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67 |
Liem J.F., Mansyur M., Soemarko D.S., Kekalih A., Subekti I., Suyatna F.D., Suryandari D.A., Malik S.G., Pangaribuan B. |
57224169741;37085506800;57192889490;55633562200;24336854300;56039633100;6505763338;7402973374;54785015100; |
Cumulative exposure characteristics of vegetable farmers exposed to Chlorpyrifos in Central Java – Indonesia; a cross-sectional study |
2021 |
BMC Public Health |
21 |
1 |
1066 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107125504&doi=10.1186%2fs12889-021-11161-5&partnerID=40&md5=9fb7a1aa16134c6ee9e3e23e6280115f |
Doctoral Program, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Occupational Health and Safety, Faculty of Medicine and Health Science Universitas Kristen Krida Wacana, Jakarta, 11510, Indonesia; Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Biology, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Jalan Diponegoro No. 69, Kota Jakarta Pusat, Jakarta, Indonesia; Prodia Occupational Health Institute International, Jakarta, 10430, Indonesia |
Liem, J.F., Doctoral Program, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Occupational Health and Safety, Faculty of Medicine and Health Science Universitas Kristen Krida Wacana, Jakarta, 11510, Indonesia; Mansyur, M., Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Soemarko, D.S., Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Kekalih, A., Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Subekti, I., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Suyatna, F.D., Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Suryandari, D.A., Department of Biology, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Malik, S.G., Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Jalan Diponegoro No. 69, Kota Jakarta Pusat, Jakarta, Indonesia; Pangaribuan, B., Prodia Occupational Health Institute International, Jakarta, 10430, Indonesia |
Background: Agriculture is a major economic sector in Indonesia. Chemical pesticides are widely being used in agriculture for controlling pest. There is a growing concern that pesticide exposure, particularly chlorpyrifos (CPF) exposure, combined with other occupational characteristics that determine the level of exposure, can lead to further health impacts for farmers. Our objective was to evaluate the cumulative exposure characteristics among farmers exposed to CPF by using a validated algorithm. Methods: We conducted a cross-sectional study of 152 vegetable farmers aged 18–65 who actively used CPF for at least 1 year in Central Java, Indonesia. Subject characteristics were obtained using a structured interviewer-administered questionnaire, addressed for sociodemographic and work-related characteristics. The cumulative exposure level (CEL) was estimated as a function of the intensity level of pesticide exposure (IL), lifetime years of pesticide use and the number of days spraying per year. CEL was subsequently classified into two groups, high and low exposure groups. The difference in characteristics of the study population was measured using Chi-square, independent-t or Mann-Whitney test. Association between CEL and its characteristics variables were performed by multiple linear regression. Results: Seventy-one subjects (46.7%) were classified as the high exposure group. The use of multiple pesticide mixtures was common among our study population, with 94% of them using 2 or more pesticides. 73% reported direct contact with concentrated pesticides product, and over 80% reported being splashed or spilt during preparation or spraying activity. However, we found that the proportion of proper personal protective equipment (PPE) use in our subjects was low. Higher volume of mixture applied (p < 0.001) and broader acres of land (p = 0.001) were associated with higher cumulative exposure level, while using long-sleeved clothes and long pants (p < 0.05) during pesticide spraying were associated with lower cumulative exposure after adjusted for age and gender. Conclusions: These findings indicate an inadequate knowledge of using pesticides properly. Thus, we recommend comprehensive training on pesticide usage and encourage proper PPE to reduce the exposure level. © 2021, The Author(s). |
Exposure assessment; Exposure reduction; Occupational characteristics; Pesticide cumulative exposure; Work practices |
chlorpyrifos; pesticide; adverse event; agricultural worker; agriculture; cross-sectional study; epidemiology; human; Indonesia; occupational exposure; vegetable; Agriculture; Chlorpyrifos; Cross-Sectional Studies; Farmers; Humans; Indonesia; Occupational Exposure; Pesticides; Vegetables |
BioMed Central Ltd |
14712458 |
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34090393 |
Article |
Q1 |
1230 |
3166 |
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72 |
