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No records
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146 |
Dwijayanti A., Pawitan J.A. |
55743787900;6508348067; |
Mesenchymal stem cell aging, their environment and methods to restore their quality |
2021 |
International Medical Journal |
28 |
5 |
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520 |
523 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117117062&partnerID=40&md5=e4cc00f4efb942f9321160eff1b790a8 |
Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Dwijayanti, A., Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pawitan, J.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: This article aims to explore the aging of mesenchymal stem cells (MSCs) during cell expansion and available methods to restore their quality. Materials and methods: we searched articles in PubMed/Medline and our library to collect relevant publications of MSC aging, their microenvironment (niche), and various approaches to prevent MSC aging. Results and Discussion: MSC expansion during culture may cause cell aging, which is reflected by change in growth, geno-type, and phenotype that can be seen in morphology and function. There are various approaches that can be used to prevent MSC aging. Approaches to prevent MSC aging in culture can be done by various methods, including by determining donor characteristics, genetic engineering approaches, regulating stem cells microenvironment in vitro, and in vitro physical modification Conclusion: Prevention of MSC aging during culture can be done by selection of MSC sources, genetic modification, and microenvironment and physical adjustments. ©2021 Japan University of Health Sciences & Japan International Cultural Exchange Foundation. |
Aging; Cell culture; Mesenchymal stem cells; Micro environment; Propagation |
adult; article; cell aging; cell culture; DNA modification; genetic engineering; human; human cell; Medline; mesenchymal stem cell; microenvironment; phenotype; stem cell expansion |
Japan International Cultural Exchange Foundation |
13412051 |
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Article |
Q4 |
183 |
20490 |
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162 |
Sylvawani M., Setyohadi B., Purnamasari D., Abdullah M., Kurniawan M.R. |
57225078775;6504721711;36519537700;7103393434;57192808936; |
Comparison of insulin-like growth factor-1 and sclerostin levels between premenopausal women with and without diabetes mellitus |
2021 |
Journal of Taibah University Medical Sciences |
16 |
5 |
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719 |
723 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109109686&doi=10.1016%2fj.jtumed.2021.05.007&partnerID=40&md5=4f913f9e9865492b0cdd9860adfea935 |
Division of Rheumatology, Department of Internal Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Sylvawani, M., Division of Rheumatology, Department of Internal Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Setyohadi, B., Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Purnamasari, D., Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Abdullah, M., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kurniawan, M.R., Division of Rheumatology, Department of Internal Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia |
Objectives: This study assesses the serum levels of insulin-like growth factor-1 (IGF-1) and sclerostin as markers of decreased bone formation in premenopausal women with type 2 diabetes mellitus. Methods: A cross-sectional study was conducted to measure serum levels of IGF-1 and sclerostin in 40 premenopausal women with and without diabetes mellitus using an enzyme-linked immunosorbent assay. The levels of IGF-1 and sclerostin were compared between the groups using the Mann Whitney test and unpaired t-test, respectively. Results: The median IGF-1 serum levels were 40.60 ng/mL and 42.7 ng/mL in the diabetic and non-diabetic groups, respectively, with no significant difference. The serum levels of sclerostin were significantly higher in the diabetic group than in the non-diabetic group (132.1 pg/mL and 96.0 pg/mL, respectively; p < 0.001). Conclusion: The levels of sclerostin were significantly higher in premenopausal women with diabetes mellitus than in the non-diabetic group. Since sclerostin influences the differentiation and maturation of osteoblasts, serum sclerostin might potentially be useful as a marker of decreased bone formation in premenopausal women with diabetes. © 2021 The Authors |
Diabetes mellitus; IGF-1; Osteoblasts; Premenopause; Sclerostin |
alanine aminotransferase; collagen type 1; creatinine; hemoglobin A1c; insulin; oral antidiabetic agent; sclerostin; somatomedin C; adult; aged; Article; body mass; bone metabolism; cell differentiation; cell maturation; civil servant; comparative study; controlled study; cross-sectional study; diabetic patient; enzyme linked immunosorbent assay; estimated glomerular filtration rate; female; housewife; human; major clinical study; non insulin dependent diabetes mellitus; obesity; ossification; osteoblast; premenopause; private sector; protein blood level |
