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334 |
Yasmon A., Agnes A., Febriani R., Kusumaningrum A., Andriansjah, Sudarmono P. |
41462004500;57352939000;57212580873;57211641695;57352939200;6507855437; |
Identification of nontuberculous mycobacteria (Ntm) species isolated from the sputum, skin and soft tissue of patients in Jakarta, Indonesia |
2021 |
Southeast Asian Journal of Tropical Medicine and Public Health |
52 |
5 |
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644 |
650 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119897125&partnerID=40&md5=fa2f76f9076156267a3d1d05310fb824 |
Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Yasmon, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Agnes, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Febriani, R., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kusumaningrum, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Andriansjah, Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sudarmono, P., Department of Microbiology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Knowing the species of nontuberculous mycobacteria (NTM) causing disease in a patient population can guide empiric treatment. In this study we aimed to determine the species of NTM causing disease in a selected patient population in Indonesia in order to guide empiric treatment. We retrospectively reviewed the records of all patients treated at 5 hospitals in Jakarta, Indonesia, diagnosed with NTM infection during January 2018-December 2019. The inclusion criterion for study subjects was having a positive test for NTM and the exclusion criterion was having a positive culture for Mycobacterium tuberculosis complex. Study subjects were confirmed to have NTM by a MPT64 rapid test. The species of NTM were identified by DNA sequencing of Mycobacterium 16S rRNA. A total of 15 patients were determined to have NTM at the study institutions during the study period, 53% male. The average age of study subjects was 45 (range: 4-83) years. The NTM positive specimens were obtained from the sputum (n = 5), skin and soft tissue biopsies (n = 5), and lymphoid tissue biopsies (n = 5). Of the 15 study subjects, 8 (53%) had M. abscessus, 5 (33%) had M. intracellulare, 1 (7%) had M. avium and 1 (7%) had M. cookii. Of the 5 NTM isolates from the sputum, 3 isolates were M. abscessus, 1 isolate was M. intracellulare and 1 isolate was M. Cookii. Of the 5 NTM isolates from skin and soft biopsies, 3 isolates were M. abscessus and the other 2 isolates were M. intracellulare. Of the 5 NTM isolates from lymphoid tissue biopsies, 2 isolates were M. abscessus, 2 isolates were M. intracellulare and 1 isolate was M. Avium. In our study, the most common NTIM isolate was M. abscessus. Empiric treatment of NTM in the study population should include coverage of M. abscessus. Further studies with larger numbers of subjects from multiple institutions are needed to determine if these findings hold true for other parts of Indonesia. © 2021, SEAMEO TROPMED Network. All rights reserved. |
Lymphoid; Mycobacterium; NTM; Skin and soft; Sputum |
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SEAMEO TROPMED Network |
01251562 |
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Article |
Q4 |
214 |
18533 |
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391 |
Wente-Schulz S., Aksenova M., Awan A., Ambarsari C.G., Becherucci F., Emma F., Fila M., Francisco T., Gokce I., Gülhan B., Hansen M., Jahnukainen T., Kallash M., Kamperis K., Mason S., Mastrangelo A., Mencarelli F., Niwinska-Faryna B., Riordan M., Rus R.R., Saygili S., Serdaroglu E., Taner S., Topaloglu R., Vidal E., Woroniecki R., Yel S., Zieg J., Pape L., Boyer O., Buder K., Bulut İ.K., Cornelissen E.A.M., del Mar Espino Hernández M., Hooman N., Kemper M., Maquet J., Santos F., Walden U., The international TIN study group |
57219293227;56461027300;7005794049;57211850895;23391748500;6701866332;47760976500;55642167100;16238883200;16244621000;57026872000;6602193869;55189985500;6507713677;56025783100;16245571200;23989069700;24402868000;36828392800;56126830800;36926397400;55910586900;57204046122;7005610220;57200885825;8351699100;43861951500;37762449000;7007073757;8509255100;57423156500;42360924700;7003896668;56868570600;22634317400;55946766900;57199406014;7202141204;57189522337; |
Aetiology, course and treatment of acute tubulointerstitial nephritis in paediatric patients: A cross-sectional web-based survey |
2021 |
BMJ Open |
11 |
5 |
e047059 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107244372&doi=10.1136%2fbmjopen-2020-047059&partnerID=40&md5=8b9d8549b7d6c5d3a71a823dffc235d5 |
Department of Pediatric Nephrology, MHH, Hannover, Germany; Department of Pediatric Nephrology, Veltischev Research and Clinical Institute for Pediatrics, The Pirogov Russian National Research Medical University, Moskva, Russian Federation; Department of Pediatric Nephrology, Temple Street Children's University Hospital, Dublin, Ireland; Department of Pediatric Nephrology, Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Central Jakarta, Indonesia; Department of Pediatric Nephrology, Meyer Children's Hospital, Florence, Italy; Department of Pediatric Nephrology, Bambino Gesù Children's Hospital, Roma, Italy; Department of Pediatric Nephrology, Montpellier University, Arnaud de Villeneuve Hospital, Montpellier, France; Department of Pediatric Nephrology, Dona Estefânia Hospital, Lisboa, Portugal; Department of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey; Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey; KfH Centre of Pediatric Nephrology, Clementine Kinderhospital, Frankfurt am Main, Germany; Department of Pediatric Nephrology and Transplantation, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland; Department of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH, United States; Department of Pediatric Nephrology, Aarhus University Hospital, Aarhus, Denmark; Department of Pediatric Nephrology, Connecticut Children's Medical Center, Hartford, CT, United States; Department of Pediatric Nephrology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pediatric Nephrology, Azienda Ospedaliero-Universitaria di Bologna, Ospedale S. Orsola-Malpighi, Bologna, Italy; Department of Pediatric Nephrology, Karolinska University Hospital, Stockholm, Sweden; Department of Pediatric Nephrology, University Children's Hospital, Ljubljana, Slovenia; Department of Pediatric Nephrology, Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey; Department of Pediatric Nephrology, Dr Behcet Uz Children Hospital, Izmir, Turkey; Department of Pediatric Nephrology, Faculty of Medicine, Ege University, Izmir, Turkey; Department of Pediatric Nephrology, University Hospital of Padova, Padova, Italy; Department of Pediatric Nephrology, Stony Brook Children's Hospital, Stony Brook, NY, United States; Department of Pediatric Nephrology, Faculty of Medicine, Erciyes University, Kayseri, Turkey; Department of Pediatric Nephrology, 2nf Faculty of Medicine, University Hospital Motol, Charles University, Praha, Czech Republic; Department of Pediatrics II, University Hospital Essen, Essen, Germany; Hôpital Necker-Enfants malades, MARHEA, Institut Imagine, Université de Paris, Paris, France; Pediatric Department, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany; Ege University Faculty of Medicine, Izmir, Turkey; Radboud University Medical Center, Nijmegen, Netherlands; Hospital Universitario 12 de Octubre, Madrid, Spain; Ali-Asghar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran; Asklepios Medical School, Hamburg, Germany; CHC Liège, Belgium; Pediatric Nephrology, Hospital Universitario Central de Asturias, University of Oviedo, Spain; Universitätsklinikum Kinderklinik Augsburg, Germany |
