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Nakhaei P., Margiana R., Bokov D.O., Abdelbasset W.K., Jadidi Kouhbanani M.A., Varma R.S., Marofi F., Jarahian M., Beheshtkhoo N. |
57226413840;56685900600;56845561300;57208873763;57219274421;7201793587;57199650994;16241593900;57201547070; |
Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol |
2021 |
Frontiers in Bioengineering and Biotechnology |
9 |
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705886 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115653337&doi=10.3389%2ffbioe.2021.705886&partnerID=40&md5=0d6cee3ed2be3a97e6c2beb3d6c668b5 |
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia; Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation; Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology, and Food Safety, Moscow, Russian Federation; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Czech Republic; Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacký University in Olomouc, Olomouc, Czech Republic; Department of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany |
Nakhaei, P., School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia, Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia, Master’s Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Bokov, D.O., Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation, Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology, and Food Safety, Moscow, Russian Federation; Abdelbasset, W.K., Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Jadidi Kouhbanani, M.A., Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Czech Republic; Varma, R.S., Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacký University in Olomouc, Olomouc, Czech Republic; Marofi, F., Department of Hematology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Jarahian, M., Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany; Beheshtkhoo, N., Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Czech Republic |
Liposomes are essentially a subtype of nanoparticles comprising a hydrophobic tail and a hydrophilic head constituting a phospholipid membrane. The spherical or multilayered spherical structures of liposomes are highly rich in lipid contents with numerous criteria for their classification, including structural features, structural parameters, and size, synthesis methods, preparation, and drug loading. Despite various liposomal applications, such as drug, vaccine/gene delivery, biosensors fabrication, diagnosis, and food products applications, their use encounters many limitations due to physico-chemical instability as their stability is vigorously affected by the constituting ingredients wherein cholesterol performs a vital role in the stability of the liposomal membrane. It has well established that cholesterol exerts its impact by controlling fluidity, permeability, membrane strength, elasticity and stiffness, transition temperature (Tm), drug retention, phospholipid packing, and plasma stability. Although the undetermined optimum amount of cholesterol for preparing a stable and controlled release vehicle has been the downside, but researchers are still focused on cholesterol as a promising material for the stability of liposomes necessitating explanation for the stability promotion of liposomes. Herein, the prior art pertaining to the liposomal appliances, especially for drug delivery in cancer therapy, and their stability emphasizing the roles of cholesterol. © Copyright © 2021 Nakhaei, Margiana, Bokov, Abdelbasset, Jadidi Kouhbanani, Varma, Marofi, Jarahian and Beheshtkhoo. |
cholesterol; compounds; lipids; liposome; stability |
Automobile manufacture; Chemical stability; Controlled drug delivery; Food products; Liposomes; Medical applications; Phospholipids; Plasma stability; Targeted drug delivery; Application parameters; Biomedical applications; Compound; Hydrophilic heads; Hydrophobic tails; Liposome structures; Multi-layered; Phospholipid membrane; Spherical structures; Stability parameters; Cholesterol |
Frontiers Media S.A. |
22964185 |
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1081 |
3891 |
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178 |
Yamada C., Siste K., Hanafi E., Ophinni Y., Beatrice E., Rafelia V., Alison P., Limawan A., Shinozaki T., Matsumoto T., Sakamoto R. |
57222342981;55644113100;56737010600;57198779809;57215769595;57253865100;57254672000;57202712511;55129157400;55624483618;23992806400; |
Relapse prevention group therapy via video-conferencing for substance use disorder: Protocol for a multicentre randomised controlled trial in Indonesia |
2021 |
BMJ Open |
11 |
9 |
e050259 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114681155&doi=10.1136%2fbmjopen-2021-050259&partnerID=40&md5=f40f8485b5314829dcd4365ab57bf817 |
