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No records
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791 |
Elhidsi M., Fachrucha F., Irawan R.Y. |
57203157152;57224454767;57224450720; |
N-Acetylcysteine for coronavirus disease-19: A potential adjuvant therapy |
2021 |
Journal of Health Sciences |
11 |
1 |
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1 |
6 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107532673&doi=10.17532%2fjhsci.2020.1156&partnerID=40&md5=54f33bc66788c4c394abb216fff7bce9 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Elhidsi, M., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Fachrucha, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Irawan, R.Y., Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) infection or known as coronavirus disease 2019 (COVID-19) is a highly infectious disease that has been declared as a world pandemic by WHO. Although the majority of patients only experience mild symptoms, older patients and those with comorbidities are in the risk of falling into critically ill and even death. This is thought to correlate with systemic inflammatory response and oxidative stress imbalance. N-acetylcysteine (NAC) is recognized as a potent mucolytic, yet its lesser-known function as an antioxidant is a precursor of glutathione. Basic aspects and either in vivo or in vitro studies showed various mechanisms of NAC acting as a counterbalance in viral infections and its role in decreasing inflammation and oxidative stress. High-dose NAC is reported to be effective as an antioxidant in pneumonia, influenza, sepsis, and acute respiratory distress syndrome. Early evidence in COVID-19 patients showed that NAC could be beneficial. This review gives the scientific background in considering NAC as an adjuvant treatment for COVID-19. © 2021. Mia Elhidsi et al;. All Rights Reserved. |
Antioxidant; coronavirus disease-19; glutathione; N-acetylcysteine; oxidative stress |
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University of Sarajevo - Faculty of Health Studies |
22327576 |
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Article |
Q4 |
112 |
28273 |
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792 |
Marwali E.M., Caesa P., Purnama Y., Rayhan M., Budiwardhana N., Fitria L., Fakhri D., Portman M.A. |
36608535400;57204921746;57225291969;57219904946;56805196100;56500669600;8599513100;7004985824; |
Thiamine levels in Indonesian children with congenital heart diseases undergoing surgery using cardiopulmonary bypass machine |
2021 |
Asian Cardiovascular and Thoracic Annals |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107515265&doi=10.1177%2f02184923211024103&partnerID=40&md5=e04e32d473d0075386f8ced87f6df736 |
Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pediatric Cardiac Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Cardiothoracic Surgery Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Marwali, E.M., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Caesa, P., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Purnama, Y., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Rayhan, M., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Budiwardhana, N., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Fitria, L., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Fakhri, D., Pediatric Cardiac Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Pediatric Cardiac Surgery, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Portman, M.A., Department of Cardiothoracic Surgery Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: This study evaluated thiamine levels in Indonesian children with congenital heart diseases before and after cardiopulmonary bypass and their relationship with clinical and surgical outcomes. Method: A prospective, single center cross-sectional study was conducted to evaluate thiamine levels in 25 children undergoing congenital heart diseases surgery with cardiopulmonary bypass procedure. Thiamine levels were quantified using a high-performance liquid chromatography method. Result: Preoperative thiamine deficiency was observed in one subject. Thiamine levels did not differ statistically between nutritional status and clinical outcomes categories. There were no significant changes in thiamine levels before and after cardiopulmonary bypass (median pre versus post (P25–75): 50 ng/mL (59.00–116.00) and 83.00 ng/mL (70.00–101.00), p = 0.84), although a significant reduction in thiamine levels were observed with longer cardiopulmonary bypass duration (p = 0.017, R = −0.472). Conclusion: Thiamine levels were not significantly impacted by cardiac surgery except in patients undergoing extremely long cardiopulmonary bypass duration. However, clinical outcome was not affected by thiamine levels. © The Author(s) 2021. |
