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Riset dan Pengabdian Masyarakat Do Research Sosial Service and Innovation

Id	Authors	Author S Id	Title	Year	Source Title	Volume	Issue	Art No	Page Start	Cited By	Link	Affiliations	Authors With Affiliations	Abstract	Author Keywords	Publisher	Issn	Isbn	Document Type	Sjr Best Quartile	Sjr	Sjr Rank
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471	Sampurna M.T.A., Rohsiswatmo R., Primadi A., Wandita S., Sulistijono E., Bos A.F., Sauer P.J.J., Hulzebos C.V., Dijk P.H.	57201733407;55533574600;8422152900;57194904658;57218101844;36839156800;57191375642;6603928053;6701798049;	The knowledge of Indonesian pediatric residents on hyperbilirubinemia management	2021	Heliyon	7	4	e06661			https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103706107&doi=10.1016%2fj.heliyon.2021.e06661&partnerID=40&md5=fe30c346677666133417d4195cc4b825	Neonatology Division, Department of Pediatrics, Airlangga University Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Neonatology Division, Department of Pediatrics, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatrics, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Neonatology Division, Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Pediatrics, Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands	Sampurna, M.T.A., Neonatology Division, Department of Pediatrics, Airlangga University Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Rohsiswatmo, R., Neonatology Division, Department of Pediatrics, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Primadi, A., Department of Pediatrics, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Wandita, S., Neonatology Division, Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Sulistijono, E., Department of Pediatrics, Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Bos, A.F., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Sauer, P.J.J., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Hulzebos, C.V., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Dijk, P.H., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands	Hyperbilirubinemia in the newborn occurs more frequently in Indonesia. Therefore, it is important that pediatric residents in Indonesia acquire adequate knowledge of hyperbilirubinemia management. This study aims to determine the pediatric residents' knowledge on hyperbilirubinemia management, whether they follow recommended guidelines, and whether differences exist between five large Indonesian teaching hospitals. We handed out a 25-question questionnaire on hyperbilirubinemia management to pediatric residents at five teaching hospitals. A total of 250 questionnaires were filled in completely, ranging from 14 to 113 respondents per hospital. Approximately 76% of the respondents used the Kramer score to recognize neonatal jaundice. Twenty-four percent correctly plotted the total serum bilirubin levels (TSB) on the phototherapy (PT) nomograms provided by the American Academy of Pediatrics (AAP) and the National Institute for Health and Care Excellence (NICE) for full-term and nearly full-term infants. Regarding preterm infants <35 weeks' gestational age, 66% of the respondents plotted TSB levels on the AAP nomogram, although this nomogram doesn't apply to this category of infants. Seventy percent of residents knew when to perform an exchange transfusion whereas 27% used a fixed bilirubin cut-off value of 20 mg/dL. Besides PT, 25% reported using additional pharmaceutical treatments, included albumin, phenobarbitone, ursodeoxycholic acid and immunoglobulins, while 47% of the respondents used sunlight therapy, as alternative treatment. The limited knowledge of the pediatric residents could be one factor for the higher incidence of severe hyperbilirubinemia and its sequelae. The limited knowledge of the residents raises doubts about the knowledge of the supervisors and the training of the residents since pediatric residents receive training from their supervisors. © 2021 The Author(s)	Guidelines; Hyperbilirubinemia; Knowledge; Newborn infants; Residents	Elsevier Ltd	24058440		Article	Q1	455	10919	View
490	Oswari H., Kresnawati W., Yani A., Handjari D.R., Alatas F.S.	12777323800;57210461975;57215433374;56160657900;57217150164;	Abdominal Injury-Induced Gastric Outlet Obstruction in Primary Hypertrophic Pyloric Stenosis in Adolescent	2021	Indian Journal of Surgery	83			264	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080887785&doi=10.1007%2fs12262-020-02097-y&partnerID=40&md5=341dca515f2fe3bdfc0a38dee8ba2ddb	Department of Child Health, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Department of Pediatric Surgery, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathology Anatomy, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Oswari, H., Department of Child Health, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Kresnawati, W., Department of Child Health, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Yani, A., Department of Pediatric Surgery, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Handjari, D.R., Department of Pathology Anatomy, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Alatas, F.S., Department of Child Health, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia	[No abstract available]		Springer	09722068		Letter	Q4	183	20483	View
