No records
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841 |
Wijaya D.A., Louisa M., Wibowo H., Taslim A., Permata T.B.M., Handoko, Nuryadi E., Kodrat H., Gondhowiardjo S.A. |
57222657856;41461551400;57217690943;57222661883;57197808751;57209984822;57197806814;57210639849;6508327402; |
The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agents: Proposed mechanisms based on a systematic review |
2021 |
Journal of HerbMed Pharmacology |
10 |
2 |
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166 |
178 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103633859&doi=10.34172%2fjhp.2021.18&partnerID=40&md5=810428f36d6d7326990b348f1d1a958a |
Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Laboratorium Terpadu, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia |
Wijaya, D.A., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Wibowo, H., Laboratorium Terpadu, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Taslim, A., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Permata, T.B.M., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Handoko, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Kodrat, H., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Gondhowiardjo, S.A., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia |
Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds such as annonaceous acetogenins, annomuricin, annonacin, or curcumin; and further correlated them with the potential of the mechanism to increase or to reduce cancer cells radio-sensitivity based on literature investigation. We see that AM has a promising future potential as a radio-sensitizer agent. © 2021 Nickan Research Institute. All rights reserved. |
Annona muricata; Bioactive compounds; Plant extract; Radio-sensitivity; Radiotherapy |
acetogenin; Annona muricata extract; annonacin; apoptosome; caspase 9; curcumin; cyclin D1; cyclin D2; death domain receptor signaling adaptor protein; Fas ligand; glucose transporter 4; glycogen synthase kinase; hypoxia inducible factor 1alpha; immunoglobulin light chain; interleukin 13; lactate dehydrogenase; mammalian target of rapamycin; mitogen activated protein kinase; mitogen activated protein kinase 1; mitogen activated protein kinase 3; phosphatidylserine; procaspase 3; protein Bax; protein bcl 2; protein mcl 1; protein p105; protein p50; protein p53; radiosensitizing agent; reactive oxygen metabolite; STAT3 protein; stress activated protein kinase; transcription factor RelA; transcription factor RelB; tumor necrosis factor; Annona muricata; apoptosis; B cell lymphoma; cell aging; |
Nickan Research Institute |
23455004 |
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Review |
Q3 |
341 |
13610 |
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No records
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523 |
Octaviana F., Bestari A., Loho A., Indrawati L., Wiratman W., Kurniawan M., Sugiarto A., Budikayanti A. |
26029958700;57223262097;57223264641;57205117182;57191920526;57196001182;57189612291;57194713932; |
Nonconvulsive Status Epilepticus in Metabolic Encephalopathy in Indonesia Referral Hospital |
2021 |
Neurology India |
69 |
2 |
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354 |
359 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105413010&doi=10.4103%2f0028-3886.314533&partnerID=40&md5=41f369c55e5b08a8b0bd905ac5493afd |
Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Octaviana, F., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Bestari, A., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Loho, A., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Indrawati, L., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wiratman, W., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Kurniawan, M., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sugiarto, A., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Budikayanti, A., Department of Neurology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Background: Nonconvulsive status epilepticus (NCSE) is often underdiagnosed in patients with metabolic encephalopathy (ME). The diagnosis of ME should be made specifically to recognize the underlying etiology. Delay in seizure identification and making a diagnosis of NCSE contributed to the poor outcome. Objective: This study aimed to find the incidence and outcome of NCSE in patients with ME. Methods and Material: This was an observational prospective cross-sectional study in patients with ME in emergency and critical care units