cardiopulmonary bypass; congenital heart disease; malnutrition; Thiamine |
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SAGE Publications Inc. |
02184923 |
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Article |
Q3 |
203 |
19132 |
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793 |
Sitohang I.B.S., Nelson B., Marissa M., Indriatmi W., Wisnu W. |
56734569200;57222619613;57210795916;57189888041;57200425452; |
Evaluation of modified melasma area and severity index in hyperthyroid patients receiving anti-thyroid drugs |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
B |
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344 |
349 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107477787&doi=10.3889%2foamjms.2021.6082&partnerID=40&md5=ecf1548d04f6591bb645bfc03792883e |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Metabolic Endocrine Division, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nelson, B., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Marissa, M., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Indriatmi, W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wisnu, W., Department of Internal Medicine, Metabolic Endocrine Division, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND: Melasma is a common hyperpigmentation disorder, which causes brownish discoloration of the face. Despite unclear mechanisms, thyroid hormones were thought to play a role in melasma. AIM: This study aims to determine and compare the clinical improvement of melasma in hyperthyroid patients receiving anti-thyroid drugs. METHODS: An interventional study with a quasi-experimental design (pre-post-intervention study) was conducted at the Internal Medicine Outpatient Clinic and Dermatology and Venereology Outpatient Clinic, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, from July 2019 to March 2020. A comparative analysis was done to compare the modified melasma area and severity index (mMASI) in hyperthyroid patients before and after 12 weeks of anti-thyroid drugs. All subjects did not receive any additional topical therapies for their melasma. The clinical features were evaluated objectively at baseline and 12th-week visit, by mMASI score on different areas of the face (forehead, left-right malar, and chin) and Wood’s lamp examination. RESULTS: All areas showed a decline in mMASI score components (e.g., involvement areas and darkness degree) after 12 weeks of treatment. However, only the malar area showed a significant decline (p < 0.05). Wood’s lamp examination at baseline revealed dermal type melasma on 17 subjects, mixed type on six subjects, and epidermal type on one subject. All types remained unchanged after 12 weeks of treatment. CONCLUSIONS: Our study demonstrated that mMASI score in malar area improved significantly, this might be because malar area included this study were comprised of epidermal, dermal, and mixed type. On the other hand, based on Wood’s lamp examination, all types of melasma remained unchanged after 12 weeks of treatment. © 2021 Irma Bernadette S. Sitohang, Benny Nelson, Melani Marissa, Wresti Indriatmi, Wismandari Wisnu. |
Hyperthyroid; Melasma; Modified melasma area and severity index; Wood’s lamp |
amiodarone; antithyroid agent; octreotide; thiamazole; thyroid hormone; adult; Article; chloasma; clinical article; clinical assessment; clinical feature; dermatology; experimental design; female; follow up; forehead; human; hyperpigmentation; hyperthyroidism; intervention study; male; observational study; outpatient department; prospective study; thyroid disease; thyroid function test; topical treatment; visual analog scale |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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794 |
Subali A.D., Wiyono L. |
57222071247;57207889054; |
Reverse Transcriptase Loop Mediated Isothermal Amplification (RT-LAMP) for COVID-19 diagnosis: a systematic review and meta-analysis |
2021 |
Pathogens and Global Health |
115 |
5 |
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281 |
291 |
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5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107466709&doi=10.1080%2f20477724.2021.1933335&partnerID=40&md5=bc2cfc39928d141c8b322792377bdf60 |
Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia; Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Subali, A.D., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wiyono, L., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia, Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
COVID-19 pandemic has become a global public health priority. The rapid increase in infection numbers, along with a significant number of deaths, has made the virus a serious threat to human health. Rapid, reliable, and simple diagnostic methods are critical to controlling the disease. While Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) is the current diagnostic gold standard, Reverse Transcriptase Loop-Mediated Isothermal Amplification (RT-LAMP) appears to be a compelling alternative diagnostic test due to its greater simplicity, shorter time to obtain a result, and lower cost. This study examined RT-LAMP application for rapid identification of SARS-CoV-2 infection compared to the RT-PCR assay. A systematic review and meta-analysis was conducted over six scientific databases in accordance with PRISMA guidelines. Original studies published in English conducted on human clinical samples were included. Articles evaluating the sensitivity and specificity of RT-LAMP relative to RT-PCR were considered eligible. Quality assessment of bias and applicability was examined based on QUADAS-2. A total of 351 studies were found based on the keywords and search queries. Fourteen eligible case–control studies fit the mentioned criteria. Quality assessment using QUADAS-2 indicated alow risk of bias for all included studies. All case studies, containing 2,112 samples, had acumulative sensitivity of 95.5% (CI 97.5% = 90.8–97.9%) and cumulative specificity of 99.5% (CI 97.5% = 97.7–99.9%). The RT-LAMP assay could be areliable alternative COVID-19 diagnostic method due to its reduced cost and processing time compared to RT-PCR. RT-LAMP could potentially be utilized during critical high-throughput and high-demand situations. © 2021 Informa UK Limited, trading as Taylor & Francis Group. |
COVID-19; diagnostic test; RT-LAMP; RT-PCR; SARS-CoV-2 |
coronavirus RNA dependent RNA polymerase; coronavirus spike glycoprotein; envelope protein; nonstructural protein 3; nucleocapsid protein; RNA directed DNA polymerase; virus RNA; coronavirus disease 2019; diagnostic test accuracy study; human; limit of detection; meta analysis; nasopharyngeal swab; open reading frame; practice guideline; receiver operating characteristic; reverse transcription loop mediated isothermal amplification; reverse transcription polymerase chain reaction; Review; sensitivity and specificity; Severe acute respiratory syndrome coronavirus 2; systematic review; virus gene; genetics; molecular diagnosis; nucleic acid amplification; pandemic; COVID-19; Humans; Molecular Diagnostic Techniques; Nucleic Acid Amplification Techniques; Pandemics; Reverse Transcriptase Polym |
Taylor and Francis Ltd. |
20477724 |
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34086539 |
Review |
Q1 |
945 |
4761 |
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795 |
Nadhif M.H., Irsyad M., Utomo M.S., Suhaeri M., Whulanza Y. |
57189057498;57220935587;56180933900;56183087500;36807053500; |
Computational Analysis of Soft Polymer Lattices for 3D Wound Dressing Materials |
2021 |
Journal of Mechanical Engineering |
18 |
2 |
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1 |
11 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107456696&partnerID=40&md5=fb3bc81a587f3564de3a190ebd6e1a72 |
Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Indonesia; Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia; Research Center for Metallurgy and Material, Indonesia Institute of Science (LIPI), Indonesia; Indonesia Unit of Education, Research and Training, Universitas Indonesia Hospital, Universitas Indonesia, Indonesia; Department of Mechanical Engineering, Faculty of Engineering Universitas, Indonesia; Research Center on Biomedical Engineering (RCBE), Faculty of Engineering Universitas, Indonesia |
Nadhif, M.H., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia; Irsyad, M., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia; Utomo, M.S., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia; Suhaeri, M., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia, Research Center for Metallurgy and Material, Indonesia Institute of Science (LIPI), Indonesia, Indonesia Unit of Education, Research and Training, Universitas Indonesia Hospital, Universitas Indonesia, Indonesia; Whulanza, Y., Department of Mechanical Engineering, Faculty of Engineering Universitas, Indonesia, Research Center on Biomedical Engineering (RCBE), Faculty of Engineering Universitas, Indonesia |