495	Nadhif M.H., Assyarify H., Irsyad M., Pramesti A.R., Suhaeri M.	57189057498;57220927630;57220935587;57222624921;56183087500;	Recent advances in 3D printed wound dressings	2021	AIP Conference Proceedings	2344		020021		1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103522380&doi=10.1063%2f5.0047183&partnerID=40&md5=494f3e384ff38d4974127c234d704499	Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Unit of Education, Research, and Training, Universitas Indonesia Hospital, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia	Nadhif, M.H., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Assyarify, H., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Irsyad, M., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Pramesti, A.R., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Suhaeri, M., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Unit of Education, Research, and Training, Universitas Indonesia Hospital, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia	Chronic and acute wounds interfere with personal aesthetics and appearance. Regarding the problematics, researchers enhance the functionalities of wound dressings. One of the enhancement approaches is using 3D printing technology. The use of 3D printing has enabled many types of wound dressings, including biodegradable multi-material, cell-laden, and drug-eluting wound dressings. The use of 3D printing even allows for a wound dressing with a 3D construct, facilitating the wound dressing placement at the wound bed. Unfortunately, the 3D printed wound dressing technology has never been reviewed, to the extent of our knowledge. In this report, we aim to reflect on the recent advances in 3D printed wound dressings. Reports regarding the 3D printed wound dressing were collected from the Google Scholar database. The search was limited from 2015 to 2020 with a logic search: "3D printed"AND "wound dressing,"which words can be found in the entire article. Irrelevant reports were excluded manually, thereby resulting in the 24 selected articles. The selected articles were subsequently reviewed in terms of the materials-efficacy analysis and 3D printing mechanism. The extracted information from all articles concluded that alginate is the most used material for 3D printed wound dressing, while the most used 3D printing mechanism is the pneumatic FDM. In terms of efficacy, wound dressings presented an antimicrobial performance against Gram-positive and Gram-negative bacteria, as well as biocompatibility to epidermis and dermis cells. © 2021 Author(s).		American Institute of Physics Inc.	0094243X	9780735440869	Conference Paper	-	177	20880	View
496	Utomo M.S., Asmaria T., Malau D.P., Triwardono J., Kartika I., Dilogo I.H., Rahyussalim A.J.	56180933900;57212340647;57208306899;57214135764;57218158170;56161962800;55212166100;	Design criteria for cementless total hip arthroplasty: A retrospective study from cadaver implantation	2021	AIP Conference Proceedings	2344		020019			https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103521074&doi=10.1063%2f5.0047288&partnerID=40&md5=d88d2b334a37cee012b14dd1543e1689	Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Department of Orthopedics and Traumatology, RSUPN Cipto Mangunkusumo, Jl. Diponegoro No. 71, Salemba, Jakarta, 10430, Indonesia	Utomo, M.S., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Asmaria, T., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Malau, D.P., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Triwardono, J., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Kartika, I., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Dilogo, I.H., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Department of Orthopedics and Traumatology, RSUPN Cipto Mangunkusumo, Jl. Diponegoro No. 71, Salemba, Jakarta, 10430, Indonesia; Rahyussalim, A.J., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Department of Orthopedics and Traumatology, RSUPN Cipto Mangunkusumo, Jl. Diponegoro No. 71, Salemba, Jakarta, 10430, Indonesia	Total hip arthroplasty (THA) is the most frequent arthroplasty procedure performed worldwide including in Indonesia. To support Indonesian government initiative to establish a generic domestic THA implant, Research Center for Metallurgy and Materials - Indonesian Institute of Sciences in cooperation with Universitas Indonesia has designed and realized set of cementless titanium-based THA implant. Here we reported the result of first cadaver implantation for cementless titanium-based THA implant in Indonesia. There are three sets of cementless titanium-based THA implants implanted into the left leg of three cadavers. Implantation was performed simultaneously by three groups of orthopedic surgeons. There are three major aspects as evaluation from the cadaver implantation: design, material, and instrumentation. The current cementless titanium-based THA implant was designed based on the same template, material specification, process, and implanted using standard commercial instrumentation. As further directives, it is required to develop the cementless titanium-based THA implants with various shape and sizing in regard of Indonesia domestic requirement, appropriate coating for cementless implantation, refined material properties to facilitate the fabrication process, and customized instrumentation as a whole set of development within the development of the cementless titanium-based THA implant. © 2021 Author(s).		American Institute of Physics Inc.	0094243X	9780735440869	Conference Paper	-	177	20880	View
