No records
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510 |
Rahyussalim A.J., Marsetio A.F., Kurniawati T. |
55212166100;57192180884;55213290600; |
Rod and screw corrective manipulation technique, an alternative technique for rigid and severe scoliosis correction management |
2021 |
AIP Conference Proceedings |
2344 |
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050022 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103484021&doi=10.1063%2f5.0047983&partnerID=40&md5=a08a9b1f3ede725651914e30e3021176 |
Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10320, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia |
Rahyussalim, A.J., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10320, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Marsetio, A.F., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10320, Indonesia; Kurniawati, T., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia |
The terms correction and manipulation in the surgical management of scoliosis define a harmonization of several measures performed individually or simultaneously to realign a deformed spine into its normal state on sagittal or coronal views. Scoliosis surgical procedures are modified due to the fact that they are complex procedures with frequent complications and unsatisfactory surgical outcomes. This technique combines rod and screws corrective manipulations applied to each vertebral segment according to the pathobiomechanic state of the deformity to simplify the manipulation process and achieve a good surgical outcome. A preliminary experimental study was done on modifications to the screw application technique, rod application for vertebral segment maneuver techniques during manipulation, and connecting rod use. Surgical outcomes were compared between the rod and screw corrective manipulation (RSCM) and conventional techniques in patients who underwent corrective surgery for scoliosis. Twelve scoliosis patients who underwent the RSCM technique had better complication rates, operative time, estimated blood loss, length of hospital stay, and sagittal alignment correction outcome compared with the 15 scoliosis patients who underwent surgery via the conventional technique. The RSCM technique was not complex, and it was easy to apply and provided better corrective outcomes. Hence, this is a promising treatment of choice for the surgical management of scoliosis patients. © 2021 Author(s). |
connecting rod; corrective manipulation; extreme scoliosis; scoliosis correction |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
- |
177 |
20880 |
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511 |
Zakaria H., Valentine O., Mayza A. |
24465810100;57210969043;57211585788; |
Analysis of quantitative EEG (QEEG) parameters on the effect of transcranial direct current stimulation (TDCS) on post-stroke patients |
2021 |
AIP Conference Proceedings |
2344 |
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050001 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103483309&doi=10.1063%2f5.0047216&partnerID=40&md5=c64c2b06ed2088913d8d35589059c49a |
School of Electrical Engineering and Informatics, Bandung Institute of Technology (ITB), Jl. Ganesha No. 10, Bandung, 40132, Indonesia; Neurology Department and Cluster of Medical Technology IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Senen, Central Jakarta, 10430, Indonesia |
Zakaria, H., School of Electrical Engineering and Informatics, Bandung Institute of Technology (ITB), Jl. Ganesha No. 10, Bandung, 40132, Indonesia; Valentine, O., School of Electrical Engineering and Informatics, Bandung Institute of Technology (ITB), Jl. Ganesha No. 10, Bandung, 40132, Indonesia; Mayza, A., Neurology Department and Cluster of Medical Technology IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Senen, Central Jakarta, 10430, Indonesia |
Cerebrovascular accident (CVA) or stroke is a condition where the blood flow to the brain is impaired, which can be caused by a blockage (ischemic stroke) or rupture of blood vessels (hemorrhagic stroke), resulting in cell death in some brain areas. Stroke can cause significant impairment in motoric, cognitive, and coordination skills of limbs and muscles. One of the non-invasive stimuli that can be applied in post-stroke patient rehabilitation is Transcranial Direct Current Stimulation (TDCS), aiming to improve the frequency spectrum towards normal. This study aimed to find the Quantitative Electroenchepalograph (QEEG) parameters that characterize the improvement of post-stroke patients' brain signals after the administration of TDCS. QEEG parameters included absolute power, relative power, ratio power Delta Theta Alpha Beta (DTAB), Delta Alpha (DA), and the percentage of each frequency wave band in the brain. EEG signals were recorded for 5 minutes before and after TDCS administration from 23 subjects, consisted of 12 post-stroke patients and 11 healthy subjects as a control. The result showed that there were significant differences in QEEG parameters before and after TDCS administration to both post-stroke patients and healthy subjects. The alpha frequency was dominant for healthy subjects, with the average of 25.67% before stimulus then increased by 1.91% after the stimulus. For post-stroke patients, delta frequency before the stimulus was dominant, with an average percentage of 43.03% then decreased by 10.44% after the stimulus. These results show that with TDCS, there is a change in the EEG wave pattern in post-stroke patients, which followed the profile pattern of healthy subjects. © 2021 Author(s). |
