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No records
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801 |
Siagian S.N., Haas N.A., Prakoso R. |
57214134720;7103216848;57192893243; |
Transcatheter pulmonary balloon valvuloplasty of severe valvar pulmonary stenosis and atrial septal defect in patient with severe cyanosis and very low ventricle ejection fractions: a bailout procedure |
2021 |
Cardiology in the Young |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106665812&doi=10.1017%2fS1047951121001967&partnerID=40&md5=92e3509fdca8f306fe3ccb03a7fd028a |
Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department Pediatric Cardiology and Pediatric Intensive Care, Ludwig Maximilians University, University Hospital, Muenchen, Germany |
Siagian, S.N., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Haas, N.A., Department Pediatric Cardiology and Pediatric Intensive Care, Ludwig Maximilians University, University Hospital, Muenchen, Germany; Prakoso, R., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Most cases of severe or critical pulmonary stenosis are detected early and interventional management is routine within the first days of life. We present a case of a thirteen-year-old boy diagnosed with pulmonary stenosis and atrial septal defect with low ventricle ejection fraction. The patient underwent staged pulmonary balloon valvuloplasty and interventional atrial septal defect closure with good results. © 2021 The Author(s),. Published by Cambridge University Press. |
atrial septal defect; bailout; cyanosis; low ejection fraction; pulmonary balloon valvuloplasty; Pulmonary stenosis |
adolescent; case report; complication; cyanosis; heart septum defect; human; male; pulmonary valve stenosis; transluminal valvuloplasty; Adolescent; Balloon Valvuloplasty; Cyanosis; Heart Septal Defects, Atrial; Humans; Male; Pulmonary Valve Stenosis |
Cambridge University Press |
10479511 |
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34016212 |
Article |
Q3 |
386 |
12454 |
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802 |
Lilihata G., Saputra C., Yaniarti D., Soerarso R. |
57223977510;57223988357;57223991240;57192913673; |
Hyperthyroidism in severe mitral regurgitation post mechanical mitral valve replacement: The effect on warfarin anticoagulation |
2021 |
Cardiovascular Endocrinology and Metabolism |
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146 |
148 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106612745&doi=10.1097%2fXCE.0000000000000233&partnerID=40&md5=01f9076c604667b3b97acb9eb9581c09 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Division of Clinical Cardiology, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia |
Lilihata, G., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Saputra, C., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Yaniarti, D., Division of Clinical Cardiology, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; Soerarso, R., Division of Clinical Cardiology, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia |
A 24-year-old male patient came to the emergency room with melena, gum bleeding and nosebleeds. This patient has a history of mechanical prosthetic mitral valve replacement for severe mitral regurgitation (MR) and consumed warfarin irregularly, but did not come back for regular check-up. Investigations showed greatly increased thyroid function and international normalised ratio (INR) was 15.8. Patients were diagnosed with thyroid storm and bleeding due to prolongation of INR. His hyperthyroid state might have caused increased rate of degradation of vitamin K-dependent clotting factor thereby increased sensitivity to warfarin. Concomitant acute decompensated heart failure, thrombocytopenia and hypoalbuminemia also contributed to his risk of bleeding. Treatment included anti-thyroid therapy as well as warfarin reversal therapy by stopping warfarin, low-dose intravenous vitamin K due to his mechanical prosthetic valve and fresh frozen plasma. In conclusion, hyperthyroidism could increase the response to warfarin so close monitoring is needed to balance the risk of bleeding and thromboembolism. © 2021 Lippincott Williams and Wilkins. All rights reserved. |
anticoagulation; bleeding; hyperthyroidism; mechanical valve; prosthetic valve; warfarin |
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Lippincott Williams and Wilkins |
25740954 |
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Article |
Q3 |
498 |
10107 |
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803 |
Nova R., Nurmaini S., Partan R.U., Putra S.T. |
