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Riset dan Pengabdian Masyarakat Do Research Sosial Service and Innovation

Id	Authors	Author S Id	Title	Year	Source Title	Volume	Issue	Art No	Page Start	Page End	Cited By	Link	Affiliations	Authors With Affiliations	Abstract	Author Keywords	Index Keywords	Publisher	Issn	Pubmed Id	Document Type	Sjr Best Quartile	Sjr	Sjr Rank
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467	Miftahussurur M., Doohan D., Syam A.F., Nusi I.A., Subsomwong P., Waskito L.A., Maulahela H., Akil F., Uwan W.B., Siregar G., Fauzia K.A., Rezkitha Y.A.A., Rahman A., Wibawa I.D.N., Saudale A.M.J., Richardo M., Sugihartono T., Chomariyati A., Bramantoro T., Uchida T., Yamaoka Y.	56323903000;57204644036;8443384400;56543515200;57113712700;57192177367;57189612709;35191671700;57093988500;56483277100;57204649404;56543533600;57212819255;6504449940;57192179505;57207621686;57194156387;57222871823;57196010143;35286123100;55183784100;	Cyp2c19 polymorphisms in indonesia: Comparison among ethnicities and the association with clinical outcomes	2021	Biology	10	4	300				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104101307&doi=10.3390%2fbiology10040300&partnerID=40&md5=5c1d7696c67d83bbcf546211d5004bf0	Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia; Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia; Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Aomori, Hirosaki, 036-8562, Japan; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Center of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Department of Internal Medicine, Santo Antonius Hospital, Pontianak, 78243, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatra Utara, Medan, 20155, Indonesia; Faculty of Medicine, University of Muhammadiyah Surabaya, Surabaya, 60113, Indonesia; Department of Internal Medicine, Kolaka General Hospital, Kolaka, 93511, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Udayana, Denpasar, 80232, Indonesia; Department of Internal Medicine, Prof. Dr. W. Z. Johannes General Hospital, Kupang, 85111, Indonesia; Department of Internal Medicine, Merauke City General Hospital, Merauke, 99613, Indonesia; Department of Dental Public Health, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, 60131, Indonesia; Department of Molecular Pathology, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Global Oita Medical Advanced Research Center for Health, Oita University, Yufu, 879-5593, Japan; Department of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, TX 77030, United States	Miftahussurur, M., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia, Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia; Doohan, D., Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Syam, A.F., Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Aomori, Hirosaki, 036-8562, Japan; Nusi, I.A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia; Subsomwong, P., Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan, Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine, Aomori, Hirosaki, 036-8562, Japan; Waskito, L.A., Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Maulahela, H., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Akil, F., Center of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, 90245, Indonesia; Uwan, W.B., Department of Internal Medicine, Santo Antonius Hospital, Pontianak, 78243, Indonesia; Siregar, G., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatra Utara, Medan, 20155, Indonesia; Fauzia, K.A., Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Rezkitha, Y.A.A., Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia, Faculty of Medicine, University of Muhammadiyah Surabaya, Surabaya, 60113, Indonesia; Rahman, A., Department of Internal Medicine, Kolaka General Hospital, Kolaka, 93511, Indonesia; Wibawa, I.D.N., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Udayana, Denpasar, 80232, Indonesia; Saudale, A.M.J., Department of Internal Medicine, Prof. Dr. W. Z. Johannes General Hospital, Kupang, 85111, Indonesia; Richardo, M., Department of Internal Medicine, Merauke City General Hospital, Merauke, 99613, Indonesia; Sugihartono, T., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia; Chomariyati, A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia; Bramantoro, T., Department of Dental Public Health, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, 60131, Indonesia; Uchida, T., Department of Molecular Pathology, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Yamaoka, Y., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr, Soetomo Teaching Hospital, Universitas Airlangga, Surabaya, 60286, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan, Global Oita Medical Advanced Research Center for Health, Oita