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No records
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485 |
Simadibrata D.M., Calvin J., Wijaya A.D., Ibrahim N.A.A. |
57202134322;57221411392;57221411463;57221410260; |
Neutrophil-to-lymphocyte ratio on admission to predict the severity and mortality of COVID-19 patients: A meta-analysis |
2021 |
American Journal of Emergency Medicine |
42 |
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60 |
69 |
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22 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099401846&doi=10.1016%2fj.ajem.2021.01.006&partnerID=40&md5=9764e041c3a47b836e3ffc766efdf406 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Simadibrata, D.M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Calvin, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wijaya, A.D., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ibrahim, N.A.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: The neutrophil-to-lymphocyte ratio (NLR), an inflammatory marker, was suggested to be predictive of severity and mortality in COVID-19 patients. Here, we investigated whether NLR levels on admission could predict the severity and mortality of COVID-19 patients. Methods: A literature search was conducted on 23 July 2020 to retrieve all published articles, including grey literature and preprints, investigating the association between on-admission NLR values and severity or mortality in COVID-19 patients. A meta-analysis was performed to determine the overall standardized mean difference (SMD) in NLR values and the pooled risk ratio (RR) for severity and mortality with the 95% Confidence Interval (95%CI). Results: A total of 38 articles, including 5699 patients with severity outcomes and 6033 patients with mortality outcomes, were included. The meta-analysis showed that severe and non-survivors of COVID-19 had higher on-admission NLR levels than non-severe and survivors (SMD 0.88; 95%CI 0.72–1.04; I2 = 75.52% and 1.87; 95%CI 1.25–2.49; I2 = 97.81%, respectively). Regardless of the different NLR cut-off values, the pooled mortality RR in patients with elevated vs. normal NLR levels was 2.74 (95%CI 0.98–7.66). Conclusion: High NLR levels on admission were associated with severe COVID-19 and mortality. Further studies need to focus on determining the optimal cut-off value for NLR before clinical use. © 2021 Elsevier Inc. |
COVID-19; Meta-analysis; Mortality; Neutrophil-to-lymphocyte ratio; Severity |
Article; coronavirus disease 2019; disease association; disease severity; hospital admission; human; meta analysis; mortality; mortality risk; neutrophil lymphocyte ratio; outcome assessment; prediction; priority journal; quality control; risk assessment; sensitivity and specificity; sex ratio; survivor; systematic review; blood; diagnosis; hospitalization; lymphocyte count; neutrophil; severity of illness index; survival rate; COVID-19; Hospitalization; Humans; Lymphocyte Count; Neutrophils; Severity of Illness Index; Survival Rate |
W.B. Saunders |
07356757 |
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33453617 |
Article |
Q1 |
725 |
6828 |
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488 |
Djaja Y.P., Prasetia R., Santoso A., Rahyussalim A.J., Mustamsir E., Dilogo I.H. |
57191042059;57196246350;57194659467;55212166100;57196246488;56161962800; |
A decade of evolution in Indonesian orthopedic publication: A bibliographic report |
2021 |
Journal of Clinical Orthopaedics and Trauma |
15 |
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110 |
116 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092623352&doi=10.1016%2fj.jcot.2020.10.016&partnerID=40&md5=54bca8c1ea47f4019dfac052838cc471 |
Department of Orthopedic & Traumatology, Fatmawati General Hospital, Jakarta, Indonesia; Faculty of Medicine, Department of Orthopaedic Surgery, Universitas Padjadjaran, Bandung, Indonesia; Department of Orthopaedic and Traumatology, Sebelas Maret University, Prof Dr R Soeharso Orthopaedic Hospital, Solo, Indonesia; Department of Orthopaedic & Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia |
Djaja, Y.P., Department of Orthopedic & Traumatology, Fatmawati General Hospital, Jakarta, Indonesia; Prasetia, R., Faculty of Medicine, Department of Orthopaedic Surgery, Universitas Padjadjaran, Bandung, Indonesia; Santoso, A., Department of Orthopaedic and Traumatology, Sebelas Maret University, Prof Dr R Soeharso Orthopaedic Hospital, Solo, Indonesia; Rahyussalim, A.J., Department of Orthopaedic & Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Mustamsir, E., Department of Orthopaedics and Traumatology, Faculty of Medicine Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia; Dilogo, I.H., Department of Orthopaedic & Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