Wente-Schulz, S., Department of Pediatric Nephrology, MHH, Hannover, Germany; Aksenova, M., Department of Pediatric Nephrology, Veltischev Research and Clinical Institute for Pediatrics, The Pirogov Russian National Research Medical University, Moskva, Russian Federation; Awan, A., Department of Pediatric Nephrology, Temple Street Children's University Hospital, Dublin, Ireland; Ambarsari, C.G., Department of Pediatric Nephrology, Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Central Jakarta, Indonesia; Becherucci, F., Department of Pediatric Nephrology, Meyer Children's Hospital, Florence, Italy; Emma, F., Department of Pediatric Nephrology, Bambino Gesù Children's Hospital, Roma, Italy; Fila, M., Department of Pediatric Nephrology, Montpellier University, Arnaud de Villeneuve Hospital, Montpellier, France; Francisco, T., Department of Pediatric Nephrology, Dona Estefânia Hospital, Lisboa, Portugal; Gokce, I., Department of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey; Gülhan, B., Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey; Hansen, M., KfH Centre of Pediatric Nephrology, Clementine Kinderhospital, Frankfurt am Main, Germany; Jahnukainen, T., Department of Pediatric Nephrology and Transplantation, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland; Kallash, M., Department of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH, United States; Kamperis, K., Department of Pediatric Nephrology, Aarhus University Hospital, Aarhus, Denmark; Mason, S., Department of Pediatric Nephrology, Connecticut Children's Medical Center, Hartford, CT, United States; Mastrangelo, A., Department of Pediatric Nephrology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Mencarelli, F., Department of Pediatric Nephrology, Azienda Ospedaliero-Universitaria di Bologna, Ospedale S. Orsola-Malpighi, Bologna, Italy; Niwinska-Faryna, B., Department of Pediatric Nephrology, Karolinska University Hospital, Stockholm, Sweden; Riordan, M., Department of Pediatric Nephrology, Temple Street Children's University Hospital, Dublin, Ireland; Rus, R.R., Department of Pediatric Nephrology, University Children's Hospital, Ljubljana, Slovenia; Saygili, S., Department of Pediatric Nephrology, Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey; Serdaroglu, E., Department of Pediatric Nephrology, Dr Behcet Uz Children Hospital, Izmir, Turkey; Taner, S., Department of Pediatric Nephrology, Faculty of Medicine, Ege University, Izmir, Turkey; Topaloglu, R., Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey; Vidal, E., Department of Pediatric Nephrology, University Hospital of Padova, Padova, Italy; Woroniecki, R., Department of Pediatric Nephrology, Stony Brook Children's Hospital, Stony Brook, NY, United States; Yel, S., Department of Pediatric Nephrology, Faculty of Medicine, Erciyes University, Kayseri, Turkey; Zieg, J., Department of Pediatric Nephrology, 2nf Faculty of Medicine, University Hospital Motol, Charles University, Praha, Czech Republic; Pape, L., Department of Pediatrics II, University Hospital Essen, Essen, Germany; Boyer, O., Hôpital Necker-Enfants malades, MARHEA, Institut Imagine, Université de Paris, Paris, France; Buder, K., Pediatric Department, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany; Bulut, İ.K., Ege University Faculty of Medicine, Izmir, Turkey; Cornelissen, E.A.M., Radboud University Medical Center, Nijmegen, Netherlands; del Mar Espino Hernández, M., Hospital Universitario 12 de Octubre, Madrid, Spain; Hooman, N., Ali-Asghar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran; Kemper, M., Asklepios Medical School, Hamburg, Germany; Maquet, J., CHC Liège, Belgium; Santos, F., Pediatric Nephrology, Hospital Universitario Central de Asturias, University of Oviedo, Spain; Walden, U., Universitätsklinikum Kinderklinik Augsburg, Germany; The international TIN study group |
Background Acute tubulointerstitial nephritis (TIN) is a significant cause of acute renal failure in paediatric and adult patients. There are no large paediatric series focusing on the aetiology, treatment and courses of acute TIN. Patients, design and setting We collected retrospective clinical data from paediatric patients with acute biopsy-proven TIN by means of an online survey. Members of four professional societies were invited to participate. Results Thirty-nine physicians from 18 countries responded. 171 patients with acute TIN were included (54% female, median age 12 years). The most frequent causes were tubulointerstitial nephritis and uveitis syndrome in 31% and drug-induced TIN in 30% (the majority of these caused by non-steroidal anti-inflammatory drugs). In 28% of patients, no initiating noxae were identified (idiopathic TIN). Median estimated glomerular filtration rate (eGFR) rose significantly from 31 at time of renal biopsy to 86 mL/ min/1.73 m2 3-6 months later (p<0.001). After 3-6 months, eGFR normalised in 41% of patients (eGFR ≥90 mL/ min/1.73 m2), with only 3% having severe or end-stage impairment of renal function (<30 mL/min/1.73 m2). 80% of patients received corticosteroid therapy. Median eGFR after 3-6 months did not differ between steroid-treated and steroid-untreated patients. Other immunosuppressants were used in 18% (n=31) of patients, 21 of whom received mycophenolate mofetil. Conclusions Despite different aetiologies, acute paediatric TIN had a favourable outcome overall with 88% of patients showing no or mild impairment of eGFR after 3-6 months. Prospective randomised controlled trials are needed to evaluate the efficacy of glucocorticoid treatment in paediatric patients with acute TIN. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
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aciclovir; amoxicillin plus clavulanic acid; antiinfective agent; bee venom; chlorpheniramine maleate; corticosteroid; cotrimoxazole; flurbiprofen; herbaceous agent; hydrochlorothiazide; ibuprofen; immunosuppressive agent; ketoprofen; levetiracetam; mesalazine; methylprednisolone; midecamycin; morniflumate; mycophenolate mofetil; nonsteroid antiinflammatory agent; oxcarbazepine; paracetamol; penicillin G potassium; prednisolone; prednisone; toxic substance; anuria; arthralgia; Article; child; clinical feature; cohort analysis; controlled study; corticosteroid therapy; cross-sectional study; disease course; end stage renal disease; enuresis; estimated glomerular filtration rate; eye disease; fatigue; female; fever; flank pain; glucosuria; headache; health care survey; hematuria; human; huma |
