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761 |
Lesmana C.R.A., Paramitha M.S., Gani R.A. |
8977683000;57212562901;23495930300; |
The Role of Interventional Endoscopic Ultrasound in Liver Diseases: What Have We Learnt? |
2021 |
Canadian Journal of Gastroenterology and Hepatology |
2021 |
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9948979 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110213187&doi=10.1155%2f2021%2f9948979&partnerID=40&md5=a038d06d78df9e699aa4a27ead88d0bb |
Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia; Digestive Disease and GI Oncology Center, Medistra Hospital, Jakarta, Indonesia |
Lesmana, C.R.A., Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia, Digestive Disease and GI Oncology Center, Medistra Hospital, Jakarta, Indonesia; Paramitha, M.S., Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia; Gani, R.A., Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Chronic liver disease (CLD) is still a major problem, where the disease progression will lead to liver cirrhosis (LC) or hepatocellular carcinoma (HCC). Portal hypertension (PH) management and loco-regional therapy for HCC have become the cornerstones in advanced liver disease management. Recently, there are studies looking at the potential role of interventional endoscopic ultrasound (EUS) in liver diseases. EUS may be useful in vascular changes of the digestive wall evaluation, performing dynamic assessment of hemodynamic changes, predicting variceal bleeding and rebleeding risk, and assessing the pharmacological effects. In PH management, EUS-guided vascular therapy - which revolves around glue injection, endovascular coil placement/embolization, and combination of both - has shown promising results. As a diagnostic modality for liver cancer, the implementation of EUS in liver diseases is currently not only limited to liver biopsy (EUS-LB) but also in shear-wave elastography (SWE) and portal pressure gradient measurement, as well as portal vein sampling. The application of EUS-guided radiofrequency ablation (EUS-RFA) and tumor injection can also overcome the limitations shown by both modalities without EUS. Nevertheless, establishing EUS as a firm diagnostic and therapeutic modality is still challenging since the performance of interventional EUS requires high expertise and adequate facilities. © 2021 Cosmas Rinaldi A. Lesmana et al. |
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azygos vein; brachytherapy; chronic liver disease; contrast-enhanced ultrasound; cryotherapy; Doppler flowmetry; elastography; endoscopic ultrasonography; gastrointestinal hemorrhage; human; liver abscess; liver biopsy; liver cirrhosis; liver injury; liver metastasis; nonhuman; paracentesis; peritonitis; portal vein blood pressure; predictive value; radiation exposure; regional perfusion; Review; risk assessment; sclerotherapy; sensitivity and specificity; shear wave elastography; splanchnic blood flow; diagnostic imaging; endoscopic ultrasonography; esophagus varices; interventional ultrasonography; liver cell carcinoma; liver tumor; tumor recurrence; Carcinoma, Hepatocellular; Endosonography; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Liver Neoplasms; Neoplasm R |
Hindawi Limited |
22912789 |
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34258255 |
Review |
Q2 |
921 |
4950 |
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762 |
Gunarti D.R., Sukmawati D., Nasser M.K., Ikram T.A.Z., Pribawa R.N., Suryandari D.A. |
57196435346;55615650900;57225994342;57225992297;57225996674;6505763338; |
Rice bran supplement enhances gsh levels in testis and liver of carbon tetrachloride-induced rats [Pirinç kepeği takviyesi, karbon tetraklorürle İndüklenen sıçanların testis ve karaciğerinde gsh seviyelerini artırır] |
2021 |
Fabad Journal of Pharmaceutical Sciences |
46 |
2 |
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129 |
138 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110108277&partnerID=40&md5=dcb45fa417f0982414baa1197be3c11f |
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Gunarti, D.R., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sukmawati, D., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nasser, M.K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ikram, T.A.Z., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pribawa, R.N., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Suryandari, D.A., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