During the past decade, there was an increasing interest in orthopedic research in Indonesia. Therefore we aimed to investigate the profile of Indonesian orthopedic trend publication from 2010 to 2019. Systematic research was conducted to identify all orthopedic articles authored by Indonesian orthopedic surgeons. Article details (number of authors, authors’ affiliation, publishing journal), type of author's affiliation, affiliate collaboration, study field, type, and level of evidence (LOE) were recorded and evaluated. Publishing journal metric and author h-index were also recorded. Descriptive statistics were used to summarize the data. Two hundred and twenty articles were included in our study. Clinical studies were the most common article type, followed by case reports and basic science. Among clinical articles, therapeutic studies were found significantly more frequent. On the other hand, economic studies were not found in this study period. The most popular field was oncology, followed by knee and spine. The average number of authors per article was 5.23 with a total of 205 individuals who had contributed during this decade. University hospital was the most common affiliation found and single-center study was the most common affiliate collaboration. The most common level of evidence was level V (case reports). Eighty-seven specific publishing journals were identified. More than 42% of the articles were published in journals with SJR between 0.25 and 0.50. The average author h-index was 3.56 (0–7). Although there was an increasing trend and quantity of publications among Indonesian authors, most articles had level 5 evidence (case reports) and the quality of publishing journals was mostly Q3 with a low-moderate SJR. Improvement of the article's quality and institutional collaboration will be needed for future contribution in global orthopedic society. © 2020 Delhi Orthopedic Association |
Bibliographic; Indonesia; Orthopedic article; Publication trend |
adult; female; human; human experiment; Indonesia; knee; major clinical study; male; orthopedic surgeon; publishing; review; spine; university hospital |
Elsevier B.V. |
09765662 |
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Review |
Q3 |
471 |
10597 |
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489 |
Pranata R., Tondas A.E., Huang I., Lim M.A., Siswanto B.B., Meyer M., Mitrovic V. |
57201973901;57211111907;57208576645;57216039756;14422648800;57217373886;36008843300; |
Potential role of telemedicine in solving ST-segment elevation dilemmas in remote areas during the COVID-19 pandemic |
2021 |
American Journal of Emergency Medicine |
42 |
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242 |
243 |
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10 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086651966&doi=10.1016%2fj.ajem.2020.06.012&partnerID=40&md5=c3d261a0e2fe3a8f2757142babbe0759 |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Department of Cardiology and Vascular Medicine, Mohammad Hoesin General Hospital, Palembang, Sumatera Selatan, Indonesia; Biomedicine Doctoral Program, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas, Jakarta, Indonesia; Department of Cardiology, Kerckhoff-Klinik, Bad Nauheim, Germany |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Tondas, A.E., Department of Cardiology and Vascular Medicine, Mohammad Hoesin General Hospital, Palembang, Sumatera Selatan, Indonesia, Biomedicine Doctoral Program, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; Huang, I., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Siswanto, B.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Meyer, M., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas, Jakarta, Indonesia; Mitrovic, V., Department of Cardiology, Kerckhoff-Klinik, Bad Nauheim, Germany |
[No abstract available] |
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troponin; acute coronary syndrome; blood clot lysis; cardiologist; cardiovascular risk; coronavirus disease 2019; echocardiography; electrocardiography; heart ventricle wall motion; human; incidence; Letter; myocarditis; pandemic; practice guideline; priority journal; risk factor; ST segment elevation; ST segment elevation myocardial infarction; takotsubo cardiomyopathy; telecardiology; telemedicine; epidemiology; health care delivery; organization and management; prevention and control; rural health care; ST segment elevation myocardial infarction; telemedicine; COVID-19; Health Services Accessibility; Humans; Rural Health Services; ST Elevation Myocardial Infarction; Telemedicine |
W.B. Saunders |
07356757 |
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32561139 |
Letter |
Q1 |
725 |
6828 |
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490 |
Oswari H., Kresnawati W., Yani A., Handjari D.R., Alatas F.S. |
12777323800;57210461975;57215433374;56160657900;57217150164; |
Abdominal Injury-Induced Gastric Outlet Obstruction in Primary Hypertrophic Pyloric Stenosis in Adolescent |
2021 |
Indian Journal of Surgery |
83 |
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264 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080887785&doi=10.1007%2fs12262-020-02097-y&partnerID=40&md5=341dca515f2fe3bdfc0a38dee8ba2ddb |
Department of Child Health, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Department of Pediatric Surgery, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathology Anatomy, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Oswari, H., Department of Child Health, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Kresnawati, W., Department of Child Health, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Yani, A., Department of Pediatric Surgery, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Handjari, D.R., Department of Pathology Anatomy, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Alatas, F.S., Department of Child Health, Cipto Mangunkusumo Hospital-Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia |
[No abstract available] |
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Springer |
09722068 |
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Letter |
Q4 |
183 |
20483 |
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494 |
Turu' Allo I.J., Santoso A., Findyartini A. |
57222645159;36905206100;56543777300; |
