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No records
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321 |
Kalaij A.G.I., Sugiyanto M., Ilham A.F. |
57223906853;57223907058;57223916865; |
Factors Associated With Vaccination Compliance in Southeast Asian Children: A Systematic Review |
2021 |
Asia-Pacific Journal of Public Health |
33 |
5 |
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479 |
488 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106426931&doi=10.1177%2f10105395211014640&partnerID=40&md5=5913c1adcdd2be2c2d07170aba4e2029 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kalaij, A.G.I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sugiyanto, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ilham, A.F., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Although vaccination coverage has reached a peak of 86% globally, around 19.9 million infants and children are yet to receive routine vaccinations—with Asia holding the highest prevalence of noncompliance. This implies notable gaps in vaccination coverage among some regions in the world. This study aims to analyze the factors associated with compliance toward childhood vaccination in Southeast Asia. A systematic review of observational studies was conducted using the following databases: PubMed, Scopus, and Cochrane. Included studies analyze factors affecting compliance with childhood vaccination in Southeast Asia, and assessed with Joanna Briggs Institute (JBI) and Newcastle-Ottawa Scale’s criteria. Sixteen observational studies were included, with a total of 41 956 subjects, consisting of 15 cross-sectional studies and one case-control study. Our results suggested that parental personal–related, children and family status–related, socioeconomic, and health care–related factors strongly affected subjects’ compliance with immunization. Prominent determinants were older maternal age, higher economics groups, parents in government or health care sectors, and frequent antenatal care visits. On the other hand, noncompliance were associated with younger age, large quantity of family members, lower economic groups, lower education, and unemployed parents. We hope that this comprehensive assessment thoroughly addresses challenges and inform strategies to raise compliance toward childhood vaccination in Southeast Asia. © 2021 APJPH. |
childhood vaccination; compliance; factors; Southeast Asia |
case control study; child; childhood; controlled study; cross-sectional study; education; educational status; female; government; health care cost; human; human experiment; infant; male; maternal age; Medline; Newcastle-Ottawa scale; observational study; prenatal care; review; Scopus; Southeast Asia; Southeast Asian; systematic review; unemployment; vaccination; article |
SAGE Publications Inc. |
10105395 |
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34013786 |
Review |
Q2 |
572 |
8837 |
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322 |
Fuady A., Khoe L.C., Azzahra T.B., Lestari H.M., Sutanto R.L., Yo E.C., Suryoadji K.A., Sudarsono N.C., Findyartini A. |
37085331400;56586245200;57223601523;57223631169;57222060277;57213188908;57223633894;57201862518;56543777300; |
Good Knowledge but Poor Practice Toward COVID-19 Among Indonesian Youth |
2021 |
Asia-Pacific Journal of Public Health |
33 |
5 |
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605 |
607 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105912511&doi=10.1177%2f10105395211015048&partnerID=40&md5=eeb26dde9d980d4470234af3a533b0c1 |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Undergraduate Medical Program, Faculty of Medicine, Indonesia; Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Center for Sports and Exercise Studies, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia; Department of Medical Education, Faculty of Medicine, Indonesia |
Fuady, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Khoe, L.C., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Azzahra, T.B., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Lestari, H.M., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Sutanto, R.L., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Yo, E.C., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Suryoadji, K.A., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Sudarsono, N.C., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Center for Sports and Exercise Studies, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia; Findyartini, A., Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia, Department of Medical Education, Faculty of Medicine, Indonesia |
[No abstract available] |
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SAGE Publications Inc. |
10105395 |
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33998316 |
Article |
Q2 |
572 |
8837 |
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No records
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557 |
Della C.D., Teo D.C.L., Agiananda F., Nimnuan C. |
57200945999;57192839106;55644397300;6506165703; |
Culturally informed psychotherapy in Asian consultation-liaison psychiatry |
2021 |
Asia-Pacific Psychiatry |
13 |
1 |
e12431 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092615807&doi=10.1111%2fappy.12431&partnerID=40&md5=1d13ff58ccac52f58bf302293a14868b |
College of Medicine, University of the Philippines Manila, Philippine General Hospital, Manila, Philippines; Department of Psychological Medicine, Changi General Hospital, Duke-NUS Medical School, Singapore; Faculty of Medicine, Department of Psychiatry, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta Pusat, Indonesia; Faculty of Medicine, Chulalongkorn University, Thailand |
