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310 |
Situmorang H., Hestiantoro A., Purbadi S., Flamandita D., Sahlan M. |
57195939562;8743255100;6505677307;57216766308;57189182661; |
IN-SILICO dynamic analysis of Sulawesi propolis as anti-endometriosis drug: Interaction study with TNF alpha receptor, NF-kB, estrogen receptor, progesterone receptor and prostaglandin receptor |
2021 |
Annals of Medicine and Surgery |
67 |
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102459 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109547312&doi=10.1016%2fj.amsu.2021.102459&partnerID=40&md5=0f7d6fdeda084de97c22a80f60f7b2a7 |
Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Fuad Hasan, Pancoran MAS, Kukusan, Beji, Depok City, West Java 16424, Indonesia |
Situmorang, H., Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Hestiantoro, A., Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Purbadi, S., Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Flamandita, D., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Fuad Hasan, Pancoran MAS, Kukusan, Beji, Depok City, West Java 16424, Indonesia; Sahlan, M., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Fuad Hasan, Pancoran MAS, Kukusan, Beji, Depok City, West Java 16424, Indonesia |
Introduction: Endometriosis is a disease that impacts around 10% of all women in reproductive age, with pelvic pain and infertility as its main clinical features. Current medical treatment targeting lowering estrogen activity has not shown sufficient result due its side effects and reproductive function suppression. Propolis has been widely studied, showing anti inflammation and pro-apoptosis property, that could potentially be used in the treatment of endometriosis. This study investigates the interaction between Sulawesi Propolis’ active components and receptors and protein related to endometriosis pathogenesis. Methods: Active components of Sulawesi Propolis were initially identified with their targeted protein receptors. Lipinski rules were used to screen potential components. The ligands and proteins were tested using Autodock program to predict the most active compound and possible binding sites between propolis and some target proteins associated with inflammatory and apoptotic activity in endometriosis models. Receptor modelling is then performed using Swiss-Model. Results: These active components of Sulawesi Propolis showed a strong binding potential towards TNF- α, NF-kb, Estrogen-α, Estrogen-β, progesterone B, PGE2 EP2 and EP3 subtype respectively: Sanggenon C, Sanggenon H, Epicryptoacetalide, Chrysin-7-O-β-D-glucopyranodside, Irilone, Polydatin and Epicryptoacetalide. Compared to its negative ligand, Sulawesi Propolis displayed a stronger binding capacity to TNF-α, Estrogen-α, and Progesterone B receptors. Conclusion: Sulawesi Propolis has the ability to interact with receptors related to reproductive function, apoptotic reactions and inflammatory processes, a significant factor associated with the pathogenesis of endometriosis. © 2021 |
Docking; Endometriosis; Estrogen receptor; In silico; NF-kB; Progesterone receptor; Propolis; Prostaglandin receptor; TNF alpha Receptor |
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Elsevier Ltd |
20490801 |
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391 |
12334 |
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316 |
Widodo D.W., Dewi D.J., Ranakusuma R.W., Irawati Y. |
56644646600;57219323765;57189729404;57201260313; |
Evaluation of 3 and 2-point internal fixation in the management of zygomaticomaxillary complex fractures: Case report |
2021 |
Annals of Medicine and Surgery |
67 |
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102539 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109176909&doi=10.1016%2fj.amsu.2021.102539&partnerID=40&md5=aa5581548a2394f973a5958f289f0999 |
Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Widodo, D.W., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Dewi, D.J., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ranakusuma, R.W., Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Irawati, Y., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: The ZMC has a prominent shape compared to other parts in the midfacial region, thus small injuries will generate fractures in the ZMC. The management of ZMC fracture depends on the fracture deformity and the surgeon's considerations. Various studies have revealed the success of ZMC reconstruction with one fixation point to 4 fixation points fitting to the tetrapod shape. Case report: We report two cases of ZMC fractures which comparing the efficacy of 3- and 2-point internal fixations for improving clinical outcomes The first patient underwent ORIF which placed at 2 fixation points, the first point in the left ZF suture and the second point in the left ZMB. The second patient underwent ORIF reconstruction at 3 fixation points, the first point in the right inferior orbital rim, the second point in the right ZF suture, and the third point in the right ZMB. Discussion: The most common surgical approach for ZMC fractures is through a gingivobuccal groin incision. This approach is for body exposure of the ZMB, which is the main buttress. The 3-point internal fixation improved the postoperative clinical outcome of fracture fragment stability compared to two-point fixation, but the mean malar height projection, vertical dystopia, and enophthalmos were not different between the two fixation methods. Conclusion: Three-point internal fixation can improve the clinical outcome of fracture fragment stability compared to 2-point fixation; however, it has a mean operative duration 22.2 minutes longer than 2-point fixation, so its application must be considered during the COVID-19 pandemic. © 2021 The Authors |
