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305 |
Firdaus M.D., Artanti N., Hanafi M., Rosmalena |
57226243708;14832374300;26644895300;56891769500; |
Phytochemical constituents, and in vitro antidiabetic and antioxidant properties of various extracts of kenikir (cosmos caudatus) leaves |
2021 |
Pharmacognosy Journal |
13 |
4 |
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890 |
895 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110937044&doi=10.5530%2fpj.2021.13.114&partnerID=40&md5=90452554ceab08be4e58b8af98f14dc7 |
Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia; Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPITEK, Serpong, Banten, South Tangerang, Indonesia |
Firdaus, M.D., Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia; Artanti, N., Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPITEK, Serpong, Banten, South Tangerang, Indonesia; Hanafi, M., Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPITEK, Serpong, Banten, South Tangerang, Indonesia; Rosmalena, Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Type 2 diabetes mellitus (T2DM) is one of the most common degenerative disorders. For therapeutic use, herbs are commonly used in Indonesia for T2DM treatment, one of them is (Cosmos caudatus) kenikir's leaves. In previous studies, kenikir's leaves have high antidiabetic and antioxidant activity. However, a comparison of antidiabetic activity from many extracts of kenikir's leave is remain unclear. This study will compare the antidiabetic and antioxidant properties of various kenikir's leave extract. Kenikir's leaves are extracted by maceration methods for three days using three different solvents: boiling water, 50% ethanol, dan ethanol 100%.Then, phenolic and flavonoid content will be measured, as well as antioxidant properties by DPPH radical scavenging activity assay, and antidiabetic properties by α-glucosidase inhibition assay, also LCMS/MS will be used to predict the compound from each extract. The result shows that 50% ethanol extract has highest phenolic and flavonoid content than others. It also has significantly higher antioxidant (p<0.05) and antidiabetic (p<0.05) properties than others. Meanwhile, LCMS/MS result of 50% ethanol extract predicts 6 chemical component, that quercetin is the most dominant compound. 50% ethanol extract of kenikir's leaves is superior from other extracts on phenolic and flavonoid content, antioxidant properties, and antidiabetic properties. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
α-Glucosidase |
1,1 diphenyl 2 picrylhydrazyl; 2 beta 3 beta dihydroxy nortropane; alcohol; alpha glucosidase; antidiabetic agent; antioxidant; Cosmos caudatus extract; delta humulene; digiprolactone; flavonoid; genistin; gentiatibetine; glucopyranoside; herbaceous agent; oroxin B; phenol; phenylproprionic acid; phytochemical; plant extract; quercetin; solvent; spathulenol; stearidonic acid; unclassified drug; valine; water; antidiabetic activity; antioxidant activity; Article; boiling point; controlled study; Cosmos (genus); DPPH radical scavenging assay; human; in vitro study; Kenikir leaf; liquid chromatography-mass spectrometry; nonhuman; plant leaf |
EManuscript Technologies |
09753575 |
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Article |
Q3 |
268 |
15961 |
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306 |
Rosmalena, Widyastuti P.A., Yazid F., Ambarwati N.S.S., Ahmad I. |
56891769500;57226249984;57207890516;57193830343;57190669391; |
Phytochemicals and antioxidant activities evaluation of origanum vulgare (L.) stem bark extracts |
2021 |
Pharmacognosy Journal |
13 |
4 |
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965 |
970 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110932652&doi=10.5530%2fpj.2021.13.124&partnerID=40&md5=01f50c35c8a94d648081fcd99e50d8fa |
Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Medical Student, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Department of Cosmetology, Faculty of Engineering, Universitas Negeri Jakarta, East Jakarta, Jakarta, 13220, Indonesia; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, East Kalimantan, Samarinda, 75119, Indonesia |
Rosmalena, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Widyastuti, P.A., Medical Student, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Yazid, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Ambarwati, N.S.S., Department of Cosmetology, Faculty of Engineering, Universitas Negeri Jakarta, East Jakarta, Jakarta, 13220, Indonesia; Ahmad, I., Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, East Kalimantan, Samarinda, 75119, Indonesia |
