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712	Rohsiswatmo R., Azharry M., Sari T.T., Bahasoan Y., Wulandari D.	55533574600;57263156500;36519483600;57263337000;57204024903;	TLR2 and TLR4 expressions in late-onset neonatal sepsis: Is it a potential novel biomarker?	2021	Journal of Neonatal-Perinatal Medicine	14	3		361	367	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115150896&doi=10.3233%2fNPM-200411&partnerID=40&md5=6cf4f414e02f524e32c55a2f9864c09a	Department of Child Health, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia	Rohsiswatmo, R., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Azharry, M., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sari, T.T., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bahasoan, Y., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wulandari, D., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia	BACKGROUND: Late-onset neonatal sepsis (LONS) detection is problematic as no single examinations (blood culture, c-reactive protein (CRP), procalcitonin (PCT)) are reliable. Toll-like receptors (TLRs), which detect the presence of pathogen-associated molecular patterns is a promising novel biomarker, but less studied in LONS. This study aimed to determine neutrophils and monocytes TLR2 and TLR4 expression in LONS and their diagnostic value. METHODS: A cross-sectional study conducted in May and June 2017 involving 52 neonates with clinical late-onset (>72 hours of age) sepsis. We examine complete blood count, I/T ratio, CRP, PCT, as well as TLR2 and TLR4 expression to compared with blood culture as the gold standard. We classified cases into proven or unproven sepsis. RESULT: The incidence of LONS was 32.6% in the subjects. The expression of TLR2 was low in LONS, while TLR4 was high. TLR4 neutrophil expression has 88.2% sensitivity, 20% specificity, 34.9% positive predictive value (PPV), 77.8% negative predictive value (NPV), and an AUC of 0.541. TLR4 monocyte expression has 92.1% sensitivity, 11.4% specificity, 34% PPV, 80% NPV, and an AUC of 0.528. The AUC of CRP is increased from 0.608 to 0.843 after combination with TLR4, comparable with CRP + PCT (AUC 0.829). CONCLUSION: The increase in TLR4 expression has good sensitivity but low specificity. TLR4 expression, in combination with CRP, could become a reliable biomarker for the diagnosis of LONS. © 2021-IOS Press. All rights reserved.	biomarker; c-reactive protein; Late-onset neonatal sepsis; procalcitonin; TLR2; TLR4	biological marker; C reactive protein; procalcitonin; toll like receptor 2; toll like receptor 4; biological marker; C reactive protein; TLR2 protein, human; TLR4 protein, human; toll like receptor 2; toll like receptor 4; Acinetobacter baumannii; Article; blood cell count; blood culture; controlled study; cross-sectional study; diagnostic test accuracy study; diagnostic value; female; gold standard; human; Klebsiella pneumoniae; late onset disorder; low birth weight; major clinical study; male; monocyte count; neutrophil count; newborn; newborn sepsis; nonhuman; predictive value; protein expression; receiver operating characteristic; sensitivity and specificity; sepsis; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Humans; Infant, Newborn; Neonatal Sepsis; Sepsis; Toll-Like Rec	IOS Press BV	19345798	33164948	Article	Q2	444	11146	View
727	Pratomo I.P., Noor D.R., Kusmardi K., Rukmana A., Paramita R.I., Erlina L., Fadilah F., Gayatri A., Fitriani M., Purnomo T.T.H., Ariane A., Heryanto R., Tedjo A.	57192904477;57214096801;56966625300;35491487100;54882436900;57190181680;56966708600;57204275086;57233517300;57234248500;57210643323;23392757600;57189320451;	Xanthine Oxidase-Induced Inflammatory Responses in Respiratory Epithelial Cells: A Review in Immunopathology of COVID-19	2021	International Journal of Inflammation	2021		1653392			1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113632856&doi=10.1155%2f2021%2f1653392&partnerID=40&md5=37c46cd8f6ff191ba785fa8abb7052a3	Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; COVID-19 Task Force-Pulmonology and Respiratory Medicine Unit, Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Ipb University, Bogor, Indonesia; Tropical Biopharmaca Research Center, Ipb University, Bogor, Indonesia	Pratomo, I.P., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, COVID-19 Task Force-Pulmonology and Respiratory Medicine