BMJ Publishing Group |
20446055 |
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34049919 |
Article |
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1132 |
3624 |
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400 |
Han W.M., Jiamsakul A., Salleh N.A.M., Choi J.Y., Huy B.V., Yunihastuti E., Do C.D., Merati T.P., Gani Y.M., Kiertiburanakul S., Zhang F., Chan Y.-J., Lee M.-P., Chaiwarith R., Ng O.T., Khusuwan S., Ditangco R., Kumarasamy N., Sangle S., Ross J., Avihingsanon A., Ly P.S., Khol V., Zhang F.J., Zhao H.X., Han N., Lee M.P., Li P.C.K., Lam W., Chan Y.T., Kumarasamy N., Ezhilarasi C., Pujari S., Joshi K., Gaikwad S., Chitalikar A., Sangle S., Mave V., Marbaniang I., Nimkar S., Merati T.P., Wirawan D.N., Yuliana F., Yunihastuti E., Widhani A., Maria S., Karjadi T.H., Tanuma J., Oka S., Nishijima T., Choi J.Y., Na S., Kim J.M., Gani Y.M., Rudi N.B., Azwa I., Kamarulzaman A., Syed Omar S.F., Ponnampalavanar S., Ditangco R., Pasayan M.K., Mationg M.L., Chan Y.J., Ku W.W., Wu P.C., Ke E., Ng O.T., Lim P.L., Lee L.S., Liang D., Avihingsanon A., Gatechompol S., Phanuphak P., Phadungphon C., Phuphuakrat A., Chumla L., Sanmeema N., Chaiwarith R., Sirisanthana T., Praparattanapan J., Nuket K., Khusuwan S., Kantipong P., Kambua P., Nguyen K.V., Bui H.V., Nguyen D.T.H., Nguyen D.T., Do C.D., Ngo A.V., Nguyen L.T., Sohn A.H., Ross J.L., Petersen B., Law M.G., Jiamsakul A., Bijker R., Rupasinghe D., TREAT Asia HIV Observational Database (TAHOD) of the International Epidemiology Databases to Evaluate AIDS (IeDEA) Asia-Pacific Group |
57201984684;55285745500;57209499322;48761023600;55757403300;57221273925;55035577700;8935806500;57188842533;6506539792;23007277900;57258255400;57309539000;13806165200;57215769524;56166613100;55406840800;7003549856;6602877716;57193109926;57196347321;57204852770;57188842644;55503803800;35796801900;57206253688;56143671100;57203375227;57188836039;57188839065;55412491000;55413091200;57205894660;35227451500;55273903300;57188839029;57257928100;24778446900;57189801547;56820043000;57203678680;6601921496;57202976978;8850357600;57202561455;57213345044;57219422563;57208428839;57202558648;57226409961;57294788000;14037572300;7601387767;57188842533;57257789600;55553159100;6603019663;55295731300;36768852500;57258598000;57207954173;36936083900;33667461800;55856943500;56514424400;57257813200;57203665233;10041498300;55992506400;57258040600;57200282477;57193906863;7004982661;56015716600;8277552900;56515326900;55992497800;57203665049;7004277229;35185428900;57192871045;56166613100;6603580797;55285745100;56370854300;56498653200;56970337500;57190300831;56658396600;57208054163;41961438300;7006405275;57217343074;56406054800;55556254800;55285745500;57188697907;57205313395; |
HIV treatment outcomes among people who acquired HIV via injecting drug use in the Asia-Pacific region: a longitudinal cohort study |
2021 |
Journal of the International AIDS Society |
24 |
5 |
e25736 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106697623&doi=10.1002%2fjia2.25736&partnerID=40&md5=5b62ec1b7839280e4b8e69702122c64a |
Kirby Institute, UNSW, Sydney, Australia; HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia; Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; National Hospital for Tropical Diseases, Hanoi, Viet Nam; Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Bach Mai Hospital, Hanoi, Viet Nam; Faculty of Medicine, Udayana University & Sanglah Hospital, Bali, Indonesia; Hospital Sungai Buloh, Sungai Buloh, Malaysia; Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Beijing Ditan Hospital, Capital Medical University, Beijing, China; Taipei Veterans General Hospital, Taipei, Taiwan; Queen Elizabeth Hospital, Hong Kong; Research Institute for Health Sciences, Chiang Mai, Thailand; Tan Tock Seng Hospital, Tan Tock Seng, Singapore; Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHSChennai, India; BJ Government Medical College and Sassoon General Hospital, Pune, India; TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; Beijing Ditan Hospital, Capital Medical University, Beijing, China; Queen Elizabeth Hospital, Hong Kong; Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India; Institute of Infectious Diseases, Pune, India; BJ Government Medical College and Sassoon General Hospital, Pune, India; Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; National Center for Global Health and Medicine, Tokyo, Japan; Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Hospital Sungai Buloh, Sungai Buloh, Malaysia; University Malaya Medical Centre, Kuala Lumpur, Malaysia; Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Taipei Veterans General Hospital, Taipei, Taiwan; Tan Tock Seng Hospital, Singapore; HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Research Institute for Health Sciences, Chiang Mai, Thailand; Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; National Hospital for Tropical Diseases, Hanoi, Viet Nam; Bach Mai Hospital, Hanoi, Viet Nam; TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; The Kirby Institute, UNSW SydneyNSW, Australia |
Han, W.M., Kirby Institute, UNSW, Sydney, Australia, HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Jiamsakul, A., Kirby Institute, UNSW, Sydney, Australia, The Kirby Institute, UNSW SydneyNSW, Australia; Salleh, N.A.M., Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia, Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia; Choi, J.Y., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Huy, B.V., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Yunihastuti, E., Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Do, C.D., Bach Mai Hospital, Hanoi, Viet Nam; Merati, T.P., Faculty of Medicine, Udayana University & Sanglah Hospital, Bali, Indonesia; Gani, Y.M., Hospital Sungai Buloh, Sungai Buloh, Malaysia, Hospital Sungai Buloh, Sungai Buloh, Malaysia; Kiertiburanakul, S., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Zhang, F., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Chan, Y.-J., Taipei Veterans General Hospital, Taipei, Taiwan; Lee, M.