Quantitative EEG (QEEG); Stroke; Transcranial Direct Current Stimulation (TDCS) |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
- |
177 |
20880 |
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512 |
Inayati R., Suhaeri M., Fahdia N., Remelia M., Antarianto R.D. |
57222623427;56183087500;57222625988;57209653885;57190862806; |
Optimization of hybrid PVA/hFDM scaffold preparation |
2021 |
AIP Conference Proceedings |
2344 |
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020012 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103481516&doi=10.1063%2f5.0049156&partnerID=40&md5=d049606831bf9a961d70f9a9c49ec7bf |
Master Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Rumah Sakit Universitas Indonesia, Kampus Universitas Indonesia, Depok, West Java, 16424, Indonesia; Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Doctoral Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Department of Basic Biomedicine, Faculty of Medicine, Universitas Kristen Indonesia, Jl Mayjen Sutoyo No 2, DKI Jakarta, 13630, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia |
Inayati, R., Master Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Suhaeri, M., Rumah Sakit Universitas Indonesia, Kampus Universitas Indonesia, Depok, West Java, 16424, Indonesia; Fahdia, N., Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Remelia, M., Doctoral Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia, Department of Basic Biomedicine, Faculty of Medicine, Universitas Kristen Indonesia, Jl Mayjen Sutoyo No 2, DKI Jakarta, 13630, Indonesia; Antarianto, R.D., Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia, Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia |
Osteogenic differentiation from Mesenchymal Stem Cell (MSC) to osteoblast has a clinical significance which is very important for treating bone injuries, in the form of femoral fractures with the most cases in Indonesia. Various studies have been conducted to find the best scaffold that can improve osteogenic differentiation, one of which is the development of a hybrid scaffold made from natural biomaterials in the form of the extracellular matrix, and from synthetic biomaterials. The discovery of the best scaffold is not only focused on the source of the scaffold but also requires optimization of the method in making the scaffold. Therefore, the aim of this study is to find out the optimum method for making hybrid scaffolds that support osteogenic differentiation from MSC. Materials and methods: human Fibroblast-derived Matrix (hFDM) as a hybrid scaffold material collected from decellularized fibroblasts cultures from post-cleft-surgery reconstruction palatal skin. Fibroblast cell cultures were divided into two groups of cultures, cultures without Platelet Rich Plasma (PRP), and cultures with the addition of PRP. For decellularization, we performed optimization at the preparation stage of the decellularization solution, and the time of culture for decellularization. In the preparation of the decellularization solution, we divided it into two groups, NH4OH as material from the decellularization solution was diluted with PBS before mixing with 0.25% Triton X-100, and NH4OH was diluted directly in 0.25% Triton X-100. In optimizing the culture time for decellularization, we divided it into three groups, decellularization on the day when cell growth reached 100% confluent, decellularization on the 3rd day after 100% confluent (H + 3) cells, and decellularization on the 4th day after 100% confluent (H + 4) cells. Next, the hFDM matrix is collected and added Polyvinyl Alcohol (PVA) solutions to form a hybrid PVA / hFDM scaffold in the form of a hydrogel. Observations on hybrid PVA / hFDM scaffolds were made using an inversion microscope. Results and discussion: Optimization of methods for culture techniques found that the addition of PRP to fibroblast culture medium increased the rate of fibroblast proliferation. For the decellularization technique, it is known that the preparation of the decellular solution by diluting NH4OH directly in 0.25% Triton X-100 to obtain a final concentration of 50mM NH4OH is known to be effectively used in decellularizing fibroblasts. The optimum culture time is also known that a thicker hFDM matrix can be obtained on day 4 after 100% confluent (H + 4) cells. Conclusion: Making a good hFDM hybrid PVA scaffold requires method optimization, ranging from fibroblast culture techniques and decellularization techniques. Proper optimization can produce a hybrid PVA / hFDM scaffold which is suitable for bone tissue engineering applications. © 2021 Author(s). |
