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Id	Authors	Author S Id	Title	Year	Source Title	Volume	Issue	Page Start	Page End	Cited By	Link	Affiliations	Authors With Affiliations	Abstract	Author Keywords	Index Keywords	Publisher	Issn	Pubmed Id	Document Type	Sjr Best Quartile	Sjr	Sjr Rank
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656	Marwali E.M., Lopolisa A., Sani A.A., Rayhan M., Roebiono P.S., Fakhri D., Haas N.A., Slee A., Portman M.A.	36608535400;57358496100;57209881028;57219904946;57192895321;8599513100;7103216848;7004895873;7004985824;	Indonesian Study: Triiodothyronine for Infants Less than 5 Months Undergoing Cardiopulmonary Bypass	2021	Pediatric Cardiology						https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120384775&doi=10.1007%2fs00246-021-02779-8&partnerID=40&md5=ee32a32dc863edb4c293caf61a4c9fea	Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pediatric Cardiology Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Pediatric Cardiac Surgery Unit, National Cardiovascular Center Harapan Kita, Department of Cardiothoracic Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatric Cardiology and Pediatric Intensive Care, Medical Hospital of the University of Munich, Munich, Germany; Axio Research, Seattle Children’s Hospital and Research Institute, Seattle, United States; Seattle Children’s Hospital, University of Washington, Seattle, WA, United States; National Cardiovascular Center Harapan Kita, Jl. Let. Jend. S. Parman, Kav 87, Slipi, West Jakarta 11420, Indonesia	Marwali, E.M., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, National Cardiovascular Center Harapan Kita, Jl. Let. Jend. S. Parman, Kav 87, Slipi, West Jakarta 11420, Indonesia; Lopolisa, A., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Sani, A.A., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Rayhan, M., Pediatric Cardiac Intensive Care Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Roebiono, P.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Pediatric Cardiology Unit, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Fakhri, D., Pediatric Cardiac Surgery Unit, National Cardiovascular Center Harapan Kita, Department of Cardiothoracic Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Haas, N.A., Department of Pediatric Cardiology and Pediatric Intensive Care, Medical Hospital of the University of Munich, Munich, Germany; Slee, A., Axio Research, Seattle Children’s Hospital and Research Institute, Seattle, United States; Portman, M.A., Seattle Children’s Hospital, University of Washington, Seattle, WA, United States	This study evaluates the efficacy and safety of oral triiodothyronine on time to extubation for infants less than 5 months undergoing heart surgery in Indonesia, and primarily relates to patients in emerging programs with high malnutrition and mortality. In this randomized, double-blind, placebo-controlled trial, oral triiodothyronine (T3, Tetronine®) 1 μg/kg-body weight/dose or placebo (saccharum lactis) was administered via nasogastric tube every 6 h for 60 h to treatment group. A total of 120 patients were randomized into T3 (61 patients) and placebo (59 patients) groups. The majority of the patients had moderate to severe malnutrition (55.83%) with a high post-operative mortality rate of 23.3%. The T3 group showed significantly higher serum FT3 levels from 1 until 48 h post cross-clamp removal (p < 0.0001), lower incidence of low cardiac output syndrome at both 6 h (28 [45.9%] vs. 39 [66.1%] patients, p = 0.03, OR 2.3, 95% CI: 1.10–4.81) and 12 h after cross-clamp removal (25 [41.7%] vs. 36 [63.2%], p = 0.02, OR 2.40, 95% CI: 1.14–5.05). Although not statistically significant, the treatment group had shorter median (IQR) intubation time (2.59 [1.25–5.24] vs. 3.77 [1.28–6.64] days, p = 0.16, HR 1.36, 95% CI: 0.88–2.09)] and lower mortality (10 [16.4%] vs. 18 [30.5%], p = 0.07]. Patients with Aristotle score < 10.0 (low risk) receiving T3 had faster extubation than placebo patients (p = 0.021, HR of 1.90, 95% CI: 1.10–3.28) and were significantly less likely to require CPR or experience infection (p = 0.027, OR 8.56, 95% CI:0.99–73.9 and p = 0.022, OR 4.09 95% CI: 1.16–14.4, respectively). Oral T3 supplementation reduced overall incidence of low cardiac output syndrome and significantly reduced the time to extubation in low-risk patients. Therefore, prophylactic oral T3 administration may be beneficial in these patients. Trial Registration: ClinicalTrials.gov NCT02222532. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.	Congenital open cardiac surgery; Low cardiac output; Time-to-extubation; Triiodothyronine		Springer	01720643		Article	Q2	646	7791	View
