|
No records
|
|
773 |
Rahman Y., Krisanti R.I.A., Wisnu W., Sitohang I.B.S. |
57225022226;57210797305;57200425452;56734569200; |
The comparison between free thyroxine and thyroid-stimulating hormone levels on melasma severity: A cross-sectional study |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
|
|
426 |
431 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108964003&doi=10.3889%2foamjms.2021.5952&partnerID=40&md5=b495093253a6b484fb6b524298865e4d |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia |
Rahman, Y., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia; Krisanti, R.I.A., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia; Wisnu, W., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia; Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia |
BACKGROUND: Melasma has been suspected to be linked with levels of thyroid hormone. There is no study that explains the association between thyroid hormone levels with melasma severity. AIM: This study aims to find the discrepancies in the levels of thyroid hormone in varying severity of melasma using two different measurement techniques. METHODS: Subjects were chosen consecutively from the dermatology clinic at RSUPN Dr. Cipto Mangunkusumo hospital. Forty-eight patients participated in this study were categorized into mild melasma and moderate-severe melasma based on modified melasma area and severity index (mMASI) and Janus II measurement. RESULTS: Statistically, mMASI measurement showed no significant association between varying melasma severity with levels of thyroid stimulating hormone and free T4 (FT4), p = 0.375 and p = 0.208, respectively. The Janus II examination using polarized light modality has a weak positive correlation with the serum FT4 level (r = 0.3; p = 0.039). Weak correlation was also found between the two measurement strategies, Janus II and mMASI (r = 0.314; p = 0.03). CONCLUSION: There are no significant differences observed in levels of thyroid hormone between subjects with varying degrees of melasma severity. © 2021 Yusnita Rahman, Roro Inge Ade Krisanti, Wismandari Wisnu, Irma Bernadette S. Sitohang. |
Free T4; Janus II facial analysis system; Melasma; Modified melasma area and severity index; Thyroid-stimulating hormone |
thyrotropin; adult; Article; chloasma; clinical article; cross-sectional study; disease severity; female; free thyroxine index; human; male |
Scientific Foundation SPIROSKI |
18579655 |
|
|
Article |
Q3 |
288 |
15252 |
|
|
|
789 |
Rhatomy S., Dilogo I.H. |
57204509883;56161962800; |
Core decompression and biological treatment in osteonecrosis of the hip due to systemic lupus erythematosus, 8-year follow-up: A case report |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
|
|
74 |
79 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107632892&doi=10.3889%2foamjms.2021.5798&partnerID=40&md5=d126812c5dab6196ca3a6f0a5513b86a |
Department of Orthopaedic and Traumatology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Soeradji Tirtonegoro General Hospital, Yogyakarta, Indonesia; Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rhatomy, S., Department of Orthopaedic and Traumatology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Soeradji Tirtonegoro General Hospital, Yogyakarta, Indonesia; Dilogo, I.H., Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Osteonecrosis most commonly affects the femoral head, especially in middle-aged adults. It can be caused by trauma, chronic inflammation, or infection. It leads to collapse of the entire femoral head and culminates with total hip replacement. CASE REPORT: A 29-year-old female with systemic lupus erythematosus (SLE) had a chief complaint of bilateral hip pain. She was diagnosed with early osteonecrosis of the femoral head (FICAT stage II) using magnetic resonance imaging and core decompression surgery was performed using three small diameter (4 mm) drillings and added biological treatment. She was evaluated with a visual analog scale (VAS), Harris hip score (HHS), and plain radiography in the pre-operative stage and post-operative follow-up. RESULTS: Functional outcome at 8-year follow-up showed improvement with significantly decreased VAS (pre-operative: 5, post-operative: 0), significant improvement of HHS from 52.725 points (poor) pre-operative to 92.025 points (excellent) post-operative, and subsided femoral head lesion. CONCLUSIONS: Surgical decompression and biological treatment result in decreased intraosseous pressure and enhanced osteogenesis. It can restrict the SLE disease progression and limit the number of cell death. © 2021 Sholahuddin Rhatomy, Ismail Hadisoebroto Dilogo. |
Avascular necrosis; Core decompression; Hip; Osteonecrosis; Systemic lupus erythematosus |