in Cipto Mangunkusumo General Hospital. The diagnosis of NCSE was based on EEG using Salzburg Criteria for Nonconvulsive Status Epilepticus (SCNC). The outcome was assessed within 30 days after the NCSE diagnosis has been made. Results: A total of 50 patients with ME were involved in this study. NCSE was confirmed in 32 subjects (64%). The most common etiology of ME was sepsis (58%). The mortality rate in the NCSE and non-NCSE group was 40.6% vs 44.4%. Multiple aetiologies were risk factors to poor outcome in the NCSE group. Conclusions: The incidence of NCSE among patients with ME at our hospital was high. Despite the anti-epileptic treatment of the NCSE group, the underlying cause of ME is still the main factor that affected the outcome. Therefore, aggressive treatment of anti-epileptic drug (AED) should be very carefully considered knowing the possible side-effect that might worsen the outcome of patients with ME. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Metabolic encephalopathy; mortality; non-convulsive status epilepticus |
diazepam; levetiracetam; midazolam; phenobarbital; phenytoin; propofol; valproic acid; adult; Article; clinical article; cross-sectional study; electroencephalography; epileptic state; female; human; incidence; Indonesia; male; metabolic encephalopathy; mortality rate; nonconvulsive status epilepticus; observational study; prognosis; risk factor; sepsis; epileptic state; hospital; metabolic encephalopathy; patient referral; prospective study; Brain Diseases, Metabolic; Cross-Sectional Studies; Electroencephalography; Hospitals; Humans; Indonesia; Prospective Studies; Referral and Consultation; Status Epilepticus |
Wolters Kluwer Medknow Publications |
00283886 |
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33904451 |
Article |
Q3 |
339 |
13675 |
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No records
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878 |
Sitohang I.B.S., Rheza A.M., Sirait S.P., Fitri E.M., Suseno L.S. |
56734569200;57221927642;56426927400;57221929310;57202804092; |
Acne Vulgaris Mimicking Cutaneous Lupus Erythematosus in an Adolescent: Report of a Rare Case |
2021 |
Case Reports in Dermatology |
13 |
1 |
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69 |
74 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100667271&doi=10.1159%2f000511530&partnerID=40&md5=e670f0805c017b254cadf2cd24514e56 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jalan Salemba No. 6, Jakarta, 10430, Indonesia |
Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jalan Salemba No. 6, Jakarta, 10430, Indonesia; Rheza, A.M., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jalan Salemba No. 6, Jakarta, 10430, Indonesia; Sirait, S.P., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jalan Salemba No. 6, Jakarta, 10430, Indonesia; Fitri, E.M., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jalan Salemba No. 6, Jakarta, 10430, Indonesia; Suseno, L.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jalan Salemba No. 6, Jakarta, 10430, Indonesia |
Acne vulgaris is a chronic and self-limiting disorder of the pilosebaceous unit which is primarily seen in adolescents. Acne vulgaris presents as polymorphic lesions, consisting of comedones, papules, pustules, cysts, nodules, scarring, and dyspigmentation. Acneiform presentation of cutaneous lupus erythematosus (CLE) is extremely rare. The presentation of CLE is notoriously diverse and often mimics a broad range of unrelated skin disorders. We present a case by referring to American College of Rheumatology (ACR) criteria for systemic lupus erythematosus (SLE); our patient's conditions did not meet any of the clinical criteria of the Systemic Lupus International Collaborating Clinics (SLICC) for SLE. Subsequent to thorough history-taking, physical examination, and laboratory evaluations, the diagnosis of acne vulgaris was established, and a diagnosis of CLE was excluded. As acneiform presentation of CLE is rare, we here present a case which resembled both acne vulgaris and CLE. We describe our experience in establishing the diagnosis of severe acne vulgaris accompanied by scars in a 12-year-old boy with a malar rash and scars on his frontal and malar area who had initially been misdiagnosed as having CLE. This unusual case highlights the broad spectrum of adolescent acne and the importance of clinical identification of the disease so that unnecessary workups might be avoided. © 2021 |
Adolescent; Cutaneous lupus erythematosus; Severe acne vulgaris |