In the present study, the potency of rice bran as an antioxidant was examined. Rice bran is a by-product of the rice milling process, despite being a rich nutrient, it has limitations in food application. In this study, we used carbon tetrachloride-induced rats (CCl4) as a model of oxidative stress and examined the effect of extract IPB 3S rice bran supplement (RBS) on testis and liver endogenous antioxidant. The testis and liver were used as the representative organs which prone to exposure to reactive oxygen species (ROS). We used 150 and 300 mg.kg-1 Body weight (BW) of RBS. The Concentration of glutathione (GSH) in both organs was measured. All groups administered by RBS had significantly higher GSH levels compared to the CCl4 group, both in testis and liver. The dose of 300 mg.kg-1 BW RBS had a significantly higher GSH level in testis, while 150 mg.kg-1 VA RBS had a significantly higher GSH level in the liver tissue compared to the control group accordingly. Thus, the rice bran supplement enhances GSH levels in rat’s liver and testis which potentially has protective effects. © 2021 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved. |
Antioxidants; CCl4; Glutathione; IPB 3S; Liver; Rice bran; Testis |
antioxidant; carbon tetrachloride; glutathione; plant extract; reactive oxygen metabolite; rice bran extract; unclassified drug; animal experiment; animal model; animal tissue; Article; body weight; cell protection; comparative study; controlled study; diet supplementation; drug effect; drug potency; liver tissue; male; nonhuman; oxidative stress; rat; rice bran; testis |
Society of Pharmaceutical Sciences of Ankara (FABAD) |
13004182 |
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Article |
Q3 |
150 |
23158 |
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763 |
Gunardi W.D., Timotius K.H., Natasha A., Evriarti P.R. |
57222314683;24299781600;57211428938;57226004232; |
Biofilm targeting strategy in the eradication of burkholderia infections: A mini-review |
2021 |
Open Microbiology Journal |
15 |
1 |
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51 |
57 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110074931&doi=10.2174%2f1874285802115010051&partnerID=40&md5=70632c812ea82598129daf4afdd465df |
Department of Microbiology, Faculty of Medicine, Krida Wacana Christian University (UKRIDA), Jakarta, Indonesia; Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Microbiolgy, Health Labortory of Makassar (BBLK Makassar), Makassar, Indonesia |
Gunardi, W.D., Department of Microbiology, Faculty of Medicine, Krida Wacana Christian University (UKRIDA), Jakarta, Indonesia; Timotius, K.H., Department of Microbiology, Faculty of Medicine, Krida Wacana Christian University (UKRIDA), Jakarta, Indonesia; Natasha, A., Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Evriarti, P.R., Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Microbiolgy, Health Labortory of Makassar (BBLK Makassar), Makassar, Indonesia |
Burkholderia are intracellular pathogenic bacteria which can produce biofilm. This biofilm protects the intracellular pathogenic bacteria from antibiotic treatment and the immunological system of the host. Therefore, this review aims to describe the capacity of Burkholderia to form a biofilm, the regulation of its biofilm formation, the efficacy of antibiotics to eradicate biofilm, and the novel therapy which targets its biofilm. Burkholderia's biofilm is characterized by its lipopolysaccharides, exopolysaccharides (EPSs), biofilm-associated proteins, and eDNA. Its regulation is made by quorum sensing, c-di-AMP, sRNA, and two component systems. Many antibiotics have been used as sole or mixture agents; however, they are not always effective in eradicating the biofilm-forming Burkholderia. Inhibitors of quorum sensing and other non-conventional antibiotic approaches are promising to discover effective treatment of Burkholderia infections. © 2021, Bentham Science Publishers. All rights reserved. |
Antibiotic; Biofilm; Burkholderia; Exopolysaccharide; Lipid A; Quorum sensing |
acetazolamide; amoxicillin; antibiotic agent; cefepime; ceftazidime; colistin; echinocandin; exopolysaccharide; gentamicin; imipenem; indisulam; lipopolysaccharide; macrolide; meropenem; piperacillin plus tazobactam; polymyxin B; RANTES; saccharin; sulpiride; tobramycin; topiramate; transcriptome; vancomycin; virulence factor; Acinetobacter baumannii; antibiofilm activity; antibiotic resistance; antibiotic sensitivity; antibiotic therapy; apoptosis; Article; autolysis; bacteremia; bacterial arthritis; bacterial colonization; bacterial gene; bacterial growth; bacterial virulence; Betaproteobacteria; biofilm; Burkholderia cenocepacia; Burkholderia infection; Burkholderia pseudomallei; cell aggregation; DNA damage; Enterococcus faecalis; extracellular matrix; gene; gene expression; Helicobact |
Bentham Science Publishers |
18742858 |
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Article |
Q3 |
502 |
10043 |
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764 |
Yulia D.E., Kurnia K.H., Mahyuddin M., Edwar L., Amanda L. |
57225947931;57222405280;57225946039;55695047800;57225929959; |
Successful Management of a Rare Paediatric Orbital Subperiosteal Abscess: A Case Report |
2021 |