decellularization; fibroblast culture; hybrid PVA/hFDM scaffold |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
- |
177 |
20880 |
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513 |
Rizal, Syaidah R., Aqsha Z.M., Josephin A., Pakpahan V.M. |
57222623832;55418885900;57222626455;57222619624;57222621602; |
Characterization, differentiation, and population doubling time of Wharton's jelly mesenchymal stem cells (WJ-MSCs) in passage 5 and 8 |
2021 |
AIP Conference Proceedings |
2344 |
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040002 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103479666&doi=10.1063%2f5.0047340&partnerID=40&md5=346f0fd284692390adaef1a8feae20b2 |
Biomedical Engineering Program, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Undergraduate Program in Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia |
Rizal, Biomedical Engineering Program, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Syaidah, R., Department of Histology, Faculty of Medicine, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Aqsha, Z.M., Undergraduate Program in Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Josephin, A., Undergraduate Program in Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Pakpahan, V.M., Undergraduate Program in Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia |
Wharton's jelly mesenchymal stem cells (WJ-MSCs) is proposed to be the best source of mesenchymal stem cells (MSCs). It has better self-renewal and differentiation capacity compare to adult stem cells such as bone marrow- derived stem cells (BM-MSCs). However, their characteristics in different passages do not yet well described. This research aims to isolate and characterize WJ-MSCs with regard to their proliferation capacity, immunophenotypes, and differentiation capacity. The WJ-MSCs were isolated by the explant method. The cultured WJ-MSCs at P5 and P8 were then characterized using flow cytometric analysis with regard to its surface marker, which are CD44, CD90, CD105, CD73, and negative lineages. The proliferation capacity of WJ-MSCs was analyzed with the population doubling time method and the characterized cells were differentiated into three different lineages. The result revealed that the isolated cells highly express MSCs surface marker with >98% for all surface markers and 0.00% for negative lineages. Isolated WJ-MSCs also exhibited a high proliferation capacity with a range of 1.06 to 1.59 days. Both passages revealed excellent differentiation capacity into chondrocytes, adipocytes, and osteocytes. © 2021 Author(s). |
characterization; differentiation; Mesenchymal stem cells; proliferation; Wharton's jelly |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
- |
177 |
20880 |
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514 |
Chang F.-Y., Wiratman W., Ugawa Y., Kobayashi S. |
57195621810;57191920526;7005460744;56508693300; |
Event-Related Potentials During Decision-Making in a Mixed-Strategy Game |
2021 |
Frontiers in Neuroscience |
15 |
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552750 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103554813&doi=10.3389%2ffnins.2021.552750&partnerID=40&md5=ef31052f38e98dcc5c24224d29264efc |
Department of Neurology, School of Medicine, Fukushima Medical University, Fukushima, Japan; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Human Neurophysiology, Fukushima Medical University, Fukushima, Japan; Department of Neurology, Takeda General Hospital, Fukushima, Japan; Department of Neurology, Teikyo University, Tokyo, Japan |
Chang, F.-Y., Department of Neurology, School of Medicine, Fukushima Medical University, Fukushima, Japan; Wiratman, W., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ugawa, Y., Department of Human Neurophysiology, Fukushima Medical University, Fukushima, Japan, Department of Neurology, Takeda General Hospital, Fukushima, Japan; Kobayashi, S., Department of Neurology, Teikyo University, Tokyo, Japan |
