No records
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892 |
Dwinata M., Putera D.D., Hasan I., Raharjo M. |
57209231012;57210288025;12776850800;57212400550; |
SGLT2 inhibitors for improving hepatic fibrosis and steatosis in non-alcoholic fatty liver disease complicated with type 2 diabetes mellitus: a systematic review |
2021 |
Clinical and Experimental Hepatology |
6 |
4 |
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339 |
346 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099931230&doi=10.5114%2fceh.2020.102173&partnerID=40&md5=628a477d8f6d02f9de989db2ce816c8c |
Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Dwinata, M., Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Putera, D.D., Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Hasan, I., Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Raharjo, M., Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Aim of the study: To evaluate the efficacy of sodium/glucose cotransporter-2 inhibitors (SGLT2i) in improving hepatic fibrosis and steatosis of non-alcoholic fatty liver disease (NAFLD) patients with type 2 diabetes mellitus (T2DM). Material and methods: We searched CENTRAL, MEDLINE, and EMBASE and included any clinical trials involving patients with NAFLD and T2DM aged ≥ 18 years comparing efficacy of SGLT2i and other antidiabetic drugs in improving fibrosis and steatosis, irrespective of publication status, year of publication, and language. Results: Five clinical trials were included. One study reported significant improvements in the controlled attenuation parameter 314.6 ±61.0 dB/m to 290.3 ±72.7 dB/m (p = 0.04) in the SGLT2i group measured by transient elastography. In patients with significant fibrosis, dapagliflozin treatment significantly decreased the liver stiffness measurement from 14.7 ±5.7 kPa at baseline to 11.0 ±7.3 kPa after 24 weeks (p = 0.02). One study reported a significant decrease in liver fat content 16.2% to 11.3% (p < 0.001) in the SGLT2i group compared to the control (p < 0.001). Three studies reported significant improvement in the liver-to-spleen ratio in the SGLT2i group after treatment 0.96 (0.86-1.07) to 1.07 (0.98-1.14), p < 0.01, 0.80 ±0.24 to 1.00 ±0.18, p < 0.001, and 0.91 (0.64-1.04) to 1.03 (0.80-1.20), p < 0.001 respectively. All studies reported a significant decrease in alanine aminotransferase with SGLT2i. Conclusions: SGLT2i is associated with positive effects on hepatic steatosis measured by non-invasive modalities. Further studies are needed to confirm the impact of SGLT2i on hepatic fibrosis and steatosis. © 2020 Termedia Publishing House Ltd.. All rights reserved. |
Diabetes mellitus; Fibrosis; NAFLD; SGLT2 inhibitor; Steatosis |
alanine aminotransferase; dapagliflozin; empagliflozin; ipragliflozin; luseogliflozin; metformin; pioglitazone; sodium glucose cotransporter 2 inhibitor; adult; aged; alanine aminotransferase blood level; Article; comparative effectiveness; controlled study; diabetic patient; drug efficacy; elastography; female; human; liver fibrosis; liver stiffness; major clinical study; male; middle aged; non insulin dependent diabetes mellitus; nonalcoholic fatty liver; quasi experimental study; randomized controlled trial; systematic review; transient elastography; treatment outcome |
Termedia Publishing House Ltd. |
23921099 |
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Article |
Q4 |
394 |
12273 |
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925 |
Surja S.S., Adawiyah R., Houbraken J., Rozaliyani A., Sjam R., Yunihastuti E., Wahyuningsih R. |
57209258108;57208658742;12770401000;57203065912;23398458200;57221273925;6507268400; |
Talaromyces atroroseus in HIV and non-HIV patient: A first report from Indonesia |
2021 |
Medical Mycology |
58 |
4 |
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560 |
563 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085715396&doi=10.1093%2fMMY%2fMYZ090&partnerID=40&md5=9fec23d3506804c0bc622f42e14314ff |
Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia; Westerdijk Fungal Biodiversity Institute, Netherlands; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Parasitology, School of Medicine and Health Sciences, Universitas Katolik Indonesia, Atma Jaya, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia |
Surja, S.S., Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Indonesia, Department of Parasitology, School of Medicine and Health Sciences, Universitas Katolik Indonesia, Atma Jaya, Indonesia; Adawiyah, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia; Houbraken, J., Westerdijk Fungal Biodiversity Institute, Netherlands; Rozaliyani, A., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia; Sjam, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia; Yunihastuti, E., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia, Department of Internal Medicine, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia; Wahyuningsih, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia |
We performed morphology, molecular study and antifungal susceptibility test on 10 Talaromyces sp. isolates: eight clinical isolates (human immunodeficiency virus (HIV) and non-HIV-patient) and two isolates from rats. All strains produced red soluble pigment and microscopically showed Penicillium-like structure in room temperature and yeast-like structure in 37â—¦C. Based on molecular analysis, nine isolates were identified as Talaromyces atroroseus (including the isolates from rats) and one as T. marneffei. Our susceptibility result of T. marneffei supports the use of amphotericin B, itraconazole for talaromycosis marneffei management. Talaromyces atroroseus showed variable MIC to echinocandin, azole derivatives, 5-flucytosine and amphotericin B. © The Author(s) 2019. |
BenA; Indonesia; ITS; Talaromyces atroroseus; Talaromyces marneffei |
amphotericin B; anidulafungin; caspofungin; echinocandin; fluconazole; flucytosine; itraconazole; micafungin; posaconazole; pyrrole derivative; voriconazole; antifungal agent; antifungal susceptibility; Article; fungus isolation; human; Human immunodeficiency virus infected patient; Indonesia; mycosis; nonhuman; room temperature; Talaromyces; Talaromyces atroroseus; Talaromyces marneffei; talaromycosis; animal; classification; drug effect; genetics; Human immunodeficiency virus infection; Indonesia; isolation and purification; microbial sensitivity test; microbiology; pigmentation; rat; Talaromyces; Animals; Antifungal Agents; HIV Infections; Humans; Indonesia; Microbial Sensitivity Tests; Mycoses; Pigmentation; Rats; Talaromyces |
Oxford University Press |
13693786 |
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31504774 |
Article |
Q1 |
1004 |
4362 |
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926 |
Pranata R., Tondas A.E., Yonas E., Vania R., Yamin M., Chandra A., Siswanto B.B. |
57201973901;57211111907;57201987097;57208328436;23475706300;37025699200;14422648800; |
Differences in clinical characteristics and outcome of de novo heart failure compared to acutely decompensated chronic heart failure–systematic review and meta-analysis |
2021 |
Acta Cardiologica |
76 |
4 |
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410 |
420 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85083567065&doi=10.1080%2f00015385.2020.1747178&partnerID=40&md5=e965cfa89cbc748fb0b3f9ae692b173b |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Sriwijaya, Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX, United States; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Tondas, A.E., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Sriwijaya, Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Yamin, M., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Chandra, A., Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX, United States; Siswanto, B.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Background: Recent evidence showed that the characteristics and outcome of those with de novo heart failure (HF) and acutely decompensated chronic heart failure (ADCHF) were different. We aimed to perform a comprehensive search on the clinical characteristics and outcome of patients with de novo HF and ADCHF. Methods: We performed a comprehensive search on de novo/new onset acute HF vs ADCHF from inception up until December 2019. Results: There were 38320 patients from 15 studies. De novo HF were younger and, had less prevalent hypertension, diabetes mellitus, ischaemic heart disease, chronic obstructive pulmonary disease, atrial fibrillation, and history of stroke/transient ischaemic attack compared to ADCHF. Five studies showed a lower NT-proBNP in de novo HF patients, while one study showed no difference. Valvular heart disease as aetiology of heart failure was less frequent in de novo HF, and upon sensitivity analysis, hypertensive heart disease was more frequent in de novo HF. As for precipitating factors, ACS (OR 2.42; I2:89%) was more frequently seen in de novo HF, whereas infection was less frequently (OR 0.69; I2:32%) in ADCHF. De novo HF was associated with a significantly lower 3-month mortality (OR 0.63; I2:91%) and 1-year (OR 0.59; I2:59%) mortality. Meta-regression showed that 1-year mortality did not significantly vary with age (p =.106), baseline ejection fraction (p =.703), or HF reduced ejection fraction (p =.262). Conclusion: Risk factors, aetiology, and precipitating factors of HF in de novo and ADCHF differ. De novo HF also had lower 1-year mortality and 3-month mortality compared to ADCHF. © 2020 Belgian Society of Cardiology. |
