|
No records
|
|
572 |
Runtu F.M.J.G., Ardhia S.H., Lokeswara A.W., Friska D. |
57204110436;57222662640;57200937543;57202805330; |
Shaping effective communication skills in first-year medical students through community diagnosis exercise |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
|
S37 |
S41 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103682708&partnerID=40&md5=53c2f59a400f54bb8e04b8a5a8b7140a |
Undergraduate Student, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Runtu, F.M.J.G., Undergraduate Student, Faculty of Medicine, Universitas Indonesia, Indonesia; Ardhia, S.H., Undergraduate Student, Faculty of Medicine, Universitas Indonesia, Indonesia; Lokeswara, A.W., Undergraduate Student, Faculty of Medicine, Universitas Indonesia, Indonesia; Friska, D., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: The current study aimed to evaluate the impact of students' participation in this community diagnosis (CD) exercise on their competency development. Methods: The CD was performed by 235 first-year students through a home visit to obtain health data through questionnaire and physical examination; the data was analysed using the IBM® SPSS® version 24 statistical analysis software. The impact of CD participation on student skills development was evaluated using a cross sectional questionnaire-based survey using the Likert five-point scale to assess student attitudes. Results: CD exercise was performed by 235 first-year students by collecting data from 373 community residents. Subsequently, survey on effect of CD exercise on student competency responses were collected from 47 students (20%) of the 235 CD participants; the results showed that most agreed that CD enhanced their competence as physicians in all areas. The highest mean (SD) Likert scale score was recorded for the statement, 'CD enhanced effective communication' (4.47 ±} 0.747). A total of 44 (93.6%) respondents supported the continuation of CD, claiming that the activity is a forum through which students can practice interacting with patients. Conclusion: The survey found that effective communication is the skill most established by involvement in CD, and the activity provides a good base for students' self-development as professional physicians. © 2021 Pakistan Medical Association. All rights reserved. |
(JPMA 71: S-37 [Suppl. 2]; 2021); Communication; Community; Diagnosis; Medical education |
adult; communication skill; conference paper; controlled study; exercise; female; health data; home visit; human; Likert scale; major clinical study; male; medical education; medical student; physical examination; questionnaire; resident; software; student attitude; clinical competence; interpersonal communication; Clinical Competence; Communication; Humans; Physical Examination; Students, Medical; Surveys and Questionnaires |
Pakistan Medical Association |
00309982 |
|
33785939 |
Conference Paper |
Q4 |
242 |
17081 |
|
|
|
573 |
Ambarsari C.G., Tambunan T., Pardede S.O., Rahman FarhanH.F., Kadaristiana A. |
57211850895;55338756200;57210394278;57215612971;57214116079; |
Role of dipstick albuminuria in progression of paediatric chronic kidney disease |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
|
S103 |
S106 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103682550&partnerID=40&md5=586bf5c6a6dfb2305e50086dc7cad5ed |
Department of Child Health, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Ambarsari, C.G., Department of Child Health, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Tambunan, T., Department of Child Health, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Pardede, S.O., Department of Child Health, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Rahman, FarhanH.F., Department of Child Health, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Kadaristiana, A., Department of Child Health, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Objective: Renal function of patients with chronic kidney disease (CKD) is typically evaluated by detecting proteinuria because it is a major predictor of CKD progression. In paediatric patients with CKD, urine albumin-Tocreatinine ratio (ACR) is used to detect CKD progression, which is similar to urine protein-To-creatinine ratio (PCR). However, facilities for evaluation of urine ACR and urine PCR may not be widely available. To date, this is the first study that investigated the predictive value of baseline dipstick albuminuria for 1-year and 3-year CKD progression in Indonesian children. We assessed the association between baseline level of dipstick albuminuria and CKD progression in paediatric patients. Methods: This retrospective cohort study was conducted at the Cipto Mangunkusumo Hospital (CMH) involving 43 children with CKD between 2016 and 2019. The patients were followed up for 1 year and 3 years after enrolment. Risk ratios (RR) for 1-year and 3-year CKD progression were calculated using Fisher's exact test. Results: The RR for 1-year CKD progression in children with baseline dipstick albuminuria 2+ was 2.16 (95% CI: 1.13-4.14, p = 0.02), and the corresponding RR for 3-year CKD progression in these children was 1.70 (95% CI: 0.73-3.97, p=0.21). Conclusion: Dipstick albuminuria was not associated with 1-year and 3-year CKD progression in children. © 2021 Pakistan Medical Association. All rights reserved. |
