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247 |
Isa M.M., Thayeb A., Meildi M., Hutagalung M.B.Z. |
57218775163;57219243978;57226686555;57210153230; |
Complete tubular duplication of colon presenting as rectovestibular fistula: A case report |
2021 |
Bali Medical Journal |
10 |
2 |
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526 |
528 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112379837&doi=10.15562%2fbmj.v10i2.2386&partnerID=40&md5=d43bedd4e25f7ac4c1c60fafddc9df64 |
Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Syiah Kuala/Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Syiah Kuala/Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia |
Isa, M.M., Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Syiah Kuala/Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Thayeb, A., Pediatric Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Meildi, M., Department of Surgery, Faculty of Medicine, Universitas Syiah Kuala/Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia; Hutagalung, M.B.Z., Department of Surgery, Faculty of Medicine, Universitas Syiah Kuala/Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia |
Background: Duplication of the gastrointestinal tract is a rare congenital disorder in pediatric patients. Complete resection in case of a total tubular duplication that requires total or subtotal colectomy is undesirable in children. Case Presentation: This case presented a simple surgical technique for treating complete colonic duplication without colonic resection. A 2 months old female baby with abdominal distention and stool complaint came out from her vaginal vestibular and normal anus. A digital rectal exam showed a palpable mass in the posterior region. Abdominal CT Scan showed a rounded mass with size 2x2 cm in the left posterolateral of rectum region. The initial diagnosis was suspected sacrococcygeal tumor type 4 with rectovestibular fistula. Intraoperative findings showed duplication of the caecum, appendix, total colon (ascending to sigmoid) and rectum (one directed to the vagina and the other to anus). The ileostomy was done 20 cm from the ileocaecal junction as a temporary treatment to relieving distention with definitive repair planned in the following months. The second stage repair was performed after 1-year-old with posterosagital anorectoplasty followed by distal separation of the duplicated colon using a 12 cm linear stapler. For this case, the third stage repair was done one year after the previous surgery to close the remaining ileostomy. The patient’s outcome showed good results with normal defecating function and no complication. Conclusion: Complete tubular duplication is a rare case without specific clinical symptoms, but the assessment of the diagnosis can be assisted by radiology such as abdominal CT and barium enema. We hope this article could illustrate management for complete tubular duplication of colon presenting as rectovestibular fistula, thus reflect how important clinical judgment and initial diagnostic in our health care system. © 2021, Sanglah General Hospital. All rights reserved. |
Colon Duplication; Repair; Surgery |
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Sanglah General Hospital |
20891180 |
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Article |
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428 |
Soetisna T.W. |
57214887740; |
A new hope of cd133+ bone marrow stem cell for functional exercise capacity improvement in low ejection fraction coronary artery bypass graft patients: A clinical trial |
2021 |
Bali Medical Journal |
10 |
1 |
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229 |
233 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106002523&doi=10.15562%2fbmj.v10i1.2255&partnerID=40&md5=80046a217774aa6ef82836d9a524c4ff |
Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Soetisna, T.W., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Patients with low ejection fraction who are undergoing coronary artery bypass graft (CABG) only have an insignificant improvement in ejection fraction. This condition will make a little hope to achieve an improvement in physical performance. But now, from a view study, CD133+ stem cells offer new hope for this situation. This study evaluates CD133+ bone marrow stem cells’ role for functional exercise capacity improvement in low ejection fraction coronary artery bypass graft patients. Methods: Thirty patients with ischemic heart disease who had ejection fraction<35% at the National Cardiovascular Center were randomized into 2 groups. The treatment group undergoes the CABG + CD133+ procedure and the control group undergoes the CABG only. All research subjects underwent follow-up before and 6 months after the procedure. Fraction ejection, scar size, wall motion score index, ventricular dimensions, myocardial perfusion measured