University, Yufu, 879-5593, Japan, Department of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, TX 77030, United States	CYP2C19 polymorphisms are important factors for proton pump inhibitor-based therapy. We examined the CYP2C19 genotypes and analyzed the distribution among ethnicities and clinical outcomes in Indonesia. We employed the polymerase chain reaction-restriction fragment length polymorphism method to determine the CYP2C19 genotypes and evaluated inflammation severity with the updated Sydney system. For CYP2C192, 46.4% were the homozygous wild-type allele, 14.5% were the homozygous mutated allele, and 39.2% were the heterozygous allele. For CYP2C193, 88.6% were the homozygous wild-type allele, 2.4% were the homozygous mutated allele, and 9.0% were the heterozygous allele. Overall, the prevalence of rapid, intermediate, and poor metabolizers in Indonesia was 38.5, 41.6, and 19.9%, respectively. In the poor metabolizer group, the frequency of allele 2 (78.8%) was higher than the frequency of allele 3 (21.2%). The Papuan had a significantly higher likelihood of possessing poor metabolizers than the Balinese (OR 11.0; P = 0.002). The prevalence of poor metabolizers was lower compared with the rapid and intermediate metabolizers among patients with gastritis and gastroesophageal reflux disease. Intermediate metabolizers had the highest prevalence, followed by rapid metabolizers and poor metabolizers. Dosage adjustment should therefore be considered when administering proton pump inhibitor-based therapy in Indonesia. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.	CYP2C19; Gastritis; H. pylori; Infectious disease; Polymorphism		MDPI AG	20797737		Article	Q1	1731	1747	View
470	Takhwifa F., Aninditha T., Setiawan H., Sauriasari R.	57222711645;57189611205;55292870100;16246507200;	The potential of metformin as an antineoplastic in brain tumors: A systematic review	2021	Heliyon	7	4	e06558			3	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103788211&doi=10.1016%2fj.heliyon.2021.e06558&partnerID=40&md5=ec9287d374f7d13b7c0752898249a4ba	Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Takhwifa, F., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia; Aninditha, T., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiawan, H., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia; Sauriasari, R., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia	Brain tumors are challenging to handle and cause severe mortality and morbidity. The primary therapy for brain tumors, a combination of radiotherapy, chemotherapy (i.e temozolomide), and corticosteroids, is considered inadequate to improve patients' clinical conditions and associated with many adverse effects. There is an urgent need for new compounds or repurposing of existing therapies, which could improve brain tumor patients' prognosis. Metformin, commonly used for type 2 diabetes medication, has been examined for its protective action in cancer, reducing cancer risk and cancer-related mortality. However, its effect on cancer is still in rigorous debate. This study examines recent studies on the effects of metformin in primary brain tumor patients through systematic reviews. The literature search was performed on PubMed, ScienceDirect, and SpringerLink databases for articles published between 2013 and 2020. We selected clinical studies comparing the therapeutic outcomes of brain tumor therapy with and without metformin. The clinical benefits of the drug were assessed through the overall survival (OS) and progression-free survival (PFS) of brain tumor patients. Those studies demonstrated that the combination of metformin with temozolomide given post-radiotherapy resulted in better OS and PFS. Nonetheless, the efficacy and safety of metformin need further clinical testing in the wider population. © 2021 The Authors	Antidiabetic; Antineoplastic; Metformin; Primary brain tumor; Survival		Elsevier Ltd	24058440		Review	Q1	455	10919	View
471	Sampurna M.T.A., Rohsiswatmo R., Primadi A., Wandita S., Sulistijono E., Bos A.F., Sauer P.J.J., Hulzebos C.V., Dijk P.H.	57201733407;55533574600;8422152900;57194904658;57218101844;36839156800;57191375642;6603928053;6701798049;	The knowledge of Indonesian pediatric residents on hyperbilirubinemia management	2021	Heliyon	7	4	e06661				https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103706107&doi=10.1016%2fj.heliyon.2021.e06661&partnerID=40&md5=fe30c346677666133417d4195cc4b825	Neonatology Division, Department of Pediatrics, Airlangga University Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Neonatology Division, Department of Pediatrics, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatrics, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Neonatology