Fitriana I., Setiati S., Rizal E.W., Istanti R., Rinaldi I., Kojima T., Akishita M., Azwar M.K. |
55486095900;14325991900;57223021639;23496653300;23475122400;55240575700;7004867426;57202798959; |
Malnutrition and depression as predictors for 30-day unplanned readmission in older patient: a prospective cohort study to develop 7-point scoring system |
2021 |
BMC Geriatrics |
21 |
1 |
256 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104539861&doi=10.1186%2fs12877-021-02198-7&partnerID=40&md5=38aa06ca8c7777764cff2096359b93e7 |
Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Clinical Epidemiology and Evidence Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan |
Fitriana, I., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Setiati, S., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia, Clinical Epidemiology and Evidence Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rizal, E.W., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Istanti, R., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia; Rinaldi, I., Clinical Epidemiology and Evidence Based Medicine Unit, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kojima, T., Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Akishita, M., Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Azwar, M.K., Division of Geriatric Medicine, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No.71, Salemba, Jakarta, Indonesia |
Background: Readmission is related to high cost, high burden, and high risk for mortality in geriatric patients. A scoring system can be developed to predict the readmission of older inpatients to perform earlier interventions and prevent readmission. Methods: We followed prospectively inpatients aged 60 years and older for 30 days, with initial comprehensive geriatric assessment (CGA) on admission in a tertiary referral centre. Patients were assessed with CGA tools consisting of FRAIL scale (fatigue, resistance, ambulation, illness, loss of weight), the 15-item Geriatric Depression Scale, Mini Nutritional Assessment short-form (MNA-SF), the Barthel index for activities of daily living (ADL), Charlson Comorbidity Index (CCI), caregiver burden based on 4-item Zarit Burden Index (ZBI), and cognitive problem with Abbreviated Mental Test (AMT). Demographic data, malignancy diagnosis, and number of drugs were also recorded. We excluded data of deceased patients and patients transferred to other hospitals. We conducted stepwise multivariate regression analysis to develop the scoring system. Results: Thirty-day unplanned readmission rate was 37.6 %. Among 266 patients, 64.7 % of them were malnourished, and 46.5 % of them were readmitted. About 24 % were at risk for depression or having depressed mood, and 53.1 % of them were readmitted. In multivariate analysis, nutritional status (OR 2.152, 95 %CI 1.151–4.024), depression status (OR 1.884, 95 %CI 1.071–3.314), malignancy (OR 1.863 95 %CI 1.005–3.451), and functional status (OR 1.584, 95 %CI 0.885–2.835) were included in derivation of 7 score system. The scoring system had maximum score of 7 and incorporated malnutrition (2 points), depression (2 points), malignancy (2 points), and dependent functional status (1 point). A score of 3 or higher suggested 82 % probability of readmission within 30 days following discharge. Area under the curve (AUC) was 0.694 (p = 0.001). Conclusions: Malnutrition, depression, malignancy and functional problem are predictors for 30-day readmission. A practical CGA-based 7 scoring system had moderate accuracy and strong calibration in predicting 30-day unplanned readmission for older patients. © 2021, The Author(s). |
Comprehensive geriatric assessment; Depression; Malnutrition; Predictive score; Readmission |
aged; daily life activity; depression; geriatric assessment; hospital readmission; human; malnutrition; middle aged; nutritional assessment; nutritional status; prospective study; risk factor; Activities of Daily Living; Aged; Depression; Geriatric Assessment; Humans; Malnutrition; Middle Aged; Nutrition Assessment; Nutritional Status; Patient Readmission; Prospective Studies; Risk Factors |
BioMed Central Ltd |
14712318 |
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33865312 |
Article |
Q1 |
1414 |
2506 |
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73 |
Kosasih A., Koepfli C., Dahlan M.S., Hawley W.A., Baird J.K., Mueller I., Lobo N.F., Sutanto I. |
56584346800;26536294400;57195937625;7004280510;15921267800;7006910183;35392948100;6603791639; |
Gametocyte carriage of Plasmodium falciparum (pfs25) and Plasmodium vivax (pvs25) during mass screening and treatment in West Timor, Indonesia: a longitudinal prospective study |
2021 |
Malaria Journal |
20 |
1 |
177 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104141748&doi=10.1186%2fs12936-021-03709-y&partnerID=40&md5=9c099fec0d8bce6347bf112092d4561b |