The present study aimed to evaluate phytochemical and antioxidant activity (in vitro and in vivo) of Origanum vulgare (L.) ethanolic extract. The phytochemical test was assessed using the Clule method in ethanol, ethyl acetate, and hexane. In vitro evaluation of antioxidant activity was determined by radical scavenging assay using DPPH (2,2-diphenyl-1-picrylhydrazyl) as an artificial free radical activity. In vivo test was conducted to evaluate the effect of malondialdehyde (MDA) level in blood plasma during maximum physical activity treatment. In vivo test was done using 25 male Sprague Dawley rats in pre and post-test control group design. The phytochemical test of O. vulgare ethanol extract was showed some compounds, such as a flavonoid, alkaloid, triterpenoid/steroid, essential oil, and tannin, then in ethyl acetate and hexane. In vitro assay showed that O. vulgare extract has strong antioxidant activity with an IC50 value of 133.47 µg/mL. While in the in vivo test, the most effective dosage is 20 mg/200 gr B.W., represented by a significant decrease of MDA level (0.509 nmol/mL) before and after treatment. So, the ethanolic extract of clove has potency as an herbal antioxidant because of the low level of IC50 and can decrease the MDA level. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
2; 2-diphenyl-1-picrylhydrazyl; Antioxidant activity; Malondialdehyde; Origanum vulgare (L.); Phytochemical |
1,1 diphenyl 2 picrylhydrazyl; acetic acid ethyl ester; alcohol; alkaloid; antioxidant; ascorbic acid; essential oil; flavonoid; free radical; hexane; malonaldehyde; Origanum vulgare ethanolic extract; phytochemical; plant extract; saponin; steroid; tannin; triterpenoid; unclassified drug; animal experiment; animal tissue; antioxidant activity; Article; bark; blood sampling; clove; controlled study; DPPH radical scavenging assay; drug potency; in vitro study; in vivo study; male; nonhuman; physical activity; pretest posttest design; rat; Sprague Dawley rat |
EManuscript Technologies |
09753575 |
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Article |
Q3 |
268 |
15961 |
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325 |
Gondhowiardjo S.A., Handoko, Tham I., Giselvania A., Bilimagga R.S., Octavianus S., Hiraoka M., Jayalie V.F., Tamaki T., Calaguas M., Nakano T. |
6508327402;57209984822;56736361800;57217201891;16038470700;57217198334;57202560109;57195939736;18538545200;8452403700;35353843800; |
Regional collaboration to improve quality of radiation therapy in Asia |
2021 |
Journal of Medical Imaging and Radiation Oncology |
65 |
4 |
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424 |
430 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097537491&doi=10.1111%2f1754-9485.13133&partnerID=40&md5=d4d03b15e65e131d0dbd6e9674b257d4 |
Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Radiation Oncology Centre, Mt Elizabeth Novena Hospital, Singapore City, Singapore; Department of Radiation Oncology, HealthCare Global (HCG) Enterprises (Bangalore Institute of Oncology), Bangalore, Karnataka, India; Department of Radiation Oncology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan; Department of Radiation Oncology, Fukushima Medical University, Fukushima, Japan; Division of Radiation Oncology, Department of Radiology, University of the Philippines, Philippine General Hospital, Manila, Philippines; Quantum Medical Science Directorate, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan |
Gondhowiardjo, S.A., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Handoko, Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Tham, I., Radiation Oncology Centre, Mt Elizabeth Novena Hospital, Singapore City, Singapore; Giselvania, A., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Bilimagga, R.S., Department of Radiation Oncology, HealthCare Global (HCG) Enterprises (Bangalore Institute of Oncology), Bangalore, Karnataka, India; Octavianus, S., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Hiraoka, M., Department of Radiation Oncology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan; Jayalie, V.F., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Tamaki, T., Department of Radiation Oncology, Fukushima Medical University, Fukushima, Japan; Calaguas, M., Division of Radiation Oncology, Department of Radiology, University of the Philippines, Philippine General Hospital, Manila, Philippines; Nakano, T., Quantum Medical Science Directorate, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan |
In Asia, several challenges hinder the delivery of high-quality cancer treatment, especially radiation therapy (RT). Many Asian countries face large-scale shortage of RT centres and treatment machines. Additionally, there is also a significant technological gap, with many RT centres in Asia still using outdated technology. There is an urgent need to improve radiation treatment quality in Asia. The Federation of Asian Organizations for Radiation Oncology (FARO) was set up to foster regional collaboration, which we believe can help to identify and solve some of these issues collectively. This report describes the background and rationale of starting FARO, and puts forth some of the early achievements of the group, including fact-finding and educational activities. Finally, we discuss future possibilities, including strategic proposals that may benefit the RT community and our patients in Asia. © 2020 The Royal Australian and New Zealand College of Radiologists |
