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771 |
Victor A.A., Violetta L., Kusumowidagdo G., Pranata R. |
57191055282;57216555090;57200641034;57201973901; |
Pars-plana vitrectomy combined with retinectomy in severe open-globe injuries: A systematic review and meta-analysis |
2021 |
European Journal of Ophthalmology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109102924&doi=10.1177%2f11206721211029472&partnerID=40&md5=864797e21da1505f0aa16812f4da115e |
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Zhejiang University School of Medicine, Hangzhou, China; Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia |
Victor, A.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Violetta, L., Zhejiang University School of Medicine, Hangzhou, China, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia; Kusumowidagdo, G., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia |
Background: This review summarized prophylactic retinectomy technique and its effect on anatomic and functional outcomes in severe open globe injuries (OGIs). Methods: A comprehensive search in PubMed (MEDLINE), Embase, Scopus, and EuropePMC databases was performed up until 8 January 2020. Enrolled studies include case series, studies involving pars plana vitrectomy (PPV) combined with retinectomy in severe penetrating injuries with or without IOFB, perforating injuries, and globe ruptures. Primary outcome was best-corrected visual acuity (BCVA) ⩾20/200 at the end of the study. Secondary outcomes were the rate of proliferative retinopathy (PVR), globe survival rate and retinal reattachment rate. Results: A total of seven studies, involving 275 eyes with severe OGIs, is included in this study. Meta-analysis indicates that final BCVA ⩾20/200 was achieved in 61% (95% CI 49%–73%). Meta-regression analysis showed that improvement was inversely affected by the presence of pre-operative direct macular injury (p = 0.001) and corneal scar (p = 0.015). The proportion of pre-operative BCVA <20/200 was statistically insignificant to the final BCVA ⩾20/200 (p = 0.569). One study showed that the rate is higher in the retinectomy group than the non-retinectomy group (54% vs 11%). Meta-analysis showed that anatomical success can be achieved in 85% (95% CI 78%–91%) of the patients. Meta-regression analysis indicates that the anatomical success did not vary with age (p = 0.653), retinal detachment (p = 0.525), corneal scar (p = 0.596), and lens involvement (p = 0.450). Conclusion: Early PPV combined with retinectomy was associated with acceptable visual improvement and anatomical success. © The Author(s) 2021. |
eye injuries; open-globe injuries; proliferative vitreoretinopathy; Retinectomy; vitrectomy |
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SAGE Publications Ltd |
11206721 |
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Article |
Q2 |
790 |
6120 |
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772 |
Maryam R.S., Sahar J., Hastono S.P., Harimurti K. |
57209730009;6508226729;57211434645;23473513200; |
Common symptoms of alzheimer’s dementia that are easily recognizable by families [Sintomas comuns da demência de alzheimer facilmente reconhecíveis pelas famílias] |
2021 |
Dementia e Neuropsychologia |
15 |
2 |
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186 |
191 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109080999&doi=10.1590%2f1980-57642021dn15-020005&partnerID=40&md5=7d8636011b9ebdb60c6dd608e999cc16 |
Faculty of Nursing, Universitas Indonesia, Jawa Barat, Indonesia; Faculty of Medicine, Universitas Indonesia, Jawa Barat, Indonesia; Faculty of Public Health, Universitas Indonesia, Jawa Barat, Indonesia |
Maryam, R.S., Faculty of Nursing, Universitas Indonesia, Jawa Barat, Indonesia; Sahar, J., Faculty of Nursing, Universitas Indonesia, Jawa Barat, Indonesia; Hastono, S.P., Faculty of Medicine, Universitas Indonesia, Jawa Barat, Indonesia; Harimurti, K., Faculty of Public Health, Universitas Indonesia, Jawa Barat, Indonesia |