Case report; Internal fixation; Zygomatic fracture; Zygomaticomaxillary fracture |
adult; Article; cartilage graft; case report; clinical article; comparative effectiveness; computer assisted tomography; coronavirus disease 2019; endotracheal intubation; enophthalmos; female; general anesthesia; heterotopia; human; inguinal region; maxilla fracture; maxillofacial surgery; nose cavity; open fracture reduction; osteosynthesis; pandemic; physical examination; visual acuity; zygoma arch fracture |
Elsevier Ltd |
20490801 |
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391 |
12334 |
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317 |
Hutauruk S.M., Hermani B., Monasari P. |
57205105620;14325051100;57224812004; |
Role of chlorhexidine on tracheostomy cannula decontamination in relation to the growth of Biofilm-Forming Bacteria Colony- a randomized controlled trial study |
2021 |
Annals of Medicine and Surgery |
67 |
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102491 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108345034&doi=10.1016%2fj.amsu.2021.102491&partnerID=40&md5=a3d916bc24eff149d6342e51ea55083d |
ENT-Head and Neck Department, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia |
Hutauruk, S.M., ENT-Head and Neck Department, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia; Hermani, B., ENT-Head and Neck Department, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia; Monasari, P., ENT-Head and Neck Department, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia |
Background: Regular cleaning of the cannula in the trachea is very important for infection prevention. How to wash the tracheal cannula which is good to reduce the possibility of colonies of biofilm-forming bacteria and the growth of bacterial and the pattern of bacterial on the tracheal cannula is still unknown. This study aims to evaluate the efficacy of decontamination of the tracheal cannula using chlorhexidine and NaCl 0.9% in patients using the tracheal cannula to decrease biofilm-forming bacterial colony. Methods: 40 subjects were grouped into 20 subjects in the control group washing the cannula using 0.9% NaCl and the interventional group washing cannula using and with 2.5% chlorhexidine solution and 0.9% NaCl. This study used a parallel randomized controlled trial of 2 groups with a single blinded. Results: 40 subjects studied, 17 subjects (85%) each group produced biofilm-forming bacteria prior to intervention. After intervention in the study group, 15 subjects were biofilm negative and 5 biofilm positive subjects p = 0.001. The most common bacteria found in the control group is Pseudomonas aeruginosa, while in the study group some bacteria such as Acinetobacter sp. and Proteus mirabilis. Amoxicilin-Clavulanate had the highest resistance to biofilm forming bacteria in both groups. Piperacillin, ceftazidime, ciprofloxacin and meropenem have the highest sensitivity to biofilm-forming bacteria. Conclusion: There was a significant decrease in the number of colonies that produced biofilm in the tracheal cannula in the study group compared to the control group in tracheal cannula washing. © 2021 The Authors |
Bacteria colony; Biofilms; Chlorhexidine; Tracheostomy cannulae |
amoxicillin plus clavulanic acid; ceftazidime; chlorhexidine; ciprofloxacin; meropenem; piperacillin; sultamicillin; adult; aged; antibacterial activity; antibiotic resistance; Article; bacterial growth; bacterium colony; biofilm; clinical article; controlled study; decontamination; diabetes mellitus; Escherichia coli; human; hypertension; malnutrition; Proteus mirabilis; Pseudomonas aeruginosa; randomized controlled trial; single blind procedure; Staphylococcus aureus; tracheostomy |
Elsevier Ltd |
20490801 |
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391 |
12334 |
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370 |
Purbadi S., Rustamadji P., Purwoto G., Kusuma F., Putra A.D., Scovani L., Sianturi E.T. |
6505677307;55321572200;14720170400;57192911548;57208996180;57223440213;57223430479; |
Skin metastases originated from cervical cancer: A rare case report |
2021 |
Annals of Medicine and Surgery |
66 |
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102363 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105852603&doi=10.1016%2fj.amsu.2021.102363&partnerID=40&md5=6edeeefd66a3289a6bb1540f0adc31fe |