by cardiac MRI, 6 Minutes Walking Test (6MWT) and Minnesota Living with Heart Failure Questionnaire (MLHFQ) as an additional parameter for physical performance and quality of life. Data was analyzed using SPSS version 21 for Windows. Results: The results of the fraction ejection parameters showed a significant improvement in the treatment group, from 25.88±5.66% to 34.57%±11.31% compared to CABG only 30.18±3.85% to 31.61±7.89% (p=0.040), in the perfusion defect showed improvement but not significant, left ventricular end-systolic volume and left ventricular end-diastolic volume showed improvement with no significant result, scar size was found to be an improvement in the treatment group 10 persons (76.92%) compared to the control group 5 persons (38, 46%) (p=0.040), the wall motion score index and 6MWT showed a significant improvement in the treatment group (p=0.003 and p=0.03, respectively). The MLHFQ parameter showed improvement but not significant. Conclusion: CD 133+ stem cell implantation in patients with low ejection fraction who undergo CABG provides improved myocardial function and indirectly improves functional exercise capacity and patients’ quality of life. © 2021, Sanglah General Hospital. All rights reserved. |
CABG; CD133+ Stem cell; Functional exercise capacity |
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Sanglah General Hospital |
20891180 |
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Article |
#N/A |
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451 |
Christian, Puruhita N., Himawan A., Muis S.F., Fasitasari M., Pangarsa E.A., Panigoro S.S., Sutandyo N. |
57224896360;57224902090;57224910728;57193264578;57192872474;57204907532;56790104300;26028099200; |
Fat intake in Javanese breast cancer patients: Any difference? |
2021 |
Bali Medical Journal |
10 |
1 |
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320 |
324 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108565233&doi=10.15562%2fbmj.v10i1.2173&partnerID=40&md5=7840397cf684896b0d8d5929cbb1e87c |
Resident of Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Clinical Nutrition Department, SMC Telogorejo Hospital, Semarang, Indonesia; Faculty of Medicine, Universitas Islam Sultan Agung-Sultan Agung Islamic Hospital Semarang, Indonesia; Hematology-Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Oncology Surgery Division, Surgery Department, Faculty of Medicine, Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Hematology-Oncology Division, Internal Medicine Department, Dharmais National Cancer Centre Hospital, Jakarta, Indonesia |
Christian, Resident of Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Puruhita, N., Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia, Clinical Nutrition Department, SMC Telogorejo Hospital, Semarang, Indonesia; Himawan, A., Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia, Clinical Nutrition Department, SMC Telogorejo Hospital, Semarang, Indonesia; Muis, S.F., Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Fasitasari, M., Clinical Nutrition Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia, Faculty of Medicine, Universitas Islam Sultan Agung-Sultan Agung Islamic Hospital Semarang, Indonesia; Pangarsa, E.A., Hematology-Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Diponegoro, Dr. Kariadi Hospital, Semarang, Indonesia; Panigoro, S.S., Oncology Surgery Division, Surgery Department, Faculty of Medicine, Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Sutandyo, N., Hematology-Oncology Division, Internal Medicine Department, Dharmais National Cancer Centre Hospital, Jakarta, Indonesia |
Background: Breast cancer is the second most prevalent women’s malignancy in Central Java. The risk of breast cancer incidence drops by 2.5 times for breast cancer if fat consumption is reduced by 50%, although not all types of fat intake increase the risk of breast cancer incidence. Fat consumption in Indonesia increased by 11% in the last 7 years. The study aims to analyze the differences in fat intake between breast cancer subjects and healthy subjects. Methods: This study is a cross-sectional study. We invited 45 outpatients diagnosed with breast cancer in Kariadi Hospital from January to August 2019 as well as 45 healthy subjects who are relatives or friends of the patients who met the inclusion criteria to participate in this study. Various types of fat intake were measured with quantitative food frequency questionnaires. The statistical analysis employed a chi-square test and Mann-Whitney test for non-parametric tests and an independent t-test for parametric data. Results: There was a significant difference in polyunsaturated fatty acid (PUFA) intake between breast cancer patients and healthy subjects (p=0.022). This study found no significant differences in total fat intake (p=0.677), saturated fatty acid (SFA) (p=0.368), monounsaturated fatty acid (MUFA) (p=0.593), omega 3 (p=0.095), omega 6 (p=0.092), and TFA (p=0.669) between breast cancer patients and healthy subjects. Conclusion: There is a significant difference in PUFA intake, but not in the other types of fat between breast cancer patients and healthy subjects. For further study, more precise and objective fat intake measurements may be achieved in studies with animal models. © 2021, Sanglah General Hospital. All rights reserved. |