Department of Environmental Coexistence, Center for Southeast Asian Studies, Kyoto University, Kyoto, Japan; Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ragon Institute of Mgh, Mit and Harvard, Cambridge, MA, United States; Department of Information and Computer Technology, Faculty of Engineering, Tokyo University of Science, Tokyo, Japan; Department of Drug Dependence Research, National Center of Neurology and Psychiatry, Tokyo, Japan |
Yamada, C., Department of Environmental Coexistence, Center for Southeast Asian Studies, Kyoto University, Kyoto, Japan; Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hanafi, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ophinni, Y., Ragon Institute of Mgh, Mit and Harvard, Cambridge, MA, United States; Beatrice, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rafelia, V., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Alison, P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Limawan, A., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Shinozaki, T., Department of Information and Computer Technology, Faculty of Engineering, Tokyo University of Science, Tokyo, Japan; Matsumoto, T., Department of Drug Dependence Research, National Center of Neurology and Psychiatry, Tokyo, Japan; Sakamoto, R., Department of Environmental Coexistence, Center for Southeast Asian Studies, Kyoto University, Kyoto, Japan |
Background Substance use disorder (SUD) is a leading contributor to the global burden of disease. In Indonesia, the availability of formal treatment for SUD falls short of the targeted coverage. A standardised therapeutic option for SUD with potential for widespread implementation is required, yet evidence-based data in the country are scarce. In this study, we developed a cognitive behavioural therapy (CBT)-based group telemedicine model and will investigate effectiveness and implementability in a multicentre randomised controlled trial. Methods A total of 220 participants will be recruited from the social networks of eight sites in Indonesia: three hospitals, two primary healthcare centres and three rehabilitation centres. The intervention arm will participate in a relapse prevention programme called the Indonesia Drug Addiction Relapse Prevention Programme (Indo-DARPP), a newly developed 12-week module based on CBT and motivational interviewing constructed in the Indonesian context. The programme will be delivered by a healthcare provider and a peer counsellor in a group therapy setting via video-conferencing, as a supplement to participants' usual treatments. The control arm will continue treatment as usual. The primary outcome will be the percentage increase in days of abstinence from the primarily used substance in the past 28 days. Secondary outcomes will include addiction severity, quality of life, motivation to change, psychiatric symptoms, cognitive function, coping, and internalised stigma. Assessments will be performed at baseline (week 0), post-treatment (week 13), and 3 and 12 months post-treatment completion (weeks 24 and 60). Retention, participant satisfaction, and cost-effectiveness will be assessed as the implementation outcomes. Ethics and dissemination The study protocol was reviewed and approved by the Ethics Committees of Universitas Indonesia and Kyoto University. The results will be disseminated via academic journals and international conferences. Depending on trial outcomes, the treatment programme will be advocated for adoption as a formal healthcare-based approach for SUD. Trial registration number UMIN000042186. © 2021 BMJ Publishing Group. All rights reserved. |
clinical trials; psychiatry; substance misuse; telemedicine |
Article; benzodiazepine dependence; cannabis addiction; cognition; cognitive behavioral therapy; controlled study; coping behavior; cost effectiveness analysis; counselor; disease severity; drug dependence; drug withdrawal; group therapy; health care personnel; heroin dependence; human; Indonesia; major clinical study; mental disease; methamphetamine dependence; motivational interviewing; multicenter study; opiate addiction; outcome assessment; patient satisfaction; preventive health service; program effectiveness; quality of life; randomized controlled trial; relapse; stigma; teleconference; videoconferencing; cost benefit analysis; multicenter study (topic); randomized controlled trial (topic); secondary prevention; Cost-Benefit Analysis; Humans; Indonesia; Multicenter Studies as Topic; |
BMJ Publishing Group |
20446055 |
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34489288 |
Article |
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3624 |
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183 |
Raharjanti N.W., Purwadianto A., Soemantri D., Bardosono S., Mahajudin M.S., Poerwandari E.K., Levania M.K., Silalahi H.M.T.S., Rumthi P.T.S., Manulang T.K.P., Ramadianto A.S., Wiguna T. |
57226872499;18635479200;36640659100;21933841000;57218600581;25628305200;57226868672;57368578800;57368162800;57367333500;57226862690;24367785700; |
Self-confidence in conducting forensic psychiatric evaluations among general psychiatrists in Indonesia |
2021 |
Heliyon |
7 |
9 |
