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No records
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583 |
Solichin I., Martika W., Wikanjaya R. |
57202813479;57221741247;57211909508; |
Giant cell tumor of distal ulna treated using en-bloc resection combined with extensor carpi ulnaris and flexor carpi ulnaris tendon stabilization: A case report |
2021 |
International Journal of Surgery Case Reports |
79 |
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362 |
367 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100064170&doi=10.1016%2fj.ijscr.2021.01.065&partnerID=40&md5=ece16a895e1dc0497c6813f32864cdda |
Department of Orthopaedics and Traumatology, Purwokerto Orthopaedics Hospital, Purwokerto, Central Java, Indonesia; Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo National Central General Hospital – Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Solichin, I., Department of Orthopaedics and Traumatology, Purwokerto Orthopaedics Hospital, Purwokerto, Central Java, Indonesia; Martika, W., Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo National Central General Hospital – Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wikanjaya, R., Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo National Central General Hospital – Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Giant Cell Tumor (GCT) is a form of bone tumor which is rare, benign, and locally invasive. To date, there have not been many case reports regarding cases of GCTs on the distal ulna which made the optimum strategy in management remain controversial. In some reported cases, the patient was treated with wide excision followed by reconstructive procedure resulting in ulnar translation of the carpal bones and dynamic convergence of the ulna towards the radius. Presentation of case: We documented a case of 29-year-old male with distal ulna GCT, treated with en-bloc resection combined with extensor carpi ulnaris and flexor carpi ulnaris tendon stabilization. The key objectives of GCT treatments are to avoid local recurrence with sufficient resection and to maintain the function of the limbs. Specific treatment options have been suggested for en-bloc resection with or without the need for ulnar reconstruction or stabilization, even prothesis. In this case, we excised the distal portion of the ulna with some soft tissue procedure for added stability. Clinical discussion: Three weeks after the surgery, the patient was able to perform wrist flexion and extension, fingers abduction, adduction, and opposition with slight limitation. The DASH and PRWE score had improved gradually within 3 weeks and 6 months after the surgery. Conclusion: In the subsequent evaluation after six months of the surgery, the patient achieved full restoration of forearm function without any limitation. © 2021 The Authors |
Distal ulna; En-bloc resection; GCT; Giant cell tumor of bone |
liquid nitrogen; methacrylic acid methyl ester; phenol; poly(methyl methacrylate); abduction; adduction; adult; arm swelling; Article; bone remodeling; bone transplantation; cancer size; cancer surgery; case report; clinical article; cryotherapy; curettage; Disabilities of the Arm, Shoulder and Hand (score); disability severity; distal ulna; en bloc resection; histopathology; human; human cell; human tissue; joint limitation; male; massage; nuclear magnetic resonance imaging; orthopedic surgery; osteoclastoma; Patient Rated Wrist Evaluation; priority journal; radius; recurrent disease; right handedness; soccer; sport injury; tendon surgery; tumor biopsy; wide excision; wrist pain; wrist radiography |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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584 |
Pontoh L.A., Dilogo I.H., Hartono F., Rhatomy S., Fiolin J. |
57192907426;56161962800;57192910622;57204509883;57194498274; |
Meniscal bearing dislocation following minimally invasive Oxford medial unicompartmental knee arthroplasty treated with simple open reduction: Case report |
2021 |
International Journal of Surgery Case Reports |
79 |
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371 |
374 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100038635&doi=10.1016%2fj.ijscr.2021.01.057&partnerID=40&md5=242712f5a82b08a469e3cb507ff4eee4 |
Department of Orthopaedic and Traumatology, Fatmawati General Hospital, Faculty of Medicine Universitas Indonesia, Jl. RS Fatmawati no. 4, Jakarta Selatan, 12430, Indonesia; Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro no. 71, Jakarta Pusat, 10430, Indonesia; Orthopaedic Center Pantai Indah Kapuk Hospital, Jl. Pantai Indah Utara 3, Jakarta Utara, Jakarta 14460, Indonesia; Orthopaedic Department, Soeradji Tirtonegoro Hospital, Faculty of Medicine, Public Health of Nursing, Universitas Gadjah Mada, Klaten, Yogyakarta, Indonesia; Jakarta Knee, Shoulder and Orthopaedic Sport Clinic, Pondok Indah Hospital, Jl. Metro Duta Kav UE, Jakarta, 12310, Indonesia |