2 hydroxyacid; antinuclear antibody; benzoyl peroxide; clindamycin; complement component C3; glycolic acid; retinoic acid; triamcinolone acetonide; acne; acne vulgaris; adolescent; Article; brain spongiosis; case report; child; clinical article; comedo; diagnostic error; epiluminescence microscopy; erythema; follow up; histopathology; human; human tissue; hyperpigmentation; hypertrophic scar; immunofluorescence; male; papule; physical examination; pustule; rash; scar; school child; skin biopsy; skin defect; skin lupus erythematosus; systemic lupus erythematosus; urinalysis |
S. Karger AG |
16626567 |
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Article |
Q3 |
338 |
13690 |
|
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879 |
Sitohang I.B.S., Parrol F., Fitri E.M., Nora R.L.D. |
56734569200;57221938934;57221929310;57216253806; |
Papulopustular and Ocular Rosacea with an Alleged Coincidence of Cutaneous Lupus Erythematosus: A Case Report |
2021 |
Case Reports in Dermatology |
13 |
1 |
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62 |
68 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100608017&doi=10.1159%2f000511495&partnerID=40&md5=d9521d968dd743848325d6f5df3a4bf9 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jalan Salemba No. 6, Jakarta, 10430, Indonesia; Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jalan Salemba No. 6, Jakarta, 10430, Indonesia; Parrol, F., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jalan Salemba No. 6, Jakarta, 10430, Indonesia; Fitri, E.M., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jalan Salemba No. 6, Jakarta, 10430, Indonesia; Nora, R.L.D., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Rosacea is a chronic inflammatory skin disease characterized by central facial erythema with or without ocular involvement. It is often difficult to distinguish rosacea from other malar rashes, one of which is acute cutaneous lupus erythematosus (CLE), particularly when there is an increase in antinuclear antibody (ANA) level. We report the case of a 16-year old woman with facial erythematous plaque accompanied by papules and pustules, reddened eyes, and swollen eyelids since the last one year. Dermoscopic examination revealed telangiectasia, and skin scraping examination with 20% potassium hydroxide identified the presence of Demodex folliculorum. Further ocular examination also revealed blepharitis, dysfunction of Meibomian gland, cicatrix, and corneal neovascularization. The ANA titer was positive (1:320), while the anti-dsDNA was negative. The patient was treated according to standard treatment for rosacea. The patient showed a satisfactory response following 2 weeks of therapy. Signs of recurring red patches with papules, pustules, telangiectasia, and identification of D. folliculorum on skin scraping examination led to the diagnosis of papulopustular rosacea. A positive ANA test may also be present in other diseases, e.g. acute CLE. Therefore, the diagnosis of rosacea remains a challenge. Thorough observation and examination must be done in order to yield an accurate diagnosis of rosacea. © 2021 |
Case report; Cutaneous lupus erythematosus; Ocular rosacea; Papulopustular rosacea |
adapalene; antinuclear antibody; doxycycline; hydroxychloroquine; metronidazole; nitric oxide; potassium hydroxide; rheumatoid factor; abdominal pain; adolescent; anemia; arthralgia; Article; blepharitis; case report; clinical article; conjunctival hyperemia; conjunctivitis; cornea neovascularization; Demodex; Demodex folliculorum; dermatitis; dyspnea; eye examination; face erythema; female; food intake; hair loss; headache; histopathology; human; meibomian gland; oxidative stress; papule; periorbital edema; psoriasis; psoriatic arthritis; pustule; rosacea; scar; skin biopsy; skin defect; sun exposure; systemic lupus erythematosus; telangiectasia |
S. Karger AG |
16626567 |
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Article |
Q3 |
338 |
13690 |
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No records
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865 |
Silitonga P., Dewi B.E., Bustamam A., Al-Ash H.S. |
57219406661;24076058600;36815737800;57205062769; |
Evaluation of Dengue Model Performances Developed Using Artificial Neural Network and Random Forest Classifiers |
2021 |
Procedia Computer Science |
179 |
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135 |