Breast cancer; Fat; Intake; Nutrition |
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Sanglah General Hospital |
20891180 |
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Article |
#N/A |
#N/A |
#N/A |
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723 |
Rohsiswatmo R., Widodo A.D., Munasir Z., Medise B.E. |
55533574600;57117722400;7801694370;57226215370; |
Prebiotic supplementation supports immunity & growth-development in preterm infants: A review and expert perspectives |
2021 |
Bali Medical Journal |
10 |
2 |
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785 |
792 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114340415&doi=10.15562%2fbmj.v10i2.2490&partnerID=40&md5=cffe54e9756788dc9eeb8ca22d1e3c5a |
Department of Child Health, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Harapan Kita National Center for Woman and Child Health Care, Jakarta, Indonesia |
Rohsiswatmo, R., Department of Child Health, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Widodo, A.D., Harapan Kita National Center for Woman and Child Health Care, Jakarta, Indonesia; Munasir, Z., Department of Child Health, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Medise, B.E., Department of Child Health, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Preterm birth still causes significant mortality and morbidity in newborns, despite modern advancements in preterm care. The gut microbiota is the most significant microbial colonization in the human body and plays a significant role in supporting a healthy body. Preterm infants are susceptible to gut dysbiosis, which is thought to contribute to the many adverse outcomes of prematurity, such as necrotizing enterocolitis (NEC), late-onset sepsis (LOS), and developmental delays. Human breast milk is considered the ideal nutrition source for newborns and can help create ideal microbiota in preterm infants. Breast milk contains human milk oligosaccharides (HMO), prebiotics that promote beneficial bacteria growth, absent in cow’s milk. Supplementation of non-milk oligosaccharides such as long-chain fructo-oligosaccharides (lcFOS) and small-chain galacto-oligosaccharides (scGOS) in formula milk for preterm infants is found to be beneficial with a favourable safety profile. This review discusses gut microbiota in preterm neonates, its role in developing immune systems, growth and development, and the benefits of prebiotic supplementation. © 2021, Sanglah General Hospital. All rights reserved. |
Development; Growth; Immunity; Prebiotic; Prematurity; Preterm birth |
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Sanglah General Hospital |
20891180 |
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Review |
#N/A |
#N/A |
#N/A |
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825 |
Wardoyo S., Pardede J.P.P., Asari H.A. |
57211106608;57222900416;57222898312; |
Patients’ characteristics following reoperation after modified blalock-taussig shunt (Mbts) in cardiac centre national general hospital cipto mangunkusumo from 2018-2020 |
2021 |
Bali Medical Journal |
10 |
1 |
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103 |
107 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104181375&doi=10.15562%2fbmj.v10i1.2124&partnerID=40&md5=71f0e48c1ff1cce6ec58341517f2fb6a |
Thoracic, Cardiac, and Vascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Wardoyo, S., Thoracic, Cardiac, and Vascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pardede, J.P.P., Thoracic, Cardiac, and Vascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Asari, H.A., Thoracic, Cardiac, and Vascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Background: Modified Blalock-Taussig shunt (MBTS) is a common palliative procedure for congenital heart defect to connect the systemic to the pulmonary circulation via a synthetic shunt from a subclavian artery to a pulmonary artery. However, certain postoperative complications do exist, such as blockage. Early identification of modifiable risk factors is important to prompt early intervention for better outcomes. Material: This article is a descriptive narrative retrospective study. We gather data from the Cipto Mangunkusumo Hospital Cardiovascular Center medical report of 8 patients having undergone reoperation post-MBTS surgery as their first operation between January 2018 and October 2020. Data were analyzed using SPSS version 20 for Windows. Results: The