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302 |
Menaldi S.L., Dinakrisma A.A., Thio H.B., Rengganis I., Oktaria S. |
57192918198;57208817505;6603706049;8449988000;57189897691; |
Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection |
2021 |
PLoS Neglected Tropical Diseases |
15 |
7 |
e0009453 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112233539&doi=10.1371%2fjournal.pntd.0009453&partnerID=40&md5=ca1861c9fbca4ae66dbabcdc89952023 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Dermatology, Erasmus University Medical Center, Rotterdam, Netherlands |
Menaldi, S.L., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dinakrisma, A.A., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Thio, H.B., Department of Dermatology, Erasmus University Medical Center, Rotterdam, Netherlands; Rengganis, I., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktaria, S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Dermatology, Erasmus University Medical Center, Rotterdam, Netherlands |
AU: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly: We describe an unusual case of type 2 leprosy reaction (T2R) with septic shock–like features induced by helminth infection in a 31-year-old Moluccan male patient with a history of completed treatment of WHO multidrug therapy (MAU: PleasenotethatMDThasbeendefinedasmultidrugt DT)–multibacillary (MB) regimen 2 years before admission. During the course of illness, the patient had numerous complications, including septic shock, anemia, and disseminated intravascular coagulation (DIC). Nevertheless, antibiotic therapies failed to give significant results, and the source of infection could not be identified. Helminth infection was subsequently revealed by endoscopic examination followed by parasitological culture. Resolution of symptoms and normal level of organ function–specific markers were resolved within 3 days following anthelmintic treatment. This report demonstrated the challenge in the diagnosis and treatment of severe T2R. Given that helminth infections may trigger severe T2R that mimics septic shock, health professionals need to be aware of this clinical presentation, especially in endemic regions of both diseases. © 2021 Fongwen et al. |
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leprostatic agent; adult; animal; case report; classification; complication; genetics; helminth; helminthiasis; human; isolation and purification; leprosy; male; opportunistic infection; parasitology; sepsis; Adult; Animals; Helminthiasis; Helminths; Humans; Leprostatic Agents; Leprosy; Male; Opportunistic Infections; Sepsis |
Public Library of Science |
19352727 |
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34314436 |
Article |
Q1 |
1990 |
1322 |
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307 |
Wiguna T., Ismail R.I., Kaligis F., Minayati K., Murtani B.J., Wigantara N.A., Pradana K., Bahana R., Dirgantoro B.P., Nugroho E. |
24367785700;55996895500;36604651700;57218681686;57216652176;57218679014;57220165625;56400946100;57202082268;56493037400; |
Developing and feasibility testing of the Indonesian computer-based game prototype for children with attention deficit/hyperactivity disorder |
2021 |
Heliyon |
7 |
7 |
e07571 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110552291&doi=10.1016%2fj.heliyon.2021.e07571&partnerID=40&md5=8eca39aaa9e8ed828955cacd6838b22f |
Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Computer Science, Bina Nusantara University, Jakarta, Indonesia; Kummara Game Design Studio, Bandung, West Java, Indonesia |
Wiguna, T., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ismail, R.I., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Kaligis, F., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Minayati, K., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wigantara, N.A., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pradana, K., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Bahana, R., Department of Computer Science, Bina Nusantara University, Jakarta, Indonesia; Dirgantoro, B.P., Department of Computer Science, Bina Nusantara University, Jakarta, Indonesia; Nugroho, E., Kummara Game Design Studio, Bandung, West Java, Indonesia |
The aim of this study was to develop an Indonesian computer-based game prototype, including feasibility testing, targeted on attention deficit/hypersensitivity disorder (ADHD) clinical symptoms and executive function. The study comprised five steps. The first to third steps used an exploratory qualitative research design. The Delphi technique with FGD was applied to collect qualitative data. During the study, seven experts participated in ten FGDs. Feasibility testing was conducted as a one group pre- and post-test design that included ten children with drug-naïve ADHD without other mental or physical disorders. Feasibility data were collected before and after 20 training sessions with the Indonesian computer-based game prototype. The framework analysis was performed for qualitative data. Quantitative data were analyzed using the paired t-test, Pearson's correlation and Spearman's rank-order correlation. Outputs of the exploratory