The increase in dementia incidence among the elderly is directly related to aging, which is associated with changes in bodily functions and other health-related risk factors. Alzheimer’s dementia is the most prevalent form of dementia, and individuals in the late stages are predominantly dependent on other family members. Therefore, it is important for families, as the closest support group, to recognize common symptoms early. Objective: To provide a family-friendly guide to the ten common symptoms of Alzheimer’s dementia. Methods: This is a descriptive survey-based research that included 354 families comprising elderly people (≥60 years) residing in Jakarta. The instrument aimed at identifying ten common Alzheimer’s dementia symptoms in Indonesia. Descriptive statistical analysis based on frequency tables was used. Results: The participant’s major characteristics were age ≥66 years (52.3%), female sex (70.3%) and primary school education (87.3%). The predominant symptoms experienced by 42.4% of the elderly included forgetting recent events and asking questions and narrating a particular detail repeatedly. The remaining 35.6% demonstrated signs of forgetting where an item was placed and frequently suspecting others of theft and concealment of personal items. Conclusion: The symptoms of frequently forgetting new events and the location of personal belongings are of particular concern for families, as they have a propensity to progress and interfere with daily activities. Therefore, the families of affected individuals are expected to identify this symptom early on and present the affected individual for screening or examination at a health care facility. © 2021, Associacao Arquivos de Neuro-Psiquiatria. All rights reserved. |
Alzheimer disease; Dementia; Family; Memory disorders |
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Associacao Arquivos de Neuro-Psiquiatria |
19805764 |
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Article |
Q3 |
540 |
9365 |
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773 |
Rahman Y., Krisanti R.I.A., Wisnu W., Sitohang I.B.S. |
57225022226;57210797305;57200425452;56734569200; |
The comparison between free thyroxine and thyroid-stimulating hormone levels on melasma severity: A cross-sectional study |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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426 |
431 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108964003&doi=10.3889%2foamjms.2021.5952&partnerID=40&md5=b495093253a6b484fb6b524298865e4d |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia |
Rahman, Y., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia; Krisanti, R.I.A., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia; Wisnu, W., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia; Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia |
BACKGROUND: Melasma has been suspected to be linked with levels of thyroid hormone. There is no study that explains the association between thyroid hormone levels with melasma severity. AIM: This study aims to find the discrepancies in the levels of thyroid hormone in varying severity of melasma using two different measurement techniques. METHODS: Subjects were chosen consecutively from the dermatology clinic at RSUPN Dr. Cipto Mangunkusumo hospital. Forty-eight patients participated in this study were categorized into mild melasma and moderate-severe melasma based on modified melasma area and severity index (mMASI) and Janus II measurement. RESULTS: Statistically, mMASI measurement showed no significant association between varying melasma severity with levels of thyroid stimulating hormone and free T4 (FT4), p = 0.375 and p = 0.208, respectively. The Janus II examination using polarized light modality has a weak positive correlation with the serum FT4 level (r = 0.3; p = 0.039). Weak correlation was also found between the two measurement strategies, Janus II and mMASI (r = 0.314; p = 0.03). CONCLUSION: There are no significant differences observed in levels of thyroid hormone between subjects with varying degrees of melasma severity. © 2021 Yusnita Rahman, Roro Inge Ade Krisanti, Wismandari Wisnu, Irma Bernadette S. Sitohang. |
Free T4; Janus II facial analysis system; Melasma; Modified melasma area and severity index; Thyroid-stimulating hormone |
thyrotropin; adult; Article; chloasma; clinical article; cross-sectional study; disease severity; female; free thyroxine index; human; male |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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774 |
Atmakusuma T.D., Girson R., Koesnoe S. |
57216961785;14324834100;26028015000; |
Correlations between Iron Load and CD4 in Adult Transfusion-Dependent Beta Thalassemia |
2021 |
Anemia |
2021 |
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5549503 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108909049&doi=10.1155%2f2021%2f5549503&partnerID=40&md5=86934d2b70e3a64770f20d2512ea4dfb |
Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia; Division of Allergy-Immunology, Department of Internal Medicine. Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia; Girson, R., Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia; Koesnoe, S., Division of Allergy-Immunology, Department of Internal Medicine. Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia |
Background. Thalassemia is a hereditary disease, and severe anemia is the main phenotype of major thalassemia. Furthermore, the most important method in the management of this disease is red blood cell transfusion. Regular transfusions administered 1 or 2 times every month improve prognosis and survival. However, there is higher risk of infections and iron overload, especially in transfusion-dependent thalassemia (TDT). Infections are the second leading cause of death in adult TDT, after heart failure. Higher risk of infection is also influenced by multiple blood transfusions which causes alteration in immune response due to alloimmunization, transfusion-related infections, and iron overload. Meanwhile, iron overload in TDT alters both innate and specific immune responses. Furthermore, previous studies have shown the correlation between ferritin with CD4, but this has not been carried out in Indonesia. Therefore, this study aims to determine the correlations between iron overload (serum ferritin and transferrin saturation) and specific immune cells (CD4). Methods. This is a cross-sectional study, and a total number of 64 subjects were examined consecutively. Chest X-ray and blood sera were obtained. The total number of subjects was 64. The seromarkers HBsAg, anti-HCV, and anti-HIV were tested using the ELISA method. Serum ferritin and transferrin saturation was tested using ECLIA, and lymphocyte subsets were analyzed using flowcytometry. Meanwhile, the correlation between variables was determined using Spearman's test. Results. The results showed that 4.9% subjects were HBsAg positive, 10.7% were anti-HCV positive, and none were anti-HIV positive. There were 4 subjects with lung tuberculosis based on the 41 chest X-ray. Meanwhile, there was a weak negative and insignificant correlation between serum ferritin with CD4 (p=0.75; r = -0.04) and a weak positive and insignificant correlation between transferrin saturation with CD4 (p=0.133; r = 0.19). Conclusion. There were no correlations between iron overload (ferritin) and cellular immunity (CD4) in adult transfusion-dependent thalassemia. © 2021 Tubagus Djumhana Atmakusuma et al. |
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C reactive protein; ferritin; hemoglobin; hepatitis B surface antigen; hepatitis C antibody; Human immunodeficiency virus antibody; iron chelating agent; transferrin; tuberculostatic agent; adult; antibiotic therapy; antibody detection; antigen detection; Article; beta thalassemia; blood sampling; blood transfusion; CD4 lymphocyte count; cellular immunity; chronic hepatitis; coinfection; cross-sectional study; disease association; electrochemiluminescence immunoassay; enzyme linked immunosorbent assay; facies; female; ferritin blood level; flow cytometry; hemoglobin blood level; hemoglobin E-beta thalassemia; hepatitis B; hepatitis C; human; human cell; Human immunodeficiency virus infection; iron overload; leukocyte count; lung tuberculosis; lymphocyte subpopulation; major clinical study; |
Hindawi Limited |
20901267 |
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Article |
Q2 |
921 |
4948 |
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775 |
Estiasari R., Diwyacitta A., Sidik M., Rida Ariarini N.N., Sitorus F., Marwadhani S.S., Maharani K., Imran D., Arpandy R.A., Pangeran D., Hakim M. |
55240204000;57225009324;56252760000;57225009527;57208331594;57203760168;57189235094;57203976849;49361070700;57203764449;57216861859; |
Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up |
2021 |
Neurology Research International |
2021 |
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5573839 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108905101&doi=10.1155%2f2021%2f5573839&partnerID=40&md5=7aaf49b7f8adca76fa739b0330ba1aff |
Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Ophtalmology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Estiasari, R., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Diwyacitta, A., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Sidik, M., Department of Ophtalmology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Rida Ariarini, N.N., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Sitorus, F., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Marwadhani, S.S., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Maharani, K., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Imran, D., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Arpandy, R.A., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Pangeran, D., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Hakim, M., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background. Multiple