497	Utomo M.S., Nadhif M.H., Bayani G.F.E., Whulanza Y.	56180933900;57189057498;57222627409;36807053500;	A low cost, off-the-shelf bioreactor as enabling technology for physiological modeling	2021	AIP Conference Proceedings	2344		050017			https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103516555&doi=10.1063%2f5.0047233&partnerID=40&md5=321c75b01f581669d0c6f955fe9b2966	Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Department of Physiology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia	Utomo, M.S., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Nadhif, M.H., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Bayani, G.F.E., Department of Physiology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Whulanza, Y., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia	Nowadays, tissue engineering has become a primary option for clinical treatment involving tissue damage or organ failure. One important enabling technological aspect for tissue engineering to produce successful outcomes is bioreactor where cells could be grown under certain conditions mimicking real physiological conditions and be prepared for in vivo integration before implantation to the patients. Physical stimulation by mechanical and electrical means could improve the development of engineered tissue to mimic the actual tissue. Mechanical stimulation could improve cellular function by improving the integrity and organization of the engineered tissue while electrical stimulation can improve the conductivity and contractility of tissue construction. The electric field would stimulate cellular calcium activity which could stimulate cell integration and gap junction formation. Thus, it is necessary to develop a bioreactor that is capable to provide a well-controlled environment and proper combination of mechanical and electrical stimulation to optimize the process of tissue engineering. Here we build a bioreactor that is capable to stimulate the engineered tissue mechanically and electrically to improve the tissue's contractile performance and functional maturity through an isovolumic contraction. The mechanical stimulation is generated by harmonic inflation and deflation of a balloon while the electrical stimulation is generated from a pair of carbon electrodes. The mechanical and electrical stimulations could function independently to each other. The bioreactor was successfully constructed and passed the functional test and ready for actual application for tissue engineering. © 2021 Author(s).		American Institute of Physics Inc.	0094243X	9780735440869	Conference Paper	-	177	20880	View
498	Supriadi S., Rachman P., Saragih A.S., Whulanza Y., Rahyussalim A.J., Triwidodo A.	16040272500;57222619791;24339579800;36807053500;55212166100;57222626174;	Design, development, and finite element study on the novel biomimetic lumbosacroiliac prosthesis	2021	AIP Conference Proceedings	2344		050021		5	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103512681&doi=10.1063%2f5.0047182&partnerID=40&md5=ceda670f69efa9020569efb213e95b5e	Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10320, Indonesia	Supriadi, S., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Rachman, P., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Saragih, A.S., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Whulanza, Y., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Rahyussalim, A.J., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10320, Indonesia; Triwidodo, A., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10320, Indonesia	This study focused on the design of specific prostheses in the case of patients affected by Chordoma of the lumbar 4, lumbar 5, sacrum, and coccyx. A chordoma is a group of malignant and rare cancers, commonly found in the spine or skull bones. As a treatment method, if cancer has not spread beyond the bone, the infected bone's removal procedure is replaced with an artificial bone (prosthesis). The design method is carried out using a CT Scan of patient data, which is processed into a 3D model with Materialise Mimics software, 3D model engineering is done using Solidworks software and finite element analysis with ANSYS. The design process is carried out with several kinds of design variations, including the bone-implant model with a solid and shell model which is divided into several components, the use of iliac screw lateral connector, modification of iliac screw locking head, and modification of iliac screw locking head with cross connector. From the results of the calculation analysis and simulation, the best concept chosen based on the lowest dominant Peak von Mises Stress value in the iliac screw section is designs using the Iliac Screw Locking Head with Shell Model Lattice Structure. © 2021 Author(s).	3d bone modeling; Chordoma; lumbar; pedicle screw; prosthesis; pull out; sacrum; simulation	American Institute of Physics Inc.	0094243X	9780735440869	Conference Paper	-	177	20880	View