Pontoh, L.A., Department of Orthopaedic and Traumatology, Fatmawati General Hospital, Faculty of Medicine Universitas Indonesia, Jl. RS Fatmawati no. 4, Jakarta Selatan, 12430, Indonesia; Dilogo, I.H., Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro no. 71, Jakarta Pusat, 10430, Indonesia; Hartono, F., Orthopaedic Center Pantai Indah Kapuk Hospital, Jl. Pantai Indah Utara 3, Jakarta Utara, Jakarta 14460, Indonesia; Rhatomy, S., Orthopaedic Department, Soeradji Tirtonegoro Hospital, Faculty of Medicine, Public Health of Nursing, Universitas Gadjah Mada, Klaten, Yogyakarta, Indonesia; Fiolin, J., Jakarta Knee, Shoulder and Orthopaedic Sport Clinic, Pondok Indah Hospital, Jl. Metro Duta Kav UE, Jakarta, 12310, Indonesia |
Introduction: Dislocation of polyethylene insert is one of the most common complications of mobile bearing-medial unicompartmental knee arthroplasty (MUKA). Bearing dislocation was diagnosed by radiograph examination in these cases upon trivial injury. Case presentation: We reported one case of meniscal bearing dislocation after an Oxford MUKA treated with a simple open reduction technique. Clinical discussion: Simple open reduction surgery without change of the bearing and the use of knee brace for 6 months was effective in preventing re-dislocation. Conclusion: Mobile bearing dislocation is one of the most common complications in mobile-bearing MUKA. Besides the prevention of technical errors, usage of UKA with a frequency of 10–15 per year is recommended to increase the surgeon's learning curve. © 2021 The Authors |
Case report; Medial knee osteoarthritis (KOA); Mobile bearing dislocation; Oxford medial unicompartmental knee arthroplasty (MUKA) |
adult; Article; case report; clinical article; female; human; knee arthroplasty; knee dislocation; knee osteoarthritis; knee pain; meniscal bearing dislocation; middle aged; minimally invasive surgery; mobile bearing medial unicompartmental knee arthroplasty; open reduction (procedure); priority journal; X ray |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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587 |
Verdian H., Dilogo I.H. |
57221635771;56161962800; |
Early total care in polytrauma patient with floating shoulder and occlusion of bilateral subclavian artery: A case report |
2021 |
International Journal of Surgery Case Reports |
79 |
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312 |
317 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099650882&doi=10.1016%2fj.ijscr.2021.01.041&partnerID=40&md5=5d572ddcabe10c5cefb738039532c560 |
Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Verdian, H., Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Dilogo, I.H., Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: Fracture in polytrauma patients have higher risk of morbidity and mortality compared to those found in monotrauma patients. The ideal approach of orthopaedic injuries is to perform definitive fixation of all fractures in one single procedure, an approach known as Early Total Care (ETC). Presentation of case: A patient presented with history of being struck by heavy material forklift. He complained of pain in the shoulder and difficulty in breathing. The patient was diagnosed with polytrauma ISS Score 25, which consists of floating shoulder, closed fracture of multiple ribs, open hematopneumothorax, and thrombosis of subclavian artery. The following procedures were performed: debridement, ORIF plate and screw of right clavicle, ORIF lag screw of right glenoid scapula, thoracotomy segmental lobectomy, bypass of bilateral carotid artery to bilateral brachial artery. Discussion: An early surgical treatment is paramount in the management of this patient, with the aim of restoring the joint and blood flow to the distal part of the hand, which will allow for early motion and more effective physiotherapy for the patient'srecovery. Early definitive fracture fixation in ETC in recommended in for stable patients and those who falls under the category of borderline and unstable patients who responds well to resuscitation. ETC allows for early mobilization and therapies for the patient. Conclusion: Early total care is an appropriate choice of treatment for polytrauma patients presenting with floating shoulder. © 2021 |
Early total care; Floating shoulder |