2021); albuminuria; chronic; chronic renal insufficiency; Kidney failure; proteinuria. (JPMA 71: S-103 [Suppl. 2] |
creatinine; albuminuria; child; chronic kidney failure; disease exacerbation; glomerulus filtration rate; human; Indonesia; retrospective study; Albuminuria; Child; Creatinine; Disease Progression; Glomerular Filtration Rate; Humans; Indonesia; Renal Insufficiency, Chronic; Retrospective Studies |
Pakistan Medical Association |
00309982 |
|
33785952 |
Conference Paper |
Q4 |
242 |
17081 |
|
|
|
No records
|
|
45 |
Pontoh L.A., Dilogo I.H., Rahyussalim A.J., Widodo W., Pandapotan Hutapea R.E., Fiolin J. |
57192907426;56161962800;55212166100;57208941551;57344880100;57194498274; |
Evaluation of patellar dimension and Bristol Index in Asian population: An MRI study |
2021 |
Annals of Medicine and Surgery |
72 |
|
103072 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119336941&doi=10.1016%2fj.amsu.2021.103072&partnerID=40&md5=76f21a6d143ef68b4875caad0c2a0bc0 |
Department of Orthopaedic and Traumatology, Fatmawati General Hospital - Faculty of Medicine Universitas Indonesia, Jl. RS Fatmawati no. 4, Jakarta Selatan, 12430, Indonesia; Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital – Faculty of Medicine Universitas Indonesia, Jl. Diponegoro no. 71, Jakarta Pusat, 10430, Indonesia; Department of Orthopaedic and Traumatology, Pasar Rebo General Hospital, Jl. TB Simatupang no. 30, Jakarta Timur, 13760, Indonesia; Jakarta Knee, Shoulder and Orthopaedic Sport Clinic, Pondok Indah Hospital, Jl. Metro Duta Kav UE, Jakarta, 12310, Indonesia |
Pontoh, L.A., Department of Orthopaedic and Traumatology, Fatmawati General Hospital - Faculty of Medicine Universitas Indonesia, Jl. RS Fatmawati no. 4, Jakarta Selatan, 12430, Indonesia; Dilogo, I.H., Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital – Faculty of Medicine Universitas Indonesia, Jl. Diponegoro no. 71, Jakarta Pusat, 10430, Indonesia; Rahyussalim, A.J., Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital – Faculty of Medicine Universitas Indonesia, Jl. Diponegoro no. 71, Jakarta Pusat, 10430, Indonesia; Widodo, W., Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital – Faculty of Medicine Universitas Indonesia, Jl. Diponegoro no. 71, Jakarta Pusat, 10430, Indonesia; Pandapotan Hutapea, R.E., Department of Orthopaedic and Traumatology, Pasar Rebo General Hospital, Jl. TB Simatupang no. 30, Jakarta Timur, 13760, Indonesia; Fiolin, J., Jakarta Knee, Shoulder and Orthopaedic Sport Clinic, Pondok Indah Hospital, Jl. Metro Duta Kav UE, Jakarta, 12310, Indonesia |
Background: Restoration of patellar thickness is pivotal during a total knee arthroplasty (TKA). Several studies showed there are differences in the knee measurements between Asian and Western population. Purpose: This study aims to evaluate the patellar dimension and Bristol Index of patellar width to thickness (BIPWiT) using magnetic resonance imaging (MRI) in Asian population. Study design: This is a descriptive epidemiology study. Methods: 101 MRI scans of young adult patients with normal patellofemoral joint (PFJ) age 17–40 were evaluated from January 2019 to December 2020. Exclusion criteria included patella-femoral pathology and degenerative joint disease. Data of gender, body height and weight were obtained from physical examination, while patella height, width and thickness were obtained using MRI measurement. Descriptive analysis was used to get the mean and standard deviation of patella dimension, whereas correlation between patella thickness with patella width and length were analyzed using Pearson correlation and BIPWiT ratio was obtained by dividing the patellar width and patellar thickness. Results: Mean patellar length was 30.06 ± 2.94 (29.48–30.64); patellar width was 44.13 ± 4.44 (43.26–45.01); and patellar thickness was 23.89 ± 2.33 (23.43–24.35). Patellar dimension in male were significantly larger compared to female (P < 0.001). However, there was no difference in cartilage thickness between male and female (P = 0.305). There was strong correlation between patellar width and patellar thickness (r = 0.66; P < 0.001) with BIPWiT ratio of 1.85 ± 0.15. Conclusion: BIPWiT of 1.8:1 between patellar