e08045 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120891523&doi=10.1016%2fj.heliyon.2021.e08045&partnerID=40&md5=2915417d45113bc152dbacad697562ef |
Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Forensic Department, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Nutrition Department, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Psychiatry, Airlangga University, Surabaya, East Java, Indonesia; Faculty of Psychology, Universitas Indonesia, Jakarta, Indonesia |
Raharjanti, N.W., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Purwadianto, A., Forensic Department, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soemantri, D., Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Bardosono, S., Nutrition Department, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Mahajudin, M.S., Department of Psychiatry, Airlangga University, Surabaya, East Java, Indonesia; Poerwandari, E.K., Faculty of Psychology, Universitas Indonesia, Jakarta, Indonesia; Levania, M.K., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Silalahi, H.M.T.S., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rumthi, P.T.S., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Manulang, T.K.P., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ramadianto, A.S., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wiguna, T., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Objective: Several general psychiatrists experience lack of confidence when they perform forensic psychiatric evaluations that may be due to limited or insufficient training. This study aimed to determine whether structured forensic psychiatry educational modules are associated with general psychiatrists’ self-confidence in conducting forensic psychiatric evaluations in Indonesia. Method: A cross-sectional study was conducted with 246 general psychiatrists. A questionnaire was developed exclusively for this study by a group of experts based on relevant references and it was distributed online. Sample questions included: “How often do you perform forensic psychiatric evaluations?”, “As a general psychiatrist, are you confident in conducting forensic psychiatric evaluations?”, and “Do you experience any difficulties when conducting forensic psychiatric evaluations?” Data were analyzed through SPSS 20 for Windows; a p-value <0.05 indicated statistical significance. Results: Compared to general psychiatrists who did not study structured forensic psychiatry educational modules during their residency training, those exposed to such modules reported confidence in conducting forensic psychiatric evaluations in the following cases: insanity defense in cases of violence, insanity defense, fitness to stand trial, malingering, capacity to consent to treatment, risk of recidivism, guardianship, and parenting capacity. Furthermore, those with higher self-confidence were less likely to experience difficulties in conducting forensic psychiatric evaluations. Conclusion: Structured forensic psychiatry educational modules during general psychiatry residency training played an important role in the development of psychiatrists’ self-confidence. © 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license |
Forensic psychiatry module; Indonesia; Psychiatric evaluation; Self-confidence |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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184 |
Octaviana F., Harisman J., Wiratman W., Budikayanti A. |
26029958700;57368215900;57191920526;57194713932; |
Altered mental status in moderate-severe traumatic brain injury in Indonesia: the clinical manifestation and EEG features of non-convulsive status epilepticus |
2021 |
Heliyon |
7 |
9 |
e08067 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120866388&doi=10.1016%2fj.heliyon.2021.e08067&partnerID=40&md5=87d284823bcddaa9acf0b35b27598f23 |
Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia; Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Octaviana, F., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Harisman, J., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia; Wiratman, W., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Budikayanti, A., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Introduction: Moderate-to-severe traumatic brain injury (msTBI) can cause non-convulsive status epilepticus (NCSE). Electroencephalography (EEG) is employed as a diagnostic tool due to the non-specificity of clinical symptoms. This study aimed to identify clinical and EEG features related to NCSE in patients with msTBI. Methods: This was a cross-sectional study. Suspected NCSE in msTBI was examined using EEG data collected in consecutive patients from January 2017 to December 2019 at Dr. Cipto Mangunkusumo Hospital, Jakarta. Diagnoses of NCSE were made based on clinical manifestations and EEG features using the modified Salzburg Consensus Criteria for NCSE (mSCNC). Results: Of the 39 msTBI patients, 19 were diagnosed with NCSE; only two fulfilled the definitive criteria, and