-P., Queen Elizabeth Hospital, Hong Kong; Chaiwarith, R., Research Institute for Health Sciences, Chiang Mai, Thailand; Ng, O.T., Tan Tock Seng Hospital, Tan Tock Seng, Singapore; Khusuwan, S., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Ditangco, R., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Kumarasamy, N., Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHSChennai, India; Sangle, S., BJ Government Medical College and Sassoon General Hospital, Pune, India; Ross, J., TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Avihingsanon, A., HIV-NAT, Thai Red Cross AIDS Research Centre, Bangkok, Thailand, Tuberculosis Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Ly, P.S., National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; Khol, V., National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; Zhang, F.J., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Zhao, H.X., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Han, N., Beijing Ditan Hospital, Capital Medical University, Beijing, China; Lee, M.P., Queen Elizabeth Hospital, Hong Kong; Li, P.C.K., Queen Elizabeth Hospital, Hong Kong; Lam, W., Queen Elizabeth Hospital, Hong Kong; Chan, Y.T., Queen Elizabeth Hospital, Hong Kong; Kumarasamy, N., Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India; Ezhilarasi, C., Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India; Pujari, S., Institute of Infectious Diseases, Pune, India; Joshi, K., Institute of Infectious Diseases, Pune, India; Gaikwad, S., Institute of Infectious Diseases, Pune, India; Chitalikar, A., Institute of Infectious Diseases, Pune, India; Sangle, S., BJ Government Medical College and Sassoon General Hospital, Pune, India; Mave, V., BJ Government Medical College and Sassoon General Hospital, Pune, India; Marbaniang, I., BJ Government Medical College and Sassoon General Hospital, Pune, India; Nimkar, S., BJ Government Medical College and Sassoon General Hospital, Pune, India; Merati, T.P., Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Wirawan, D.N., Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Yuliana, F., Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Yunihastuti, E., Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Widhani, A., Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Maria, S., Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Karjadi, T.H., Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Tanuma, J., National Center for Global Health and Medicine, Tokyo, Japan; Oka, S., National Center for Global Health and Medicine, Tokyo, Japan; Nishijima, T., National Center for Global Health and Medicine, Tokyo, Japan; Choi, J.Y., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Na, S., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Kim, J.M., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Gani, Y.M., Hospital Sungai Buloh, Sungai Buloh, Malaysia, Hospital Sungai Buloh, Sungai Buloh, Malaysia; Rudi, N.B., Hospital Sungai Buloh, Sungai Buloh, Malaysia; Azwa, I., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Kamarulzaman, A., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Syed Omar, S.F., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Ponnampalavanar, S., University Malaya Medical Centre, Kuala Lumpur, Malaysia; Ditangco, R., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Pasayan, M.K., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Mationg, M.L., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Chan, Y.J., Taipei Veterans General Hospital, Taipei, Taiwan; Ku, W.W., Taipei Veterans General Hospital, Taipei, Taiwan; Wu, P.C., Taipei Veterans General Hospital, Taipei, Taiwan; Ke, E., Taipei Veterans General Hospital, Taipei, Taiwan; Ng, O.T., Tan Tock Seng Hospital, Singapore; Lim, P.L., Tan Tock Seng Hospital, Singapore; Lee, L.S., Tan Tock Seng Hospital, Singapore; Liang, D., Tan Tock Seng Hospital, Singapore; Avihingsanon, A., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Gatechompol, S., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Phanuphak, P., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Phadungphon, C., HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Phuphuakrat, A., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Chumla, L., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Sanmeema, N., Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; Chaiwarith, R., Research Institute for Health Sciences, Chiang Mai, Thailand; Sirisanthana, T., Research Institute for Health Sciences, Chiang Mai, Thailand; Praparattanapan, J., Research Institute for Health Sciences, Chiang Mai, Thailand; Nuket, K., Research Institute for Health Sciences, Chiang Mai, Thailand; Khusuwan, S., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Kantipong, P., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Kambua, P., Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; Nguyen, K.V., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Bui, H.V., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Nguyen, D.T.H., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Nguyen, D.T., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Do, C.D., Bach Mai Hospital, Hanoi, Viet Nam; Ngo, A.V., Bach Mai Hospital, Hanoi, Viet Nam; Nguyen, L.T., Bach Mai Hospital, Hanoi, Viet Nam; Sohn, A.H., TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Ross, J.L., TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Petersen, B., TREAT Asia, amfAR - The Foundation for AIDS Research, Bangkok, Thailand; Law, M.G., The Kirby Institute, UNSW SydneyNSW, Australia; Jiamsakul, A., Kirby Institute, UNSW, Sydney, Australia, The Kirby Institute, UNSW SydneyNSW, Australia; Bijker, R., The Kirby Institute, UNSW SydneyNSW, Australia; Rupasinghe, D., The Kirby Institute, UNSW SydneyNSW, Australia; TREAT Asia HIV Observational Database (TAHOD) of the International Epidemiology Databases to Evaluate AIDS (IeDEA) Asia-Pacific Group |
INTRODUCTION: Data on HIV treatment outcomes in people who inject drugs (PWID) in the Asia-Pacific are sparse despite the high burden of drug use. We assessed immunological and virological responses, AIDS-defining events and mortality among PWID receiving antiretroviral therapy (ART). METHODS: We investigated HIV treatment outcomes among people who acquired HIV via injecting drug use in the TREAT Asia HIV Observational Database (TAHOD) between January 2003 and March 2019. Trends in CD4 count and viral suppression (VS, HIV viral load <1000 copies/mL) were assessed. Factors associated with mean CD4 changes were analysed using repeated measures linear regression, and combined AIDS event and mortality were analysed using survival analysis. RESULTS: Of 622 PWID from 12 countries in the Asia-Pacific, 93% were male and the median age at ART initiation was 31 years (IQR, 28 to 34). The median pre-ART CD4 count was 71 cells/µL. CD4 counts increased over time, with a mean difference of 401 (95% CI, 372 to 457) cells/µL at year-10 (n = 78). Higher follow-up HIV viral load and pre-ART CD4 counts were associated with smaller increases in CD4 counts. Among 361 PWID with ≥1 viral load after six months on ART, proportions with VS were 82%, 88% and 93% at 2-, 5- and 10-years following ART initiation. There were 52 new AIDS-defining events and 50 deaths during 3347 person-years of follow-up (PYS) (incidence 3.05/100 PYS, 95% CI, 2.51 to 3.70). Previous AIDS or TB diagnosis, lower current CD4 count and adherence <95% were associated with combined new AIDS-defining event and death. CONCLUSIONS: Despite improved outcomes over time, our findings highlight the need for rapid ART initiation and adherence support among PWID within Asian settings. © 2021 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society. |
Asia-Pacific; CD4 recovery; HIV/AIDS; people who inject drugs; treatment outcomes; tuberculosis; viral suppression |
