|
No records
|
|
711 |
Atmakusuma T.D., Tenggara J.B. |
57216961785;26028154300; |
Correlation of transferrin saturation and serum ferritin with bone mass density in adult transfusion dependent beta-thalassemia patients |
2021 |
Journal of Blood Medicine |
12 |
|
|
827 |
832 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115292368&doi=10.2147%2fJBM.S328547&partnerID=40&md5=136e30d4eafe0cf460ffe633d41e4fd8 |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, MRCCC Siloam Hospital Jakarta, Jakarta, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tenggara, J.B., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Division of Hematology-Medical Oncology, Department of Internal Medicine, MRCCC Siloam Hospital Jakarta, Jakarta, Indonesia |
Background: The use of regular blood transfusions and iron chelation therapy to treat thalassemia has improved survival and increased the incidence of osteoporosis. Moreover, iron toxicity is one of the contributing factors that reduce bone mass density in adult transfusion-dependent beta-thalassemia patients. Therefore, this study aims to determine the proportion of low bone mass density in adult thalassemia patients and transferrin saturation, as well as serum ferritin, which correlates to the skeletal condition. Methods: This is a cross-sectional study conducted in Thalassemia and Hematology Medical Oncology Clinics of Cipto Mangunkusumo Hospital in March 2016. The anthropo-metric data and hemoglobin levels were obtained before transfusion. Subsequently, the average ferritin levels, bone mineral density, and radiographic results were obtained. Results: The percentage of adult thalassemia major and intermedia patients with low bone mass density was 68%. Also, there was a weak inverse correlation between bone mass density and transferrin saturation (r = −0.329, p = 0.01), while no correlation was shown between bone mass density and ferritin (r = −0.088, p = 0.504). The transferrin saturation cutoff point value used to distinguish the incidence of low and normal bone density in patients with transfusion-dependent beta-thalassemia was 89.5%. In addition, there was weak correlation between Singh index and bone mass density (r = 0.273, p = 0.038). Conclusion: Among the transfusion-dependent beta-thalassemia patients, 68% had low bone mass density, which inversely correlated to transferrin saturation. Furthermore, the cutoff value of transferrin saturation to differentiate the incidence of low and normal bone density in thalassemia major compared to thalassemia intermedia was 89.5%. Singh Index correlates weakly with bone mass density and might be used to detect low bone mass density in remote healthcare facilities. © 2021 Atmakusuma and Tenggara. |
Bone mass density; Ferritin; Thalassemia; Transferrin; Transfusion dependent beta |
C reactive protein; calcium; chloride; magnesium; phosphate; potassium; sodium; adult; aged; anthropometry; Article; beta thalassemia; blood transfusion; bone densitometry; bone density; correlational study; cross-sectional study; dual energy X ray absorptiometry; female; ferritin blood level; hemoglobin blood level; human; major clinical study; male; radiography; receiver operating characteristic; scoring system; sensitivity and specificity; singh index; transferrin saturation |
Dove Medical Press Ltd |
11792736 |
|
|
Article |
Q3 |
676 |
7401 |
|
|
|
712 |
Rohsiswatmo R., Azharry M., Sari T.T., Bahasoan Y., Wulandari D. |
55533574600;57263156500;36519483600;57263337000;57204024903; |
TLR2 and TLR4 expressions in late-onset neonatal sepsis: Is it a potential novel biomarker? |
2021 |
Journal of Neonatal-Perinatal Medicine |
14 |
3 |
|
361 |
367 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115150896&doi=10.3233%2fNPM-200411&partnerID=40&md5=6cf4f414e02f524e32c55a2f9864c09a |