One of the wound treatments was negative pressure wound therapy (NPWT), which used wound dressings on the wound bed to ameliorate the wound healing. Unfortunately, most wound dressings were two dimensional (2D), lacking the ability to cover severe wounds with a straightforward procedure. The sheets needed to be stacked following the wound curvature, which might be problematic since improper stacking could hinder the wound healing. Regarding the mentioned problems, our group develop 3D wound dressings, which are made using 3D printers. The wound dressings are made of polycaprolactone (PCL), polyurethane (PU), and polyvinyl alcohol (PVA). As the initial stage, the mechanical integrity of the soft polymers was investigated under uniaxial tensile and uniaxial compressive stress using computational methods. The polymers were defined as 3D lattices following the dimension of existing wound dressings. Based on the simulation results of displacement and von Mises stress, the three polymers are mechanically safe to be used as wound dressing materials. © 2021 College of Engineering, Universiti Teknologi MARA (UiTM), Malaysia. All Rights Reserved. |
Computational analysis; Lattice; Soft polymer; Wound dressing |
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UiTM Press |
18235514 |
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Article |
Q3 |
216 |
18402 |
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796 |
Pontoh L.A.P., Ismail H.D., Fiolin J., Yausep O.E. |
57192907426;57224810749;57194498274;57200086151; |
Pain following single-bundle versus double-bundle anterior cruciate ligament reconstruction: A systematic review |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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153 |
162 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107326267&doi=10.3889%2foamjms.2021.5995&partnerID=40&md5=907e110a1eb993238ca4374c25cdcb6a |
Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Fatmawati General Hospital, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Jakarta Knee Orthopaedic Sports Center, Pondok Indah Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Pontoh, L.A.P., Department of Orthopaedic and Traumatology, Faculty of Medicine, Universitas Indonesia, Fatmawati General Hospital, Jakarta, Indonesia; Ismail, H.D., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Fiolin, J., Jakarta Knee Orthopaedic Sports Center, Pondok Indah Hospital, Jakarta, Indonesia; Yausep, O.E., Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND: Double-bundle (DB) anterior cruciate ligament reconstruction (ACLR) has been known to result in better functional outcomes, joint stability, and lower revision rates compared to single-bundle (SB) ACLR. However, given the increased invasiveness and damage to the surrounding tissue area, it is proposed that it may be associated with increased pain. AIM: This review aims to gather all studies and literature that reported pain as an outcome when comparing SB versus DB ACLR. METHODS: Literature searching was conducted across seven search engines for studies reporting pain as an outcome and comparing SB versus DB ACLR. RESULTS: Eight studies met the eligibility criteria and were included in the study. Overall, the studies show variable findings regarding pain in DB compared to SB ACLR, with the only statistically significant results from two studies indicating that DB ACLR is associated with more pain than SB ACLR. CONCLUSION: Based on the limited evidence available, no conclusions can be made regarding the pain experienced between people receiving either procedure. This constitutes a need for additional studies with increased follow-up time periods, larger sample size, and better study design. © 2021 Ludwig A. P. Pontoh, H. D. Ismail, Jessica Fiolin, Oliver Emmanuel Yausep. |
Anterior cruciate ligament; Double bundle; Pain; Reconstruction; Single bundle |
analgesic agent; anesthetic agent; anesthesia; anterior cruciate ligament injury; anterior cruciate ligament reconstruction; collateral ligament; data analysis; data extraction; follow up; gracilis flap; hamstring muscle; hamstring tendon; human; joint stability; knee ligament; knee meniscus rupture; knee pain; ligament surgery; meta analysis; operation duration; pain; randomized controlled trial (topic); Review; systematic review; tendon graft; visual analog scale |
Scientific Foundation SPIROSKI |