nonnucleoside reverse transcriptase inhibitor; proteinase inhibitor; anti human immunodeficiency virus agent; drug; acquired immune deficiency syndrome; adult; all cause mortality; antiretroviral therapy; Article; Asia; CD4 lymphocyte count; cohort analysis; coinfection; female; follow up; hepatitis B; hepatitis C; human; Human immunodeficiency virus; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; incidence; injection drug user; longitudinal study; major clinical study; male; survival analysis; treatment outcome; tuberculosis; virus load; Human immunodeficiency virus infection; treatment outcome; Anti-HIV Agents; Asia; CD4 Lymphocyte Count; Cohort Studies; HIV Infections; Humans; Longitudinal Studies; Male; Pharmaceutical Preparations; Treatment Outc |
John Wiley and Sons Inc |
17582652 |
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34021711 |
Article |
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2724 |
762 |
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403 |
Fuady A., Nuraini N., Sukandar K.K., Lestari B.W. |
37085331400;24605696400;57216947725;56589945500; |
Targeted vaccine allocation could increase the covid-19 vaccine benefits amidst its lack of availability: A mathematical modeling study in indonesia |
2021 |
Vaccines |
9 |
5 |
462 |
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9 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105974918&doi=10.3390%2fvaccines9050462&partnerID=40&md5=4a9375c9281f8f4834500172552d5373 |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10310, Indonesia; Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3015 GD, Netherlands; Department of Mathematics, Institut Teknologi Bandung, Bandung, 40132, Indonesia; Epidemiology Group of COVID-19 Task Force for West Java, Bandung, 40171, Indonesia; Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, Indonesia; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, 6525 GA, Netherlands |
Fuady, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10310, Indonesia, Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3015 GD, Netherlands; Nuraini, N., Department of Mathematics, Institut Teknologi Bandung, Bandung, 40132, Indonesia, Epidemiology Group of COVID-19 Task Force for West Java, Bandung, 40171, Indonesia; Sukandar, K.K., Department of Mathematics, Institut Teknologi Bandung, Bandung, 40132, Indonesia; Lestari, B.W., Epidemiology Group of COVID-19 Task Force for West Java, Bandung, 40171, Indonesia, Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, Indonesia, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, 6525 GA, Netherlands |
With a limited number of vaccines and healthcare capacity shortages, particularly in low-and middle-income countries, vaccination programs should seek the most efficient strategy to reduce the negative impact of the COVID-19 pandemics. This study aims at assessing several scenarios of delivering the vaccine to people in Indonesia. We develop a model for several scenarios of delivering vaccines: without vaccination, fair distribution, and targeted distribution to five and eight districts with the highest COVID-19 incidence in West Java, one of the most COVID-19-affected regions in Indonesia. We calculate the needs of vaccines and healthcare staff for the program, then simulate the model for the initial 4-month and one-year scenarios. A one-year vaccination program would require 232,000 inoculations per day by 4833 vaccinators. Targeted vaccine allocation based on the burden of COVID-19 cases could benefit the COVID-19 vaccination program by lowering at least 5000 active cases. The benefits would increase by improving the number of vaccines and healthcare staff. Amidst lacking available vaccines, targeted vaccine allocation based on the burden of COVID-19 cases could increase the benefit of the COVID-19 vaccination program but still requires progressive efforts to improve healthcare capacity and vaccine availability for optimal protection for people. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
COVID-19; Low-and middle-income countries; Modeling; Strategy; Vaccine |
SARS-CoV-2 vaccine; Article; coronavirus disease 2019; disease model; disease predisposition; disease transmission; drug bioavailability; drug efficacy; health care need; health care personnel; human; Indonesia; infection rate; mathematical model; mortality; quarantine; reinfection; resource allocation; SIQRD model; vaccination |
MDPI AG |
2076393X |
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Article |
Q1 |
1296 |
2913 |
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404 |
Harbuwono D.S., Sazli B.I., Kurniawan F., Darmowidjojo B., Koesnoe S., Tahapary D.L. |
36056341600;57223390172;57202309006;57210642934;26028015000;55944492500; |
The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus |
2021 |
Heliyon |
7 |
5 |
e06773 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105783321&doi=10.1016%2fj.heliyon.2021.e06773&partnerID=40&md5=2dd413b4d090b7268ec8e92f9121b6ce |
Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Division of Allergy and Immunology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia |
Harbuwono, D.S., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Sazli, B.I., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Kurniawan, F., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Darmowidjojo, B., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Koesnoe, S., Division of Allergy and Immunology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Tahapary, D.L., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia |
Background/Aims: Ramadan fasting creates changes in lifestyle, causing biochemical alterations that affect glucose metabolism and insulin sensitivity. This study aims to assess the impact of Ramadan fasting on glycemic control and Fetuin-A, a glycoprotein that affects insulin resistance, in patients with type 2 diabetes mellitus (T2DM). Materials and methods: This was a prospective study done among 37 patients with T2DM from Internal Medicine Polyclinic in a hospital in Jakarta, Indonesia. Anthropometric data as well as Hemoglobin A1c (HbA1c), Fasting Blood Glucose (FBG), and Fetuin-A levels of the subjects were measured in three time points: before, during, and after Ramadan fasting. A bivariate analysis was done to see the effect of Ramadan fasting on those parameters. Results: Ramadan fasting reduced Fetuin-A levels [median (minimum–maximum), 5.35 (2.91–7.81) vs. 3.22 (2.35–5.60) mg/dl; p = 0.039] four weeks after the end of Ramadan compared to pre-Ramadan. After two weeks of Ramadan fasting, we found a significant reduction in body weight, BMI, FBG, and HbA1c levels which rebounded to baseline level after Ramadan. Conclusion: Ramadan fasting was associated with a significant decrease in Fetuin-A level post Ramadan. © 2021 The Authors |
Diabetes mellitus; Fetuin-A; Glycoprotein; Insulin resistance; Ramadan fasting |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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405 |
Sampurna M.T.A., Rohsiswatmo R., Primadi A., Wandita S., Sulistijono E., Bos A.F., Sauer P.J.J., Hulzebos C.V., Dijk P.H. |
57201733407;55533574600;8422152900;57194904658;57218101844;36839156800;57191375642;6603928053;6701798049; |
