No records
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205 |
Krisanti E.A., Gofara T.Z., Rahyussalim A.J., Mulia K. |
14019920500;57260804700;55212166100;6507666535; |
Polyvinyl alcohol (PVA)/chitosan/sodium tripolyphosphate (STPP) hydrogel formulation with freeze-thaw method for anti-tuberculosis drugs extended release |
2021 |
AIP Conference Proceedings |
2370 |
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020010 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115001335&doi=10.1063%2f5.0063175&partnerID=40&md5=a3c9afce6e9d9f6305976a87eb3a4790 |
Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Krisanti, E.A., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Gofara, T.Z., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Rahyussalim, A.J., Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Mulia, K., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia |
Tuberculosis (TB) is one of the infectious diseases which must be routinely oral treated with anti-tuberculosis drugs performed 12-24 months. With treatment using drug implans that can release TB drugs in a longer time in the target location, it will be more effective, because the drug will be close to the target and go directly into the blood. In this study, the PVA / chitosan / STPP hydrogel formulation loaded with 4 types of anti-tuberculosis drugs (isoniazid, ethambutol, pirazinamide, and rifampicin) made using the freeze-thaw method. It is obtained that chitosan addition up until 20% could reduce drug's release rate and hold drug's release until 30 days, but the effect of STPP addition could not be seen because the ammount added is too small which is also shown from FTIR study that there is no STPP in the hydrogel detected. 80% PVA-20% Chitosan- 2% STPP hydrogel formulation release TB drugs the slowest and extended on Isoniazid, Ethambutol, and Rifampicin. SEM study shown that chitosan addition in PVA hydrogel resulted a homogen solution, and hydrogel with densely folded surface. 2% STPP addition resulted in smoother, more homogenous, and smaller pores morphology. © 2021 Author(s). |
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American Institute of Physics Inc. |
0094243X |
9780735441262 |
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Conference Paper |
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177 |
20880 |
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207 |
Kartini D., Panigoro S.S., Ham M.F., Harahap A.S., Rasyid S.H., Marcevianto K.V. |
57215490523;56790104300;57257336600;57218511857;57224779056;57256764400; |
Thyroid hemiagenesis associated with Hurthle cell carcinoma: A case report |
2021 |
International Journal of Surgery Case Reports |
86 |
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106372 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114820796&doi=10.1016%2fj.ijscr.2021.106372&partnerID=40&md5=a842dbe995f6b1a20d9b986dad8aad97 |
Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Pathological Anatomy, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Kartini, D., Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Panigoro, S.S., Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Ham, M.F., Department of Pathological Anatomy, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Harahap, A.S., Department of Pathological Anatomy, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Rasyid, S.H., Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Marcevianto, K.V., Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Introduction and importance: Thyroid hemiagenesis (TH) is a rare congenital anomaly where one lobe fails to develop, especially more frequently occurs on the left lobe. The exact mechanisms for thyroid morphogenesis remain unclear. In this paper, we report a rare case of right lobe TH associated with Hurthle cell carcinoma. Case presentation: A 59 years old woman was admitted with a neck lump increasing in size in the last 20 years. There were no symptoms of hyperthyroidism and hypothyroidism. There was a palpable, painless 5 cm mass in the middle of the neck. Initial thyroid ultrasonography (USG) revealed an enlarged left lobe, with hypoechoic lesion with cystic component and calcification (TIRADS 4). However, the right lobe was non-visualized. Fine needle aspiration biopsy result tendency was a malignancy. Hence, isthmolobectomy was conducted. Pathology result was Hurthle cell carcinoma. On the ninth month, USG revealed fibrotic tissue in the right thyroid bed and bilateral lymphadenopathy. Due to discrepancy, the patient was planned for a neck exploration surgery and a right lobe incision. Intraoperatively, the right thyroid was absent. Intraoperative USG also confirmed no right thyroid lobe. Discussion: Thyroid hemiagenesis can be visualized by using USG due to its practicality and cost effectiveness reasons. Follow up evaluations consisted of systematic monitoring of thyroid morphology and hormonal functions should follow the diagnosis of TH. Neck exploration surgery might need to be performed to clarify any discrepancy and confirm the diagnosis. Conclusion: TH can be recognized through supporting examination; however, discrepancy may occur. © 2021 The Authors |