Asia; cancer; quality; radiation therapy; regional collaboration |
achievement; adult; article; Asia; cancer radiotherapy; human; organization; radiation oncology; radiotherapy; Asia; radiation oncology; Asia; Humans; Radiation Oncology |
Blackwell Publishing |
17549477 |
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33319494 |
Review |
Q3 |
310 |
14491 |
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327 |
Pranata R., Vania A., Vania R., Victor A.A. |
57201973901;57215722420;57208328436;57191055282; |
Intravitreal ranibizumab versus dexamethasone implant in macular edema due to branch retinal vein occlusion: Systematic review and meta-analysis |
2021 |
European Journal of Ophthalmology |
31 |
4 |
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1907 |
1914 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089198137&doi=10.1177%2f1120672120947595&partnerID=40&md5=2317b4b6003baf17ce61244daa301bb4 |
Universitas Pelita Harapan, Tangerang, Banten, Indonesia; Universitas Kristen Krida WacanaWest Jakarta, Indonesia; Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, National General Hospital, Jakarta, Daerah Istimewa Jakarta, Indonesia |
Pranata, R., Universitas Pelita Harapan, Tangerang, Banten, Indonesia; Vania, A., Universitas Kristen Krida WacanaWest Jakarta, Indonesia; Vania, R., Universitas Pelita Harapan, Tangerang, Banten, Indonesia; Victor, A.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, National General Hospital, Jakarta, Daerah Istimewa Jakarta, Indonesia |
Purpose: Intravitreal ranibizumab (RNB) and dexamethasone intravitreal implant (DII) were developed in the recent past and has been widely used for macular edema secondary to BRVO. We aimed to assess the efficacy and safety of intravitreal ranibizumab (RNB) compared to dexamethasone intravitreal implant (DII) in patients with macular edema secondary to branch retinal vein occlusion (BRVO). Methods: We performed a comprehensive search on topics that assess RNB and DII in patients with macular edema secondary to BRVO from several electronic databases. Results: There were 678 subjects from five studies. Ranibizumab was associated with a greater increase in best-corrected visual acuity (BCVA; mean difference 9.13, I2: 0%) compared to DII. Ranibizumab also demonstrated a greater ⩾10 (OR 2.76, I2: 0%) and ⩾15 letters (OR 2.78, I2: 0%) gain. RNB has better BCVA (logMAR scale) improvement at 6 months’ follow up (mean difference −0.15, I2: 64%) in favor of RNB. Higher IOP was found in DII group on follow-up (mean difference −2.92, I2: 89%) and RNB has lesser IOP ⩾10 mmHg increase compared to DII (OR 0.08, I2: 0%). Cataract formation and/or progression was less in RNB (OR 0.53, I2: 75%). The need for rescue laser was similar the two groups. Conclusion: Intravitreal RNB was more effective with less pronounced effect on IOP and cataract formation and/or progression compared to DII for patients with macular edema secondary to BRVO. © The Author(s) 2020. |
branch retinal vein occlusion; dexamethasone; Intravitreal; macular edema; ranibizumab |
dexamethasone; ranibizumab; angiogenesis inhibitor; dexamethasone; glucocorticoid; ranibizumab; Article; best corrected visual acuity; branch retinal vein occlusion; cataract extraction; central retinal thickness; comparative effectiveness; controlled study; cost effectiveness analysis; disease exacerbation; drug safety; Early Treatment Diabetic Retinopathy Study; follow up; human; intervention study; intraocular pressure; macular edema; meta analysis; qualitative analysis; quality control; randomized controlled trial (topic); retina vein occlusion; retinal thickness; sensitivity analysis; systematic review; visual acuity; complication; intravitreal drug administration; macular edema; retina vein occlusion; treatment outcome; Angiogenesis Inhibitors; Dexamethasone; Glucocorticoids; Humans; |
SAGE Publications Ltd |
11206721 |
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32757629 |
Article |
Q2 |
790 |
6120 |
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454 |
Siste K., Hanafi E., Sen L.T., Wahjoepramono P.O.P., Kurniawan A., Yudistiro R. |
55644113100;56737010600;57219034101;57216247534;56521213900;57041205200; |
Erratum: Potential correlates of internet gaming disorder among Indonesian medical students: Cross-sectional study (Journal of Medical Internet Research (2021) 23:4 (e25468) DOI: 10.2196/25468) |
2021 |
Journal of Medical Internet Research |
23 |
4 |