artery occlusion; artery thrombosis; Article; brachial artery; carotid artery; case report; clavicle; clinical article; debridement; floating shoulder; hematopneumothorax; human; lung lobectomy; male; multiple trauma; priority journal; rib fracture; scapula; shoulder disease; subclavian artery; thoracotomy; X ray |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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588 |
Lubis A.M.T., Oktari P.R. |
15122639800;57221621417; |
Arthroscopic Bankart revision using all suture anchor in recurrent anterior shoulder dislocation: A case report |
2021 |
International Journal of Surgery Case Reports |
79 |
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291 |
294 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099634995&doi=10.1016%2fj.ijscr.2021.01.023&partnerID=40&md5=3fa158fccff45a5373eb4d306d596cb7 |
Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta 10430, Indonesia |
Lubis, A.M.T., Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta 10430, Indonesia; Oktari, P.R., Department of Orthopedic & Traumatology, Cipto Mangunkusumo Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta 10430, Indonesia |
Introduction: Arthroscopic Bankart revision after recurrent shoulder dislocation is still a matter of discussion. Several factors are contributing to this injury. Recently the development of all suture anchors has grown in popularity in arthroscopic stabilization. It was proven to preserve bone stock, smaller in size thus more anchors can be made. Presentation of case: We presented a case of 27-year-old woman with recurrent anterior dislocation after seven years of arthroscopic Bankart repair. Seven years before, we performed Bankart repair using three 2.8 mm fiber-wire anchor (FASTak® (Arthrex, Karsfield Germany)). For the revision surgery we performed arthroscopic revision using four all suture anchor technique (Y-Knot® Flex All-Suture Anchor, 1.3 mm – One strand of #2 Hi-Fi® (Conmed, New York)). Discussion: From preoperative and intraoperative assessment, we found no anchor failure and no massive bony lesion. To preserve the bone stock we insert four all suture anchors between the old anchor. One year post-operative follow up showed that patient could gain normal range of movement. No early or late complications were observed. Conclusion: Compared to the conventional metallic anchor, all suture anchor has the same biomechanical strength. Moreover due to its relatively small size, it can reserve bone stock and more anchors can be made thus adding more stability to the shoulder. © 2021 The Authors |
All suture anchor; Arthroscopic Bankart repair; Recurrent dislocation of shoulder |
adult; arthroscopic surgery; Article; Bankart lesion; case report; clinical article; computer assisted tomography; female; fracture healing; general anesthesia; human; isometric exercise; nuclear magnetic resonance imaging; passive movement; physical examination; priority journal; range of motion; recurrent shoulder dislocation; reoperation; rotator cuff; shoulder radiography |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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589 |
Darwis P., Limengka Y., Muradi A., Telaumbanua R.S., Karina |
57221617760;37029815800;55481732200;57221620281;57224491598; |
Endoluminal dilatation technique to remove stuck hemodialysis tunneled catheter: A case report from Indonesia |
2021 |
International Journal of Surgery Case Reports |
79 |
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248 |
250 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099630922&doi=10.1016%2fj.ijscr.2021.01.029&partnerID=40&md5=b099b1757dbbb61be8d74e5584792f13 |
Vascular and Endovascular Division, Surgery Department, Faculty of Medicine University of Indonesia /National General Hospital dr Cipto Mangunkusumo, Jakarta, Indonesia |
Darwis, P., Vascular and Endovascular Division, Surgery Department, Faculty of Medicine University of Indonesia /National General Hospital dr Cipto Mangunkusumo, Jakarta, Indonesia; Limengka, Y., Vascular and Endovascular Division, Surgery Department, Faculty of Medicine University of Indonesia /National General Hospital dr Cipto Mangunkusumo, Jakarta, Indonesia; Muradi, A., Vascular and Endovascular Division, Surgery Department, Faculty of Medicine University of Indonesia /National General Hospital dr Cipto Mangunkusumo, Jakarta, Indonesia; Telaumbanua, R.S., Vascular and Endovascular Division, Surgery Department, Faculty of Medicine University of Indonesia /National General Hospital dr Cipto Mangunkusumo, Jakarta, Indonesia; Karina, Vascular and Endovascular Division, Surgery Department, Faculty of Medicine University of Indonesia /National General Hospital dr Cipto Mangunkusumo, Jakarta, Indonesia |