Department of Child Health, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Rohsiswatmo, R., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Azharry, M., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sari, T.T., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bahasoan, Y., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wulandari, D., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND: Late-onset neonatal sepsis (LONS) detection is problematic as no single examinations (blood culture, c-reactive protein (CRP), procalcitonin (PCT)) are reliable. Toll-like receptors (TLRs), which detect the presence of pathogen-associated molecular patterns is a promising novel biomarker, but less studied in LONS. This study aimed to determine neutrophils and monocytes TLR2 and TLR4 expression in LONS and their diagnostic value. METHODS: A cross-sectional study conducted in May and June 2017 involving 52 neonates with clinical late-onset (>72 hours of age) sepsis. We examine complete blood count, I/T ratio, CRP, PCT, as well as TLR2 and TLR4 expression to compared with blood culture as the gold standard. We classified cases into proven or unproven sepsis. RESULT: The incidence of LONS was 32.6% in the subjects. The expression of TLR2 was low in LONS, while TLR4 was high. TLR4 neutrophil expression has 88.2% sensitivity, 20% specificity, 34.9% positive predictive value (PPV), 77.8% negative predictive value (NPV), and an AUC of 0.541. TLR4 monocyte expression has 92.1% sensitivity, 11.4% specificity, 34% PPV, 80% NPV, and an AUC of 0.528. The AUC of CRP is increased from 0.608 to 0.843 after combination with TLR4, comparable with CRP + PCT (AUC 0.829). CONCLUSION: The increase in TLR4 expression has good sensitivity but low specificity. TLR4 expression, in combination with CRP, could become a reliable biomarker for the diagnosis of LONS. © 2021-IOS Press. All rights reserved. |
biomarker; c-reactive protein; Late-onset neonatal sepsis; procalcitonin; TLR2; TLR4 |
biological marker; C reactive protein; procalcitonin; toll like receptor 2; toll like receptor 4; biological marker; C reactive protein; TLR2 protein, human; TLR4 protein, human; toll like receptor 2; toll like receptor 4; Acinetobacter baumannii; Article; blood cell count; blood culture; controlled study; cross-sectional study; diagnostic test accuracy study; diagnostic value; female; gold standard; human; Klebsiella pneumoniae; late onset disorder; low birth weight; major clinical study; male; monocyte count; neutrophil count; newborn; newborn sepsis; nonhuman; predictive value; protein expression; receiver operating characteristic; sensitivity and specificity; sepsis; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Humans; Infant, Newborn; Neonatal Sepsis; Sepsis; Toll-Like Rec |
IOS Press BV |
19345798 |
|
33164948 |
Article |
Q2 |
444 |
11146 |
|
|
|
713 |
Mulyadi R., Hatta M., Islam A.A., Murtala B., Tammase J., Firdaus M., Susanto E., Prihartono J. |
56403164500;8134403900;55504893500;57216630400;57216632154;57220366722;57204423225;6602605635; |
Intratumoral and Peritumoral Apparent Diffusion Coefficient and MGMT mRNA Expression in Different Meningioma Histopathological Grade |
2021 |
Indonesian Biomedical Journal |
13 |
1 |
|
97 |
105 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115108397&doi=10.18585%2finabj.v13i1.1338&partnerID=40&md5=22848104129d76ff75e6024180be5997 |
Neuroradiology Division, Department of Radiology, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Molecular Biology and Immunology Laboratory, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM 10, Makassar, 90245, Indonesia; Department of Neurosurgery, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM 10, Makassar, 90245, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM 10, Makassar, 90245, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM 10, Makassar, 90245, Indonesia; Department of Neurosurgery, Dharmais Hospital National Cancer Center, Jl. Letjen Jend. S. Parman No.84-86, Jakarta, 11420, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia |
Mulyadi, R., Neuroradiology Division, Department of Radiology, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Hatta, M., Molecular Biology and Immunology Laboratory, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM 10, Makassar, 90245, Indonesia; Islam, A.A., Department of Neurosurgery, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM 10, Makassar, 90245, Indonesia; Murtala, B., Department of Radiology, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM 10, Makassar, 90245, Indonesia; Tammase, J., Department of Neurology, Faculty of Medicine, Universitas Hasanuddin, Jl. Perintis Kemerdekaan KM 10, Makassar, 90245, Indonesia; Firdaus, M., Department of Neurosurgery, Dharmais Hospital National Cancer Center, Jl. Letjen Jend. S. Parman No.84-86, Jakarta, 11420, Indonesia; Susanto, E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Prihartono, J., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia |
BACKGROUND: Histopathological examination is the gold standard for diagnosing meningioma and determining the treatments. However, it is invasive in nature. This study was conducted to identify intratumoral and peritumoral apparent diffusion coefficient (ADC) value and mRNA O6-methylguanine-DNA methyltransferase (MGMT) expression in meningioma. METHODS: Data were collected from 39 patients who were clinically diagnosed with meningioma. However, only 37 patients met the inclusion criteria. These subjects then underwent examinations and received treatment from October 2017 to September 2018. Magnetic resonance imaging (MRI) data with diffusion-weighted imaging-apparent diffusion coefficient (DWI-ADC) sequence, histopathological diagnosis of meningioma, and results of MGMT mRNA expression were obtained. RESULTS: The most frequent type of low-grade and overall tumor was meningioma not otherwise specified (56.8%). For high-grade tumor, there were two atypical cases: atypical meningioma (2.7%) and rhabdoid meningioma (2.7%). Meningothelial meningioma had the highest mean value of minimum intratumoral ADC at 864.57±219 x10-3 mm2/s, whereas rhabdoid meningioma had the lowest at 417 x10-3 mm2/s. For minimum peritumoral ADC, rhabdoid meningioma had the highest mean value at 1,651 x10-3 mm2/s, while atypical meningioma has the lowest at 1,281 x10-3 mm2/s. For MGMT mRNA, meningothelial meningioma had the highest mean value at 10±1.2 fold change, whereas rhabdoid meningioma had the lowest mean at 6.18 fold change. CONCLUSION: WHO grade I meningiomas had higher minimum intratumoral ADC values and higher MGMT mRNA expression than the high-grade tumors. Minimum peritumoral ADC values differed across the histopathological grades. © 2021. All Rights Reserved. |
ADC; meningioma; messenger; methyltransferases; MGMT mRNA; MRI; RNA; RT-PCR |
|
Prodia Education and Research Institute |
20853297 |
|
|
Article |
Q4 |
160 |
22228 |
|
|
|
714 |
S. Sitohang I.B., Legiawati L., Suseno L.S., Safira F.D. |
56734569200;57202804484;57202804092;57261863100; |
Trichloroacetic Acid Peeling for Treating Photoaging: A Systematic Review |
2021 |
Dermatology Research and Practice |
2021 |
|
3085670 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115103407&doi=10.1155%2f2021%2f3085670&partnerID=40&md5=9d2fa9a3d858b06aaf4bba3cc0802e10 |
Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
S. Sitohang, I.B., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Legiawati, L., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suseno, L.S., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Safira, F.D., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Photoaging can significantly contribute to lower quality of life. Medium-deep peeling using trichloroacetic acid allows controlled keratocoagulation through the dermis and into the dermal papillary layer that is effective for skin rejuvenation. The purpose of this article is to give updates regarding the efficacy, possible adverse events, and patient satisfaction of trichloroacetic acid (TCA) peeling for skin rejuvenation by assessing various photoaging parameters. A systematic review of prospective trial articles collected from PubMed, MEDLINE, EMBASE, Cochrane, and Scopus databases was conducted on November 2, 2020. Treatment efficacy was assessed based on the photoaging parameters used by each study. Adverse events and patient satisfaction as the secondary outcome were assessed based on patients-perceived improvements. Five studies included three randomized comparison studies and two prospective cohort studies. These studies show that TCA peeling significantly improve the cosmesis of photoaged facial skin. Low concentration is effective for superficial sun damage. Medium-depth peels using a higher concentration of TCA or as combination therapy are effective as skin resurfacing agents to reduce wrinkles. Some adverse effects may occur but usually resolve within weeks. Overall patients were satisfied with the treatment result. An equivalent basic skin preparation such as topical retinoic acid skin priming prior to intervention is necessary for more objective comparison. Further research studies with a larger sample size and longer follow-up period are required. This evidence suggests that TCA peeling is effective in photoaging treatment, either as monotherapy or as combination therapy with other modalities. © 2021 Irma Bernadette S. Sitohang et al. |