African Vision and Eye Health |
80 |
1 |
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1 |
3 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109939244&doi=10.4102%2fAVEH.V80I1.631&partnerID=40&md5=ad4fc29a3f5162b1ce2a0a28e7eafe79 |
Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Yulia, D.E., Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Kurnia, K.H., Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Mahyuddin, M., Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Edwar, L., Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Amanda, L., Department of Ophthalmology, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Paediatric orbital subperiosteal abscess (SPA) requires prompt and appropriate treatment to prevent further complication. A 10-year-old girl with a history of sinusitis came with progressive swelling on her left eye, non-axial proptosis and visual acuity (VA) was 2/60. A computed tomography scan revealed a SPA formation in the superior left orbit. This report highlights that intravenous antibiotic with incision and drainage surgery improved the VA with resolution of proptosis and swelling. © 2021. The Author(s). Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License. |
antibiotic administration; incision and drainage; non-axial proptosis; orbital infection; paediatric subperiosteal abscess |
amoxicillin; antibiotic agent; ceftriaxone; methylprednisolone; metronidazole; Article; case report; child; clinical article; computer assisted tomography; endoscopic sinus surgery; exophthalmos; eye pain; eye swelling; female; follow up; human; intraocular pressure; orbit infection; orbital subperiosteal abscess; visual acuity |
AOSIS (pty) Ltd |
24133183 |
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Article |
Q4 |
186 |
20274 |
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765 |
Tan J.W.C., Chew D.P., Brieger D., Eikelboom J., Montalescot G., Ako J., Kim B.-K., Quek D.K.L., Aitken S.J., Chow C.K., Chour S., Tse H.F., Kaul U., Firdaus I., Kubo T., Liew B.W., Chong T.T., Sin K.Y.K., Yeh H.-I., Buddhari W., Chunhamaneewat N., Hasan F., Fox K.A.A., Nguyen Q.N., Lo S.T.H. |
14829599000;7102026332;7004107910;7006303000;7102302494;6701389098;35189204900;57213290935;57225921713;8871779800;57225956090;7006070805;7102340294;55796864700;57226325834;57205155828;36609879000;57223949258;57225966367;57192991797;6505509528;57225971750;57224650893;39962151600;7401542169; |
2020 Asian Pacific Society of Cardiology Consensus Recommendations on Antithrombotic Management for High-risk Chronic Coronary Syndrome |
2021 |
European Cardiology Review |
16 |
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e26 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109820982&doi=10.15420%2fECR.2020.45&partnerID=40&md5=349f92694e4c018a59343a627d38ced6 |
National Heart Centre, Singapore, Singapore; Sengkang General Hospital, Singapore, Singapore; College of Medicine and Public Health, Flinders University, Adelaide, Australia; Concord Repatriation General Hospital, University of Sydney, Sydney, Australia; McMaster UniversityON, Canada; Sorbonne University, Paris, France; ACTION Study Group, France; Pitié-Salpêtrière University Hospital (AP-HP), Paris, France; Kitasato University and Hospital, Kanagawa, Japan; Yonsei University College of Medicine, South Korea; Pantai Hospital Kuala Lumpur, Kuala Lumpur, Malaysia; University of Sydney, Sydney, Australia; Westmead Applied Research Centre, University of Sydney, Sydney, Australia; Westmead Hospital, Sydney, Australia; Calmette Hospital, Phnom Penh, Cambodia; Queen Mary Hospital, University of Hong Kong, Hong Kong; Batra Hospital and Medical Research Center, New Delhi, India; Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Wakayama Medical University, Wakayama, Japan; Changi General Hospital, Singapore, Singapore; Singapore General Hospital, Singapore, Singapore; MacKay Memorial Hospital, MacKay Medical College, Taipei, Taiwan; King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Siriraj Hospital, Mahidol University, Bangkok, Thailand; Heart & Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates; University of Edinburgh, Edinburgh, United Kingdom; Hanoi Medical University, Vietnam National Heart Institute, Hanoi, Viet Nam; Liverpool Hospital, Sydney, Australia |