Division, Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Pediatrics, Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands	Sampurna, M.T.A., Neonatology Division, Department of Pediatrics, Airlangga University Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Rohsiswatmo, R., Neonatology Division, Department of Pediatrics, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Primadi, A., Department of Pediatrics, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Wandita, S., Neonatology Division, Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Sulistijono, E., Department of Pediatrics, Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Bos, A.F., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Sauer, P.J.J., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Hulzebos, C.V., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Dijk, P.H., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands	Hyperbilirubinemia in the newborn occurs more frequently in Indonesia. Therefore, it is important that pediatric residents in Indonesia acquire adequate knowledge of hyperbilirubinemia management. This study aims to determine the pediatric residents' knowledge on hyperbilirubinemia management, whether they follow recommended guidelines, and whether differences exist between five large Indonesian teaching hospitals. We handed out a 25-question questionnaire on hyperbilirubinemia management to pediatric residents at five teaching hospitals. A total of 250 questionnaires were filled in completely, ranging from 14 to 113 respondents per hospital. Approximately 76% of the respondents used the Kramer score to recognize neonatal jaundice. Twenty-four percent correctly plotted the total serum bilirubin levels (TSB) on the phototherapy (PT) nomograms provided by the American Academy of Pediatrics (AAP) and the National Institute for Health and Care Excellence (NICE) for full-term and nearly full-term infants. Regarding preterm infants <35 weeks' gestational age, 66% of the respondents plotted TSB levels on the AAP nomogram, although this nomogram doesn't apply to this category of infants. Seventy percent of residents knew when to perform an exchange transfusion whereas 27% used a fixed bilirubin cut-off value of 20 mg/dL. Besides PT, 25% reported using additional pharmaceutical treatments, included albumin, phenobarbitone, ursodeoxycholic acid and immunoglobulins, while 47% of the respondents used sunlight therapy, as alternative treatment. The limited knowledge of the pediatric residents could be one factor for the higher incidence of severe hyperbilirubinemia and its sequelae. The limited knowledge of the residents raises doubts about the knowledge of the supervisors and the training of the residents since pediatric residents receive training from their supervisors. © 2021 The Author(s)	Guidelines; Hyperbilirubinemia; Knowledge; Newborn infants; Residents		Elsevier Ltd	24058440		Article	Q1	455	10919	View
483	Sekarsari D., Amal M.Y., Napitupulu M.R., Wityaningsih Y.S.	57193342279;57221702104;57221696697;57221685402;	Annular pancreas mimicking hypertrophic pyloric stenosis in a female infant	2021	Radiology Case Reports	16	4		772	776		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099811331&doi=10.1016%2fj.radcr.2021.01.019&partnerID=40&md5=8fd0ab9e02d41a267af411f3964c26f2	Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia	Sekarsari, D., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Amal, M.Y., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Napitupulu, M.R., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Wityaningsih, Y.S., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia	Annular pancreas is a rare congenital intestinal obstruction to be found in infants. It is characterized by nonbilious vomiting, abdominal distention, and feeding intolerance that share similar symptoms with other intestinal obstructions. We reported a case of 11-month-old female infant with a history of nonbilious vomiting after coughing as much as 6 times per day 1 day before admission. The patient had an incorrect provisional diagnosis of hypertrophic pyloric stenosis based on ultrasound. Later on, an upper gastrointestinal series showed dilatation of the second part of the duodenum which was successfully treated by a duodenostomy during laparotomy procedure. It is suggested that treating an intestinal obstruction needs a further investigation when the symptoms were continuously repeated. © 2021	Annular pancreas; Congenital abnormality; Duodenostomy; Intestinal obstruction; Upper gastrointestinal series	hemoglobin; abdominal radiography; anemia; annular pancreas; Article; case report; chronic suppurative otitis media; clinical article; coughing; diagnostic error; diagnostic imaging; Down syndrome; duodenostomy; electrolyte disturbance; female; fever; hematocrit; human; human cell; hypertrophic pylorus stenosis; infant; intestine obstruction; laparotomy; laryngomalacia; nutritional status; obstructive airway disease; priority journal; ultrasound; vomiting	Elsevier Inc.	19300433		Article	Q4	221	18127	View