sclerosis (MS) is an autoimmune disease characterized by inflammation and demyelination of the central nervous system which often involves the optic nerve even though only 20% of the patients experience optic neuritis (ON). Objective. This study aims to compare the retinal structure and optic nerve function between patients with MS and healthy controls (HCs), evaluate optic nerve alterations in MS over 1-year follow-up, and analyze its correlations with disease duration, number of relapses, degree of disability, and different subtypes. Methods. This is a prospective cohort study involving 58 eyes of MS patients. Optic nerve function was evaluated with best-corrected visual acuity (BCVA), contrast sensitivity, and P100 latency, while the retinal structure was evaluated from the GCIPL and RNFL thickness measured with optical coherence tomography (OCT) and fundus photography. Results. The MS group had lower BCVA (p=0.001), contrast sensitivity (p<0.001), mean GCIPL thickness (p<0.001), and mean RNFL thickness (p<0.001) than HC. At 6 and 12 months of observations, GCIPL and RNFL (nasal quadrant) of MS patients decreased significantly (p=0.007 and p=0.004, respectively). Disease duration and the number of relapses correlated with delayed P100 latency (r = -0.61, p<0.001 and r = -0.46, p=0.02). GCIPL and RNFL in the SPMS subtype were thinner than in RRMS. Conclusions. The retinal structure and optic nerve function of MS patients are worse than those of normal individuals. GCIPL and RNFL thinning occurs at 6 and 12 months but do not correlate with disease duration, the number of relapses, and degree of disability. © 2021 Riwanti Estiasari et al. |
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Hindawi Limited |
20901852 |
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Article |
Q3 |
365 |
12980 |
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776 |
Liem I.K., Oktavina R., Zakiyah, Anggraini D., Deraya I.E., Kodariah R., Krisnuhoni E., Wuyung P.E. |
55802927800;57224993301;57224999441;57225000673;57216313121;14010667100;35310982200;57192889605; |
Intravenous injection of umbilical cord-derived mesenchymal stem cells improved regeneration of rat liver after 2aaf/ccl4-induced injury |
2021 |
OnLine Journal of Biological Sciences |
21 |
2 |
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317 |
326 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108885347&doi=10.3844%2fojbsci.2021.317.326&partnerID=40&md5=e4defc3d20063b1647d2241805bc3694 |
Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell and Tissue Engineering Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine and Health Science, Universitas Kristen Krida Wacana, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Yarsi, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Animal Research Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Liem, I.K., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktavina, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine and Health Science, Universitas Kristen Krida Wacana, Jakarta, Indonesia; Zakiyah, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Universitas Yarsi, Jakarta, Indonesia; Anggraini, D., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Deraya, I.E., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kodariah, R., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Krisnuhoni, E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wuyung, P.E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Animal Research Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
The effectivity of Mesenchymal Stem Cell (MSC) therapy for chronic liver injury is still questioned due to its possibility to have a pro-fibrotic effects. Other consideration is the preferably peripheral Intravenous (IV) route of application rather than direct to the target organ, such as portal vein or splenic vein, since the most of MSC will be trapped in the lung and other organs. Therefore, a study has been carried out in an animal model of chronic liver injury, 2AAF/CCl4 rats, to find out whether IV injection of single dose, 1×106 human umbilical cord-derived MSC (hUC-MSC) can regenerate the liver tissue and reduce the fibrosis. Male Wistar rats (n = 18, 8 weeks, 160-200 g) were divided into three groups of six rats, i.e., group I (control/healthy rats), group II (2AAF/CCl4-induced liver injury with hUC-MSC injected rats) and group III (2AAF/CCl4-incuded liver injury without hUC-MSC injected rats). Gross anatomical features of the livers and blood