667	Lesmana C.R.A., Paramitha M.S., Gani R.A., Lesmana L.A.	8977683000;57212562901;23495930300;55920139300;	The role of endoscopic ultrasound for portal hypertension in liver cirrhosis	2021	Journal of Medical Ultrasonics						https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119500644&doi=10.1007%2fs10396-021-01165-4&partnerID=40&md5=72338502ade4f82a944b72db4fee4c65	Hepatobiliary Division, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, Jakarta, Indonesia; Digestive Disease and GI Oncology Center, Medistra Hospital, Jakarta, Indonesia	Lesmana, C.R.A., Hepatobiliary Division, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, Jakarta, Indonesia, Digestive Disease and GI Oncology Center, Medistra Hospital, Jakarta, Indonesia; Paramitha, M.S., Hepatobiliary Division, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, Jakarta, Indonesia; Gani, R.A., Hepatobiliary Division, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, Jakarta, Indonesia; Lesmana, L.A., Digestive Disease and GI Oncology Center, Medistra Hospital, Jakarta, Indonesia	Chronic liver disease is still a major problem because disease progression will ultimately lead to liver cirrhosis. Portal hypertension is the hallmark in advanced liver disease management. By establishing portal vein access, endoscopic ultrasound (EUS) has been utilized in various clinical applications. In comparison to standard upper gastrointestinal endoscopy, EUS-Doppler has been shown to be a better modality for detecting esophageal and gastric varices along with peri-esophageal collateral veins, para-esophageal collateral veins, and perforating veins, and may be used to objectively predict the recurrence of bleeding. EUS-guided portal vein catheterization has also been proposed to overcome the limitations of trans-jugular approaches. The combination of EUS-elastography and azygos vein evaluation can also enhance the diagnostic accuracy of each modality. Another well-known implementation of EUS-guided procedures is in the management of ascites; particularly in paracentesis and ascitic fluid analysis. In addition, the most common clinical application of EUS in the treatment of portal hypertension is through vascular therapy or creation of intrahepatic portosystemic shunts. Major drawbacks of EUS mainly revolve around technical difficulties, the high cost of the procedure, as well as the requirement of more studies in humans to evaluate EUS-guided advanced therapeutic modalities in portal hypertension. © 2021, The Author(s), under exclusive licence to The Japan Society of Ultrasonics in Medicine.	Endoscopic ultrasound; Liver cirrhosis; Portal hypertension		Springer	13464523		Review	#N/A	#N/A	#N/A	View
736	Sulaiman A.S., Gani R.A., Hasan I., Lesmana C.R.A., Kurniawan J., Jasirwan C.O.M., Kalista K.F., Nababan S.H.H., Aprilicia G., Lesmana L.A.	57216938482;23495930300;12776850800;8977683000;57193251655;55192478000;57200425631;57205443199;57212764287;55920139300;	Overall Survival of Hepatocellular Carcinoma Patients Underwent Radiofrequency Ablation (RFA) Treatment: a Retrospective Cohort Study from Two Referral Hospitals in Indonesia	2021	Journal of Gastrointestinal Cancer						https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112279138&doi=10.1007%2fs12029-021-00676-0&partnerID=40&md5=2b5f131ccaeb172f51ae448108c59f48	Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Digestive Disease and GI Oncology Center, Medistra, Jakarta, Indonesia	Sulaiman, A.S., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Gani, R.A., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Hasan, I., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Lesmana, C.R.A., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Kurniawan, J., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Jasirwan, C.O.M., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Kalista, K.F., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Nababan, S.H.H., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Aprilicia, G., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Lesmana, L.A., Digestive Disease and GI Oncology Center, Medistra, Jakarta, Indonesia	Background: Radiofrequency ablation (RFA) is one of the curative modality therapies commonly used for the early stage of HCC management. Although numerous studies have reported the outcome of RFA around the world, the data regarding the usage of RFA for the early and intermediate stage of HCC remains limited. Hence, the study