the remaining were possible NCSE. Delirium and perceptual impairment were only found in NCSE, while psychomotor agitation was higher (12.8% vs. 5.1% in NCSE vs. non-NCSE). The most common EEG feature was rhythmic activity (>0.5 Hz) without fluctuation, which improved with anti-epileptic drug administration. The Glasgow Coma Scale (GCS) score at onset and at hospitalisation discharge was significantly lower in patients with NCSE. The lesions in NCSE mostly originated from the temporal lobe. Injury to the temporal lobe had a significant relationship with NCSE occurrence (p ¼ 0.036, odds ratio 11.45 [95% confidence interval 1.17–111.6]). In this study, delirium, perceptual impairment, and psychomotor agitation were confirmed as NCSE using The most common discharge originated from the injured temporal lobe, and this site was a significant factor NCSE in patients with msTBI. in msTBI cases with clinical manifestations of altered mental status, psychomotor An injured temporal lobe was a susceptible site for the development of NCSE © 2021,Heliyon.All Rights Reserved. |
Altered mental status; Moderate-severe TBI; mSCNC; Non-convulsive status epilepticus |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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185 |
Kartika R.W., Alwi I., Suyatna F.D., Yunir E., Waspadji S., Immanuel S., Silalahi T., Sungkar S., Rachmat J., Reksodiputro M.H., Bardosono S. |
57223447932;15055173800;56039633100;36520254800;8678136400;57272979000;56275255400;57016857300;6507225348;35090488800;21933841000; |
The Role Of Vegf, Pdgf And Il-6 On Diabetic Foot Ulcer After Platelet Rich Fibrin Þ Hyaluronic Therapy |
2021 |
Heliyon |
7 |
9 |
e07934 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120851420&doi=10.1016%2fj.heliyon.2021.e07934&partnerID=40&md5=0080e19d2c656e3452c7827d2fab24ba |
Doctoral Program in Medical Science, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Department of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Thorcic Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kartika, R.W., Doctoral Program in Medical Science, Faculty of Medicine, Universitas Indonesia, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Sungkar, S., Department of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rachmat, J., Department of Thorcic Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Reksodiputro, M.H., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Current standard management of diabetic foot ulcers (DFUs) consists of surgical debridement followed by soak NaCl 0.9% gauzes tight infection and glycaemic control. Nowadays the use of advanced plateletrich fibrin (A-PRF) has emerged as an adjunctive method for treating DFUs. This study was conducted to demonstrate the ability of combine A-PRF þ HA as a complementary therapy in DFUs healing related with angiogenesis,inflammation and granulation index process. Methods: This open label randomized controlled trial was conducted in Koja District Hospital and Gatot Soebroto Hospital Jakarta, Indonesia on July 2019–April 2020. DFUs patients with wound duration of three months, Wagner-2, with size of ulcer less than 40 cm2 were included in the study. The number of subjects was calculated based on the rule of thumb and allocated randomly into three groups, namely topical A-PRF þ HA, A-PRF an Sodium Chloride 0.9% as a control, for each of 10 subjects. A-PRF made by 10 mL venous blood, centrifuge 200 G in 10 min, meanwhile A-PRF þ HA though mix both them with vertex machine around 5 min. Biomarker such as VEGF, PDGF and IL-6 examined from DFU taken by cotton swab and analysis using ELISA. Granulation Index was measured using ImageJ. Biomarkers and granulation index were evaluated on day 0, 3, 7 and 14. Data were analysed using SPSS version 20 with Anova and Kruskal Wallis test to compare the angiogenesis and inflammation effect between the three groups. Result: In topical dressing A-PRF þ HA, there is an increase in delta VEGF on day-3 (43.1 pg/mg protein) and day-7 (275,8 pg/mg protein) compared to A-PRF on day-3 (1.8 pg/mg protein) and day-7 (104.7 pg/mg protein), also NaCl (control) on day-3 (-4.9 pg/mg protein) and day-7 (28.3 pg/mg protein). So that the delta VEGF of A-PRF þ HA group increase significantly compared with others on day-3 (p ¼ 0.003) and day-7 (p < 0.001). Meanwhile APRF þ AH group, there is also a decrease in delta IL-6 after therapy on day-3 (-10.9 pg/mg protein) and day-7 (-18.3 pg/mg protein) compared to A-PRF in delta IL-6 on day-3 (-3.7 pg/mg protein) and on day-7 (-7.8 pg/ mg protein). In NaCl (control) group there is a increase delta IL-6 on day-3 (4.3 pg/mg protein) and on day-7 (35.5 pg/mg protein). So that the delta IL-6 of A-PRF þ HA group decrease significantly compared with others only on day-7 (p ¼ 0.015). In PDGF le level analysis, A-PRF þ HA group increase significantly (p ¼ 0.012) only in day -7 compare with other group (5.5 pg/mg protein). Conclusion: The study shows the superior role of combined A-PRF þ HA in the treatment DFU though increase angiogenesis and decrease inflammation pathway. The advantage of using A-PRF þ HA is that it accelerates wound healing by increasing granulation tissue compared to A-PRF alone © 2021 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