Background: Tunneled CVC is being increasingly used worldwide as a mean of vascular access for hemodialysis. Among these, one of the emerging complications is that of the “embedded” or stuck catheter. There have been registered cases of vasomotor collapse, non-ST-elevation myocardial infarction (NSTEMI), avulsion of the vena cava, damage to the tricuspid valve having fatal consequences, and breakage of the CVC (Lodi et al., 2016). Case presentation: A 63-year-old female with mature AV fistula came to the clinic for removal of a tunnelled 15 fr double lumen dialysis catheter (Medical Components, Harleysville, Pensylvania) that had been inserted into the left internal jugular vein 15 months prior to this visit. In the OR, our surgical attempt to remove the catheter failed. The first few dilation procedures were performed using 0.035-inch guidewire and balloon catheters. The technique was subsequently modified as follows. In this case we use a 6 × 60 mm Scoreflex balloon. Endoluminal dilation was repeated along the length of the catheter up to the cuff. Once the catheter has been removed, pressure was applied using sterile gauze to aid hemostasis. The procedure was successful without any observed complication. Conclusion: Endoluminal dilatation technique is considered as the easiest and safest technique to remove hemodialysis catheter. Our case is the first stuck hemodialysis catheter reported in Indonesia and probably the first case that happen and treat with endoluminal dilatation technique in our country. © 2021 The Author(s) |
Endoluminal dilatation; Hemodialysis; Stuck tunneled catheter |
adult; arteriovenous fistula; Article; case report; catheter removal; clinical article; endoluminal dilatation technique; female; hemostasis; human; Indonesia; middle aged; priority journal |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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591 |
Rahayatri T.H., Pramudito B.C., Soedibyo S. |
57188549965;57221381023;57216931706; |
Vaginal reconstruction using ileum segment and posterior sagittal anorectoplasty in a patient with Mayer–Rokitansky–Küster–Hauser syndrome with anorectal malformations: A case report |
2021 |
International Journal of Surgery Case Reports |
79 |
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76 |
83 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098963856&doi=10.1016%2fj.ijscr.2020.12.085&partnerID=40&md5=c4c60b2bb5126615110a09f813253345 |
Faculty of Medicine, Universitas Indonesia, Department of Pediatric Surgery, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Department of Surgery, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Rahayatri, T.H., Faculty of Medicine, Universitas Indonesia, Department of Pediatric Surgery, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pramudito, B.C., Faculty of Medicine, Universitas Indonesia, Department of Surgery, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Soedibyo, S., Faculty of Medicine, Universitas Indonesia, Department of Pediatric Surgery, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Vaginal agenesis with anorectal malformations is a complex pediatric condition that adversely affects various physiological processes in the body. It may cause disturbances in defecation and urination, abnormalities in the urinary and gastrointestinal tract, dysfunction of the genital and reproductive organs, and sexual function disorders. The complexity in the surgical management of vaginal agenesis includes the selection of a functional reconstruction technique for anal and vaginal formation, timing of the reconstruction, and management of complications in the associated organ system. Herein, we describe a patient with Mayer–Rokitansky–Küster–Hauser syndrome accompanied by a rectovesical fistula. Other abnormalities, such as microcephaly, polydactyly, long urethral abnormalities resembling the male urethra, and complications in the kidney and urinary tract, were observed in the patient. The associated complications included recurrent urinary tract infections, urinary overflow incontinence, vesicoureteric reflux, hydroureter, and left renal hydronephrosis. The patient underwent posterior sagittal anorectoplasty surgery and vaginal reconstruction. The long-term vaginal physiological development of patients with this condition remains unknown. © 2020 |
Anorectal malformation; MRKH syndrome; Vaginal agenesis |
adult; anorectal malformation; Article; case report; clinical article; female; human; hydronephrosis; hydroureter; ileum; intestine surgery; microcephaly; polydactyly; posterior sagittal anorectoplasty; priority journal; rectovesical fistula; recurrent disease; Rokitansky syndrome; urethra malformation; urinary tract infection; urine incontinence; vagina reconstruction; vesicoureteral reflux |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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No records