Elsevier B.V. |
16583612 |
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Article |
Q3 |
269 |
15910 |
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164 |
Prasetyono T.O.H. |
26646993900; |
Epinephrine one-per-mil tumescent solution in hand surgery: Review of experimental and clinical studies [Solution tumescente d’épinéphrine à un pour un million en chirurgie de la main: analyse des études expérimentales et cliniques] |
2021 |
Hand Surgery and Rehabilitation |
40 |
5 |
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554 |
559 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106494075&doi=10.1016%2fj.hansur.2021.04.013&partnerID=40&md5=b52780e0e5c85229435baa908f64e6c3 |
Division of Plastic Surgery, Department of Surgery, Cipto Mangunkusumo Hospital/Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; ICTEC (Indonesian Clinical Training and Education Center), Cipto Mangunkusumo Hospital/Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Medical Technology Cluster, IMERI (Indonesian Medical Education and Research Institute), Faculty of Medicine Universitas Indonesia, Education Tower, 2nd Floor, Jl. Salemba Raya No. 6, Jakarta, Indonesia |
Prasetyono, T.O.H., Division of Plastic Surgery, Department of Surgery, Cipto Mangunkusumo Hospital/Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia, ICTEC (Indonesian Clinical Training and Education Center), Cipto Mangunkusumo Hospital/Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia, Medical Technology Cluster, IMERI (Indonesian Medical Education and Research Institute), Faculty of Medicine Universitas Indonesia, Education Tower, 2nd Floor, Jl. Salemba Raya No. 6, Jakarta, Indonesia |
One-per-mil epinephrine solution (1:1,000,000) injected as a tumescent has been used in several hand and upper-limb surgery cases as a substitute for tourniquet. However, reviews of its effectiveness are still lacking. A comprehensive review was conducted based on PubMed, Scopus, Science Direct, Cochrane Library, and Semantic Scholar database search of relevant studies using the keyword “one-per-mil.” Studies not using the exact one-per-mil tumescent solution formula were excluded. The review of clinical studies was conducted according to PRISMA guidelines. Epinephrine and the hydrostatic vasocompressive effect created bloodless operative fields, with 100% experimental flap survival after ischemic insult. The technique was effective in creating bloodless operative fields in 36.3% of varied hand and upper-limb surgery cases and in fully awake surgery. Current studies show that one-per-mil tumescent solution is safe and effective, enabling use of tourniquet to be avoided. © 2021 SFCM |
Epinephrine; Hand injury; Lidocaine; Local anesthesia; Wakefulness |
epinephrine; lidocaine; drug solution; hand injury; health care management; human; hydrostatic pressure; local anesthesia; nonhuman; sex difference; Short Survey; therapy effect |
Elsevier Masson s.r.l. |
24681229 |
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33992818 |
Short Survey |
Q2 |
657 |
7623 |
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166 |
Sitohang I.B.S., Sirait S.A.P., Suryanegara J. |
56734569200;24482203600;57204535485; |
Microneedling in the treatment of atrophic scars: A systematic review of randomised controlled trials |
2021 |
International Wound Journal |
18 |
5 |
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577 |
585 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100333569&doi=10.1111%2fiwj.13559&partnerID=40&md5=53a0daf4a5ed46e9fefa3f5918f68c9b |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sirait, S.A.P., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suryanegara, J., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
To date, treatment of atrophic acne scars remains a therapeutic challenge for dermatologists, yet there is no standard option on the most effective treatment. Microneedling (MN) is a minimally invasive technology that involves repetitive skin puncture using sterile microneedles to disrupt dermal collagen that connects the scar tissue. Recent studies have demonstrated the potency of MN, such as dermaroller and fractionated microneedle radiofrequency, in the treatment of atrophic scars. The objective of this review is to evaluate systematically the current literature on MN for atrophic acne scars. A systematic search of literature was performed from PubMed, Medline, Cochrane Central, and Google Scholar databases for articles published during the last 20 years. Only randomised controlled trials (RCTs) with full-text version of the manuscript available were included in our study. Nine RCTs were included in this review. All treatment modalities demonstrated consistent results that MN was efficacious in treating atrophic acne scars as a monotherapy or in combination with other treatments. Moreover, no serious adverse effects were reported in all studies after MN treatment. MN is a well-tolerated and effective therapeutic modality in treating atrophic acne scars. Further research is required to validate the efficacy of MN with a larger sample size and lengthy follow-up. © 2021 The Authors. International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd. |