18579655 |
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Review |
Q3 |
288 |
15252 |
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797 |
Putri N.M., Tunjung N., Sadikin P.M. |
57192904294;57208446370;56527444500; |
Closure of meningomyelocele defects using various types of keystone-design perforator island flaps |
2021 |
Archives of Plastic Surgery |
48 |
3 |
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261 |
268 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107221892&doi=10.5999%2faps.2020.01326&partnerID=40&md5=aa0494020a0ebeb30f44734693a88382 |
Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Putri, N.M., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tunjung, N., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sadikin, P.M., Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background Various methods have been described to close large meningomyelocele defects, but no technique has been proven superior to others. This study presents cases of meningomyelocele defect closure with a keystone-design perforator island flap. Methods A retrospective study was performed on 14 patients with meningomyelocele defects closed using various types of keystone flaps. Results The median age of the patients at surgery was 10.5 days (range, 1–369 days) and the average defect size was 22.5 cm2 (range, 7.1–55.0 cm2). The average operative time for defect closure was 89.6 minutes (range, 45–120 minutes). Type IV bilateral keystone flaps were used for four defects, type IV unilateral flaps for six defects, type IIA flaps for two defects, and type III flaps for two defects. Conclusions All the defects healed completely with no major complications. The keystonedesign perforator island flap is a reliable, easy, and fast technique to close large meningomyelocele defects. © 2021 The Korean Society of Plastic and Reconstructive Surgeons. |
Island flaps; Meningomyelocele; Perforator flaps; Plastic; Surgery; Surgical flaps |
adult; aged; Article; child; clinical article; clinical outcome; defect size; disease severity; female; human; island flap; keystone design perforator island flap; length of stay; lumbar spine; male; operation duration; perforator flap; plastic surgery; preschool child; retrospective study; thoracolumbar spine; very elderly; wound closure; young adult |
Korean Society of Plastic and Reconstructive Surgeons |
22346163 |
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Article |
Q2 |
509 |
9924 |
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798 |
Rinaldi I., Hamonangan R., Azizi M.S., Cahyanur R., Wirawan F., Fatya A.I., Budiananti A., Winston K. |
23475122400;57194734003;57209578916;37066991400;57205313463;57224164794;57224171532;57224165400; |
Diagnostic value of neutrophil lymphocyte ratio and D-Dimer as biological markers of deep vein thrombosis in patients presenting with unilateral limb edema |
2021 |
Journal of Blood Medicine |
12 |
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313 |
325 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107134090&doi=10.2147%2fJBM.S291226&partnerID=40&md5=e8ea48e2b9ed2ba98d1bdc094dbbe4f7 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Internal Medicine, PGI Cikini Hospital, Jakarta, Indonesia; Division of Cardiology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rinaldi, I., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Hamonangan, R., Department of Internal Medicine, PGI Cikini Hospital, Jakarta, Indonesia; Azizi, M.S., Division of Cardiology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Cahyanur, R., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Wirawan, F., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fatya, A.I., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Budiananti, A., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Winston, K., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Patients with deep vein thrombosis (DVT) pose high morbidity and mortality risk thus needing fast and accurate diagnosis. Wells clinical prediction scores with D-dimer testing are traditionally used to rule out patients with low probability of DVT. However, D-dimer testing has a few limitations regarding its relatively low specificity. Neutrophil-lymphocyte ratio (NLR), a marker of inflammation, was found to increase in DVT. Hence, we aimed to evaluate the role of NLR for DVT diagnosis. Methods: Data were collected from medical records of patients with suspected DVT at Cipto Mangunkusumo National General Hospital during January-December 2014. Diagnosis