Unit, Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Noor, D.R., Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusmardi, K., Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rukmana, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Paramita, R.I., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Erlina, L., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Fadilah, F., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Gayatri, A., Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fitriani, M., Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Purnomo, T.T.H., Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Ariane, A., Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Indonesia; Heryanto, R., Department of Chemistry, Faculty of Mathematics and Natural Sciences, Ipb University, Bogor, Indonesia, Tropical Biopharmaca Research Center, Ipb University, Bogor, Indonesia; Tedjo, A., Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia	Xanthine oxidase (XO) is an enzyme that catalyzes the production of uric acid and superoxide radicals from purine bases: hypoxanthine and xanthine and is also expressed in respiratory epithelial cells. Uric acid, which is also considered a danger associated molecule pattern (DAMP), could trigger a series of inflammatory responses by activating the inflammasome complex path and NF-B within the endothelial cells and by inducing proinflammatory cytokine release. Concurrently, XO also converts the superoxide radicals into hydroxyl radicals that further induce inflammatory responses. These conditions will ultimately sum up a hyperinflammation condition commonly dubbed as cytokine storm syndrome (CSS). The expression of proinflammatory cytokines and neutrophil chemokines may be reduced by XO inhibitor, as observed in human respiratory syncytial virus (HRSV)-infected A549 cells. Our review emphasizes that XO may have an essential role as an anti-inflammation therapy for respiratory viral infection, including coronavirus disease 2019 (COVID-19). © 2021 Irandi Putra Pratomo et al.		allopurinol; uric acid; xanthine oxidase; airway epithelium cell; antiinflammatory activity; catalysis; coronavirus disease 2019; cytokine release; enzyme activity; human; hypoxia; immunopathology; inflammation; neutrophil; nonhuman; pathogenesis; protein function; protein targeting; Review; RNA virus infection	Hindawi Limited	20908040		Review	Q2	1106	3761	View
744	Rinaldi I., Sari R.M., Tedhy V.U., Winston K.	23475122400;57208474079;57226362042;57224165400;	Leukapheresis does not improve early survival outcome of acute myeloid leukemia with leukostasis patients – A dual-center retrospective cohort study	2021	Journal of Blood Medicine	12			623	633	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111261844&doi=10.2147%2fJBM.S312140&partnerID=40&md5=ef2e5f0e39b0ea908c07e71bba0bf1a4	Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, Dharmais National Cancer Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Rinaldi, I., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sari, R.M., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dharmais National Cancer Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tedhy, V.U., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Winston, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Introduction: Leukostasis is a medical emergency with high mortality which often occurs in acute myeloid leukemia patients with hyperleukocytosis. One of the therapies that can be used for leukostasis in acute myeloid leukemia is leukapheresis. However, whether leukapheresis can provide better survival benefit when compared with patients not receiving leukapheresis is still unclear. Hence, we aimed to evaluate the effect of chemotherapy plus leukapheresis combination versus chemotherapy only on 28-day survival of acute myeloid leukemia patients with leukostasis. Methods: This study was a dual-center retrospective cohort using secondary data from medical records collected from November 2018 to March 2019. Inclusion criteria were adult patients aged 18 years old or above, diagnosed with acute leukemia with hyperleukocytosis status defined by WBC count greater than 100,000/uL, and with symptoms of leukostasis. One-month survival analysis was conducted using Kaplan–Meier curve method. Univariate and multivariate analyses were then conducted using Cox proportional hazards model to obtain value of hazard ratio (HR) with a 95% confidence interval (CI). Results: A total of 38 patients were obtained for analysis. The median overall survival was 25 days (95% CI: 17.001–32.999 days) in the chemotherapy only group and 20 days (95% CI: 1.497–38.503) in the chemotherapy with leukapheresis group. The use of leukapheresis did not affect 28-day survival (HR: 1.140; 95% CI: 0.396–3.283; p value: 0.809) and 7-day survival (HR: 1.073; 95% CI: 0.277–4.152; p value: 0.919). In the multivariate analysis, age ≥60 years, blast percentage ≥90%, creatinine ≥1.4 mg/dL, and presence of disseminated intravascular coagulation were associated with worse 28-day survival. Conclusion: AML patients with leukostasis who received both chemotherapy and leuka-pheresis did not have better 28-day survival and 7-day survival when compared with patients receiving chemotherapy only. Old age, high blast percentage, high creatinine, and presence of disseminated intravascular coagulation were prognostic factors for worse 28-day survival. © 2021 Rinaldi et al.	Chemotherapy; Hyperleukocytosis; Leukapheresis; Leukemia; Leukostasis; Survival	creatinine; gluconate calcium; hemoglobin; lactate dehydrogenase; vascular cell adhesion molecule 1; acute myeloid leukemia; adult; allogeneic hematopoietic stem cell transplantation; Article; blood transfusion; cancer prognosis; chronic myeloid leukemia; clinical article; cohort analysis; de novo acute myeloid leukemia; dyspnea; female; heart failure; human; hypertension; hypocalcemia; Kaplan Meier method; leukapheresis; leukocyte count; leukocytosis; leukostasis; lymphocyte count; male; mean corpuscular hemoglobin; mean corpuscular volume; mean platelet volume; observational study; overall survival; platelet count; platelet lymphocyte ratio; pneumothorax; red blood cell distribution width; retrospective study; risk factor; thrombocyte aggregation	Dove Medical Press Ltd	11792736		Article	Q3	676	7401	View
745	Syam A.F.	8443384400;	Gastrointestinal disorders in covid-19 patients: A great imitator	2021	Medical Journal of Indonesia	30	2		166	169	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111112690&doi=10.13181%2fmji.bc.204960&partnerID=40&md5=1e55d25030cd22add972a3dac84c5ac5	Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia	Syam, A.F., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia	Up to this point, the coronavirus disease 2019 (COVID-19) pandemic is still ongoing. Some studies with a large number of cases have reported its clinical manifestations, concluding that the disease is a great imitator. Patients may present with symptoms other than the main symptoms of respiratory tract infections, such as diarrhea, abdominal pain, nausea, or vomiting, which may sometimes cause a delayed treatment in managing COVID-19 patients. Reports of various hospitals have also demonstrated gastrointestinal complaints as a clinical manifestation in those patients. The patients may come with gastrointestinal symptoms as their early clinical manifestation, or the gastrointestinal symptoms may be found in hospitalized COVID-19 patients, which indeed can be explained since the SARS-CoV-2, an etiologic agent of COVID-19 infection, can obviously be found along the gastrointestinal tract. Hence, the virus can be found in fecal and anal, and therefore, rectal swabs can be used as a diagnostic tool for COVID-19 infection. © 2021 Author.	COVID-19; Gastrointestinal disease; SARS-CoV-2	alkaline phosphatase; angiotensin converting enzyme 2; aspartate aminotransferase; transmembrane protease serine 2; virus RNA; anal swab; Article; coronavirus disease 2019; coughing; diabetes mellitus; diarrhea; dyspnea; epigastric pain; feces analysis; fever; gastrointestinal disease; gastrointestinal symptom; gastrointestinal tract; human; hypertension; inflammatory bowel disease; lung lavage; nasopharyngeal swab; nausea and vomiting; nonhuman; pneumonia; real time reverse transcription polymerase chain reaction; rectal swab; RNA virus; Severe acute respiratory syndrome coronavirus 2; stomach pain; thorax radiography; virus transmission	Faculty of Medicine, Universitas Indonesia	08531773		Article	Q4	164	21905	View