PhD Programme in Biomedical Sciences, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia; Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; Indonesian Medical Education and Research Institute, Jakarta, Indonesia; Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States; PT Epidemiologi Indonesia, Jakarta, Indonesia; UNICEF, Jakarta, Indonesia; Center for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Infection & Immunity Division, Walter & Eliza Hall Institute, Melbourne, Australia; Department of Parasitology, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia |
Kosasih, A., PhD Programme in Biomedical Sciences, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia, Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, Indonesian Medical Education and Research Institute, Jakarta, Indonesia; Koepfli, C., Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States, Infection & Immunity Division, Walter & Eliza Hall Institute, Melbourne, Australia; Dahlan, M.S., PT Epidemiologi Indonesia, Jakarta, Indonesia; Hawley, W.A., UNICEF, Jakarta, Indonesia; Baird, J.K., Center for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Mueller, I., Infection & Immunity Division, Walter & Eliza Hall Institute, Melbourne, Australia; Lobo, N.F., Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, United States; Sutanto, I., Indonesian Medical Education and Research Institute, Jakarta, Indonesia, Department of Parasitology, Medical Faculty, Universitas Indonesia, Jakarta, Indonesia |
Background: A goal of malaria epidemiological interventions is the detection and treatment of parasite reservoirs in endemic areas—an activity that is expected to reduce local transmission. Since the gametocyte is the only transmissible stage from human host to mosquito vector, this study evaluated the pre and post presence of gametocytes during a mass screening and treatment (MST) intervention conducted during 2013 in East Nusa Tenggara, Indonesia. Methods: RT-qPCR targeting pfs25 and pvs25 transcripts—gametocyte molecular markers for Plasmodium falciparum and Plasmodium vivax, respectively, was performed to detect and quantify gametocytes in blood samples of P. falciparum and P. vivax-infected subjects over the course of the MST study. The presence of both asexual and sexual parasites in microscopic and submicroscopic infections was compared from the start and end of the MST, using proportion tests as well as parametric and non-parametric tests. Results: Parasite prevalence remained unchanged for P. falciparum (6% = 52/811 versus 7% = 50/740, p = 0.838), and decreased slightly for P. vivax (24% = 192/811 versus 19% = 142/740, p = 0.035) between the MST baseline and endpoint. No significant difference was observed in gametocyte prevalence for either P. falciparum (2% = 19/803 versus 3% = 23/729, p = 0.353, OR = 1.34, 95%CI = 0.69–2.63), or P. vivax (7% = 49/744 versus 5% = 39/704, p = 0.442, OR = 0.83, 95%CI = 0.52–1.31). Even though there was an insignificant difference between the two time points, the majority of parasite positive subjects at the endpoint had been negative at baseline (P. falciparum: 66% = 29/44, P. vivax: 60% = 80/134). This was similarly demonstrated for the transmissible stage—where the majority of gametocyte positive subjects at the endpoint were negative at baseline (P. falciparum: 95% = 20/21, P. vivax: 94% = 30/32). These results were independent of treatment provided during MST activities. No difference was demonstrated in parasite and gametocyte density between both time points either in P. falciparum or P. vivax. Conclusion: In this study area, similar prevalence rates of P. falciparum and P. vivax parasites and gametocytes before and after MST, although in different individuals, points to a negligible impact on the parasite reservoir. Treatment administration based on parasite positivity as implemented in the MST should be reevaluated for the elimination strategy in the community. Trial registration Clinical trials registration NCT01878357. Registered 14 June 2013, https://www.clinicaltrials.gov/ct2/show/NCT01878357. © 2021, The Author(s). |
Gametocyte; Mass screening and treatment; Pfs25; Pvs25 |
dihydroartemisinin plus piperaquine; primaquine; adolescent; Article; blood sampling; cell density; controlled study; disease reservoir; endemic disease; female; gametocyte; gene; gene targeting; genetic transcription; human; Indonesia; longitudinal study; major clinical study; malaria falciparum; male; mass screening; microscopy; parasite clearance; parasite transmission; pfs25 gene; Plasmodium vivax malaria; population structure; prevalence; prospective study; pvs25 gene; randomized controlled trial; real time polymerase chain reaction; adult; aged; child; heterozygote; infant; isolation and purification; malaria falciparum; middle aged; parasitology; Plasmodium falciparum; Plasmodium vivax; Plasmodium vivax malaria; preschool child; very elderly; young adult; Adolescent; Adult; Aged; Ag |