acute decompensated heart failure; acute heart failure; characteristics; De novo heart failure; mortality; new onset heart failure |
amino terminal pro brain natriuretic peptide; creatinine; hemoglobin; acute coronary syndrome; acutely decompensated chronic heart failure; Article; atrial fibrillation; cardiovascular infection; cardiovascular mortality; cerebrovascular accident; Charlson Comorbidity Index; chronic obstructive lung disease; clinical feature; clinical outcome; coronary artery disease; de novo heart failure; diabetes mellitus; estimated glomerular filtration rate; heart arrhythmia; heart ejection fraction; heart failure; heart failure with reduced ejection fraction; hospital mortality; human; hypertension; ischemic heart disease; meta analysis; mortality rate; prevalence; risk factor; sensitivity analysis; smoking; systematic review; transient ischemic attack; valvular heart disease |
Taylor and Francis Ltd. |
00015385 |
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32252602 |
Article |
Q3 |
348 |
13410 |
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No records
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83 |
Triwidodo A., Rahyussalim A.J., Yulisa N.D., Pandelaki J., Huraiby L.S., Hadi I.A.N., Liosha F.Y., Dilogo I.H. |
57222626174;55212166100;57191033188;35759266900;57410470800;57345259600;57195941059;56161962800; |
Sacrum morphometry and spinopelvic parameters among the Indonesian population using computed tomography scans |
2021 |
Medicine (United States) |
100 |
47 |
e27955 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122758150&doi=10.1097%2fMD.0000000000027955&partnerID=40&md5=fcef27e030576bfa693c1f9a81c6abd9 |
Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Triwidodo, A., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rahyussalim, A.J., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yulisa, N.D., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pandelaki, J., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Huraiby, L.S., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hadi, I.A.N., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Liosha, F.Y., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Dilogo, I.H., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
This is a cross-sectional study. This study aims to describe the characteristics of sacrum vertebrae and spinopelvic parameters among the Indonesian population and compare them with studies from other populations. This study also intends to determine the sexual dimorphism of sacrum vertebrae and find the correlations between spinopelvic parameters. Morphometry of the sacrum is necessary for designing sacral prosthesis and instrumentations. Knowledge of spinopelvic parameters further supports the prosthesis installation procedure to restore the physiological spinal alignment of the patients. However, previous studies showed varied results among different populations. This is the first study to be conducted among the Indonesian population. Morphometric dimensions of sacrum vertebrae and the spinopelvic parameters (pelvic incidence, pelvic tilt, sacral slope, lumbar lordosis) were analyzed using thin-cut (1 mm) computed tomography images in 150 males and 150 females, aged 25 to 50 years without any spinal pathology. Generally, the size of the sacrum vertebrae was greater in males (P < .05). The sacral index, curvature index, and corporo-basal index were statistically different between genders (P < .001). Lumbar lordosis was the only spinopelvic parameter found significantly greater in females (P < .001). Significant positive correlations between all spinopelvic parameters, except for lumbar lordosis and pelvic tilt, were found in the present study (P < .001). The study serves as the first large series database of sacrum morphometric characteristics and spinopelvic parameters of the Indonesian population. There was significant gender-associated differences in various dimensions of sacrum vertebrae. The sacral index was found to be the most useful parameter for sex determination. There were strong significant positive correlations between various spinopelvic parameters. A comparison of populations revealed morphometric characteristic differences, which is proved to be critical in surgical implications. Copyright © 2021 the Author(s). |