752	Pulungan A., Soesanti F., Tridjaja B., Batubara J.	57192905981;37068080600;6504507193;6506167513;	Vitamin D insufficiency and its contributing factors in primary school-aged children in Indonesia, a sun-rich country	2021	Annals of Pediatric Endocrinology and Metabolism	26	2		92	98	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110706480&doi=10.6065%2fapem.2040132.066&partnerID=40&md5=a96cfde3f3454bb64c938819b9dd6387	Department of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia	Pulungan, A., Department of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Soesanti, F., Department of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Tridjaja, B., Department of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Batubara, J., Department of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia	Purpose: The prevalence of rickets is increasing worldwide in association with an increase in vitamin D deficiency. This study aimed to investigate the vitamin D profile of healthy school-aged children in a sun-rich country and its contributing factors. Methods: This cross-sectional study was conducted in 120 healthy children from 7–12 years of age who live in Jakarta, Indonesia. Their demographic status, sun exposure duration time, and lifestyle were recorded using a structured questionnaire. Serum calcium, phosphate, bone-alkaline phosphatase (B-ALP), and 25-hydroxy vitamin D (25(OH)2D3) levels were measured. The participants were categorized into vitamin D sufficient and non-vitamin D sufficient groups, and we analyzed variables that contributed to the 25(OH)2D3 level. Results: Of the participants, 73 (60.8%) were vitamin D sufficient, 45 (37.5%) were vitamin D insufficient, and 2 (1.7%) were vitamin D deficient. Sex, age, body mass index, Fitzpatrick skin type, daily milk intake, and clothing type were not different between the vitamin D sufficient and non-vitamin D sufficient groups. There were no differences in serum calcium, phosphate, and B-ALP between the 2 groups. Sun exposure time was significantly longer in the vitamin D sufficient group compared with that in the non-vitamin D sufficient group (511.4 min/wk vs. 318.7 min/wk, P=0.004), and this effect remained consistent on multivariate analysis after adjustment for covariates (adjusted odds ratio, 1.002; 95% confidence interval, 1.000–1.003). More participants in the vitamin D sufficient group did not use sunscreen (59 vs. 27, P=0.02), but this finding was inconsistent with our multivariate analysis. Conclusion: Despite year-round sun exposure, approximately 1 in 3 primary school-aged children had insufficient vitamin D level. Sun exposure duration was a major contributing factor. © 2021 Annals of Pediatric Endocrinology & Metabolism.	25-Hydroxy vitamin D; Rickets; Sun-rich country; Vitamin D deficiency	25 hydroxyvitamin D; alkaline phosphatase bone isoenzyme; calcifediol; sunscreen; Article; blood analysis; blood sampling; body mass; calcium blood level; child; cross-sectional study; demography; female; human; human cell; human experiment; information processing; major clinical study; male; normal human; nutritional status; phosphate blood level; prevalence; primary school; radioimmunoassay; rickets; school child; skin color; structured questionnaire; sun exposure; vitamin blood level; vitamin D deficiency	Korean society of pediatric endocrinology	22871012		Article	Q2	448	11054	View
755	Rizka A., Indrarespati A., Dwimartutie N., Muhadi M.	57203243658;57226114717;37067234900;57203726712;	Frailty among older adults living in nursing homes in indonesia: Prevalence and associated factors	2021	Annals of Geriatric Medicine and Research	25	2		93	97	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110540813&doi=10.4235%2fagmr.21.0033&partnerID=40&md5=86f7c65e002ab68ffb8c5b85442e968b	Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Division of Cardiovascular, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia	Rizka, A., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Indrarespati, A., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Dwimartutie, N., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Muhadi, M., Division of Cardiovascular, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia	Background: Frailty syndrome is a predictor of all-cause mortality among older adults living in nursing homes. However, data on the prevalence of frailty among individuals living in nursing homes, particularly in middle-income countries, are limited. Thus, this study aimed to determine the prevalence of frailty and identify its associated factors among older adults living in nursing homes in Indonesia. Methods: This cross-sectional study of older adults living in six nursing homes in Indonesia was conducted between May