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo National Referral Hospital, Indonesia |
Purbadi, S., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rustamadji, P., Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo National Referral Hospital, Indonesia; Purwoto, G., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kusuma, F., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Putra, A.D., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Scovani, L., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sianturi, E.T., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Metastases in cervical cancer could be spread through direct local invasion, lymphatic dissemination, or hematogenous dissemination. The most common sites of distant metastases are lungs, bone, and liver. Skin metastases from cervical cancer are categorized as a rare occurrence of metastases. This rarity of the cases has led us to report it. Case description: A 66-year-old multiparous woman diagnosed with stage IIA cervical cancer seven years ago, then she came into our outpatient clinic complained about a brownish white color mass on the left side of the neck that keeps getting bigger over time came from a skin lesion. The lesion was first treated with topical steroid but there was no improvement. Biopsy was done and the result showed a carcinoma metastasis that led to adenosquamous carcinoma or cervical adenocarcinoma. The patient went through chemoradiation with biosensitizer paclitaxel 120 mg/m2 for six cycles, which began in August 2019 until October 2019. The treatment progress showed a promising result. We observed the patient during treatment until two months after finishing the treatment. At the last visit, the patient came to our outpatient clinic, the mass size decreased significantly, and the skin showed an excellent regeneration sign. Conclusion: The physicians should always consider the patient's history and pay more attention to skin lesions in patients with a history of cervical cancer. The physicians should also perform a thorough physical examination and biopsy to confirm the diagnosis. © 2021 The Author(s) |
Cervical cancer; Skin lesion; Skin metastasis |
paclitaxel; adenocarcinoma; adenosquamous carcinoma; aged; anemia; Article; attention; body weight; brain metastasis; cancer patient; case report; chemoradiotherapy; clinical article; cutaneous leishmaniasis; distant metastasis; drug industry; female; histopathology; human; human tissue; hysterectomy; laparotomy; mammography; metastasis; multipara; ovariectomy; physical examination; physician; regeneration; sexual behavior; skin defect; skin metastasis; thrombocytopenia; uterine cervix adenocarcinoma; uterine cervix cancer; vaginal secretion |
Elsevier Ltd |
20490801 |
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391 |
12334 |
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372 |
Reksodiputro M.H., Harahap A.R., Siregar N.C., Malik S.G., Bashirudin J., Boesoirie M.T.S., Widodo D.W., Iljanto S., Sajuthi D., Sukrisman L., Yosia M. |
35090488800;6507325543;6508087790;7402973374;57223288901;57223301168;56644646600;57223273746;6603075144;8661764000;57204933098; |
Comparison between PRP and PRFM on FTSG healing profile: Macroscopic, microscopic and ELISA evaluation |
2021 |
Annals of Medicine and Surgery |
66 |
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102350 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105502675&doi=10.1016%2fj.amsu.2021.102350&partnerID=40&md5=632e6c1f802e9603336c9a0770ecc410 |
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University of Padjajaran, Hasan Sadikin Hospital, Bandung, Indonesia; Faculty of Public Health, Centre for Health Administration, Management and Policy, Universitas Indonesia, Jakarta, Indonesia; Department of Clinics, Reproduction, and Pathology, Faculty of Veterinary Medicine, Institute Pertanian Bogor, Bogor, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Reksodiputro, M.H., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harahap, A.R., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Siregar, N.C., Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Malik, S.G., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Bashirudin, J., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Boesoirie, M.T.S., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University of Padjajaran, Hasan Sadikin Hospital, Bandung, Indonesia; Widodo, D.W., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Iljanto, S., Faculty of Public Health, Centre for Health Administration, Management and Policy, Universitas Indonesia, Jakarta, Indonesia; Sajuthi, D., Department of Clinics, Reproduction, and Pathology, Faculty of Veterinary Medicine, Institute Pertanian Bogor, Bogor, Indonesia; Sukrisman, L., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yosia, M., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Studies had shown the benefit of PRFM and PRP in wound healing but their use in skin graft healing was rarely studied. This study aims to compare the use of PRP and PRFM in