patient’s age ranged from 3 months to 30 years old. Seven of them suffered from shunt occlusion complications, while the other suffered from the bleeding problem. The laboratory results showed that preoperative hemoglobin (18.9±4.1 g/dL vs. 16.90 (10.80-19.20) g/dL), hematocrit (58.8±12.40% vs. 42.9±14.30%), platelet counts (284.487±147.003 vs. 210.625±104.688) 103/uL, and oxygen saturation (86.00 (75.00-89.00) vs. 70.00±17.00) levels were higher than the pre-reoperative. The coagulation markers showed that PT value has increasing trend (1.10 (0.90-2.30) vs. 1.30±0.20) while aPTT (5.90 (2.90-6.30) vs. 2.30 (1.60-5.30)) seconds and activated clotting time (ACT) (205.00±86.00 vs. 165.00 (114.00-255.00)) showed the opposite. Conclusion: MBTS remains the first-choice bridging palliation surgery to increase the pulmonary blood flow in congenital heart defects. The cause of shunt failure remains inconclusive in this study. Other studies suggest that graft material choice, S/PA ratio, S/W ratio, operative approach, thrombus formation, and aPTT value contribute to shunt failure, thus needing a reoperation. © 2021, Sanglah General Hospital. All rights reserved. |
Characteristic; Modified Blalock-Taussig Shunt; Re-operation |
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Sanglah General Hospital |
20891180 |
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Article |
#N/A |
#N/A |
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No records
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776 |
Liem I.K., Oktavina R., Zakiyah, Anggraini D., Deraya I.E., Kodariah R., Krisnuhoni E., Wuyung P.E. |
55802927800;57224993301;57224999441;57225000673;57216313121;14010667100;35310982200;57192889605; |
Intravenous injection of umbilical cord-derived mesenchymal stem cells improved regeneration of rat liver after 2aaf/ccl4-induced injury |
2021 |
OnLine Journal of Biological Sciences |
21 |
2 |
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317 |
326 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108885347&doi=10.3844%2fojbsci.2021.317.326&partnerID=40&md5=e4defc3d20063b1647d2241805bc3694 |
Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell and Tissue Engineering Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine and Health Science, Universitas Kristen Krida Wacana, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Yarsi, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Animal Research Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Liem, I.K., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktavina, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine and Health Science, Universitas Kristen Krida Wacana, Jakarta, Indonesia; Zakiyah, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Universitas Yarsi, Jakarta, Indonesia; Anggraini, D., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Deraya, I.E., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kodariah, R., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Krisnuhoni, E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wuyung, P.E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Animal Research Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
The effectivity of Mesenchymal Stem Cell (MSC) therapy for chronic liver injury is still questioned due to its possibility to have a pro-fibrotic effects. Other consideration is the preferably peripheral Intravenous (IV) route of application rather than direct to the target organ, such as portal vein or splenic vein, since the most of MSC will be trapped in the lung and other organs. Therefore, a study has been carried out in an animal model of chronic liver injury, 2AAF/CCl4 rats, to find out whether IV injection of single dose, 1×106 human umbilical cord-derived MSC (hUC-MSC) can regenerate the liver tissue and reduce the fibrosis. Male Wistar rats (n = 18, 8 weeks, 160-200 g) were divided into three groups of six rats, i.e., group I (control/healthy rats), group II (2AAF/CCl4-induced liver injury with hUC-MSC injected rats) and group III (2AAF/CCl4-incuded liver injury without hUC-MSC injected rats). Gross anatomical features of the livers and blood examination were tested. There was no significant different of the Alanine Aminotransferase (ALT) and Albumin serum level between groups; however there was a tendency of ALT decrease and Albumin increase in stem cells treated rats (group II). Histopathological observation using hematoxylin eosin and Masson’s trichrome staining showed an improvement in the liver damage condition (reduction of necrosis and coverage area of fat degeneration) and an improvement in the fibrosis condition in the group II compared to the group III. None of group II rat had fallen into cirrhosis as seen in group III. Immunohistochemistry staining against Caspase 3 (biomarker for apoptosis) also showed significant reduction (p = 0.038; Tukey multiple comparison test) of group II expression index (2.74%) compared to the group III (8.64%). In conclusion, IV injection of single dose, 1×106 hUC-MSC could regenerate the liver tissue and reduce the fibrosis in 2AAF/CCl4 rats model of chronic liver injury. © 2021 Isabella Kurnia Liem, Reni Oktavina, Zakiyah, Dian Anggraini, Irwina Eka Deraya, Ria Kodariah, Ening Krisnuhoni, and Puspita Eka Wuyung. |