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6 |
Pranata R., Huang I., Lim M.A., Yonas E., Vania R., Lukito A.A., Nasution S.A., Siswanto B.B., Kuswardhani R.A.T. |
57201973901;57208576645;57216039756;57201987097;57208328436;57213835420;57189373134;14422648800;36863900500; |
Elevated De Ritis Ratio Is Associated With Poor Prognosis in COVID-19: A Systematic Review and Meta-Analysis |
2021 |
Frontiers in Medicine |
8 |
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676581 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122327729&doi=10.3389%2ffmed.2021.676581&partnerID=40&md5=254957cc5c17b448a803a88e33741d8f |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Faculty of Medicine, Department of Internal Medicine, Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Faculty of Medicine, Division of Plastic, Reconstructive, and Aesthetic, Department of Surgery, Sanglah General Hospital, Udayana University, Jimbaran, Indonesia; Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Faculty of Medicine, Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Division of Geriatrics, Department of Internal Medicine, Sanglah Teaching Hospital, Udayana University, Denpasar, Indonesia |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Huang, I., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Faculty of Medicine, Department of Internal Medicine, Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Faculty of Medicine, Division of Plastic, Reconstructive, and Aesthetic, Department of Surgery, Sanglah General Hospital, Udayana University, Jimbaran, Indonesia; Lukito, A.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Nasution, S.A., Faculty of Medicine, Division of Cardiology, Department of Internal Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siswanto, B.B., Faculty of Medicine, Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia, Jakarta, Indonesia; Kuswardhani, R.A.T., Faculty of Medicine, Division of Geriatrics, Department of Internal Medicine, Sanglah Teaching Hospital, Udayana University, Denpasar, Indonesia |
Objective: This meta-analysis aims to assess whether elevated De Ritis ratio is associated with poor prognosis in patients with coronavirus 2019 (COVID-19). Methods: A systematic literature search was performed using PubMed, Embase, and EuropePMC databases up until September 17, 2021. De Ritis ratio is also known as Aspartate aminotransferase/alanine transaminase (AST/ALT) ratio. The main outcome was poor prognosis, a composite of mortality, severity, the need for ICU care, and intubation. The effect measure was odds ratios (ORs) and mean differences. We generated sensitivity and specificity, negative and positive likelihood ratio (NLR and PLR), diagnostic odds ratio (DOR), and area under curve (AUC). Results: There were eight studies with 4,606 patients. De Ritis ratio was elevated in 44% of the patients. Patients with poor prognosis have higher De Ritis ratio [mean difference 0.41 (0.31, 0.50), p < 0.001; I2: 81.0%] and subgroup analysis showed that non-survivors also have higher De Ritis Ratio [mean difference 0.47 (0.46, 0.48), p < 0.001; I2: 0%]. Elevated De Ritis ratio was associated with poor prognosis [OR 3.28 (2.39, 4.52), p < 0.001; I2: 35.8%]. It has a sensitivity of 55% (36–73), specificity of 71% (52–85), PLR 1.9, NLR.63, DOR of 3 (2–4), and AUC of.67 (0.63–0.71). The posterior probability of poor prognosis was 38% if De Ritis is elevated, while 17% if De Ritis is not elevated. Conclusion: Elevated De Ritis ratio is associated with poor prognosis in patients with COVID-19. Systematic Review Registration: PROSPERO ID: CRD42020216634. Copyright © 2021 Pranata, Huang, Lim, Yonas, Vania, Lukito, Nasution, Siswanto and Kuswardhani. |
coronavirus—COVID-19; De Ritis ratio; liver enzyme; SARS-CoV-2; transaminase |
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Frontiers Media S.A. |
2296858X |
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Review |
Q1 |
1388 |
2608 |
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10 |
Lee Y.-S., Oh Y.S., Choi E.-K., Chern A.K.C., Jiampo P., Chutinet A., Hanafy D.A., Trivedi P., Zhai D. |
57369401600;14021940000;35558194200;57219941181;57219936937;15724336700;55431326800;57219936294;57219941292; |
Patient perception and treatment convenience of dabigatran versus vitamin K antagonist when used for stroke prophylaxis in atrial fibrillation: Real-world Evaluation of Long-term Anticoagulant Treatment Experience (RE-LATE) study |
2021 |
Open Heart |
8 |
2 |
e001745 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121029837&doi=10.1136%2fopenhrt-2021-001745&partnerID=40&md5=604033aab18ff9417453572cb72e2905 |