accelerating wound healing process of skin full-thickness skin graft (FTSG). Materials and methods: Five pigs were used to look at the wound healing effect of PRP and PRFM usage prior to FTSG implantation. Subsequent punch biopsies were then conducted on the 1st, 3rd, 7th, 14th, and 30th day to obtain samples for macroscopic (skin color), extracellular matrix (collagen), microscopic (PMN, macrophage, and fibroblast), and ELISA (TGFβ1 and PDGF) analysis to determine the level of wound healing activity. ImageJ software was used to photograph for macroscopic and extracellular matrix analysis. Results: Macroscopic, extracellular matrix, and ELISA evaluation show no significant difference in FTSG survival rates for all treatment groups. Microscopic examination showed an increase in PMN, macrophage, and fibroblast levels with PRFM application showing higher increases in all observed microscopic variables compared to PRP and control. Conclusion: This study observed that both PRFM and PRP as autologous platelet preparation accelerate wound healing in FTSG, with PRFM being superior due to the higher number of PMN, macrophage, and fibroblast. © 2021 The Authors |
FTSG; PRFM; PRP; Wound healing |
atropine; collagen; collagen type 1; hemoglobin; isoflurane; ketamine; lidocaine; platelet derived growth factor; platelet-rich fibrin; transforming growth factor beta1; xylazine; animal experiment; animal model; animal tissue; Article; enzyme linked immunosorbent assay; exosome; extracellular matrix; female; fibroblast; full thickness skin graft; glomerulus filtration rate; graft survival; histology; macrophage; male; microscopy; neutrophil; nonhuman; platelet-rich plasma cell; punch biopsy; scientific literature; skin injury; survival rate; thrombocyte; wound healing |
Elsevier Ltd |
20490801 |
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12334 |
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410 |
Solichin I., Sandjaya G., Prabowo I., Dwi Putra N.H., Rhatomy S. |
57202813479;57223086553;57221098612;57223086083;57204509883; |
The lateral curved osteotomy for cubitus varus deformity in children: A case report and literature review |
2021 |
Annals of Medicine and Surgery |
65 |
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102315 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104767442&doi=10.1016%2fj.amsu.2021.102315&partnerID=40&md5=d2cf2846c9fa539b567bea0b5a8e358f |
Orthopaedic Hospital Purwokerto, Network Hospital of Department Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital, Indonesia; Soedarso Hospital Pontianak, Network Hospital of Department Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital, Indonesia; Department of Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sport and Adult Reconstruction Division, Department of Orthopedics and Traumatology, Dr. Soeradji Tirtonegoro General Hospital, Klaten, Indonesia; Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia |
Solichin, I., Orthopaedic Hospital Purwokerto, Network Hospital of Department Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital, Indonesia; Sandjaya, G., Soedarso Hospital Pontianak, Network Hospital of Department Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital, Indonesia; Prabowo, I., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Dwi Putra, N.H., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rhatomy, S., Sport and Adult Reconstruction Division, Department of Orthopedics and Traumatology, Dr. Soeradji Tirtonegoro General Hospital, Klaten, Indonesia, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia |
Introduction: Cubitus varus deformity after malunited supracondylar humerus fracture has various surgical techniques, implant configurations, and approaches. We describe a combination of French and Dome osteotomy and novel internal fixation technique to deliver an easy, safe, fast and reproducible result based on the current best evidence. Presentation of case: Two cases of malunited supracondylar humerus are described. The first case involves a 3-year-old girl who presented with outstretched and supinated left arm after falling during bike riding 3 weeks earlier. We found no abnormality in radial and median nerve function, but the left arm radiographs showed a callus formation and the early stages of a malunited fracture of the supracondylar humerus. We waited two months for further radiographic evaluation and the radiographs showed the malunited supracondylar humerus with elbow flexion of only 105° and elbow hyperextension of 20°. The cubitus varus was recorded with clinical carrying angle of varus 10°. We used a combination of original French and Dome osteotomy, lateral approach, and our novel fixation technique with excellent results. The second case involved a 8-year-old boy with malunited right elbow and the surgery was done in the same manner, with the result of restoration to normal elbow range of motion. We also assessed the pain score and disabilities of the arm, shoulder and hand (DASH) score and recorded satisfactory results. Conclusions: The combination of French and Dome osteotomy for treatment of cubitus varus deformity can provide an easy, safe, and reproducible result. © 2021 The Author(s) |