57210234221;26639610000;57190664693;6603587929; |
Automated image segmentation for cardiac septal defects based on contour region with convolutional neural networks: A preliminary study |
2021 |
Informatics in Medicine Unlocked |
24 |
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100601 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106348104&doi=10.1016%2fj.imu.2021.100601&partnerID=40&md5=37e5f3bcab0ef015f7441efa32757710 |
Department of Child Health, Division of Pediatric Cardiology, Dr. Moh Hoesin Hospital, Faculty of Medicine, Universitas Sriwijaya, Palembang, 30126, Indonesia; Intelligent System Research Group, Universitas Sriwijaya, Palembang, 30139, Indonesia; Department of Medicine, Dr. MohHoesin Hospital, Faculty of Medicine, Universitas Sriwijaya, Palembang, 30126, Indonesia; Department of Child Health, Division of Pediatric Cardiology, Dr. CiptoMangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Nova, R., Department of Child Health, Division of Pediatric Cardiology, Dr. Moh Hoesin Hospital, Faculty of Medicine, Universitas Sriwijaya, Palembang, 30126, Indonesia; Nurmaini, S., Intelligent System Research Group, Universitas Sriwijaya, Palembang, 30139, Indonesia; Partan, R.U., Department of Medicine, Dr. MohHoesin Hospital, Faculty of Medicine, Universitas Sriwijaya, Palembang, 30126, Indonesia; Putra, S.T., Department of Child Health, Division of Pediatric Cardiology, Dr. CiptoMangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Echocardiogram examination is important for diagnosing cardiac septal defects. With the development of AI-based technology, an echocardiogram examination previously performed manually by cardiologists can be done automatically. Automatic segmentation of cardiac septal defects can help a physician to make an initial diagnosis before referring a pediatric cardiologist for further treatment. In previous studies, automatic object segmentation using convolutional neural networks (CNNs) was one of the DL applications that have been developed for cardiac abnormalities. In this study, we propose a CNN-based U-Net architecture to automatically segment the cardiac chamber to detect abnormalities (holes) in the heart septum. In this study, echocardiogram examinations were performed on atrial septal defects (ASDs), ventricular septal defects (VSDs), atrioventricular septal defects (AVSDs), and normal hearts with patients undergoing echocardiogram examination at Moh Hoesin Hospital in Palembang. The results show that even for the relatively small number of datasets, the proposed technique can produce superior performance in the detection of the cardiac septal defects. Using the proposed segmentation model for four classes produces a pixel accuracy of 99.15%, mean intersection over union (IoU) of 94.69%, mean accuracy of 97.73%, sensitivity of 96.02%, and F1 score of 94.88%, respectively. The plots of the loss and accuracy curve show that all the errors were small, with accuracy rates reaching 99.05%, 98.62%, 99.39%, and 98.97% for ASD, VSD, AVSD, and normal heart, respectively. The comparison accuracy of contour prediction for U-Net was 99.01%, while V-Net was 93.70%. This shows that the U-Net has better accuracy than the V-Net model architecture. It can be proven that the architecture of CNNs has been successful in segmenting the cardiac chamber to detect defects in the heart septum and support the work of cardiologists. © 2021 The Authors |
Cardiac septal defect; CNNs; Contour segmentation; Deep learning |
adult; Article; atrioventricular septal defect; child; clinical article; clinical examination; computer assisted diagnosis; controlled study; convolutional neural network; deconvolution; deep learning; diagnostic accuracy; diagnostic test accuracy study; heart atrium septum defect; heart ventricle septum defect; human; image processing; image segmentation; pediatric patient; two dimensional echocardiography |
Elsevier Ltd |
23529148 |
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Article |
Q3 |
440 |
11223 |
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804 |
Wicaksana P., Kurniati N., Pardede S. |
57193446457;36473260300;57210394278; |
Dyslipidemia among HIV-positive children receiving antiretroviral therapy in Indonesia |
2021 |
HIV and AIDS Review |
20 |
1 |
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46 |
51 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106294127&doi=10.5114%2fhivar.2021.105086&partnerID=40&md5=1f2028e2d19b8667b0fe6419e86d0dfd |