Della, C.D., College of Medicine, University of the Philippines Manila, Philippine General Hospital, Manila, Philippines; Teo, D.C.L., Department of Psychological Medicine, Changi General Hospital, Duke-NUS Medical School, Singapore; Agiananda, F., Faculty of Medicine, Department of Psychiatry, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta Pusat, Indonesia; Nimnuan, C., Faculty of Medicine, Chulalongkorn University, Thailand |
Psychotherapy provides substantial benefits for patients with medical illness. Western-based psychotherapies are commonly practiced by consultation-liaison psychiatrists in Asia. Although such interventions benefit Asian patients, they are limited by their cultural applicability. Sociocultural factors shape the meaning, expression, and treatment of medical illnesses. In helping patients with medical problems, it is imperative that psychiatrists be mindful of the value of culture in their clinical work. The concept of the self, religion, spirituality, adaptation, coping, and defense mechanisms are all culturally determined. This article discusses how these concepts impact the practice of psychotherapy in the Asian consultation-liaison psychiatry setting. Currently, there is a dearth of systematic research about this subject matter. Most studies describe the application of Western-based psychotherapies for patients with medical illness with little input as to cultural modifications or implications of such interventions. The authors of this article identify culturally consonant psychotherapeutic techniques in the Asian consultation-liaison psychiatry context. Furthermore, they also propose general guidelines in the cultural adaptation of psychotherapy interventions or development of indigenous psychotherapies. © 2020 John Wiley & Sons Australia, Ltd |
collectivism; consultation-liaison psychiatry; culture; psychotherapy; religion |
adult; article; Asia; Asian; consonant; consultation; defense mechanism; human; liaison psychiatry; practice guideline; psychiatrist; psychotherapy; religion; mental disease; patient referral; procedures; psychotherapy; transcultural care; Asia; Culturally Competent Care; Humans; Mental Disorders; Psychotherapy; Referral and Consultation |
Wiley-Blackwell |
17585864 |
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33073528 |
Article |
Q2 |
654 |
7658 |
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No records
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18 |
Firdaus R., Theresia S., Austin R., Tiara R. |
57423039300;57222095380;57422434500;57422587800; |
Propofol effects in rodent models of traumatic brain injury: A systematic review |
2021 |
Asian Biomedicine |
15 |
6 |
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253 |
265 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123275403&doi=10.2478%2fabm-2021-0032&partnerID=40&md5=fdc2eb2da5eaacf73d60546fd4a9fc72 |
Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Firdaus, R., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Theresia, S., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Austin, R., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Tiara, R., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Background: Traumatic brain injury (TBI) causes high mortality and disability worldwide. Animal models have been developed to explore the complex processes in TBI. Propofol is used to manage head injuries during surgical intervention and mechanical ventilation in patients with TBI. Many studies have investigated the neuroprotective effect of propofol on TBI. However, other studies have shown neurotoxic effects. Objectives: To review systematically the literature regarding the neuroprotective and neurotoxic effects of propofol in rodent models of TBI. Methods: Data from rodents as models of TBI with propofol as one of the intervention agents, and/or comparing the neuroprotective effects of propofol with the other substances in rodent models of TBI, were obtained from PubMed, EBSCO Host, and ProQuest databases. The PRISMA 2020 statement recommendations were followed and research questions were developed based on PICOS guidelines. Data was extracted from the literature using a standardized Cochrane method. Results: We analyzed data from 12 articles on physiological changes of experimental animals before and after trauma, the effects of propofol administration, and the observed neurotoxic effects. The effects of propofol administration were observed in terms of changes in traumatic lesion volume, the release of antioxidants and inflammatory factors, and the neurological function of rodent models of TBI. Conclusion: Propofol has neuroprotective and neurotoxic effects via several mechanisms, and various doses have been used in research to determine its effects. The timing of administration, the dose administered, and the duration of administration contribute to determine the effect of propofol in rodent models of TBI. However, the doses that produce neuroprotective and neurotoxic effects are not yet clear and further research is needed to determine them. © 2021 Riyadh Firdaus et al., published by Sciendo. |
anesthetics; brain injuries, traumatic; neuroprotection; propofol; Rodentia |
calpain; carbon dioxide; catalase; citicoline; diazepam; erythropoietin; fentanyl; glucose; immunoglobulin enhancer binding protein; interleukin 1beta; interleukin 6; isoflurane; ketamine; malonaldehyde; mitogen activated protein kinase p38; morphine; nitric oxide; oxygen; pentobarbital; propofol; semaphorin; superoxide dismutase; tumor necrosis factor; xanthine oxidase; adult; antiinflammatory activity; antioxidant activity; arterial carbon dioxide tension; arterial oxygen tension; blood pH; brain edema; brain injury; Cochrane Library; combination drug therapy; controlled study; core temperature; diffuse brain injury; dose response; drug megadose; female; glucose blood level; head injury; heart rate; hematocrit; lesion volume; lipid peroxidation; low drug dose; male; mean arterial pressur |