width and patellar thickness was recommended as a guide for patellar thickness restoration during TKA. There is no difference of patellar dimension between Asian and Western population in a healthy knee. Clinical relevance: The result of BIPWiT ratio found in this study may aid upon pre-operative planning prior TKA for surgeons in order to achieve optimal patellar thickness and avoid patellofemoral problem. What is known about the subject: Currently there are raising concerns about the different sizes of knee measurements between Asian and Western population which will affect techniques during TKA to achieve optimum result. What this study adds to the existing knowledge: This study not only prove that there is no difference between patellar dimension of Asian and Caucasian but also found a similar BIPWiT ratio for patellar resection during TKA with previous literature. Level of evidence: Level III. © 2021 The Authors |
Anthropometric; Bristol index; MRI; Patella thickness; Patella width |
adult; Article; Asian; body height; body mass; body weight; bristol index; clinical assessment; cross-sectional study; descriptive research; female; human; intrarater reliability; major clinical study; male; nuclear magnetic resonance imaging; patellar dimension; patellar thickness; patellofemoral joint; retrospective study; size; thickness; total knee arthroplasty |
Elsevier Ltd |
20490801 |
|
|
Article |
Q3 |
391 |
12334 |
|
|
|
406 |
Kristianto H., Waluyo A., Gayatri D., Yunir E., Blow D. |
56121348500;57211433568;57197786176;36520254800;57192313241; |
Neuromuscular taping treatment of diabetic foot: A concept analysis |
2021 |
Clinica Terapeutica |
72 |
3 |
|
231 |
235 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105531246&doi=10.7417%2fCT.2021.2320&partnerID=40&md5=c143037b6dd7fff4b19b4ba2e89b5b93 |
Department of Medical Surgical Nursing, School of Nursing, Faculty of Medicine, Universitas Brawijaya, Indonesia; Faculty of Nursing, Universitas Indonesia, Indonesia; Faculty of Medicine, Universitas Indonesia, Indonesia; NeuroMuscular Taping Institute, Rome, Italy; Universitas Brawijaya, Indonesia; Universitas, Indonesia |
Kristianto, H., Department of Medical Surgical Nursing, School of Nursing, Faculty of Medicine, Universitas Brawijaya, Indonesia, Faculty of Nursing, Universitas Indonesia, Indonesia, Universitas Brawijaya, Indonesia, Universitas, Indonesia; Waluyo, A., Faculty of Nursing, Universitas Indonesia, Indonesia; Gayatri, D., Faculty of Nursing, Universitas Indonesia, Indonesia; Yunir, E., Faculty of Medicine, Universitas Indonesia, Indonesia; Blow, D., NeuroMuscular Taping Institute, Rome, Italy |
Objective. The definition of neuromuscular taping (NMT) has yet to be clearly analysed as a possible treatment for diabetic foot. Case studies, theoretical analysis and results of existing research may lead to varying perceptions on the definition of NMT and its possible effects on diabetic foot. This article aims to analyse the definition of the NMT concept and furthermore as a basis for future research development on diabetic foot. Methods. The procedure for reference source search include the principal data bases using “neuromuscular taping” and “diabetic foot” keywords for the period of 2010-2019. The concept analysis uses an 8-step approach with the Walker and Avant's method. Results. Analysis of the NMT concept on diabetic foot obtained attributes of elastic tape, skin, pain, edema, injury, sensorimotor, circulation, drainage, relaxation, local, proprioceptive, motion function, strength, contraction, stabilisation, reflex, rehabilitation, care, musculoskeletal, nerve, muscles, tendons, fascia, joints, lymphatic, longitudinal, wrinkles. There were four groups of attributes, namely inflammatory response, vascularity, neuromusculoskeletal function and musculoskeletal system. NMT application benefits for diabetic foot can be attributed to improving walking function, leg position, decreasing pain response, improving body function index, improving leg muscle strength and motor function, increasing range of movement (ROM), maintaining stability of leg joint function, preventing injury, increasing strength and improving position of ankle joints, reducing stiffness, reducing edema and helping wound healing processes. Conclusions. NMT is a decompression application of an elastic tape on the skin on the diabetic foot that has the effect of reducing the inflammatory response, improving vascularity and neuromusculoskeletal function. It aims to improve neuromusculoskeletal and lymphatic system functioning due to the presence of wrinkles, indicating dilation, with local effects on the sensorimotor and proprioceptive senses in conditions of care, rehabilitation and injury. Copyright © Società Editrice Universo (SEU) |