Corrigendum to “The knowledge of Indonesian pediatric residents on hyperbilirubinemia management” [Heliyon 7 (4) (2021) e06661](S2405844021007647)(10.1016/j.heliyon.2021.e06661) |
2021 |
Heliyon |
7 |
5 |
e07007 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105737450&doi=10.1016%2fj.heliyon.2021.e07007&partnerID=40&md5=f1c3a5a39332f7f89a1e521e66c2589f |
Neonatology Division, Department of Pediatrics, Airlangga University Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Neonatology Division, Department of Pediatrics, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatrics, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Neonatology Division, Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Pediatrics, Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands |
Sampurna, M.T.A., Neonatology Division, Department of Pediatrics, Airlangga University Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Rohsiswatmo, R., Neonatology Division, Department of Pediatrics, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Primadi, A., Department of Pediatrics, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Wandita, S., Neonatology Division, Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Sulistijono, E., Department of Pediatrics, Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Bos, A.F., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Sauer, P.J.J., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Hulzebos, C.V., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Dijk, P.H., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands |
In the original published version of this article, the authors provided the incorrect institutional review board number, 1060/KEPK/III/2019. This has now been corrected to 390/Panke.KKE/V/2017. The authors apologise for this mistake. Both the HTML and PDF versions of the article have been updated to correct the error. © 2021 The Author(s) |
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Elsevier Ltd |
24058440 |
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Erratum |
Q1 |
455 |
10919 |
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412 |
Pulungan A., Andarie A.A., Soesanti F., Yassien M.R., De Bruin C., Wijaya A., Firmansyah A., Wit J.M. |
57192905981;57195935134;37068080600;57223039155;57028043300;57225459566;6602915502;7101895972; |
Anthropometric, biochemical and hormonal profiles of the partially admixed pygmoid group in Rampasasa (Flores, Indonesia) |
2021 |
Journal of Pediatric Endocrinology and Metabolism |
34 |
5 |
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547 |
557 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104614948&doi=10.1515%2fjpem-2020-0526&partnerID=40&md5=64730b2ca3a487374a34509077be3f0d |
Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pediatrics, Leiden University Medical Center, Leiden, Netherlands; Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia |
Pulungan, A., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jl. Diponegoro No. 71, Jakarta, 10430, Indonesia; Andarie, A.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soesanti, F., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yassien, M.R., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; De Bruin, C., Department of Pediatrics, Leiden University Medical Center, Leiden, Netherlands; Wijaya, A., Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia; Firmansyah, A., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wit, J.M., Department of Pediatrics, Leiden University Medical Center, Leiden, Netherlands |
Objectives: We performed a cross-sectional study on anthropometric and laboratory characteristics of inhabitants of Rampasasa (Flores, Indonesia). Adults were categorised according to ancestry into three groups: pygmoid (P/P, offspring of pygmoid parents, n=8), mixed pygmoid (P/N, offspring of pygmoid and non-pygmoid parents, n=12) and non-pygmoid (N/N, n=10). Children (n=28) were P/N. Methods: Measurements included height, weight, sitting height, arm span, head circumference, haematological analysis and serum albumin, calcium, vitamin D, insulinlike growth factor-I (IGF-I) and IGF binding protein 3 (IGFBP-3). Pubertal stage and bone age was assessed in children. Anthropometric data were expressed as standard deviation score (SDS) for age. IGF-I, IGFBP-3 and IGF-I/ IGFBP-3 ratio were expressed as SDS for age, bone age and pubertal stage. Results: Mean height SDS showed a gradient from P/P (-4.0) via P/N (-3.2) to N/N (-2.3) (-3.4, -3.1 and -2.2 adjusted for age-associated shrinking). Sitting height and head circumference showed similar gradients. Serum IGF-I SDS was similar among groups (approximately -1 SDS). IGFBP-3 SDS tended toward a gradient from P/P (-1.9) via P/N (-1.5) to N/N (-1.1), but IGF-I/IGFBP-3 ratio was normal in all groups. In P/P and P/N, mean head circumference SDS was >2 SD greater than mean height SDS. Children showed a progressive growth failure and bone age delay, delayed female pubertal onset and an initial low serum IGF-I, normal IGFBP-3 and low IGF-I/IGFBP-3 ratio. Conclusions: P/P showed proportionate short stature with relative macrocephaly and relatively low IGFBP-3; P/N presented an intermediate pattern. P/N children were progressively short, showed delayed skeletal maturation, delayed puberty in girls and low IGF-I and IGF-I/IGFBP-3. © 2021 De Gruyter. All rights reserved. |
Growth; Head circumference; IGF-I; IGFBP-3; Negritos; Pygmies; Short stature; Vitamin D deficiency |
albumin; calcium; somatomedin binding protein 3; somatomedin C receptor; vitamin D; IGFBP3 protein, human; somatomedin binding protein 3; somatomedin C; adult; albumin blood level; analytical parameters; anthropology; anthropometry; Article; biochemistry; blood analysis; bone age; calcium blood level; child; controlled study; cross-sectional study; crossover procedure; female; head circumference; hormone determination; human; Indonesia; macrocephaly; male; molecular dynamics; population research; protein blood level; puberty; pygmy; scoring system; vitamin blood level; anthropometry; blood; body mass; body weight; bone disease; ethnic group; follow up; growth disorder; infant; metabolism; middle aged; newborn; pathology; preschool child; prognosis; Adult; Anthropometry; Body Mass Index; Bo |
De Gruyter Open Ltd |
0334018X |
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33851527 |
Article |
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10041 |
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419 |
Iwai M., Tulafu M., Togo S., Kawaji H., Kadoya K., Namba Y., Jin J., Watanabe J., Okabe T., Hidayat M., Sumiyoshi I., Itoh M., Koyama Y., Ito Y., Orimo A., Takamochi K., Oh S., Suzuki K., Hayashizaki Y., Yoshida K., Takahashi K. |
56357096800;55818028100;9533914900;57196621148;57193562606;55413965500;57221345975;57202019639;57208252941;56435992700;57202003876;57218355452;57202921569;57225926629;56922531400;57070836300;56922435100;57221017119;57216108710;55725231300;57226207751; |
Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin α11 expression |
2021 |
Molecular Oncology |
15 |
5 |
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1507 |