The decisions we make are sometimes influenced by interactions with other agents. Previous studies have suggested that the prefrontal cortex plays an important role in decision-making and that the dopamine system underlies processes of motivation, motor preparation, and reinforcement learning. However, the physiological mechanisms underlying how the prefrontal cortex and the dopaminergic system are involved in decision-making remain largely unclear. The present study aimed to determine how decision strategies influence event-related potentials (ERPs). We also tested the effect of levodopa, a dopamine precursor, on decision-making and ERPs in a randomized double-blind placebo-controlled investigation. The subjects performed a matching-pennies task against an opposing virtual computer player by choosing between right and left targets while their ERPs were recorded. According to the rules of the matching-pennies task, the subject won the trial when they chose the same side as the opponent, and lost otherwise. We set three different task rules: (1) with the alternation (ALT) rule, the computer opponent made alternating choices of right and left in sequential trials; (2) with the random (RAND) rule, the opponent randomly chose between right and left; and (3) with the GAME rule, the opponent analyzed the subject’s past choices to predict the subject’s next choice, and then chose the opposite side. A sustained medial ERP became more negative toward the time of the subject’s target choice. A biphasic potential appeared when the opponent’s choice was revealed after the subject’s response. The ERPs around the subject’s choice were greater in RAND and GAME than in ALT, and the negative peak was enhanced by levodopa. In addition to these medial ERPs, we observed lateral frontal ERPs tuned to the choice direction. The signals emerged around the choice period selectively in RAND and GAME when levodopa was administered. These results suggest that decision processes are modulated by the dopamine system when a complex and strategic decision is required, which may reflect decision updating with dopaminergic prediction error signals. © Copyright © 2021 Chang, Wiratman, Ugawa and Kobayashi. |
executive function; feedback; game theory; high-density EEG; levodopa; Parkinson’s disease; prefrontal cortex; readiness potential |
dopamine; levodopa; Article; behavior; clinical article; contingent negative variation; controlled study; diffusion weighted imaging; dopaminergic system; electroencephalography; electrophysiology; entropy; event related potential; executive function; female; gray matter; human experiment; local field potential; male; middle aged; normal human; Parkinson disease; prefrontal cortex; randomized controlled trial; social behavior; task performance |
Frontiers Media S.A. |
16624548 |
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Article |
Q2 |
1499 |
2279 |
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515 |
Scheibein F., Stowe M.J., Arya S., Morgan N., Shirasaka T., Grandinetti P., Saad N.A., Ghosh A., Vadivel R., Ratta-apha W., Pant S.B., Ransing R., Ramalho R., Bruschi A., Maiti T., HA A.Y., Delic M., Jain S., Peyron E., Siste K., Onoria J., Boujraf S., Dannatt L., Schellekens A., Calvey T. |
57212313904;57217388837;35463222300;57201914207;7005625709;55487378900;57219875515;36833820900;57219874702;35604346900;36114863900;57190296865;56789745200;35298539700;57193679395;57222620752;24476120800;57207211289;57205355338;55644113100;57219876130;57220277366;57200537348;14323807600;55634512900; |
Responding to COVID-19: Emerging Practices in Addiction Medicine in 17 Countries |
2021 |
Frontiers in Psychiatry |
12 |
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634309 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103517973&doi=10.3389%2ffpsyt.2021.634309&partnerID=40&md5=5075a0b04e57dd3c3530b131f94ef9a7 |
School of Health Sciences, Waterford Institute of Technology, Waterford, Ireland; Department of Family Medicine, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa; State Drug Dependence Treatment Centre, Institute of Mental Health, Pt Bhagwat Dayal Sharma, University of Health Sciences, Rohtak, India; University of the Witwatersrand, Johannesburg, South Africa; Department of Psychiatry, Teine Keijinkai Medical Center, Sapporo, Japan; Addiction Services (SerD), Department of Territorial Services, ASL Teramo, Teramo, Italy; Department of Psychiatry, Ain Shams University, Cairo, Egypt; Drug Deaddiction and Treatment Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Waikato District Health Board, Waikato, New Zealand; Faculty of Medicine Siriraj Hospital, Mahidol University, Salaya, Thailand; Department of Psychiatry and Mental Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal; Department of Psychiatry, BKL Walawalkar Rural Medical College, Ratnagiri, India; Department of Social and Community Health, School of Population Health, The University of Auckland, Auckland, New Zealand; Department of Mental Health, ASL Viterbo, Viterbo, Italy; Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, India; Department of Psychological Medicine, University Malaya Centre of Addiction Sciences (UMCAS), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Center for Treatment of Drug Addiction, University Psychiatric Clinic Ljubljana, Ljubljana, Slovenia; Department of Psychiatry, Heritage Institute of Medical Sciences (HIMS), Varanasi, India; AddiPsy, Lyon, France; Department of Psychiatry, Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital, Jakarta, Indonesia; Department of Psychiatry, College of Health Sciences, Makerere University, Kampala, Uganda; Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University of Fez, Fes, Morocco; Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Radboud University Medical Centre, Nijmegen, Netherlands; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa |
Scheibein, F., School of Health Sciences, Waterford Institute of Technology, Waterford, Ireland; Stowe, M.J., Department of Family Medicine, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa; Arya, S., State Drug Dependence Treatment Centre, Institute of Mental Health, Pt Bhagwat Dayal Sharma, University of Health Sciences, Rohtak, India; Morgan, N., University of the Witwatersrand, Johannesburg, South Africa; Shirasaka, T., Department of Psychiatry, Teine Keijinkai Medical Center, Sapporo, Japan; Grandinetti, P., Addiction Services (SerD), Department of Territorial Services, ASL Teramo, Teramo, Italy; Saad, N.A., Department of Psychiatry, Ain Shams University, Cairo, Egypt; Ghosh, A., Drug Deaddiction and Treatment Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Vadivel, R., Waikato District Health Board, Waikato, New Zealand; Ratta-apha, W., Faculty of Medicine Siriraj Hospital, Mahidol University, Salaya, Thailand; Pant, S.B., Department of Psychiatry and Mental Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal; Ransing, R., Department of Psychiatry, BKL Walawalkar Rural Medical College, Ratnagiri, India; Ramalho, R., Department of Social and Community Health, School of Population Health, The University of Auckland, Auckland, New Zealand; Bruschi, A., Department of Mental Health, ASL Viterbo, Viterbo, Italy; Maiti, T., Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, India; HA, A.Y., Department of Psychological Medicine, University Malaya Centre of Addiction Sciences (UMCAS), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Delic, M., Center for Treatment of Drug Addiction, University Psychiatric Clinic Ljubljana, Ljubljana, Slovenia; Jain, S., Department of Psychiatry, Heritage Institute of Medical Sciences (HIMS), Varanasi, India; Peyron, E., AddiPsy, Lyon, France; Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital, Jakarta, Indonesia; Onoria, J., Department of Psychiatry, College of Health Sciences, Makerere University, Kampala, Uganda; Boujraf, S., Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University of Fez, Fes, Morocco; Dannatt, L., Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Schellekens, A., Radboud University Medical Centre, Nijmegen, Netherlands; Calvey, T., Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa |
[No abstract available] |
addiction medicine; behaviourial addictions; best practice; COVID-19; drug policy; guidelines; substance use |
addiction; addiction medicine; Article; coronavirus disease 2019; health care policy; human; international cooperation; practice guideline; substance use |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
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516 |
Rosa B.A., Snowden C., Martin J., Fischer K., Kupritz J., Beshah E., Supali T., Gankpala L., Fischer P.U., Urban J.F., Jr., Mitreva M. |
15519661800;57215576664;56537265100;55807725800;57211116674;6506448106;6602742029;55801653400;23567680200;7202366458;6507392205; |
Whipworm-Associated Intestinal Microbiome Members Consistent Across Both Human and Mouse Hosts |
2021 |
Frontiers in Cellular and Infection Microbiology |
11 |
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637570 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103118895&doi=10.3389%2ffcimb.2021.637570&partnerID=40&md5=27cf0d3a842448c6a8e6d26ccd8dd43e |
Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; U.S. Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Animal Parasitic Diseases Laboratory, Beltsville, MD, United States; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Public Health and Medical Research, National Public Health Institute of Liberia, Charlesville, Liberia; Department of Genetics, Washington University School of Medicine, St. Louis, MO, United States; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, United States |
Rosa, B.A., Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Snowden, C., Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Martin, J., Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Fischer, K., Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Kupritz, J., Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Beshah, E., U.S. Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Animal Parasitic Diseases Laboratory, Beltsville, MD, United States; Supali, T., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Gankpala, L., Public Health and Medical Research, National Public Health Institute of Liberia, Charlesville, Liberia; Fischer, P.U., Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Urban, J.F., Jr., U.S. Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Animal Parasitic Diseases Laboratory, Beltsville, MD, United States; Mitreva, M., Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States, Department of Genetics, Washington University School of Medicine, St. Louis, MO, United States, McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, United States |