Computed tomography scans; Indonesian population; Morphometry; Sacrum vertebrae; Spinopelvic parameters |
adult; cross-sectional study; diagnostic imaging; female; human; Indonesia; lumbar vertebra; male; middle aged; pelvis; sacrum; sexual characteristics; x-ray computed tomography; Adult; Cross-Sectional Studies; Female; Humans; Indonesia; Lumbar Vertebrae; Male; Middle Aged; Pelvis; Sacrum; Sex Characteristics; Tomography, X-Ray Computed |
Lippincott Williams and Wilkins |
00257974 |
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34964781 |
Article |
Q2 |
590 |
8573 |
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No records
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97 |
Miranda A.V., Wiyono L., Rocha I.C.N., Cedeño T.D.D., Lucero-Prisno D.E., III |
57222664687;57207889054;57223283646;57224097138;56051373800; |
Strengthening virology research in the association of Southeast Asian nations: Preparing for future pandemics |
2021 |
American Journal of Tropical Medicine and Hygiene |
105 |
5 |
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1141 |
1143 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119604704&doi=10.4269%2fajtmh.21-0589&partnerID=40&md5=98ad7364acccdc95ee57ef0ea9e65ed9 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; School of Medicine, Centro Escolar University, Manila, Philippines; Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom; Faculty of Management and Development Studies, University of the Philippines Open University, Los Baños, Laguna, Philippines |
Miranda, A.V., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiyono, L., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rocha, I.C.N., School of Medicine, Centro Escolar University, Manila, Philippines; Cedeño, T.D.D., School of Medicine, Centro Escolar University, Manila, Philippines; Lucero-Prisno, D.E., III, Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom, Faculty of Management and Development Studies, University of the Philippines Open University, Los Baños, Laguna, Philippines |
The Association of Southeast Asian Nations (ASEAN) region is known to be a global hotspot to viral outbreaks because of many factors. To limit the impact of future outbreaks, it is crucial for the ASEAN governments to strengthen regional virology research capacity. The ASEAN governments have collaborated in several virology initiatives, with the most recent being the establishment of the ASEAN Regional Center for Public Health Emergencies and Emerging Diseases. However, several challenges, including technology disparities, nationalistic tendencies, and the lack of public acceptance toward virus sharing, need to be addressed to maximize the region’s collaboration potential in virology research. We recommend the governments to 1) prioritize the strengthening of research capacities; 2) develop stronger cooperation and possible centralization of efforts on top of national capacities; 3) develop an equitable and secure research framework; and 4) improve the public awareness regarding the importance of regional public health responses. Copyright © 2021 by The American Society of Tropical Medicine and Hygiene |
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epidemic; human; medical research; organization and management; pandemic; Southeast Asia; virology; Asia, Southeastern; Biomedical Research; Disease Outbreaks; Humans; Pandemics; Virology |
American Society of Tropical Medicine and Hygiene |
00029637 |
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34506300 |
Article |
Q1 |
1015 |
4298 |
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137 |
Aditianingsih D., Hidayat J., Ginting V.M. |
56312263600;57221444286;57377973500; |
Comparison of bioimpedance versus pulse contour analysis for intraoperative cardiac index monitoring in patients undergoing kidney transplantation |
2021 |
Anesthesiology and Pain Medicine |
11 |
5 |