Department of Child Health, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Wicaksana, P., Department of Child Health, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Kurniati, N., Department of Child Health, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Pardede, S., Department of Child Health, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Introduction: Antiretroviral (ARV) therapy has changed the status of human immunodeficiency virus (HIV) infection from a high-mortality disease into a chronic one. One of the consequences of long-term use of ARV medications is dyslipidemia, which may progress to cardiovascular disease in the future. The aim of the study was to measure the rate of dyslipidemia among HIV-infected children receiving ARV therapy and related risk factors. Material and methods: A cross-sectional study was conducted at pediatric outpatient clinic, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, from January to July 2019. Lipid profile was examined on 96 eligible subjects and data regarding nutritional status, clinical stage at diagnosis, latest immunosuppression status, latest viral load (VL) value, and latest ARV combination used were obtained from medical records. Bivariate and multivariate analysis were performed to find the association between dependent and independent variables using SPSS version 22. Results: Of 96 subjects included, 52 (54.2%) subjects experienced dyslipidemia. The prevalence of dyslipidemia among those with second-line (containing protease inhibitors) and first-line (containing non-nucleoside reverse transcriptase inhibitors) ARV therapy were 80% and 39%, respectively. The use of second-line ARV therapy was associated with 6.3 times (p < 0.01; 95% CI: 2.4-17.1) increased risk of dyslipidemia compared to first-line ARV therapy. Conclusions: Prevalence of dyslipidemia among HIV-positive children on ARV was high with second-line ARV therapy being a risk factor. © 2021 Termedia Publishing House Ltd.. All rights reserved. |
Children; Dyslipidemia; HAART; HIV; Protease inhibitors |
abacavir; antiretrovirus agent; cholesterol; efavirenz; emtricitabine; high density lipoprotein; lamivudine; lopinavir plus ritonavir; low density lipoprotein; nevirapine; tenofovir; triacylglycerol; zidovudine; adolescent; Article; child; controlled study; cross-sectional study; dyslipidemia; female; highly active antiretroviral therapy; human; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; hypertriglyceridemia; immune deficiency; Indonesia; lipid fingerprinting; major clinical study; male; nutritional status; pediatric hospital; preschool child; prevalence; school child; virus load |
Termedia Publishing House Ltd. |
17301270 |
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Article |
Q4 |
156 |
22602 |
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805 |
Wahid M.H., Findyartini A., Soemantri D., Mustika R., Felaza E., Steinert Y., Samarasekera D.D., Greviana N., Hidayah R.N., Khoiriyah U., Soeselo D.A. |
57192887722;56543777300;36640659100;57220273147;57217487889;7003537985;6506358769;57197709749;57219977261;56803884800;57199998747; |
Professional identity formation of medical teachers in a non-Western setting |
2021 |
Medical Teacher |
43 |
8 |
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868 |
873 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106243417&doi=10.1080%2f0142159X.2021.1922657&partnerID=40&md5=fbc77286f37d3aa77b3991698ebc01ec |
Department of Medical Education and Medical Education Center Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Institute of Health Sciences Education, Faculty of Medicine and Health Sciences, McGill University, Montreal, Canada; Center for Medical Education (CenMED), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Centre for Development of Teaching and Learning, National University of Singapore, Singapore, Singapore; Department of Medical Education and Bioethics, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Faculty of Medicine, Medical Education Unit, Universitas Islam Indonesia, Yogyakarta, Indonesia; Medical Education Unit, School of Medicine and Health Sciences, Universitas Katolik Atma Jaya, Jakarta, Indonesia |