2AAF/CCl4; Caspase 3; Liver Fibrosis; Liver Injury; Liver Regeneration; MSC |
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Science Publications |
16084217 |
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Article |
Q4 |
152 |
23000 |
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786 |
Sahar N., Birowo P., Thuffi R., Muharram A.R., Ode Z.W., Subahar R., Yazid F., Handayani S.I., Prasasty V.D. |
57212464367;6504153311;57212475033;57224640920;57222324817;57224626083;57207890516;57207819540;56019989700; |
Fsh receptor and ki-67 protein expressions of endometrial macaque in mid-luteal phase after exposure to various doses of recombinant fsh and fixed-dose of gnrh agonist |
2021 |
OnLine Journal of Biological Sciences |
21 |
2 |
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260 |
266 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108083891&doi=10.3844%2fojbsci.2021.260.266&partnerID=40&md5=6752f9329d0eda8fbfaee279007348a8 |
Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departemen of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia |
Sahar, N., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Birowo, P., Departement of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Thuffi, R., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muharram, A.R., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ode, Z.W., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Subahar, R., Departemen of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yazid, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Handayani, S.I., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prasasty, V.D., Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia |
There are many advances in Assisted Reproductive Technologies (ARTs). However, implantation rates are still low. The embryo implantation is a mutual interaction between the blastocyst and endometrium. This study aimed to investigate the endometrial cell proliferation stimulated by recombinant Follicle-Stimulating Hormone (rFSH) in various doses by looking at FSH-Receptor (FSHR) and Ki-67 protein expressions. The studied samples were Stored Biological Materials (SBMs) from the endometrial tissue of Macaca nemestrina. All sample was obtained from fifteen macaques, divided into four groups, which three groups were treated with rFSH and given fixed-dose (160 µg/day) of Gonadotropin-Releasing Hormone (GnRH) agonists and one control group as normal group. The three treated macaque groups were stimulated with 30, 50 and 70 IU doses of rFSH. There was no significant difference in various doses of rFSH towards FSHR and Ki-67 expressions in endometrial tissue of M. nemestrina. Therefore, this result did not significantly correlate FSHR and Ki-67 expressions in the endometrial tissue of M. nemestrina after rFSH administration. Moreover, the highest rFSH dose did not reduce the FSHR and Ki-67 expressions and there was no correlation between FSHR and Ki-67 expressions. It can be concluded that macaque endometrial cells were receptive to the given dosages of rFSH. © 2021 Nurhuda Sahar, Ponco Birowo, Rosalina Thuffi andhea Raden Muharram, Zulhulaifah Wa Ode, Rijal Subahar, Fatmawaty Yazid, Supri Irianti Handayani and Vivitri Dewi Prasasty. |
Endometrial Tissue; FSHR; Macaque; Proliferation Marker; RFSH |
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Science Publications |
16084217 |
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Article |
Q4 |
152 |
23000 |
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864 |
Indriyani, Liem I.K., Wuyung P.E., Adnindya M.R., Nasution A.A., Wardiansah, Jusuf A.A. |
57195988823;55802927800;57192889605;57195990858;57195984460;57222188547;57192275719; |
The dynamic of afamin and alpha-fetoprotein expression during rat liver development |
2021 |
OnLine Journal of Biological Sciences |
21 |
1 |
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26 |
32 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101833482&doi=10.3844%2fojbsci.2021.26.32&partnerID=40&md5=63694adea4e7ba46c95652e49c319ed0 |
Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Muhammadiyah Palembang, Palembang, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Indonesia; Departement of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia; Department of Anatomy, Faculty of Medicine and Health Science, Universitas Bengkulu, Bengkulu, Indonesia; Departement of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Indriyani, Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Universitas Muhammadiyah Palembang, Palembang, Indonesia; Liem, I.K., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Indonesia; Wuyung, P.E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Departement of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Adnindya, M.R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia; Nasution, A.A., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine and Health Science, Universitas Bengkulu, Bengkulu, Indonesia; Wardiansah, Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Sriwijaya University, Palembang, Indonesia; Jusuf, A.A., Departement of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Liver has a high level of Alpha-fetoprotein which is assumed to be important for mammalian development. However, Alpha-fetoprotein knockout studies in mice suggested that despite the absence of Alpha-fetoprotein, mice developed normally; the only abnormality observed was infertility in female mice. There are indications that Afamin, a protein that has a gene sequence located on the same chromosome as Alpha-fetoprotein, may compensate for the absence of Alpha-fetoprotein during embryonic development. Nevertheless, research on the dynamics of Afamin expression and its correlation with Alpha-fetoprotein has not been reported. Therefore, it has been done a baseline study to determine the pattern and distribution of Alpha-fetoprotein expression and its correlation with Afamin expression in the developing rat liver. An analytic observational study was performed to study the expression of Afamin and Alpha-fetoprotein in the rat embryos (embryonic day/ED12.5, ED14.5, ED16.5, ED18.5), neonates and adults using an immunohistochemistry technique by assessing the location and intensity of expression using the Immunohistochemistry Optical density score. Afamin started to express in ED18.5 and was evenly distributed in the hepatocytes and was maintained until adulthood. Whereas, Alpha-fetoprotein has been seen at ED12.5 and was distributed evenly in the hepatoblast. At ED18.5, Alpha-fetoprotein expression reached a peak and decreased dramatically after birth. Spearman correlation test showed that both proteins' expressions were correlated in the opposite direction (P<0.05 and r =-0.695). In conclusion, Afamin and Alpha-fetoprotein have an opposite expression during development. The time point of intersection was ED18.5; implying the peak of hepatoblast proliferation to enter the differentiation process. © 2021 Indriyani, Isabella Kurnia Liem, Puspita Eka Wuyung, Msy Rulan Adnindya, Ahmad Azmi Nasution, Wardiansah and Ahmad Aulia Jusuf. |
Afamin; Alpha-Fetoprotein; Hepatoblast; Hepatocytes; Liver Development |
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Science Publications |
16084217 |
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Article |
Q4 |
152 |
23000 |
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18 |
Firdaus R., Theresia S., Austin R., Tiara R. |
57423039300;57222095380;57422434500;57422587800; |
Propofol effects in rodent models of traumatic brain injury: A systematic review |
2021 |
Asian Biomedicine |
15 |
6 |
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253 |
265 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123275403&doi=10.2478%2fabm-2021-0032&partnerID=40&md5=fdc2eb2da5eaacf73d60546fd4a9fc72 |
Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Firdaus, R., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Theresia, S., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Austin, R., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Tiara, R., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Background: Traumatic brain injury (TBI) causes high mortality and disability worldwide. Animal models have been developed to explore the complex processes in TBI. Propofol is used to manage head injuries during surgical intervention and mechanical ventilation in patients with TBI. Many studies have investigated the neuroprotective effect of propofol on TBI. However, other studies have shown neurotoxic effects. Objectives: To review systematically the literature regarding the neuroprotective and neurotoxic effects of propofol in rodent models of TBI. Methods: Data from rodents as models of TBI with propofol as one of the intervention agents, and/or comparing the neuroprotective effects of propofol with the other substances in rodent models of TBI, were obtained from PubMed, EBSCO Host, and ProQuest databases. The PRISMA 2020 statement recommendations were followed and research questions were developed based on PICOS guidelines. Data was extracted from the literature using a standardized Cochrane method. Results: We analyzed data from 12 articles on physiological changes of experimental animals before and after trauma, the effects of propofol administration, and the