Tan, J.W.C., National Heart Centre, Singapore, Singapore, Sengkang General Hospital, Singapore, Singapore; Chew, D.P., College of Medicine and Public Health, Flinders University, Adelaide, Australia; Brieger, D., Concord Repatriation General Hospital, University of Sydney, Sydney, Australia; Eikelboom, J., McMaster UniversityON, Canada; Montalescot, G., Sorbonne University, Paris, France, ACTION Study Group, France, Pitié-Salpêtrière University Hospital (AP-HP), Paris, France; Ako, J., Kitasato University and Hospital, Kanagawa, Japan; Kim, B.-K., Yonsei University College of Medicine, South Korea; Quek, D.K.L., Pantai Hospital Kuala Lumpur, Kuala Lumpur, Malaysia; Aitken, S.J., University of Sydney, Sydney, Australia; Chow, C.K., Westmead Applied Research Centre, University of Sydney, Sydney, Australia, Westmead Hospital, Sydney, Australia; Chour, S., Calmette Hospital, Phnom Penh, Cambodia; Tse, H.F., Queen Mary Hospital, University of Hong Kong, Hong Kong; Kaul, U., Batra Hospital and Medical Research Center, New Delhi, India; Firdaus, I., Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Kubo, T., Wakayama Medical University, Wakayama, Japan; Liew, B.W., Changi General Hospital, Singapore, Singapore; Chong, T.T., Singapore General Hospital, Singapore, Singapore; Sin, K.Y.K., National Heart Centre, Singapore, Singapore; Yeh, H.-I., MacKay Memorial Hospital, MacKay Medical College, Taipei, Taiwan; Buddhari, W., King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Chunhamaneewat, N., Siriraj Hospital, Mahidol University, Bangkok, Thailand; Hasan, F., Heart & Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates; Fox, K.A.A., University of Edinburgh, Edinburgh, United Kingdom; Nguyen, Q.N., Hanoi Medical University, Vietnam National Heart Institute, Hanoi, Viet Nam; Lo, S.T.H., Liverpool Hospital, Sydney, Australia |
The unique characteristics of patients with chronic coronary syndrome (CCS) in the Asia-Pacific region, heterogeneous approaches because of differences in accesses and resources and low number of patients from the Asia-Pacific region in pivotal studies, mean that international guidelines cannot be routinely applied to these populations. The Asian Pacific Society of Cardiology developed these consensus recommendations to summarise current evidence on the management of CCS and provide recommendations to assist clinicians treat patients from the region. The consensus recommendations were developed by an expert consensus panel who reviewed and appraised the available literature, with focus on data from patients in Asia-Pacific. Consensus statements were developed then put to an online vote. The resulting recommendations provide guidance on the assessment and management of bleeding and ischaemic risks in Asian CCS patients. Furthermore, the selection of long-term antithrombotic therapy is discussed, including the role of single antiplatelet therapy, dual antiplatelet therapy and dual pathway inhibition therapy. © 2021 Radcliffe Group Ltd. All rights reserved. |
Anticoagulant; Antiplatelet; Asia-Pacific; Bleeding; Chronic coronary syndrome; Consensus; Ischaemia |
acetylsalicylic acid; anticoagulant agent; clopidogrel; prasugrel; ticagrelor; age; anticoagulant therapy; Article; Asia; bleeding risk score; brain hemorrhage; cardiac patient; consensus; coronary artery disease; dual antiplatelet therapy; gastrointestinal hemorrhage; heart muscle ischemia; high risk patient; human; percutaneous coronary intervention; thrombosis |
Radcliffe Medical Media |
17583756 |
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Article |
Q2 |
864 |
5422 |
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766 |
Dharma S., Dakota I., Andriantoro H., Firdaus I., Gunawan Limadhy I., Van De Werf F. |
55101301700;55796663700;55037171500;55796864700;57225219360;36048879600; |
Trends in reperfusion therapy for acute ST-segment elevation myocardial infarction in an academic percutaneous coronary intervention center in the metropolitan area of a developing country: Insights from the Jakarta Acute Coronary Syndrome registry |
2021 |
Coronary Artery Disease |
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466 |
467 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109587625&doi=10.1097%2fMCA.0000000000000939&partnerID=40&md5=a4f6e1151d84a687c4d99a6b1f8480c6 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Indonesia; Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium |
Dharma, S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Dakota, I., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Indonesia; Andriantoro, H., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Indonesia; Firdaus, I., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Indonesia; Gunawan Limadhy, I., Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Van De Werf, F., Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium |
[No abstract available] |
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adverse event; causality; epidemiology; female; fibrinolytic therapy; heart muscle reperfusion; hospital mortality; human; Indonesia; male; middle aged; mortality; organization and management; percutaneous coronary intervention; preventive health service; procedures; register; ST segment elevation myocardial infarction; time to treatment; total quality management; Causality; Female; Hospital Mortality; Humans; Indonesia; Male; Middle Aged; Myocardial Reperfusion; Percutaneous Coronary Intervention; Preventive Health Services; Quality Improvement; Registries; ST Elevation Myocardial Infarction; Thrombolytic Therapy; Time-to-Treatment |