143 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101780236&doi=10.1016%2fj.procs.2020.12.018&partnerID=40&md5=bf5f6b6b59db9e4a155ff56ac22ceeaf |
Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.5, Jakarta Pusat, Jakarta, 10430, Indonesia; Department of Computer Science, Faculty of Computer Science, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia |
Silitonga, P., Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Dewi, B.E., Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.5, Jakarta Pusat, Jakarta, 10430, Indonesia; Bustamam, A., Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Al-Ash, H.S., Department of Computer Science, Faculty of Computer Science, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia |
Dengue is one of the endemic diseases in Indonesia. Dengue is being suffered by many people, regardless of their gender and age. Therefore, research about dengue based on dengue patients' data was conducted. There was a lot of information written in that data regarding the corresponding patients and the dengue they had suffered, such as gender, age, how long the patients were hospitalized, the symptoms they experienced, and laboratory characteristics results. Diagnosis of each of the corresponding patients based on their symptoms and laboratory characteristics results were also written in that data. The diagnoses were classified into three different clinical degrees according to the severity level, which is DF as the mild level, DHF grade 1 as the intermediate level, and DHF grade 2 as the severe level. In this research, data of the patients on the third day of being hospitalized was analyzed, because, on the third day, dengue is entering a critical phase. The objectives of this research were: to evaluate the performance of the models that were used to predict the correct class within the given dataset developed using Artificial Neural Network (ANN) classifier and Random Forest (RF) classifier separately, and to find a classifier that yielded the best performance. The results obtained from this research will be used in the development of a Machine Learning model that can predict the clinical degree of dengue in the critical phase, if the laboratory characteristics results are known, using a classifier that yielded the best performance. © 2021 Elsevier B.V.. All rights reserved. |
Artificial Neural Network; Dengue; Random Forest |
Classification (of information); Clinical research; Decision trees; Diagnosis; Intelligent computing; Random forests; Turing machines; Indonesia; Intermediate level; Machine learning models; Model performance; Random forest classifier; Neural networks |
Elsevier B.V. |
18770509 |
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Conference Paper |
- |
334 |
13810 |
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No records
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456 |
Bahtiar A., Setyowati H., Mahanani R., Wati A., Arsianti A., Fadilah F. |
35365874400;57223255498;57223266884;57223271215;36124567000;56966708600; |
Rhaponticin contained Rheum officinale root extract improved Postmenopause symptom of Ovariectomized Rat |
2021 |
Journal of Advanced Pharmaceutical Technology and Research |
12 |
2 |
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175 |
179 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105384592&doi=10.4103%2fjaptr.JAPTR_324_20&partnerID=40&md5=1f1fbda205bf337ab7c1628298d5d1ba |
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Kampus UI Jl, Salemba Raya, Jakarta, Indonesia |
Bahtiar, A., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Setyowati, H., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Mahanani, R., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Wati, A., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Arsianti, A., Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Kampus UI Jl, Salemba Raya, Jakarta, Indonesia; Fadilah, F., Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Kampus UI Jl, Salemba Raya, Jakarta, Indonesia |