Wahid, M.H., Department of Medical Education and Medical Education Center Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Findyartini, A., Department of Medical Education and Medical Education Center Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soemantri, D., Department of Medical Education and Medical Education Center Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mustika, R., Department of Medical Education and Medical Education Center Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Felaza, E., Department of Medical Education and Medical Education Center Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Steinert, Y., Institute of Health Sciences Education, Faculty of Medicine and Health Sciences, McGill University, Montreal, Canada; Samarasekera, D.D., Center for Medical Education (CenMED), Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, Centre for Development of Teaching and Learning, National University of Singapore, Singapore, Singapore; Greviana, N., Department of Medical Education and Medical Education Center Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hidayah, R.N., Department of Medical Education and Bioethics, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Khoiriyah, U., Faculty of Medicine, Medical Education Unit, Universitas Islam Indonesia, Yogyakarta, Indonesia; Soeselo, D.A., Medical Education Unit, School of Medicine and Health Sciences, Universitas Katolik Atma Jaya, Jakarta, Indonesia |
Introduction: Understanding and supporting professional identity formation (PIF) among medical teachers has become increasingly important in faculty development programs. In this study, we explored medical teachers’ PIF in Indonesia. Methods: We conducted a qualitative descriptive study using focus group discussions (FGDs) at four medical schools in Indonesia. Basic science and clinical teachers from four different schools were selected to participate. Data were transcribed, coded, and analysed to develop themes and subthemes. Results: Seventeen FGDs were completed, involving 60 basic science and 59 clinical teachers. Four major themes regarding the formation of medical teachers’ professional identity emerged: an internal dialogue between intrinsic values and external influences, empowerment through early socialization, experiential workplace learning, and envisioning the future. The PIF process was similar for basic science and clinical teachers. Conclusion: Our findings suggested that PIF among medical teachers in a non-Western setting is a continuous and dynamic process that is shaped by key socialization factors (e.g. role models, workplace learning, peer support), with significant influences from religious beliefs, family values, and societal recognition. Faculty development programs should consider the dynamic and continuous nature of PIF among medical teachers and encourage clinicians and basic scientists to explore their values and beliefs, realize their goals, and envision their future. © 2021 Informa UK Limited, trading as Taylor & Francis Group. |
professionalism; roles of teacher; Staff development |
article; empowerment; genetic transcription; human; Indonesia; learning; medical school; peer group; personnel management; professionalism; religion; socialization; teacher; workplace; medical school; qualitative research; social behavior; university; Faculty; Humans; Learning; Qualitative Research; Schools, Medical; Social Identification |
Taylor and Francis Ltd. |
0142159X |
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33989110 |
Article |
Q1 |
1355 |
2689 |
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806 |
Adriztina I., Munir D., Sandra F., Ichwan M., Bashiruddin J., Putra I.B., Farhat, Sembiring R.J., Sartika C.R., Chouw A., Pratiwi E.D. |
56928394300;57039203600;56016164200;26040779000;56469338300;57194636376;57194721197;57038845000;57205297509;56431084200;57223858156; |
Differentiation capacity of dental pulp stem cell into inner ear hair cell using an in vitro assay: a preliminary step toward treating sensorineural hearing loss |
2021 |
European Archives of Oto-Rhino-Laryngology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106239040&doi=10.1007%2fs00405-021-06864-9&partnerID=40&md5=5a4ff939b0fff7361593d6d043015bd8 |
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansyur No 5, Medan, Sumatera Utara 20155, Indonesia; Division of Oral Biology, Departement of Biochemistry and Molecular Biology, Faculty of Dentistry, Trisakti University, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Dermatovenerology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Prodia Stemcell Indonesia, Jl. Kramat VII No.11, Jakarta, Indonesia |