Hurthle cell carcinoma; Neck exploration surgery; Thyroid hemiagenesis |
euthyrax; levothyroxine sodium; thyroglobulin; adult; Article; calcification; cancer diagnosis; cancer size; cancer surgery; case report; clinical article; color Doppler flowmetry; echography; female; fine needle aspiration biopsy; frozen section; histopathology; human; human tissue; incision; isthmolobectomy; lobectomy; lymph node; lymphadenopathy; middle aged; neck; neck tumor; parathyroid gland; physical examination; recurrent laryngeal nerve; thyroglobulin blood level; thyroid carcinoma; thyroid dysgenesis; thyroid hemiagenesis; thyroid lobe; thyroid parafollicular cell; thyroid surgery; vascularization; vein ligation |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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208 |
Widodo D.W., Mars R., Suwento R., Alviandi W., Oriza I.I.D., Bardosono S. |
56644646600;57248384300;55743638800;57189731254;57205092885;21933841000; |
Satisfaction and health-related quality of life of patients with microtia following reconstructive surgery using the Nagata technique |
2021 |
PLoS ONE |
16 |
9 September |
e0256652 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114383156&doi=10.1371%2fjournal.pone.0256652&partnerID=40&md5=3f7c84ef725b34720da5ae494a0fc02a |
Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Faculty of Psychology, Universitas Indonesia, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Widodo, D.W., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Mars, R., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Suwento, R., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Alviandi, W., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Oriza, I.I.D., Faculty of Psychology, Universitas Indonesia, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Objective This study aimed to investigate the functional outcomes, satisfaction, and quality of life of patients with microtia following reconstructive surgery. Methods This cross-sectional study was conducted using retrospective data of patients with microtia following reconstructive surgery using the Nagata technique. Data were obtained from the medical records of patients who underwent reconstructive surgery at the Division of Facial Plastic and Reconstructive Surgery, Department of Otorhinolaryngology, Head and Neck Surgery, Dr. Cipto Mangunkusumo Hospital between 2014 and 2018. All eligible patients were referred to participate in this study between November 2018 and March 2019. The hearing function was assessed by a professional audiologist after surgery. Patient satisfaction was evaluated by interview using a previously developed questionnaire, while quality of life was assessed using the EuroQol-5D-Young questionnaire. Results Thirty-one eligible subjects were included in the study. Pain and discomfort were the most commonly reported factors related to the quality of life following surgery. Approximately 67.7% of the patients were satisfied; 19.4% were very satisfied, and 12.9% reported acceptance of their surgical outcomes. The most common complication was infection (n = 8). Most patients did not experience any problems in their lives after microtia surgery. Conclusions The highest rate of satisfactory outcomes was observed for the lobule subunit, which was assumed to be associated with the use of the Z-plasty technique. The most common complication was infection, as environmental hygiene was the most important factor. Thus, further concern for maintaining good hygiene is necessary to improve the quality of reconstructive surgery. The level of satisfaction with microtia reconstructive surgery was adequate. Most patients had a good health-related quality of life without experiencing any problems. © 2021 Widodo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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adolescent; Article; audiologist; child; clinical article; cross-sectional study; ear infection; European Quality of Life 5 Dimensions questionnaire; female; hearing; human; interview; male; medical record; microtia; otalgia; patient referral; patient satisfaction; quality of life; questionnaire; reconstructive surgery; retrospective study; external ear; microtia; patient satisfaction; procedures; psychology; reconstructive surgery; treatment outcome; Adolescent; Child; Congenital Microtia; Cross-Sectional Studies; Ear, External; Female; Humans; Male; Patient Satisfaction; Quality of Life; Reconstructive Surgical Procedures; Retrospective Studies; Treatment Outcome |
