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781 |
Hidayat M., Handayani D., Nurwidya F., Andarini S.L. |
56435992700;57219413838;55221773800;8716259500; |
Hyperinflammation syndrome in covid-19 disease: Pathogenesis and potential immunomodulatory agents [Covid-19 hastalığında hiperenflamasyon sendromu: Patogenez ve potansiyel immünomodülatuvar ajanlar] |
2021 |
Turkish Journal of Immunology |
9 |
1 |
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1 |
11 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108585451&doi=10.5222%2fTJI.2021.92486&partnerID=40&md5=e11fbb69c1d65d6dcdb052da54e5cf96 |
Faculty of Medicine, University of Mataram, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia |
Hidayat, M., Faculty of Medicine, University of Mataram, Indonesia; Handayani, D., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia; Nurwidya, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia; Andarini, S.L., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia |
The coronavirus disease 2019 (COVID-19) pandemic caused by infection of the SARS-CoV-2 virus has affected millions of people in the world. The pathogenesis and clinical manifestations of COVID-19 disease are tightly influenced by the host immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. In some condition, the immune response might be uncontrolled, giving rise to hyperinflammatory conditions marked by excessive release of proinflammatory cytokines (cytokine storms) in severe COVID-19 patients, which then can cause acute respiratory distress syndrome (ARDS), multiorgan failure, and death. Furthermore, treatment using immunomodulator agents including immunostimulatory and immunosuppressive agents can be an option in achieving successful treatment. In this review, we discuss the pathogenesis of the disease, including host immune responses to SARS-CoV-2 virus infection, and immune mechanisms which contribute to the disease severity and death as well as several potential immunomodulatory agents which can be used in the management of hyperinflammatory syndrome of severe COVID-19. © Turkish Journal of Immunlogy. |
Coronavirus disease 2019 (COVID-19); Cytokine storm; Hyperinflammation syndrome; Immunomodulatory treatment |
chloroquine; convalescent plasma; hydroxychloroquine; immunoglobulin; immunomodulating agent; interferon; interleukin 1 receptor blocking agent; interleukin 6 antibody; neutralizing antibody; sarilumab; tocilizumab; tumor necrosis factor inhibitor; adult respiratory distress syndrome; antibody dependent enhancement; coronavirus disease 2019; cytokine production; cytokine release; cytokine storm; disease severity; human; hyperinflammatory syndrome; immune response; immune system; immunosuppressive treatment; mortality; multiple organ failure; pandemic; Review; Severe acute respiratory syndrome coronavirus 2; signal transduction; stem cell transplantation; virus cell interaction; virus pathogenesis; virus replication |
Turkish Society of Immunology |
1301109X |
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Review |
Q4 |
115 |
27813 |
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782 |
Palupi-Baroto R., Hermawan K., Murni I.K., Nurlitasari T., Prihastuti Y., Sekali D.R.K., Ambarsari C.G. |
56495463300;57224908584;55734483200;57224895124;57224909176;57224897130;57211850895; |
High fibroblast growth factor 23 as a biomarker for severe cardiac impairment in children with chronic kidney disease: A single tertiary center study |
2021 |
International Journal of Nephrology and Renovascular Disease |
14 |
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165 |
171 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108541273&doi=10.2147%2fIJNRD.S304143&partnerID=40&md5=ba9cd0eab6e18711499e83b6c4812aa7 |
Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Department of Child Health, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Palupi-Baroto, R., Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Hermawan, K., Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Murni, I.K., Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Nurlitasari, T., Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Prihastuti, Y., Department of Child Health, Faculty of Medicine, Public Health and Nursing Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia; Sekali, D.R.K., Department of Child Health, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ambarsari, C.G., Department of Child Health, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Left ventricular hypertrophy (LVH) is the most common cardiac abnormality in chronic kidney disease (CKD). Changes in cardiac geometry and functions may occur in an early stage and worsen as CKD progresses. Recently, the role of fibroblast growth factor 23 (FGF23) is being highlighted and investigated in CKD-related cardiomyopathy. However, only a few studies have reviewed the utilization of FGF23 as a diagnostic biomarker in the pediatric CKD population. Purpose: This study aimed to identify the role of FGF23 as a biomarker in assessing cardiac changes in children with CKD. Patients