Concept analysis; Diabetic foot; Neuromuscular taping; Operational definition |
cerebral palsy; concept analysis; diabetic foot; edema; fascia; hemiplegia; human; hypertension; inflammation; joint function; leg muscle; lymphatic drainage; motor performance; rehabilitation care; Review; systematic review; tendon; wound healing; wrinkle; athletic tape; diabetes mellitus; diabetic foot; edema; physiology; skeletal muscle; walking; Athletic Tape; Diabetes Mellitus; Diabetic Foot; Edema; Humans; Muscle, Skeletal; Walking |
Societa Editrice Universo |
00099074 |
|
33956043 |
Review |
Q3 |
450 |
11019 |
|
|
|
No records
|
|
54 |
Harefa, Wijaya I.P., Muhadi, Rumende C.M., Nasution S.A., Koesnoe S., Marbun M.B., Shatri H. |
57298868100;57193731572;57189615533;14325966300;57189373134;26028015000;57195201827;28767986500; |
The association between 24-h blood pressure variability and major adverse cardiac events (MACE) in hospitalized patients with acute myocardial infarction: a retrospective cohort study |
2021 |
Egyptian Heart Journal |
73 |
1 |
88 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117340121&doi=10.1186%2fs43044-021-00213-1&partnerID=40&md5=c9f1acb17b55e567ab93cb770f13356a |
Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia |
Harefa, Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Wijaya, I.P., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Muhadi, Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Rumende, C.M., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Nasution, S.A., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Koesnoe, S., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Marbun, M.B., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Shatri, H., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia |
Background: Acute myocardial infarction (AMI) is major cardiovascular disease that causes high morbidity and mortality. In AMI, ischemia and necrosis affected some cardiomyocytes leading to a decrease in myocardial contractility which is followed by an acute proinflammation reaction and increased sympathetic tone. Meanwhile, high blood pressure variability (BPV) causing an increased left ventricular workload, heart rate, myocardial oxygen demand and induces proinflamations and endothelial dysfunction. Therefore a high BPV and its associated pathological effects are likely to aggravate the physiological function of the heart and affect the emergence of acute cardiac complications in AMI patients. This study aims to investigate the association’s between short-term BPV and major adverse cardiac events (MACE) in AMI patients. This retrospective cohort study used simple random sampling to identify AMI patients who were hospitalized at Cipto Mangunkusumo National Hospital between January 2018 and December 2019. Mann Withney was performed to investigate the association between BPV and MACE. Results: The average systolic BPV value which was calculated as standard deviation (SD) and average real variability (ARV) was higher in the MACE group than in the non-MACE group. Systolic SD and systolic ARV in the MACE group were 13.28 ± 5.41 mmHg and 9.88 ± 3.81 mmHg respectively. In the non-MACE group, systolic SD and systolic ARV were 10.76 (4.59–26.17) mmHg and 8.65 (3.22–19.35) mmHg respectively. There was no significant association between BPV and MACE. However, there were significant differences between systolic SD and systolic ARV in patients with hypertension who experienced MACE and patients without hypertension who experienced MACE. Conclusions: The BPV of AMI patients who experience MACE was higher than that of non-MACE AMI patients. There was no significant association between BPV ​​and MACE during the acute phase of AMI. © 2021, The Author(s). |
Acute myocardial infarction; Average real variability; Blood pressure variability; Major adverse cardiac events |
acute heart infarction; adult; aged; Article; blood pressure monitoring; blood pressure variability; cohort analysis; controlled study; diastolic blood pressure; female; heart function; hospital patient; human; hypertension; major adverse cardiac event; major clinical study; male; retrospective study; systolic blood pressure |
Springer Science and Business Media Deutschland GmbH |
11102608 |
|
|
Article |
Q3 |
212 |
18617 |
|
|
|
78 |
Laurentius A., Mendel B., Prakoso R. |
57213147353;57221914088;57192893243; |
Clinical outcome of renin-angiotensin-aldosterone system blockers in treatment of hypertensive patients with COVID-19: a systematic review and meta-analysis |
2021 |
Egyptian Heart Journal |
73 |
1 |
13 |
|
|