484	Sumantri S., Rengganis I., Laksmi P.W., Hidayat R., Koesnoe S., Shatri H.	6504606748;8449988000;8448343700;37067327300;26028015000;28767986500;	The impact of low muscle function on health-related quality of life in Indonesian women with systemic lupus erythematosus	2021	Lupus	30	4		680	686		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099752699&doi=10.1177%2f0961203320988595&partnerID=40&md5=98c96d7b7268512fcf94e7eabca204b8	Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Geriatric Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Rheumatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Psychosomatic Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia	Sumantri, S., Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia, Department of Internal Medicine, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Rengganis, I., Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Laksmi, P.W., Geriatric Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Hidayat, R., Rheumatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Koesnoe, S., Allergy and Clinical Immunology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Shatri, H., Psychosomatic Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia	Objective: There was no study aimed at evaluating the effect of muscle function on SLE patients' quality of life using the Sarcopenia Quality of Life (SarQoL) questionnaire. Methods: This cross-sectional study recruited 61 women with SLE consecutively, muscle function was measured with Jamar handheld-dynamometer and 6-meter walk test, HRQoL was measured with Sarcopenia Quality of Life (SarQoL) questionnaire. The cut-off point for low muscle strength (<18 kg) and low gait speed (<1.0 m/s) was according to the Asian Working Group on Sarcopenia 2019 criteria. Statistical analysis was conducted with a t-test for mean difference, and linear regression was used to adjust confounders (age, protein intake, physical exercise, and disease activity). Results: The subjects' mean muscle strength was 19.54 kg (6.94), and 44.3% (n = 27) was found to have low muscle strength. The subjects' mean gait speed was 0.77 m/s (0.20), and 90.3% (n = 55) was found to have low gait speed. The difference of total SarQoL score in subjects with normal and low muscle strength was found to be significant; 74.86 (9.48) vs. 65.49 (15.51) (p = 0.009), and still statistically significant after adjustments with age, protein intake, physical exercise level, and disease activity [B 0.56; 95% CI 0.08–1.03; p = 0.022]. The difference of total SarQoL score in subjects with normal and low physical performance was found to be not significant, 70.67 (11.08) vs. 70.72 (13.56) (p = 0.993). Conclusion: There was a significant difference in SarQoL's total score in normal compared with low muscle strength groups of Indonesian women with SLE. © The Author(s) 2021.	health-related quality of life; Muscle function; muscle strength; physical performance; SarQoL; systemic lupus erythematosus	corticosteroid; creatine kinase; prednisone; vitamin D; protein; adult; age; Article; corticosteroid therapy; creatine kinase blood level; cross-sectional study; disease activity; exercise; female; human; Indonesian; kidney function; low drug dose; lupus erythematosus nephritis; major clinical study; muscle function; muscle mass; muscle strength; pain severity; physical activity; physical performance; priority journal; protein intake; quality of life; quality of life assessment; Sarcopenia Quality of Life Questionnaire; six minute walk test; SLEDAI; systemic lupus erythematosus; vitamin blood level; walking speed; comparative study; epidemiology; immunology; Indonesia; muscle; pathophysiology; physiology; procedures; psychology; quality of life; questionnaire; sarcopenia; severity of illne	SAGE Publications Ltd	09612033	33470149	Article	Q2	1069	3961	View