Cardiology trainees' attitudes towards clinical supervision: a scale development study |
2021 |
International journal of medical education |
12 |
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38 |
44 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103608400&doi=10.5116%2fijme.604a.4964&partnerID=40&md5=d05fe194366331389db166e4ab3e2b62 |
Medical Education Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Department of Cardiology-Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Centre-Harapan Kita HospitalJakarta, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Turu' Allo, I.J., Medical Education Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Santoso, A., Department of Cardiology-Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Centre-Harapan Kita HospitalJakarta, Indonesia; Findyartini, A., Department of Medical Education, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Objectives: This study aims to explore the construct validity, dimensionality, and internal consistency of a new attitude scale for measuring cardiology trainees' attitudes towards clinical supervision. Methods: A multi-centred, cross-sectional study involving 388 Indonesian cardiology trainees from eight universities was conducted using convenience sampling. Twenty-nine items have been generated based on an extensive literature review and conceptual framework of effective clinical supervision. Ten clinical experts reviewed the items to ensure the Cardiology Clinical Supervision Scale (CCSS) adequately represents the construct under study. An exploratory factor analysis using principal axis factoring (PAF) with oblique rotation was run to identify the internal structure of the scale. Items with factor loading <0.50 were deleted. In addition, inter-item correlations and items' communalities were analysed. Each subscale's internal consistency was assessed using Cronbach's alpha score. Results: The content validity index provided evidence for CCSS' validity (G-coefficient=0.71). Scrutinising the experts' comments, we finalised the scale to include 27 items. Further, four items were deleted due to low inter-item correlation and communality. PAF analysis resulted in a two-factor model comprising the "Supervisory Interaction and Facilitation" factor (n=10 items) and the "Role Modelling" factor (n=9 items); four items were deleted due to low factor loading. The Cronbach's alpha score for SIF and RM factors were 0.93 and 0.89, respectively. Conclusions: The study's results support the validity, internal structure, and internal consistency of the new clinical supervision scale for cardiology training. Further studies are required to investigate other validity and reliability evidence for CCSS, including its cross-cultural validity. |
cardiology training; clinical supervision; scale development |
attitude; cardiology; cross-sectional study; human; psychometry; questionnaire; reproducibility; Attitude; Cardiology; Cross-Sectional Studies; Humans; Psychometrics; Reproducibility of Results; Surveys and Questionnaires |
NLM (Medline) |
20426372 |
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33772563 |
Article |
Q2 |
592 |
8541 |
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495 |
Nadhif M.H., Assyarify H., Irsyad M., Pramesti A.R., Suhaeri M. |
57189057498;57220927630;57220935587;57222624921;56183087500; |
Recent advances in 3D printed wound dressings |
2021 |
AIP Conference Proceedings |
2344 |
|
020021 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103522380&doi=10.1063%2f5.0047183&partnerID=40&md5=494f3e384ff38d4974127c234d704499 |
Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Unit of Education, Research, and Training, Universitas Indonesia Hospital, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia |
Nadhif, M.H., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Assyarify, H., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Irsyad, M., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Pramesti, A.R., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Suhaeri, M., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Unit of Education, Research, and Training, Universitas Indonesia Hospital, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia |
Chronic and acute wounds interfere with personal aesthetics and appearance. Regarding the problematics, researchers enhance the functionalities of wound dressings. One of the enhancement approaches is using 3D printing technology. The use of 3D printing has enabled many types of wound dressings, including biodegradable multi-material, cell-laden, and drug-eluting wound dressings. The use of 3D printing even allows for a wound dressing with a 3D construct, facilitating the wound dressing placement at the wound bed. Unfortunately, the 3D printed wound dressing technology has never been reviewed, to the extent of our knowledge. In this report, we aim to reflect on the recent advances in 3D printed wound dressings. Reports regarding the 3D printed wound dressing were collected from the Google Scholar database. The search was limited from 2015 to 2020 with a logic search: "3D printed"AND "wound dressing,"which words can be found in the entire article. Irrelevant reports were excluded manually, thereby resulting in the 24 selected articles. The selected articles were subsequently reviewed in terms of the materials-efficacy analysis and 3D printing mechanism. The extracted information from all articles concluded that alginate is the most used material for 3D printed wound dressing, while the most used 3D printing mechanism is the pneumatic FDM. In terms of efficacy, wound dressings presented an antimicrobial performance against Gram-positive and Gram-negative bacteria, as well as biocompatibility to epidermis and dermis cells. © 2021 Author(s). |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