Public Library of Science |
19326203 |
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34469475 |
Article |
Q1 |
990 |
4434 |
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210 |
Nurhayati R.W., Cahyo R.D., Pratama G., Anggraini D., Mubarok W., Kobayashi M., Antarianto R.D. |
55748436600;57212460506;57195959221;57221606578;57208440063;20835016200;57190862806; |
Alginate-chitosan microencapsulated cells for improving cd34+ progenitor maintenance and expansion |
2021 |
Applied Sciences (Switzerland) |
11 |
17 |
7887 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114106674&doi=10.3390%2fapp11177887&partnerID=40&md5=8aa18a5d52c69e6eb72dcb38252f4489 |
Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Prof. Soemantri Brojonegoro, Kampus UI, Depok, 16424, Indonesia; Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia; Department of Biotechnology, Faculty of Engineering, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan; Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jl. Diponegoro No. 71, Central Jakarta, 10430, Indonesia; Integrated Service Unit of Stem Cell Medical Technology (IPT TK Sel Punca), Dr. Cipto Mangunkusumo General Hospital (RSCM), Jl. Diponegoro No. 71, Salemba, Central Jakarta, 10430, Indonesia; Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka, 560-8531, Japan; Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia |
Nurhayati, R.W., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Prof. Soemantri Brojonegoro, Kampus UI, Depok, 16424, Indonesia, Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia; Cahyo, R.D., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Department of Biotechnology, Faculty of Engineering, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan; Pratama, G., Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jl. Diponegoro No. 71, Central Jakarta, 10430, Indonesia, Integrated Service Unit of Stem Cell Medical Technology (IPT TK Sel Punca), Dr. Cipto Mangunkusumo General Hospital (RSCM), Jl. Diponegoro No. 71, Salemba, Central Jakarta, 10430, Indonesia; Anggraini, D., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Division of Materials Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Mubarok, W., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama-cho, Toyonaka, Osaka, 560-8531, Japan; Kobayashi, M., Division of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, 630-0192, Japan; Antarianto, R.D., Stem Cells & Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia, Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, 10430, Indonesia |
Protocols for isolation, characterization, and transplantation of hematopoietic stem cells (HSCs) have been well established. However, difficulty in finding human leucocyte antigens (HLA)-matched donors and scarcity of HSCs are still the major obstacles of allogeneic transplanta-tion. In this study, we developed a double-layered microcapsule to deliver paracrine factors from non-matched or low-matched HSCs to other cells. The umbilical cord blood-derived hematopoietic progenitor cells, identified as CD34+ cells, were entrapped in alginate polymer and further protected by chitosan coating. The microcapsules showed no toxicity for surrounding CD34+ cells. When CD34+ cells-loaded microcapsules were co-cultured with bare CD34+ cells that have been collected from unrelated donors, the microcapsules affected surrounding cells and increased the percentage of CD34+ cell population. This study is the first to report the potency of alginate-chitosan microcap-sules containing non-HLA-matched cells for improving proliferation and progenitor maintenance of CD34+ cells. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Alginate; CD34; Chitosan; Hematopoietic; Megakaryocyte; Microencapsulation; Progenitor; Proliferation; Stem cells |
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MDPI |
20763417 |
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Article |
Q2 |
435 |
11324 |
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211 |
Angelin T.C., Bardosono S., Shinta D., Fahmida U. |
57235777300;21933841000;57237520500;14420783500; |
Growth, dietary intake, and vitamin D receptor (VDR) promoter genotype in Indonesian school-age children |
2021 |
Nutrients |
13 |
9 |
2904 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113740878&doi=10.3390%2fnu13092904&partnerID=40&md5=c7a37360e57bb2d193a5b68571b677d7 |
Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia |
Angelin, T.C., Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional, Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Nutrition, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia—Dr. Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Shinta, D., Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional, Universitas Indonesia, Jakarta, 10430, Indonesia; Fahmida, U., Southeast Asian Ministers of Education Organization Regional Center for Food and Nutrition (SEAMEO RECFON)-Pusat Kajian Gizi Regional, Universitas Indonesia, Jakarta, 10430, Indonesia |