and Methods: We conducted a cross-sectional study that involved children aged 2 to 18 years old with CKD stages 2 to 5D in Dr. Sardjito General Hospital, Yogyakarta, Indonesia. The level of FGF23 was measured using an immunometric enzyme-linked immunosorbent assay. LVMI, RWT, and left ventricular ejection fraction (LVEF) were assessed with echocardiography. Receiver-operating characteristic (ROC) analyses were conducted to assess the diagnostic performance of FGF23 in detecting LVH with impaired contractility. Results: A total of 43 children with CKD stages 2 to 5D were included, among whom the prevalence of LVH diagnosis was 95.35%. The area under the curve (AUC) of FGF23 to assess LVH and systolic dysfunction was 0.82 (95% CI 0.62–1.0), and the optimal cutoff point was 1413 RU/mL (sensitivity 80%, specificity 78.95%). The median concentration of FGF23 increased with the decreasing eGFR and the increasing LVMI although the systolic and diastolic functions were preserved. Conclusion: FGF23 might be used as an early biomarker to detect cardiac changes in pediatric CKD patients, particularly for LVH and impaired systolic function among children with CKD stage 2 and higher. © 2021 Palupi-Baroto et al. |
Dialysis; End-stage kidney disease; FGF23; Left ventricular hypertrophy; Ventricular ejection fraction |
biological marker; fibroblast growth factor 23; adolescent; adult; anemia; area under the curve; Article; child; chronic kidney failure; clinical article; cross-sectional study; diabetic nephropathy; diagnostic test accuracy study; diagnostic value; disease severity; echocardiography; enzyme linked immunosorbent assay; estimated glomerular filtration rate; female; glomerulonephritis; heart left ventricle contractility; heart left ventricle contraction; heart left ventricle ejection fraction; heart left ventricle filling; heart left ventricle mass; heart ventricle hypertrophy; human; hypertension; Indonesia; kidney agenesis; kidney calcification; kidney dysplasia; kidney hypoplasia; lupus erythematosus nephritis; male; nephrotic syndrome; obstructive uropathy; preschool child; prevalence; r |
Dove Medical Press Ltd |
11787058 |
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Article |
Q2 |
846 |
5589 |
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783 |
Prabowo K.A., Ellenzy G., Wijaya M.C., Kloping Y.P. |
57224859187;57224861188;57221739074;57205266766; |
Impact of Work from Home Policy during the COVID-19 Pandemic on Mental Health and Reproductive Health of Women in Indonesia |
2021 |
International Journal of Sexual Health |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108422054&doi=10.1080%2f19317611.2021.1928808&partnerID=40&md5=0d311414603955c5b93af73ca9ec0c60 |
Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Department of Psychiatry, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Prabowo, K.A., Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Ellenzy, G., Department of Psychiatry, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Wijaya, M.C., Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Kloping, Y.P., Faculty of Medicine, Airlangga University, Surabaya, Indonesia |
Objectives: This study aimed to assess the impact of work from home (WFH) during the COVID-19 pandemic on the mental health and reproductive health of women in Indonesia. To the best of our knowledge, this is the first study evaluating the impact of WFH policy on said health aspects in Indonesia. Methods: We conducted an observational study with a cross-sectional approach using an online survey among premenopausal married women in Indonesia. The survey included the General Health Questionnaire (GHQ-12) for psychological distress, average sexual intercourse frequency (SIF) per week, contraception use, change of menstrual pattern, and desire for having children. To analyze the effect of WFH, the participants were divided into groups based on their WFH compliance: (1) Both couples (her and her spouse) work from home, (2) Only the wife works from home, (3) Only the husband works from home, and (4) Neither works from home. Results: 348 women were included in this study. Psychological distress occurred in 48.0% (n = 167) participants. No significant difference was found between the WFH groups (χ 2[3, N = 348] = 2.077, p =.56)). The average weekly SIF was found to be significantly fewer during WFH (T = 5014, z = −5.598, p <.001). However, only 22.7% (n = 79) participants reported the use of contraception and 52.9% (n = 196) participants still wanted to have children. Change of menstrual pattern occurred in 31.6% (n = 110) participants and were significantly correlated to psychological distress (rs =.126, p =.018). Conclusions: WFH does not aggravate the effect of the pandemic on women's mental and reproductive health in Indonesia. A significant number of them still desire to have children and contraceptive prevalence is low. © 2021 Taylor & Francis Group, LLC. |
COVID-19; mental health; pandemic; Quarantine; reproductive health |
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Routledge |
19317611 |