e29790 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105627812&doi=10.2196%2f29790&partnerID=40&md5=81d33d24852e7aee04557d088a3802cd |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Siloam Hospitals, Tangerang, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Pelita Harapan, Siloam Hospital, Tangerang, Indonesia |
Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hanafi, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sen, L.T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wahjoepramono, P.O.P., Faculty of Medicine, Universitas Pelita Harapan, Siloam Hospitals, Tangerang, Indonesia; Kurniawan, A., Department of Internal Medicine, Faculty of Medicine, Universitas Pelita Harapan, Siloam Hospital, Tangerang, Indonesia; Yudistiro, R., Faculty of Medicine, Universitas Pelita Harapan, Siloam Hospitals, Tangerang, Indonesia |
In “Potential Correlates of Internet Gaming Disorder Among Indonesian Medical Students: Cross-sectional Study” (J Med Internet Res 2021;23(4):e25468) the authors noted two errors. Due to a system error, the name of one author, Andree Kurniawan, was replaced with the name of another author on the paper, Ryan Yudistiro. In the originally published paper, the order of authors was listed as follows: Kristiana Siste; Enjeline Hanafi; Lee Thung Sen; Petra Octavian Perdana Wahjoepramono; Ryan Yudistiro; Ryan Yudistiro This has been corrected to: Kristiana Siste; Enjeline Hanafi; Lee Thung Sen; Petra Octavian Perdana Wahjoepramono; Andree Kurniawan; Ryan Yudistiro In the originally published paper, the ORCID number of author Ryan Yudistiro was incorrectly published as follows: 0000-0002-5219-9029 This has been corrected to: 0000-0003-1418-2661 The correction will appear in the online version of the paper on the JMIR Publications website on April 21, 2021, together with the publication of this correction notice. Because this was made after submission to PubMed, PubMed Central, and other full-text repositories, the corrected article has also been resubmitted to those repositories. © Kristiana Siste, Enjeline Hanafi, Lee Thung Sen, Petra Octavian Perdana Wahjoepramono, Andree Kurniawan, Ryan Yudistiro. |
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erratum |
JMIR Publications Inc. |
14388871 |
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33882024 |
Erratum |
Q1 |
1446 |
2408 |
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457 |
Rozaliyani A., Setianingrum F., Azahra S., Abdullah A., Fatril A.E., Rosianawati H., Burhan E., Handayani D., Arifin A.R., Zaini J., Tugiran M., Adawiyah R., Syam R., Wibowo H., Wahyuningsih R., Kosmidis C., Denning D.W. |
57203065912;57203061705;57219977463;57223138415;57223130315;57220203100;36058554600;57219413838;57223139966;57221833355;57218291154;57208658742;57218290535;57217690943;6507268400;16834840500;57223404509; |
Performance of ldbio aspergillus wb and ict antibody detection in chronic pulmonary aspergillosis |
2021 |
Journal of Fungi |
7 |
4 |
311 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105015900&doi=10.3390%2fjof7040311&partnerID=40&md5=d403a899e390ae45f6c1071eeb2d4832 |
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Pulmonary Mycosis Centre, Jakarta, 10430, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, 13230, Indonesia; MH Thamrin Hospital, Jakarta, 10440, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Kristen, Jakarta, 13530, Indonesia; Manchester Academic Health Science Centre, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, School of Biological Sciences, Medicine and Health, University of Manchester, Manchester, M23 9LT, United Kingdom |
Rozaliyani, A., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Pulmonary Mycosis Centre, Jakarta, 10430, Indonesia; Setianingrum, F., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Pulmonary Mycosis Centre, Jakarta, 10430, Indonesia; Azahra, S., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Abdullah, A., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Fatril, A.E., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Rosianawati, H., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, 13230, Indonesia; Burhan, E., Pulmonary Mycosis Centre, Jakarta, 10430, Indonesia, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, 13230, Indonesia; Handayani, D., Pulmonary Mycosis Centre, Jakarta, 10430, Indonesia, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, 13230, Indonesia; Arifin, A.R., Pulmonary Mycosis Centre, Jakarta, 10430, Indonesia, MH Thamrin Hospital, Jakarta, 10440, Indonesia; Zaini, J., Pulmonary Mycosis Centre, Jakarta, 10430, Indonesia, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, 13230, Indonesia; Tugiran, M., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Pulmonary Mycosis Centre, Jakarta, 10430, Indonesia; Adawiyah, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Pulmonary Mycosis Centre, Jakarta, 10430, Indonesia; Syam, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Pulmonary Mycosis Centre, Jakarta, 