487	Anacak Y., Zubizarreta E., Zaghloul M., Laskar S., Alert J., Gondhowiardjo S., Giselvania A., Correa-Villar R., Pedrosa F., Dorj B., Kamer S., Howard S.C., Quintana Y., Ribeiro R.C., Rosenblatt E., Hopkins K.	6603635579;6603081805;7005397003;26666792500;6603284454;6508327402;57217201891;57220085641;7004231496;57220089211;6508205483;7202813210;6603342439;7202534592;15767995600;7102810539;	The Practice of Paediatric Radiation Oncology in Low- and Middle-income Countries: Outcomes of an International Atomic Energy Agency Study	2021	Clinical Oncology	33	4		e211	e220	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096826569&doi=10.1016%2fj.clon.2020.11.004&partnerID=40&md5=2878f21b666e99aa706708e55c436b4a	Ege University School of Medicine, Izmir, Turkey; International Atomic Energy AgencyVienna, Austria; National Cancer Institute, Cairo University, Cairo, Egypt; Children's Cancer Hospital, Cairo, Egypt; Tata Memorial Hospital, Mumbai, India; Instituto de Oncología y Radiobiología, Habana, Cuba; Faculty of Medicine, University of Indonesia/Dr Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Centro Infantil Boldrini, Sao Paulo, Brazil; Instituto de Medicina Integral Prof. Fernando Figueira, Recife, Brazil; National Cancer Centre, Ulaanbaatar, Mongolia; University of Tennessee Health Science Center, Memphis, TN, United States; Harvard Medical School, Boston, MA, United States; St Jude Children's Research Hospital, Memphis, TN, United States	Anacak, Y., Ege University School of Medicine, Izmir, Turkey; Zubizarreta, E., International Atomic Energy AgencyVienna, Austria; Zaghloul, M., National Cancer Institute, Cairo University, Cairo, Egypt, Children's Cancer Hospital, Cairo, Egypt; Laskar, S., Tata Memorial Hospital, Mumbai, India; Alert, J., Instituto de Oncología y Radiobiología, Habana, Cuba; Gondhowiardjo, S., Faculty of Medicine, University of Indonesia/Dr Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Giselvania, A., Faculty of Medicine, University of Indonesia/Dr Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Correa-Villar, R., Centro Infantil Boldrini, Sao Paulo, Brazil; Pedrosa, F., Instituto de Medicina Integral Prof. Fernando Figueira, Recife, Brazil; Dorj, B., National Cancer Centre, Ulaanbaatar, Mongolia; Kamer, S., Ege University School of Medicine, Izmir, Turkey; Howard, S.C., University of Tennessee Health Science Center, Memphis, TN, United States; Quintana, Y., Harvard Medical School, Boston, MA, United States; Ribeiro, R.C., St Jude Children's Research Hospital, Memphis, TN, United States; Rosenblatt, E., International Atomic Energy AgencyVienna, Austria; Hopkins, K., International Atomic Energy AgencyVienna, Austria	Aims: Childhood cancer survival is suboptimal in most low- and middle-income countries (LMICs). Radiotherapy plays a significant role in the standard care of many patients. To assess the current status of paediatric radiotherapy, the International Atomic Energy Agency (IAEA) undertook a global survey and a review of practice in eight leading treatment centres in middle-income countries (MICs) under Coordinated Research Project E3.30.31; ‘Paediatric radiation oncology practice in low and middle income countries: a patterns-of-care study by the International Atomic Energy Agency.’ Materials and methods: A survey of paediatric radiotherapy practices was distributed to 189 centres worldwide. Eight leading radiotherapy centres in MICs treating a significant number of children were selected and developed a database of individual patients treated in their centres comprising 46 variables related to radiotherapy technique. Results: Data were received from 134 radiotherapy centres in 42 countries. The percentage of children treated with curative intent fell sequentially from high-income countries (HICs; 82%) to low-income countries (53%). Increasing deficiencies were identified in diagnostic imaging, radiation staff numbers, radiotherapy technology and supportive care. More than 92.3% of centres in HICs practice multidisciplinary tumour board decision making, whereas only 65.5% of centres in LMICs use this process. Clinical guidelines were used in most centres. Practice in the eight specialist centres in MICs approximated more closely to that in HICs, but only 52% of patients were treated according to national/international protocols whereas institution-based protocols were used in 41%. Conclusions: Quality levels in paediatric radiotherapy differ among countries but also between centres within countries. In many LMICs, resources are scarce, coordination with paediatric oncology is poor or non-existent and access to supportive care is limited. Multidisciplinary treatment planning enhances care and development may represent an area where external partners can help. Commitment to the use of protocols is evident, but current international guidelines may lack relevance; the development of resources that reflect the capacity and needs of LMICs is required. In some LMICs, there are already leading centres experienced in paediatric radiotherapy where patient care approximates to that in HICs. These centres have the potential to drive improvements in service, training, mentorship and research in their regions and ultimately to improve the care and outcomes for paediatric cancer patients. © 2020 The Royal College of Radiologists	Developing countries; paediatric