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Article |
Q1 |
809 |
5958 |
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784 |
Bustamam A., Sarwinda D., Paradisa R.H., Victor A.A., Yudantha A.R., Siswantining T. |
36815737800;56119401500;57221562575;57191055282;55489644900;57193446800; |
Evaluation of convolutional neural network variants for diagnosis of diabetic retinopathy |
2021 |
Communications in Mathematical Biology and Neuroscience |
2021 |
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42 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108354325&doi=10.28919%2fcmbn%2f5660&partnerID=40&md5=46f614ba3ad44a65354d6ec3e2b41ab1 |
Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Bustamam, A., Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Sarwinda, D., Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Paradisa, R.H., Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Victor, A.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Yudantha, A.R., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siswantining, T., Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia |
Diabetic Retinopathy (DR) is a long-term complication of Diabetes Mellitus (DM) that impairs vision. This stage occurs in visual impairment and blindness if treated late. DR identified through scanning fundus images. A technique on classifying DR in fundus images is the deep learning approach, one of the methods of implementing machine learning. In this study, the Convolutional Neural Networks (CNN) method applied with the ResNet-50 and DenseNet-121 architectures. The data adopted in this analysis was generated from DIARETDB1, an online database containing fundus images. Then, the pre-processing stage is carried out on the fundus image to improve model performance, such as selected the green channel from the images and inverted it, converted the images into grayscale images, and applied Contrast Limited Adaptive Histogram Equalization (CLAHE) for uniform contrast in the images. The outcome of this research indicates that the ResNet-50 model is better than DenseNet-121 in detecting DR. The most reliable results from the ResNet-50 model's case testing are accuracy, precision, and recall of 95%, 98%, and 96% respectively. © 2021, SCIK Publishing Corporation. All rights reserved. |
Deep learning; Densenet; Diabetic retinopathy; Fundus image; Resnet |
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SCIK Publishing Corporation |
20522541 |
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Article |
Q4 |
189 |
20081 |
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785 |
Kartini D., Taher A., Panigoro S., Setiabudy R., Jusman S., Haryana S., Murdani A., Rustamadji P., Karisyah A., Rasyid S. |
57215490523;7005269743;56790104300;6602316235;36518792100;6507708439;57224770678;55321572200;57224765948;57224779056; |
Melatonin effect on hypoxia inducible factor-1a and clinical response in patients with oral squamous cell carcinoma receiving neoadjuvant chemotherapy: A randomized controlled trial |
2021 |
Journal of Carcinogenesis |
20 |
1 |
5 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108295574&doi=10.4103%2fjcar.JCar_19_20&partnerID=40&md5=7ba744b8de3c6ab6a11dd7b89d27e34a |
Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biochemistry and Molecular Genetics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology and Cell Biology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kartini, D., Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Taher, A., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Panigoro, S., Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiabudy, R., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jusman, S., Department of Biochemistry and Molecular Genetics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Haryana, S., Department of Histology and Cell Biology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Murdani, A., Division of Gastroenterology and Hepatology, Department of Internal Medicine, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rustamadji, P., Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Karisyah, A., Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rasyid, S., Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Context: Chemoresistance is a major issue in patients with locally advanced oral squamous cell carcinoma (OSCC). In this study, we evaluated the effectiveness of melatonin in conjunction with neoadjuvant chemotherapy (NC) on hypoxia-inducible factor-1α (HIF-1α) expression and clinical response in locally advanced OSCC patients. Aims: To study the effects of melatonin on HIF-1α expression and its effect on the clinical response of patients with locally advanced OSCC. Settings and Design: A randomized controlled trial was conducted, wherein patients were recruited from several hospitals in Jakarta, Indonesia. Patients were randomized into two groups using computerized block randomization. Subjects and Methods: Both groups were given NC, with treatment group receiving melatonin. Outcomes measured in this study were HIF-1α