Sciendo |
19057415 |
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Review |
Q4 |
178 |
20816 |
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No records
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722 |
Haifa G.Z., Wardoyo S. |
57249982200;57211106608; |
Surgical management in tetralogy of Fallot with rare unilateral pulmonary anomalies: A literature review |
2021 |
Asian Cardiovascular and Thoracic Annals |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114401204&doi=10.1177%2f02184923211039732&partnerID=40&md5=777078337b7532f398e346223b7685f6 |
Training Program of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Haifa, G.Z., Training Program of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Wardoyo, S., Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Tetralogy of Fallot with unilateral pulmonary anomalies such as the unilateral absence of pulmonary artery or unilateral pulmonary agenesis is an extremely rare complex congenital heart anomaly. There is no established surgical algorithm for tetralogy of Fallot with concomitant unilateral pulmonary anomalies. This condition is still challenging, especially in the surgical field. In this review we also present our experiences in our center, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. This literature review aimed to discuss systematic treatment options and hoped to help the decision-making process when surgeons face these rare anomalies. © The Author(s) 2021. |
Tertralogy of Fallot; unilateral absence of pulmonary artery; unilateral pulmonary agenesis; unilateral pulmonary anomalies |
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SAGE Publications Inc. |
02184923 |
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Review |
Q3 |
203 |
19132 |
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792 |
Marwali E.M., Caesa P., Purnama Y., Rayhan M., Budiwardhana N., Fitria L., Fakhri D., Portman M.A. |
36608535400;57204921746;57225291969;57219904946;56805196100;56500669600;8599513100;7004985824; |
Thiamine levels in Indonesian children with congenital heart diseases undergoing surgery using cardiopulmonary bypass machine |
2021 |
Asian Cardiovascular and Thoracic Annals |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107515265&doi=10.1177%2f02184923211024103&partnerID=40&md5=e04e32d473d0075386f8ced87f6df736 |
Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pediatric Cardiac Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Cardiothoracic Surgery Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Marwali, E.M., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Caesa, P., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Purnama, Y., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Rayhan, M., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Budiwardhana, N., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Fitria, L., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Fakhri, D., Pediatric Cardiac Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Pediatric Cardiac Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Portman, M.A., Department of Cardiothoracic Surgery Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: This study evaluated thiamine levels in Indonesian children with congenital heart diseases before and after cardiopulmonary bypass and their relationship with clinical and surgical outcomes. Method: A prospective, single center cross-sectional study was conducted to evaluate thiamine levels in 25 children undergoing congenital heart diseases surgery with cardiopulmonary bypass procedure. Thiamine levels were quantified using a high-performance liquid chromatography method. Result: Preoperative thiamine deficiency was observed in one subject. Thiamine levels did not differ statistically between nutritional status and clinical outcomes categories. There were no significant changes in thiamine levels before and after cardiopulmonary bypass (median pre versus post (P25–75): 50 ng/mL (59.00–116.00) and 83.00 ng/mL (70.00–101.00), p = 0.84), although a significant reduction in thiamine levels were observed with longer cardiopulmonary bypass duration (p = 0.017, R = −0.472). Conclusion: Thiamine levels were not significantly impacted by cardiac surgery except in patients undergoing extremely long cardiopulmonary bypass duration. However, clinical outcome was not affected by thiamine levels. © The Author(s) 2021. |
cardiopulmonary bypass; congenital heart disease; malnutrition; Thiamine |
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SAGE Publications Inc. |
02184923 |
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Article |
Q3 |
203 |
19132 |
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No records
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21 |
Panigoro S.S., Listiyaningsih E., Nurlaila I., Mahesworo B., Hidayat A.A., Budiarto A., Sudigyo D., Amirullah D., Simon S., Baurley J., Pardamean B. |
56790104300;57428355200;57217958627;57211237664;57190939386;57170903800;57219288112;57416872900;57280545200;23388672900;55009925500; |
Intronic Variant of MUTYH Gene Exhibits A Strong Association with Early Onset of Breast Cancer Susceptibility in Indonesian Women Population |
2021 |
Asian Pacific Journal of Cancer Prevention |
22 |
12 |
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3985 |