qualitative study were the Indonesian computer-based game prototype constructs and general agreements of the prototype,. The Indonesian computer-based game prototype construct comprised six components: reward-related processing, control inhibition, improved sustained attention, specific timing, increased arousal, and improved emotional regulation. After 20 sessions of training, several indicators decreased significantly, such as CATPRS-teacher rating (18.5 [5.31] vs. 12.9 [5.51], p = 0.047), BRIEF-GEC (64.80 [10.21] vs. 57.50 [7.51], p = 0.02), BRIEF-MI (66.1 [7.61] vs. 58.4 [7.56], p = 0.014), BRIEF-Initiate (66.6 [10.15] vs. 54.1 [6.49], p = 0.008), BRIEF-Working Memory (68.0 [6.89] vs. 60.9 [10.05], p = 0.02), and BRIEF-Organization of Material (60.7 [12.88] vs. 49.3 [11.79], p = 0.04). There was a low to moderate correlation between CATPRS-teacher and -parent rating and several BRIEF domains. Feasibility testing output also included the training procedure guideline. The present study indicated that the Indonesian computer-based game prototype could be used as a framework to develop a fixed computer-based game intervention for children with ADHD. However, further randomized controlled studies need to be conducted to show its effectiveness. © 2021 The Author(s) |
ADHD; Behavioral Rating Inventory for Executive Function; Computer-based game; Connors Abbreviated Teacher; Executive function; Indonesia |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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308 |
Sartika A.N., Khoirunnisa M., Meiyetriani E., Ermayani E., Pramesthi I.L., Nur Ananda A.J. |
57221416383;57226010121;57209855172;57207767542;57225987145;57225998001; |
Prenatal and postnatal determinants of stunting at age 0–11 months: A cross-sectional study in Indonesia |
2021 |
PLoS ONE |
16 |
7 July |
e0254662 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110244631&doi=10.1371%2fjournal.pone.0254662&partnerID=40&md5=49e2d8b93ae14f38dd5a7a1c9f3b9765 |
Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; SEAMEO Regional Center for Food and Nutrition, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia |
Sartika, A.N., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Khoirunnisa, M., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Meiyetriani, E., SEAMEO Regional Center for Food and Nutrition, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Ermayani, E., SEAMEO Regional Center for Food and Nutrition, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Pramesthi, I.L., SEAMEO Regional Center for Food and Nutrition, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Nur Ananda, A.J., SEAMEO Regional Center for Food and Nutrition, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia |
Background Childhood stunting remains the most challenging consequence of undernutrition because it is associated with suboptimal brain development and the subsequent increased risk of metabolic diseases and decreased earnings in adult life. The Sambas District in Indonesia has a high prevalence of stunting (28.4%), followed by underweight (25.5.%) and wasting (14.4%) among children, as well chronic energy deficiency (27%) and anemia (62%) among pregnant women. The present study sought to determine significant factors in childhood stunting with a focus on maternal and child nutrition and prenatal and postnatal determinants. Methods This prospective, repeat, cross-sectional study investigated factors associated with stunting among 559 infants age 0–11 months in Sambas District, Indonesia. Anthropometric measurements were performed by trained enumerators. Data from a 2016 survey of pregnant women and a 2017 survey on mothers and their children were used for postnatal data collection to quantify the prevalence of stunting at age 0–11 months. Using 20 potential predictors of stunting categorized by household characteristics, maternal characteristics, antenatal care services, and child characteristics, logistic regression analysis was conducted to assess the adjusted association between stunting and these factors. Results Of 559 children analyzed, 20.8% were stunted. In the model with low birth weight (LBW) as predictor for stunting, the odds of stunting increased significantly among children who weighed <2.500 g at birth; children who had diarrhea in the past 2 weeks and children who had incomplete basic immunization coverage as infants age 9–11 months. In model without LBW, the odds of stunting increased significantly among children who had preterm at birth, short maternal stature and children who had incomplete basic immunization coverage for 9–11 months infants. Conclusions Postnatal factors—preterm birth, low birth weight, diarrhea and complete basic immunization coverage—were associated with infant stunting in Sambas District, Indonesia. The prenatal factors such as short maternal stature were significant in the multivariate model. Policy makers, especially in the government, should recommend measures focused on those prenatal and postnatal factors to prevent stunting in children and to avoid the sequelae of childhood stunting in adult life. Copyright: © 2021 Sartika et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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anthropometry; Article; child nutrition; cross-sectional study; data collection method; diarrhea; female; government; health care policy; household; human; Indonesia; infant; low birth weight; major clinical study; male; maternal nutrition; newborn; perinatal period; predictor variable; premature labor; prenatal care; prenatal period; prevalence; prospective study; stunting; vaccination coverage; growth disorder; multivariate analysis; Anthropometry; Cross-Sectional Studies; Female; Growth Disorders; Humans; Indonesia; Infant; Infant, Newborn; Male; Multivariate Analysis; Prospective Studies |