corticosteroid; adult; antalgic lump; arteriovenous shunt; Article; avascular necrosis; bone development; bone graft; bone necrosis; bone radiography; case report; clinical article; clinical examination; daily life activity; decompression surgery; differential diagnosis; disease exacerbation; female; femoral head; fluoroscopy; follow up; functional outcome; Harris hip score; hip osteoarthritis; hip pain; hip replacement; human; intermittent pain; morphogenesis; nuclear magnetic resonance imaging; ossification; osteogenesis imperfecta; physical examination; preoperative evaluation; range of motion; systemic lupus erythematosus; thigh region; visual analog scale; weight bearing |
Scientific Foundation SPIROSKI |
18579655 |
|
|
Article |
Q3 |
288 |
15252 |
|
|
|
793 |
Sitohang I.B.S., Nelson B., Marissa M., Indriatmi W., Wisnu W. |
56734569200;57222619613;57210795916;57189888041;57200425452; |
Evaluation of modified melasma area and severity index in hyperthyroid patients receiving anti-thyroid drugs |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
B |
|
344 |
349 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107477787&doi=10.3889%2foamjms.2021.6082&partnerID=40&md5=ecf1548d04f6591bb645bfc03792883e |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Metabolic Endocrine Division, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nelson, B., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Marissa, M., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Indriatmi, W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wisnu, W., Department of Internal Medicine, Metabolic Endocrine Division, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND: Melasma is a common hyperpigmentation disorder, which causes brownish discoloration of the face. Despite unclear mechanisms, thyroid hormones were thought to play a role in melasma. AIM: This study aims to determine and compare the clinical improvement of melasma in hyperthyroid patients receiving anti-thyroid drugs. METHODS: An interventional study with a quasi-experimental design (pre-post-intervention study) was conducted at the Internal Medicine Outpatient Clinic and Dermatology and Venereology Outpatient Clinic, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, from July 2019 to March 2020. A comparative analysis was done to compare the modified melasma area and severity index (mMASI) in hyperthyroid patients before and after 12 weeks of anti-thyroid drugs. All subjects did not receive any additional topical therapies for their melasma. The clinical features were evaluated objectively at baseline and 12th-week visit, by mMASI score on different areas of the face (forehead, left-right malar, and chin) and Wood’s lamp examination. RESULTS: All areas showed a decline in mMASI score components (e.g., involvement areas and darkness degree) after 12 weeks of treatment. However, only the malar area showed a significant decline (p < 0.05). Wood’s lamp examination at baseline revealed dermal type melasma on 17 subjects, mixed type on six subjects, and epidermal type on one subject. All types remained unchanged after 12 weeks of treatment. CONCLUSIONS: Our study demonstrated that mMASI score in malar area improved significantly, this might be because malar area included this study were comprised of epidermal, dermal, and mixed type. On the other hand, based on Wood’s lamp examination, all types of melasma remained unchanged after 12 weeks of treatment. © 2021 Irma Bernadette S. Sitohang, Benny Nelson, Melani Marissa, Wresti Indriatmi, Wismandari Wisnu. |
Hyperthyroid; Melasma; Modified melasma area and severity index; Wood’s lamp |
amiodarone; antithyroid agent; octreotide; thiamazole; thyroid hormone; adult; Article; chloasma; clinical article; clinical assessment; clinical feature; dermatology; experimental design; female; follow up; forehead; human; hyperpigmentation; hyperthyroidism; intervention study; male; observational study; outpatient department; prospective study; thyroid disease; thyroid function test; topical treatment; visual analog scale |
Scientific Foundation SPIROSKI |
18579655 |
|
|
Article |
Q3 |
288 |
15252 |
|
|
|
796 |
Pontoh L.A.P., Ismail H.D., Fiolin J., Yausep O.E. |
57192907426;57224810749;57194498274;57200086151; |
Pain following single-bundle versus double-bundle anterior cruciate ligament reconstruction: A systematic review |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
|
|
153 |
162 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107326267&doi=10.3889%2foamjms.2021.5995&partnerID=40&md5=907e110a1eb993238ca4374c25cdcb6a |
Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Fatmawati General Hospital, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Jakarta Knee Orthopaedic Sports Center, Pondok Indah Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Pontoh, L.A.P., Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Fatmawati General Hospital, Jakarta, Indonesia; Ismail, H.D., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Fiolin, J., Jakarta Knee Orthopaedic Sports Center, Pondok Indah Hospital, Jakarta, Indonesia; Yausep, O.E., Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND: Double-bundle (DB) anterior cruciate ligament reconstruction (ACLR) has been known to result in better functional outcomes, joint stability, and lower revision rates compared to single-bundle (SB) ACLR. However, given the increased invasiveness and damage to the surrounding tissue area, it is proposed that it may be associated with increased pain. AIM: This review aims to gather all studies and literature that reported pain as an outcome when comparing SB versus DB ACLR. METHODS: Literature searching was conducted across seven search engines for studies reporting pain as an outcome and comparing SB versus DB ACLR. RESULTS: Eight studies met the eligibility criteria and were included in the study. Overall, the studies show variable findings regarding pain in DB compared to SB ACLR, with the only statistically significant results from two studies indicating that DB ACLR is associated with more pain than SB ACLR. CONCLUSION: Based on the limited evidence available, no conclusions can be made regarding the pain experienced between people receiving either procedure. This constitutes a need for additional studies with increased follow-up time periods, larger sample size, and better study design. © 2021 Ludwig A. P. Pontoh, H. D. Ismail, Jessica Fiolin, Oliver Emmanuel Yausep. |
Anterior cruciate ligament; Double bundle; Pain; Reconstruction; Single bundle |
analgesic agent; anesthetic agent; anesthesia; anterior cruciate ligament injury; anterior cruciate ligament reconstruction; collateral ligament; data analysis; data extraction; follow up; gracilis flap; hamstring muscle; hamstring tendon; human; joint stability; knee ligament; knee meniscus rupture; knee pain; ligament surgery; meta analysis; operation duration; pain; randomized controlled trial (topic); Review; systematic review; tendon graft; visual analog scale |
Scientific Foundation SPIROSKI |
18579655 |
|
|
Review |
Q3 |
288 |
15252 |
|
|
|
No records
|
|
750 |
Amalia R., Bustamam A., Yudantha A.R., Victor A.A. |
57226194312;36815737800;55489644900;57191055282; |
Diabetic retinopathy detection and captioning based on lesion features using deep learning approach |
2021 |
Communications in Mathematical Biology and Neuroscience |
2021 |
|
59 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110864476&doi=10.28919%2fcmbn%2f5832&partnerID=40&md5=e3e95d1370fc8ff4347362007e9add2e |
Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, 16424, Indonesia; Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo National General Hospital, Jakarta Pusat, 10430, Indonesia |
Amalia, R., Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, 16424, Indonesia; Bustamam, A., Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, 16424, Indonesia; Yudantha, A.R., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo National General Hospital, Jakarta Pusat, 10430, Indonesia; Victor, A.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo National General Hospital, Jakarta Pusat, 10430, Indonesia |
Diabetic Retinopathy (DR) can lead to vision loss if the patient does not get effective treatment based on the patient’s condition. Early detection is needed to know what an effective treatment for those patients is. For helping ophthalmologists, DR detection methods using computer-based were developed. Ophthalmologists can use the result of the method as a consideration in diagnosing the class of DR. One of the powerful methods is deep learning. The proposed method uses two deep learning architectures, namely Convolutional Neural Network (CNN) and Recurrent Neural Network (RNN), for DR detection. CNN is used to detect DR lesion features, and RNN is used for captioning based on those lesion features. We used three pre-trained CNN models, including AlexNet, VGGNet and GoogleNet, and used Long Short-Term Memory (LSTM) as RNN models. In the image preprocessing, we applied contrast enhancement using Contrast Limited Adaptive Histogram Equalization (CLAHE) and compared the results with those without CLAHE. We have done the training and testing process with a different proportion of data. The experimental results show that our proposed method can detect the lesion features and generate caption with the highest average accuracy of 96.12% for GoogleNet and LSTM with CLAHE and the proportion 70% training data 30% testing data. © 2021 the author(s). |