1527 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103164588&doi=10.1002%2f1878-0261.12937&partnerID=40&md5=b2e053e6ecbd024c8cbcf42081179238 |
Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Leading Center for the Development and Research of Cancer Medicine, Juntendo University, Tokyo, Japan; Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Japan; Preventive Medicine and Applied Genomics Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Department of Respiratory and Critical Care Medicine, National Center of Gerontology, Beijing Hospital, China; Department of Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine, Jakarta, Indonesia; Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan; Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Japan; Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Faculty of Biology-Oriented Science and Technology, Kindai University, Wakayama, Japan |
Iwai, M., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Tulafu, M., Leading Center for the Development and Research of Cancer Medicine, Juntendo University, Tokyo, Japan; Togo, S., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Kawaji, H., Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Japan, Preventive Medicine and Applied Genomics Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Kadoya, K., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Namba, Y., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Jin, J., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan, Department of Respiratory and Critical Care Medicine, National Center of Gerontology, Beijing Hospital, China; Watanabe, J., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Okabe, T., Leading Center for the Development and Research of Cancer Medicine, Juntendo University, Tokyo, Japan; Hidayat, M., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan, Department of Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine, Jakarta, Indonesia; Sumiyoshi, I., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Itoh, M., RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Koyama, Y., Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan, Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Japan; Ito, Y., Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan; Orimo, A., Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan; Takamochi, K., Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Oh, S., Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Suzuki, K., Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Hayashizaki, Y., RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Yoshida, K., Faculty of Biology-Oriented Science and Technology, Kindai University, Wakayama, Japan; Takahashi, K., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan |
Cancer-associated fibroblasts (CAFs) regulate cancer progression through the modulation of extracellular matrix (ECM) and cancer cell adhesion. While undergoing a series of phenotypic changes, CAFs control cancer–stroma interactions through integrin receptor signaling. Here, we isolated CAFs from patients with non-small-cell lung cancer (NSCLC) and examined their gene expression profiles. We identified collagen type XI α1 (COL11A1), integrin α11 (ITGA11), and the ITGA11 major ligand collagen type I α1 (COL1A1) among the 390 genes that were significantly enriched in NSCLC-associated CAFs. Increased ITGA11 expression in cancer stroma was correlated with a poor clinical outcome in patients with NSCLC. Increased expression of fibronectin and collagen type I induced ITGA11 expression in CAFs. The cellular migration of CAFs toward collagen type I and fibronectin was promoted via ERK1/2 signaling, independently of the fibronectin receptor integrin α5β1. Additionally, ERK1/2 signaling induced ITGA11 and COL11A1 expression in cancer stroma. We, therefore, propose that targeting ITGA11 and COL11A1 expressing CAFs to block cancer–stroma interactions may serve as a novel, promising anti-tumor strategy. © 2021 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. |
cancer; cancer-associated fibroblast; collagen type I; collagen type XI α1; integrin alpha-11; non-small-cell lung cancer; stroma interaction; transforming growth factor beta |
alpha11 integrin; collagen type 1; collagen type 1 alpha1; collagen type 11; collagen type 11 alpha1; fibronectin; fibronectin receptor; integrin; mitogen activated protein kinase 3; retrovirus vector; small interfering RNA; transforming growth factor beta1; unclassified drug; very late activation antigen 5; adult; aged; Article; cancer associated fibroblast; cancer recurrence; cell interaction; cell migration; chemotaxis; clinical article; clinical outcome; controlled study; DNA modification; enzyme linked immunosorbent assay; female; gene expression profiling; human; human cell; human tissue; immunohistochemistry; in vitro study; lung adenocarcinoma; lung fibroblast; lung parenchyma; male; non small cell lung cancer; priority journal; protein expression; protein expression level; protein |
John Wiley and Sons Ltd |
15747891 |
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33682233 |
Article |
Q1 |
2332 |
1019 |
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421 |
Teixeira J.C., Jacobs G.S., Stringer C., Tuke J., Hudjashov G., Purnomo G.A., Sudoyo H., Cox M.P., Tobler R., Turney C.S.M., Cooper A., Helgen K.M. |
56290678400;56504646300;7005875885;20435156700;8937651700;56262110300;6603548824;8699959500;55780763900;7003984281;57225849511;6602538000; |
Widespread Denisovan ancestry in Island Southeast Asia but no evidence of substantial super-archaic hominin admixture |
2021 |
Nature Ecology and Evolution |
5 |
5 |
|
616 |
624 |
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8 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102829045&doi=10.1038%2fs41559-021-01408-0&partnerID=40&md5=0f530b00ed05b700fb2df18763c0144f |
Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia; ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), The University of Adelaide, Adelaide, SA, Australia; Complexity Institute, Nanyang Technological University, Singapore, Singapore; Department of Archaeology, University of Cambridge, Cambridge, United Kingdom; Centre for Human Evolution Research, Department of Earth Sciences, Natural History Museum, London, United Kingdom; School of Mathematical Sciences, The University of Adelaide, Adelaide, SA, Australia; Statistics and Bioinformatics Group, School of Fundamental Sciences, Massey University, Palmerston North, New Zealand; Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Chronos 14Carbon-Cycle Facility, Earth and Sustainability Science Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW, Australia; ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), University of New South Wales, Sydney, NSW, Australia; South Australian Museum, Adelaide, SA, Australia; BlueSky Genetics, Ashton, SA, Australia; Australian Museum Research Institute, Australian Museum, Sydney, NSW, Australia |