of DVT was conducted using lower limb ultrasonography. Diagnostic values for NLR, D-dimer, and NLR + D-dimer were determined by receiver operating characteristic (ROC) analysis to obtain area under the curve (AUC), sensitivity, specificity, negative predictive value, and positive predictive values. Sensitivity and specificity analyses of NLR and D-dimer were also conducted based on Wells score and divided into groups of low and high probability of DVT. Results: The AUC values for NLR, D-dimer, and NLR + D-dimer were 72.6%, 70.4%, and 76.1%, respectively. The optimal cut-off value determined for NLR was 5.12 with sensitivity of 67.7%, specificity of 67.9%, PPV of 68.85%, and NPV of 64.91% in differentiating subjects with and without DVT. This study also found that D-dimer had sensitivity of 69.4%, specificity of 71.4%, PPV of 72.88%, and NPV of 67.8%. Meanwhile, the NLR + D-dimer combination had sensitivity of 66.1% and specificity of 72.6%. Multivariate analysis showed that NLR (OR: 2.636; 95% CI: 1.144-6.076; p: 0.023) and D-dimer (OR: 4.175; 95% CI: 1.810-9.633; p: 0.001) were associated with DVT. Conclusion: NLR value has wider AUC than D-Dimer and is relatively easier to obtain and does not require specific assay, thus enabling rapid evaluation of symptomatic patients suspected of having DVT. Adding NLR to D-dimer increased AUC to detect DVT. Therefore, NLR could serve as a complementary diagnostic tool for D-dimer to exclude DVT, especially in low clinical probability patients. © 2021 Rinaldi et al. |
D-dimer; Deep vein thrombosis; Inflammation; Neutrophils lymphocyte ratio; NLR |
biological marker; C reactive protein; D dimer; hemoglobin; adult; Article; atrial fibrillation; cerebrovascular disease; chronic kidney failure; controlled study; deep vein thrombosis; diabetes mellitus; diagnostic test accuracy study; echography; extracellular trap; female; health care facility; heart disease; hematological parameters; human; hypertension; inflammation; internal medicine; lymphocyte count; major clinical study; male; middle aged; nanotechnology; neutrophil lymphocyte ratio; peripheral edema; predictive value; pregnancy; receiver operating characteristic; sensitivity analysis; sensitivity and specificity; venous thromboembolism |
Dove Medical Press Ltd |
11792736 |
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Article |
Q3 |
676 |
7401 |
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799 |
Atmakusuma T.D., Lubis A.M. |
57216961785;56702707800; |
Correlation of serum ferritin and liver iron concentration with transient liver elastography in adult thalassemia intermedia patients with blood transfusion |
2021 |
Journal of Blood Medicine |
12 |
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235 |
243 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107032322&doi=10.2147%2fJBM.S303703&partnerID=40&md5=408d9c4b4409a7ccccfcbc0f6dca1380 |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Lubis, A.M., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: Iron overload is a common feature of thalassemia intermedia due to regular blood transfusion and increased gastrointestinal iron absorption. Early detection and adequate iron chelator can decrease morbidity and mortality from iron overload. Liver iron concentration (LIC) by MRI T2* is the best non-invasive way to measure body iron stores. However, this method is expensive and not available nationwide in Indonesia. The aim of this study was to identify liver iron overload and correlation of transferrin saturation, serum ferritin, liver MRI T2* and LIC with transient liver elastography in adult thalassemia intermedia patients. Methods: This is a cross-sectional study of 45 patients with thalassemia intermedia with blood transfusion and with and without iron chelator therapy. The study was conducted at Cipto Mangunkusumo Hospital from August through October 2016. We performed measurements of transferrin saturation, serum ferritin level, transient liver elastography and liver MRI T2*. Pearson and Spearman correlation tests were used to evaluate the correlation between transient liver elastography with transferrin saturation, serum ferritin, liver MRI T2*and LIC. Results and Discussion: This study showed that 64.4% of study subjects are β-Hb E thalassemia intermedia. Furthermore, 84.4% of study subjects have regular transfusion. Based on liver MRI T2*all subjects suffered from liver iron overload, 48.9% had severe degree. Median value of liver MRI T2* was 1.6 ms. Mean serum ferritin was 2831 ng/mL, with median transferrin saturation of 66%. Mean of LIC corresponding to liver MRI T2* and mean liver stiffness measurement was 15.36±7.37 mg Fe/gr dry weight and 7.7±3.8 kPa, respectively. Liver stiffness correlated with serum ferritin (r=0.651; p=0.000), liver MRI T2* (r=−0.357; p=0.016), and LIC (r=0.433; p=0.003). No correlation was found between liver elastography and transferrin saturation (r=0.204; p=0.178). Conclusion: Serum ferritin, liver MRI T2*and LIC correlated with liver elastography. No correlation was found between transferrin saturation and liver elastography. © 2021 Atmakusuma and Lubis. |