Postmenopausal women have decreased levels of the hormone estrogen. Reduced estrogen levels will often involve many symptoms that reduced quality of life. This research aims to analyze the effects of Rheum officinale root extract on postmenopausal model rats. To this end, thirty rats underwent ovariectomy (OVX) surgery and six rats were operated without having their ovaries removed. The OVX was confirmed by body weight-uterus weight ratio and a vaginal swab. Six groups of the rats were performed: SHAM group and negative control groups are given vehicle; the positive control was assigned tamoxifen; and the extract has been given three doses 7, 35, and 175 mg/200 g BW, respectively, for 30 days. The calcium content of bone ash was measured using atomic absorption spectrophotometer. Blood pressure was evaluated using CODA®, and the metabolites in the blood were assessed using gas chromatography-mass spectrometry (MS) and high-performance liquid chromatography. As a result, using ultra-performance liquid chromatography (UPLC)-MS, we found that the extract's major component was rhaponticin and its metabolites. The bone calcium levels increased with increasing doses of the extract. In the OVX group, the bone calcium content was decreased significantly 51.56% ± 8.9% g compared with the SHAM group 62.97% ±5.6% g, and the administration of Rheum extract could restore the calcium content of the bone to become 69.27% ± 3.8% g. From the above data, we concluded that Rheum root extracts contain astrigin, rhaponticin, rhapontigenin, and desoxyrhaponticin. Rheum root extract could improve calcium content and lipid profiles of OVX rats by stimulation osteoblastogenesis. Rheum root extracts could control the blood pressure of OVX rats by reducing lipid profiles. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Calcium; hypertension; Kalembak; lipid profiles; osteoporosis; postmenopausal; rhaponticin; Rheum officinale |
antihypertensive agent; astringin; calcium; cholesterol; desoxyrhaponticin; high density lipoprotein; low density lipoprotein; rhapontigenin; rhapontin; Rheum officinale extract; tamoxifen; triacylglycerol; unclassified drug; analytical parameters; animal experiment; animal model; animal tissue; antihypertensive activity; Article; atomic absorption spectrometry; blood pressure measurement; body weight; body weight gain; body weight uterus weight ratio; bone density; calcium bone level; comparative study; controlled study; diastolic blood pressure; drug effect; female; high performance liquid chromatography; hypertension; Indonesia; lipid fingerprinting; mass fragmentography; nonhuman; ovariectomy; plant root; postmenopause; priority journal; protein analysis; rat; rat model; retention time |
Wolters Kluwer Medknow Publications |
01105558 |
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Article |
Q3 |
325 |
14045 |
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No records
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92 |
Habiburrahman M., Ariq H., Handayani R.R.D. |
57204537114;57252668400;57394104600; |
Combining LAMP and Au-Nanoprobe to detect INH-RIF resistance accurately in tuberculosis: An evidence-based review |
2021 |
Journal of Infection in Developing Countries |
15 |
11 |
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1555 |
1568 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122149394&doi=10.3855%2fJIDC.15188&partnerID=40&md5=6f29dbd01464318f481e0062398c92a4 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; National Respiratory Center Persahabatan Hospital, Jakarta, Indonesia |
Habiburrahman, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ariq, H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Handayani, R.R.D., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia, National Respiratory Center Persahabatan Hospital, Jakarta, Indonesia |
Approximately 1.41 million people die annually due to tuberculosis. One of the main problems in Tuberculosis eradication is the development of resistance to various antibiotics. However, current efforts to detect resistances face challenges such as limited equipment, budget, and time. This evidence-based review investigated loop-mediated isothermal amplification, an alternative molecular diagnostic tool with promising performance and applicability in developing countries, and its use combined with Au-Nanoprobe to detect antibiotic resistance in tuberculosis. The literature search was conducted through four databases (Proquest, EBSCOhost, Scopus, and Pubmed) for useful articles on loop-mediated isothermal amplification and Au-Nanoprobe in detecting tuberculosis and tuberculosis resistance. After filtering the result with inclusion and exclusion criteria, the search produced three papers that best answer the clinical question. Loop-mediated isothermal amplification amplifies a target sequence, and Au-Nanoprobe responds to the DNA specific to the target mutant, producing an observable color change. Loop-mediated isothermal amplification and Au-Nanoprobe showed 100% sensitivity