aimed to report the survival rate of the early and intermediate stage HCC patients who underwent RFA in two tertiary referral hospitals in Jakarta, Indonesia. Methods: A retrospective cohort study was conducted in Cipto Mangunkusumo and Medistra multicenter hospital in Jakarta, Indonesia. The patients with HCC BCLC A and B who underwent RFA treatments between January 2015 to December 2017 were recruited for the study. Baseline characteristics of patients were collected from the medical record. Survival analysis was calculated using the Kaplan Meier. p value result was obtained from the log-rank test. Sub-analysis of factors associated with the survival was also included in this study. Results: There were 62 patients enrolled in this study (32.3% were BCLC A and 67.7% were BCLC B). Forty-six out of 62 patients (74.2%) were reported to have RFA as their first line of treatment, while 12 (25.8%) were reported to have a combination of RFA and other therapy modalities. All these patients were follow-up with an average duration of 27 months. The survival rate of liver cancer due to HCC for 12 and 36 months in patients who received RFA was 82.3% and 57.8%, respectively. Moreover, BCLC staging of liver cancer and response after RFA was significantly associated with survival. Conclusion: RFA still can be used as initial modality therapy nor combination with another therapy for the early and intermediate stage of HCC. BCLC staging and response after RFA had shown to be the independent factors related to survival. © 2021, Springer Science+Business Media, LLC, part of Springer Nature.	Early stage and intermediate stage of liver cancer; Radiofrequency ablation; Survival rate		Springer	19416628		Article	Q3	473	10563	View
741	Sandora N., Putra M.A., Busro P.W., Ardiansyah, Muttaqin C., Makdinata W., Fitria N.A., Kusuma T.R.	57204103434;57215605850;57192273817;57223036386;57226442135;57223405655;57148498800;57222897694;	Preparation of Cell-Seeded Heart Patch In Vitro; Co-Culture of Adipose-Derived Mesenchymal Stem Cell and Cardiomyocytes in Amnion Bilayer Patch	2021	Cardiovascular Engineering and Technology						https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111590228&doi=10.1007%2fs13239-021-00565-4&partnerID=40&md5=cd6477f9e1ad4b1bf0110d68c68a71fc	Institute of Medical Education and Research Indonesia, Jakarta, 10430, Indonesia; Department of Thoracic Surgery, RSCM, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia	Sandora, N., Institute of Medical Education and Research Indonesia, Jakarta, 10430, Indonesia; Putra, M.A., Department of Thoracic Surgery, RSCM, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Busro, P.W., Department of Thoracic Surgery, RSCM, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ardiansyah, Department of Thoracic Surgery, RSCM, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muttaqin, C., Department of Thoracic Surgery, RSCM, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Makdinata, W., Department of Thoracic Surgery, RSCM, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fitria, N.A., Institute of Medical Education and Research Indonesia, Jakarta, 10430, Indonesia; Kusuma, T.R., Institute of Medical Education and Research Indonesia, Jakarta, 10430, Indonesia	Introduction: Cardiovascular disease is the second killer across the globe, while coronary disease is the major cause. Cell therapy is one alternative to regenerate the infarcted heart wall. Materials and Methods: In this study, the cardiomyogenesis capacity of human adipose stem cells (hAdSC) and human cardiomyocytes (hCardio) cultured in a 3-D biological scaffold (decellularised amnion bilayer) for nine days in a static condition was investigated. The cardiomyogenesis capacity of hAdSC were identified using immunohistochemistry and RT-PCR. The population of the cells isolated from the heart tissue expressed cTnT-1 (13.38 ± 11.38%), cKit (7.85 ± 4.2%), ICAM (85.53 ± 8.69%), PECAM (61.63 ± 7.18%) and VCAM (35.9 ± 9.11%), while from the fat tissue expressed the mesenchymal phenotypes (CD73, CD90, CD105, but not CD45, CD34, CD11b, CD19 and HLA-DR). Two age groups of hAdSC donors were compared, the youngsters (30-40yo) and the elderly (60–70 yo). Results: The co-culture showed that after 5-day incubation, the seeded graft in the hAdSC-30 group had a tube-like appearance while the hAdSC-60 group demonstrated a disorganised pattern, despite of the MSC expressions of the hAdSC-60 were significantly higher. Initial co-culture showed no difference of ATP counts among all groups, however the hAdSC-30 group had the highest ATP count after 9 days culture (p = 0.004). After normalising to the normal myocardium, only the hAdSC-60 group expressed cTnT and MHC, very low, seen during the initial cultivation, but then disappeared. Meanwhile, the hAdSC-30 group expressed α-actinin, MHC and cTnT in the Day-5. The PPAR also was higher in the Day-5 compared to the Day-9 (p < 0.005). Conclusion: Cardiomyogenesis capacity of hAdSC co-cultured with hCardio in a 3-D scaffold taken from the 30–40yo donor showed better morphology and viability than the 60-70yo group, but maintained less than 5 days in this system. © 2021, Biomedical Engineering Society.	