Lippincott Williams and Wilkins |
09546928 |
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32804781 |
Article |
Q3 |
504 |
10001 |
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767 |
Bachtiar E.W., Bachtiar B.M., Theodorea C.F., Tahapary D.L., Astrella C., Natalina N. |
6507328763;15831189400;57190048861;55944492500;57210793320;57225210620; |
A pilot study of red complex and three genera subgingival microbiome in periodontitis subjects with and without diabetes, evaluated by MinION platform |
2021 |
F1000Research |
10 |
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79 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109577307&doi=10.12688%2ff1000research.28216.3&partnerID=40&md5=83c85f319460a8e5631506acfe142095 |
Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia |
Bachtiar, E.W., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Bachtiar, B.M., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Theodorea, C.F., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Tahapary, D.L., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Astrella, C., Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Natalina, N., Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia |
Background: Subgingival niche is one biofilm habitat containing rich microbiota, which plays an active role in maintaining the health of periodontal tissue and determining host response. As such, a study of changing subgingival biofilms is important for understanding the effect of a systemic condition. In this study, we compared the occurrence of six bacteria cohabiting in the subgingival area of periodontitis subjects, with (DP, n = 8) and without (NDP, n = 4) diabetes. Methods: The six genus and species of targeted bacteria were confirmed by 16S rRNA amplicon sequencing on MinION nanopore platform. Descriptive statistic was used to describe the obtained data. Results: We found that the six genus and species of targeted bacteria were detected but in different quantities in either group's periodontal pocket. Our data showed that Tannerella forsythia was the most abundant species in subgingival biofilms of the DP group of the red complex bacteria. In contrast, Aggregatibacter sp., which belongs to the phylum of proteobacteria, was present at a relatively lower level. In contrast, Fusobacterium sp., which belongs to orange complex bacteria, showed relative similarities in subgingival biofilms of both groups tested, while Veillonella sp., were abundant in the DP groups. Conclusions: Our data show that the diversity of classic periodontopathogens increased in the subgingival niche of periodontitis subjects with diabetes. It is the first study in Indonesia to apply MinION-based, full-length 16S rRNA amplicon sequencing in periodontitis patients with and without diabetes. © 2021 Bachtiar BM et al. |
16S rRNA; Diabetes; MinION; Periodontitis; Red Complex bacteria; Subgingival Microbiome |
RNA 16S; diabetes mellitus; genetics; gingiva; human; Indonesia; microflora; periodontitis; pilot study; Diabetes Mellitus; Gingiva; Humans; Indonesia; Microbiota; Periodontitis; Pilot Projects; RNA, Ribosomal, 16S |
F1000 Research Ltd |
20461402 |
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34249333 |
Article |
Q1 |
1099 |
3793 |
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768 |
Midoen Y.H., Suryandari D.A., Yunaini L., Susworo R., Auerkari E.I., Freisleben H.-J. |
57197805109;6505763338;57192911515;8438653400;10139113000;7003437337; |
Epstein-Barr virus nuclear antigen-1 is useful as therapeutic efficacy marker in serum but not in saliva of nasopharyngeal cancer patients who underwent radiotherapy |
2021 |
ecancermedicalscience |
15 |
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1254 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109546581&doi=10.3332%2fECANCER.2021.1254&partnerID=40&md5=debd5ca3a84a84eabb9d16f1bf92fc2d |
Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia; Department of Radiotherapy, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jalan Pangeran Diponegoro 71, Jakarta, 10430, Indonesia; Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jalan Salemba Raya 4, Jakarta, 10430, Indonesia; Medical Research Unit, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 4, Jakarta, 10430, Indonesia |
Midoen, Y.H., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia; Suryandari, D.A., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia; Yunaini, L., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia; Susworo, R., Department of Radiotherapy, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jalan Pangeran Diponegoro 71, Jakarta, 10430, Indonesia; Auerkari, E.I., Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jalan Salemba Raya 4, Jakarta, 10430, Indonesia; Freisleben, H.-J., Medical Research Unit, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 4, Jakarta, 10430, Indonesia |