Diabetic foot ulcer; Hyaluronic acid; Platelet-rich fibrin |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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186 |
Sauriasari R., Madani R.A., Rozaliyani A., Sudiana D. |
16246507200;57367966600;57203065912;21934788800; |
The effect of repeated education using live demonstrations and videos of how to use inhalation drugs on quality of life for COPD patients |
2021 |
Heliyon |
7 |
9 |
e07870 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120850425&doi=10.1016%2fj.heliyon.2021.e07870&partnerID=40&md5=9a57b37dd2d801600bfd6633e55ec700 |
Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia |
Sauriasari, R., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia; Madani, R.A., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia; Rozaliyani, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sudiana, D., Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia |
Repeated education regarding the proper use of inhalers can reduce the error rate in inhaler-using patients and improve COPD patients’ quality of life. This study investigates the effect of repeated education on the quality of life of COPD patients during the pandemic of COVID-19 from February to June 2020. Repeated education is provided using direct demonstrations to patients through educational media in the form of short videos made by the researchers for each inhaler type. This is a pre-experimental study design which was carried out prospectively at Grha Permata Ibu Hospital, Depok. The quality of life of 22 subjects was examined using the COPD assessmenttest (CAT) questionnaire. Each patient was given a direct verbal demonstration of the appropriate use of the inhaler. One month later, each patient was provided further education using less than 2 min of video sent to them online via the WhatsApp application. Final quality-of-life examination and assessment of inhaler technique were carried out three months after the initial examination. Assessment of proper inhaler technique was carried out using a specific checklist regarding the use of inhaler translated by the researcher. Before and after delivery of repeated education, the mean CAT score showed a decrease of two points, i.e., 12.8 ± 1.3 and 10.8 ± 2.0, respectively. This indicated that quality of life of the patients had significant improvement. However, as many as 63.6% of patients still made mistakes in using inhaler even though they had been educated. For DPI-type inhalers, mistake mostly happened at step “breath out gently, away from inhaler”. For pMDI-type inhalers, mistake mostly happened at step “while holding breath, remove inhaler from mouth”. It can be concluded that repeated education regarding proper inhaler technique with direct demonstrations and further maintained by videos can improve the quality of life in COPD patients. © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). |
CAT (COPD Assessment test); Demonstration video; Inhaler; Repeated education |
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Elsevier Ltd |
24058440 |
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455 |
10919 |
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199 |
Tunjungputri R.N., Tetrasiwi E.N., Veronica M., Pandelaki J., Ibrahim F., Nelwan E.J. |
56342194400;57267704700;57268337000;35759266900;57226400046;14527452900; |
Vaccine-associated disease enhancement: a case report of post-vaccination COVID-19 |
2021 |
International Journal of Antimicrobial Agents |
58 |
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21003575 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115401929&doi=10.1016%2fj.ijantimicag.2021.106421.86&partnerID=40&md5=46457ba71f5610aae7b204755fcef50d |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Microbiology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Infectious Disease and Immunology Research Center—IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tunjungputri, R.N., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Tetrasiwi, E.N., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Veronica, M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pandelaki, J., Department of Radiology, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Ibrahim, F., Microbiology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nelwan, E.J., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia and Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Infectious Disease and Immunology Research Center—IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
[No abstract available] |
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Elsevier B.V. |
09248579 |
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Article |