|
melanin; trichloroacetic acid; actinic keratosis; adult; bacterial superinfection; burning sensation; chemexfoliation; cohort analysis; edema; erythema; female; human; hydration status; hyperpigmentation; hypopigmentation; male; monotherapy; outcome assessment; pain; patient satisfaction; photoaging; quality of life; randomized controlled trial (topic); Review; systematic review; treatment outcome; wrinkle |
Hindawi Limited |
16876113 |
|
|
Review |
Q3 |
456 |
10893 |
|
|
|
715 |
Puspita F.M., Yunir E., Agustina P.S., Sauriasari R. |
57257264000;36520254800;57217065969;16246507200; |
Effect of angiotensin receptor blocker and angiotensin converting enzyme inhibitor on kidney function and blood potassium level in indonesian type 2 diabetes mellitus with hypertension: A three-month cohort study |
2021 |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
14 |
|
|
3841 |
3849 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114809524&doi=10.2147%2fDMSO.S310091&partnerID=40&md5=4d027eb31fcf71d05393ccf9ca3738b6 |
Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Puspita, F.M., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Agustina, P.S., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Sauriasari, R., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia |
Purpose: National formulary restrictions in Indonesia (2019) require estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m2 to be able to prescribe telmisartan and valsartan and ACE-I intolerance to be able to prescribe irbesartan and candesartan. These restrictions are based on economic considerations and differ from American Diabetes Association (ADA) (2020) guidelines which allow equal use of angiotensin II receptor blockers (ARB) and angiotensin-converting enzyme inhibitors (ACE-I) without restriction. Since there is a need to evaluate the different effects of ACE-I and ARB in the Indonesian hypertensive type 2 diabetes mellitus (T2DM) population, we compare their effects on urine albumin-to-creatinine ratio (UACR), estimated glomerular filtration rate (eGFR), and blood potassium level. Patients and Methods: A prospective cohort study at RSUPN Dr. Cipto Mangunkusumo Hospital was conducted in 123 T2DM patients. We followed the study subjects prospectively for three months using a validated questionnaire, health record, and laboratory data. Results: After 3 months of observation, there were no significant changes, except increased BMI values (p = 0.046) in the ACE-I group, and decreased LDL value (p = 0.016) and HDL value (p = 0.004) in the ARB group. Multivariate analysis showed that the consumption of ACE-I or ARB was not associated with a decrease/constant of UACR or increase potassium level, even after adjusting by confounding variables. Interestingly, we found ARB was more likely to increase eGFR, but the significance was lost once the duration of ACE-I/ARB use was entered into the model. In addition, BMI >25 kg/m2 was a significant factor associated with decreased/constant UACR, maleness was significant for increased eGFR, and declining systolic blood pressure for increase in potassium level. Conclusion: ACE-I and ARB have a similar effect on UACR and blood potassium level, but ARB slightly increased eGFR compared to ACE-I within three months of consumption. © 2021 Puspita et al. |
Angiotensin II receptor blockers; Angiotensin-converting enzyme inhibitors; Chronic kidney disease; EGFR; Type 2 diabetes mellitus; UACR |
|
Dove Medical Press Ltd |
11787007 |
|
|
Article |
Q2 |
853 |
5525 |
|
|
|
716 |
Dewi S., Sadikin M., Mulyawan W. |
57192904541;36981411100;57192910410; |
Oxidative stress in the heart of rats exposed to acute intermittent hypobaric hypoxia |