Nutrition has been known as a predominant factor associated with stunting. However, some studies have discovered a genetic contribution in calcium absorption that will affect growth, known as the VDR gene. The aim of this study was to assess the association between VDR gene polymorphism and dietary intake towards height-for-age z-score (HAZ) of elementary school children in Malang District, East Java. This study analyzed the baseline of a randomized trial in East Java, Indonesia. School children aged 8–10 years old (n = 142) were included in this study. Energy, protein, calcium, and vitamin D intakes were obtained using 4-day 24-h dietary recalls. Two SNPs located in the promoter region of VDR gene were selected (rs11568820 and rs4516035) and analyzed using Real-Time PCR. The result showed a significant correlation between energy and protein intake with HAZ of the children (p = 0.030 and p = 0.016, respectively). The association between VDR gene and HAZ was not found (p > 0.05). Adjusted by other factors, protein intake was significantly correlated with HAZ (β = 0.034, 95% CI 0.015–0.052, p < 0.001, adj. R2 = 0.089). The children in our study had a favorable VDR gene genotype, however the effect of VDR gene promoter activity might not be revealed due to very low vitamin D and calcium intake to stimulate intestinal calcium absorption which in turn affects HAZ. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Calcium; Children; Dietary intake; Height-for-age z-score (HAZ); Indonesia; Stunting; VDR gene; Vitamin D |
calcium; DNA; protein; vitamin D; vitamin D receptor; calcitriol receptor; vitamin D; Article; body height; calcium absorption; calcium intake; caloric intake; child; child growth; controlled study; correlational study; cross-sectional study; diarrhea; dietary intake; elementary student; female; food frequency questionnaire; gene frequency; genetic variability; genotype; helminthiasis; heterozygote; human; Indonesia; macronutrient intake; male; micronutrient intake; pathogenesis; prevalence; primary school; promoter region; protein intake; randomized controlled trial; real time polymerase chain reaction; respiratory tract infection; school child; semi quantitative food frequency questionnaire; single nucleotide polymorphism; stunting; sun exposure; sunlight; vitamin intake; administration |
MDPI |
20726643 |
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34578782 |
Article |
Q1 |
1418 |
2497 |
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213 |
La Distia Nora R., Putera I., Khalisha D.F., Septiana I., Sitompul R. |
56001881000;56485949000;57219417896;57219417256;8312163900; |
The diagnostic value of polymerase chain reaction for ocular tuberculosis diagnosis in relation to antitubercular therapy response: a meta-analysis |
2021 |
International Journal of Infectious Diseases |
110 |
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394 |
402 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113172042&doi=10.1016%2fj.ijid.2021.07.075&partnerID=40&md5=2517c80887d20c78446a294388261c14 |
Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia; Department of Immunology, Erasmus Medical Center, Rotterdam, Netherlands; University of Indonesia Hospital (RSUI), Depok, West Java, Indonesia |
La Distia Nora, R., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia, Department of Immunology, Erasmus Medical Center, Rotterdam, Netherlands, University of Indonesia Hospital (RSUI), Depok, West Java, Indonesia; Putera, I., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia; Khalisha, D.F., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia; Septiana, I., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia; Sitompul, R., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia |
Background: Polymerase chain reaction (PCR) is currently considered the method of choice for diagnosing ocular tuberculosis. However, the sensitivity and specificity of PCR using ocular samples remain uncertain. Our meta-analysis aimed to review the diagnostic accuracy of PCR testing in confirming ocular tuberculosis, with responses to antitubercular therapy (ATT) as reference indices. Methods: A systematic literature search of the PubMed, EBSCOHost, Scopus, and Google Scholar databases was performed using the standardized PRISMA guideline. Observational studies reporting both PCR MTb positivity and ATT response were included. Meta-analysis was performed to estimate the pooled positivity rate, sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratios (DOR), and summary receiver operating curves (SROC). Results: The pooled positivity rate for PCR MTb was 0.55 (95% CI 0.44–0.67). The overall sensitivity and specificity were 88% (95% CI 83–92) and 71% (95% CI 60–80), respectively. The pooled DOR was 12.15 (95% CI 5.55–26.62). The area under the SROC was 0.83. Conclusions: The diagnostic accuracy of PCR Mtb is not sufficient for use as a benchmark for ocular TB diagnosis routinely based on ATT response. A negative result may help avoid prescribing unnecessary ATT in dilemmatic cases. © 2021 The Author(s) |