Q1 |
1454 |
2387 |
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200 |
Fadrian F., Nelwan E.J., Kurniawan J., Pohan H.T. |
57268114000;14527452900;57193251655;23474782900; |
Risk of infection with multiple pathogen in post liver transplantation patient in referral centre in Jakarta, Indonesia |
2021 |
International Journal of Antimicrobial Agents |
58 |
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21003320 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115366248&doi=10.1016%2fj.ijantimicag.2021.106421.61&partnerID=40&md5=e23afb1d78408e73580d689f6327bb02 |
Department of Internal Medicine;; Division of Tropical and Infectious Disease;; Division of Hepatology Faculty of Medicine Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta, Indonesia |
Fadrian, F., Department of Internal Medicine;; Nelwan, E.J., Department of Internal Medicine;, Division of Tropical and Infectious Disease;; Kurniawan, J., Department of Internal Medicine;, Division of Hepatology Faculty of Medicine Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Pohan, H.T., Department of Internal Medicine;, Division of Tropical and Infectious Disease; |
[No abstract available] |
aspergillosis.; biloma; CMV; post liver transplantation infection |
|
Elsevier B.V. |
09248579 |
|
|
Article |
Q1 |
1454 |
2387 |
|
|
201 |
Tunjungputri R.N., Tetrasiwi E.N., Rizqa T., Mulansari N.A., Harimurti K. |
56342194400;57267704700;57268337300;36519326000;23473513200; |
Parenteral and oral anticoagulant treatment for hospitalized and post-discharge patients with COVID-19: A systematic review |
2021 |
International Journal of Antimicrobial Agents |
58 |
|
21003587 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115349747&doi=10.1016%2fj.ijantimicag.2021.106421.87&partnerID=40&md5=c258c13fa4bd248528cd36e04d4d4fd4 |
Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital;; Division of Hematology and Medical Oncology, Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital |
Tunjungputri, R.N., Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital;; Tetrasiwi, E.N., Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital;; Rizqa, T., Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital;; Mulansari, N.A., Division of Hematology and Medical Oncology, Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital; Harimurti, K., Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital; |
[No abstract available] |
anticoagulant; COVID-19; thromboprophylaxis.; VTE |
|
Elsevier B.V. |
09248579 |
|
|
Article |
Q1 |
1454 |
2387 |
|
|
203 |
Sasmono R.T., Johar E., Yohan B., Ma’Roef C.N., Soebandrio A., Myint K.S.A., Pronyk P., Hadinegoro S.R., Soepardi E.J., Bouckenooghe A., Hawley W., Rosenberg R., Powers A.M. |
57245712300;57204001174;55843037500;6507740388;8602893200;7003758970;6602466584;57226218772;57191174412;18233281300;7004280510;35578810900;7005770718; |
In Response: Stability of zika virus antibodies in specimens from a retrospective serological study |
2021 |
American Journal of Tropical Medicine and Hygiene |
105 |
3 |
|
853 |
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115293744&doi=10.4269%2fajtmh.21-0564b&partnerID=40&md5=4b5e07961e6006f21355f4fdf73c7fa8 |
Eijkman Institute for Molecular Biology, Jakarta, Indonesia; UNICEF Indonesia, Jakarta, Indonesia; Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Ministry of Health of the Republic of Indonesia, Jakarta, Indonesia; Sanofi Pasteur Lyon, Rhone-Alpes, France; Centers for Disease Control and Prevention, Atlanta, GA, United States; Centers for Disease Control and Prevention Fort, Collins, CO, United States |
Sasmono, R.T., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Johar, E., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Yohan, B., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Ma’Roef, C.N., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Soebandrio, A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Myint, K.S.A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Pronyk, P., UNICEF Indonesia, Jakarta, Indonesia; Hadinegoro, S.R., Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Soepardi, E.J., Ministry of Health of the Republic of Indonesia, Jakarta, Indonesia; Bouckenooghe, A., Sanofi Pasteur Lyon, Rhone-Alpes, France; Hawley, W., Centers for Disease Control and Prevention, Atlanta, GA, United States; Rosenberg, R., Centers for Disease Control and Prevention Fort, Collins, CO, United States; Powers, A.M., Centers for Disease Control and Prevention Fort, Collins, CO, United States |
[No abstract available] |
|
immunoglobulin G antibody; virus antibody; enzyme linked immunosorbent assay; freezing; Letter; plaque reduction neutralization test; serology; storage; Zika virus; human; retrospective study; serodiagnosis; Zika fever; Humans; Neutralization Tests; Retrospective Studies; Zika Virus; Zika Virus Infection |
American Society of Tropical Medicine and Hygiene |
00029637 |
|
34314374 |
Letter |
Q1 |
1015 |
4298 |
|
|