2021 |
Ukrainian Biochemical Journal |
93 |
3 |
|
68 |
74 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114748388&doi=10.15407%2fubj93.03.068&partnerID=40&md5=a11d4d4d31ac5bf34a38f63a8507d433 |
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Aerophysiology, Air Force Indonesian National Army, Lakespra Saryanto, Jakarta, Indonesia |
Dewi, S., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sadikin, M., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mulyawan, W., Department of Aerophysiology, Air Force Indonesian National Army, Lakespra Saryanto, Jakarta, Indonesia |
It is known that the altitude area causes hypoxic conditions due to the low oxygen partial pressure. This study was conducted to estimate oxidative stress indices in the heart tissue after Wister rats exposure to the acute intermittent hypobaric hypoxia. Hypobaric hypoxia exposure was simulated by keeping the rats in a hypobaric chamber for 1 min at 35,000 feet altitude. After that the altitude was gradually reduced to 30,000 and 25,000 feet and maitained for 5 min. 25 male Wistar rats were divided into control group and four treatment groups (I-IV), consisting of rats exposed 1, 2, 3 and 4 times to hypobaric hypoxia with a frequency once a week. The animals were removed from the experiment at the height of 18,000 feet and the heart tissue was obtained. The carbonyl groups and MDA levels and superoxide dismutase and catalase activity were exami-ned in the supernatant of the heart tissue homogenate. In the samples of group I, the decrease in catalase activity with a simultaneous notable increase in carbonyl groups level was observed compared to control. In the samples of groups III and IV, the carbonyl level normalized and the activity of both antioxidant enzymes increased significantly. It was concluded that the increase of antioxidant enzymes activity can contribute to cardiac tissue adaptive response to acute hypobaric hypoxia exposure. © 2021 Dewi S. et al. |
Acute intermittent hypobaric hypoxia; Antioxidant enzymes; Heart; Oxidative stress |
|
Palladin Institute of Biochemistry of the NASU |
24094943 |
|
|
Article |
Q4 |
173 |
21241 |
|
|
|
717 |
Kadharusman M.M., Antarianto R.D., Hardiany N.S. |
57222724597;57190862806;57192910605; |
A review of the impact of calorie restriction on stem cell potency |
2021 |
Malaysian Journal of Medical Sciences |
28 |
4 |
|
5 |
13 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114744628&doi=10.21315%2fmjms2021.28.4.2&partnerID=40&md5=f082ca9d61a167cf3fec646a0e6012b7 |
Undergraduate Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kadharusman, M.M., Undergraduate Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Antarianto, R.D., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hardiany, N.S., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Calorie restriction (CR) prolongs lifespan in various species and also minimises pathologies caused by aging. One of the characteristics seen in age-related pathologies is stem cell exhaustion. Here, we review the various impacts of CR on mammalian health mediated through stem cell potency in various tissues. This study comprised of a literature search through NCBI, Science Direct, Google Scholar and PubMed, focusing on the impact of CR on pluripotency. In the skeletal muscle, CR acts as an anti-inflammatory agent and increases the presence of satellite cells endogenously to improve regeneration, thus causing a metabolic shift to oxidation to meet oxygen demand. In the intestinal epithelium, CR suppresses the mechanistic target of rapamycin complex 1 (mTORC1) signalling in Paneth cells to shift the stem cell equilibrium towards self-renewal at the cost of differentiation. In haematopoiesis, CR prevents deterioration or maintains the function of haematopoietic stem cells (HSCs) depending on the genetic variation of the mice. In skin and hair follicles, CR increases the thickness of the epidermis and hair growth and improves hair retention through stem cells. CR mediates the proliferation and self-renewal of stem cells in various tissues, thus increasing its regenerative ability. © Penerbit Universiti Sains Malaysia, 2021. |
Calorie restriction; Pluripotency; Stem cell |