- |
177 |
20880 |
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496 |
Utomo M.S., Asmaria T., Malau D.P., Triwardono J., Kartika I., Dilogo I.H., Rahyussalim A.J. |
56180933900;57212340647;57208306899;57214135764;57218158170;56161962800;55212166100; |
Design criteria for cementless total hip arthroplasty: A retrospective study from cadaver implantation |
2021 |
AIP Conference Proceedings |
2344 |
|
020019 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103521074&doi=10.1063%2f5.0047288&partnerID=40&md5=d88d2b334a37cee012b14dd1543e1689 |
Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Department of Orthopedics and Traumatology, RSUPN Cipto Mangunkusumo, Jl. Diponegoro No. 71, Salemba, Jakarta, 10430, Indonesia |
Utomo, M.S., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Asmaria, T., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Malau, D.P., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Triwardono, J., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Kartika, I., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Dilogo, I.H., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Department of Orthopedics and Traumatology, RSUPN Cipto Mangunkusumo, Jl. Diponegoro No. 71, Salemba, Jakarta, 10430, Indonesia; Rahyussalim, A.J., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Department of Orthopedics and Traumatology, RSUPN Cipto Mangunkusumo, Jl. Diponegoro No. 71, Salemba, Jakarta, 10430, Indonesia |
Total hip arthroplasty (THA) is the most frequent arthroplasty procedure performed worldwide including in Indonesia. To support Indonesian government initiative to establish a generic domestic THA implant, Research Center for Metallurgy and Materials - Indonesian Institute of Sciences in cooperation with Universitas Indonesia has designed and realized set of cementless titanium-based THA implant. Here we reported the result of first cadaver implantation for cementless titanium-based THA implant in Indonesia. There are three sets of cementless titanium-based THA implants implanted into the left leg of three cadavers. Implantation was performed simultaneously by three groups of orthopedic surgeons. There are three major aspects as evaluation from the cadaver implantation: design, material, and instrumentation. The current cementless titanium-based THA implant was designed based on the same template, material specification, process, and implanted using standard commercial instrumentation. As further directives, it is required to develop the cementless titanium-based THA implants with various shape and sizing in regard of Indonesia domestic requirement, appropriate coating for cementless implantation, refined material properties to facilitate the fabrication process, and customized instrumentation as a whole set of development within the development of the cementless titanium-based THA implant. © 2021 Author(s). |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
- |
177 |
20880 |
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497 |
Utomo M.S., Nadhif M.H., Bayani G.F.E., Whulanza Y. |
56180933900;57189057498;57222627409;36807053500; |
A low cost, off-the-shelf bioreactor as enabling technology for physiological modeling |
2021 |
AIP Conference Proceedings |
2344 |
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050017 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103516555&doi=10.1063%2f5.0047233&partnerID=40&md5=321c75b01f581669d0c6f955fe9b2966 |
Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Department of Physiology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia |
Utomo, M.S., Research Center for Metallurgy and Materials, Indonesian Institute of Sciences, PUSPIPTEK Area, 470 South Tangerang, Banten, 15314, Indonesia; Nadhif, M.H., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Bayani, G.F.E., Department of Physiology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, DKI Jakarta, 10430, Indonesia; Whulanza, Y., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia |
Nowadays, tissue engineering has become a primary option for clinical treatment involving tissue damage or organ failure. One important enabling technological aspect for tissue engineering to produce successful outcomes is bioreactor where cells could be grown under certain conditions mimicking real physiological conditions and be prepared for in vivo integration before implantation to the patients. Physical stimulation by mechanical and electrical means could improve the development of engineered tissue to mimic the actual tissue. Mechanical stimulation could improve cellular function by improving the integrity and organization of the engineered tissue while electrical stimulation can improve the conductivity and contractility of tissue construction. The electric field would stimulate cellular calcium activity which could stimulate cell integration and gap junction formation. Thus, it is necessary to develop a bioreactor that is capable to provide a well-controlled environment and proper combination of mechanical and electrical stimulation to optimize the process of tissue engineering. Here we build a bioreactor that is capable to stimulate the engineered tissue mechanically and electrically to improve the tissue's contractile performance and functional maturity through an isovolumic contraction. The mechanical stimulation is generated by harmonic inflation and deflation of a balloon while the electrical stimulation is generated from a pair of carbon electrodes. The mechanical and electrical stimulations could function independently to each other. The bioreactor was successfully constructed and passed the functional test and ready for actual application for tissue engineering. © 2021 Author(s). |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