Cubitus varus deformity; Dome osteotomy; French osteotomy; Malunited supracondylar humerus |
Article; callus; case report; cerclage; child; clinical article; Disabilities of the Arm, Shoulder and Hand (score); disability; elbow flexion; elbow radiography; female; follow up; human; humeral supracondylar fracture; iatrogenic disease; male; nerve function; open reduction (procedure); osteotomy; pain; pain assessment; preschool child; range of motion; school child; varus deformity |
Elsevier Ltd |
20490801 |
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476 |
Kamal A.F., Abubakar I., Salamah T. |
56648996700;57204179162;57195380322; |
Alkaline phosphatase, lactic dehidrogenase, inflammatory variables and apparent diffusion coefficients from MRI for prediction of chemotherapy response in osteosarcoma. A cross sectional study |
2021 |
Annals of Medicine and Surgery |
64 |
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102228 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102644624&doi=10.1016%2fj.amsu.2021.102228&partnerID=40&md5=fd665964a20c5345b17f1145f1383619 |
Department of Orthopaedic and Traumatology Faculty of Medicine Universitas Indonesia/ Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Orthopaedic and Traumatology-Department of Surgery Faculty of Medicine Universitas Syiah Kuala/ Zainoel Abidin General Hospital, Banda Aceh, Indonesia; Department of Radiology Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo, General Hospital, Jakarta, Indonesia |
Kamal, A.F., Department of Orthopaedic and Traumatology Faculty of Medicine Universitas Indonesia/ Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Abubakar, I., Department of Orthopaedic and Traumatology Faculty of Medicine Universitas Indonesia/ Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Division of Orthopaedic and Traumatology-Department of Surgery Faculty of Medicine Universitas Syiah Kuala/ Zainoel Abidin General Hospital, Banda Aceh, Indonesia; Salamah, T., Department of Radiology Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo, General Hospital, Jakarta, Indonesia |
Background: This present study aimed to assess if clinical, laboratory and MRI were an accurate benchmark in assessing the effectiveness of neoadjuvant chemotherapy in osteosarcoma patients. Methods: This was an observational analytic study with a cross-sectional design. We correlated among clinical, laboratory and magnetic resonance imaging (MRI) data before and after neoadjuvant chemotherapy; and percentage of tumor necroses from osteosarcoma patients during the period between January 2017–July 2019. Results: Of the 58 patients included in this study, 38 were male and 20 were female aged 5 - 67 years (mean: 16-year-old. 37(63.8%) patients underwent neoadjuvant chemotherapy with CAI regimens and 13 (36.2%) with CA regiments. The tumors were classified as stage IIB in 43 (74.1%) patients and stage III in 15 (25.9%) patients. Wilcoxon test showed significant differences between alkaline phosphatase (ALP), erythrocyte sedimentation rate (ESR), and neutrophil to lymphocyte ratio (NLR) before and after neoadjuvant chemotherapy in the poor-response group. We found no significant difference between lactic dehydrogenase (LDH) and lymphocyte-to-monocyte ratio (LMR) before and after neoadjuvant chemotherapy in the good-response group. MRI revealed decreased tumor volume in patients in the good-response to chemotherapy. Conclusion: We demonstrated that ALP level was statistically significant in the poor-response group. We also found that LDH value before neoadjuvant chemotherapy had a strong correlation with degree of necrosis and could be used as a predictive indicator. MRI plays an important role in evaluating tumor volumes and preoperative radiological changes to predict histological necrosis. © 2021 |
Alkaline phospkatase; Chemotherapy; LDH; MRI Apparent diffusion coefficients; NLR,LMR; Osteosarcoma |
alanine aminotransferase; alkaline phosphatase; C reactive protein; cisplatin; doxorubicin; fluorodeoxyglucose f 18; ifosfamide; lactate dehydrogenase; adjuvant therapy; adolescent; adult; aged; analytical research; apparent diffusion coefficient; Article; cancer chemotherapy; cancer size; cancer staging; child; comparative effectiveness; computer assisted tomography; cross-sectional study; erythrocyte sedimentation rate; female; histology; human; human tissue; hypertransaminasemia; lymphocyte monocyte ratio; major clinical study; male; MSTS score; neoadjuvant chemotherapy; neutrophil lymphocyte ratio; nuclear magnetic resonance imaging; observational study; osteosarcoma; platelet lymphocyte ratio; receiver operating characteristic; retrospective study; scoring system; treatment response; |
Elsevier Ltd |
20490801 |
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536 |
Tua Lubis A.M., Budimansyah M., Made Febry Siswanto I.G., Yanuarso Y., Marsetio A.F. |
15122639800;57222168054;57222170597;57222173063;57192180884; |