Diagnostic accuracy; Mycobacterium tuberculosis; polymerase chain reaction; uveitis |
ethambutol; ethambutol plus isoniazid plus pyrazinamide plus rifampicin; isoniazid; isoniazid plus rifampicin; pyrazinamide; rifampicin; steroid; tuberculostatic agent; tuberculostatic agent; antibiotic therapy; Article; controlled study; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; false negative result; false positive result; human; inflammation; meta analysis; nonhuman; ocular tuberculosis; polymerase chain reaction; quantitative analysis; receiver operating characteristic; recurrent disease; regression analysis; sensitivity and specificity; serpiginous choroiditis; steroid therapy; systematic review; treatment duration; treatment response; genetics; Mycobacterium tuberculosis; polymerase chain reaction; tuberculosis; Antitubercular Agents; Humans; Mycobacteriu |
Elsevier B.V. |
12019712 |
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34364996 |
Article |
Q1 |
1278 |
2980 |
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217 |
Kurnia K.H., Elvioza, Sidik M., Sari T.T., Prihartono J., Sitorus R.S. |
57222405280;57205416912;56252760000;36519483600;6602605635;57221587271; |
Novel retinal findings in β-thalassemia major: older age and higher ferritin level as the risk factors |
2021 |
Graefe's Archive for Clinical and Experimental Ophthalmology |
259 |
9 |
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2633 |
2641 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102635685&doi=10.1007%2fs00417-021-05141-z&partnerID=40&md5=bf7abc1182072dd50cdf5ec7be6fa742 |
Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Kurnia, K.H., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Elvioza, Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Sidik, M., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Sari, T.T., Department of Child Health, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Prihartono, J., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sitorus, R.S., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Purpose: To investigate retinal changes in β-thalassemia major patients and identify their association with systemic risk factors. Methods: In this prospective study, 120 β-thalassemia major patients received complete ophthalmic examinations (best-corrected visual acuity, contrast sensitivity, color vision, and indirect ophthalmoscopy) and retinal imaging using color fundus photography and fundus autofluorescence imaging. Patients were grouped according to the presence of thalassemia-related retinal changes. The association between systemic risk factors (age, type and duration of iron chelator use, history of splenectomy, hemoglobin level, and ferritin level) and thalassemia-related retinal changes was investigated using logistic regression analysis. Results: Thalassemia-related retinal changes were identified in 36.7% of patients. Several distinct retinal changes were observed, including retinal refractile bodies in 10% of patients and retinal hemorrhage in 5.8% of patients. Fundus autofluorescence imaging showed abnormal patterns in 36.3% of patients with thalassemia-related retinal changes and 18.4% of patients without thalassemia-related retinal changes. Age (odds ratio [OR] = 1.10, 95% confidence interval [CI] 1.03–1.18) and ferritin level (OR 1.16, 95% CI 1.01–1.33) were associated with thalassemia-related retinal changes. Conclusion: Novel retinal changes were observed in β-thalassemia major patients. This study identified older age and higher ferritin level as risk factors for thalassemia-related retinal changes. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
Ferritin; Fundus autofluorescence imaging; Iron chelator; Retinal changes; β-Thalassemia major |
deferasirox; deferiprone; deferoxamine; ferritin; hemoglobin; ferritin; adult; age; angioid streak; Article; autofluorescence imaging; best corrected visual acuity; blood transfusion; branch retinal vein occlusion; color vision; contrast sensitivity; controlled study; drusen; epithelium hyperplasia; eye fundus; eye photography; female; ferritin blood level; hemoglobin blood level; human; Indonesia; major clinical study; male; melanocytosis; observational study; ophthalmoscopy; optic disk anomaly; optical coherence tomography; papilledema; patient history of surgery; prospective study; retina disease; retina examination; retina hemorrhage; retina pigment degeneration; slit lamp microscopy; splenectomy; subretinal neovascularization; thalassemia major; treatment duration; aged; beta thalasse |