Public Library of Science |
19326203 |
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34260622 |
Article |
Q1 |
990 |
4434 |
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309 |
Putri N.M., Kreshanti P., Aulia I., Syarif A.N., Tunjung N., Sukasah C.L. |
57192904294;36192866200;57204495153;57247430600;57208446370;57218391534; |
Use of local perforator flaps for closure of a thoraco-omphalopagus conjoined twin defect after separation during the COVID-19 pandemic |
2021 |
Heliyon |
7 |
7 |
e07443 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109574685&doi=10.1016%2fj.heliyon.2021.e07443&partnerID=40&md5=8fe6d81617877cb017dabe11c561c536 |
Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Putri, N.M., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kreshanti, P., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Aulia, I., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Syarif, A.N., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Tunjung, N., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sukasah, C.L., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: Conjoined twins are a rare medical phenomenon that poses unique challenges for surgeons. Separation of conjoined twins involves multidisciplinary teamwork, complex medical management and surgical planning, and multi-stage operations and often still has a high mortality and morbidity rate. In the times of the COVID-19 pandemic, separation of conjoined twins pose even greater challenges. Aiming for the best outcome possible, while minimizing the risk of COVID transmission and ensuring the safety of the personnel, is paramount. This case report presents thoraco-omphalopagus twins who were successfully separated at 4 months of age. The preoperative planning, operative details, postoperative follow-ups, and outcomes are discussed. Methods: The absence of a tissue expander and the inability to acquire it due to travel restrictions from COVID-19 further complicated the management on this patient. A Routine Polymerase Chain Reaction (PCR) swab test was performed on the patients and personnel. Standardized personnel protective equipment (PPE) was worn during ward and surgical care. After separation of the twins by cardiothoracic and pediatric surgeons, one twin underwent immediate skin closure using a double keystone perforator island flap and a lower abdominal perforator flap. Due to extensive defects, closure was delayed for the second twin. After a series of dressing changes, eventually local perforator flaps could be raised to close the defect using staged tension sutures and skin grafts for secondary defects. Results: Both twins were discharged with no significant morbidity, and no personnel were exposed to COVID-19 infection during the management. Conclusion: Preoperative coordination and planning, multidisciplinary effort, adherence to screening protocols for COVID, and strict use of standardized PPE all contributed to the successful separation of thoraco-omphalopagus conjoined twins during the COVID-19 pandemic. © 2021 The Author(s) |
Case report; COVID-19; Negative pressure wound therapy; Perforator flaps; Thoraco-omphalopagus conjoined twins |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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310 |
Situmorang H., Hestiantoro A., Purbadi S., Flamandita D., Sahlan M. |
57195939562;8743255100;6505677307;57216766308;57189182661; |
IN-SILICO dynamic analysis of Sulawesi propolis as anti-endometriosis drug: Interaction study with TNF alpha receptor, NF-kB, estrogen receptor, progesterone receptor and prostaglandin receptor |
2021 |
Annals of Medicine and Surgery |
67 |
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102459 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109547312&doi=10.1016%2fj.amsu.2021.102459&partnerID=40&md5=0f7d6fdeda084de97c22a80f60f7b2a7 |
Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Fuad Hasan, Pancoran MAS, Kukusan, Beji, Depok City, West Java 16424, Indonesia |
Situmorang, H., Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Hestiantoro, A., Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Purbadi, S., Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Flamandita, D., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Fuad Hasan, Pancoran MAS, Kukusan, Beji, Depok City, West Java 16424, Indonesia; Sahlan, M., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Fuad Hasan, Pancoran MAS, Kukusan, Beji, Depok City, West Java 16424, Indonesia |