3-D scaffold; Amnion bilayer; Human adipose stem cells; Human cardiomyocytes; Myocardial infarction	Cell culture; Heart; Stem cells; Tissue; Adipose-derived mesenchymal stem cells; Biological scaffolds; Cardio-vascular disease; Cardiomyogenesis; Coronary disease; Human adipose stem cells; Immunohistochemistry; Static conditions; Scaffolds (biology)	Springer	1869408X		Article	Q3	541	9343	View
906	Utami T.W., Putri H.M.A.R., Hellyanti T.	57195720528;57221287879;57217993236;	High Frequency of Malignant Transformations on Ovarian Mature Teratomas at a Single University Hospital, Jakarta, Indonesia (2015–2018)	2021	Journal of Obstetrics and Gynecology of India						https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098720629&doi=10.1007%2fs13224-020-01392-8&partnerID=40&md5=007db828cc36d3a44c192cdca5656bab	Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Indonesia Army Hospital, Jakarta, Indonesia; Department of Pathological Anatomy, Cipto Mangunkusumo Hospital, Jakarta, Indonesia	Utami, T.W., Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Putri, H.M.A.R., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Indonesia Army Hospital, Jakarta, Indonesia; Hellyanti, T., Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Department of Pathological Anatomy, Cipto Mangunkusumo Hospital, Jakarta, Indonesia	[No abstract available]			Springer	09719202		Article	Q3	313	14416	View
Springer Japan(4)
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264	Lesmana C.R.A., Mandasari B.K.D.	8977683000;57223222627;	The new era of endoscopic ultrasound in biliary disorders	2021	Clinical Journal of Gastroenterology	14	4	923	931		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105339459&doi=10.1007%2fs12328-021-01419-1&partnerID=40&md5=e46386a86669ce1318bf2c07a7eeb843	Division of Hepatobiliary, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, JL. Diponegoro 71, Jakarta, DKI Jakarta 10430, Indonesia; Digestive Disease & GI Oncology Centre, Medistra Hospital, Jakarta, Indonesia	Lesmana, C.R.A., Division of Hepatobiliary, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, JL. Diponegoro 71, Jakarta, DKI Jakarta 10430, Indonesia, Digestive Disease & GI Oncology Centre, Medistra Hospital, Jakarta, Indonesia; Mandasari, B.K.D., Division of Hepatobiliary, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, JL. Diponegoro 71, Jakarta, DKI Jakarta 10430, Indonesia	Biliary obstruction is one of challenging biliary disorders in gastroenterology field, where this long-standing condition can also lead to portal hypertension and multi-disciplinary teamwork is usually needed to manage this problem. Biliary drainage is the primary management to prevent prolonged cholestasis. Biliary system with its thin-walled and tubular structure sometimes makes the diagnosis and therapeutic not easy to approach. Over the past 3 decades, numerous new and modern diagnostic and therapeutic modalities have been developed to manage the complex biliary problems. It is well known that endoscopic retrograde cholangiopancreatography (ERCP), percutaneous transhepatic biliary drainage (PTBD), and surgical procedure are common procedures in managing biliary disorders. However, surgical therapy and ERCP are not always easy to perform due to several contraindications. Because of difficulty in performing these procedures or unavailability of these procedures in the facility, PTBD, as the primary non-surgical procedure of choice, has been popular due to its easy technique. Endoscopic ultrasound (EUS) has evolved significantly not only as a diagnostic tool for identification and staging, but also for interventional approaches, especially in management of biliary malignancy. Recently, EUS-guided biliary drainage (EUS-BD) and EUS-guided gallbladder drainage (EUS-GBD) are developed for managing biliary disorders. Whether EUS can be useful for managing biliary obstruction as a primary procedure is still controversial. Hence, a large number of further studies are required to validate. © 2021, Japanese Society of Gastroenterology.	