Teixeira, J.C., Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), The University of Adelaide, Adelaide, SA, Australia; Jacobs, G.S., Complexity Institute, Nanyang Technological University, Singapore, Singapore, Department of Archaeology, University of Cambridge, Cambridge, United Kingdom; Stringer, C., Centre for Human Evolution Research, Department of Earth Sciences, Natural History Museum, London, United Kingdom; Tuke, J., School of Mathematical Sciences, The University of Adelaide, Adelaide, SA, Australia; Hudjashov, G., Statistics and Bioinformatics Group, School of Fundamental Sciences, Massey University, Palmerston North, New Zealand; Purnomo, G.A., Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia, Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Sudoyo, H., Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Cox, M.P., Statistics and Bioinformatics Group, School of Fundamental Sciences, Massey University, Palmerston North, New Zealand; Tobler, R., Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), The University of Adelaide, Adelaide, SA, Australia; Turney, C.S.M., Chronos 14Carbon-Cycle Facility, Earth and Sustainability Science Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), University of New South Wales, Sydney, NSW, Australia; Cooper, A., South Australian Museum, Adelaide, SA, Australia, BlueSky Genetics, Ashton, SA, Australia; Helgen, K.M., ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), University of New South Wales, Sydney, NSW, Australia, Australian Museum Research Institute, Australian Museum, Sydney, NSW, Australia |
The hominin fossil record of Island Southeast Asia (ISEA) indicates that at least two endemic ‘super-archaic’ species—Homo luzonensis and H. floresiensis—were present around the time anatomically modern humans arrived in the region >50,000 years ago. Intriguingly, contemporary human populations across ISEA carry distinct genomic traces of ancient interbreeding events with Denisovans—a separate hominin lineage that currently lacks a fossil record in ISEA. To query this apparent disparity between fossil and genetic evidence, we performed a comprehensive search for super-archaic introgression in >400 modern human genomes, including >200 from ISEA. Our results corroborate widespread Denisovan ancestry in ISEA populations, but fail to detect any substantial super-archaic admixture signals compatible with the endemic fossil record of ISEA. We discuss the implications of our findings for the understanding of hominin history in ISEA, including future research directions that might help to unlock more details about the prehistory of the enigmatic Denisovans. © 2021, The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature. |
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animal; fossil; genetics; hominid; Homo neanderthalensis; human; island (geological); Southeast Asia; Animals; Asia, Southeastern; Fossils; Hominidae; Humans; Islands; Neanderthals |
Nature Research |
2397334X |
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33753899 |
Article |
Q1 |
5822 |
225 |
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629 |
Kartika R.W., Alwi I., Reksodiputro M.H., Yunir E., Waspadji S., Immanuel S., Silalahi T., Sungkar S., Rachmat J., Bardosono S., Suyatna F.D. |
57223447932;15055173800;35090488800;36520254800;8678136400;57272979000;56275255400;57016857300;6507225348;21933841000;56039633100; |
Combination of Hyaluronic Acid with Advance-Platelet Rich Fibrin to Reduce Chronic Inflammation: a study in IL-6 and Granulation Index |
2021 |
Jordan Journal of Biological Sciences |
14 |
5 |
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983 |
989 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123993135&doi=10.54319%2fJJBS%2f140516&partnerID=40&md5=b5a893eb952c904c665bb27f1cef51cb |
Department of Surgery, Faculty of Medical and Health Science, Krida Wacana Christian University, Jakarta, Indonesia; Doctoral Program in Medical, Science Faculty of Medicine Universitas, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia — Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Department of Clinical Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Kartika, R.W., Department of Surgery, Faculty of Medical and Health Science, Krida Wacana Christian University, Jakarta, Indonesia, Doctoral Program in Medical, Science Faculty of Medicine Universitas, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia — Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Reksodiputro, M.H., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia — Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia — Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Sungkar, S., Department of Clinical Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rachmat, J., Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Type-2 Diabetes mellitus patients have risk of diabetic foot ulcers (DFUs) ranging from 15% to 25% with morbidity of 5% in the first 12 months, and the mortality rate at 5 years is around 42%. AIM: This research was conducted to study the novelty of a combining Hyaluronic Acid (HA) with Advanced Platelet Rich Fibrin (A-PRF) to reduce inflammation in DFUs healing through raising granulation index. METHODS: The study used a randomized control trial design, done from July 2019-March 2020 at Gatot Soebroto Army Hospital and Koja District Hospital, Jakarta. Subjects were DFU wound area < 40 cm2. At the start of the study all subjects received the same treatment, debridement and standard wound care. Twenty subjects were recruited according to the rule of thumb and were randomly divided into two groups namely topical A-PRF + HA (n = 10) and NaCl 0.9% (control) groups (n = 10). A part of the sample was processed into lysate and stored in -80oC. The rest is applied as a topical therapy in DFU base on intervention (A-PRF+HA or NaCl as a control). We analyzed the inflammation use swab sampling in DFU and analyze use ELISA on day- 3 and day-7. We also measured the wound area by a digital photograph and analyzed using ImageJ at the same time. RESULT: From this research, it was obtained 20 DFU subjects with Wagner 2 classification. We also performed analysis of IL-6 from swab topical DFU. A-PRF+HA group was significantly lower than NaCl (control) from swab DFU on day -3 (p = 0,,049) and day-7 (p = 0.041). In A-PRF+HA group affected on increase epithelialization process/ decrease wound area on day-3 (p = 0.016), day-7 (p = 0.048), and day-14 (p= 0.03 CONSLUSION: With the homogeneous gel formation of A-PRF + HA, it will accelerate the formation of granulation tissue compared to conventional NaCl therapy through reduce inflammation by decrease IL-6 levels. In addition, the combination A-PRF + HA has the effect of accelerating the formation of epithelialization shown by decreasing wound area in intervention group. © 2021 Jordan Journal of Biological Sciences. All Rights Reserved. |
Diabetic Foot Ulcer- Advanced Platetelet Rich Fibrin- Hyaluronic Acid-Granulation |
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Hashemite University |
19956673 |
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Article |
Q3 |
216 |
18398 |
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