Introduction: Endometriosis is a disease that impacts around 10% of all women in reproductive age, with pelvic pain and infertility as its main clinical features. Current medical treatment targeting lowering estrogen activity has not shown sufficient result due its side effects and reproductive function suppression. Propolis has been widely studied, showing anti inflammation and pro-apoptosis property, that could potentially be used in the treatment of endometriosis. This study investigates the interaction between Sulawesi Propolis’ active components and receptors and protein related to endometriosis pathogenesis. Methods: Active components of Sulawesi Propolis were initially identified with their targeted protein receptors. Lipinski rules were used to screen potential components. The ligands and proteins were tested using Autodock program to predict the most active compound and possible binding sites between propolis and some target proteins associated with inflammatory and apoptotic activity in endometriosis models. Receptor modelling is then performed using Swiss-Model. Results: These active components of Sulawesi Propolis showed a strong binding potential towards TNF- α, NF-kb, Estrogen-α, Estrogen-β, progesterone B, PGE2 EP2 and EP3 subtype respectively: Sanggenon C, Sanggenon H, Epicryptoacetalide, Chrysin-7-O-β-D-glucopyranodside, Irilone, Polydatin and Epicryptoacetalide. Compared to its negative ligand, Sulawesi Propolis displayed a stronger binding capacity to TNF-α, Estrogen-α, and Progesterone B receptors. Conclusion: Sulawesi Propolis has the ability to interact with receptors related to reproductive function, apoptotic reactions and inflammatory processes, a significant factor associated with the pathogenesis of endometriosis. © 2021 |
Docking; Endometriosis; Estrogen receptor; In silico; NF-kB; Progesterone receptor; Propolis; Prostaglandin receptor; TNF alpha Receptor |
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Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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311 |
Sunardi D., Bardosono S., Basrowi R.W., Wasito E., Vandenplas Y. |
57192075078;21933841000;57024210400;6506940239;57223670656; |
Dietary determinants of anemia in children aged 6–36 months: A cross-sectional study in Indonesia |
2021 |
Nutrients |
13 |
7 |
2397 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109524537&doi=10.3390%2fnu13072397&partnerID=40&md5=2e8ac565ce8b6f3dd3f70a2de509a9ad |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Vrije Universiteit Brussel (VUB), UZ Brussels, KidZ Health Castle, Brussels, 1090, Belgium |
Sunardi, D., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Basrowi, R.W., Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Wasito, E., Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Vandenplas, Y., Vrije Universiteit Brussel (VUB), UZ Brussels, KidZ Health Castle, Brussels, 1090, Belgium |
Anemia has been acknowledged as worldwide problem, including in Indonesia. This cross-sectional study aims to explore dietary determinants as risk factors for anemia in children aged 6–36 months living in a poor urban area of Jakarta. The study was done in Kampung Melayu sub-district in Jakarta, Indonesia. Data was collected within two weeks in September–October 2020. A structured questionnaire for a 24-h recall and a semi-quantitative Food Frequency Questionnaire (FFQ) were used to collect the dietary intake data, and venous blood was withdrawn to determine the hemoglobin levels. Bivariate chi-square and multiple logistic regression tests were executed to explore the dietary determinant factors for anemia. We recruited 180 subjects. The average hemoglobin concentration was 11.4 ± 1.7 mg/dL; the anemia prevalence was 29.4%. The following variables were significantly associated with higher risk of anemia: no cow’s milk formula consumption, inadequate intake of fats, protein, calcium, vitamin D, iron, zinc, vitamin A, vitamin C, vitamin B6, and vitamin B12. Only cow’s milk formula consumption and zinc intake were revealed as the determinant factors of anemia. In conclusion, the prevalence of anemia was 29.4% among children aged 6–36 months old. Anemia was significantly associated with two dietary determinants as risk factors that are cow’s milk formula consumption and zinc intake. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Anemia; Cow’s milk; Cow’s milk formula; Indonesia; Toddler; Zinc |
biological marker; hemoglobin; zinc; adverse event; age; anemia; artificial milk; blood; bottle feeding; cross-sectional study; diet; female; human; Indonesia; infant; infant nutrition; male; metabolism; nutritional status; pathophysiology; preschool child; prevalence; risk assessment; risk factor; urban health; Age Factors; Anemia; Biomarkers; Bottle Feeding; Child, Preschool; Cross-Sectional Studies; Diet; Diet Surveys; Female; Hemoglobins; Humans; Indonesia; Infant; Infant Formula; Infant Nutritional Physiological Phenomena; Male; Nutritional Status; Prevalence; Risk Assessment; Risk Factors; Urban Health; Zinc |
MDPI AG |
20726643 |
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34371908 |