Introduction: Nasopharyngeal carcinoma (NPC) is a multifactorial disease with genetic, viral, environmental and lifestyle-related risk factors. Epstein-Barr virus (EBV) can promote the oncogenic transformation of an infected cell into malignant. EBV encodes many stimulating products including Epstein-Barr virus nuclear antigen-1 (EBNA-1) which plays a key role in the regulation of gene expression and replication of the genome in the latent period of infection. EBNA-1 in serum and tumour tissue of NPC patients correlates with NPC prognosis. Moreover, the presence of EBV DNA in serum samples from NPC patients' blood circulation can be used as an early marker in the diagnosis of NPC. Objective: The objective of this study was to find effective methods for monitoring the progress of NPC patients undergoing radiotherapy and therapeutic efficacy by observing the changes in EBV DNA in serum and saliva. Methodology: The pre-experimental design compared blood and saliva taken from a pretest and post-test group of NPC patients before and after radiation therapy. The concentration of EBV DNA was measured in the serum and saliva after amplification using quantitative polymerase chain reaction (qPCR) with compatible primers for the EBNA-1 gene. The data were statistically analysed by paired T-test. Results: Highly significant (p = 0.0001) increase in cycle threshold qPCR and decrease in the mean concentration of EBV DNA (p = 0.0001) were observed in serum samples, but no significant changes were observed in saliva. Conclusions: The results suggest that EBV DNA in serum can be used as the gold standard and a marker for monitoring the response to radiation therapy in NPC patients, whereas the examination of EBV DNA from saliva samples is not accurate and thus, not appropriate. © 2021 ecancer Global Foundation. All rights reserved. |
CT; EBNA-1; EBV DNA; NPC; QPCR |
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ecancer Global Foundation |
17546605 |
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Article |
Q3 |
708 |
7022 |
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769 |
Birowo P., Tendi W., Rasyid N., Turek P.J., Sini I.R., Rizal M. |
6504153311;57208641745;56245069300;7006101528;56013404300;57225198196; |
Successful targeted testicular sperm extraction using microsurgical technique (microtese) following fine needle aspiration (FNA) mapping in a non-obstructive azoospermia (NOA) patient: A case report |
2021 |
Journal of Reproduction and Infertility |
22 |
1 |
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65 |
69 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109425367&doi=10.18502%2fjri.v22i1.4997&partnerID=40&md5=fa081e0db7b5deb36d248beb2dcda6dd |
Department of Urology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Indonesian Reproductive Science Institute, Bunda General Hospital, Jakarta, Indonesia; Turek Clinic, San Francisco, United States |
Birowo, P., Department of Urology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Indonesian Reproductive Science Institute, Bunda General Hospital, Jakarta, Indonesia; Tendi, W., Department of Urology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Indonesian Reproductive Science Institute, Bunda General Hospital, Jakarta, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Turek, P.J., Turek Clinic, San Francisco, United States; Sini, I.R., Indonesian Reproductive Science Institute, Bunda General Hospital, Jakarta, Indonesia; Rizal, M., Indonesian Reproductive Science Institute, Bunda General Hospital, Jakarta, Indonesia |
Background: Management for male infertility can be difficult for some cases. Surgical intervention has long been thought as the last resort to help married couples to conceive. The current guideline recommends testicular sperm extraction with microsurgery technique (microTESE) in severe cases of male infertility. However, the success rate still varies. Thus, a new strategy was needed to further increase the sperm retrieval success rate. Case Presentation: A 39-year-old male with a history of failed sperm extraction, non-obstructive azoospermia (NOA) and Y-chromosomal microdeletion came to the fertility center to undergo sperm retrieval. Fine needle aspiration (FNA) Mapping was performed prior to microTESE to increase the accuracy of sperm retrieval. After further examination with laser assisted immotile sperm selection (LAISS), five spermatozoa were found. Conclusion: The combination of FNA Mapping and microTESE increases the chance of a successful sperm extraction. © 2021 Avicenna Research Institute. All rights reserved. |
Fna mapping; Laiss; Microtese; Noa; Y-chromosomal microdeletion |