atrophic acne scar; microneedling |
acne vulgaris; atrophy; complication; esthetic surgery; human; needle; pathology; randomized controlled trial (topic); scar; treatment outcome; Acne Vulgaris; Atrophy; Cicatrix; Cosmetic Techniques; Humans; Needles; Randomized Controlled Trials as Topic; Treatment Outcome |
John Wiley and Sons Inc |
17424801 |
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33538106 |
Article |
Q1 |
867 |
5385 |
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167 |
Nunan D., Lindblad A., Widyahening I.S., Bernardo W.M., Chi C.-C., Cowdell F., Becker K., Constantine S., East C., Myrhaug H.T., Johnson S.G., Jack E., Thompson R., Achilleos H., Berg R.C., Snibsøer A.K., Puscasiu L., Bartelink M.-L.E.L., Van Peet P.G., Berti F., Tilson J., Tikkinen K.A.O., Albarqouni L., Hoegen P. |
23976859100;56106404200;54893154400;6507335779;8642372600;8608168300;57219926978;57219929038;57219925201;56503684400;57216536721;57204240840;55763226900;57204277188;24721440500;57193017204;25929536400;6701351200;55270285900;7102391287;23490405400;11142330400;57193204115;57219924120; |
Ten papers for teachers of evidence-based medicine and health care: Sicily workshop 2019 |
2021 |
BMJ Evidence-Based Medicine |
26 |
5 |
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224 |
227 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096121852&doi=10.1136%2fbmjebm-2020-111479&partnerID=40&md5=f59cb3d2d628fd79e4b11778bafd8318 |
Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom; Centre for Evidence-Based Medicine, University of Oxford, Oxford, United Kingdom; Alberta College of Family Physicians (PEER), The Department of Family Medicine, University of Alberta, Edmonton, AB, Canada; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil; Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; School of Nursing and Midwifery, Faculty of Health, Education and Life Sciences, Birmingham City University, Birmingham, United Kingdom; Family and Social Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, United States; Internal Medicine, Sapporo Tokushukai Hospital, Sapporo, Japan; School of Nursing and Midwifery and Mercy Health, La Trobe University College of Science Health and Engineering, Bundoora, VIC, Australia; Division for Health Sciences, Norwegian Institute of Public Health, Oslo, Norway; Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Department of Health and Functioning, Faculty of Health and Social Sciences, Western Norway University of Applied Sciences, Bergen, Norway; Yealm Medical Centre, Yealmton, United Kingdom; PenARC (NIHR) Applied Research Collaboration (ARC) South West Peninsula, Exeter, United Kingdom; Office of Medical Education, University of New South Wales, Sydney, NSW, Australia; Paediatrics, Royal London Hospital Barts Health Nhs Trust, London, United Kingdom; Reviews and Health Technology Assessments, Norwegian Institute of Public Health, Oslo, Norway; Health and Caring Sciences, Faculty of Health and Social Sciences, Western Norway University of Applied Sciences, Bergen, Norway; University of Medicine Pharmacy Science and Technology of Targu Mures, Targu Mures, Romania; General Practice, Julius Centre, Umc Utrecht, Utrecht, Netherlands; Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands; Gruppo Italiano per la Medicina Basata Sulle Evidenze (GIMBE), Bologna, Italy; Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, United States; Departments of Urology and Public Health, University of Helsinki, Helsinki University Hospital, Helsinki, Finland; Department of Surgery, South Karelia Central Hospital, Lappeenranta, Finland; Institute for Evidence-Based Healthcare, Faculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD, Australia; School of Health and Social Care, Avans University of Applied Science, Breda, Netherlands |