Article |
Q1 |
1418 |
2497 |
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312 |
Mantiri B.J., Sigumonrong Y. |
57211646737;57209291346; |
Bilateral adrenal tumor: A case report and current challenges |
2021 |
International Journal of Surgery Case Reports |
84 |
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106134 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109442036&doi=10.1016%2fj.ijscr.2021.106134&partnerID=40&md5=6e73ca95877115564bd2d8829933ec42 |
Urology Resident of Urology Department, Faculty of Medicine, Universitas Indonesia - H. Adam Malik Hospital, Medan, Indonesia; Urology Consultant of Urology Department, Faculty of Medicine, Universitas Indonesia - H. Adam Malik Hospital, Medan, Indonesia |
Mantiri, B.J., Urology Resident of Urology Department, Faculty of Medicine, Universitas Indonesia - H. Adam Malik Hospital, Medan, Indonesia; Sigumonrong, Y., Urology Consultant of Urology Department, Faculty of Medicine, Universitas Indonesia - H. Adam Malik Hospital, Medan, Indonesia |
Introduction: A bilateral adrenal tumor is a rare case. It differs significantly from unilateral adrenal mass since it is related strongly to genetic and family history. Adrenocortical Carcinoma might cause related hormonal syndromes such as Cushing syndrome, Conn syndrome, and virilization. Aim: This study aims to report an uncommon presentation of a 15-year-old female with bilateral Adrenal Tumor since an early age with virilization as the main symptoms. Case presentation: The patient is a 15-year-old girl with female genitalia presentation. She complained of a bulging mass on her right flank with pain four years ago. The mass size grew progressively and initially painless. However, the patient started to feel pain a year ago. Since she was six years old, the mass started to appear on the left flank, and then it also started to appear on the right side. The mass appearance is simultaneous with virilization symptom development, such as the emergence of facial hair, mustache, and sideburns. In 2020, MRI showed a lesion on the right suprarenal with contrast enhancement with 14.5 × 11.5 cm in size, and a 5.6 × 4 cm recurrent left suprarenal lesion. The patient underwent right adrenalectomy resection surgery on January 21st, 2021. The immunohistochemistry examination suggested Adrenocortical Carcinoma. Conclusion: Adrenocortical Carcinoma is a hormone-secreting tumor that might affect the patient's condition systematically. Neglected cases of adrenal cortical carcinoma might affect secondary sexual organ development in the long term. Thus, an early diagnosis and treatment are paramount for this case. © 2021 |
Adrenalectomy; Bilateral adrenocortical carcinoma; Virilization |
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Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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313 |
Rahayatri T.H., Amaliah R., Putri N.M., Puspaningtyas N.W., Karyanti M.R., Hendarto A. |
57188549965;57224001785;57192904294;57223288515;56290680800;57204142249; |
Omphalopagus conjoined twins separation during coronavirus disease-19 pandemic era: A case report |
2021 |
International Journal of Surgery Case Reports |
84 |
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106150 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109424878&doi=10.1016%2fj.ijscr.2021.106150&partnerID=40&md5=a376a2af0ee2eeb9a9da557e67166686 |
Faculty of Medicine, Universitas Indonesia, Pediatric Surgery Division, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Plastic Surgery Division, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Pediatric Intensive Care Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Pediatric Infectious and Tropical Disease Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Pediatric Nutrition and Metabolic Disease Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Rahayatri, T.H., Faculty of Medicine, Universitas Indonesia, Pediatric Surgery Division, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Amaliah, R., Faculty of Medicine, Universitas Indonesia, Pediatric Surgery Division, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Putri, N.M., Faculty of Medicine, Universitas Indonesia, Plastic Surgery Division, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Puspaningtyas, N.W., Faculty of Medicine, Universitas Indonesia, Pediatric Intensive Care Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Karyanti, M.R., Faculty of Medicine, Universitas Indonesia, Pediatric Infectious and Tropical Disease Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hendarto, A., Faculty of Medicine, Universitas Indonesia, Pediatric Nutrition and Metabolic Disease Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction and importance: Conjoined twin is a rare congenital anomaly characterized by a fusion of certain anatomical structures. Coronavirus-19 (COVID-19) is a new emerging infectious respiratory disease affecting worldwide and potentially leads to acute respiratory distress (ARDS) in children. COVID-19 has reconstructed the healthcare system, including surgical care and decision-making. Case presentation: Herein we