The human whipworm Trichuris trichiura infects 289 million people worldwide, resulting in substantial morbidity. Whipworm infections are difficult to treat due to low cure rates and high reinfection rates. Interactions between whipworm and its host’s intestinal microbiome present a potential novel target for infection control or prevention but are very complicated and are identified using inconsistent methodology and sample types across the literature, limiting their potential usefulness. Here, we used a combined 16S rRNA gene OTU analysis approach (QIIME2) for samples from humans and mice infected with whipworm (T. trichiura and T. muris, respectively) to identify for the first time, bacterial taxa that were consistently associated with whipworm infection spanning host species and infection status using four independent comparisons (baseline infected vs uninfected and before vs after deworming for both humans and mice). Using these four comparisons, we identified significant positive associations for seven taxa including Escherichia, which has been identified to induce whipworm egg hatching, and Bacteroides, which has previously been identified as a major component of the whipworm internal microbiome. We additionally identified significant negative associations for five taxa including four members of the order Clostridiales, two from the family Lachnospiraceae, including Blautia which was previously identified as positively associated with whipworm in independent human and mouse studies. Using this approach, bacterial taxa of interest for future association and mechanistic studies were identified, and several were validated by RT-qPCR. We demonstrate the applicability of a mouse animal model for comparison to human whipworm infections with respect to whipworm-induced intestinal microbiome disruption and subsequent restoration following deworming. Overall, the novel cross-species analysis approach utilized here provides a valuable research tool for studies of the interaction between whipworm infection and the host intestinal microbiome. © Copyright © 2021 Rosa, Snowden, Martin, Fischer, Kupritz, Beshah, Supali, Gankpala, Fischer, Urban and Mitreva. |
animal model; helminth; intestinal microbiota; microbiome; whipworm |
albendazole; ivermectin; mebendazole; RNA 16S; RNA 16S; adult; ancylostomiasis; Article; Bacteroides; Blautia; child; Clostridiales; DNA extraction; Escherichia; feces analysis; female; gene sequence; human; infection control; intestine flora; Lachnospiraceae; male; molecular genetics; morbidity; nonhuman; polymerase chain reaction; real time polymerase chain reaction; reverse transcription polymerase chain reaction; taxonomy; trichuriasis; Trichuris muris; Trichuris trichiura; animal; genetics; microflora; mouse; trichuriasis; Trichuris; Animals; Gastrointestinal Microbiome; Humans; Mice; Microbiota; RNA, Ribosomal, 16S; Trichuriasis; Trichuris |
Frontiers Media S.A. |
22352988 |
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33777847 |
Article |
Q1 |
1812 |
1607 |
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517 |
Anindyajati G., Wiguna T., Murtani B.J., Christian H., Wigantara N.A., Putra A.A., Hanafi E., Minayati K., Ismail R.I., Kaligis F., Savitri A.I., Uiterwaal C.S.P.M., Diatri H. |
57194606169;24367785700;57216652176;57209266195;57218679014;57220161382;56737010600;57218681686;55996895500;36604651700;56401804100;7006033434;36113389500; |
Anxiety and Its Associated Factors During the Initial Phase of the COVID-19 Pandemic in Indonesia |
2021 |
Frontiers in Psychiatry |
12 |
|
634585 |
|
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|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102995915&doi=10.3389%2ffpsyt.2021.634585&partnerID=40&md5=b28d0b2bafd0f4413cc6d469ba102a50 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; The Center for Clinical Epidemiology and Evidence-Based Medicine Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands |
Anindyajati, G., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wiguna, T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Christian, H., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wigantara, N.A., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Putra, A.A., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hanafi, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Minayati, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ismail, R.I., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kaligis, F., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Savitri, A.I., The Center for Clinical Epidemiology and Evidence-Based Medicine Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Uiterwaal, C.S.P.M., Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Diatri, H., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus which has not been identified previously in humans. The disease leads to respiratory problems, systemic disorders, and death. To stop the virus transmission, physical distancing was strongly implemented, including working and school from home (WFH & SFH). The limitation altered daily routines and needs advanced to adapt. Many have felt uncomfortable and this could have triggered anxiety symptoms. This study aimed to evaluate the proportion of significant anxiety symptoms and its association with COVID-19-related situations in an Indonesian context during the initial months of the pandemic. Methods: An online community survey was distributed through social media and communication platforms, mainly WhatsApp, targeting people >18 years old in Indonesia. Anxiety symptoms were assessed using Generalized Anxiety Disorder-7 (Indonesian Version). Demographical data and information on social situation related to the COVID-19 pandemic were collected. The proportion of clinically significant anxiety symptoms was calculated and the association with demographic and social factors was assessed using chi square test (χ2) and logistic regression for multivariate analysis. Results: Out of 1215 subjects that completed the survey, 20.2% (n = 245) exhibited significant anxiety symptoms. Several factors, such as age (AOR = 0.933 CI 95% = 0.907–0.96), sex (AOR = 1.612 CI 95% = 1.097–2.369), medical workers (AOR = 0.209 CI 95% = 0.061–0.721), suspected case of COVID-19 (AOR = 1.786 CI 95% = 1.001–3.186), satisfaction level of family support (AOR = 3.052 CI 95% = 1.883–4.946), and satisfaction level of co-workers (AOR = 2.523 CI 95% = 1.395–4.562), were associated with anxiety. Conclusion: One out of five Indonesian people could have suffered from anxiety during the COVID-19 pandemic. The riskiest group being young females, people who had suspected cases of COVID-19, and those with less satisfying social support. Nevertheless, health workers were found to have a lesser risk of developing anxiety. Accessible information and healthcare, social connection, supportive environment, and mental health surveillance are important to prevent bigger psychiatric problems post-pandemic. © Copyright © 2021 Anindyajati, Wiguna, Murtani, Christian, Wigantara, Putra, Hanafi, Minayati, Ismail, Kaligis, Savitri, Uiterwaal and Diatri. |
anxiety; COVID-19 pandemic; Indonesian; mental health surveillance; psychosocial support |
adult; anxiety disorder; Article; controlled study; coronavirus disease 2019; disease association; female; generalized anxiety disorder; high risk population; human; Indonesia; major clinical study; male; mental health; pandemic; patient satisfaction; psychosocial care; risk assessment; risk factor; social support; support group |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
|
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519 |
Dannatt L., Ransing R., Calvey T., Scheibein F., Saad N.A., Shirasaka T., Ramalho R., Pant S., Vadivel R., Siste K., Stowe M.J., Kalita K.N., Boujraf S., Testa R., Arya S., Morgan N., Grandinetti P. |
57200537348;57190296865;55634512900;57212313904;57219875515;7005625709;56789745200;36114863900;57219874702;55644113100;57217388837;54387032200;57220277366;57222475193;35463222300;57201914207;55487378900; |
The Impact of Stigma on Treatment Services for People With Substance Use Disorders During the COVID-19 Pandemic—Perspectives of NECPAM Members |
2021 |
Frontiers in Psychiatry |
12 |
|
634515 |
|
|
|
5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102821643&doi=10.3389%2ffpsyt.2021.634515&partnerID=40&md5=f473eb1aa0aba07997e39ee4f82c800a |
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; Department of Psychiatry, Bhaktshreshtha Kamalakarpant Laxman (BKL) Walalwalkar Rural Medical College, Pune, India; Faculty of Health Sciences, School of Anatomical Sciences, University of the Witwatersrand, Johannesburg, South Africa; School of Health Science, Waterford Institute of Technology, Waterford, Ireland; State Drug Dependence Treatment Centre, Ain Shams University, Cairo, Egypt; Department of Psychiatry, Teine Keijinkai Medical Center, Sapporo, Japan; Department of Social and Community Health, School of Population Health, University of Auckland, Auckland, New Zealand; Department of Psychiatry, Institute of Medicine, Tribhuvan University, Kirtipur, Nepal; Department of Psychiatry, Medical Faculty, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Family Medicine, Faculty of Health Sciences, School of Medicine, University of Pretoria, Pretoria, South Africa; Department of Psychiatry, Lokopriya Gopinath Bordoloi Regional Institute of Mental Health (LGBRIMH), Tezpur, India; Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco; Department of Mental Health, Azienda Sanitaria Locale (ASL), 1 Avezzano-L'Aquila-Sulmona, L'Aquila, Italy; State Drug Dependence Treatment Centre, Institute of Mental Health, Pt. Bhagwat Dayal Sharma (BDS), University of Health Sciences, Rohtak, India; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Mental Helth, Azienda Sanitaria Locale (ASL) Teramo, Teramo, Italy |