examination were tested. There was no significant different of the Alanine Aminotransferase (ALT) and Albumin serum level between groups; however there was a tendency of ALT decrease and Albumin increase in stem cells treated rats (group II). Histopathological observation using hematoxylin eosin and Masson’s trichrome staining showed an improvement in the liver damage condition (reduction of necrosis and coverage area of fat degeneration) and an improvement in the fibrosis condition in the group II compared to the group III. None of group II rat had fallen into cirrhosis as seen in group III. Immunohistochemistry staining against Caspase 3 (biomarker for apoptosis) also showed significant reduction (p = 0.038; Tukey multiple comparison test) of group II expression index (2.74%) compared to the group III (8.64%). In conclusion, IV injection of single dose, 1×106 hUC-MSC could regenerate the liver tissue and reduce the fibrosis in 2AAF/CCl4 rats model of chronic liver injury. © 2021 Isabella Kurnia Liem, Reni Oktavina, Zakiyah, Dian Anggraini, Irwina Eka Deraya, Ria Kodariah, Ening Krisnuhoni, and Puspita Eka Wuyung. |
2AAF/CCl4; Caspase 3; Liver Fibrosis; Liver Injury; Liver Regeneration; MSC |
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Science Publications |
16084217 |
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Article |
Q4 |
152 |
23000 |
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777 |
Sanjay S., Leo S.W., Au Eong K.G., Adriono G.A., Fong K.C.S., Anand K., Kadarisman R.S., Granet D.B., Mahendradas P., Shetty R., Souza S.D., Iyer S.P. |
24315097100;7004356152;7003590870;57199540275;57224986711;57205395095;6508028541;6701767974;16481136500;23478872600;57224976208;55828761800; |
Global Ophthalmology Practice Patterns during COVID-19 Pandemic and Lockdown |
2021 |
Ophthalmic Epidemiology |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108832186&doi=10.1080%2f09286586.2021.1934037&partnerID=40&md5=ba28f0a2d64e8a2f774b4efdf3e9b346 |
Department of Uvea and Ocular Immunology, Narayana Nethralaya, Bengaluru, India; Dr Leo Adult Paediatric Eye Specialist Pte Ltd, Mount Elizabeth Medical Centre, Singapore; International Eye Cataract Retina Center, Mount Elizabeth Medical Center and Farrer Park Medical Center, Singapore; Department of Ophthalmology Visual Sciences, Khoo Teck Puat Hospital, Singapore; Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Mangunkusumo Hospital, Jakarta, Indonesia; OasisEye Specialists, Kuala Lumpur, Malaysia; Great Plains Health Callahan Cancer Center, University of Nebraska, North PlatteNE, United States; Aini Eye Clinic, Jakarta Hospital, Jakarta, Indonesia; Ratner Children’s Eye Center, Shiley Eye Institute, University of California, San Diego, United States; Department of Cornea and Refractive Services, Narayana Nethralaya, Bengaluru, India; Department of Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, United States |
Sanjay, S., Department of Uvea and Ocular Immunology, Narayana Nethralaya, Bengaluru, India; Leo, S.W., Dr Leo Adult Paediatric Eye Specialist Pte Ltd, Mount Elizabeth Medical Centre, Singapore; Au Eong, K.G., International Eye Cataract Retina Center, Mount Elizabeth Medical Center and Farrer Park Medical Center, Singapore, Department of Ophthalmology Visual Sciences, Khoo Teck Puat Hospital, Singapore; Adriono, G.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Mangunkusumo Hospital, Jakarta, Indonesia; Fong, K.C.S., OasisEye Specialists, Kuala Lumpur, Malaysia; Anand, K., Great Plains Health Callahan Cancer Center, University of Nebraska, North PlatteNE, United States; Kadarisman, R.S., Aini Eye Clinic, Jakarta Hospital, Jakarta, Indonesia; Granet, D.B., Ratner Children’s Eye Center, Shiley Eye Institute, University of California, San Diego, United States; Mahendradas, P., Department of Uvea and Ocular Immunology, Narayana Nethralaya, Bengaluru, India; Shetty, R., Department of Cornea and Refractive Services, Narayana Nethralaya, Bengaluru, India; Souza, S.D., Department of Cornea and Refractive Services, Narayana Nethralaya, Bengaluru, India; Iyer, S.P., Department of Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, United States |