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100576309&doi=10.1186%2fs43044-021-00135-y&partnerID=40&md5=09d9e73f520074123305d8d901cd705f |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pediatric Cardiology and Congenital Heart Defect Division, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Laurentius, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mendel, B., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prakoso, R., Pediatric Cardiology and Congenital Heart Defect Division, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Background: Novel coronavirus disease 2019 has been stated as global disease pandemic due to its rapid spread worldwide. Up to 30% of coronavirus disease 2019 patients with hypertension are more susceptible to death. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers have been used as primary line of medication for hypertension; nonetheless, conflicting data arises as numerous studies showed contradictory results. Main body: Aiming to show clinical outcome of renin-angiotensin-aldosterone system blockers in hospital treatment of hypertensive patients with coronavirus disease 2019, systematically searched literatures through five databases were intensively appraised using The Grading of Recommendations Assessment, Development and Evaluation checklists for cohort studies. Based on the result evaluation from retrospective cohorts involving more than 15,000 patients across Asia and other regions of the world, ten encompassed studies divided into two subgroups in this meta-review showed that in-hospital hypertensive coronavirus disease 2019 patients receiving antihypertensive drugs were associated with overall risk reduction in subgroup 1 (hazard ratio, HR = 0.96, 95% CI = 0.82–1.12) to no outcome association of all-cause mortalities in subgroup 2 (HR = 0.26, 95% CI = 0.19–0.34). All appraised studies in synergism showed that mortality outcomes were not augmented with the employment of either ACE inhibitor or ARB in subjects. Conclusion: Therefore, the results support recommendation by the American Heart Association not to discontinue angiotensin-converting enzyme inhibitor or angiotensin receptor blocker regimens in coronavirus disease 2019 patients with hypertension. © 2021, The Author(s). |
Angiotensin receptor blockers; Angiotensin-converting enzyme inhibitors; COVID-19; Hypertension; Outcome |
angiotensin receptor antagonist; dipeptidyl carboxypeptidase inhibitor; adult; aged; all cause mortality; clinical outcome; confidence interval; coronavirus disease 2019; data base; female; hazard ratio; human; hypertension; hypertensive patient; male; medical society; meta analysis; mortality; renin angiotensin aldosterone system; Review; risk reduction; systematic review |
Springer Science and Business Media Deutschland GmbH |
11102608 |
|
|
Review |
Q3 |
212 |
18617 |
|
|
|
124 |
Bartlett A.W., Sudjaritruk T., Mohamed T.J., Anugulruengkit S., Kumarasamy N., Phongsamart W., Ly P.S., Truong K.H., Van Nguyen L., Do V.C., Ounchanum P., Puthanakit T., Chokephaibulkit K., Lumbiganon P., Kurniati N., Nik Yusoff N.K., Wati D.K., Sohn A.H., Kariminia A. |
56511395900;36538198800;46961185600;57209773680;7003549856;8885235300;9743902800;35811540200;54396225800;56732729400;57200558813;8071686900;7003974471;35564244800;36473260300;6504631866;55816676300;7006405275;6602745222; |
Identification, Management, and Outcomes of Combination Antiretroviral Treatment Failure in Adolescents With Perinatal Human Immunodeficiency Virus Infection in Asia |
2021 |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
73 |
7 |
|
e1919 |
e1926 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118283335&doi=10.1093%2fcid%2fciaa872&partnerID=40&md5=7af8cf47bd95718a30d3277b5797f9ba |
Kirby Institute, University of New South Wales, Sydney, Australia; Department of Pediatrics, Faculty of Medicine, Research Institute for Health Sciences, Chiang Mai UniversityChiang Mai, Thailand; Women and Children Hospital Kuala LumpurKuala Lumpur, Malaysia; Department of Pediatrics, Faculty of Medicine, Chulalongkorn UniversityBangkok, Thailand; Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn UniversityBangkok, Thailand; Chennai Antiviral Research and Treatment Clinical Research Site, VHS-Infectious Diseases Medical Centre, Voluntary Health Services, Chennai, India; Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol UniversityBangkok, Thailand; National Centre for HIV/AIDS, Dermatology and Sexually Transmitted DiseasesPhnom Penh, Cambodia; Children's Hospital 1, Ho Chi Minh City, Viet Nam; National Hospital of PediatricsHanoi, Viet Nam; Children's Hospital 2, Ho Chi Minh City, Viet Nam; Chiangrai Prachanukroh HospitalChiang Rai, Thailand; Department of Pediatrics, Faculty of Medicine, Khon Kaen UniversityKhon Kaen, Thailand; Cipto Mangunkusumo-Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Hospital Raja Perempuan Zainab IIKelantan, Malaysia; Sanglah Hospital, Udayana UniversityBali, Indonesia; TREAT Asia, amfAR-the Foundation for AIDS ResearchBangkok, Thailand |