Adriztina, I., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansyur No 5, Medan, Sumatera Utara 20155, Indonesia; Munir, D., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansyur No 5, Medan, Sumatera Utara 20155, Indonesia; Sandra, F., Division of Oral Biology, Departement of Biochemistry and Molecular Biology, Faculty of Dentistry, Trisakti University, Jakarta, Indonesia; Ichwan, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Bashiruddin, J., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Putra, I.B., Department of Dermatovenerology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Farhat, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansyur No 5, Medan, Sumatera Utara 20155, Indonesia; Sembiring, R.J., Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Sartika, C.R., Prodia Stemcell Indonesia, Jl. Kramat VII No.11, Jakarta, Indonesia; Chouw, A., Prodia Stemcell Indonesia, Jl. Kramat VII No.11, Jakarta, Indonesia; Pratiwi, E.D., Prodia Stemcell Indonesia, Jl. Kramat VII No.11, Jakarta, Indonesia |
Purpose: Sensorineural hearing loss (SNHL) is commonly caused by the death or dysfunction of cochlear cell types as a result of their lack of regenerative capacity. However, regenerative medicine, such as stem cell therapy, has become a promising tool to cure many diseases, including hearing loss. In this study, we determined whether DPSCs could differentiate into cochlear hair cell in vitro. Methods: DPSCs derived from human third molar dental pulp were induced into NSCs using a medium containing basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) for 7 days, and then into cochlear hair cell using a medium containing EGF and IGF-1 for the next 14 days. We used the neuroepithelial protein marker nestin and cochlear hair cell marker myosin VIIa as the markers for cells differentiation. Cells expressing the positive markers under the microscope were confirmed to have differentiated into cochlear hair cell. Results: DPSCs were successfully induced to differentiate into NSCs, with mean 24% nestin-positive cells. We found that DPSC-derived NSCs have a great capacity in differentiating into inner ear hair cell-like cells with an average of 81% cells presenting myosin VIIa. Thus, DPSCs have high potential to serve as a good resource for SNHL treatment. Conclusion: We found the high potential of DPSCs to differentiate into NSC. The ability of DPSCs in differentiating into neural lineage cell made them a good candidate for regenerative therapy in neural diseases, such as SNHL © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
Cochlear hair cell; Dental pulp stem cells; Sensorineural hearing loss |
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Springer Science and Business Media Deutschland GmbH |
09374477 |
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34008035 |
Article |
Q1 |
849 |
5560 |
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807 |
Jusman S.W.A., Azzizah I.N., Sadikin M., Hardiany N.S. |
36518792100;57223677370;57205093115;57192910605; |
Is the mitochondrial function of keloid fibroblasts affected by cytoglobin? |
2021 |
Malaysian Journal of Medical Sciences |
28 |
2 |
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39 |
47 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106010069&doi=10.21315%2fmjms2021.28.2.4&partnerID=40&md5=8c4df0a7d2cdcd87611b189bf2440f21 |
Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Indonesia; Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Jusman, S.W.A., Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Azzizah, I.N., Faculty of Medicine Universitas Indonesia, Indonesia; Sadikin, M., Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hardiany, N.S., Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: A keloid is a benign skin tumour characterised by excessive proliferation of fibroblasts, a process that requires a sufficient amount of energy. The energy needs are associated with adequate oxygen (O2) flow and well-functioning mitochondria. It is known that cytoglobin (CYGB) has a function in O2 distribution. The aim of the present study was to explore whether the inhibition of CYGB expression caused impaired mitochondrial function of keloid fibroblasts. Methods: An in vitro study was conducted on a keloid fibroblast derived from our previous study. The study was carried out in the laboratory of the Biochemistry & Molecular Biology Department, Faculty of Medicine, Universitas Indonesia (FMUI), from July to December 2018. CYGB expression was inhibited by small interfering ribonucleic acid (siRNA) and CYGB. Analysis of mitochondrial function was observed through peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), a mitochondrial biogenesis marker and the activity of the succinate dehydrogenase (SDH) enzyme in mitochondria. Results: The CYGB gene and protein were downregulated after treatment with CYGB siRNA. Inhibition of CYGB expression with siRNA also tended to decrease the levels of PGC-1α messenger ribonucleic acid (mRNA) and protein, as well as SDH enzyme activity. Conclusion: Inhibition of CYGB expression with siRNA tended to decrease mitochondrial biogenesis and function. This may be useful for understanding the excessive proliferation of fibroblasts in keloids and for development of treatment for keloids. © Penerbit Universiti Sains Malaysia, 2021. |