e117918 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121465922&doi=10.5812%2fAAPM.117918&partnerID=40&md5=cc44c95f4c7c6f8cc3dd0d4b279457ff |
Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Aditianingsih, D., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Hidayat, J., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Ginting, V.M., Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Background: Cardiac index (CI; cardiac output indexed to body surface area) is routinely measured during kidney transplant surgery. Bioimpedance cardiometry is a transthoracic impedance as the non-invasive alternative for hemodynamic monitoring, using semi-invasive uncalibrated pulse wave or contour (UPC) analysis. Objectives: We performed a cross-sectional observational study on 50 kidney transplant patients to compare the CI measurement agreement, concordance rate, and trending ability between bioimpedance and UPC analysis. Methods: For each patient, CI was measured by bioimpedance analysis (ICON™) and UPC analysis (EV1000™) devices at three time points: after induction, during incision, and at reperfusion. The device measurement accuracy was assessed by the bias value, limit of agreement (LoA), and percentage error (PE) using Bland-Altman analyses. Trending ability was assessed by angular bias and polar concordance through four-quadrant and polar plot analyses. Results: From each time point and pooled measurement, the correlation coefficients were 0.267, 0.327, 0.321, and 0.348. BlandAltman analyses showed mean bias values of 1.18, 1.06, 1.48, and 1.30, LoA of-1.35 to 3.72,-1.39 to 3.51,-1.07 to 4.04, and-1.17 to 3.78, and PE of 82.21, 78.50, 68.74, and 74.58%, respectively. Polar plot analyses revealed angular bias values of-10.37º,-15.01º,-18.68º, and-12.62º, with radial LoA of 89.79º, 85.86º, 83.38º, and 87.82º, respectively. The four-quadrant plot concordance rates were 70.77, 67.35, 65.90, and 69.79%. These analyses showed poor agreement, weak concordance, and low trending ability of bioimpedance cardiometry to UPC analysis. Conclusions: Bioimpedance and UPC analysis for CI measurements were not interchangeable in patients undergoing kidney transplant surgery. Cardiac index monitoring using bioimpedance cardiometry during kidney transplantation should be interpreted cautiously because it showed poor reliability due to low accuracy, precision, and trending ability for CI measurement. © 2021, Author(s). |
Cardiac Output; Intraoperative Monitoring; Kidney Transplantation; Pulse Wave Analysis; Transthoracic Impedance |
atracurium besilate; dobutamine; fentanyl; noradrenalin; propofol; sevoflurane; adult; aged; agitation; anesthesia induction; arterial pressure; Article; body mass; bradycardia; cardiac index; cardiopulmonary bypass; central venous pressure; chronic kidney failure; correlation coefficient; cross-sectional study; female; heart arrhythmia; heart output; heart rate; heart stroke volume; hemodynamic monitoring; human; hypertension; intraoperative monitoring; kidney transplantation; major clinical study; male; mean arterial pressure; measurement accuracy; nausea and vomiting; observational study; outcome assessment; pleura effusion; prospective cost; prospective study; pulse oximetry; pulse wave; systolic blood pressure; tachycardia; transesophageal echocardiography; uncalibrated pulse contour |
Kowsar Medical Institute |
22287523 |
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Article |
Q2 |
438 |
11251 |
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142 |
Teja Y., Nareswari I. |
57325017200;57194336586; |
Acupuncture Therapies for Addressing Post Odontectomy Neuropathy |
2021 |
Medical Acupuncture |
33 |
5 |
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358 |
363 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118590707&doi=10.1089%2facu.2020.1472&partnerID=40&md5=28463ebc7dc0a38e9601eb0cf906c286 |
Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, DKI Jakarta, Indonesia; Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Daerah Istimewa Jakarta, Jakarta, Indonesia |
Teja, Y., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, DKI Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Daerah Istimewa Jakarta, Jakarta, Indonesia; Nareswari, I., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, DKI Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Daerah Istimewa Jakarta, Jakarta, Indonesia |