3991 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123037116&doi=10.31557%2fAPJCP.2021.22.12.3985&partnerID=40&md5=34e035bd72e69ca78f7d440bda975cf2 |
Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Genetics Indonesia, Jakarta, 12940, Indonesia; Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, 11480, Indonesia; School of Computer Science, Bina Nusantara University, Jakarta, 11480, Indonesia; BINUS Graduate Program - Master of Computer Science Program, Bina Nusantara University, Jakarta, 11480, Indonesia |
Panigoro, S.S., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Listiyaningsih, E., Genetics Indonesia, Jakarta, 12940, Indonesia; Nurlaila, I., Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, 11480, Indonesia; Mahesworo, B., Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, 11480, Indonesia; Hidayat, A.A., Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, 11480, Indonesia; Budiarto, A., Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, 11480, Indonesia, School of Computer Science, Bina Nusantara University, Jakarta, 11480, Indonesia; Sudigyo, D., Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, 11480, Indonesia; Amirullah, D., Genetics Indonesia, Jakarta, 12940, Indonesia; Simon, S., Genetics Indonesia, Jakarta, 12940, Indonesia; Baurley, J., Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, 11480, Indonesia; Pardamean, B., Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, 11480, Indonesia, BINUS Graduate Program - Master of Computer Science Program, Bina Nusantara University, Jakarta, 11480, Indonesia |
Objective: Several studies have recently indicated a huge shifting pattern toward early age onset cases in breast cancer (BC) patients. However, the studies exerted relatively limited to the Caucasian population. This preliminary study is aimed to investigate the genetic risk factors for young BC patients specifically in Indonesia population. Methods: DNA samples were extracted from 79 BC patients aged younger than 40 years old and 90 healthy samples. These DNA samples were sequenced using Illumina NextSeq 500 platform and preprocessed to extract the single-nucleotide polymorphisms (SNPs) data. Firstly, multiple univariate logistic regressions were performed to test the association between each SNP and BC incidence in young patients. Furthermore, to analyze the polygenic effects derived from multiple SNPs, we employed a multivariate logistics regression. Results: There were only 15 SNPs passed our 95% call rate threshold thus subsequently were used in the association test. One of these variants, rs3219493, emerged to be significantly associated with early-onset BC (p-value = 0.025, OR = 3.750, 95% CI = 1.178-11.938). This result is consistent with the multivariate logistic regression model, where the pertinent variant was found statistically significant (p-value = 0.008, OR = 8.398, 95% CI = 1.720-40.920). This variant was identified as an intronic variant within MUTYH gene which has been reported in several published studies to exhibit an association with the incidence of breast cancer in China, Italy and Sephardi Jews population. However, there is no evident this gene impacting the risk of developing early onset of BC in Indonesia population. Conclusion: Despite our limitation in terms of sample size analyzed in this preliminary study, our finding on significant association of intronic MUTHY with the early onset of BC in Indonesia led to a broadened insight of population-based unique aspect to being taken into an in-depth account for and advancement of chemotherapy. © 2021. All Rights Reserved. |
Breast cancer- MUTYH- early onset- Indonesia |
DNA glycosylase MutY; DNA glycosyltransferase; adult; Asian; breast tumor; case control study; ethnology; female; genetic predisposition; genetics; human; incidence; Indonesia; single nucleotide polymorphism; statistical model; Adult; Asians; Breast Neoplasms; Case-Control Studies; DNA Glycosylases; Female; Genetic Predisposition to Disease; Humans; Incidence; Indonesia; Logistic Models; Polymorphism, Single Nucleotide |
Asian Pacific Organization for Cancer Prevention |
15137368 |
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34967580 |
Article |
Q2 |
512 |
9866 |
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352 |
Kristin E., Endarti D., Khoe L.C., Taroeno-Hariadi K.W., Trijayanti C., Armansyah A., Sastroasmoro S. |
6504458442;56626162000;56586245200;37012289000;57203727260;57225098604;6507794136; |
Economic Evaluation of Adding Bevacizumab to Chemotherapy for Metastatic Colorectal Cancer (mCRC) Patients in Indonesia |
2021 |
Asian Pacific Journal of Cancer Prevention |
22 |
6 |
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1921 |
1926 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109162811&doi=10.31557%2fAPJCP.2021.22.6.1921&partnerID=40&md5=8b230f77f7dbd1e3652b63db9226b4c0 |
Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Department of Pharmaceutics, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Respira Hospital, Yogyakarta, Indonesia; Center of Financing and Health Insurance, Ministry of Health, Government of Indonesia, Indonesia; Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kristin, E., Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Endarti, D., Department of Pharmaceutics, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia; Khoe, L.C., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Taroeno-Hariadi, K.W., Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Trijayanti, C., Respira Hospital, Yogyakarta, Indonesia; Armansyah, A., Center of Financing and Health Insurance, Ministry of Health, Government of Indonesia, Indonesia; Sastroasmoro, S., Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: Since 2016, bevacizumab has been widely used to treat metastatic colorectal cancer (mCRC) in Indonesia. Nevertheless, the high cost of bevacizumab has raised the question of whether the therapy is considered cost-effective and should be included in the national health insurance system. This study aimed to assess the cost-effectiveness of bevacizumab plus chemotherapy versus chemotherapy alone for the treatment of mCRC patients. Methods: A Markov model was applied using the perspective of the Indonesian healthcare system to assess cost-effectiveness. The health outcomes were expressed in terms of quality-adjusted life years (QALY) using the validated EuroQoL-5D-5L instrument. Data for medical costs were collected from hospital billings in four hospitals located in three different cities in Indonesia. Meanwhile, data for utility were obtained from interviewing 90 patients who came to the hospital. We compared those mCRC patients who received chemotherapy alone either with FOLFOX or FOLFIRI, versus patients who received the addition of bevacizumab. Results: With the perspective of societal, the incremental cost-effectiveness ratio (ICER) of adding bevacizumab was USD 49,312 per QALY gained using secondary data and USD 28,446 per QALY using real world data. Conclusion: Using either a healthcare or societal perspective, the addition of bevacizumab for mCRC treatment was considered not cost-effective. © 2021. All Rights Reserved. |
Metastatic colorectal cancer- bevacizumab- chemotherapy |
antineoplastic agent; bevacizumab; camptothecin; fluorouracil; folinic acid; platinum complex; colorectal tumor; cost benefit analysis; economics; human; Indonesia; Markov chain; metastasis; pathology; quality adjusted life year; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colorectal Neoplasms; Cost-Benefit Analysis; Fluorouracil; Humans; Indonesia; Leucovorin; Markov Chains; Neoplasm Metastasis; Organoplatinum Compounds; Quality-Adjusted Life Years |
Asian Pacific Organization for Cancer Prevention |
15137368 |
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34181352 |
Article |
Q2 |
512 |
9866 |
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674 |
Sobri F.B., Bachtiar A., Panigoro S.S., Ayuningtyas D., Gustada H., Yuswar P.W., Nur A.A., Putri R.C.R.A., Widihidayati A.D. |
57217500979;56683183900;56790104300;56461361200;57195940157;57253490900;57328088400;57328181200;57328088500; |
Factors Affecting Delayed Presentation and Diagnosis of Breast Cancer in Asian Developing Countries Women: A Systematic Review |
2021 |
Asian Pacific Journal of Cancer Prevention |
22 |
10 |
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3081 |
3092 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118798481&doi=10.31557%2fAPJCP.2021.22.10.3081&partnerID=40&md5=6febc7b64c7dfeddec8aeff299b230ac |
Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Department of Health Policy and Administration, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pondok Indah Hospital, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia |
Sobri, F.B., Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Bachtiar, A., Department of Health Policy and Administration, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Panigoro, S.S., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ayuningtyas, D., Department of Health Policy and Administration, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Gustada, H., Pondok Indah Hospital, Jakarta, Indonesia; Yuswar, P.W., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Nur, A.A., Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Putri, R.C.R.A., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Widihidayati, A.D., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia |
Background: Advance in screening strategies and management had steadily decreased the mortality rates of breast cancer. In developing countries, conducting screening and early diagnosis of breast cancers may face several problems. This systematic review aims to determine factors affecting the delayed diagnosis of breast cancer in developing countries in Asia. Methods: Literature research was conducted through Pubmed, ScienceDirect, Scopus, EbscoHost, Cochrane Library, and Google Scholar. The main keywords were “breast cancer”, “delayed diagnosis” and “developing countries”. Both quantitative and qualitative studies were included. Results: A total of 26 studies were included. The definition of delayed presentation or diagnosis varied from 1 month to 6 months. Among all the factors from patients and providers, breast symptoms and examinations consistently showed a significant contribution in reducing delayed diagnosis. Strengthened by qualitative studies, patients’ knowledge and perception also had a major role in delayed diagnosis. Conclusion: Among Asian developing countries, breast symptoms and examination, as well as individual knowledge and perception, are the main factors related to delayed diagnosis of breast cancer. © 2021. All Rights Reserved. |
Asian developing countries; breast cancer; delayed diagnosis; delayed presentation; examination; knowledge |
Asia; Asian; attitude to health; breast tumor; delayed diagnosis; developing country; female; human; symptom assessment; time factor; Asia; Asians; Breast Neoplasms; Delayed Diagnosis; Developing Countries; Female; Health Knowledge, Attitudes, Practice; Humans; Symptom Assessment; Time Factors |
Asian Pacific Organization for Cancer Prevention |
15137368 |
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34710982 |
Article |
Q2 |
512 |
9866 |
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