10430, Indonesia; Wibowo, H., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Pulmonary Mycosis Centre, Jakarta, 10430, Indonesia; Wahyuningsih, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Pulmonary Mycosis Centre, Jakarta, 10430, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Kristen, Jakarta, 13530, Indonesia; Kosmidis, C., Manchester Academic Health Science Centre, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, School of Biological Sciences, Medicine and Health, University of Manchester, Manchester, M23 9LT, United Kingdom; Denning, D.W., Manchester Academic Health Science Centre, Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, School of Biological Sciences, Medicine and Health, University of Manchester, Manchester, M23 9LT, United Kingdom |
The detection of Aspergillus antibody has a key role in the diagnosis of chronic pulmonary as-pergillosis. Western blot (WB) and immunochromatography (ICT) lateral flow detection of Aspergillus antibody can be used as confirmatory and screening assays but their comparative performance in TB patients is not known. This study investigated the performance of these assays among 88 post-tuberculosis patients with suspected CPA. Sensitivity, specificity, receiver operating curve (ROC), area under-curve (AUC) and the agreement between two assays were evaluated. Both WB and ICT showed good sensitivity (80% and 85%, respectively) for detection of Aspergillus antibodies. Substantial agreement (0.716) between these assays was also obtained. The highest AUC result (0.804) was achieved with the combination of WB and ICT. The global intensity of WB correlated with the severity of symptoms in CPA group (p = 0.001). The combination of WB and ICT may increase specificity in CPA diagnosis. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Chronic pulmonary aspergillosis; Immunochromatography; Western blot |
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MDPI AG |
2309608X |
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Article |
Q1 |
1702 |
1800 |
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460 |
Darmaputra D.C., Zaman F.Y., Khu Y.L., Nagalingam V., Liew D., Aung A.K. |
57223041347;57208759841;57208757691;57215386437;7003970080;55117996600; |
Cost-analysis of opportunistic influenza vaccination in general medical inpatients |
2021 |
Internal Medicine Journal |
51 |
4 |
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591 |
595 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104572736&doi=10.1111%2fimj.15270&partnerID=40&md5=6be726bbda46f6b4342a09dd962a3b11 |
Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia |
Darmaputra, D.C., Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Zaman, F.Y., Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia; Khu, Y.L., Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia; Nagalingam, V., Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia; Liew, D., School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia, Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia; Aung, A.K., School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia, Department of General Medicine, The Alfred Hospital, Melbourne, VIC, Australia |
Influenza vaccination is an important preventative health measure in the elderly and those with medical comorbidities. It has been shown to reduce hospitalisations, cardiovascular and respiratory complications. A significant proportion of patients admitted to general medicine are eligible for opportunistic inpatient influenza vaccination. This study explores the cost-effectiveness of such a strategy in reducing subsequent healthcare utilisation costs. © 2021 Royal Australasian College of Physicians |
cost-analysis; elderly; influenza; inpatient; vaccination |
aged; article; cost effectiveness analysis; health care utilization; hospital patient; human; influenza vaccination; cost benefit analysis; hospital patient; hospitalization; influenza; vaccination; influenza vaccine; Aged; Cost-Benefit Analysis; Hospitalization; Humans; Influenza Vaccines; Influenza, Human; Inpatients; Vaccination |
Blackwell Publishing |
14440903 |
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33890379 |
Article |
Q3 |
596 |
8475 |
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461 |
Prasetyo M., Adistana I.M., Setiawan S.I. |
57192905252;57223019188;57195939543; |
Tuberculous septic arthritis of the hip with large abscess formation mimicking soft tissue tumors: A case report |
2021 |
Heliyon |
7 |
4 |
e06815 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104438407&doi=10.1016%2fj.heliyon.2021.e06815&partnerID=40&md5=e543449bd0c6c3d5e0c816cffc92a0e4 |