Springer Science and Business Media Deutschland GmbH |
0721832X |
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33738624 |
Article |
Q1 |
1196 |
3322 |
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218 |
Fachniadin A., Widi Nugroho S., Ananda Aman R., Ichwan S., Tandian D., Susanto E., Watanabe K., Nonaka Y. |
57222123314;57219659664;57222125502;57192906639;57192891173;57204423225;55704851200;36344004800; |
A Dumbbell-shaped hypoglossal schwannoma managed by a combination of open surgery and endoscopic assistance |
2021 |
Interdisciplinary Neurosurgery: Advanced Techniques and Case Management |
25 |
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101102 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101531664&doi=10.1016%2fj.inat.2021.101102&partnerID=40&md5=aa132c91fdc36c35a156948ab70bdf91 |
Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Neurosurgery, Tokyo Jikei University School of Medicine, Tokyo, Japan; Department of Neurosurgery, Tokai University School of Medicine, Tokyo, Japan |
Fachniadin, A., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Widi Nugroho, S., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ananda Aman, R., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ichwan, S., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Tandian, D., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Susanto, E., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Watanabe, K., Department of Neurosurgery, Tokyo Jikei University School of Medicine, Tokyo, Japan; Nonaka, Y., Department of Neurosurgery, Tokai University School of Medicine, Tokyo, Japan |
Background: Hypoglossal schwannoma is a rare benign tumor that comprises about 5% of all intracranial schwannoma. Surgical management for hypoglossal schwannoma is still evolving along with our understanding of neuroanatomy and surgical equipment improvement, especially endoscopy. The far lateral transcondylar approach is commonly used for hypoglossal schwannomas. This traditional approach requires great effort and is considered a lengthy procedure. The use of endoscopy gives an additional advantage to microscopic surgery in managing this tumor, making surgery less complicated and faster. Combining the microscope and endoscope is an effective way to operate in small corridors. Case: In a stepwise fashion, we present a case of a 53-year-old female with hypoglossal schwannoma, which was successfully resected using a retrosigmoid transcondylar approach with endoscopic assistance. Conclusion: A retrosigmoid transcondylar approach with endoscopic assistance is an excellent option in surgical management for hypoglossal schwannoma. Both microscopic and endoscopic approaches will be gaining more usefulness in managing skull base tumors and should be used collaboratively. © 2021 The Authors |
Dumbbell-shaped; Endoscopic; Hypoglossal schwannoma; Retrosigmoid transcondylar |
corticosteroid; fibrin glue; accessory nerve; adult; Article; brain stem; breathing exercise; cancer surgery; case report; cerebral revascularization; chemodectoma; chondroma; clinical article; clinical examination; cranial nerve; craniotomy; differential diagnosis; Doppler flowmetry; drinking; dysphagia; eating; female; histopathology; hoarseness; hospital discharge; human; hypoglossal nerve; intraoperative monitoring; intraoperative neurophysiological monitoring; jugular foramen; liquorrhea; mastoid; medulla oblongata; meningioma; middle aged; mitosis rate; muscle atrophy; neurilemoma; neuroanatomy; neuroendoscopy; neuroimaging; neuromonitoring; neurorehabilitation; nuclear magnetic resonance imaging; open surgery; paraganglioma; paralysis; parapharyngeal space; periosteum; physical exam |
Elsevier B.V. |
22147519 |
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Article |
Q4 |
202 |
19207 |
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219 |
Amarra M.S., Chong M.F.-F., Titapant V., Somprasit C., Rogacion J., Irwinda R., Huynh T.N.K., Nalliah S. |
26024123300;16302916300;6602085502;8440614700;6508291071;57205713130;57221814418;25422423000; |
ILSI Southeast Asia symposium: prevalence, risk factors, and actions to address gestational diabetes in selected Southeast Asian countries |
2021 |
European Journal of Clinical Nutrition |
75 |
9 |
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1303 |
1308 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100287487&doi=10.1038%2fs41430-020-00838-6&partnerID=40&md5=968eff6db95c2d745843171831db19e3 |
Department of Food Science and Nutrition, College of Home Economics, University of the Philippines Diliman, Quezon, Philippines; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore; Department of Obstetrics and Gynecology, Faculty of Medicine, Siriraj Hospital Mahidol University, Bangkok, Thailand; Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Bangkok, Thailand; Department of Pediatrics, University of the Philippines, Manila, Philippines; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Pham Ngoc Thach University of Medicine, Ho Chi Minh, Viet Nam; Division of Obstetrics & Gynaecology, Clinical School, International Medical University, Seremban, Malaysia |
