding; blood transfusion; cancer staging; clear cell renal cell carcinoma; clinical article; clinical evaluation; cohort analysis; comparative study; female; fine needle aspiration biopsy; general anesthesia; hematuria; histology; histopathology; human; human tissue; kidney biopsy; kidney tumor; local anesthesia; male; needle biopsy; open biopsy; operation duration; operative blood loss; percutaneous biopsy; peroperative complication; real time echography; retrospective study; sepsis; squamous cell carcinoma; transitional cell carcinoma; tumor biopsy; urinary tract infection |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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773 |
Rahman Y., Krisanti R.I.A., Wisnu W., Sitohang I.B.S. |
57225022226;57210797305;57200425452;56734569200; |
The comparison between free thyroxine and thyroid-stimulating hormone levels on melasma severity: A cross-sectional study |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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426 |
431 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108964003&doi=10.3889%2foamjms.2021.5952&partnerID=40&md5=b495093253a6b484fb6b524298865e4d |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia |
Rahman, Y., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia; Krisanti, R.I.A., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia; Wisnu, W., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia; Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia |
BACKGROUND: Melasma has been suspected to be linked with levels of thyroid hormone. There is no study that explains the association between thyroid hormone levels with melasma severity. AIM: This study aims to find the discrepancies in the levels of thyroid hormone in varying severity of melasma using two different measurement techniques. METHODS: Subjects were chosen consecutively from the dermatology clinic at RSUPN Dr. Cipto Mangunkusumo hospital. Forty-eight patients participated in this study were categorized into mild melasma and moderate-severe melasma based on modified melasma area and severity index (mMASI) and Janus II measurement. RESULTS: Statistically, mMASI measurement showed no significant association between varying melasma severity with levels of thyroid stimulating hormone and free T4 (FT4), p = 0.375 and p = 0.208, respectively. The Janus II examination using polarized light modality has a weak positive correlation with the serum FT4 level (r = 0.3; p = 0.039). Weak correlation was also found between the two measurement strategies, Janus II and mMASI (r = 0.314; p = 0.03). CONCLUSION: There are no significant differences observed in levels of thyroid hormone between subjects with varying degrees of melasma severity. © 2021 Yusnita Rahman, Roro Inge Ade Krisanti, Wismandari Wisnu, Irma Bernadette S. Sitohang. |
Free T4; Janus II facial analysis system; Melasma; Modified melasma area and severity index; Thyroid-stimulating hormone |
thyrotropin; adult; Article; chloasma; clinical article; cross-sectional study; disease severity; female; free thyroxine index; human; male |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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789 |
Rhatomy S., Dilogo I.H. |
57204509883;56161962800; |
Core decompression and biological treatment in osteonecrosis of the hip due to systemic lupus erythematosus, 8-year follow-up: A case report |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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74 |
79 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107632892&doi=10.3889%2foamjms.2021.5798&partnerID=40&md5=d126812c5dab6196ca3a6f0a5513b86a |
Department of Orthopaedic and Traumatology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Soeradji Tirtonegoro General Hospital, Yogyakarta, Indonesia; Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rhatomy, S., Department of Orthopaedic and Traumatology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Soeradji Tirtonegoro General Hospital, Yogyakarta, Indonesia; Dilogo, I.H., Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Osteonecrosis most commonly affects the femoral head, especially in middle-aged adults. It can be caused by trauma, chronic inflammation, or infection. It leads to collapse of the entire femoral head and culminates with total hip replacement. CASE REPORT: A 29-year-old female with systemic lupus erythematosus (SLE) had a chief complaint of bilateral hip pain. She was diagnosed with early osteonecrosis of the femoral head (FICAT stage II) using magnetic resonance imaging and core decompression surgery was performed using three small diameter (4 mm) drillings and added biological treatment. She was evaluated with a visual analog scale (VAS), Harris hip score (HHS), and plain radiography in the pre-operative stage and post-operative follow-up. RESULTS: Functional outcome at 8-year follow-up showed improvement with significantly decreased VAS (pre-operative: 5, post-operative: 0), significant improvement of HHS from 52.725 points (poor) pre-operative to 92.025 points (excellent) post-operative, and subsided femoral head lesion. CONCLUSIONS: Surgical decompression and biological treatment result in decreased intraosseous pressure and enhanced osteogenesis. It can restrict the SLE disease progression and limit the number of cell death. © 2021 Sholahuddin Rhatomy, Ismail Hadisoebroto Dilogo. |