Convolutional neural network (CNN); Deep learning; Diabetic retinopathy; Long short-term memory (LSTM) |
|
SCIK Publishing Corporation |
20522541 |
|
|
Article |
Q4 |
189 |
20081 |
|
|
|
784 |
Bustamam A., Sarwinda D., Paradisa R.H., Victor A.A., Yudantha A.R., Siswantining T. |
36815737800;56119401500;57221562575;57191055282;55489644900;57193446800; |
Evaluation of convolutional neural network variants for diagnosis of diabetic retinopathy |
2021 |
Communications in Mathematical Biology and Neuroscience |
2021 |
|
42 |
|
|
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108354325&doi=10.28919%2fcmbn%2f5660&partnerID=40&md5=46f614ba3ad44a65354d6ec3e2b41ab1 |
Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Bustamam, A., Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Sarwinda, D., Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Paradisa, R.H., Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Victor, A.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Yudantha, A.R., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siswantining, T., Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia |
Diabetic Retinopathy (DR) is a long-term complication of Diabetes Mellitus (DM) that impairs vision. This stage occurs in visual impairment and blindness if treated late. DR identified through scanning fundus images. A technique on classifying DR in fundus images is the deep learning approach, one of the methods of implementing machine learning. In this study, the Convolutional Neural Networks (CNN) method applied with the ResNet-50 and DenseNet-121 architectures. The data adopted in this analysis was generated from DIARETDB1, an online database containing fundus images. Then, the pre-processing stage is carried out on the fundus image to improve model performance, such as selected the green channel from the images and inverted it, converted the images into grayscale images, and applied Contrast Limited Adaptive Histogram Equalization (CLAHE) for uniform contrast in the images. The outcome of this research indicates that the ResNet-50 model is better than DenseNet-121 in detecting DR. The most reliable results from the ResNet-50 model's case testing are accuracy, precision, and recall of 95%, 98%, and 96% respectively. © 2021, SCIK Publishing Corporation. All rights reserved. |
Deep learning; Densenet; Diabetic retinopathy; Fundus image; Resnet |
|
SCIK Publishing Corporation |
20522541 |
|
|
Article |
Q4 |
189 |
20081 |
|
|
|
No records
|
|
235 |
Widaty S., Menaldi S.L., Rihatmadja R., Miranda E., Marissa M., Kekalih A., Friska D., Oktarina C., Surya D. |
57208261546;57192918198;56427016700;57208259598;57210795916;55633562200;57202805330;57208263598;57210797458; |
Involvement of non-medical personnel in management of scabies at a boarding school in Indonesia |
2021 |
Southeast Asian Journal of Tropical Medicine and Public Health |
52 |
4 |
|
527 |
537 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119906461&partnerID=40&md5=3b9a6a331f595bc79905a0e28fbc7d70 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Widaty, S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Menaldi, S.L., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Rihatmadja, R., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Miranda, E., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Marissa, M., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Kekalih, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Friska, D., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktarina, C., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Surya, D., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
One of the most common neglected tropical skin diseases in Indonesia is scabies, commonly associated with overcrowding, poor hygiene and poor nutritional status. Boarding schools are at risk of harboring infected populations. As recurrence is common, non-medical personnel need to be involved in management of scabies. This study aimed to investigate how non-medical personnel, in this case, the boarding school teachers, could manage scabies in a boarding school in Indonesia. We trained the teachers using the education module for early scabies detection approach, namely DeSkab program, to be able to identify three major signs of scabies in the students. Impact of this approach was evaluated in 2017 and 2018 at a religious boarding school in Bogor, Indonesia involving 127 and 202 students, consecutively. An education module was given to 16 boarding school teachers expecting them to be able to examine students prior to school admission and before and after mid-semester break. Teachers’ knowledge increased significantly after the training (p <0.001). This knowledge improvement is an important basis for teachers as non-medical personnel to implement independent scabies monitoring process during the educational year to find students with suspected scabies. Those suspected scabies students were directly referred to nearby public health clinic and treated with 5% permethrin and re-treated one week later. Prevalence of scabies decreased from 76% in 2017 to 49% in 2018 in 69 students who can be followed-up in two consecutive years (p-value = 0.014). In conclusion, involvement of non-medical personnel is an essential and effective strategy to improve management of scabies. © 2021, SEAMEO TROPMED Network. All rights reserved. |