Nunan, D., Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom, Centre for Evidence-Based Medicine, University of Oxford, Oxford, United Kingdom; Lindblad, A., Alberta College of Family Physicians (PEER), The Department of Family Medicine, University of Alberta, Edmonton, AB, Canada; Widyahening, I.S., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Bernardo, W.M., Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil; Chi, C.-C., Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Cowdell, F., School of Nursing and Midwifery, Faculty of Health, Education and Life Sciences, Birmingham City University, Birmingham, United Kingdom; Becker, K., Family and Social Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, United States; Constantine, S., Internal Medicine, Sapporo Tokushukai Hospital, Sapporo, Japan; East, C., School of Nursing and Midwifery and Mercy Health, La Trobe University College of Science Health and Engineering, Bundoora, VIC, Australia; Myrhaug, H.T., Division for Health Sciences, Norwegian Institute of Public Health, Oslo, Norway, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Johnson, S.G., Department of Health and Functioning, Faculty of Health and Social Sciences, Western Norway University of Applied Sciences, Bergen, Norway; Jack, E., Yealm Medical Centre, Yealmton, United Kingdom, PenARC (NIHR) Applied Research Collaboration (ARC) South West Peninsula, Exeter, United Kingdom; Thompson, R., Office of Medical Education, University of New South Wales, Sydney, NSW, Australia; Achilleos, H., Paediatrics, Royal London Hospital Barts Health Nhs Trust, London, United Kingdom; Berg, R.C., Reviews and Health Technology Assessments, Norwegian Institute of Public Health, Oslo, Norway; Snibsøer, A.K., Health and Caring Sciences, Faculty of Health and Social Sciences, Western Norway University of Applied Sciences, Bergen, Norway; Puscasiu, L., University of Medicine Pharmacy Science and Technology of Targu Mures, Targu Mures, Romania; Bartelink, M.-L.E.L., General Practice, Julius Centre, Umc Utrecht, Utrecht, Netherlands; Van Peet, P.G., Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands; Berti, F., Gruppo Italiano per la Medicina Basata Sulle Evidenze (GIMBE), Bologna, Italy; Tilson, J., Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, United States; Tikkinen, K.A.O., Departments of Urology and Public Health, University of Helsinki, Helsinki University Hospital, Helsinki, Finland, Department of Surgery, South Karelia Central Hospital, Lappeenranta, Finland; Albarqouni, L., Institute for Evidence-Based Healthcare, Faculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD, Australia; Hoegen, P., School of Health and Social Care, Avans University of Applied Science, Breda, Netherlands |
[No abstract available] |
evidence-based practice; health; patient care |
consensus; Delphi study; ethnographic research; evidence based medicine; evidence based practice; health care; health practitioner; human; interview; knowledge management; medical education; patient; patient care; physician; practice guideline; primary medical care; publication; Review; risk factor; risk reduction; shared decision making; Sicily; systematic review (topic); teacher; workshop; health care delivery; Delivery of Health Care; Evidence-Based Medicine; Humans; Sicily |
BMJ Publishing Group |
2515446X |
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33172938 |
Review |
Q2 |
676 |
7397 |
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197 |
Permata T.B.M., Sato H., Gu W., Kakoti S., Uchihara Y., Yoshimatsu Y., Sato I., Kato R., Yamauchi M., Suzuki K., Oike T., Tsushima Y., Gondhowiardjo S., Ohno T., Yasuhara T., Shibata A. |
57197808751;55697961900;57211574572;57197814645;57221723636;57284438600;57285097100;57204087445;8307897300;57376271900;36453136000;57284002500;6508327402;35395665700;56562637100;8323572900; |
High linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells |
2021 |
Journal of Radiation Research |
62 |
5 |
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773 |
781 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115918333&doi=10.1093%2fjrr%2frrab050&partnerID=40&md5=a1550b83230aa8ab90277d2716e9a556 |
Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan; Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Gunma University Heavy IonMedical Center, Gunma, Maebashi, 371-8511, Japan; Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan; Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School OfMedicine, Gunma, Maebashi, 371-8511, Japan; Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School OfMedicine, The University OfTokyo, Bunkyo-ku, Tokyo, 113-8655, Japan; Department of Radiation Biology and Protection, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan; Department of Radiation Medical Science, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan |
Permata, T.B.M., Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan, Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Sato, H., Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan, Gunma University Heavy IonMedical Center, Gunma, Maebashi, 371-8511, Japan; Gu, W., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan, Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School OfMedicine, Gunma, Maebashi, 371-8511, Japan; Kakoti, S., Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan, Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan; Uchihara, Y., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan; Yoshimatsu, Y., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan, Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School OfMedicine, Gunma, Maebashi, 371-8511, Japan; Sato, I., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan; Kato, R., Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School OfMedicine, The University OfTokyo, Bunkyo-ku, Tokyo, 113-8655, Japan; Yamauchi, M., Department of Radiation Biology and Protection, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan; Suzuki, K., Department of Radiation Medical Science, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan; Oike, T., Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan; Tsushima, Y., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan; Gondhowiardjo, S., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Ohno, T., Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan, Gunma University Heavy IonMedical Center, Gunma, Maebashi, 371-8511, Japan; Yasuhara, T., Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School OfMedicine, The University OfTokyo, Bunkyo-ku, Tokyo, 113-8655, Japan; Shibata, A., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan |
Programmed death ligand 1 (PD-L1) expression on the surface of cancer cells affects the efficacy of anti-PD-1/PD-L1 immune checkpoint therapy. However, the mechanism underlying PD-L1 expression in cancer cells is not fully understood, particularly after ionizing radiation (IR). Here, we examined the impact of high linear energy transfer (LET) carbon-ion irradiation on the expression of PD-L1 in human osteosarcoma U2OS cells. We found that the upregulation of PD-L1 expression after high LET carbon-ion irradiation was greater than that induced by X-rays at the same physical and relative biological effectiveness (RBE) dose, and that the upregulation of PD-L1 induced by high LET carbon-ion irradiation was predominantly dependent on ataxia telangiectasia and Rad3-related (ATR) kinase activity. Moreover, we showed that the downstream signaling, e.g. STAT1 phosphorylation and IRF1 expression, was upregulated to a greater extent after high LET carbon-ion irradiation than X-rays, and that IRF1 upregulation was also ATR dependent. Finally, to visualize PD-L1 molecules on the cell surface in 3D, we applied immunofluorescence-based super-resolution imaging. The three-dimensional structured illumination microscopy (3D-SIM) analyses revealed substantial increases in the number of presented PD-L1 molecules on the cell surface after high LET carbon-ion irradiation compared with X-ray irradiation. © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. |
anti-PD-1/PD-L1 therapy; DNA damage response; high linear energy transfer (LET) carbon-ion therapy; PD-L1 expression |
Carbon; Cell membranes; Cytology; Diseases; Ionizing radiation; Ions; Molecules; Oncology; Radiotherapy; Anti-PD-1/programmed death ligand 1 therapy; Carbon ion therapy; Carbon ions; DNA damage response; High linear energy transfer carbon-ion therapy; High linear energy transfers; Human osteosarcoma; Ions irradiation; Programmed death ligand 1 expression; Up-regulation; Energy transfer; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide; ATM protein; ATM protein, human; ATR protein, human; CD274 protein, human; interferon regulatory factor 1; IRF1 protein, human; messenger RNA; morpholine derivative; programmed death 1 ligand 1; pyrazine derivative; pyrone derivative; RNA; STAT1 protein; STAT1 protein, human; sulfone; tumor p |
Oxford University Press |
04493060 |
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34196706 |
Article |
Q2 |
643 |
7838 |
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202 |
Rusdi N.K., Purwaningsih E.H., Hestiantoro A., Elya B., Kusmardi K. |
57211475250;57186723500;8743255100;14014224500;56966625300; |
In vivo antimammary tumor effects of soybean extract with targeted lunasin (ET-Lun) |
2021 |
Pharmacognosy Journal |
13 |
5 |
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1269 |
1276 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115297490&doi=10.5530%2fpj.2021.13.160&partnerID=40&md5=d96a1538654afeda0377ba6b0d8a5e38 |
Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, Indonesia; Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department Obstetrics and Gynaecology, School of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia; Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas INDONESIA, Indonesia |
Rusdi, N.K., Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, Indonesia; Purwaningsih, E.H., Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia; Hestiantoro, A., Department Obstetrics and Gynaecology, School of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Elya, B., Department of Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Kusmardi, K., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia, Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas INDONESIA, Indonesia |