Bartlett, A.W., Kirby Institute, University of New South Wales, Sydney, Australia; Sudjaritruk, T., Department of Pediatrics, Faculty of Medicine, Research Institute for Health Sciences, Chiang Mai UniversityChiang Mai, Thailand; Mohamed, T.J., Women and Children Hospital Kuala LumpurKuala Lumpur, Malaysia; Anugulruengkit, S., Department of Pediatrics, Faculty of Medicine, Chulalongkorn UniversityBangkok, Thailand, Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn UniversityBangkok, Thailand; Kumarasamy, N., Chennai Antiviral Research and Treatment Clinical Research Site, VHS-Infectious Diseases Medical Centre, Voluntary Health Services, Chennai, India; Phongsamart, W., Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol UniversityBangkok, Thailand; Ly, P.S., National Centre for HIV/AIDS, Dermatology and Sexually Transmitted DiseasesPhnom Penh, Cambodia; Truong, K.H., Children's Hospital 1, Ho Chi Minh City, Viet Nam; Van Nguyen, L., National Hospital of PediatricsHanoi, Viet Nam; Do, V.C., Children's Hospital 2, Ho Chi Minh City, Viet Nam; Ounchanum, P., Chiangrai Prachanukroh HospitalChiang Rai, Thailand; Puthanakit, T., Department of Pediatrics, Faculty of Medicine, Chulalongkorn UniversityBangkok, Thailand, Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn UniversityBangkok, Thailand; Chokephaibulkit, K., Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol UniversityBangkok, Thailand; Lumbiganon, P., Department of Pediatrics, Faculty of Medicine, Khon Kaen UniversityKhon Kaen, Thailand; Kurniati, N., Cipto Mangunkusumo-Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Nik Yusoff, N.K., Hospital Raja Perempuan Zainab IIKelantan, Malaysia; Wati, D.K., Sanglah Hospital, Udayana UniversityBali, Indonesia; Sohn, A.H., TREAT Asia, amfAR-the Foundation for AIDS ResearchBangkok, Thailand; Kariminia, A., Kirby Institute, University of New South Wales, Sydney, Australia |
BACKGROUND: Combination antiretroviral therapy (cART) failure is a major threat to human immunodeficiency virus (HIV) programs, with implications for individual- and population-level outcomes. Adolescents with perinatally acquired HIV infection (PHIVA) should be a focus for treatment failure given their poorer outcomes compared to children and adults. METHODS: Data (2014-2018) from a regional cohort of Asian PHIVA who received at least 6 months of continuous cART were analyzed. Treatment failure was defined according to World Health Organization criteria. Descriptive analyses were used to report treatment failure and subsequent management and evaluate postfailure CD4 count and viral load trends. Kaplan-Meier survival analyses were used to compare the cumulative incidence of death and loss to follow-up (LTFU) by treatment failure status. RESULTS: A total 3196 PHIVA were included in the analysis with a median follow-up period of 3.0 years, of whom 230 (7.2%) had experienced 292 treatment failure events (161 virologic, 128 immunologic, 11 clinical) at a rate of 3.78 per 100 person-years. Of the 292 treatment failure events, 31 (10.6%) had a subsequent cART switch within 6 months, which resulted in better immunologic and virologic outcomes compared to those who did not switch cART. The 5-year cumulative incidence of death and LTFU following treatment failure was 18.5% compared to 10.1% without treatment failure. CONCLUSIONS: Improved implementation of virologic monitoring is required to realize the benefits of virologic determination of cART failure. There is a need to address issues related to accessibility to subsequent cART regimens, poor adherence limiting scope to switch regimens, and the role of antiretroviral resistance testing. © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. |
adolescent; antiretroviral therapy; HIV; treatment failure |
anti human immunodeficiency virus agent; adolescent; adult; Asia; CD4 lymphocyte count; child; female; human; Human immunodeficiency virus infection; pregnancy; treatment failure; virus load; Adolescent; Adult; Anti-HIV Agents; Asia; CD4 Lymphocyte Count; Child; Female; HIV Infections; Humans; Pregnancy; Treatment Failure; Viral Load |
NLM (Medline) |
15376591 |
|
32589711 |
Article |
Q1 |
3440 |
518 |
|
|
|
173 |
Forrat R., Dayan G.H., DiazGranados C.A., Bonaparte M., Laot T., Capeding M.R., Sanchez L., Coronel D.L., Reynales H., Chansinghakul D., Hadinegoro S.R.S., Perroud A.P., Frago C., Zambrano B., Machabert T., Wu Y., Luedtke A., Price B., Vigne C., Haney O., Savarino S.J., Bouckenooghe A., Noriega F. |
36339272700;6701860993;56721307400;56614799700;24471016000;6602161242;57201082261;56418742600;55343075300;29067671300;56893685800;57198777256;56255310300;7801355579;57201364463;57215829074;54395741500;57002517700;57192890936;57215866119;57220410062;18233281300;7005980306; |