and specificity in detecting rifampicin and isoniazid resistance. Another study investigated its viability to detect tuberculosis and found 98.2% sensitivity and 88.2% specificity. Combining loop-mediated isothermal amplification and Au-Nanoprobe had a shorter time to get results and should also be relatively cheaper because it does not need a high temperature to work and requires less equipment. In conclusion, loop-mediated isothermal amplification and Au-Nanoprobe can be used as an efficient and accurate method to detect isoniazid and rifampicin-resistant tuberculosis strains. The new technology is promising for developing countries due to their high disease burden but facing several healthcare barriers. Copyright © 2021 Habiburrahman et al. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Au-Nanoprobes; Diagnosis; Isoniazid; Loop-mediated isothermal amplification; Multidrug-resistant tuberculosis; Rifampicin |
aflatoxin B1; antibiotic agent; betaine; catalase; gold; gold nanoparticle; isoniazid; isoniazid plus rifampicin; penicillin derivative; rifampicin; rifapentine; bacterial DNA; isoniazid; rifampicin; tuberculostatic agent; antibiotic resistance; blood culture; cost effectiveness analysis; developing country; disease burden; DNA extraction; filtration; gene amplification; genotype; high temperature; human; loop mediated isothermal amplification; Medline; molecular diagnosis; multiplex polymerase chain reaction; Mycobacterium tuberculosis; nonhuman; nucleotide sequence; polymerase chain reaction; Review; rifampicin resistance; Scopus; sputum cytodiagnosis; sputum smear; Streptococcus pneumoniae; surface plasmon resonance; systematic review; temperature; tuberculosis; multidrug resistant tube |
Journal of Infection in Developing Countries |
20366590 |
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34898479 |
Review |
Q3 |
322 |
14136 |
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272 |
Rozaliyani A., Sedono R., Sjam R., Tugiran M., Adawiyah R., Setianingrum F., Jusuf A., Sungkar S., Hagen F., Meis J.F., Wahyuningsih R. |
57203065912;56660590500;23398458200;57218291154;57208658742;57203061705;57205710194;57016857300;8050973500;55941779900;6507268400; |
Molecular typing and antifungal susceptibility study of Aspergillus spp. In intensive care unit (ICU) patients in Indonesia |
2021 |
Journal of Infection in Developing Countries |
15 |
7 |
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1014 |
1020 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112486692&doi=10.3855%2fjidc.13135&partnerID=40&md5=1a4e201e605dd6b5e4f597b467372d29 |
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anesthesiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia/Persahabatan Hospital, Jakarta, Indonesia; Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital (CWZ), Nijmegen, Netherlands; Department of Medical Mycology, Westerdijk Fungal Biodiversity Institute, Utrecht, Netherlands; Centre of Expertise in Mycology, Radboudumc/CWZ, Nijmegen, Netherlands; Department of Parasitology, Faculty of Medicine, Universitas Kristen, Jakarta, Indonesia |
Rozaliyani, A., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sedono, R., Department of Anesthesiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sjam, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tugiran, M., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Adawiyah, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setianingrum, F., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jusuf, A., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia/Persahabatan Hospital, Jakarta, Indonesia; Sungkar, S., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hagen, F., Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital (CWZ), Nijmegen, Netherlands, Department of Medical Mycology, Westerdijk Fungal Biodiversity Institute, Utrecht, Netherlands; Meis, J.F., Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital (CWZ), Nijmegen, Netherlands, Centre of Expertise in Mycology, Radboudumc/CWZ, Nijmegen, Netherlands; Wahyuningsih, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Kristen, Jakarta, Indonesia |