Biliary obstruction; Endoscopic ultrasound (EUS); EUS-guided biliary drainage (EUS-BD); EUS-guided gallbladder drainage (EUS-GBD); Portal hypertension	biliary tract disease; biliary tract drainage; cholestasis; endoscopic retrograde cholangiopancreatography; endoscopic ultrasonography; examination; gallbladder drainage; history of medicine; human; interventional ultrasonography; nonhuman; percutaneous transhepatic drainage; portal hypertension; Review; screening; biliary tract tumor; cholestasis; diagnostic imaging; endoscopic ultrasonography; Biliary Tract Neoplasms; Cholangiopancreatography, Endoscopic Retrograde; Cholestasis; Drainage; Endosonography; Humans	Springer Japan	18657257	33895970	Review	Q3	414	11779	View
386	Oike T., Uchihara Y., Permata T.B.M., Gondhowiardjo S., Ohno T., Shibata A.	36453136000;57221723636;57197808751;6508327402;35395665700;8323572900;	Quantitative volumetric analysis of the Golgi apparatus following X-ray irradiation by super-resolution 3D-SIM microscopy	2021	Medical Molecular Morphology	54	2	166	172		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099941107&doi=10.1007%2fs00795-020-00277-z&partnerID=40&md5=67d2ba3ce4cc88d92e3e071747ee2f42	Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Jl. P. Diponegoro No. 71, Jakarta, 10430, Indonesia	Oike, T., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan, Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Uchihara, Y., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Permata, T.B.M., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Jl. P. Diponegoro No. 71, Jakarta, 10430, Indonesia; Gondhowiardjo, S., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Jl. P. Diponegoro No. 71, Jakarta, 10430, Indonesia; Ohno, T., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan, Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Shibata, A., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan	To obtain quantitative volumetric data for the Golgi apparatus after ionizing radiation (IR) using super-resolution three-dimensional structured illumination (3D-SIM) microscopy. Normal human retinal pigment epithelial (RPE) cells were irradiated with X-rays (10 Gy), followed by immunofluorescence staining of the Golgi marker RCAS1. 3D-SIM imaging was performed using DeltaVision OMX version 4 and SoftWoRx 6.1. Polygon rendering and spot signal identification were performed using Imaris 8.1.2. Differences between groups were assessed by Welch’s t test. RCAS1 signals in untreated cells were located adjacent to nuclei and showed a reticular morphology. Upon IR, the area of RCAS1 signals expanded while retaining the reticular morphology. Polygon rendering imaging revealed that the volume of RCAS1 at 48 h post-IR was greater than that for unirradiated cells (93.7 ± 19.0 μm3 vs. 33.0 ± 4.2 μm3, respectively; P < 0.001): a 2.8-fold increase. Spot signal imaging showed that the number of RCAS1 spot signals post-IR was greater than that for unirradiated cells [3.4 ± 0.8 (× 103) versus 1.3 ± 0.2 (× 103), respectively; P < 0.001]: a 2.7-fold increase. This is the first study to report quantitative volumetric data of the Golgi apparatus in response to IR using super-resolution 3D-SIM microscopy. © 2021, The Author(s).	3D-SIM; Golgi; Ionizing radiation; RCAS1; Super-resolution microscopy	article; controlled study; Golgi complex; human; human experiment; immunofluorescence; ionizing radiation; microscopy; quantitative analysis; retina pigment cell; signal transduction; vision; X irradiation; X ray; cell culture technique; epithelium cell; fluorescence microscopy; Golgi complex; procedures; radiation response; retina; three-dimensional imaging; ultrastructure; X ray; Cell Culture Techniques; Epithelial Cells; Golgi Apparatus; Humans; Imaging, Three-Dimensional; Microscopy, Fluorescence; Retina; X-Rays	Springer Japan	18601480	33501611	Article	Q2	650	7736	View