Department of Internal Medicine, Daegu Catholic University College of Medicine, Daegu, South Korea; Department of Internal Medicine, Catholic University of Korea, Seoul, South Korea; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea; Department of Cardiology, Columbia Asia Hospital, Taiping, Malaysia; Department of Medicine, Bhumibol Adulyadej Hospital, Bangkok, Thailand; Chulalongkorn Stroke Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Division of Neurology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand; Cardiology and Vascular Medicine, Pusat Jantung Nasional Harapan Kita, Jakarta, Indonesia; Cardiology and Vascular Medicine, University of Indonesia Faculty of Medicine, Jakarta, Indonesia; Boehringer Ingelheim Singapore Pte Ltd, Singapore, Singapore; Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, United States |
Lee, Y.-S., Department of Internal Medicine, Daegu Catholic University College of Medicine, Daegu, South Korea; Oh, Y.S., Department of Internal Medicine, Catholic University of Korea, Seoul, South Korea; Choi, E.-K., Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea; Chern, A.K.C., Department of Cardiology, Columbia Asia Hospital, Taiping, Malaysia; Jiampo, P., Department of Medicine, Bhumibol Adulyadej Hospital, Bangkok, Thailand; Chutinet, A., Chulalongkorn Stroke Center, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, Division of Neurology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand; Hanafy, D.A., Cardiology and Vascular Medicine, Pusat Jantung Nasional Harapan Kita, Jakarta, Indonesia, Cardiology and Vascular Medicine, University of Indonesia Faculty of Medicine, Jakarta, Indonesia; Trivedi, P., Boehringer Ingelheim Singapore Pte Ltd, Singapore, Singapore; Zhai, D., Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, United States |
Purpose Dabigatran is a direct thrombin inhibitor approved for stroke prophylaxis in patients with non-valvular atrial fibrillation (NVAF). Real-world data about patient preference, satisfaction and convenience in patients in Asia are not available. The study aimed to explore the perception of patients with newly diagnosed NVAF regarding dabigatran versus vitamin K antagonists (VKAs), when used for stroke prevention. Patients and methods This was a multinational, multicentre, non-interventional study involving 49 sites across 5 countries in South East Asia and South Korea where 934 patients newly diagnosed with NVAF were initiated on either dabigatran (N=591) or VKA (N=343). Data were collected at baseline and over two follow-up visits across 6 months. Treatment satisfaction and patient convenience were evaluated using the Perception on Anticoagulant Treatment Questionnaire-2 (PACT-Q2). Results The mean age of the patients was 65.9±10.4 years, and 64.2% were male. Mean CHA 2 DS 2-VASc score was 2.4±1.5, and mean HAS-BLED score was 1.2±0.9. At baseline, patients initiated on dabigatran had higher stroke risk, bleeding risk, creatinine clearance and proportion of patients with concomitant illnesses compared with patients initiated on VKAs. Treatment convenience was perceived to be significantly better with dabigatran versus VKAs at visits 2 and 3 (p=0.0423 and 0.0287, respectively). Treatment satisfaction was significantly better with dabigatran compared with VKAs at visit 3 (p=0.0300). Conclusion In this study, dabigatran is associated with better patient perception in terms of treatment convenience and satisfaction compared with VKAs when used for stroke prevention in newly diagnosed NVAF patients from South East Asia and South Korea. Plain language summary Patient satisfaction with dabigatran versus VKAs in South East Asia. Patients with atrial fibrillation are at high risk of stroke and require anticoagulants for stroke prevention. Two such anticoagulants are dabigatran and VKAs. We wanted to compare the extent of satisfaction and treatment convenience among newly diagnosed patients with atrial fibrillation from the South East Asian region when they were given either dabigatran or VKAs. Consenting patients filled out a standardised questionnaire called the PACT-Q2 over three visits after they were started on either dabigatran (591 patients) or VKAs (343 patients). We found that satisfaction and convenience were significantly higher when patients received dabigatran than when they received VKAs. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
Atrial fibrillation; Health care; Outcome assessment; Stroke |
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BMJ Publishing Group |
2398595X |
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Q1 |
1050 |
4080 |
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81 |