Amarra, M.S., Department of Food Science and Nutrition, College of Home Economics, University of the Philippines Diliman, Quezon, Philippines; Chong, M.F.-F., Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore; Titapant, V., Department of Obstetrics and Gynecology, Faculty of Medicine, Siriraj Hospital Mahidol University, Bangkok, Thailand; Somprasit, C., Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Bangkok, Thailand; Rogacion, J., Department of Pediatrics, University of the Philippines, Manila, Philippines; Irwinda, R., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Huynh, T.N.K., Department of Obstetrics and Gynecology, Pham Ngoc Thach University of Medicine, Ho Chi Minh, Viet Nam; Nalliah, S., Division of Obstetrics & Gynaecology, Clinical School, International Medical University, Seremban, Malaysia |
[No abstract available] |
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trace element; anthropometry; Brunei Darussalam; Cambodia; diet therapy; dietary intake; female; gestational weight gain; health care planning; human; Indonesia; Laos; Malaysia; Myanmar; nutritional assessment; Philippines; physical activity; practice guideline; pregnancy diabetes mellitus; prevalence; Review; risk factor; risk reduction; Singapore; Southeast Asian; symposium; Thailand; Viet Nam; pregnancy; pregnancy diabetes mellitus; Southeast Asia; Asia, Southeastern; Diabetes, Gestational; Female; Humans; Pregnancy; Prevalence; Risk Factors |
Springer Nature |
09543007 |
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33531635 |
Review |
Q1 |
1024 |
4241 |
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224 |
Putra M.A., Sukardi R., Grantomo J., Pratita J. |
57215605850;56610228000;57211348862;57211348842; |
Conventional Repair of an Intraoperatively Diagnosed Congenitally Corrected Transposition of the Great Arteries in an Adult |
2021 |
The heart surgery forum |
24 |
4 |
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E769 |
E771 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117623116&doi=10.1532%2fhsf.3249&partnerID=40&md5=faae8b41db48824f15e78454a9e2e2b0 |
Thoracic and Cardiovascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Indonesia; Integrated Cardiovascular Service, Cipto Mangunkusumo Hospital, Indonesia |
Putra, M.A., Thoracic and Cardiovascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Indonesia; Sukardi, R., Integrated Cardiovascular Service, Cipto Mangunkusumo Hospital, Indonesia; Grantomo, J., Thoracic and Cardiovascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Indonesia; Pratita, J., Thoracic and Cardiovascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Indonesia |
BACKGROUND: Congenitally corrected transposition of the great arteries (ccTGA) is a rare condition that accounts for just 1% of all congenital heart disease. Diagnosis of ccTGA often is missed in adulthood, despite imaging and cardiology consultation. CASE REPORT: We present the case of an intraoperatively diagnosed ccTGA with severe tricuspid valve regurgitation and secundum atrial septal defect in a 54-year-old woman, who preoperatively was diagnosed with mitral valve regurgitation in atrioventricular and ventriculoarterial concordance heart. Intraoperatively, options considered were anatomical repair with atrial-arterial double switch operation after retraining the left ventricle or a conventional repair that focused on the associated defects without addressing the discordant connections. Considering our patient's age and condition, we decided to carry on with the conventional repair to prevent further systemic right ventricle dysfunction that may lead to poor outcome and decreased survival. She was discharged one week after surgery and resumed her normal activity at 3-month follow up. CONCLUSION: Although it rarely happens, CHD such as ccTGA in an adult must always be considered. Careful examination is essential. The treatment of ccTGA in an adult is challenging, with more limited options compared with pediatric patients. However, early management could still provide favorable outcomes. |
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case report; complication; female; heart septum defect; human; intraoperative period; middle aged; tricuspid valve regurgitation; Congenitally Corrected Transposition of the Great Arteries; Female; Heart Septal Defects, Atrial; Humans; Intraoperative Period; Middle Aged; Tricuspid Valve Insufficiency |
NLM (Medline) |
15226662 |
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34473046 |
Article |
Q3 |
255 |
16479 |
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