LIC; Liver MRI T2*; Serum ferritin; Thalassemia intermedia; Transient liver elastography |
alanine aminotransferase; aspartate aminotransferase; bilirubin; C reactive protein; deferasirox; deferiprone; hemoglobin; hemoglobin F; iron; iron chelating agent; adult; alpha thalassemia; Article; beta thalassemia; blood sampling; blood transfusion; capillary electrophoresis; clinical article; concentration (parameter); correlation analysis; cross-sectional study; DNA determination; elastography; female; ferritin blood level; hemoglobin E-beta thalassemia; high performance liquid chromatography; human; hypertransaminasemia; iron overload; liver examination; liver function test; liver hemosiderosis; liver stiffness; male; nuclear magnetic resonance imaging; splenectomy; thalassemia intermedia; transferrin saturation |
Dove Medical Press Ltd |
11792736 |
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Article |
Q3 |
676 |
7401 |
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800 |
Harbuwono D.S., Mokoagow M.I., Magfira N., Helda H. |
36056341600;57216673213;57221224711;57195467249; |
ADA Diabetes Risk Test Adaptation in Indonesian Adult Populations: Can It Replace Random Blood Glucose Screening Test? |
2021 |
Journal of Primary Care and Community Health |
12 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106969426&doi=10.1177%2f21501327211021015&partnerID=40&md5=cfd7fedfd14bbf80f4f0f6c421b6a755 |
Faculty of Medicine, Universitas Indonesia, Central Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fatmawati General Hospital, Jakarta, Indonesia; Faculty of Public Health, Universitas Indonesia, Jakarta, Indonesia |
Harbuwono, D.S., Faculty of Medicine, Universitas Indonesia, Central Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mokoagow, M.I., Faculty of Medicine, Universitas Indonesia, Central Jakarta, Indonesia, Fatmawati General Hospital, Jakarta, Indonesia; Magfira, N., Faculty of Public Health, Universitas Indonesia, Jakarta, Indonesia; Helda, H., Faculty of Public Health, Universitas Indonesia, Jakarta, Indonesia |
Aims: The use of non-invasive and easily available assessment tools such as the ADA diabetes risk test is recommended for diabetes screening among general population. This study aims to assess the validity of the ADA diabetes risk test in screening for screening hyperglycemia in Indonesian population. Methods: This cross-sectional study conducted at primary health care in Cibeber sub district at Cilegon city, Banten province, Indonesia. Subjects were aged ≥45 years old without a prior diagnosis of diabetes were recruited consecutively. The risk of hyperglycemia was measured using the ADA Diabetes Risk Test. Random capillary blood glucose (RcBG) with a cut-off value >140 mg/dL used as a comparison. Results: From a total of 134 subjects, 23.13% of subjects (n = 31) had hyperglycemia. The ADA Diabetes Risk Test gave an area under the ROC curve (AUC) of 0.71 (95% CI: 0.60-0.81) with an optimal cut-off of value ≥5. The sensitivity of the ADA diabetes risk test in diagnosing hyperglycemia was 68% with a false-negative rate (FNR) of 32.26%. Meanwhile, at a cut-off value ≥4, the sensitivity of the ADA Diabetes Risk Test was 93% with an FNR of 9.7%. Conclusion: ADA diabetes risk test provides a valuable result as a diabetes screening tool in the Indonesian population, thus promotes intervention strategies for population known to be at risk © The Author(s) 2021. |
ADA diabetes risk test; adult population; hyperglycemia; Indonesia; screening |
adult; cross-sectional study; diabetes mellitus; glucose blood level; human; Indonesia; mass screening; middle aged; sensitivity and specificity; Adult; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus; Humans; Indonesia; Mass Screening; Middle Aged; Sensitivity and Specificity |
SAGE Publications Inc. |
21501319 |
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34053367 |
Article |
Q2 |
550 |
9179 |
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