Raharja A., Tamara A., Kok L.T. |
57192080346;57205305387;57219901696; |
Association Between Ethnicity and Severe COVID-19 Disease: a Systematic Review and Meta-analysis |
2021 |
Journal of Racial and Ethnic Health Disparities |
8 |
6 |
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1563 |
1572 |
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8 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096023866&doi=10.1007%2fs40615-020-00921-5&partnerID=40&md5=139e8ff070e1e792a6383269e01b7342 |
Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Raharja, A., Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom; Tamara, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kok, L.T., Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom |
Objectives: This article evaluates if ethnicity is an independent poor prognostic factor in COVID-19 disease. Methods: MEDLINE, EMBASE, Cochrane, WHO COVID-19 databases from inception to 15/06/2020 and medRxiv. No language restriction. Newcastle-Ottawa Scale (NOS) and GRADE framework were utilised to assess the risk of bias and certainty of evidence. PROSPERO CRD42020188421. Results: Seventy-two articles (59 cohort studies with 17,950,989 participants, 13 ecological studies; 54 US-based, 15 UK-based; 41 peer-reviewed) were included for systematic review and 45 for meta-analyses. Risk of bias was low: median NOS 7 of 9 (interquartile range 6–8). Compared to White ethnicity, unadjusted all-cause mortality was similar in Black (RR: 0.96 [95% CI: 0.83–1.08]) and Asian (RR: 0.99 [0.85–1.16]) but reduced in Hispanic ethnicity (RR: 0.69 [0.57–0.84]). Age- and sex-adjusted risks were significantly elevated for Black (HR: 1.38 [1.09–1.75]) and Asian (HR: 1.42 [1.15–1.75]), but not for Hispanic (RR: 1.14 [0.93–1.40]). Further adjusting for comorbidities attenuated these associations to non-significance: Black (HR: 0.95 [0.72–1.25]); Asian (HR: 1.17 [0.84–1.63]); Hispanic (HR: 0.94 [0.63–1.44]). Subgroup analyses showed a trend towards greater disparity in outcomes for UK ethnic minorities, especially hospitalisation risk. Conclusions: This review could not confirm a certain ethnicity as an independent poor prognostic factor for COVID-19. Racial disparities in COVID-19 outcomes may be partially attributed to higher comorbidity rates in certain ethnicity. © 2020, W. Montague Cobb-NMA Health Institute. |
Acute kidney injury; COVID-19; Ethnicity; Hospitalisation; Intubation; Mortality |
ethnicity; ethnology; human; meta analysis; patient acuity; prognosis; risk factor; therapy; COVID-19; Ethnicity; Humans; Patient Acuity; Prognosis; Risk Factors |
Springer Science and Business Media Deutschland GmbH |
21973792 |
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33180278 |
Review |
Q1 |
644 |
7820 |
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175 |
Tamba R.P., Moenadjat Y. |
47761736600;57190371576; |
Oral Spermine Supplementation in Gestated Rabbit: A Study on Villi Height of Immature Intestines |
2021 |
Frontiers in Surgery |
8 |
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721560 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115713070&doi=10.3389%2ffsurg.2021.721560&partnerID=40&md5=ef2b810fab926ddb3b4313b8d20045f5 |
Faculty of Medicine, Department of Surgery Cipto, Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Tamba, R.P., Faculty of Medicine, Department of Surgery Cipto, Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Moenadjat, Y., Faculty of Medicine, Department of Surgery Cipto, Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Immature intestines are the major problem in prematurity. Postnatal oral spermine has been shown in studies to improve intestinal maturation in rats and piglets. This study aimed to find out the efficacy of spermine in rabbits during gestation. Method: An experimental study was done in an unblinded, randomized manner on those treated with and without spermine administration. A morphological examination of hematoxylin–eosin-stained villi was performed under a light microscope with a focus on villi height. Data were subjected to analysis. Results: The median of the spermine-treated group was found to be higher at 24, 26, and 28 days than the non-spermine group, but was not significantly different. Conclusion: Oral spermine supplementation during gestation might improve intestinal villi height in immature rabbit intestines. © Copyright © 2021 Tamba and Moenadjat. |
gestation; immature intestines; rabbit; spermine; villi height |
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Frontiers Media S.A. |
2296875X |
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Article |
Q2 |
483 |
10376 |
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