Boarding school; DeSkab; Non-medical personnel; Prevention; Scabies |
|
SEAMEO TROPMED Network |
01251562 |
|
|
Article |
Q4 |
214 |
18533 |
|
|
|
334 |
Yasmon A., Agnes A., Febriani R., Kusumaningrum A., Andriansjah, Sudarmono P. |
41462004500;57352939000;57212580873;57211641695;57352939200;6507855437; |
Identification of nontuberculous mycobacteria (Ntm) species isolated from the sputum, skin and soft tissue of patients in Jakarta, Indonesia |
2021 |
Southeast Asian Journal of Tropical Medicine and Public Health |
52 |
5 |
|
644 |
650 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119897125&partnerID=40&md5=fa2f76f9076156267a3d1d05310fb824 |
Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Yasmon, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Agnes, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Febriani, R., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kusumaningrum, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Andriansjah, Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sudarmono, P., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Knowing the species of nontuberculous mycobacteria (NTM) causing disease in a patient population can guide empiric treatment. In this study we aimed to determine the species of NTM causing disease in a selected patient population in Indonesia in order to guide empiric treatment. We retrospectively reviewed the records of all patients treated at 5 hospitals in Jakarta, Indonesia, diagnosed with NTM infection during January 2018-December 2019. The inclusion criterion for study subjects was having a positive test for NTM and the exclusion criterion was having a positive culture for Mycobacterium tuberculosis complex. Study subjects were confirmed to have NTM by a MPT64 rapid test. The species of NTM were identified by DNA sequencing of Mycobacterium 16S rRNA. A total of 15 patients were determined to have NTM at the study institutions during the study period, 53% male. The average age of study subjects was 45 (range: 4-83) years. The NTM positive specimens were obtained from the sputum (n = 5), skin and soft tissue biopsies (n = 5), and lymphoid tissue biopsies (n = 5). Of the 15 study subjects, 8 (53%) had M. abscessus, 5 (33%) had M. intracellulare, 1 (7%) had M. avium and 1 (7%) had M. cookii. Of the 5 NTM isolates from the sputum, 3 isolates were M. abscessus, 1 isolate was M. intracellulare and 1 isolate was M. Cookii. Of the 5 NTM isolates from skin and soft biopsies, 3 isolates were M. abscessus and the other 2 isolates were M. intracellulare. Of the 5 NTM isolates from lymphoid tissue biopsies, 2 isolates were M. abscessus, 2 isolates were M. intracellulare and 1 isolate was M. Avium. In our study, the most common NTIM isolate was M. abscessus. Empiric treatment of NTM in the study population should include coverage of M. abscessus. Further studies with larger numbers of subjects from multiple institutions are needed to determine if these findings hold true for other parts of Indonesia. © 2021, SEAMEO TROPMED Network. All rights reserved. |
Lymphoid; Mycobacterium; NTM; Skin and soft; Sputum |
|
SEAMEO TROPMED Network |
01251562 |
|
|
Article |
Q4 |
214 |
18533 |
|
|
|
No records
|
|
341 |
Rustamadji P., Wiyarta E., Bethania K.A., Kusmardi K. |
55321572200;57221521342;57226320454;56966625300; |
Potential of AKT2 expression as a predictor of lymph-node metastasis in invasive breast carcinoma of no special type |
2021 |
Journal of Pathology and Translational Medicine |
51 |
3 |
|
271 |
278 |
|
3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111106383&doi=10.4132%2fjptm.2021.04.26&partnerID=40&md5=25c257f935b27c34728f8cc05fdeca15 |
Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rustamadji, P., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bethania, K.A., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusmardi, K., Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Invasive breast carcinoma of no special type (IBC-NST) is the most common type of breast cancer and mainly causes regional lymph-node metastasis (LNM). We investigated the potential for AKT2 expression as a predictive biomarker for LNM in IBC-NST. Methods: Forty-eight paraffin blocks containing IBC-NST primary tumors were divided into two groups based on presence or absence of LNM. Age, tumor grade, tumor size, lymphovascular invasion (LVI), and AKT expression were assessed. AKT2 expression was assessed based on immunohistochemical staining, while other data were collected from archives. Results: Multiple logistic regression results showed that AKT2 expression and LVI were significantly associated with LNM (odds ratio [OR], 5.32; 95% confidence interval [CI], 1.42 to 19.93 and OR, 4.46; 95% CI, 1.17 to 16.97, respectively). AKT2 expression was able to discriminate against LNM (area under the receiver operating characteristic, 0.799 ± 0.063; 95% CI, 0.676 to 0.921) at an H-score cutoff of 104.62 (83.3% sensitivity, 62.5% specificity). Conclusions: AKT2 expression has potential as a predictor of LNM in IBC-NST. The H-score cutoff for AKT2 expression can be used as a classification guide in future studies. © 2021 The Korean Society of Pathologists/The Korean Society for Cytopathology. |
AKT2; Breast neoplasms; Immunohistochemistry; Metastasis |
biological marker; protein kinase B beta; adult; aged; Article; breast carcinoma; cancer grading; clinical article; confidence interval; controlled study; female; human; human tissue; immunohistochemistry; lymph vessel metastasis; multivariate logistic regression analysis; odds ratio; predictive value; protein expression; receiver operating characteristic; sensitivity and specificity; tumor invasion; tumor volume |
Seoul National University |
23837837 |
|
|
Article |
Q2 |
684 |
7312 |
|
|
|
No records
|
|
187 |
Utami T.W., Suwartono H., Umami E.A., Mahardika A., Surya R., Nurana L. |
57195720528;57218391609;57353182200;57352623800;56986345100;57352963000; |
Management of ovarian yolk sac tumor in pregnancy in a limited resource setting: Case report |
2021 |
Middle East Journal of Cancer |
12 |
4 |
|
597 |
601 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119909750&doi=10.30476%2fmejc.2021.84039.1195&partnerID=40&md5=272b65775967af66a20f779444cac466 |
Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Utami, T.W., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suwartono, H., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Umami, E.A., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Mahardika, A., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Surya, R., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nurana, L., Obstetrics and Gynecology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Ovarian yolk sac tumor in pregnancy is a very rare case (<5%). The management could be very challenging since studies regarding the disease are very limited. This case report is written in order to report a rare case of yolk sac tumor in pregnancy and its management. A 29-year-old woman with a 16 weeks gestational age (WGA) in her first pregnancy presented in the emergency room with severe lower abdominal pain. Next, she underwent exploratory laparotomy, and a biopsy was performed, which indicated an ovarian yolk sac tumor. The patient was then given neoadjuvant chemotherapy with carboplatin and paclitaxel. The pregnancy resulted in an intrauterine growth restriction (IUGR) baby, delivered on 33 WGA. The baby was delivered through C-section and the mother continued to undergo optimally debulked laparotomy, total hysterectomy, bilateral salphingo-oophorectomy, omentectomy, and rectosigmoid tumor resection. In dealing with a rare case with limited resources, tailor-made management is required. The most ideal treatment may not be performed, but the clinician should be more adaptive for the patient to have a better outcome. © 2021. |
Intrauterine growth restriction; Neoadjuvant chemotherapy; Ovarian yolk sac tumor |
bleomycin; carboplatin; cisplatin; etoposide; Ki 67 antigen; paclitaxel; abdominal pain; abdominal tenderness; adjuvant therapy; adult; Apgar score; Article; bilateral salpingo-oophorectomy; biometry; biopsy; bleeding; body mass; cancer surgery; case report; cesarean section; clinical article; echography; ectopic pregnancy; emergency ward; endometriosis; female; fetus weight; gestational age; human; human experiment; human tissue; hysterectomy; intrauterine growth retardation; laparotomy; liver metastasis; lower abdominal pain; multiple cycle treatment; neoadjuvant chemotherapy; omentectomy; physical examination; pregnancy; pregnant woman; prenatal care; salpingooophorectomy; scoring system; yolk sac tumor |
Shriaz University of Medical Sciences |
20086709 |
|
|
Article |
Q4 |
227 |
17796 |
|
|