apoptosis; caloric restriction; cell differentiation; cell proliferation; deterioration; epidermis; fluorescence activated cell sorting; gene expression; genetic variation; hair follicle; hematopoietic stem cell; insulin sensitivity; intestine epithelium; microenvironment; nonhuman; oxidative phosphorylation; oxidative stress; oxygen consumption; physical activity; regenerative ability; Review; signal transduction; skeletal muscle; stem cell; thermal conductivity; upregulation |
Penerbit Universiti Sains Malaysia |
1394195X |
|
|
Review |
Q3 |
394 |
12287 |
|
|
|
718 |
Umiatin U., Hadisoebroto Dilogo I., Sari P., Kusuma Wijaya S. |
57202292099;57252710600;55776482300;57253327600; |
Histological Analysis of Bone Callus in Delayed Union Model Fracture Healing Stimulated with Pulsed Electromagnetic Fields (PEMF) |
2021 |
Scientifica |
2021 |
|
4791172 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114651138&doi=10.1155%2f2021%2f4791172&partnerID=40&md5=bebbcb4fbf1dcad92f29c04e06fd11bf |
Department of Physics, Faculty of Mathematics and Natural Science, State University of Jakarta, Jakarta, Indonesia; Doctoral Program in Biomedical Science, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Physics, Faculty of Mathematics and Natural Science, University of Indonesia, Depok, Indonesia |
Umiatin, U., Department of Physics, Faculty of Mathematics and Natural Science, State University of Jakarta, Jakarta, Indonesia, Doctoral Program in Biomedical Science, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Hadisoebroto Dilogo, I., Department of Orthopedic and Traumatology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sari, P., Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Kusuma Wijaya, S., Department of Physics, Faculty of Mathematics and Natural Science, University of Indonesia, Depok, Indonesia |
Delayed union and nonunion fractures are clinical challenges for orthopedic surgeons. The development of fracture complications, such as delayed union and nonunion fractures, is still difficult to predict. Various methods are being investigated to improve fracture healing and prevent complications in patients. There are various methods to promote fracture healing, broadly divided into biological, chemical, and physical methods. One of the most widely used physical methods to promote fracture healing is the pulsed electromagnetic field (PEMF). This study aimed to evaluate the healing process of delayed union fracture after being stimulated by PEMF. Twenty-four rats were randomly divided into two groups: the control group (n = 12) and the PEMF group (n = 12). Delayed union fracture was performed on the left femur of all rats. Subsequently, the PEMF group was given PEMF stimulus with a magnetic field intensity of 1.6 mT and a frequency of 50 Hz for 4 hours/day and 7 days/week. The fracture healing process was evaluated on days 5, 10, 18, and 28 based on the bone callus histology using safranin O fast green (SOFG) staining. The results of the histological analysis showed that bone cartilage was higher in the PEMF group than in the control group throughout the observation period. In addition, the PEMF group had less fibrous tissue at the beginning of the healing. This finding indicates PEMF stimulation has an effect on inducing osteogenesis on fracture healing and reducing the risk of delayed union. © 2021 U. Umiatin et al. |
|
|
Hindawi Limited |
2090908X |
|
|
Article |
Q2 |
474 |
10550 |
|
|
|
719 |
Habiburrahman M., Ariq H., Yusharyahya S.N. |
57204537114;57252668400;57211780941; |
The role of lipid and the benefit of statin in augmenting rifampicin effectivity for a better leprosy treatment |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
F |
|
246 |
259 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114611520&doi=10.3889%2foamjms.2021.6263&partnerID=40&md5=1f7a547ae466b610bf3ce7e833b58a56 |
Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
Habiburrahman, M., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Ariq, H., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Yusharyahya, S.N., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