BioMed Central Ltd |
14752875 |
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33836772 |
Article |
Q1 |
1718 |
1764 |
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74 |
Darmadi J., Batubara R.R., Himawan S., Azizah N.N., Audah H.K., Arsianti A., Kurniawaty E., Ismail I.S., Batubara I., Audah K.A. |
57222431230;57220745212;57222422725;57191927056;57222432027;36124567000;57214889313;7103005751;26031903000;15119028200; |
Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug |
2021 |
Scientific Reports |
11 |
1 |
6080 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102715983&doi=10.1038%2fs41598-021-85383-3&partnerID=40&md5=0ea6644166c67e4defd273cae7f6aa43 |
Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Drug Development Research Center, IMERI, University of Indonesia, Jakarta, 10430, Indonesia; Department of Medical Chemistry, University of Indonesia, Jakarta, 10430, Indonesia; Faculty of Medicine, University of Lampung, Bandar Lampung, 35145, Indonesia; Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, Malaysia; Biopharmaca Tropica Research Center, IPB University, Bogor, 16680, Indonesia; Department of Chemistry, IPB University, Bogor, 16680, Indonesia; Directorate of Academic Research and Community Service, Swiss German University, Tangerang, 15143, Indonesia |
Darmadi, J., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Batubara, R.R., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Himawan, S., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Azizah, N.N., Drug Development Research Center, IMERI, University of Indonesia, Jakarta, 10430, Indonesia; Audah, H.K., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Arsianti, A., Drug Development Research Center, IMERI, University of Indonesia, Jakarta, 10430, Indonesia, Department of Medical Chemistry, University of Indonesia, Jakarta, 10430, Indonesia; Kurniawaty, E., Faculty of Medicine, University of Lampung, Bandar Lampung, 35145, Indonesia; Ismail, I.S., Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, Malaysia; Batubara, I., Biopharmaca Tropica Research Center, IPB University, Bogor, 16680, Indonesia, Department of Chemistry, IPB University, Bogor, 16680, Indonesia; Audah, K.A., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia, Directorate of Academic Research and Community Service, Swiss German University, Tangerang, 15143, Indonesia |
Local Xylocarpus granatum leaves were extracted by ethyl acetate solvent and characterized by TLC fingerprinting and 2D 1H NMR spectroscopy to contain phenolic compounds as well as several organic and amino acids as metabolic byproducts, such as succinic acid and acetic acid. Traces of flavonoids and other non-categorized phenolic compounds exhibited intermediate antioxidant activity (antioxidant IC50 84.93 ppm) as well as anticancer activity against HeLa, T47D, and HT-29 cell lines; which the latter being most effective against HT-29 with Fraction 5 contained the strongest activity (anticancer IC50 23.12 ppm). Extracts also behaved as a natural growth factor and nonlethal towards brine shrimps as well as human adipose-derived stem cell hADSC due to antioxidative properties. A stability test was performed to examine how storage conditions factored in bioactivity and phytochemical structure. Extracts were compared with several studies about X. granatum leaves extracts to evaluate how ethnogeography and ecosystem factored on biologically active compounds. Further research on anticancer or antioxidant mechanism on cancer cells is needed to determine whether the extract is suitable as a candidate for an anticancer drug. © 2021, The Author(s). |
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acetic acid; antineoplastic agent; plant extract; adipose tissue; animal; Artemia; chemistry; drug screening; HeLa cell line; HT-29 cell line; human; MCF-7 cell line; Meliaceae; metabolism; neoplasm; plant leaf; stem cell; Acetates; Adipose Tissue; Animals; Antineoplastic Agents, Phytogenic; Artemia; Drug Screening Assays, Antitumor; HeLa Cells; HT29 Cells; Humans; MCF-7 Cells; Meliaceae; Neoplasms; Plant Extracts; Plant Leaves; Stem Cells |
Nature Research |
20452322 |
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33727582 |
Article |
Q1 |
1240 |
3130 |
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77 |
Findyartini A., Greviana N., Putera A.M., Sutanto R.L., Saki V.Y., Felaza E. |
56543777300;57197709749;57222064804;57222060277;57222061848;57217487889; |
The relationships between resilience and student personal factors in an undergraduate medical program |
2021 |
BMC Medical Education |
21 |
1 |
113 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101258190&doi=10.1186%2fs12909-021-02547-5&partnerID=40&md5=a9759408209ed0c6e18f2a706196b0ae |
Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Undergraduate Medical Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Findyartini, A., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Greviana, N., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Putera, A.M., Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Undergraduate Medical Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sutanto, R.L., Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Undergraduate Medical Program, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Saki, V.Y., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Felaza, E., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Resilience is an essential aspect of wellbeing that plays a major role in undergraduate medical education. Various personal and social factors are known to affect resilience. Empirical evidence remains limited regarding resilience and the personal factors that affect it among undergraduate medical students in an Asian setting. Therefore, this study aims to identify undergraduate medical students’ level of resilience and its relationships to personal factors in Indonesia. Methods: This cross-sectional study was conducted among undergraduate medical students in years 1–6. Respondents were asked to complete three validated questionnaires: the Connor-Davidson Resilience Scale (CD-RISC) to measure resilience, the Brief-COPE to assess coping mechanisms, and the Big Five Personality Test to measure five personality dimensions. Descriptive and Pearson’s correlation analyses were completed to explore relationships between each variable. Regression analysis was completed to analyze the extent to which coping mechanisms, personality, and academic achievement explained the variation in resilience scores. Results: A total of 1040 respondents completed the questionnaires (a 75.42% response rate). Students in both preclinical and clinical stages had quite good levels of resilience and higher scores on adaptive coping mechanisms than on maladaptive coping mechanisms. Adaptive and maladaptive coping mechanisms, Big Five Personality traits (extraversion, agreeableness, conscientiousness, neuroticism, and openness), and students’ academic achievement explained 46.9% of students’ resilience scores. Conclusions: Although the resilience scores in this study were comparable to resilience scores among undergraduate medical students in other settings, we found that coping mechanisms, personality traits, and academic performance may predict resilience among medical students. © 2021, The Author(s). |
Coping mechanism; Medical students; Personality traits; Resilience; Undergraduate |
cross-sectional study; human; Indonesia; medical education; medical student; personality; Cross-Sectional Studies; Education, Medical, Undergraduate; Humans; Indonesia; Personality; Students, Medical |
BioMed Central Ltd |
14726920 |
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33602176 |
Article |
Q1 |
809 |
5954 |
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82 |
Amanda G., Tafroji W., Sutoyo D.K., Burhan E., Haryanto B., Safari D. |
57193071364;57118271600;6506079672;36058554600;41861500300;23493586700; |
Serotype distribution and antimicrobial profile of Streptococcus pneumoniae isolated from adult patients with community-acquired pneumonia in Jakarta, Indonesia |
2021 |
Journal of Microbiology, Immunology and Infection |
54 |
6 |
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1175 |
1178 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094592942&doi=10.1016%2fj.jmii.2020.10.003&partnerID=40&md5=9c2a2f417f1387a35bf85921e1b795f4 |
Department Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Microbiology, Persahabatan Hospital, Jakarta, Indonesia |
Amanda, G., Department Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Tafroji, W., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Sutoyo, D.K., Department Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Burhan, E., Department Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Haryanto, B., Department of Microbiology, Persahabatan Hospital, Jakarta, Indonesia; Safari, D., Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Streptococcus pneumoniae is one of the primary causes of community-acquired pneumonia. The vaccine serotypes were dominant and could be isolated in 14% of adult patients, with serotype 3 being the most predominant (25%), followed by 6A, 6B, and 7F. Approximately, 44% of the isolates showed resistance to tetracycline. © 2020 |
Antibiotic resistance profile; Community-acquired pneumonia; Serotype; Streptococcus pneumoniae |