499	Pangjaya L.F., Khaerunnisa S., Mazfufah N.F., Budiman R.L., Antarianto R.D.	57222624829;57221948155;57215595521;57222627263;57190862806;	Investigating different type of ovary cancer cell line for NK cell in vitro co-culture cytotoxic assay	2021	AIP Conference Proceedings	2344		040010			https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103511346&doi=10.1063%2f5.0049155&partnerID=40&md5=34e5a053702d387eeb6890faa2868915	Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia	Pangjaya, L.F., Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Khaerunnisa, S., Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Mazfufah, N.F., Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Budiman, R.L., Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Antarianto, R.D., Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia, Department of Histology, Faculty of Medicine, Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia	Ovarian cancer is one of the gynecologic cancers with a high mortality rate and increased incidence. Surgery and therapies are used to treat ovarian cancer patients. Therapies such as chemotherapy and radiotherapy can cause resistance therefore immunotherapy using natural killer (NK) cells can be an alternative therapy. NK cells have shown an important role in anticancer activity because it is able to kill target cells without prior sensitization and can acquire immunology memory. However, NK cells as immunotherapy have low capacity and efficacy on infiltrating ovarian cancer's tumor microenvironment. To overcome these NK cells need to be induced with certain antigen resulting in enhanced NK cells. Enhanced NK cells display a higher cytotoxic activity that can be seen by co-culturing enhanced NK cells with ovarian cancer cell lines. In this mini-review, the selection of ovarian cancer cell lines was displayed to offer reliable consideration to obtain the expected research endpoint. © 2021 Author(s).	co-culture; cytotoxic assay; NK cells; ovarian cancer; ovarian cancer cell lines	American Institute of Physics Inc.	0094243X	9780735440869	Conference Paper	-	177	20880	View
500	Hartanto J., Purwaningsih E.H., Krisnamurti D.G.B.	57222620672;57186723500;55934951600;	Administration of Centella asiatica ethanolic extract reduces tumor necrosis factor-alpha in hearts of aged sprague-dawley rats but not kidneys	2021	AIP Conference Proceedings	2344		040012			https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103510292&doi=10.1063%2f5.0048269&partnerID=40&md5=5a0382b6ee463f35130ebe47cde75fd1	Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Jakarta, 10430, Indonesia; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Jakarta, 10430, Indonesia; Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Jakarta, 10430, Indonesia	Hartanto, J., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Jakarta, 10430, Indonesia; Purwaningsih, E.H., Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Jakarta, 10430, Indonesia, Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Jakarta, 10430, Indonesia; Krisnamurti, D.G.B., Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Jakarta, 10430, Indonesia, Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Jakarta, 10430, Indonesia	Aging is a time-related process leading to progressive deterioration of physiological bodily functions and increased vulnerability to degenerative disorders. The current trend of rapid growth in the global aging population poses a challenge for healthcare due to the increasing incidence of chronic diseases. In spite of this, preventive anti-aging agents such as vitamin supplements are not adequately available in many countries. Centella asiatica (CA), a traditional herb native to Southeast Asia, has been widely studied and demonstrated potent anti-inflammatory, antioxidant, neuroprotective, wound healing, and vasculoprotective effects in clinical studies. This study investigates the effect of CA treatment on aged Sprague-Dawley (SD) rats. Twenty-four rats were divided into four groups: positive control (vitamin E 6 IU), negative control (placebo), treatment group (CA 300 mg/kgBW), and comparison group (young SD rats with placebo). After 28 days of treatment, SD rats were terminated. TNF-a concentration in heart and kidney tissues were determined using enzyme-linked immunosorbent assay. We found that CA showed a significant decrease in heart TNF-alpha (p = 0.021) yet yields no statistically significant decrease in kidney TNF-alpha levels (p = 0.617). However, it was possible to identify a trend toward decreasing kidney TNF-a concentration in groups treated with CA as it was lower than the positive and negative control group. Our finding suggests different aging pathophysiology in different body organs and CA's potential as an anti-aging agent, corresponding to previous studies showing potent anti-inflammatory effects of CA in multiple organs. All in all, further research and exploration need to be made on aging pathophysiology and CA with variations of a more significant dose and longer time of administration. © 2021 Author(s).	aging; Centella asiatica; oxidative stress; tumor necrosis factor-alpha	American Institute of Physics Inc.	0094243X	9780735440869	Conference Paper	-	177	20880	View
501	Sutanto R.L., Purwaningsih E.H., Krisnamurti D.G.B.	57222060277;57186723500;55934951600;	Antiaging effects of Acalypha indica L. extract administration on tumor necrosis factor-a (TNF-a) protein level in major organs of aged Sprague-Dawley rats	2021	AIP Conference Proceedings	2344		040011			https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103498448&doi=10.1063%2f5.0048267&partnerID=40&md5=0c80797e53b938c80ec492fb2905bba1	Undergraduate Student, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia	Sutanto, R.L., Undergraduate Student, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Purwaningsih, E.H., Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia, Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Krisnamurti, D.G.B., Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia, Drug Development Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia	Non-communicable diseases, such as cardiovascular diseases or kidney dysfunctions, tend to have expensive and unavailable treatments. This fact, coupled with the rising trend of such diseases, means that priority should be given towards preventive measures. One such measure is the administration of antioxidants to counter the increasing inflammatory markers, such as TNF-a, in the pathogenesis of chronic non-communicable diseases. However, the usage of synthetic antioxidants chronically may incur side effects and expensive. Indonesia is home to diverse sorts of vegetations as an agricultural power, such as Acalypha indica L. (AI). AI has been used empirically by cultures across the globe and is found to have antioxidant properties. This study was conducted on aged Sprague-Dawley rats. Rats were divided into four groups, the negative control (placebo), positive control using 6 IU vitamin E, treatment group using 250 mg/kg of body weight (mg/kg BW) AI extract, and control using young rats. The rats were then terminated after 28 days, and the major organs, kidneys, and hearts were examined using ELISA to look for TNF-a concentration. Data collected were analyzed using Saphiro-Wilk test and one-way ANOVA. AI administration yielded a decrease of TNF-a in both the kidneys (0.95 ± 0.76 pg/mg in the treatment group vs. 1.37 ± 0.41 pg/mg in the negative control) and hearts (15.43 pg/mg ± 2.33 in the treatment group vs. 16.50 ± 1.33 pg/mg in the negative control), of aged SD rats, albeit insignificantly. A relatively short time of treatment in this study could be attributed to the insignificant decrease in kidney and cardiac tissue. Nevertheless, this finding of decreased TNF-a suggests a potential anti-inflammatory and antiaging effect of AI. Further research suggestions on the investigation of AI are using longer time of treatment and other test subjects. © 2021 Author(s).	Acalypha indica; Aging; heart; kidney; TNF-a	American Institute of Physics Inc.	0094243X	9780735440869	Conference Paper	-	177	20880	View
502	Zakaria H., Setiawan R., Mayza A.	24465810100;57210969274;57211585788;	Analysis of quantitative EEG (QEEG) parameters on post-stroke patients undergoing static bicycle and mirror combination therapy	2021	AIP Conference Proceedings	2344		050006			https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103495833&doi=10.1063%2f5.0047217&partnerID=40&md5=194ec9233261b2f6297da53ee96182d2	School of Electrical Engineering and Informatics, Bandung Institute of Technology (ITB), Ganesa 10, Bandung, West Java, 40119, Indonesia; Neurology Department and Cluster of Medical Technology IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Central Jakarta, 10430, Indonesia	Zakaria, H., School of Electrical Engineering and Informatics, Bandung Institute of Technology (ITB), Ganesa 10, Bandung, West Java, 40119, Indonesia; Setiawan, R., School of Electrical Engineering and Informatics, Bandung Institute of Technology (ITB), Ganesa 10, Bandung, West Java, 40119, Indonesia; Mayza, A., School of Electrical Engineering and Informatics, Bandung Institute of Technology (ITB), Ganesa 10, Bandung, West Java, 40119, Indonesia, Neurology Department and Cluster of Medical Technology IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No 6, Central Jakarta, 10430, Indonesia	Stroke causes neurological disorders such as reduced muscle motor skills, as well as cognitive, visual, and coordination functions, significantly. The reduced level of independence and mobility of a person can affect their quality of life. Previous research used static bicycles or mirrors for stroke therapy. This work combined both static bicycle and mirror therapy for post-stroke patients. This study aimed to find quantitative EEG parameters that can be used to characterize neurological change. The expected decrease in the average relative power of delta and theta then increased alpha and beta. Twelve post-stroke patients and twelve healthy subjects were given 2 tasks: imaginary (motor imagery) and action (motor execution). The electrodes were placed on 8 points with 10-20 localization principle rules. Data were analyzed and tested using linear regression and paired t. The result showed that static bicycle and mirror combination therapy affects a subject group of right stroke patients than a subject group of left stroke patients. When given imaginary session (motor imagery), in relative power of delta-band frequency of right stroke patients decreased by -18.65 ± 4.9% (p = 0.0001) and action session (motor execution) by -11.23 ± 6.1% (p = 0.0035), while average relative power of theta frequency band only decreased significantly by -6.03 ± 6.4% (p = 0.0429) an imaginary session. Then, this therapy also succeeded in enhancement relative power of alpha frequency band when given imaginary session, i.e 5.45 ± 4.2% (p = 0.0161) and action session, i.e 6.92 ± 4.6% (p = 0.0024). Furthermore, the relative power of the beta frequency band also increased when given an imaginary session by 19.23 ± 9.1% (p = 0.0026) and action session by 7.29 ± 7.5% (p = 0.0194). In conclusion, relative power, amplitude, and time (latency) of P300 and C3 to C4 ratio indicated improved health data, especially for right stroke patient subjects during therapy. © 2021 Author(s).	Combination Therapy; Mirror; Post-Stroke Patients; QEEG; Static Bicycle	American Institute of Physics Inc.	0094243X	9780735440869	Conference Paper	-	177	20880	View

Publikasi Scopus 926 artikel (Per 14 Maret 2022)