CYGB siRNA; Keloid fibroblasts; PGC-1α; SDH enzyme activity |
cytoglobin; oxygen; peroxisome proliferator activated receptor gamma coactivator 1alpha; small interfering RNA; succinate dehydrogenase; Article; cell function; cell proliferation; colorimetry; controlled study; down regulation; enzyme activity; enzyme linked immunosorbent assay; fibroblast; gene expression; genetic transfection; human; human cell; in vitro study; keloid; mitochondrial biogenesis; mitochondrial genetics; mRNA expression level; protein expression; protein isolation; real time polymerase chain reaction; reverse transcription; RNA isolation |
Penerbit Universiti Sains Malaysia |
1394195X |
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Article |
Q3 |
394 |
12287 |
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808 |
Ambarsari C.G., Hidayati E.L., Tridjaja B., Mochtar C.A., Wulandari H.F., Harahap A.S., Grace A. |
57211850895;57200542624;6504507193;6506558321;57223434925;57218511857;57217085273; |
Silent Hypertensive Crisis in an Adolescent: First Case Report of Pediatric Pheochromocytoma from Indonesia |
2021 |
Global Pediatric Health |
8 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105884851&doi=10.1177%2f2333794X211015484&partnerID=40&md5=51b6ae929a36713aa5a073baeb034198 |
Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Ambarsari, C.G., Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hidayati, E.L., Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Tridjaja, B., Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Mochtar, C.A., Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wulandari, H.F., Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harahap, A.S., Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Grace, A., Faculty of Medicine, Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Secondary hypertension in children, to the rare extent, can be caused by endocrine factors such as pheochromocytoma, an adrenal tumor that secretes catecholamine. Only a few cases have been reported in the past 3 decades. To the best of our knowledge, this is the first case report of pediatric pheochromocytoma from Indonesia. We reviewed a case of a 16-year-old Indonesian boy with history of silent hypertensive crisis who was referred from a remote area in an island to the pediatric nephrology clinic at Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Despite medications, his symptoms persisted for 14 months. At the pediatric nephrology clinic, pheochromocytoma was suspected due to symptoms of catecholamine secretion presented, which was palpitation, diaphoresis, and weight loss. However, as the urine catecholamine test was unavailable in Indonesia, the urine sample was sent to a laboratory outside the country. The elevated level of urine metanephrine, focal pathological uptake in the right adrenal mass seen on 131I-MIBG, and histopathology examination confirmed the suspicion of pheochromocytoma. Following the tumor resection, he has been living with normal blood pressure without antihypertensive medications. This case highlights that pheochromocytoma should always be included in the differential diagnoses of any atypical presentation of hypertension. In limited resources setting, high clinical awareness of pheochromocytoma is required to facilitate prompt referral. Suspicion of pheochromocytoma should be followed by measurement of urine metanephrine levels. Early diagnosis of pheochromocytoma would fasten the optimal cure, alleviate the symptoms of catecholamine release, and reverse hypertension. © The Author(s) 2021. |
adrenal glands; blood pressure; epinephrine; metanephrine; MIBG; norepinephrine |
bisoprolol; captopril; catecholamine; creatinine; furosemide; liothyronine; nebivolol; nifedipine; telmisartan; terazosin; vitamin D; adolescent; adrenalectomy; Article; case report; clinical article; diaphoresis; Doppler flowmetry; free thyroxine index; heart palpitation; human; hypertension; hypertensive crisis; Indonesian; kidney artery stenosis; male; nuclear magnetic resonance imaging; pheochromocytoma; scintigraphy; tachycardia |
SAGE Publications Inc. |
2333794X |
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Article |