antiinfective agent; adolescent; adult; antibiotic resistance; community acquired infection; cross-sectional study; drug effect; female; genetics; human; Indonesia; isolation and purification; male; microbiology; middle aged; pneumonia; serotype; Streptococcus pneumoniae; young adult; Adolescent; Adult; Anti-Bacterial Agents; Community-Acquired Infections; Cross-Sectional Studies; Drug Resistance, Bacterial; Female; Humans; Indonesia; Male; Middle Aged; Pneumonia; Serogroup; Streptococcus pneumoniae; Young Adult |
Elsevier Ltd |
16841182 |
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33268305 |
Article |
Q1 |
1223 |
3210 |
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88 |
Lokeswara A.W., Hiksas R., Irwinda R., Wibowo N. |
57200937543;57226152029;57205713130;15049026900; |
Preeclampsia: From Cellular Wellness to Inappropriate Cell Death, and the Roles of Nutrition |
2021 |
Frontiers in Cell and Developmental Biology |
9 |
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726513 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119532670&doi=10.3389%2ffcell.2021.726513&partnerID=40&md5=38456382efeb541572619e5bed470318 |
Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia |
Lokeswara, A.W., Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Hiksas, R., Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Irwinda, R., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Wibowo, N., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Dr. Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia |
Preeclampsia is one of the most common obstetrical complications worldwide. The pathomechanism of this disease begins with abnormal placentation in early pregnancy, which is associated with inappropriate decidualization, vasculogenesis, angiogenesis, and spiral artery remodeling, leading to endothelial dysfunction. In these processes, appropriate cellular deaths have been proposed to play a pivotal role, including apoptosis and autophagy. The proper functioning of these physiological cell deaths for placentation depends on the wellbeing of the trophoblasts, affected by the structural and functional integrity of each cellular component including the cell membrane, mitochondria, endoplasmic reticulum, genetics, and epigenetics. This cellular wellness, which includes optimal cellular integrity and function, is heavily influenced by nutritional adequacy. In contrast, nutritional deficiencies may result in the alteration of plasma membrane, mitochondrial dysfunction, endoplasmic reticulum stress, and changes in gene expression, DNA methylation, and miRNA expression, as well as weakened defense against environmental contaminants, hence inducing a series of inappropriate cellular deaths such as abnormal apoptosis and necrosis, and autophagy dysfunction and resulting in abnormal trophoblast invasion. Despite their inherent connection, the currently available studies examined the functions of each organelle, the cellular death mechanisms and the nutrition involved, both physiologically in the placenta and in preeclampsia, separately. Therefore, this review aims to comprehensively discuss the relationship between each organelle in maintaining the physiological cell death mechanisms and the nutrition involved, and the interconnection between the disruptions in the cellular organelles and inappropriate cell death mechanisms, resulting in poor trophoblast invasion and differentiation, as seen in preeclampsia. Copyright © 2021 Lokeswara, Hiksas, Irwinda and Wibowo. |
apoptosis; autophagy; cell death; cellular wellness; nutrition; preeclampsia |
aneuploidy; cell death; cell differentiation; cell invasion; cell membrane; cell organelle; endoplasmic reticulum; endoplasmic reticulum stress; environmental factor; epigenetics; gene expression; human; mitochondrion; nonhuman; nutrition; preeclampsia; pregnancy; Review; trophoblast; vascular remodeling |
Frontiers Media S.A. |
2296634X |
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Review |
Q1 |
2452 |
946 |
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114 |
Andrianto, Al-Farabi M.J., Nugraha R.A., Marsudi B.A., Azmi Y. |
57221812919;57210466548;57200701510;57201975146;57200278939; |
Biomarkers of endothelial dysfunction and outcomes in coronavirus disease 2019 (COVID-19) patients: A systematic review and meta-analysis |
2021 |
Microvascular Research |
138 |
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104224 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111341102&doi=10.1016%2fj.mvr.2021.104224&partnerID=40&md5=d5cc3fe2a0d5a70658ecff8ad7fa6f8b |
Department of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia |
Andrianto, Department of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Al-Farabi, M.J., Department of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Nugraha, R.A., Department of Cardiology and Vascular Medicine, Soetomo General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia; Marsudi, B.A., Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Azmi, Y., Faculty of Medicine, Universitas Airlangga, Surabaya, 60286, Indonesia |