655	Ota N., Yoshimoto Y., Darwis N.D.M., Sato H., Ando K., Oike T., Ohno T.	57359393800;36453407100;57200045716;55697961900;55641963900;36453136000;35395665700;	High tumor mutational burden predicts worse prognosis for cervical cancer treated with radiotherapy	2021	Japanese Journal of Radiology						https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120410945&doi=10.1007%2fs11604-021-01230-5&partnerID=40&md5=4f3db9b90e6b959382e2d0ca7b994c0b	Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Department of Radiation Oncology, School of Medicine, Fukushima Medical University, 1, Hikarigaoka, Fukushima, 960-1295, Japan; Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jl. Diponegoro No. 71, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan	Ota, N., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Yoshimoto, Y., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan, Department of Radiation Oncology, School of Medicine, Fukushima Medical University, 1, Hikarigaoka, Fukushima, 960-1295, Japan; Darwis, N.D.M., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan, Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jl. Diponegoro No. 71, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Sato, H., Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Ando, K., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Oike, T., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan, Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Ohno, T., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan, Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan	Purpose: Tumor mutational burden (TMB) is a surrogate biomarker of neo-antigens and high TMB status is associated with favorable response to immune-checkpoint inhibitors (ICIs). This study aimed to elucidate the association between TMB and the outcome of definitive radiotherapy in patients with cervical cancer. Materials and methods: TMB and treatment outcome were retrospectively analyzed in patients with newly diagnosed cervical cancer treated with definitive radiotherapy available with somatic mutation data of pre-treatment tumors obtained using a commercially available gene panel. Results: The study enrolled 98 patients (median follow-up period, 61 months). The median TMB was 9.5 mutations per megabase (range, 3.0–35.5 mutations per megabase). After dichotomization based on this median value, the 5-year overall survival (OS) for TMB-high patients was significantly worse than that of TMB-low patients (61.1% vs. 82.2%). Multivariate analysis identified high TMB status as a significant prognostic factor for worse OS, along with advanced stage, para-aortic lymph node involvement, and absence of concurrent chemotherapy. Conclusion: These data indicate that TMB is a potential prognostic factor for worse survival in patients with cervical cancer treated with definitive radiotherapy, thereby providing a rationale for treatment of TMB-high cervical cancers with a combination of ICIs plus radiotherapy. Secondary abstract: This retrospective study of 98 patients demonstrates for the first time that tumor mutational burden (TMB) is an independent prognostic factor for worse overall survival of patients treated with definitive radiotherapy, providing a rationale for treatment of TMB-high cervical cancers with a combination of immune-checkpoint inhibitors plus radiotherapy. © 2021, The Author(s).	Cervical cancer; Prognosis; Radiotherapy; Tumor mutational burden		Springer Japan	18671071		Article	Q2	616	8208	View
917	Aziza Y., Inatomi T., Sotozono C., Kinoshita S.	57214455776;7003842530;7003976484;7402391671;	Pterygium excision with modified bare sclera technique combined with mitomycin C	2021	Japanese Journal of Ophthalmology	65	1	89	96	1	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096149087&doi=10.1007%2fs10384-020-00786-5&partnerID=40&md5=184828afad7b83063fe2f20bcb75744d	Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan; Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Ophthalmology, National Center for Geriatrics and Gerontology, Aichi, Japan; Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan	Aziza, Y., Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan, Department of Ophthalmology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Inatomi, T., Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan, Department of Ophthalmology, National Center for Geriatrics and Gerontology, Aichi, Japan; Sotozono, C., Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto, 602-0841, Japan; Kinoshita, S., Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan	Purpose: Numerous surgical methods, with varying rates of recurrence, have been applied for the treatment of pterygium. Adjuvant mitomycin C (MMC) application has shown promising results in the prevention of recurrence. Here we propose and describe modified bare sclera technique combined with the intraoperative application of MMC for pterygium excision. Study design: Retrospective study. Methods: Primary pterygium patients who underwent pterygium excision via the bare sclera combined with 0.04% MMC technique from January 2014 to December 2016 were reviewed. In