expression from tissue samples and clinical response based on the RECIST 1.1 criteria. Twenty-five patients completed the study protocol and were included in the data analysis. Statistical Analysis Used: Shapiro-Wilk test was used to test the data normality. For data with normal distribution, we conducted an independent t-test to compare between the two groups. Data with abnormal distribution were analyzed using Mann-Whitney U-test. The mean difference between the two groups was analyzed using Shapiro-Wilk normality test. Results: Our study showed a significant decrease in HIF-1α expression in the melatonin group compared to the placebo group (P < 0.05, relative risk 3.08). However, the degree of reduction of HIF-1α expression in the melatonin group did not differ significantly (P = 0.301). Conclusions: Our study showed that melatonin administered at 20 mg/day could reduce the expression of HIF-1α and residual tumor percentage, but did not affect the clinical response in OSCC patients. © 2021 Annual Reviews Inc.. All rights reserved. |
Chemoresistance; hypoxia-inducible factor-1α; melatonin; oral squamous cell carcinoma |
carboplatin; cisplatin; docetaxel; fluorouracil; hypoxia inducible factor 1alpha; melatonin; messenger RNA; placebo; adult; advanced cancer; adverse drug reaction; aged; Article; cancer combination chemotherapy; cancer patient; cancer staging; cancer tissue; clinical article; clinical outcome; comparative study; computerized block randomization; controlled study; data analysis software; double blind procedure; drowsiness; fatigue; female; headache; human; human tissue; incisional biopsy; Indonesia; Karnofsky Performance Status; male; microcapsule; mouth squamous cell carcinoma; neoadjuvant chemotherapy; parallel design; protein expression; randomization; randomized controlled trial; real time polymerase chain reaction; response evaluation criteria in solid tumors; risk factor; sleep disord |
Wolters Kluwer Medknow Publications |
09746773 |
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Article |
Q1 |
2771 |
735 |
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786 |
Sahar N., Birowo P., Thuffi R., Muharram A.R., Ode Z.W., Subahar R., Yazid F., Handayani S.I., Prasasty V.D. |
57212464367;6504153311;57212475033;57224640920;57222324817;57224626083;57207890516;57207819540;56019989700; |
Fsh receptor and ki-67 protein expressions of endometrial macaque in mid-luteal phase after exposure to various doses of recombinant fsh and fixed-dose of gnrh agonist |
2021 |
OnLine Journal of Biological Sciences |
21 |
2 |
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260 |
266 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108083891&doi=10.3844%2fojbsci.2021.260.266&partnerID=40&md5=6752f9329d0eda8fbfaee279007348a8 |
Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departemen of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia |
Sahar, N., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Birowo, P., Departement of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Thuffi, R., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muharram, A.R., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ode, Z.W., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Subahar, R., Departemen of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yazid, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Handayani, S.I., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prasasty, V.D., Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia |
There are many advances in Assisted Reproductive Technologies (ARTs). However, implantation rates are still low. The embryo implantation is a mutual interaction between the blastocyst and endometrium. This study aimed to investigate the endometrial cell proliferation stimulated by recombinant Follicle-Stimulating Hormone (rFSH) in various doses by looking at FSH-Receptor (FSHR) and Ki-67 protein expressions. The studied samples were Stored Biological Materials (SBMs) from the endometrial tissue of Macaca nemestrina. All sample was obtained from fifteen macaques, divided into four groups, which three groups were treated with rFSH and given fixed-dose (160 µg/day) of Gonadotropin-Releasing Hormone (GnRH) agonists and one control group as normal group. The three treated macaque groups were stimulated with 30, 50 and 70 IU doses of rFSH. There was no significant difference in various doses of rFSH towards FSHR and Ki-67 expressions in endometrial tissue of M. nemestrina. Therefore, this result did not significantly correlate FSHR and Ki-67 expressions in the endometrial tissue of M. nemestrina after rFSH administration. Moreover, the highest rFSH dose did not reduce the FSHR and Ki-67 expressions and there was no correlation between FSHR and Ki-67 expressions. It can be concluded that macaque endometrial cells were receptive to the given dosages of rFSH. © 2021 Nurhuda Sahar, Ponco Birowo, Rosalina Thuffi andhea Raden Muharram, Zulhulaifah Wa Ode, Rijal Subahar, Fatmawaty Yazid, Supri Irianti Handayani and Vivitri Dewi Prasasty. |