Background/Objective: Lunasin is a peptide, consist of 44 amino acids which have anti-cancer, antioxidant, and anti-inflammatory activity. The price of commercial Lunasin was very expensive due to the high cost of lunasin synthesis and the lack of methods to obtain the pure lunasin weight from plant sources, involving time-consuming analytical instruments. To overcome these problems, the soybean extract with targeted Lunasin (ET-Lun) was made. The aim of this study was to investigate anti-cancer properties of ET-Lun in breast cancer models in vivo. Methods: Effect of ET-Lun was evaluated in 7,12-Dimetilbenz[a]antrasen (DMBA) induced breast cancer rat model. Tumor Mass, volume, and number were measured. The expression of HER2 and EGFR from each treatment group in DMBA-induced rat was evaluated using immunohistochemistry. Results: The results shown that ET-Lun could reduced tumor volume (p=0,021). ET-Lun decreased EGFR expression compared to negative control DMBA (p=0,012). Conclusions: These results indicated that the ET-Lun has anti-breast cancer activity in vivo. © 2021 Phcogj.Com. |
Breast cancer; EGFR; HER2; In-vivo; Soybean |
dimethylbenz[a]anthracene; epidermal growth factor receptor; epidermal growth factor receptor 2; lunasin; peptide; soybean extract; tamoxifen; unclassified drug; aged; animal experiment; animal model; animal tissue; antineoplastic activity; Article; breast cancer; controlled study; female; immunohistochemistry; in vivo study; nonhuman; protein expression; rat; soybean; tumor number; tumor volume |
EManuscript Technologies |
09753575 |
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Article |
Q3 |
268 |
15961 |
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321 |
Kalaij A.G.I., Sugiyanto M., Ilham A.F. |
57223906853;57223907058;57223916865; |
Factors Associated With Vaccination Compliance in Southeast Asian Children: A Systematic Review |
2021 |
Asia-Pacific Journal of Public Health |
33 |
5 |
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479 |
488 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106426931&doi=10.1177%2f10105395211014640&partnerID=40&md5=5913c1adcdd2be2c2d07170aba4e2029 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kalaij, A.G.I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sugiyanto, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ilham, A.F., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Although vaccination coverage has reached a peak of 86% globally, around 19.9 million infants and children are yet to receive routine vaccinations—with Asia holding the highest prevalence of noncompliance. This implies notable gaps in vaccination coverage among some regions in the world. This study aims to analyze the factors associated with compliance toward childhood vaccination in Southeast Asia. A systematic review of observational studies was conducted using the following databases: PubMed, Scopus, and Cochrane. Included studies analyze factors affecting compliance with childhood vaccination in Southeast Asia, and assessed with Joanna Briggs Institute (JBI) and Newcastle-Ottawa Scale’s criteria. Sixteen observational studies were included, with a total of 41 956 subjects, consisting of 15 cross-sectional studies and one case-control study. Our results suggested that parental personal–related, children and family status–related, socioeconomic, and health care–related factors strongly affected subjects’ compliance with immunization. Prominent determinants were older maternal age, higher economics groups, parents in government or health care sectors, and frequent antenatal care visits. On the other hand, noncompliance were associated with younger age, large quantity of family members, lower economic groups, lower education, and unemployed parents. We hope that this comprehensive assessment thoroughly addresses challenges and inform strategies to raise compliance toward childhood vaccination in Southeast Asia. © 2021 APJPH. |
childhood vaccination; compliance; factors; Southeast Asia |
case control study; child; childhood; controlled study; cross-sectional study; education; educational status; female; government; health care cost; human; human experiment; infant; male; maternal age; Medline; Newcastle-Ottawa scale; observational study; prenatal care; review; Scopus; Southeast Asia; Southeast Asian; systematic review; unemployment; vaccination; article |
SAGE Publications Inc. |
10105395 |
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34013786 |
Review |
Q2 |
572 |
8837 |
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322 |
Fuady A., Khoe L.C., Azzahra T.B., Lestari H.M., Sutanto R.L., Yo E.C., Suryoadji K.A., Sudarsono N.C., Findyartini A. |
37085331400;56586245200;57223601523;57223631169;57222060277;57213188908;57223633894;57201862518;56543777300; |