describe a surgical separation of 2.5 months old omphalopagus conjoined twins, with one of them (Baby A) presenting COVID-19-associated respiratory distress, as well as the challenges faced during the preparation and the execution of the complex surgical procedure. Clinical discussion: Baby A underwent antiviral therapy, oxygen supplementation, and ventilation in the ICU, while baby B remained stable and confirmed negative for SARS-CoV-2. The separation surgery was conducted after baby A had become clinically stable. Defect closure and reconstruction were accomplished. At one week follow-up, Baby A died of lung infection, while baby B remained well after one year. Conclusion: The complexity of surgical separation requires careful planning by a multidisciplinary team. Surgical separation of conjoined twins during the pandemic era has not been reported much in the literature, more reports are required to provide further insight. © 2021 The Authors |
Case report; Children; Conjoined twins separation; COVID-19; Omphalopagus conjoined twins |
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Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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314 |
Kreshanti P., Putri N.T., Martin V.J., Sukasah C.L. |
36192866200;57192904294;57221635093;57218391534; |
The effectiveness of oral propranolol for infantile hemangioma on the head and neck region: A case series |
2021 |
International Journal of Surgery Case Reports |
84 |
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106120 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109354279&doi=10.1016%2fj.ijscr.2021.106120&partnerID=40&md5=d7e0ac8c9d5ad4046f2b8c78dc622412 |
Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kreshanti, P., Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Putri, N.T., Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Martin, V.J., Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sukasah, C.L., Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Infantile hemangioma is the most common tumor in infancy, with 60% occurring on the face and neck. A large tumor involving the facial region will cause significant aesthetic and functional impairment and isn't always easy to treat surgically. A non-invasive treatment is needed for this condition. Propranolol has recently been used as a choice of treatment in infantile hemangioma. Presentation of case: We presented two cases of large problematic infantile hemangioma that were successfully managed with oral propranolol. Discussion: Large problematic lesions that ulcerate and bleed often need surgery; however, a substantial defect resulting from surgery is tricky to reconstruct and can cause significant scar. Propranolol is used because of its efficacy and low risk characteristics. Conclusion: Propranolol is an effective treatment to reduce the need of surgical intervention in problematic hemangioma. © 2021 The Authors |
Case report; Infantile hemangioma; Propranolol; Surgery |
eye ointment; gentamicin; propranolol; blood pressure monitoring; capillary hemangioma; case report; cheek; child; clinical article; clinical effectiveness; clinical feature; dermatologist; drug dose increase; drug efficacy; ecchymosis; eye protection; eyelid; female; head and neck disease; heart rate measurement; human; lung function test; male; neoplasm; ophthalmologist; palpation; patient referral; preschool child; risk; Short Survey; skin color; skin ulcer; tumor volume |
Elsevier Ltd |
22102612 |
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Short Survey |
Q3 |
232 |
17549 |
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315 |
Purnomo G.A., Mitchell K.J., O’connor S., Kealy S., Taufik L., Schiller S., Rohrlach A., Cooper A., Llamas B., Sudoyo H., Teixeira J.C., Tobler R. |
56262110300;55937278100;57192065848;57016654100;57225108034;57225091129;56674549200;57225849511;8695218700;6603548824;56290678400;55780763900; |
Mitogenomes reveal two major influxes of papuan ancestry across wallacea following the last glacial maximum and austronesian contact |
2021 |
Genes |
12 |
7 |
965 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109185551&doi=10.3390%2fgenes12070965&partnerID=40&md5=046fa96fdfa7683fb4a23714ea942197 |
Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia; Genome Diversity and Diseases Laboratory, Eijkman Institute of Molecular Biology, Jakarta, 10430, Indonesia; ARC Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, 5005, Australia; Archaeology and Natural History, School of Culture, History and Language, College of Asia and the Pacific, Australian National University, Canberra, 2601, Australia; ARC Centre of Excellence for Australian Biodiversity and Heritage, Australian National University, Canberra, 2601, Australia; Evolution of Cultural Diversity Initiative, Australian National University, Canberra, 2601, Australia; ARC Centre of Excellence for Mathematical and Statistical Frontiers, School of Mathematical Sciences, The University of Adelaide, Adelaide, 5005, Australia; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, 07745, Germany; Blue Sky Genetics, P.O. Box 287, Adelaide, 5137, Australia; South Australian Museum, Adelaide, 5000, Australia; Environment Institute, University of Adelaide, Adelaide, 5005, Australia; National Centre for Indigenous Genomics, Australian National University, Canberra, 2601, Australia; Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Sydney Medical School, University of Sydney, Sydney, 2050, Australia |