Endometrial Tissue; FSHR; Macaque; Proliferation Marker; RFSH |
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Science Publications |
16084217 |
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Article |
Q4 |
152 |
23000 |
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787 |
Rahman I.A., Rasyid N., Birowo P., Atmoko W. |
57211646827;56245069300;6504153311;57193125664; |
Effects of renal transplantation on erectile dysfunction: a systematic review and meta-analysis |
2021 |
International Journal of Impotence Research |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107770401&doi=10.1038%2fs41443-021-00419-6&partnerID=40&md5=6fab70d2b92ac45bd379994f51e6be3a |
Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rahman, I.A., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rasyid, N., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Birowo, P., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Atmoko, W., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Erectile dysfunction (ED) is a major global health burden commonly observed in patients with end-stage renal disease (ESRD). Although renal transplantation improves the problem in some patients, it persists in ≈20–50% of recipients. Studies regarding the effects of kidney transplantation on ED present contradictory findings. We performed a systematic review to summarise the effects of kidney transplantation on ED. A systematic literature search was performed across PubMed, Cochrane, and Scopus databases in April 2020. We included all prospective studies that investigated the pre and posttransplant international index of erectile function (IIEF-5) scores in recipients with ED. Data search in PubMed and Google Scholar produced 1326 articles; eight were systematically reviewed with a total of 448 subjects. Meta-analysis of IIEF-5 scores showed significant improvements between pre and post transplantation. Our findings confirm that renal transplantation improves erectile function. Furthermore, transplantation also increases testosterone level. However, the evidence is limited because of the small number of studies. Further studies are required to investigate the effects of renal transplantation on erectile function. © 2021, The Author(s). |
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Springer Nature |
09559930 |
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Article |
Q2 |
508 |
9947 |
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788 |
Nasrun M.W.S., Kusumaningrum P., Redayani P., Lahino H.L., Mardhiyah F.S., Basfiansa A.D., Nadila N. |
57196216137;55645015800;57224504437;57224499395;57224509939;57224506079;57224506058; |
Relationship between Quality of Life of People with Dementia and Their Caregivers in Indonesia |
2021 |
Journal of Alzheimer's Disease |
81 |
3 |
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1311 |
1320 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107718718&doi=10.3233%2fJAD-201550&partnerID=40&md5=1552dbf607377e4dc97ac5eb8d635a1d |
Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Nasrun, M.W.S., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kusumaningrum, P., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Redayani, P., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Lahino, H.L., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Mardhiyah, F.S., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Basfiansa, A.D., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nadila, N., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Caregivers, as one of the most important roles in caring for a person with dementia, have a challenging task. Therefore, maintaining the quality of life (QoL) of caregivers is an integral part of dementia care. Objective: To explore the relationship between the QoL of people with dementia and their caregivers in Indonesia. Methods: This is a cross-sectional study using binary correlations to analyze the relationship between people with dementia and caregivers' QoL. Conducted in Cipto Mangunkusumo Hospital in Jakarta, the subjects were 42 people diagnosed with dementia according to the PPDGJ-III (adapted from the ICD 10) and 42 primary caregivers with at least 6 hours duration of caregiving per day. The QoL of people with dementia was measured by EuroQol-5D and VAS EQ-5D, while severity of dementia was measured by MMSE. Caregivers underwent an interview using WHO Quality of Life Instrument (WHOQOL-BREF) and NPI. Results: Most caregivers were women, aged 40-70 years old. The study found caregivers' QoL environmental domain strongly correlated with people with dementia's QoL (r = 0.839). Severity of dementia had a strong correlation with caregivers' QoL physical domain (r = 0.946). Age, duration of caregiving per day, period of care provided by caregivers, and caregiver's distress had a strong correlation with caregiver QoL for specific domains. Conclusion: There was a strong correlation between people with dementia's QoL and caregiver QoL, so in managing dementia, clinicians should consider caregivers' wellbeing as an essential part significantly affecting the quality of elderly care improvement. © 2021-IOS Press. All rights reserved. |