observed neurotoxic effects. The effects of propofol administration were observed in terms of changes in traumatic lesion volume, the release of antioxidants and inflammatory factors, and the neurological function of rodent models of TBI. Conclusion: Propofol has neuroprotective and neurotoxic effects via several mechanisms, and various doses have been used in research to determine its effects. The timing of administration, the dose administered, and the duration of administration contribute to determine the effect of propofol in rodent models of TBI. However, the doses that produce neuroprotective and neurotoxic effects are not yet clear and further research is needed to determine them. © 2021 Riyadh Firdaus et al., published by Sciendo. |
anesthetics; brain injuries, traumatic; neuroprotection; propofol; Rodentia |
calpain; carbon dioxide; catalase; citicoline; diazepam; erythropoietin; fentanyl; glucose; immunoglobulin enhancer binding protein; interleukin 1beta; interleukin 6; isoflurane; ketamine; malonaldehyde; mitogen activated protein kinase p38; morphine; nitric oxide; oxygen; pentobarbital; propofol; semaphorin; superoxide dismutase; tumor necrosis factor; xanthine oxidase; adult; antiinflammatory activity; antioxidant activity; arterial carbon dioxide tension; arterial oxygen tension; blood pH; brain edema; brain injury; Cochrane Library; combination drug therapy; controlled study; core temperature; diffuse brain injury; dose response; drug megadose; female; glucose blood level; head injury; heart rate; hematocrit; lesion volume; lipid peroxidation; low drug dose; male; mean arterial pressur |
Sciendo |
19057415 |
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Review |
Q4 |
178 |
20816 |
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204 |
Heltty H., Sitorus R., Martha E., Nusdwinuringtyas N. |
57262112500;57194329674;55841280100;56608215500; |
Experience of the patient's success in facing post-stroke urinary incontinence: The patient's perspective |
2021 |
Frontiers of Nursing |
8 |
3 |
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291 |
301 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115061619&doi=10.2478%2ffon-2021-0030&partnerID=40&md5=9c066e6d2b1fc65cd5adc1fc8034247d |
Faculty of Nursing, Medical Surgical, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Faculty of Public Health, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Faculty of Medicine, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia |
Heltty, H., Faculty of Nursing, Medical Surgical, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Sitorus, R., Faculty of Nursing, Medical Surgical, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Martha, E., Faculty of Public Health, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia; Nusdwinuringtyas, N., Faculty of Medicine, University of Indonesia, Jawa Barat, Depok, 16424, Indonesia |
Objective: Post-stroke urinary incontinence (UI) is one of the sequelae of stroke. This situation affects all aspects of the patient's life - physically, psychologically, socially, and spiritually. This study aimed to investigate the experience of patients' success in facing a post-stroke UI. Methods: A qualitative study using the Rapid Assessment Procedure (RAP) approach was used in this study. Informants were selected using purposive sampling. In-depth interviews with as many as 8 patients who had recovered from post-stroke UI and living in the greater area of Southeast Sulawesi (Indonesia) were conducted. In-depth interviews were also conducted with 8 caregivers and 2 nurses. Data were analyzed using a thematic analysis approach and interpretation of data was based on Humanbecoming theory and Self-care deficit theory of nursing. Results: Five successful things the patients experienced during post-stroke UI were identified. The five successes were as follows: they provided information to get to know and understand post-stroke UI, followed the procedures to overcome post-stroke UI, conducted self-control exercises and stayed motivated, performed daily activities independently according to ability, and made use of family support and peers' attention. Conclusions: These findings indicated that persistence, belief, independence, and social support (family and peer) made patients to successfully face their post-stroke UI and improved their quality of life. These findings also became the basis for developing a post-stroke UI management model based on Humanbecoming theory and Self-care deficit theory of nursing. © 2021 Heltty Heltty et al., published by Sciendo. |
experience of patient's success; patient's perspective; post-stroke urinary incontinence |
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Sciendo |
25448994 |
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Review |
Q4 |
152 |
22962 |
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