Functional outcome of implant-free bone-patellar tendon autograft versus hamstring autograft in arthroscopic anterior cruciate ligament reconstruction: A prospective study |
2021 |
Annals of Medicine and Surgery |
63 |
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102184 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101786286&doi=10.1016%2fj.amsu.2021.102184&partnerID=40&md5=2c7a67ad1a6831d518d84971baadc9be |
Universitas Indonesia-Cipto Mangunkusumo General Hospital, Jl. Diponegoro No. 71, Jakarta, Pusat 10430, Indonesia; Persahabatan Hospital, Jl. Persahabatan Raya No.1, Jakarta, Timur 13230, Indonesia; Royal Progress Hospital, Jl. Danau Sunter Utara, Tanjung Priok, Jakarta, Utara 14350, Indonesia; Gatot Soebroto Army Hospital, Jl. Abdul Rahman Saleh Raya No.24, Senen, Jakarta, Pusat 10410, Indonesia |
Tua Lubis, A.M., Universitas Indonesia-Cipto Mangunkusumo General Hospital, Jl. Diponegoro No. 71, Jakarta, Pusat 10430, Indonesia; Budimansyah, M., Persahabatan Hospital, Jl. Persahabatan Raya No.1, Jakarta, Timur 13230, Indonesia; Made Febry Siswanto, I.G., Royal Progress Hospital, Jl. Danau Sunter Utara, Tanjung Priok, Jakarta, Utara 14350, Indonesia; Yanuarso, Y., Gatot Soebroto Army Hospital, Jl. Abdul Rahman Saleh Raya No.24, Senen, Jakarta, Pusat 10410, Indonesia; Marsetio, A.F., Universitas Indonesia-Cipto Mangunkusumo General Hospital, Jl. Diponegoro No. 71, Jakarta, Pusat 10430, Indonesia |
Introduction: The use of implant in anterior cruciate ligament (ACL) reconstruction has been associated with several drawbacks including graft injury, implant osteolysis, implant migration and soft tissue irritation. Implant-free ACL reconstruction surgery offers additional benefits of cost-effective, improved graft incorporation and ease of revision surgery. Our study aimed to compare the functional outcome of ACL reconstruction by using bone-patellar tendon autograft with press-fit fixation technique and hamstring autografts with implant. Methods: A prospective cohort study design was used. Between March 2013 and March 2014, 12 patients underwent patella tendon-bone graft fixated by press-fit fixation technique (implant-free), while 24 patients underwent ACL reconstruction using implant-fixated hamstring tendon graft. Objective functional outcome was measured by using rolimeter, and subjective functional outcome was measured according to the functional score of IKDC, Tegner-Lysholm and KOOS. Results: Both techniques have shown no significant difference in terms of functional outcome, whether assessed by rolimeter measurement, IKDC score, Tegner-Lysholm, KOOS score between implant group and implant-free group, preoperatively and postoperatively. Discussion: Our study results are in line with several other studies with various follow-up time and systematic review. With the right technique, graft harvesting of patella tendon-tibial tuberosity bone block can be successfully performed, and associated donor site morbidity can be avoided. Conclusion: Patients who underwent ACL reconstruction using implant-free technique by press-fit fixation had comparable outcome with ACL reconstruction with implant, objectively and subjectively. This technique should be further revisited and reevaluated. © 2021 The Authors |
Anterior cruciate ligament; Anterior cruciate ligament injury; Bone-patellar tendon; Implant-free ACL reconstruction; Press-fit fixation |
adult; anterior cruciate ligament reconstruction; arthroscopic surgery; Article; bone patellar tendon bone graft; cohort analysis; controlled study; female; follow up; graft harvesting; hamstring tendon; human; Knee Injury and Osteoarthritis Outcome Score; male; nuclear magnetic resonance imaging; press fit graft fixation technique; prospective study; randomized controlled trial; scoring system; soccer; Tegner activity score; Tegner-Lysholm Knee Scoring Scale; tibial tuberosity; traffic accident; volleyball |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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538 |
Seswandhana R., Makrufardi F., Sudjatmiko G. |
8718699600;57214993245;16025731000; |
Fistula incidence after primary repair and correlation with cleft width-to-palatum width ratio: A prospective cohort study |
2021 |
Annals of Medicine and Surgery |
63 |
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102183 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101659670&doi=10.1016%2fj.amsu.2021.102183&partnerID=40&md5=ad5a9021a2b2389751b7ee5f65e256ee |