Caregivers; dementia; Indonesia; quality of life |
adult; age; aged; agitation; apathy; Article; caregiver; clinical article; correlational study; cross-sectional study; dementia; demography; depression; disease severity; European Quality of Life 5 Dimensions questionnaire; female; human; Indonesia; male; mental disease assessment; middle aged; Mini Mental State Examination; neuropsychiatry inventory; quality of life; questionnaire; sleep disorder; social interaction; WHOQOL-BREF; caregiver; dementia; psychology; quality of life; very elderly; Adult; Aged; Aged, 80 and over; Caregivers; Cross-Sectional Studies; Dementia; Female; Humans; Indonesia; Male; Middle Aged; Quality of Life; Surveys and Questionnaires |
IOS Press BV |
13872877 |
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33935083 |
Article |
Q1 |
1677 |
1840 |
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789 |
Rhatomy S., Dilogo I.H. |
57204509883;56161962800; |
Core decompression and biological treatment in osteonecrosis of the hip due to systemic lupus erythematosus, 8-year follow-up: A case report |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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74 |
79 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107632892&doi=10.3889%2foamjms.2021.5798&partnerID=40&md5=d126812c5dab6196ca3a6f0a5513b86a |
Department of Orthopaedic and Traumatology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Soeradji Tirtonegoro General Hospital, Yogyakarta, Indonesia; Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rhatomy, S., Department of Orthopaedic and Traumatology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Soeradji Tirtonegoro General Hospital, Yogyakarta, Indonesia; Dilogo, I.H., Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Osteonecrosis most commonly affects the femoral head, especially in middle-aged adults. It can be caused by trauma, chronic inflammation, or infection. It leads to collapse of the entire femoral head and culminates with total hip replacement. CASE REPORT: A 29-year-old female with systemic lupus erythematosus (SLE) had a chief complaint of bilateral hip pain. She was diagnosed with early osteonecrosis of the femoral head (FICAT stage II) using magnetic resonance imaging and core decompression surgery was performed using three small diameter (4 mm) drillings and added biological treatment. She was evaluated with a visual analog scale (VAS), Harris hip score (HHS), and plain radiography in the pre-operative stage and post-operative follow-up. RESULTS: Functional outcome at 8-year follow-up showed improvement with significantly decreased VAS (pre-operative: 5, post-operative: 0), significant improvement of HHS from 52.725 points (poor) pre-operative to 92.025 points (excellent) post-operative, and subsided femoral head lesion. CONCLUSIONS: Surgical decompression and biological treatment result in decreased intraosseous pressure and enhanced osteogenesis. It can restrict the SLE disease progression and limit the number of cell death. © 2021 Sholahuddin Rhatomy, Ismail Hadisoebroto Dilogo. |
Avascular necrosis; Core decompression; Hip; Osteonecrosis; Systemic lupus erythematosus |
corticosteroid; adult; antalgic lump; arteriovenous shunt; Article; avascular necrosis; bone development; bone graft; bone necrosis; bone radiography; case report; clinical article; clinical examination; daily life activity; decompression surgery; differential diagnosis; disease exacerbation; female; femoral head; fluoroscopy; follow up; functional outcome; Harris hip score; hip osteoarthritis; hip pain; hip replacement; human; intermittent pain; morphogenesis; nuclear magnetic resonance imaging; ossification; osteogenesis imperfecta; physical examination; preoperative evaluation; range of motion; systemic lupus erythematosus; thigh region; visual analog scale; weight bearing |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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790 |
Wardhani S.O., Fajar J.K., Wulandari L., Soegiarto G., Purnamasari Y., Asmiragani A., Maliga H.A., Ilmawan M., Seran G., Iskandar D.S., Ndapa C.E., Hamat V., Wahyuni R.A., Cyntia L.O.S., Maarang F.M., Beo Y.A., Adar O.A., Rakhmadhan I.M., Shantikaratri E.T., Putri A.S.D., Wahdini R., Broto E.P., Suwanto A.W., Tamara F., Mahendra A.I., Winoto E.S., Krisna P.A., Harapan H. |
57193196381;56156139600;52464692000;57193717004;57208736262;57222959533;57222334227;57217182580;57224455829;57224438531;57224439885;57224449332;57224455629;57224455121;57224456392;57224446473;57224439160;57224438662;57224448392;57224441818;57224441565;57224444725;57224449941;57192950403;57202301766;57215222980;57215221274;55844857500; |
Association between convalescent plasma and the risk of mortality among patients with COVID-19: A meta-analysis |
2021 |
F1000Research |
10 |
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64 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107586864&doi=10.12688%2ff1000research.36396.3&partnerID=40&md5=8ed63ca0af3edd475d763e27b3e86db9 |