|
Conference Paper |
- |
177 |
20880 |
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498 |
Supriadi S., Rachman P., Saragih A.S., Whulanza Y., Rahyussalim A.J., Triwidodo A. |
16040272500;57222619791;24339579800;36807053500;55212166100;57222626174; |
Design, development, and finite element study on the novel biomimetic lumbosacroiliac prosthesis |
2021 |
AIP Conference Proceedings |
2344 |
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050021 |
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5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103512681&doi=10.1063%2f5.0047182&partnerID=40&md5=ceda670f69efa9020569efb213e95b5e |
Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10320, Indonesia |
Supriadi, S., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Rachman, P., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Saragih, A.S., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Whulanza, Y., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Research Center for Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Rahyussalim, A.J., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10320, Indonesia; Triwidodo, A., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10320, Indonesia |
This study focused on the design of specific prostheses in the case of patients affected by Chordoma of the lumbar 4, lumbar 5, sacrum, and coccyx. A chordoma is a group of malignant and rare cancers, commonly found in the spine or skull bones. As a treatment method, if cancer has not spread beyond the bone, the infected bone's removal procedure is replaced with an artificial bone (prosthesis). The design method is carried out using a CT Scan of patient data, which is processed into a 3D model with Materialise Mimics software, 3D model engineering is done using Solidworks software and finite element analysis with ANSYS. The design process is carried out with several kinds of design variations, including the bone-implant model with a solid and shell model which is divided into several components, the use of iliac screw lateral connector, modification of iliac screw locking head, and modification of iliac screw locking head with cross connector. From the results of the calculation analysis and simulation, the best concept chosen based on the lowest dominant Peak von Mises Stress value in the iliac screw section is designs using the Iliac Screw Locking Head with Shell Model Lattice Structure. © 2021 Author(s). |
3d bone modeling; Chordoma; lumbar; pedicle screw; prosthesis; pull out; sacrum; simulation |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
- |
177 |
20880 |
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499 |
Pangjaya L.F., Khaerunnisa S., Mazfufah N.F., Budiman R.L., Antarianto R.D. |
57222624829;57221948155;57215595521;57222627263;57190862806; |
Investigating different type of ovary cancer cell line for NK cell in vitro co-culture cytotoxic assay |
2021 |
AIP Conference Proceedings |
2344 |
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040010 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103511346&doi=10.1063%2f5.0049155&partnerID=40&md5=34e5a053702d387eeb6890faa2868915 |
Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia |
Pangjaya, L.F., Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Khaerunnisa, S., Biology Undergraduate Program, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Mazfufah, N.F., Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Budiman, R.L., Department of Biology, Faculty of Mathematics and Natural Science, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Antarianto, R.D., Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia, Department of Histology, Faculty of Medicine, Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia |
Ovarian cancer is one of the gynecologic cancers with a high mortality rate and increased incidence. Surgery and therapies are used to treat ovarian cancer patients. Therapies such as chemotherapy and radiotherapy can cause resistance therefore immunotherapy using natural killer (NK) cells can be an alternative therapy. NK cells have shown an important role in anticancer activity because it is able to kill target cells without prior sensitization and can acquire immunology memory. However, NK cells as immunotherapy have low capacity and efficacy on infiltrating ovarian cancer's tumor microenvironment. To overcome these NK cells need to be induced with certain antigen resulting in enhanced NK cells. Enhanced NK cells display a higher cytotoxic activity that can be seen by co-culturing enhanced NK cells with ovarian cancer cell lines. In this mini-review, the selection of ovarian cancer cell lines was displayed to offer reliable consideration to obtain the expected research endpoint. © 2021 Author(s). |
co-culture; cytotoxic assay; NK cells; ovarian cancer; ovarian cancer cell lines |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
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177 |
20880 |
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