Background: Several studies have reported that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can directly infect endothelial cells, and endothelial dysfunction is often found in severe cases of coronavirus disease 2019 (COVID-19). To better understand the prognostic values of endothelial dysfunction in COVID-19-associated coagulopathy, we conducted a systematic review and meta-analysis to assess biomarkers of endothelial cells in patients with COVID-19. Methods: A literature search was conducted on online databases for observational studies evaluating biomarkers of endothelial dysfunction and composite poor outcomes in COVID-19 patients. Results: A total of 1187 patients from 17 studies were included in this analysis. The estimated pooled means for von Willebrand Factor (VWF) antigen levels in COVID-19 patients was higher compared to healthy control (306.42 [95% confidence interval (CI) 291.37–321.48], p < 0.001; I2:86%), with the highest VWF antigen levels was found in deceased COVID-19 patients (448.57 [95% CI 407.20–489.93], p < 0.001; I2:0%). Meta-analysis showed that higher plasma levels of VWF antigen, tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor-1 antigen (PAI-1) antigen, and soluble thrombomodulin (sTM) were associated with composite poor outcome in COVID-19 patients ([standardized mean difference (SMD) 0.74 [0.33–1.16], p < 0.001; I2:80.4%], [SMD 0.55 [0.19–0.92], p = 0.003; I2:6.4%], [SMD 0.33 [0.04–0.62], p = 0.025; I2:7.9%], and [SMD 0.55 [0.10–0.99], p = 0.015; I2:23.6%], respectively). Conclusion: The estimated pooled means show increased levels of VWF antigen in COVID-19 patients. Several biomarkers of endothelial dysfunction, including VFW antigen, t-PA, PAI-1, and sTM, are significantly associated with increased composite poor outcomes in patients with COVID-19. PROSPERO registration number: CRD42021228821 © 2021 Elsevier Inc. |
COVID-19; Endothelial dysfunction; Plasminogen activator inhibitor-1; Thrombomodulin; Tissue-type plasminogen activator; von Willebrand Factor |
biological marker; plasminogen activator inhibitor 1; thrombomodulin; tissue plasminogen activator; von Willebrand factor; biological marker; plasminogen activator inhibitor 1; SERPINE1 protein, human; THBD protein, human; thrombomodulin; tissue plasminogen activator; von Willebrand factor; adult; aged; Article; clinical outcome; controlled study; coronavirus disease 2019; endothelial dysfunction; female; human; major clinical study; male; publication bias; systematic review; blood; diagnosis; meta analysis; metabolism; middle aged; pathophysiology; predictive value; prognosis; therapy; vascular endothelium; very elderly; Adult; Aged; Aged, 80 and over; Biomarkers; COVID-19; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Predictive Value of Tes |
Academic Press Inc. |
00262862 |
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34273359 |
Article |
Q2 |
819 |
5848 |
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155 |
Blom I.M., Campos L.N., El Amine Youcef Ali M., Asyura M.M.A.Z., von Metnitz D.Z., Limann B., Janušonytė E. |
57218125715;57256325100;57257173900;57256325200;57257174000;57257030900;57211896142; |
Youth versus pandemics: the role of future generations in the pandemic treaty |
2021 |
The Lancet Global Health |
9 |
10 |
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e1361 |
e1362 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114832726&doi=10.1016%2fS2214-109X%2821%2900307-7&partnerID=40&md5=8425b6166dd6fbd88fa21d99ef4c5772 |
International Federation of Medical Students' Associations, Nørre Allé 14, Copenhagen, 2200, Denmark; University of Amsterdam, Amsterdam, Netherlands; Faculty of Medical Sciences, Universidade de Pernambuco, Recife, Brazil; Faculty of Medicine, University of Constantine 3, Constantine, Algeria; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sigmund Freud University Vienna, Vienna, Austria; University of Ghana Medical School, Accra, Ghana; Faculty of Medicine, Vilnius University, Vilnius, Lithuania |
Blom, I.M., International Federation of Medical Students' Associations, Nørre Allé 14, Copenhagen, 2200, Denmark, University of Amsterdam, Amsterdam, Netherlands; Campos, L.N., International Federation of Medical Students' Associations, Nørre Allé 14, Copenhagen, 2200, Denmark, Faculty of Medical Sciences, Universidade de Pernambuco, Recife, Brazil; El Amine Youcef Ali, M., International Federation of Medical Students' Associations, Nørre Allé 14, Copenhagen, 2200, Denmark, Faculty of Medicine, University of Constantine 3, Constantine, Algeria; Asyura, M.M.A.Z., International Federation of Medical Students' Associations, Nørre Allé 14, Copenhagen, 2200, Denmark, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; von Metnitz, D.Z., International Federation of Medical Students' Associations, Nørre Allé 14, Copenhagen, 2200, Denmark, Sigmund Freud University Vienna, Vienna, Austria; Limann, B., International Federation of Medical Students' Associations, Nørre Allé 14, Copenhagen, 2200, Denmark, University of Ghana Medical School, Accra, Ghana; Janušonytė, E., International Federation of Medical Students' Associations, Nørre Allé 14, Copenhagen, 2200, Denmark, Faculty of Medicine, Vilnius University, Vilnius, Lithuania |