Department of Radiology, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Prasetyo, M., Department of Radiology, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Adistana, I.M., Department of Radiology, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Setiawan, S.I., Department of Radiology, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Background: Tuberculous septic arthritis is an infection that occurs inside the joint or synovial fluid and joint tissues caused by Mycobacterium tuberculosis. It may show wide variability of clinical symptoms and imaging appearance, ranging from asymptomatic with a normal radiographic examination to severe joint pain along with joint destruction, osteomyelitis, and abscess formation. This article presents radiographic and MR imaging appearance from a case of tuberculous septic arthritis with large abscess formation mimicking soft tissue tumor. Case presentation: We reported a 32-year-old female with a slowly enlarging lump on her right proximal thigh within the last 4 months along with slowly progressing joint pain. Both radiographic and MR images showed destruction of the femoral head and acetabular roof, with a formation of large rim-enhanced abscess that extending superficially and distally until mid-thigh. The patient underwent open drainage surgery and excisional biopsy. Histopathological examination showed chronic granulomatous inflammation caused by tuberculous infection. Conclusion: MR imaging combined with radiographic and clinical information played a very important role in the diagnosis of tuberculous septic arthritis with abscess, and to differentiate it from soft tissue neoplasms. © 2021 The Author(s) |
Abscess; Infectious arthritis; Septic arthritis; Tuberculosis |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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462 |
Siste K., Hanafi E., Sen L.T., Wahjoepramono P.O.P., Kurniawan A., Yudistiro R. |
55644113100;56737010600;57219034101;57216247534;56521213900;57041205200; |
Potential correlates of internet gaming disorder among Indonesian medical students: Cross-sectional study |
2021 |
Journal of Medical Internet Research |
23 |
4 |
e25468 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104418234&doi=10.2196%2f25468&partnerID=40&md5=9877dd97d733cb4ea58465ec70c69a79 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Siloam Hospitals, Tangerang, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Pelita, Harapan Siloam Hospital, Tangerang, Indonesia |
Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hanafi, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sen, L.T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wahjoepramono, P.O.P., Faculty of Medicine, Universitas Pelita Harapan, Siloam Hospitals, Tangerang, Indonesia; Kurniawan, A., Department of Internal Medicine, Faculty of Medicine, Universitas Pelita, Harapan Siloam Hospital, Tangerang, Indonesia; Yudistiro, R., Faculty of Medicine, Universitas Pelita Harapan, Siloam Hospitals, Tangerang, Indonesia |
Background: Internet gaming disorder has been a controversial topic for nearly a decade. Although internet addiction has been studied in medical students, there is a paucity of evidence regarding internet gaming disorder. Previous studies in Indonesia explored only the prevalence rate and characteristics. Objective: This study aimed to determine the prevalence rate of internet gaming disorder and correlations between internet gaming disorder, temperament, and psychopathology among Indonesian medical students. Methods: A cross-sectional study was performed from August 2019 to September 2019 using total and convenience sampling at a private university and a public university, respectively. The study variables were measured using the Indonesian version of the 10-item Internet Gaming Disorder Test, the Temperament and Character Inventory, and the Symptoms Checklist 90. Chi-square and logistic regression analyses were conducted to examine the relationships between demographic factors, temperament, psychopathology, and the presence of internet gaming disorder. Results: Among the 639 respondents, the prevalence rate of internet gaming disorder was 2.03% (n=13), with a mean age of 20.23 (SD 0.13) years and an average gaming duration of 19.0 (SD 0.96) hours/week. Up to 71.2% respondents played using their mobile phones, and respondents with internet gaming disorder reported experiencing all psychopathologies assessed, except phobic anxiety. Bivariate analysis demonstrated that internet gaming disorder was associated with gender, gaming duration, gaming community affiliation, and 9 out of 10 domains of psychopathology. In a logistic regression model, internet gaming disorder was correlated with weekly gaming hours ≥20 hours (odds ratio [OR] 4.21, 95% CI 1.08-16.38, P=.04). Conclusions: These findings suggest that the prevalence of internet gaming disorder among medical students in Jakarta, Indonesia is similar to that in other populations of Asian countries. The predisposing factor for internet gaming disorder was weekly gaming duration, while other demographic, temperament, and psychopathology variables acted as probable moderators. Strategies should, therefore, be developed and integrated into medical curriculum to screen and aid individuals with these predisposing factors. © Kristiana Siste, Enjeline Hanafi, Lee Thung Sen, Petra Octavian Perdana Wahjoepramono, Ryan Yudistiro, Ryan Yudistiro. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 19.04.2021. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in the Journal of Medical Internet Research, is properly cited. The complete bibliographic information, a link to the original publication on http://www.jmir.org/, as well as this copyright and license information must be included. |