Q2 |
354 |
13264 |
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809 |
Prabowo Y., Setiawan I., Kamal A.F., Kodrat E., Labib Zufar M.L. |
56682042400;57223371887;56648996700;57191430080;57223359525; |
Correlation between Prognostic Factors and the Histopathological Response to Neoadjuvant Chemotherapy in Osteosarcoma: A Retrospective Study |
2021 |
International Journal of Surgical Oncology |
2021 |
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8843325 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105720428&doi=10.1155%2f2021%2f8843325&partnerID=40&md5=f2aca94957d4723aa31b40e604603c25 |
Department of Orthopedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology Cipto, Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Prabowo, Y., Department of Orthopedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Setiawan, I., Department of Orthopedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kamal, A.F., Department of Orthopedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kodrat, E., Department of Anatomical Pathology Cipto, Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Labib Zufar, M.L., Department of Orthopedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background.Multimodality treatment, incorporating neoadjuvant chemotherapy and adjuvant chemotherapy, is the standard management plan for osteosarcoma that increases the overall survival (OS) rate. However, data regarding prognostic factors affecting the histopathological response following neoadjuvant chemotherapy is limited. Patients and Methods. We retrospectively reviewed patients diagnosed with osteosarcoma in our center between 2008 and 2018. We classified patient characteristics according to gender, age, tumor size, site and stage at diagnosis, site of metastasis, type of surgery, necrosis rate based on the Huvos grading system, and the number of neoadjuvant chemotherapy cycles. We divided response to neoadjuvant chemotherapy into poor responder for patients with Huvos grades 1 and 2 and good responder for patients with Huvos grades 3 and 4. We also documented patients' survival and follow-up information. Results. We reviewed 64 patients within 5-65 years of age, dominated by men (62.5%). The distal femur (53.1%) was the most common site of osteosarcoma. Fifteen (23.4%) patients had a good response while 49 (76.6%) patients were poor responders to neoadjuvant chemotherapy based on the Huvos grading system. Based on multivariate analysis, gender (p = 0.012), age (p = 0.029), symptom duration (p = 0.004), and tumor enlargement after neoadjuvant chemotherapy (p < 0.001) were significantly associated with histopathological response. A scoring system was proposed integrating these significant variables (age > 20 years = 1 point, female gender = 1 point, symptom duration > 12 weeks = 1 point, and increased tumor size after neoadjuvant chemotherapy = 2 points). This scoring system divides patients into two groups with a total score of more than two predicting a poor responder to neoadjuvant chemotherapy. Conclusions. Age, gender, symptoms duration, and tumor size after neoadjuvant chemotherapy are the prognostic features that affect the histopathological response to neoadjuvant chemotherapy in patients with osteosarcoma. © 2021 Yogi Prabowo et al. |
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antineoplastic agent; adjuvant chemotherapy; adolescent; adult; aged; bone tumor; child; female; follow up; human; male; middle aged; mortality; neoadjuvant therapy; osteosarcoma; pathology; preschool child; prognosis; retrospective study; survival analysis; young adult; Adolescent; Adult; Aged; Antineoplastic Agents; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Prognosis; Retrospective Studies; Survival Analysis; Young Adult |
Hindawi Limited |
20901402 |
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33996154 |
Article |
Q3 |
432 |
11391 |
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810 |
Suwantika A.A., Zakiyah N., Abdulah R., Sitohang V., Tandy G., Anartati A., Hidayatullah T., Herliana P., Hadinegoro S.R. |
55757798100;56073623400;9244834900;57201802658;57208105012;35602938500;35117792500;57203394399;57226218772; |
Cost-Effectiveness and Budget Impact Analyses of Pneumococcal Vaccination in Indonesia |
2021 |
Journal of Environmental and Public Health |
2021 |
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7494965 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105700019&doi=10.1155%2f2021%2f7494965&partnerID=40&md5=bbd858611fb710b7cc2cabf814a8c66b |