Analysis of Hospitalized and Severe Dengue Cases Over the 6 years of Follow-up of the Tetravalent Dengue Vaccine (CYD-TDV) Efficacy Trials in Asia and Latin America |
2021 |
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
73 |
6 |
|
1003 |
1012 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116958578&doi=10.1093%2fcid%2fciab288&partnerID=40&md5=cceec1a946e6b236b138dcb4bb663855 |
Clinical Sciences, Sanofi Pasteur, Marcy l'Etoile, France; Clinical Sciences Sanofi PasteurPA, United States; Translation Sciences and Biomarkers, Sanofi PasteurPA, United States; Global Clinical Science, Sanofi Pasteur, Taguig City, Philippines; Research Institute for Tropical Medicine, Medical Department, Muntinlupa, Philippines; Clinical Sciences, Sanofi PasteurMexico City, Mexico; Centro de Atencion e Investigación Médica, Bogotá, Colombia; Research & Development, Sanofi PasteurBangkok, Thailand; Cipto Mangunkusumo Hospital, University of IndonesiaJakarta, Indonesia; Clinical Sciences, Sanofi Pasteur, São Paulo, Brazil; Clinical Sciences, Sanofi Pasteur, Singapore; Clinical Sciences, Sanofi Pasteur, Uruguay; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Global Pharmacovigilance, Sanofi PasteurPA, United States |
Forrat, R., Clinical Sciences, Sanofi Pasteur, Marcy l'Etoile, France; Dayan, G.H., Clinical Sciences Sanofi PasteurPA, United States; DiazGranados, C.A., Clinical Sciences Sanofi PasteurPA, United States; Bonaparte, M., Translation Sciences and Biomarkers, Sanofi PasteurPA, United States; Laot, T., Global Clinical Science, Sanofi Pasteur, Taguig City, Philippines; Capeding, M.R., Research Institute for Tropical Medicine, Medical Department, Muntinlupa, Philippines; Sanchez, L., Global Clinical Science, Sanofi Pasteur, Taguig City, Philippines; Coronel, D.L., Clinical Sciences, Sanofi PasteurMexico City, Mexico; Reynales, H., Centro de Atencion e Investigación Médica, Bogotá, Colombia; Chansinghakul, D., Research & Development, Sanofi PasteurBangkok, Thailand; Hadinegoro, S.R.S., Cipto Mangunkusumo Hospital, University of IndonesiaJakarta, Indonesia; Perroud, A.P., Clinical Sciences, Sanofi Pasteur, São Paulo, Brazil; Frago, C., Clinical Sciences, Sanofi Pasteur, Singapore; Zambrano, B., Clinical Sciences, Sanofi Pasteur, Uruguay; Machabert, T., Clinical Sciences, Sanofi Pasteur, Marcy l'Etoile, France; Wu, Y., Clinical Sciences Sanofi PasteurPA, United States; Luedtke, A., Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Price, B., Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Vigne, C., Clinical Sciences, Sanofi Pasteur, Marcy l'Etoile, France; Haney, O., Global Pharmacovigilance, Sanofi PasteurPA, United States; Savarino, S.J., Translation Sciences and Biomarkers, Sanofi PasteurPA, United States; Bouckenooghe, A., Clinical Sciences, Sanofi Pasteur, São Paulo, Brazil; Noriega, F., Clinical Sciences Sanofi PasteurPA, United States |
BACKGROUND: CYD-TDV, a live, attenuated, tetravalent dengue vaccine, has been approved for the prevention of symptomatic dengue in previously dengue exposed individuals. This post hoc analysis assessed hospitalized and severe virologically confirmed dengue (VCD) over the complete 6-year follow-up of 3 CYD-TDV efficacy studies (CYD14, CYD15, and CYD23/CYD57). METHODS: The main outcomes were hazard ratios (HRs) for hospitalized or severe VCD by baseline dengue serostatus, focusing on those who were seropositive, and by age at immunization (<9 years/≥9 years). Baseline dengue serostatus was measured or inferred using several methods. Hospitalized VCD cases were characterized in terms of clinical signs and symptoms and wild-type viremia level. Antibody persistence was assessed up to 5 years after the last injection. RESULTS: In those aged ≥9 years and baseline seropositive, CYD-TDV protected against hospitalized and severe VCD over 6 years compared to placebo (HR [95% confidence interval] multiple imputation from month 0 method, .19 [.12-.30] and .15 [.06-.39]; other methods were consistent). Vaccine protection was observed over the different study periods, being highest during the first 2 years. Evidence for a decreased risk of hospitalized and severe VCD was also observed in seropositive participants aged 6-8 years. Clinical signs and symptoms, and quantified dengue viremia from participants with hospitalized VCD were comparable between groups. CONCLUSIONS: CYD-TDV demonstrated robust protection against hospitalized and severe VCD over the entire 6-year follow-up in participants who were seropositive and ≥9 years old. Protection was also observed in seropositive 6-8 year-olds. Clinical Trials Registration: NCT00842530, NCT01983553, NCT01373281, NCT01374516. © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. |