cancer; radiation oncology; radiotherapy	Article; cancer patient; cancer radiotherapy; cancer survival; child; childhood cancer; clinical decision making; clinical practice; clinical protocol; controlled study; diagnostic imaging; female; health care personnel; health care planning; high income country; human; low income country; major clinical study; male; middle income country; overall survival; pediatrics; practice guideline; quality of life; radiation oncology; social support; developing country; international cooperation; neoplasm; nuclear energy; oncology; Child; Developing Countries; Humans; International Agencies; Medical Oncology; Neoplasms; Nuclear Energy; Radiation Oncology	Elsevier Ltd	09366555	33250288	Article	Q1	1037	4156	View
561	Nadzir M.M., Nurhayati R.W., Idris F.N., Nguyen M.H.	8668648100;55748436600;57194239683;55319059400;	Biomedical applications of bacterial exopolysaccharides: A review	2021	Polymers	13	4	530	1	25	9	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101211712&doi=10.3390%2fpolym13040530&partnerID=40&md5=0563148d938735dbc6e7b156a85abe90	School of Chemical Engineering, Engineering Campus, Universiti Sains Malaysia, Nibong Tebal, 14300, Malaysia; Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Faculty of Biotechnology, Chemistry and Environmental Engineering, Phenikaa University, Hanoi, 12116, Viet Nam; Bioresource Research Center, Phenikaa University, Hanoi, 12116, Viet Nam	Nadzir, M.M., School of Chemical Engineering, Engineering Campus, Universiti Sains Malaysia, Nibong Tebal, 14300, Malaysia; Nurhayati, R.W., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia, Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, 10430, Indonesia; Idris, F.N., School of Chemical Engineering, Engineering Campus, Universiti Sains Malaysia, Nibong Tebal, 14300, Malaysia; Nguyen, M.H., Faculty of Biotechnology, Chemistry and Environmental Engineering, Phenikaa University, Hanoi, 12116, Viet Nam, Bioresource Research Center, Phenikaa University, Hanoi, 12116, Viet Nam	Bacterial exopolysaccharides (EPSs) are an essential group of compounds secreted by bacteria. These versatile EPSs are utilized individually or in combination with different materials for a broad range of biomedical field functions. The various applications can be explained by the vast number of derivatives with useful properties that can be controlled. This review offers insight on the current research trend of nine commonly used EPSs, their biosynthesis pathways, their characteristics, and the biomedical applications of these relevant bioproducts. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.	Alginate; Bacteria; Biomedical; Cellulose; Dextran; Exopolysaccharides; Gellan; Hyaluronic acid; Levan; Xanthan gum	Biochemistry; Bioproducts; Medical applications; Biomedical applications; Biomedical fields; Biosynthesis pathways; Exopolysaccharides; Research trends; Useful properties; Polysaccharides	MDPI AG	20734360		Review	Q1	770	6319	View
603	Clarissa A., Sutandi N., Fath A.A.	57201653912;57201654034;57257442900;	Stem-Cell Therapy Following High-Dose Chemotherapy in Advanced Retinoblastoma: A Systematic Review	2021	Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)	10	4		397	407		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114846321&doi=10.1097%2fAPO.0000000000000372&partnerID=40&md5=bd9b021766dfa6bd6c9f108c62bd4c7c	Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia	Clarissa, A., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Sutandi, N.; Fath, A.A.	PURPOSE: To analyze the risk and benefit of high-dose chemotherapy followed by stem cell transplantation (HDCT-SCT) treatment in patients with advanced retinoblastoma. DESIGN: Systematic review. METHODS: A comprehensive literature search from 4 online databases, including PubMed, Scopus, EBSCO, and Cochrane was done for original studies evaluating the use of HDCT followed by SCT in the treatment of patients with advanced retinoblastoma. The last search was performed on April 15, 2020. RESULTS: A total of 35 studies consisting of 160 patients were considered suitable for inclusion. After HDCT-SCT treatment, 108/160 (67.5%) patients were alive with no evidence of disease at the last follow-up. The incidence of secondary malignancy in our data was also relatively low, which was 16/160 (10%) patients. The side effects were mainly hematological and gastrointestinal toxicities. The prognosis for metastatic cases especially the one to the central nervous system (CNS) remains poor, as shown in our data that 22 of 44 (50%) patients died due to the evidence of disease, and 12 of 44 (27%) patients acquired CNS relapse and died. CONCLUSIONS: HDCT-SCT is a promising treatment option in patients with advanced retinoblastoma. The use of HDCT-SCT in CNS metastases needs to be carefully considered, possibly by adding thiotepa or topotecan to improve tumor control. Further randomized clinical trials are needed to draw firm conclusion regarding its safety and efficacy. Copyright © 2021 Asia-Pacific Academy of Ophthalmology. Published by Wolters Kluwer Health, Inc. on behalf of the Asia-Pacific Academy of Ophthalmology.		