Background: Third-molar extraction is a common oral surgical procedure that can cause complications. Although rare, nerve injuries that result in permanent neuropathy can occur and include a variety of complaints such as sensory disorders, taste-sensation disorders, speech articulation disorders, etc. Acupuncture is one of several nonpharmacologic therapies that has played a role in managing neuropathic lesions and has been proven to produce good results. Case: A 44-year-old woman with postodontectomy neuropathy developed paresthesia, dysarthria, xerostomia, dysgeusia, pain in the gums and lower right jaw, a chewing disorder, and cephalgia. Her numerical rating scale (NRS) results were: lower right gum pain, 3/10; numbness of the tongue, 4/10; and headache, 1/10. A physical examination revealed dysarthria, a decreased sense of sharpness and dullness in the right mandibular nerve branches, decreased right masseter muscle contractions, and tenderness on the right GB 20 point. Electromyography revealed partial functional lesions in the postganglion at the right fifth cranial nerve. She had body acupuncture therapy at GV 20, GB 20, ST 5, ST 6, ST 7, CV 23, LI 4, HT 5, ST 36, LU 7, and KI 6; ear acupuncture at the Parotid and Shenmen points; and treatment with the Tan Balance Method. Results: After 3 consecutive sessions of acupuncture therapy, this patient's symptoms were reduced. Conclusions: Acupuncture was helpful for reducing paresthesia, dysarthria, xerostomia, dysgeusia, gum and lower right jaw pain, a chewing disorder, and cephalgia in this patient with postodontectomy neuropathy. Clinical trials are needed to support the findings in this case. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
acupuncture; dysarthria; dysgeusia; neuropathy; odontectomy; paresthesia |
paracetamol; acupuncture; adult; analgesia; Article; baihui acupoint; case report; clinical article; daying acupoint; dysarthria; dysgeusia; electromyography; female; fengchi acupoint; gingiva pain; hegu acupoint; human; hypesthesia; jaw pain; jiache acupoint; lianquan acupoint; lieque acupoint; mandibular nerve; masseter muscle; mastication; muscle contraction; neuropathy; numeric rating scale; paresthesia; parotid gland; physical examination; postoperative complication; tongli acupoint; tongue; tooth extraction; trigeminal nerve; xerostomia; xiaguan acupoint; zhaohai acupoint; zusanli acupoint |
Mary Ann Liebert Inc. |
19336586 |
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Article |
Q2 |
281 |
15498 |
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143 |
Djaali W., Mihardja H., Viventius Y., Teja Y., Bunawan H.L., Setiawan M., Yunita L. |
57212479564;57195721818;57223088537;57325017200;57324454000;57324269700;57324454100; |
The Role of Acupuncture in Interventional Pain Management |
2021 |
Medical Acupuncture |
33 |
5 |
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329 |
334 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118530798&doi=10.1089%2facu.2021.0004&partnerID=40&md5=7d65d90740d49223d9332a2572c084c0 |
Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia; Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Universitas Negeri Jakarta, East Jakarta, DKI Jakarta, Indonesia; Center for the Development and Application of Traditional Medicine of DKI Jakarta, Jakarta, Indonesia |
Djaali, W., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Universitas Negeri Jakarta, East Jakarta, DKI Jakarta, Indonesia; Mihardja, H., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Center for the Development and Application of Traditional Medicine of DKI Jakarta, Jakarta, Indonesia; Viventius, Y., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Teja, Y., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bunawan, H.L., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiawan, M., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yunita, L., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: Interventional pain management has been recognized over the last couple of decades for treating chronic-pain syndromes. Acupuncture is a nonpharmacologic therapeutic option for pain management and may be an option for different patients with contraindications for interventional pain management. This review explores this options. Method: This limited review examines the role of acupuncture for managing head-and-neck pain and lower-back pain, according to interventional pain management. Conclusions: Acupuncture at various points, corresponding to the stellate ganglion, which is ST 10 Shuitu, and corresponding to the splanchnic nerve and the facet joint of the lumbar vertebra - which are Ex-B2 paravertebra - can be applied for pain management in the head-and-neck area and in the lower-back area. According to various research findings, acupuncture is effective and safe for reducing pain in the head and neck area, as well as in the lower back. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