CYD-TDV; dengue; serostatus; VCD |
dengue vaccine; live vaccine; vaccine; virus antibody; Asia; child; controlled study; dengue; Dengue virus; follow up; human; randomized controlled trial; severe dengue; South and Central America; Antibodies, Viral; Asia; Child; Dengue; Dengue Vaccines; Dengue Virus; Follow-Up Studies; Humans; Latin America; Severe Dengue; Vaccines, Attenuated; Vaccines, Combined |
NLM (Medline) |
15376591 |
|
33822015 |
Article |
Q1 |
3440 |
518 |
|
|
|
No records
|
|
898 |
Dewi B.E., Nainggolan L., Sudiro T.M., Chenderawasi S., Goentoro P.L., Sjatha F. |
24076058600;23498394800;6506414225;57221643087;57212515515;55372815000; |
Circulation of various dengue serotypes in a community-based study in Jakarta, Indonesia |
2021 |
Japanese Journal of Infectious Diseases |
74 |
1 |
|
17 |
22 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099705269&doi=10.7883%2fyoken.JJID.2019.431&partnerID=40&md5=d7c98adae43cb2a3728e97343d353000 |
Department of Microbiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Departement of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Community Based Dengue Study, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Cluster of Infectious Diseases and Immunology, Indonesian Medical Education and Research Institute (IMERI), Jakarta, Indonesia |
Dewi, B.E., Department of Microbiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Community Based Dengue Study, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Cluster of Infectious Diseases and Immunology, Indonesian Medical Education and Research Institute (IMERI), Jakarta, Indonesia; Nainggolan, L., Departement of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Community Based Dengue Study, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sudiro, T.M., Department of Microbiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Cluster of Infectious Diseases and Immunology, Indonesian Medical Education and Research Institute (IMERI), Jakarta, Indonesia; Chenderawasi, S., Community Based Dengue Study, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Goentoro, P.L., Community Based Dengue Study, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sjatha, F., Department of Microbiology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Cluster of Infectious Diseases and Immunology, Indonesian Medical Education and Research Institute (IMERI), Jakarta, Indonesia |
Dengue virus (DENV) infection remains to be a serious health problem in Indonesia. Community-based dengue studies to determine circulating DENV serotypes based on the geography and season are limited owing to the expensive cost and significant effort required. Many patients with DENV infection are not hospitalized and many visit the hospital in the later phase of the disease. In this study, we performed active DENV surveillance in a community in Jakarta to study the circulating dengue serotypes; adult febrile patients with fever less than 48 hours were recruited. Disease severity was defined using the World Health Organization (WHO) 1997 guidelines. Rapid NS1 dengue antigen detection was used to screen patients with DENV in the community. Viral culture using the C6/36 cell line, an increased antibody titer on hemagglutination inhibition test and enzyme linked immunosorbent assay, or detection of the viral genome on reverse transcription-polymerase chain reaction was used to confirm DENV infection. Of the 102 patients, 68 (66.7%) were confirmed to have DENV infection, with DENV-2 being the most dominant serotype, followed by DENV-3, DENV-1, and DENV-4, in concordance with several reports of mixed DENV infection. Interestingly, in terms of disease severity, although DENV-3 infection was not the predominant circulating serotype, infection with it tended to cause a more severe disease than infection with DENV-2. © 2021, National Institute of Health. All rights reserved. |
|
DNA polymerase; nonstructural protein 1; viral protein; virus antibody; adult; antibody titer; antigen detection; Article; Dengue virus; disease severity; enzyme linked immunosorbent assay; female; fever; hemagglutination inhibition test; human; human cell; Indonesia; major clinical study; male; monitoring; reverse transcription polymerase chain reaction; serotype; virus culture; virus genome; World Health Organization; adolescent; dengue; Dengue virus; genetics; isolation and purification; middle aged; molecular epidemiology; severity of illness index; virology; young adult; Adolescent; Adult; Antibodies, Viral; Dengue; Dengue Virus; Enzyme-Linked Immunosorbent Assay; Female; Genome, Viral; Humans; Indonesia; Male; Middle Aged; Molecular Epidemiology; Reverse Transcriptase Polymerase Chai |
National Institute of Health |
13446304 |
|
32611971 |
Article |
Q3 |
517 |
9793 |
|
|