Aim: To assess the impact of practice patterns amongst global ophthalmologists during severe acute respiratory syndrome Coronavirus 2 (SARS Cov2) causing Corona virus disease (COVID-19) and understand the various modifications made to address emergency surgeries and practice needs. Methods: An online survey was sent to practicing ophthalmologists around the world through email, Whatsapp™ ListServ17.0™ (for pediatric ophthalmologists), WeChat™ (China) and ophthalmology associations (Indonesia, Philippines, Ireland). All queries were collected and categorized. Responses to the queries were given according to the recommendations by the Ophthalmology association. Practices ability to deal with the COVID were also classified according to country and type of access to PPE. Statistical analyses of the association between these data and queries, where appropriate were carried out. Results: One thousand nine hundred sixteen ophthalmologists were invited to participate in a survey between April 10th and April 30th, 2020 of which 1207 responded, which is a response rate of approximately 63%. The majority of respondents were from India, Indonesia, China, Singapore and the USA. Our study indicates a precipitous drop in surgical procedures with 46% (n = 538) ophthalmologists ceased to operate on their patients and almost 40% (n = 486) were doing less than 25% of their original number of surgeries. The intent to resume elective surgeries was a consideration in 41% (n = 495) after an evaluation of the situation and in consultation with professional bodies. More than 2/3 of the respondents (n = 703) made it a priority to use and mandate their patients to practice physical distancing, wearing masks, and hand dis-infection for protection to limit the spread of infection. Conclusion: This global survey provides a real-world assessment of diverse practices that were in various forms of “shut down mode” and circumstances with varying capabilities to deal with COVID. It is unprecedented that the collective wisdom for a curtailment of practice has had an enormous immediate and far reaching implications on the livelihoods of ophthalmologists, their staff, and their families. Nevertheless, ophthalmologists and their staff remain resilient and have adapted to these changes pragmatically. © 2021 Taylor & Francis Group, LLC. |
COVID19; ophthalmic surgery; outpatient consultations; PPE; telehealth |
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Taylor and Francis Ltd. |
09286586 |
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Article |
Q2 |
728 |
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778 |
Miftahussurur M., Windia A., Syam A.F., Nusi I.A., Alfaray R.I., Fauzia K.A., Kahar H., Purbayu H., Sugihartono T., Setiawan P.B., Maimunah U., Kholili U., Thamrin H., Vidyani A., Doohan D., Waskito L.A., Rezkitha Y.A.A., Siregar G.A., Yamaoka Y. |
56323903000;57224923195;8443384400;56543515200;57215962996;57204649404;57218903823;57194162048;57194156387;6507682592;56543645400;57209663659;57204648560;57211316314;57204644036;57192177367;56543533600;56483277100;55183784100; |
Diagnostic value of 14C urea breath test for Helicobacter pylori detection compared by histopathology in indonesian dyspeptic patients |
2021 |
Clinical and Experimental Gastroenterology |
14 |
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291 |
296 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108652378&doi=10.2147%2fCEG.S306626&partnerID=40&md5=ed8411e8e8e3e089aef5e0d750c1da27 |
Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Faculty of Medicine, University of Muhammadiyah Surabaya, East Java, Surabaya, 60113, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatra Utara, Medan, 20155, Indonesia |
Miftahussurur, M., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia, Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Windia, A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Nusi, I.A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Alfaray, R.I., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Fauzia, K.A., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Kahar, H., Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Purbayu, H., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Sugihartono, T., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Setiawan, P.B., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Maimunah, U., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Kholili, U., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Thamrin, H., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Vidyani, A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Doohan, D., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Waskito, L.A., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Rezkitha, Y.A.A., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia, Faculty of Medicine, University of Muhammadiyah Surabaya, East Java, Surabaya, 60113, Indonesia; Siregar, G.A., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatra Utara, Medan, 20155, Indonesia; Yamaoka, Y., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan |
Purpose: Histopathology method is often used as a gold standard diagnostic for Helicobacter pylori infection in Indonesia. However, it requires an endoscopic procedure which is limited in Indonesia. A non-invasive method, such as14C Urea Breath Test (UBT), is more favorable; however, this particular method has not been validated yet. Patients and Methods: A total of 55 dyspeptic patients underwent gastroscopy and14C-UBT test. We used Heliprobe® UBT for UBT test. As for the histology, May-Giemsa staining of two gastric biopsies (from the antrum and corpus) were evaluated following the Updated Sydney System. Results: The Receiver Operating Characteristics analysis showed that the optimum cut-off value was 57 with excellence Area under Curve = 0.955 (95% CI = 0.861–1.000). By applying the optimum cut-off value, Heliprobe® UBT showed 92.31% for sensitivity, 97.62% for specificity, 92.31% for positive predictive value, 97.62% for negative predictive value, 38.77 for positive likelihood ratio, 0.0788 for negative likelihood ratio, and 96.36% for the accuracy. Conclusion: The14C-UBT is an accurate test for H. pylori diagnosis with excellent sensitivity, specificity, and accuracy. The different optimum cut-off points suggested that a validation is absolutely necessary for new test prior application to the new population. © 2021 Miftahussurur et al. |
Diagnostic; Helicobacter pylori; Infectious disease; UBT |
urea c 14; adult; Article; bacterium identification; controlled study; cross-sectional study; diagnostic accuracy; diagnostic value; dyspepsia; female; gastroscopy; Helicobacter infection; Helicobacter pylori; histopathology; human; human tissue; Indonesian; intermethod comparison; major clinical study; male; May Giemsa staining; middle aged; negative likelihood ratio; nonhuman; positive likelihood ratio; predictive value; receiver operating characteristic; sensitivity and specificity; statistical analysis; stomach antrum; stomach biopsy; stomach corpus; urea breath test; validation study |
Dove Medical Press Ltd |
11787023 |
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3723 |
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779 |
Kartika R.W., Alwi I., Suyatna F.D., Yunir E., Waspadji S., Immanuel S., Silalahi T., Sungkar S., Rachmat J., Bardosono S., Reksodiputro M.H. |
57223447932;15055173800;56039633100;36520254800;8678136400;12777341300;56275255400;57016857300;6507225348;21933841000;35090488800; |
Advance-Platelet Rich Fibrin and Hyaluronic Acid Combination Improves Interleukin-6 and Granulation Index in Diabetic Foot Ulcer Patients |
2021 |
Indonesian Biomedical Journal |
13 |
2 |
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170 |
177 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108646812&doi=10.18585%2finabj.v13i2.1501&partnerID=40&md5=38a4d6d4cd5994b04badcabc1939a76e |
Doctoral Program in Medical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Thoracic, Cardiac and Vascular Surgery, Krida Wacana Christian University, Jl. Arjuna Utara No.6, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Internal Medicine, Krida Wacana Christian University, Jl. Arjuna Utara No.6, Jakarta, Indonesia; Department of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia |
Kartika, R.W., Doctoral Program in Medical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Thoracic, Cardiac and Vascular Surgery, Krida Wacana Christian University, Jl. Arjuna Utara No.6, Jakarta, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Krida Wacana Christian University, Jl. Arjuna Utara No.6, Jakarta, Indonesia; Sungkar, S., Department of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Rachmat, J., Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Reksodiputro, M.H., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia |
BACKGROUND: Diabetic foot ulcer (DFU) is the most common and threatening complication of Diabetes Mellitus (DM). Ideal wound dressing for DFU management should relieve symptoms, provide wound protection, and encourage healing. Advanced-Platelet Rich Fibrin (A-PRF) and Hyaluronic Acid (HA) have been proven to improve wound healing process. This study was aimed to demonstrate the ability of combination of A-PRF and HA in reducing inflammation and improving DFU tissue healing. METHODS: Twenty DFU subjects were involved in this study, and divided into two groups based on the topical fibrin gel treatment: A-PRF + HA group and A-PRF only group. A-PRF was obtained by peripheral blood centrifugation. A-PRF + HA was prepared by homogening A-PRF and AH with a ratio of 1:0.6. Interleukin-6 (IL-6) level, granulation index (GI), numeric