antineoplastic agent; human; multimodality cancer therapy; retina tumor; retinoblastoma; stem cell transplantation; tumor recurrence; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Humans; Neoplasm Recurrence, Local; Retinal Neoplasms; Retinoblastoma; Stem Cell Transplantation	NLM (Medline)	21620989	33481395	Article	#N/A	#N/A	#N/A	View
622	Budianto I.R., Firmansyah A., Moenadjat Y., Jusuf A.A., Soetikno V.	56072591000;57430911900;57190371576;57192275719;36769252100;	In vivo model of Hirschsprung-associated enterocolitis using benzalkonium chloride	2021	Medical Journal of Indonesia	30	4		239	244		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123725324&doi=10.13181%2fmji.oa.215339&partnerID=40&md5=0d7ad27ed35c326eece4ebc9bb2d637b	Biomedical Doctoral Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, School of Medicine and Health Sciences, Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia; Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Budianto, I.R., Biomedical Doctoral Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Surgery, School of Medicine and Health Sciences, Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia; Firmansyah, A., Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Moenadjat, Y., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jusuf, A.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soetikno, V., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	BACKGROUND Hirschsprung-associated enterocolitis (HAEC) is a life-threatening complication of Hirschsprung’s disease. Studies using animal models on the pathogenesis of HAEC are limited. Thus, this study aimed to establish a rat model of HAEC using topical application of 0.1% benzalkonium chloride (BAC) in the sigmoid colon. METHODS 55 male Sprague Dawley rats aged 10−12 weeks old were separated into 11 groups. The control group (n = 5) was euthanized on day-7, and the other 10 groups (n = 5 in each group) treated with 0.1% BAC in the sigmoid colon for 15 min to induce Hirschsprung’s disease were euthanized on day-7,-10,-12,-14,-17,-19,-21,-23,-25, and-28. The sigmoid colon was excised, fixed in formalin, and sectioned for histological examinations with hematoxylin and eosin staining. The degree of HAEC was compared within all groups. RESULTS Rats that were sacrificed on day-7 to-12 showed the 1st degree or early HAEC, which was most likely caused by BAC application. The 2nd degree of HAEC occurred in rats that were sacrificed on day-14 that showed a macrophage infiltration in the sigmoid colon, thus fulfilled the initial criteria for HAEC (p = 0.0025 versus control). The degree of enterocolitis increased with time, and the highest degree was found in rats that were sacrificed on day-28 (p<0.001 versus control). CONCLUSIONS Topical application of 0.1% BAC for 15 min was successfully produced HAEC model in rats, which was occurred on day-14 after the application. This model provides a useful resource for further research on the pathogenesis of HAEC. © 2021 Authors.	Animal model; Colitis; Ganglions; Hirschsprung’s disease	benzalkonium chloride; eosin; hematoxylin; isoflurane; ketamine; xylazine; aganglionosis; animal model; animal tissue; anorexia; Article; autopsy; cell proliferation; cervical spine dislocation; controlled study; crypt cell; enterocolitis; Hirschsprung disease; in vivo study; laparotomy; macrophage; male; mucosa ulceration; necrosis; neutrophil chemotaxis; nonhuman; rat; sham procedure; sigmoid; Sprague Dawley rat; ulcer	Faculty of Medicine, Universitas Indonesia	08531773		Article	Q4	164	21905	View
623	Winarto H.	54080645300;	The importance of identification for a stress urinary incontinence after pelvic orgaprolapse vaginal repair	2021	Medical Journal of Indonesia	30	4		237	238		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123709235&doi=10.13181%2fmji.ed.215971&partnerID=40&md5=ee09f6c4f49a5e6e13609c2191a488f0	Medical Journal of Indonesia, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia	Winarto, H., Medical Journal of Indonesia, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia	[No abstract available]		editorial; Editorial; female; human; pelvic organ prolapse; postoperative complication; stress incontinence; vagina reconstruction	Faculty of Medicine, Universitas Indonesia	08531773		Editorial	Q4	164	21905	View

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