and December 2019. Data on demographic characteristics, physical activity (Physical Activity Scale for the Elderly), cognitive status (Abbreviated Mental Test), nutritional status (Mini Nutritional Assessment Short-Form), depression (Geriatric Depression Scale), comorbidity, frailty state (Cardiovascular Health Study criteria), dietary pattern (24-hour food recall), handgrip strength, and gait speed were evaluated. Bivariate and multivariate analyses were performed to identify factors independently associated with frailty. Results: This study recruited a total of 214 participants with a mean age of 73.68±4.30 years. The prevalence rates of frailty and malnutrition were 46.5% and 58%, respectively. The results showed that physical frailty was associated with malnutrition (odds ratio=4.23; 95% confidence interval, 1.730–10.380). Conclusion: Frailty was prevalent and strongly associated with malnutrition among older adults living in nursing homes in Indonesia. © 2021 by The Korean Geriatrics Society.	Frailty syndrome; Nursing home; Older adult	aged; Article; cognition; cohort analysis; cross-sectional study; depression; dietary pattern; female; frailty; gait; human; Indonesia; male; malnutrition; mental test; Mini-Nutritional Assessment; nursing home; nutritional status; physical activity; prevalence	Korean Geriatrics Society	25084798		Article	Q3	296	14960	View
756	Triwijoyo B.K., Sabarguna B.S., Budiharto W., Abdurachman E.	57193868829;56028625800;36069151100;56820169100;	New Hypertensive Retinopathy Grading Based on the Ratio of Artery Venous Diameter from Retinal Image	2021	International Journal of Computing	20	2		221	227	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110495692&doi=10.47839%2fijc.20.2.2069&partnerID=40&md5=c4614e9182f0c78a92851c2aaa71bc36	Binus Graduate Program Bina Nusantara University, Jl. Kebon Jeruk No.27, Jakarta, Indonesia; Department of Computer Science, Faculty of Engineering and Health, Bumigora University, Jl. Ismail Marzuki,West Nusa Tenggara, Mataram, Indonesia; Department of Community Medicine, Faculty of Medicine, University of Indonesia, Jl. Pegangsaan Timur, Central Jakarta City, Indonesia	Triwijoyo, B.K., Binus Graduate Program Bina Nusantara University, Jl. Kebon Jeruk No.27, Jakarta, Indonesia, Department of Computer Science, Faculty of Engineering and Health, Bumigora University, Jl. Ismail Marzuki,West Nusa Tenggara, Mataram, Indonesia; Sabarguna, B.S., Department of Community Medicine, Faculty of Medicine, University of Indonesia, Jl. Pegangsaan Timur, Central Jakarta City, Indonesia; Budiharto, W., Binus Graduate Program Bina Nusantara University, Jl. Kebon Jeruk No.27, Jakarta, Indonesia; Abdurachman, E., Binus Graduate Program Bina Nusantara University, Jl. Kebon Jeruk No.27, Jakarta, Indonesia	Medical research indicated that narrowing of the retinal blood vessels might be an early indicator of cardiovascular diseases; one of them is hypertensive retinopathy. This paper proposed the new staging method of hypertensive retinopathy by measure the ratio of diameter artery and vein (AVR). The dataset used in this research is the public Messidor color fundus image dataset. The proposed method consists of image resizing using bicubic interpolation, optic disk detection, a region of interest computation, vessel diameter measuring, AVR calculation, and grading the new categories of Hypertensive Retinopathy based on Keith-Wagener-Barker categories. The experiments show that the proposed method can determine the stage of hypertensive retinopathy into new categories. © 2021. All Rights Reserved.	artery-vein diameter ratio; grading; hypertensive retinopathy		Research Institute of Intelligent Computer Systems	17276209		Article	Q3	184	20423	View
761	Lesmana C.R.A., Paramitha M.S., Gani R.A.	8977683000;57212562901;23495930300;	The Role of Interventional Endoscopic Ultrasound in Liver Diseases: What Have We Learnt?	