acupuncture; head-and-neck pain; interventional pain management; lower-back pain |
acupuncture analgesia; headache; human; interventional pain management; intervertebral articulation; low back pain; neck pain; nerve block; neuroanatomy; paraspinal muscle; Review; shuitu acupoint; splanchnic nerve; stellate ganglion; stellate ganglion block |
Mary Ann Liebert Inc. |
19336586 |
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Review |
Q2 |
281 |
15498 |
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145 |
Hansur L., Pawitan J.A. |
57296411600;6508348067; |
The potential of hydroxysafflor yellow a as an adjuvant in covid-19 patients with acute respiratory distress syndrome |
2021 |
International Medical Journal |
28 |
5 |
|
527 |
531 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117118067&partnerID=40&md5=caa56a92d25ef57cc5e5c3533887adf1 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Muhammadiyah Makassar, Makassar, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Hansur, L., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Medicine, Universitas Muhammadiyah Makassar, Makassar, Indonesia; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: To discuss the potential and molecular mechanism of Carthamus tincorius derived hydroxysafflor yellow A (HSYA) as an alternative herbal adjuvant that may regulate various signaling pathways that might be related to the regulatory effects in COVID-19 patients with ALI and ARDS. Methods: We search Web of Science, PubMed, and Scopus using keywords: Carthamus tinctorius, adjuvant, cytokine storm, COVID-19, SARS-Cov-2, acute lung injury (ALI), and Acute Respiratory Distress Syndrome (ARDS), on 11 September 2020, and 18 December 2020. Results and Discussions: In COVID-19 patients, SARS-CoV-2 replication might be associated with hyper induction of pro-in-flammatory cytokine, which is known as a cytokine storm, and may cause acute lung injury (ALI) that leads to Acute Respiratory Distress Syndrome (ARDS). Carthamus tincorius derived HSYA were used in many studies, in vivo in animal models or in vitro in cell lines and showed inhibition of multiple inflammatory pathways that were involved in ALI and ARDS, which might occur in covid-19 patients. HSYA showed pleiotropic effects in regulating cytokine levels. It regulated TNF-α, IL-1β, IL-6, IFN-β, and showed protective effect by blocking TLR4, MyD88, TRIF, IRF3, NF-κB to avoid cytokine storm and prevent tissue damage. HSYA was showed to reduce oxidative stress-mediated damage, and down-regulate inflammatory cytokines. Further, it was relatively safe when studied as an adjuvant in HIV and cancer patients. Conclusion: We supposed that HSYA could be used as an alternative adjuvant in COVID-19 patients with ARDS. However, clinical trials are needed to prove its efficacy in COVID-19 patients with ARDS. © 2021 Japan University of Health Sciences & Japan International Cultural Exchange Foundation. |
Carthamus tinctorius; COVID-19; Cytokine storm; HSYA; SARS-Cov-2 |
adjuvant; curcumin; hydroxysafflor yellow a; interleukin 1beta; interleukin 6; interleukin 8; myeloid differentiation factor 88; natural product; pathogen associated molecular pattern; toll like receptor 4; tumor necrosis factor; unclassified drug; acute lung injury; adult respiratory distress syndrome; antiinflammatory activity; apoptosis; Article; binding affinity; brain ischemia; cancer patient; coronavirus disease 2019; cytokine production; cytokine storm; down regulation; dyspnea; endothelial dysfunction; endothelium cell; enzyme activity; human; Human immunodeficiency virus; immune response; inflammation; lung edema; nonhuman; pleiotropy; protein expression; protein function; reperfusion injury; respiratory failure; Severe acute respiratory syndrome coronavirus 2; signal transduction |
Japan International Cultural Exchange Foundation |
13412051 |
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Article |
Q4 |
183 |
20490 |
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