BACKGROUND: Although leprosy remains as a serious disease of the skin and nervous system, the current treatment is still lacking in its effectiveness. AIM: This literature review will explore the association of lipid and leprosy, as well as the potential of statin and other lipid-lowering agents as adjunctive drugs to combat leprosy. MATERIALS AND METHODS: Articles were searched through the PubMed, EBSCOhost, and Google Scholar with the keywords: immunomodulation, lipid-body, lipids, leprosy, Mycobacterium leprae, pathogenesis, rifampin or rifampicin, and statins. A manual searching is also carried out to find an additional relevant information to make this literature review more comprehensive. RESULTS: The literatures showed that lipids are highly correlated with leprosy through alterations in serum lipid profile, metabolism, pathogenesis, and producing oxidative stress. Statins can diminish lipid utilization in the pathogenesis of leprosy and show a mycobactericidal effect by increasing the effectiveness of rifampicin and recover the function of macrophages. In addition, Statins have anti-inflammatory properties which may aid in preventing type I and II reactions in leprosy. Standard multidrug therapy might reduce the efficacy of statins, but the effect is not clinically significant. The statin dose-response curve also allows therapeutic response to be achieved with minimal dose. CONCLUSION: The various pleiotropic effects of statins make it a potential adjunct to standard treatment for leprosy in the future. © 2021 Muhammad Habiburrahman, Haekal Ariq, Shannaz Nadia Yusharyahya. |
Anti-inflammatory; Bactericidal; Leprosy; Lipids; Rifampicin; Statins |
hydroxymethylglutaryl coenzyme A reductase inhibitor; interleukin 10; mevalonic acid; rifampicin; Article; human; immunomodulation; inflammation; lepromatous leprosy; leprosy; lipid metabolism; macrophage; macrophage function; Mycobacterium leprae; oxidative stress; phagocytosis; physiological stress; pleiotropy; polypharmacy; sensitivity and specificity; systematic review; treatment response; tuberculoid leprosy |
Scientific Foundation SPIROSKI |
18579655 |
|
|
Article |
Q3 |
288 |
15252 |
|
|
|
720 |
Hariyanto A.D., Permata T.B.M., Gondhowiardjo S.A. |
57253039400;57197808751;6508327402; |
Role of CD4+CD25+FOXP3+ TReg cells on tumor immunity |
2021 |
Immunological Medicine |
|
|
|
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114605951&doi=10.1080%2f25785826.2021.1975228&partnerID=40&md5=dee345614c66584e8dcc9d94211b7f1f |
Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Hariyanto, A.D., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Permata, T.B.M., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Gondhowiardjo, S.A., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Not all T cells are effector cells of the anti-tumor immune system. One of the subpopulations of CD4+ T cells that express CD25+ and the transcription factor FOXP3, known as Regulator T cells (TReg), plays an essential role in maintaining tolerance and immune homeostasis preventing autoimmune diseases, minimalize chronic inflammatory diseases by enlisting various immunoregulatory mechanisms. The balance between effector T cells (Teff) and regulator T cells is crucial in determining the outcome of an immune response. Regarding tumors, activation or expansion of TReg cells reduces anti-tumor immunity. TReg cells inhibit the activation of CD4+ and CD8+ T cells and suppress anti-tumor activity in the tumor microenvironment. In addition, TReg cells also promote tumor angiogenesis both directly and indirectly to ensure oxygen and nutrient transport to the tumor. There is accumulating evidence showing a positive result that removing or suppressing TReg cells increases anti-tumor immune response. However, depletion of TReg cells will cause autoimmunity. One strategy to improve or restore tumor immunity is targeted therapy on the dominant effector TReg cells in tumor tissue. Various molecules such as CTLA-4, CD4, CD25, GITR, PD-1, OX40, ICOS are in clinical trials to assess their role in attenuating TReg cells’ function. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the Japanese Society of Clinical Immunology. |
anti-tumor immunity; immunotherapy; regulatory T cells; TReg; TReg-targeting therapy |
|
Taylor and Francis Ltd. |
25785826 |
|
|
Review |
Q3 |
419 |
11666 |
|
|