Good Knowledge but Poor Practice Toward COVID-19 Among Indonesian Youth |
2021 |
Asia-Pacific Journal of Public Health |
33 |
5 |
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605 |
607 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105912511&doi=10.1177%2f10105395211015048&partnerID=40&md5=eeb26dde9d980d4470234af3a533b0c1 |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Undergraduate Medical Program, Faculty of Medicine, Indonesia; Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Center for Sports and Exercise Studies, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia; Department of Medical Education, Faculty of Medicine, Indonesia |
Fuady, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Khoe, L.C., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Azzahra, T.B., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Lestari, H.M., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Sutanto, R.L., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Yo, E.C., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Suryoadji, K.A., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Sudarsono, N.C., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Center for Sports and Exercise Studies, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia; Findyartini, A., Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia, Department of Medical Education, Faculty of Medicine, Indonesia |
[No abstract available] |
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SAGE Publications Inc. |
10105395 |
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33998316 |
Article |
Q2 |
572 |
8837 |
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328 |
Sihotang R.C., Alvonico T., Taher A., Birowo P., Rasyid N., Atmoko W. |
57216755881;57216743520;7005269743;6504153311;56245069300;57193125664; |
Premature ejaculation in patients with lower urinary tract symptoms: a systematic review |
2021 |
International Journal of Impotence Research |
33 |
5 |
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516 |
524 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084492871&doi=10.1038%2fs41443-020-0298-5&partnerID=40&md5=243ef2c5fa8e96c70ec2e3eb9ca5b534 |
Faculty of Medicine, Universitas Indonesia, No. 6, Salemba Raya Road, DKI Jakarta, 10430, Indonesia; Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia |
Sihotang, R.C., Faculty of Medicine, Universitas Indonesia, No. 6, Salemba Raya Road, DKI Jakarta, 10430, Indonesia; Alvonico, T., Faculty of Medicine, Universitas Indonesia, No. 6, Salemba Raya Road, DKI Jakarta, 10430, Indonesia; Taher, A., Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia; Birowo, P., Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia; Rasyid, N., Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia; Atmoko, W., Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia |
Lower urinary tract symptoms (LUTS) refer to a group of symptoms related to bladder, prostate, and urethra. LUTS are common in men and the severity increases with age. LUTS are frequently associated with sexual dysfunction, such as premature ejaculation (PE), standing as the most common sexual dysfunction in men. Both LUTS and PE cause distress and dissatisfaction for the patient and his partner. This systematic review aims to determine the relationship between LUTS and PE in men. Two reviewers independently conduct a literature search in five online databases (PubMed, Scopus, Proquest, ClinicalKey, and ScienceDirect). In addition, reviewers also reviewed the reference list of chosen articles to identify additional relevant studies. Twelve articles were included in this systematic review that consists of one cohort study and 11 cross-sectional studies. The total scores of each identified study ranged from “poor” to “good.” The prevalence of PE in LUTS ranged from 12 to 77%. Most of the studies showed a significant relationship between LUTS and PE. PE is more common in older age with the peak prevalence in age of 60–69 years old. There is a possible association between PE and LUTS. Further research using cohort or case-control study design on this topic is needed. © 2020, The Author(s), under exclusive licence to Springer Nature Limited. |
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age; human; International Prostate Symptom Score; male; outcome assessment; premature ejaculation; prevalence; prostatectomy; Review; systematic review; urinary tract infection; aged; case control study; cohort analysis; complication; cross-sectional study; ejaculation; lower urinary tract symptom; middle aged; premature ejaculation; Aged; Case-Control Studies; Cohort Studies; Cross-Sectional Studies; Ejaculation; Humans; Lower Urinary Tract Symptoms; Male; Middle Aged; Premature Ejaculation |
Springer Nature |
09559930 |
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32393845 |
Review |
Q2 |
508 |
9947 |
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