pain score (NPS), and inflammation clinical symptoms (ICS) were assessed on day-0, 3, 7 and 14. RESULTS: Wound swabs' IL-6 level on day-7 was found to be significantly lower in A-PRF + HA compared to A-PRF alone (p=0.041). The IL-6 level reduction also found to be significant higher either in wound swabs (day 0-7, p=0.015) or fibrin gel (day 0-3, p=0.049; day 0-7, p=0.034). A-PRF + HA treatment significantly increased the GI even since day-3 (p=0.043), with lower NPS (p<0.001), and ICS score. CONCLUSION: The combination of A-PRF and HA increases the GI in DFU healing by reducing the inflammation state which will induce the angiogenesis process, as well as reducing pain in DFU subjects better than A-PRF alone. © 2021. All Rights Reserved. |
angiogenesis; inflammation; interleukin-6; proliferation; wound healing |
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Prodia Education and Research Institute |
20853297 |
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Article |
Q4 |
160 |
22228 |
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780 |
Giantini A., Timan I.S., Listiyaningsih E., Dharma R., Setiabudy R., Alwi I., Partakusuma L.G., Indrasari N.D., Harahap· A.R., Suparmin· S., Sahar W., Sukmawan R. |
12776781400;6602793366;57224237184;12777817700;6602316235;15055173800;57224924047;6506289872;57224930255;57218100688;57224929934;8651025300; |
Comparison of Light Transmission Aggregometry and VerifyNow in Detecting Clopidogrel Resistance and Factors Affecting Clopidogrel Resistance in AMI-EST Patients Undergoing Percutaneous Coronary Intervention: A Cross-Sectional Study |
2021 |
Indonesian Biomedical Journal |
13 |
2 |
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163 |
169 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108601516&doi=10.18585%2finabj.v13i2.1477&partnerID=40&md5=2ade19315f56303e4e2ab7f2428ec652 |
Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia; Department of Internal Medicine, Cardiology Division, Metropolitan Medical Centre (MMC) Hospital, Jl. H.R. Rasuna Said Kav. C-21, Jakarta, Indonesia; Eijkman Institute, Jl. Pangeran Diponegoro No. 69, Jakarta, Indonesia |
Giantini, A., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Timan, I.S., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Listiyaningsih, E., Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia; Dharma, R., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Setiabudy, R., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Alwi, I., Department of Internal Medicine, Cardiology Division, Metropolitan Medical Centre (MMC) Hospital, Jl. H.R. Rasuna Said Kav. C-21, Jakarta, Indonesia; Partakusuma, L.G., Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia; Indrasari, N.D., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Harahap·, A.R., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Eijkman Institute, Jl. Pangeran Diponegoro No. 69, Jakarta, Indonesia; Suparmin·, S., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Sahar, W., Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia; Sukmawan, R., Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia |
BACKGROUND: Light transmission aggregometry (LTA) and VerifyNow is commonly used to measure platelet responsiveness to clopidogrel. This study aimed to compare the results of LTA and VerifyNow P2Y12 assay for assessing the clopidogrel resistance in patients undergoing percutaneous coronary intervention and determine factors affecting clopidogrel resistance. METHODS: The subjects were 119 patients who underwent percutaneous coronary intervention (PCI) and had given loading dose of 600 mg clopidogrel. Blood samples were taken at 6 hour after clopidogrel loading dose. Platelet aggregation was measured by LTA and Verify Now. RESULTS: LTA and VerifyNow assay showed fair agreement with Kappa=0.270, p=0.001. The proportion of resistance to clopidogrel using VerifyNow was 21.8% and LTA was 47.1%. Patients with diabetes melitus were more likely to develop clopidogrel resistance than patients without diabetes (OR of 7.67; 95% CI: 1.87-31.50; p=0.005). CONCLUSION: The ability of LTA and VerifyNow in detecting clopidogrel resistance were not comparable. Multivariate analysis results for VerifyNow shows diabetes mellitus as the greatest predictors of clopidogrel resistance. © 2021. All Rights Reserved. |
agreement; clopidogrel resistance; LTA; predictor; VerifyNow |
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Prodia Education and Research Institute |
20853297 |
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Article |
Q4 |
160 |
22228 |
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