Dannatt, L., Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; Ransing, R., Department of Psychiatry, Bhaktshreshtha Kamalakarpant Laxman (BKL) Walalwalkar Rural Medical College, Pune, India; Calvey, T., Faculty of Health Sciences, School of Anatomical Sciences, University of the Witwatersrand, Johannesburg, South Africa; Scheibein, F., School of Health Science, Waterford Institute of Technology, Waterford, Ireland; Saad, N.A., State Drug Dependence Treatment Centre, Ain Shams University, Cairo, Egypt; Shirasaka, T., Department of Psychiatry, Teine Keijinkai Medical Center, Sapporo, Japan; Ramalho, R., Department of Social and Community Health, School of Population Health, University of Auckland, Auckland, New Zealand; Pant, S., Department of Psychiatry, Institute of Medicine, Tribhuvan University, Kirtipur, Nepal; Vadivel, R.; Siste, K., Department of Psychiatry, Medical Faculty, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Stowe, M.J., Department of Family Medicine, Faculty of Health Sciences, School of Medicine, University of Pretoria, Pretoria, South Africa; Kalita, K.N., Department of Psychiatry, Lokopriya Gopinath Bordoloi Regional Institute of Mental Health (LGBRIMH), Tezpur, India; Boujraf, S., Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco; Testa, R., Department of Mental Health, Azienda Sanitaria Locale (ASL), 1 Avezzano-L'Aquila-Sulmona, L'Aquila, Italy; Arya, S., State Drug Dependence Treatment Centre, Institute of Mental Health, Pt. Bhagwat Dayal Sharma (BDS), University of Health Sciences, Rohtak, India; Morgan, N., Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Grandinetti, P., Department of Mental Helth, Azienda Sanitaria Locale (ASL) Teramo, Teramo, Italy |
[No abstract available] |
access to treatment; COVID-19; mental health; pandemic; stigma; substance use disorder |
benzodiazepine; naloxone; opiate agonist; Article; behavioral addiction; coronavirus disease 2019; drug dependence; drug dependence treatment; harm reduction; health care access; health care planning; health care policy; high risk population; homelessness; human; mental health care; pandemic; practice guideline; social discrimination; social distancing; stigma; vulnerable population |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
|
|
526 |
Pudjiadi A.H., Antonjaya U., Myint K.S., Alatas F.S. |
18435202300;36016109600;7003758970;57217150164; |
Echovirus-7 infection in children with unusual severe manifestation: A case report |
2021 |
Infection and Chemotherapy |
53 |
|
|
141 |
145 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104262436&doi=10.3947%2fIC.2020.0081&partnerID=40&md5=80e71bfc568af5c4cf2736e907d992fe |
Department of Child-Health, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Eijkman Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Emerging Virus Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Pudjiadi, A.H., Department of Child-Health, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Antonjaya, U., Eijkman Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Myint, K.S., Emerging Virus Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Alatas, F.S., Department of Child-Health, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
We report a rare laboratory-confirmed, clinical case of Echovirus-7 infection in an immunocompetent child with central nervous system and systemic manifestation. Echovirus infection is usually mild, however in this case we identified echovirus-7 infection with 91% homology with the Echovirus-7 strain previously isolated in neighbouring country with severe manifestation. Copyright © 2021 by The Korean Society of Infectious Diseases, |
Echovirus-7; Encephalitis; Enterovirus; QRT-PCR; Sepsis |
cephalosporin; phenobarbital; procalcitonin; thromboplastin; valproic acid; Article; blood gas analysis; breathing rate; case report; cerebrospinal fluid; childhood disease; clinical article; differential diagnosis; digestive system injury; disease severity; disseminated intravascular clotting; echovirus 7 infection; Echovirus infection; ego development; emergency ward; family history; fever; Glasgow coma scale; heart rate; hemoglobin blood level; hospital admission; hospitalization; human; hypokalemia; infant; laboratory test; leukopenia; lung auscultation; male; nose smear; nucleotide sequence; physical examination; platelet count; prothrombin time; Pseudomonas aeruginosa; real time reverse transcription polymerase chain reaction; rectal swab; rectal temperature; seizure; sepsis; sputum |
Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, Korean Society for AIDS |
20932340 |
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Article |
Q2 |
724 |
6845 |
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