chorionic gonadotropin; clomifene citrate; follitropin; ovutrig; testosterone; adult; Article; azoospermia; case report; chromosome deletion; clinical article; clinical effectiveness; echography; fine needle aspiration biopsy; fine needle aspiration mapping; human; human tissue; intracytoplasmic sperm injection; laser assisted immotile sperm selection; male; male infertility; microsurgical epididymal sperm aspiration; microsurgical testicular sperm extraction; percutaneous epididymal sperm aspiration; physical examination; pronucleus; sperm retrieval; spermatid; spermatocyte; spermatozoon; testicular sperm extraction; testis biopsy; testis size; varicocele; Y chromosome |
Avicenna Research Institute |
22285482 |
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Article |
Q3 |
495 |
10168 |
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770 |
Saroyo Y.B., Wibowo N., Irwinda R., Prijanti A.R., Yunihastuti E., Bardosono S., Krisnadi S.R., Permata P.I., Wijaya S., Santawi V.P.A. |
57164888400;15049026900;57190855256;57190863386;57221273925;21933841000;56660648900;57225151181;56685332700;57192917419; |
Oxidative Stress Induced Damage and Early Senescence in Preterm Placenta |
2021 |
Journal of Pregnancy |
2021 |
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9923761 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109338598&doi=10.1155%2f2021%2f9923761&partnerID=40&md5=f6580c90345ba249ad3c787766d49062 |
Maternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Division of Allergy Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Department of Clinical Nutrition, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia |
Saroyo, Y.B., Maternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Wibowo, N., Maternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Irwinda, R., Maternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Prijanti, A.R., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Yunihastuti, E., Division of Allergy Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Bardosono, S., Department of Clinical Nutrition, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Krisnadi, S.R., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Indonesia; Permata, P.I., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia; Wijaya, S., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia; Santawi, V.P.A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia |
Introduction. Senescent cells have been demonstrated to release High Mobility Group Box 1 (HMGB1) which induces labor through an inflammatory pathway. This research is aimed at demonstrating whether telomere shortening, proinflammatory HMGB1, and oxidative damage marker 8-OHdG play a role in the placenta of preterm birth in comparison to term birth. Method. A cross-sectional study on 67 full thickness of the placenta obtained from mothers with term and preterm birth. Mothers with clinical signs of infection (fever>38°C, leukocytosis>18000/μL, or abnormal vaginal discharge) and other pregnancy complications were excluded. Real-time polymerase chain reaction was performed to measure T/S ratio and ELISA quantification to measure the amount of HMGB1 and 8-OHdG. Result. A total of 34 placentas from preterm and 33 placentas from term birth were examined. Maternal characteristics were comparable between the two groups. There were no statistical difference of T/S ratio (p=0.181), HMGB1 (p=0.119), and 8-OHdG (p=0.144) between the preterm and term groups. HMGB1 was moderately correlated with 8-OHdG (r=0.314). Telomere T/S ratio of the placenta did not differ between preterm and term labor despite difference in gestational age, suggesting earlier shortening in the preterm group. It is possible that critical telomere length has been achieved in both term and preterm placenta that warrants labor through senescence process. The result of our study also showed that HMGB1 was not correlated to telomere length, due to the fact that HMGB1 is not upregulated until the critical length of telomere for senescence is exhibited. Conclusion. Similar telomere length might be exhibited due to early telomere shortening in preterm birth that mimics the term placenta. The relationship between placental telomere shortening and HMGB1 release remains to be uncovered. Further research is needed to discover the factors leading to early telomere shortening in the placenta of preterm birth. © 2021 Yudianto Budi Saroyo et al. |
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cross-sectional study; female; human; metabolism; newborn; oxidative stress; placenta; pregnancy; prematurity; telomere shortening; Cross-Sectional Studies; Female; Humans; Infant, Newborn; Oxidative Stress; Placenta; Pregnancy; Premature Birth; Telomere Shortening |
Hindawi Limited |
20902727 |
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34258068 |
Article |
Q2 |
828 |
5768 |
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