Internet gaming disorder; Medical students; Psychopathology; Risk factors; Temperament |
adult; anxiety disorder; Article; comparative study; correlational study; cross-sectional study; demography; depression; disease association; female; game addiction; hostility; human; Indonesia; internet gaming disorder test; major clinical study; male; medical student; mental disease assessment; neuropathology; obsessive compulsive disorder; online game; paranoia; prevalence; questionnaire; sex difference; somatization; Symptom Checklist 90; temperament; temperament and character inventory; young adult; addiction; Internet; internet addiction; video game; Adult; Behavior, Addictive; Cross-Sectional Studies; Humans; Indonesia; Internet; Internet Addiction Disorder; Students, Medical; Video Games; Young Adult |
JMIR Publications Inc. |
14388871 |
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Nurhayati F., Anggriani Y., Syahruddin E., Ramadaniati H.U., Kusumaeni T. |
57222957631;57144482600;6507688750;56380618600;57196083946; |
Cost-effectiveness analysis of tyrosine kinase inhibitors (erlotinib vs. gefitinib vs. afatinib) in non-small-cell lung cancer |
2021 |
Journal of Applied Pharmaceutical Science |
11 |
4 |
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88 |
95 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104274393&doi=10.7324%2fJAPS.2021.110411&partnerID=40&md5=b2ac85fabd74afa9ddcab3ce12766f43 |
Pharmacy Department, Persahabatan Government Hospital, Jakarta, Indonesia; Faculty of Pharmacy, University of Pancasila, Jakarta Selatan, Indonesia; Division of Thoracic Oncology Department of Pulmonology Respiratory Medicine Faculty of Medicine, Universitas Indonesia Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Nurhayati, F., Pharmacy Department, Persahabatan Government Hospital, Jakarta, Indonesia; Anggriani, Y., Faculty of Pharmacy, University of Pancasila, Jakarta Selatan, Indonesia; Syahruddin, E., Division of Thoracic Oncology Department of Pulmonology Respiratory Medicine Faculty of Medicine, Universitas Indonesia Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Ramadaniati, H.U., Faculty of Pharmacy, University of Pancasila, Jakarta Selatan, Indonesia; Kusumaeni, T., Pharmacy Department, Persahabatan Government Hospital, Jakarta, Indonesia |
Tyrosine kinase inhibitors (TKIs; e.g., erlotinib, gefitinib, and afatinib) are the first-line therapy for non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) (+) common mutation. The study’s objective was to analyze the cost-effectiveness of erlotinib, gefitinib, and afatinib in NSCLC patients. The subjects of the study were NSCLC patients with EGFR (+) mutation receiving either erlotinib, gefitinib, or afatinib from January 2017 to December 2019. The exclusion criteria were patients receiving the respective therapy for less than 2 months and patients unable to complete the treatment until after December 2019. The parameter of treatment effectiveness was progression-free survival (PFS), which was measured as the time from initiation of the therapy until disease progression occurred or a patient became deceased. Direct medical costs, from the hospital perspective, were calculated during the treatment. A nonparametric Kruskal-Wallis test was conducted to compare the median PFS and direct medical cost between the three treatment groups. The median PFS of patients receiving erlotinib, gefitinib, and afatinib was 8 months, 12 months, and 5 months, respectively. There were significant differences in the monthly direct medical costs between the study groups: erlotinib (IDR 13,545,116), gefitinib (IDR 14,727,887), and afatinib (IDR 12,146,834). The cost-effectiveness ratio of the study groups was as follows: erlotinib IDR 1,693,139.50/months; gefitinib IDR 1,227,323.92/months; and afatinib IDR 2,429,366.80/months. Gefitinib was the most cost-effective TKI, followed by erlotinib and afatinib. © 2021. Fitri Nurhayati et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). All rights reserved. |
afatinib; Cost-effectiveness; erlotinib; gefitinib; non-smallcell lung cancer. |
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Open Science Publishers LLP Inc. |
22313354 |
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