Introduction: Aspergillus exhibits a wide variation of susceptibility against antifungals according to genetic and environmental factors. Identification to the species level is necessary for appropriate treatment. Our objective was to determine the Aspergillus species involved in invasive pulmonary aspergillosis (IPA) among ICU patients in Jakarta, Indonesia. Methodology: The incidence of IPA in ICU patients at six hospitals in Jakarta from October 2012 - January 2015 was investigated. It involved a collection of endotracheal aspirates (ETA), nasal swabs and environmental samples around the hospitals, phenotypic screening, molecular characterization, and antifungal susceptibility testing. Results: Of the 405 patients investigated, 31 patients (7.7%) were diagnosed with putative IPA, from whom 45 Aspergillus isolates were collected. Aspergillus isolates were identified from pulmonary secretions in 24 patients, from nasal swabs in 7 patients and from both pulmonary secretions and nasal swabs in 7 patients. The phenotypic method showed 33 isolates of Aspergillus flavus (73.4%), nine Aspergillus fumigatus (20%), two Aspergillus niger (4.4%), and one Aspergillus nidulans (2.2%) isolate. Molecular identification showed 27 isolates of A. flavus (60.0%), eight isolates of A. fumigatus (17.8%), two isolates of A. niger (4.4%) and one isolate of A. nidulans (2.2%), while seven isolates (15.6%) were cryptic species or mixed isolates. Conclusions: Susceptibility testing showed all isolates were susceptible to amphotericin B, azoles and micafungin. Aspergillus flavus was the main causative organism in IPA cases in Jakarta, followed by A. fumigatus. © 2021 Journal of Infection in Developing Countries. All rights reserved. |
Aspergillus; Molecular typing; Susceptibility |
amphotericin B; internal transcribed spacer; isavuconazole; itraconazole; micafungin; microsatellite DNA; posaconazole; pyrrole; voriconazole; antifungal agent; microsatellite DNA; antifungal susceptibility; Article; Aspergillus; Aspergillus flavus; Aspergillus nidulans; Aspergillus niger; Aspergillus tamarii; cohort analysis; controlled study; fungus identification; human; incidence; Indonesia; intensive care unit; invasive aspergillosis; major clinical study; minimum effective concentration; minimum inhibitory concentration; multicenter study; nonhuman; Penicillium citrinum; phenotype; prospective study; Aspergillus; classification; clinical trial; drug effect; environmental microbiology; genetics; Indonesia; invasive aspergillosis; isolation and purification; microbiology; nose mucosa; |
Journal of Infection in Developing Countries |
20366590 |
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34343127 |
Article |
Q3 |
322 |
14136 |
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|
332 |
Faisal H.K.P., Taufik F.F., Sugihen T.T.G., Prasenohadi, Juliani T., Yunus F. |
57216393050;57193061752;57226081615;55758911100;57226064151;57194486277; |
Brief psychotic disorder in COVID-19 patient with no history of mental illness |
2021 |
Journal of Infection in Developing Countries |
15 |
6 |
|
787 |
790 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110348248&doi=10.3855%2fjidc.14830&partnerID=40&md5=12676e465ecf6e71d13eea343a7e6c3f |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia; Department of Psychiatry, Persahabatan Hospital, Jakarta, Indonesia |
Faisal, H.K.P., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia; Taufik, F.F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia; Sugihen, T.T.G., Department of Psychiatry, Persahabatan Hospital, Jakarta, Indonesia; Prasenohadi, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia; Juliani, T., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia; Yunus, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia |
Introduction: COVID-19 pandemic affects mental health globally. Reports showed the increase of mental illness as a response to the COVID-19 pandemic. However, the correlation between the COVID-19 and mental illness is not fully understood yet. Methodology: We reported a brief psychotic disorder in a COVID-19 patient with no history of mental illness who was hospitalized in Persahabatan Hospital, Jakarta, Indonesia. Results: Psychotic symptoms appeared five days after COVID-19 onset and laboratory tests showed elevated levels of d-dimer and fibrinogen. Conclusions: Elevated levels of d-dimer and fibrinogen suggest an ongoing COVID-19-associated coagulopathy that might cause a microdamage in the central nervous system. It might contribute to the manifestation of psychotic symptoms. The correlation between brief psychotic disorder and COVID-19 requires further investigation. Copyright © 2021 Faisal et al. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Acute psychosis; Brief psychotic disorder; COVID-19; Neuropsychiatry |