all patients, the subconjunctival pterygium strand was exposed and then sufficiently excised in combination with the safe use of MMC; i.e., the prevention of MMC dilution and diffusion to surrounding tissue. Surgical complications, recurrence rates, and recurrence onset were recorded. Results: This study involved 32 primary pterygium eyes (grade T1 = 22 eyes; 68.7%). The mean postoperative follow-up period was 26.4 ± 14.5 months (range: 12–60 months). MMC was applied for 1–3 min. The mean complete epithelialization was 12.6 ± 7.6 days and no surgical complications were observed. In 1 patient with double-head primary pterygium, recurrence occurred at 15-months postoperative. Conclusions: The modified bare sclera technique combined with MMC application was found to be safe, effective, and presents good cosmetic appearance for the treatment of primary pterygium when safety points are strictly applied. © 2020, Japanese Ophthalmological Society.	Bare sclera with MMC; Recurrence rate; Safety profile	betamethasone; levofloxacin; mitomycin; oxybuprocaine; mitomycin; adult; aged; Article; controlled study; diffusion; dilution; drug safety; epithelization; eye surgery; female; follow up; human; intraoperative period; Japan; major clinical study; male; medical record review; modified bare sclera technique; optical coherence tomography; patient; postoperative complication; postoperative period; priority journal; pterygium; recurrent disease; retrospective study; surgical technique; university hospital; conjunctiva; pterygium; sclera; treatment outcome; Conjunctiva; Follow-Up Studies; Humans; Mitomycin; Pterygium; Recurrence; Retrospective Studies; Sclera; Treatment Outcome	Springer Japan	00215155	33205316	Article	Q2	934	4846	View
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219	Amarra M.S., Chong M.F.-F., Titapant V., Somprasit C., Rogacion J., Irwinda R., Huynh T.N.K., Nalliah S.	26024123300;16302916300;6602085502;8440614700;6508291071;57205713130;57221814418;25422423000;	ILSI Southeast Asia symposium: prevalence, risk factors, and actions to address gestational diabetes in selected Southeast Asian countries	2021	European Journal of Clinical Nutrition	75	9	1303	1308		https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100287487&doi=10.1038%2fs41430-020-00838-6&partnerID=40&md5=968eff6db95c2d745843171831db19e3	Department of Food Science and Nutrition, College of Home Economics, University of the Philippines Diliman, Quezon, Philippines; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore; Department of Obstetrics and Gynecology, Faculty of Medicine, Siriraj Hospital Mahidol University, Bangkok, Thailand; Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Bangkok, Thailand; Department of Pediatrics, University of the Philippines, Manila, Philippines; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Pham Ngoc Thach University of Medicine, Ho Chi Minh, Viet Nam; Division of Obstetrics & Gynaecology, Clinical School, International Medical University, Seremban, Malaysia	Amarra, M.S., Department of Food Science and Nutrition, College of Home Economics, University of the Philippines Diliman, Quezon, Philippines; Chong, M.F.-F., Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore; Titapant, V., Department of Obstetrics and Gynecology, Faculty of Medicine, Siriraj Hospital Mahidol University, Bangkok, Thailand; Somprasit, C., Department of Obstetrics and Gynecology, Faculty of Medicine, Thammasat University, Bangkok, Thailand; Rogacion, J., Department of Pediatrics, University of the Philippines, Manila, Philippines; Irwinda, R., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Huynh, T.N.K., Department of Obstetrics and Gynecology, Pham Ngoc Thach University of Medicine, Ho Chi Minh, Viet Nam; Nalliah, S., Division of Obstetrics & Gynaecology, Clinical School, International Medical University, Seremban, Malaysia	[No abstract available]		trace element; anthropometry; Brunei Darussalam; Cambodia; diet therapy; dietary intake; female; gestational weight gain; health care planning; human; Indonesia; Laos; Malaysia; Myanmar; nutritional assessment; Philippines; physical activity; practice guideline; pregnancy diabetes mellitus; prevalence; Review; risk factor; risk reduction; Singapore; Southeast Asian; symposium; Thailand; Viet Nam; pregnancy; pregnancy diabetes mellitus; Southeast Asia; Asia, Southeastern; Diabetes, Gestational; Female; Humans; Pregnancy; Prevalence; Risk Factors	Springer Nature	09543007	33531635	Review	Q1	1024	4241	View

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