[No abstract available] |
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awareness; government; health care organization; health care policy; human; leadership; Note; pandemic; public health; work environment; adult; disaster planning; female; global health; legislation and jurisprudence; male; organization and management; pandemic; social responsibility; World Health Organization; young adult; Adult; Disaster Planning; Female; Global Health; Humans; Male; Pandemics; Social Responsibility; World Health Organization; Young Adult |
Elsevier Ltd |
2214109X |
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34331865 |
Note |
Q1 |
7970 |
126 |
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160 |
Yulian E.D., Siregar N.C., Bajuadji |
55983956600;6508087790;57318007000; |
Combination of Simvastatin and FAC Improves Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer |
2021 |
Cancer Research and Treatment |
53 |
4 |
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1072 |
1083 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111269220&doi=10.4143%2fcrt.2020.1024&partnerID=40&md5=fe14ed1b791ebc2592f487892c429602 |
Division of Surgical Oncology, Department of Surgery; Department of Pathology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, Koja General Hospital, Jakarta, Indonesia |
Yulian, E.D., Division of Surgical Oncology, Department of Surgery; Siregar, N.C., Department of Pathology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bajuadji, Department of Surgery, Koja General Hospital, Jakarta, Indonesia |
Purpose The efficacy of neoadjuvant chemotherapy for locally advanced breast cancer (LABC) is limited due to drug resistance and cardiotoxic effects. Preclinical studies have shown that statin induces apoptosis and decreases breast cancer cell growth. This study aims to evaluate the role of statin in combination with fluorouracil, adriamycin, and cyclophosphamide (FAC) therapy in LABC patients. Materials and Methods We undertook a randomized, double-blinded, placebo-controlled trial in two centers of Indonesia. Patients were randomly assigned to FAC plus simvastatin (40 mg/day orally) or FAC plus placebo (40 mg/day) for 21 days. The FAC regimen was repeated every 3 weeks. We evaluated the clinical response, pathological response, and toxicities. Results The objective response rate (ORR) for FAC plus simvastatin was 90% (95% confidence interval [CI], 0.99 to 1.67) by per-protocol analysis. No complete responses (CR) were recorded, but there were 48 partial responses. No significant difference was observed between the two groups with the ORR (p=0.103). The pathological CR rate was 6.25% (2 in simvastatin group and 1 in placebo group). Adverse events in both arms were generally mild, mainly consisted of myotoxicity. Human epidermal growth factor receptor 2 (HER2) expression was a factor related to the success of therapeutic response (odds ratio, 4.2; 95% CI, 1.121 to 15.731; p=0.033). Conclusion This study suggests that simvastatin combined with FAC shows improvements in ORR and pathological response in patients with LABC. Although no statistically significant difference was documented, there was a trend for better activity and tolerability. The addition of 40 mg simvastatin may improve the efficacy of FAC in LABC patients with HER2 overexpression. Copyright 2021by theKoreanCancerAssociation |
Breast neoplasms; FAC; Neoadjuvant therapy; Simvastatin |
creatine kinase; cyclophosphamide; doxorubicin; epidermal growth factor receptor 2; fluorouracil; simvastatin; antineoplastic agent; cyclophosphamide; doxorubicin; epidermal growth factor receptor 2; ERBB2 protein, human; fluorouracil; simvastatin; adjuvant therapy; adult; advanced breast cancer; aged; alopecia; anemia; Article; blood toxicity; cancer combination chemotherapy; cancer surgery; clinical outcome; constipation; controlled study; creatine kinase blood level; diarrhea; double blind procedure; drug safety; drug tolerability; fatigue; female; gene overexpression; heart ejection fraction; histopathology; human; hypertransaminasemia; immunohistochemistry; Indonesia; invasive lobular breast carcinoma; leukopenia; lung metastasis; major clinical study; modified radical mastectomy; muc |
Korean Cancer Association |
15982998 |
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33705623 |
Article |
Q1 |
1668 |
1870 |
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