alanine aminotransferase; amlodipine; ascorbic acid; aspartate aminotransferase; azithromycin; bicarbonate; C reactive protein; creatinine; D dimer; enoxaparin; ferritin; hemoglobin; hydroxychloroquine; lorazepam; oseltamivir; potassium; risperidone; sodium; urea; vitamin D; fibrin degradation product; fibrin fragment D; fibrinogen; activated partial thromboplastin time; adult; Article; auditory hallucination; blood carbon dioxide tension; blood oxygen tension; brief psychotic disorder; case report; clinical article; cold sweat; computer assisted tomography; coronavirus disease 2019; diarrhea; dry cough; dyspnea; glucose blood level; human; hypertension; lymphocyte count; male; medical history; middle aged; nasopharyngeal swab; neutrophil count; platelet count; prothrombin time; reverse tr |
Journal of Infection in Developing Countries |
20366590 |
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34242187 |
Article |
Q3 |
322 |
14136 |
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491 |
Susanto A.D., Triyoga P.A., Isbaniah F., Fairuz A., Cendikiawan H., Zaron F., Aryanti I., Irbah S.N., Hidayat M. |
57190425587;57222896246;36489441300;57222895896;57222896833;57222896488;57222896415;57222896232;56435992700; |
Lung fibrosis sequelae after recovery from COVID-19 infection |
2021 |
Journal of Infection in Developing Countries |
15 |
3 |
|
360 |
365 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104167707&doi=10.3855%2fjidc.13686&partnerID=40&md5=622edaeb2b1f79f472a58df7a7dfdca2 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia; Lung Clinic, Eka Hospital Cibubur, West Java, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Radiology Departement, Eka Hospital Cibubur, West Java, Indonesia; Faculty of Medicine, University of Mataram, Mataram, West Nusa Tenggara, Indonesia |
Susanto, A.D., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia, Lung Clinic, Eka Hospital Cibubur, West Java, Indonesia; Triyoga, P.A., Lung Clinic, Eka Hospital Cibubur, West Java, Indonesia; Isbaniah, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia; Fairuz, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cendikiawan, H., Radiology Departement, Eka Hospital Cibubur, West Java, Indonesia; Zaron, F., Radiology Departement, Eka Hospital Cibubur, West Java, Indonesia; Aryanti, I., Radiology Departement, Eka Hospital Cibubur, West Java, Indonesia; Irbah, S.N., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hidayat, M., Faculty of Medicine, University of Mataram, Mataram, West Nusa Tenggara, Indonesia |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that causes coronavirus diseases 2019 (COVID-19). The SARS-CoV-2 is very contagious and nobody is known to be immune to it. The post-infected lung would leave a scar known as fibrosis, a scar tissue. A study from Wuhan, China suggested the development of fibrosis, though it was too early to label these lung changes as irreversible fibrosis in a time range of 3 weeks. The occurrence of fibrosis indicates a chronic infection which greatly contributes to the hallmark symptom of COVID-19 induced ARDS such as shortness of breath and chest pain. However, many of those studies have not yet explained the condition of the patient's lung after total recovery from the COVID-19. This report demonstrates the clinical symptoms, chest CT scan, spirometry, and blood gas analysis of patient after total recovery from the COVID-19 with appearance lung fibrosis. Copyright © 2021 Susanto et al. |
COVID-19; Lung fibrosis; Recovery |
ascorbic acid plus vitamin B complex; azithromycin; beta 2 adrenergic receptor stimulating agent; chloroquine; corticosteroid; hemoglobin; levofloxacin; meropenem; oseltamivir; adult; adult respiratory distress syndrome; Article; blood gas analysis; breathing rate; case report; cell count; clinical article; computer assisted tomography; coronavirus disease 2019; coughing; dyspnea; fever; forced expiratory volume; forced vital capacity; ground glass opacity; headache; hospitalization; human; lung examination; lung fibrosis; male; middle aged; nose smear; oropharyngeal swab; oxygen saturation; oxygen therapy; physical examination; pneumonia; quality of life; real time polymerase chain reaction; rhinorrhea; Severe acute respiratory syndrome coronavirus 2; spirometry; thorax pain; thorax radio |
Journal of Infection in Developing Countries |
20366590 |
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33839710 |
Article |
Q3 |
322 |
14136 |
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