Avascular necrosis; Core decompression; Hip; Osteonecrosis; Systemic lupus erythematosus |
corticosteroid; adult; antalgic lump; arteriovenous shunt; Article; avascular necrosis; bone development; bone graft; bone necrosis; bone radiography; case report; clinical article; clinical examination; daily life activity; decompression surgery; differential diagnosis; disease exacerbation; female; femoral head; fluoroscopy; follow up; functional outcome; Harris hip score; hip osteoarthritis; hip pain; hip replacement; human; intermittent pain; morphogenesis; nuclear magnetic resonance imaging; ossification; osteogenesis imperfecta; physical examination; preoperative evaluation; range of motion; systemic lupus erythematosus; thigh region; visual analog scale; weight bearing |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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793 |
Sitohang I.B.S., Nelson B., Marissa M., Indriatmi W., Wisnu W. |
56734569200;57222619613;57210795916;57189888041;57200425452; |
Evaluation of modified melasma area and severity index in hyperthyroid patients receiving anti-thyroid drugs |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
B |
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344 |
349 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107477787&doi=10.3889%2foamjms.2021.6082&partnerID=40&md5=ecf1548d04f6591bb645bfc03792883e |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Metabolic Endocrine Division, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nelson, B., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Marissa, M., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Indriatmi, W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wisnu, W., Department of Internal Medicine, Metabolic Endocrine Division, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND: Melasma is a common hyperpigmentation disorder, which causes brownish discoloration of the face. Despite unclear mechanisms, thyroid hormones were thought to play a role in melasma. AIM: This study aims to determine and compare the clinical improvement of melasma in hyperthyroid patients receiving anti-thyroid drugs. METHODS: An interventional study with a quasi-experimental design (pre-post-intervention study) was conducted at the Internal Medicine Outpatient Clinic and Dermatology and Venereology Outpatient Clinic, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, from July 2019 to March 2020. A comparative analysis was done to compare the modified melasma area and severity index (mMASI) in hyperthyroid patients before and after 12 weeks of anti-thyroid drugs. All subjects did not receive any additional topical therapies for their melasma. The clinical features were evaluated objectively at baseline and 12th-week visit, by mMASI score on different areas of the face (forehead, left-right malar, and chin) and Wood’s lamp examination. RESULTS: All areas showed a decline in mMASI score components (e.g., involvement areas and darkness degree) after 12 weeks of treatment. However, only the malar area showed a significant decline (p < 0.05). Wood’s lamp examination at baseline revealed dermal type melasma on 17 subjects, mixed type on six subjects, and epidermal type on one subject. All types remained unchanged after 12 weeks of treatment. CONCLUSIONS: Our study demonstrated that mMASI score in malar area improved significantly, this might be because malar area included this study were comprised of epidermal, dermal, and mixed type. On the other hand, based on Wood’s lamp examination, all types of melasma remained unchanged after 12 weeks of treatment. © 2021 Irma Bernadette S. Sitohang, Benny Nelson, Melani Marissa, Wresti Indriatmi, Wismandari Wisnu. |
Hyperthyroid; Melasma; Modified melasma area and severity index; Wood’s lamp |
amiodarone; antithyroid agent; octreotide; thiamazole; thyroid hormone; adult; Article; chloasma; clinical article; clinical assessment; clinical feature; dermatology; experimental design; female; follow up; forehead; human; hyperpigmentation; hyperthyroidism; intervention study; male; observational study; outpatient department; prospective study; thyroid disease; thyroid function test; topical treatment; visual analog scale |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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796 |
Pontoh L.A.P., Ismail H.D., Fiolin J., Yausep O.E. |
57192907426;57224810749;57194498274;57200086151; |
Pain following single-bundle versus double-bundle anterior cruciate ligament reconstruction: A systematic review |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
|
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153 |
162 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107326267&doi=10.3889%2foamjms.2021.5995&partnerID=40&md5=907e110a1eb993238ca4374c25cdcb6a |
Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Fatmawati General Hospital, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Jakarta Knee Orthopaedic Sports Center, Pondok Indah Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Pontoh, L.A.P., Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Fatmawati General Hospital, Jakarta, Indonesia; Ismail, H.D., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Fiolin, J., Jakarta Knee Orthopaedic Sports Center, Pondok Indah Hospital, Jakarta, Indonesia; Yausep, O.E., Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND: Double-bundle (DB) anterior cruciate ligament reconstruction (ACLR) has been known to result in better functional outcomes, joint stability, and lower revision rates compared to single-bundle (SB) ACLR. However, given the increased invasiveness and damage to the surrounding tissue area, it is proposed that it may be associated with increased pain. AIM: This review aims to gather all studies and literature that reported pain as an outcome when comparing SB versus DB ACLR. METHODS: Literature searching was conducted across seven search engines for studies reporting pain as an outcome and comparing SB versus DB ACLR. RESULTS: Eight studies met the eligibility criteria and were included in the study. Overall, the studies show variable findings regarding pain in DB compared to SB ACLR, with the only statistically significant results from two studies indicating that DB ACLR is associated with more pain than SB ACLR. CONCLUSION: Based on the limited evidence available, no conclusions can be made regarding the pain experienced between people receiving either procedure. This constitutes a need for additional studies with increased follow-up time periods, larger sample size, and better study design. © 2021 Ludwig A. P. Pontoh, H. D. Ismail, Jessica Fiolin, Oliver Emmanuel Yausep. |
Anterior cruciate ligament; Double bundle; Pain; Reconstruction; Single bundle |
analgesic agent; anesthetic agent; anesthesia; anterior cruciate ligament injury; anterior cruciate ligament reconstruction; collateral ligament; data analysis; data extraction; follow up; gracilis flap; hamstring muscle; hamstring tendon; human; joint stability; knee ligament; knee meniscus rupture; knee pain; ligament surgery; meta analysis; operation duration; pain; randomized controlled trial (topic); Review; systematic review; tendon graft; visual analog scale |
Scientific Foundation SPIROSKI |
18579655 |
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Review |
Q3 |
288 |
15252 |
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876 |
Sari I.P., Audindra S., Zhafira A.S., Rahma A.A., Syarira C.V., Wahdini S. |
57197543698;57222006228;57205515532;57222005612;57222010715;57203684068; |
Nutritional status of school-aged children with intestinal parasite infection in South Jakarta, Indonesia |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
E |
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95 |
100 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100938719&doi=10.3889%2foamjms.2021.5711&partnerID=40&md5=1772780d39afba8ba66dd65e8997f0b4 |
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sari, I.P., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Audindra, S., Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Zhafira, A.S., Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahma, A.A., Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Syarira, C.V., Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wahdini, S., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: The prevalence of intestinal parasitic infection still high in Indonesia and lead to nutritional disorder, especially in the school-aged children. AIM: This research conducted to find the association of intestinal parasitic infection to the nutritional status of the children. METHODS: This was a cross sectional study, conducted in January 2016 in one primary school in South Jakarta, Jakarta, Indonesia, by collecting the children’s stool from 1st to 5th grade. Direct examination of the stool was conducted in the Parasitology Department, Faculty of Medicine, Universitas Indonesia, by Lugol and eosin staining. Nutritional status categorized using BMI chart. Data were analyzed using Chi-square test, Statistical Product, and Service Solutions version 20. RESULTS: From the total 157 stool examined in the laboratory, there were 60 (38.2%) children positively infected with various kinds of intestinal parasites. Mostly the infection is caused by Blastocystis hominis, which infects 44 children (69.4%). The other infection is caused by Giardia lamblia (15.3%), Trichuris trichiura (1.4%), and hookworm (1.4%), and mixed infection of B. hominis and Escherichia coli (4.2%) and B. hominis with G. lamblia (4.2%). From the total of infected children, 17 children (28.3%) have BMI below 5th percentile, and it was considered as malnourished. Moreover, 67 uninfected children have normal nutritional status. Statistically, there is an association between intestinal parasitic infection and nutritional status in school-aged children in South Jakarta (P < 0.05). CONCLUSION: The incidence of intestinal parasitic infection in school-aged children is 38.2%. Moreover, 28.3% of the infected children were malnourished and it is suggested that children with intestinal parasite infection have low nutritional status. © 2021 Ika Puspa Sari, Sacha Audindra, Aqila S. Zhafira, Arin A. Rahma, Cut V. Syarira, Sri Wahdini. |
Malnourish; Parasitic Infection; Primary Schools; South Jakarta |
Article; Blastocystis hominis; body mass; child; cross-sectional study; disease association; Escherichia coli; feces analysis; female; Giardia intestinalis; human; Indonesia; intestine parasite; major clinical study; male; malnutrition; mixed infection; nutritional status; obesity; parasitosis; prevalence; primary school; questionnaire; seasonal variation; Trichuris trichiura; underweight |
Open Access Macedonian Journal of Medical Sciences |
18579655 |
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Article |
Q3 |
288 |
15252 |
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