2021	Canadian Journal of Gastroenterology and Hepatology	2021		9948979			1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110213187&doi=10.1155%2f2021%2f9948979&partnerID=40&md5=a038d06d78df9e699aa4a27ead88d0bb	Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia; Digestive Disease and GI Oncology Center, Medistra Hospital, Jakarta, Indonesia	Lesmana, C.R.A., Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia, Digestive Disease and GI Oncology Center, Medistra Hospital, Jakarta, Indonesia; Paramitha, M.S., Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia; Gani, R.A., Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia	Chronic liver disease (CLD) is still a major problem, where the disease progression will lead to liver cirrhosis (LC) or hepatocellular carcinoma (HCC). Portal hypertension (PH) management and loco-regional therapy for HCC have become the cornerstones in advanced liver disease management. Recently, there are studies looking at the potential role of interventional endoscopic ultrasound (EUS) in liver diseases. EUS may be useful in vascular changes of the digestive wall evaluation, performing dynamic assessment of hemodynamic changes, predicting variceal bleeding and rebleeding risk, and assessing the pharmacological effects. In PH management, EUS-guided vascular therapy - which revolves around glue injection, endovascular coil placement/embolization, and combination of both - has shown promising results. As a diagnostic modality for liver cancer, the implementation of EUS in liver diseases is currently not only limited to liver biopsy (EUS-LB) but also in shear-wave elastography (SWE) and portal pressure gradient measurement, as well as portal vein sampling. The application of EUS-guided radiofrequency ablation (EUS-RFA) and tumor injection can also overcome the limitations shown by both modalities without EUS. Nevertheless, establishing EUS as a firm diagnostic and therapeutic modality is still challenging since the performance of interventional EUS requires high expertise and adequate facilities. © 2021 Cosmas Rinaldi A. Lesmana et al.		azygos vein; brachytherapy; chronic liver disease; contrast-enhanced ultrasound; cryotherapy; Doppler flowmetry; elastography; endoscopic ultrasonography; gastrointestinal hemorrhage; human; liver abscess; liver biopsy; liver cirrhosis; liver injury; liver metastasis; nonhuman; paracentesis; peritonitis; portal vein blood pressure; predictive value; radiation exposure; regional perfusion; Review; risk assessment; sclerotherapy; sensitivity and specificity; shear wave elastography; splanchnic blood flow; diagnostic imaging; endoscopic ultrasonography; esophagus varices; interventional ultrasonography; liver cell carcinoma; liver tumor; tumor recurrence; Carcinoma, Hepatocellular; Endosonography; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Liver Neoplasms; Neoplasm R	Hindawi Limited	22912789	34258255	Review	Q2	921	4950	View
767	Bachtiar E.W., Bachtiar B.M., Theodorea C.F., Tahapary D.L., Astrella C., Natalina N.	6507328763;15831189400;57190048861;55944492500;57210793320;57225210620;	A pilot study of red complex and three genera subgingival microbiome in periodontitis subjects with and without diabetes, evaluated by MinION platform	2021	F1000Research	10		79			1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109577307&doi=10.12688%2ff1000research.28216.3&partnerID=40&md5=83c85f319460a8e5631506acfe142095	Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia	Bachtiar, E.W., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Bachtiar, B.M., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Theodorea, C.F., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Tahapary, D.L., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Astrella, C., Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Natalina, N., Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia	Background: Subgingival niche is one biofilm habitat containing rich microbiota, which plays an active role in maintaining the health of periodontal tissue and determining host response. As such, a study of changing subgingival biofilms is important for understanding the effect of a systemic condition. In this study, we compared the occurrence of six bacteria cohabiting in the subgingival area of periodontitis subjects, with (DP, n = 8) and without (NDP, n = 4) diabetes. Methods: The six genus and species of targeted bacteria were confirmed by 16S rRNA amplicon sequencing on MinION nanopore platform. Descriptive statistic was used to describe the obtained data. Results: We found that the six genus and species of targeted bacteria were detected but in different quantities in either group's periodontal pocket. Our data showed that Tannerella forsythia was the most abundant species in subgingival biofilms of the DP group of the red complex bacteria. In contrast, Aggregatibacter sp., which belongs to the phylum of proteobacteria, was present