Purnomo, G.A., Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia, Genome Diversity and Diseases Laboratory, Eijkman Institute of Molecular Biology, Jakarta, 10430, Indonesia; Mitchell, K.J., Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, 5005, Australia; O’connor, S., Archaeology and Natural History, School of Culture, History and Language, College of Asia and the Pacific, Australian National University, Canberra, 2601, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, Australian National University, Canberra, 2601, Australia; Kealy, S., Archaeology and Natural History, School of Culture, History and Language, College of Asia and the Pacific, Australian National University, Canberra, 2601, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, Australian National University, Canberra, 2601, Australia, Evolution of Cultural Diversity Initiative, Australian National University, Canberra, 2601, Australia; Taufik, L., Genome Diversity and Diseases Laboratory, Eijkman Institute of Molecular Biology, Jakarta, 10430, Indonesia; Schiller, S., ARC Centre of Excellence for Mathematical and Statistical Frontiers, School of Mathematical Sciences, The University of Adelaide, Adelaide, 5005, Australia; Rohrlach, A., ARC Centre of Excellence for Mathematical and Statistical Frontiers, School of Mathematical Sciences, The University of Adelaide, Adelaide, 5005, Australia, Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, 07745, Germany; Cooper, A., Blue Sky Genetics, P.O. Box 287, Adelaide, 5137, Australia, South Australian Museum, Adelaide, 5000, Australia; Llamas, B., Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, 5005, Australia, Environment Institute, University of Adelaide, Adelaide, 5005, Australia, National Centre for Indigenous Genomics, Australian National University, Canberra, 2601, Australia; Sudoyo, H., Genome Diversity and Diseases Laboratory, Eijkman Institute of Molecular Biology, Jakarta, 10430, Indonesia, Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia, Sydney Medical School, University of Sydney, Sydney, 2050, Australia; Teixeira, J.C., Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, 5005, Australia, Evolution of Cultural Diversity Initiative, Australian National University, Canberra, 2601, Australia; Tobler, R., Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, 5005, Australia, Evolution of Cultural Diversity Initiative, Australian National University, Canberra, 2601, Australia |
The tropical archipelago of Wallacea contains thousands of individual islands interspersed between mainland Asia and Near Oceania, and marks the location of a series of ancient oceanic voyages leading to the peopling of Sahul—i.e., the former continent that joined Australia and New Guinea at a time of lowered sea level—by 50,000 years ago. Despite the apparent deep antiquity of human presence in Wallacea, prior population history research in this region has been hampered by patchy archaeological and genetic records and is largely concentrated upon more recent history that follows the arrival of Austronesian seafarers ~3000–4000 years ago (3–4 ka). To shed light on the deeper history of Wallacea and its connections with New Guinea and Australia, we performed phylogeographic analyses on 656 whole mitogenomes from these three regions, including 186 new samples from eight Wallacean islands and three West Papuan populations. Our results point to a surprisingly dynamic population history in Wallacea, marked by two periods of extensive demographic change concentrated around the Last Glacial Maximum ~15 ka and post-Austronesian contact ~3 ka. These changes appear to have greatly diminished genetic signals informative about the original peopling of Sahul, and have important implications for our current understanding of the population history of the region. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Human migrations; Mitochondria; MtDNA; Phylogeography; Sahul |
mitochondrial DNA; ancestry group; Article; Asia; Australia; Austronesian people; biogeographic region; gene sequence; haplotype; human; last glacial maximum; migration; mitochondrial genome; Papua New Guinea; Philippines; phylogeny; phylogeography; polymerase chain reaction; population size; population structure; sailor; sequence alignment; simulation; Wallacea; animal; archeology; beetle; female; genetics; history; male; mitochondrial genome; Pacific islands; phylogeny; phylogeography; population genetics; Animals; Archaeology; Asia; Australia; Coleoptera; Female; Genetics, Population; Genome, Mitochondrial; Haplotypes; History, Ancient; Humans; Male; New Guinea; Oceania; Phylogeny; Phylogeography |
MDPI |
20734425 |
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34202821 |
Article |
Q2 |
1337 |
2737 |
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