Division of Hematology and Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Biomedical Sciences, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Department of Midwifery, Faculty of Medicine, University Brawijaya, Malang, 65145, Indonesia; Department of Nursing, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia |
Wardhani, S.O., Division of Hematology and Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Fajar, J.K., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Wulandari, L., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Soegiarto, G., Division of Allergy and Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Purnamasari, Y., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Asmiragani, A., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Maliga, H.A., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Ilmawan, M., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Seran, G., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Iskandar, D.S., Department of Biomedical Sciences, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Ndapa, C.E., Department of Midwifery, Faculty of Medicine, University Brawijaya, Malang, 65145, Indonesia; Hamat, V., Department of Midwifery, Faculty of Medicine, University Brawijaya, Malang, 65145, Indonesia; Wahyuni, R.A., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Cyntia, L.O.S., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Maarang, F.M., Department of Nursing, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Beo, Y.A., Department of Nursing, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Adar, O.A., Department of Midwifery, Faculty of Medicine, University Brawijaya, Malang, 65145, Indonesia; Rakhmadhan, I.M., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Shantikaratri, E.T., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Putri, A.S.D., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Wahdini, R., Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Broto, E.P., Department of Neurosurgery, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Suwanto, A.W., Department of Radiology, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Tamara, F., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Mahendra, A.I., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Winoto, E.S., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Krisna, P.A., Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, 65145, Indonesia; Harapan, H., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia |
Background: Convalescent plasma (CCP) has been used for treating some infectious diseases; however, the efficacy of CCP in coronavirus disease 2019 (COVID-19) remains controversial. The aim of this research was to assess the efficacy of CCP as an adjunctive treatment in COVID-19 patients. Methods: Embase, PubMed, Web of Science, Cochrane and MedRix were searched for potentially relevant articles. All included papers were assessed for the quality using modified Jadad scale and Newcastle-Ottawa scale for randomized controlled trial (RCT) and non - RCT, respectively. We used a Q test and Egger test to assess the heterogeneity and publication bias among studies, respectively. Mortality rates between patients treated with standard treatment and standard treatment with CCP were compared using a Z test. Results: A total of 12 papers consisting of three cross-sectional studies, one prospective study, five retrospective studies, and three RCT studies were included in our analysis. Of them, a total of 1,937 patients treated with CCP and 3,405 patients without CCP were included. The risk of mortality was 1.92-fold higher in patients without CCP compared to patients treated with CCP (OR: 1.92; 95%CI: 1.33, 2.77; p=0.0005). In severe COVID-19 sub-group analysis, we found that patients without CCP had a 1.32 times higher risk of mortality than those treated with CCP (OR: 1.32; 95%CI: 1.09, 1.60; p=0.0040). Conclusions: CCP, as adjunctive therapy, could reduce the mortality rate among COVID-19 patients. © 2021 Wardhani SO et al. |
Convalescent plasma; COVID-19; Mortality; Outcomes; Passive immunization |
convalescent plasma; Article; clinical effectiveness; clinical observation; consensus; coronavirus disease 2019; correlation analysis; data analysis software; disease association; disease severity; Egger test; fixed effect model; forest plot; high risk patient; human; kappa statistics; meta analysis; mortality risk; Newcastle-Ottawa scale; nonhuman; outcome assessment; passive immunization; publication bias; quality control; random effect model; randomized controlled trial (topic); risk reduction; sample size; statistical analysis; statistical model; study design; subgroup analysis; systematic review; Coronavirus infection; therapy; treatment outcome; Coronavirus Infections; COVID-19; Humans; Immunization, Passive; SARS-CoV-2; Treatment Outcome |
F1000 Research Ltd |
20461402 |
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34136130 |
Article |
Q1 |
1099 |
3793 |
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