at a relatively lower level. In contrast, Fusobacterium sp., which belongs to orange complex bacteria, showed relative similarities in subgingival biofilms of both groups tested, while Veillonella sp., were abundant in the DP groups. Conclusions: Our data show that the diversity of classic periodontopathogens increased in the subgingival niche of periodontitis subjects with diabetes. It is the first study in Indonesia to apply MinION-based, full-length 16S rRNA amplicon sequencing in periodontitis patients with and without diabetes. © 2021 Bachtiar BM et al.	16S rRNA; Diabetes; MinION; Periodontitis; Red Complex bacteria; Subgingival Microbiome	RNA 16S; diabetes mellitus; genetics; gingiva; human; Indonesia; microflora; periodontitis; pilot study; Diabetes Mellitus; Gingiva; Humans; Indonesia; Microbiota; Periodontitis; Pilot Projects; RNA, Ribosomal, 16S	F1000 Research Ltd	20461402	34249333	Article	Q1	1099	3793	View
768	Midoen Y.H., Suryandari D.A., Yunaini L., Susworo R., Auerkari E.I., Freisleben H.-J.	57197805109;6505763338;57192911515;8438653400;10139113000;7003437337;	Epstein-Barr virus nuclear antigen-1 is useful as therapeutic efficacy marker in serum but not in saliva of nasopharyngeal cancer patients who underwent radiotherapy	2021	ecancermedicalscience	15		1254			1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109546581&doi=10.3332%2fECANCER.2021.1254&partnerID=40&md5=debd5ca3a84a84eabb9d16f1bf92fc2d	Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia; Department of Radiotherapy, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jalan Pangeran Diponegoro 71, Jakarta, 10430, Indonesia; Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jalan Salemba Raya 4, Jakarta, 10430, Indonesia; Medical Research Unit, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 4, Jakarta, 10430, Indonesia	Midoen, Y.H., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia; Suryandari, D.A., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia; Yunaini, L., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia; Susworo, R., Department of Radiotherapy, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jalan Pangeran Diponegoro 71, Jakarta, 10430, Indonesia; Auerkari, E.I., Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jalan Salemba Raya 4, Jakarta, 10430, Indonesia; Freisleben, H.-J., Medical Research Unit, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 4, Jakarta, 10430, Indonesia	Introduction: Nasopharyngeal carcinoma (NPC) is a multifactorial disease with genetic, viral, environmental and lifestyle-related risk factors. Epstein-Barr virus (EBV) can promote the oncogenic transformation of an infected cell into malignant. EBV encodes many stimulating products including Epstein-Barr virus nuclear antigen-1 (EBNA-1) which plays a key role in the regulation of gene expression and replication of the genome in the latent period of infection. EBNA-1 in serum and tumour tissue of NPC patients correlates with NPC prognosis. Moreover, the presence of EBV DNA in serum samples from NPC patients' blood circulation can be used as an early marker in the diagnosis of NPC. Objective: The objective of this study was to find effective methods for monitoring the progress of NPC patients undergoing radiotherapy and therapeutic efficacy by observing the changes in EBV DNA in serum and saliva. Methodology: The pre-experimental design compared blood and saliva taken from a pretest and post-test group of NPC patients before and after radiation therapy. The concentration of EBV DNA was measured in the serum and saliva after amplification using quantitative polymerase chain reaction (qPCR) with compatible primers for the EBNA-1 gene. The data were statistically analysed by paired T-test. Results: Highly significant (p = 0.0001) increase in cycle threshold qPCR and decrease in the mean concentration of EBV DNA (p = 0.0001) were observed in serum samples, but no significant changes were observed in saliva. Conclusions: The results suggest that EBV DNA in serum can be used as the gold standard and a marker for monitoring the response to radiation therapy in NPC patients, whereas the examination of EBV DNA from saliva samples is not accurate and thus, not appropriate. © 2021 ecancer Global Foundation. All rights reserved.	CT; EBNA-1; EBV DNA; NPC; QPCR		ecancer Global Foundation	17546605		Article	Q3	708	7022	View

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