Plastic, Reconstructive, and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia; Department of Plastic Reconstructive, and Aesthetic Surgery, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Seswandhana, R., Plastic, Reconstructive, and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia; Makrufardi, F., Plastic, Reconstructive, and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia; Sudjatmiko, G., Department of Plastic Reconstructive, and Aesthetic Surgery, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Cleft lip with or without cleft palate is one of the most common birth defects and is certainly the most visible. Fistula rate after primary palatoplasty was ranging between 10 and 23% and could be detected in the first three weeks after surgery. The cleft width is the frequent factor which was assumed to correspond to fistula occurrence. This study aimed to find correlation between fistula occurrence with cleft width and palatum width ratio after primary palate repair. Methods: A prospective cohort study was conducted on 16 subjects, which consisted of 10 males and 6 females. We measured width of cleft palate, width of rest palate and width of palate arch on three level measurements (posterior, junction and anterior). The surgery was performed using the two-flap and three layers suturing technique. Results: Sixteen patients were enrolled in this study during January and February 2008. Ten patients were diagnosed with unilateral cleft palate while six patients had bilateral cleft palate. Mean of age was 22.31 ± 5.86 month. Correlation analysis between fistula occurrence and cleft width, cleft width-remnant palate width ratio and cleft width-palate arch width ratio using logistic regression did not show statistical correlation, and the same result was found between fistula occurrence and hemoglobin level, white blood count, nutritional status, cleft type and caries dentis factors (p > 0.05). Conclusion: Width of the cleft is not a factor associated with fistula occurrence. Two-flap three layers technique could be considered as a simple technique and gives a low rate of fistula occurrence. © 2021 |
Cleft width and palate width ratio; Fistula occurrence; Primary palatoplasty; Two-flap three layers suturing technique |
amoxicillin; epinephrine; hemoglobin; lidocaine; paracetamol; anemia; anthropometry; Article; blood cell count; child; cleft palate; clinical article; cohort analysis; controlled study; correlation analysis; dental caries; female; fistula; gestational age; hemoglobin blood level; human; leukocyte count; major clinical study; male; nutritional status; obesity; palatoplasty; primary palate; prospective study; protein expression; suture technique |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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544 |
Dilogo I.H., Prabowo I. |
56161962800;57221098612; |
The role of angioembolization and C-clamp fixation: Damaged control orthopaedic in haemodynamically unstable pelvic fracture |
2021 |
Annals of Medicine and Surgery |
63 |
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102157 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101301928&doi=10.1016%2fj.amsu.2021.02.003&partnerID=40&md5=67b060a519b64a2c9d49653397546350 |
Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Resident of Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Dilogo, I.H., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prabowo, I., Resident of Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Unstable pelvic fracture may emerge to major bleeding complication. Angioembolization is one of method to stop the bleeding effectively. This case series aims to analyze whether the bleeding of unstable pelvic fracture is managed by angioembolization to achieve the better functional outcome. Presentation of case: Three cases of haemodynamically unstable pelvic fracture were studied retrospectively and prospectively. A staged approach using damage control orthopaedic surgery was performed. Initial resuscitation began from fluid resuscitation, pelvic wrapping using binder. All patients followed with pelvic external fixation, while 2 patients immediately replaced binder to C-Clamp, and 1 patient with anterior frame. Angioembolization was done to all patients. All patients required definitive internal fixation, while only 2 patients reach the definitive surgery. Finally, we measured the functional outcome of all patients using Hannover Pelvic score, Majeed pelvic score, and Iowa Pelvic score. Discussion: We review some literatures regarding pelvic angioembolization. The previous study suggested to resuscitate patients when the hemodynamic is unstable, the angioembolization procedure is still preferred. The indication and successful definition of this procedure is still unclear, yet it shows decrease of mortality rate of pelvic injury if this procedure starts ahead a schedule. Conclusion: Angioembolization as a part of damaged control orthopaedic has been shown a favorable result in managing unstable pelvic injury. © 2021 The Authors |
Angiographic embolization; Pelvic fracture; Pelvic injury |
D dimer; fibrinogen; adult; Article; artificial embolization; blood cell count; body temperature; breathing rate; case report; clinical article; female; fluid resuscitation; fracture; fracture external fixation; fracture fixation; Glasgow coma scale; heart rate; hemodynamics; hospitalization; human; lactate blood level; male; multiple trauma; orthopedics; pelvis fracture; resuscitation; systolic blood pressure; treatment response |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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