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, 45363, Indonesia; Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, 45363, Indonesia; Directorate of Health Surveillance and Quarantine, Directorate General of Disease Prevention and Control, Ministry of Health, Jakarta, 12750, Indonesia; Clinton Health Access Initiative, Jakarta, 10450, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia |
Suwantika, A.A., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, 45363, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, 45363, Indonesia; Zakiyah, N., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, 45363, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, 45363, Indonesia; Abdulah, R., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, 45363, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, 45363, Indonesia; Sitohang, V., Directorate of Health Surveillance and Quarantine, Directorate General of Disease Prevention and Control, Ministry of Health, Jakarta, 12750, Indonesia; Tandy, G., Directorate of Health Surveillance and Quarantine, Directorate General of Disease Prevention and Control, Ministry of Health, Jakarta, 12750, Indonesia; Anartati, A., Clinton Health Access Initiative, Jakarta, 10450, Indonesia; Hidayatullah, T., Clinton Health Access Initiative, Jakarta, 10450, Indonesia; Herliana, P., Clinton Health Access Initiative, Jakarta, 10450, Indonesia; Hadinegoro, S.R., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia |
As a country with the high number of deaths due to pneumococcal disease, Indonesia has not yet included pneumococcal vaccination into the routine program. This study aimed to analyse the cost-effectiveness and the budget impact of pneumococcal vaccination in Indonesia by developing an age-structured cohort model. In a comparison with no vaccination, the use of two vaccines (PCV10 and PCV13) within two pricing scenarios (UNICEF and government contract price) was taken into account. To estimate the cost-effectiveness value, a 5-year time horizon was applied by extrapolating the outcome of the individual in the modelled cohort until 5 years of age with a 1-month analytical cycle. To estimate the affordability value, a 6-year period (2019-2024) was applied by considering the government's strategic plan on pneumococcal vaccination. In a comparison with no vaccination, the results showed that vaccination would reduce pneumococcal disease by 1,702,548 and 2,268,411 cases when using PCV10 and PCV13, respectively. Vaccination could potentially reduce the highest treatment cost from the payer perspective at $53.6 million and $71.4 million for PCV10 and PCV13, respectively. Applying the UNICEF price, the incremental cost-effectiveness ratio (ICER) from the healthcare perspective would be $218 and $162 per QALY-gained for PCV10 and PCV13, respectively. Applying the government contract price, the ICER would be $987 and $747 per QALY-gained for PCV10 and PCV13, respectively. The result confirmed that PCV13 was more cost-effective than PCV10 with both prices. In particular, introduction cost per child was estimated to be $0.91 and vaccination cost of PCV13 per child (3 doses) was estimated to be $16.61 and $59.54 with UNICEF and government contract prices, respectively. Implementation of nationwide vaccination would require approximately $73.3-$75.0 million (13-14% of routine immunization budget) and $257.4-$263.5 million (45-50% of routine immunization budget) with UNICEF and government contract prices, respectively. Sensitivity analysis showed that vaccine efficacy, mortality rate, and vaccine price were the most influential parameters affecting the ICER. In conclusion, pneumococcal vaccination would be a highly cost-effective intervention to be implemented in Indonesia. Yet, applying PCV13 with UNICEF price would give the best cost-effectiveness and affordability values on the routine immunization budget. © 2021 Auliya A. Suwantika et al. |
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pcv 10; Pneumococcus vaccine; Pneumococcus vaccine; Article; budget; budget impact analysis; case control study; case fatality rate; child; cohort analysis; comparative effectiveness; contract; controlled study; cost effectiveness analysis; drug cost; drug efficacy; economic evaluation; government; health care cost; human; incidence; incremental cost effectiveness ratio; Indonesia; infection prevention; mortality rate; outcome assessment; pneumococcal infection; price; quality adjusted life year; sensitivity analysis; strategic planning; Streptococcus pneumonia; United Nations Children's Fund; vaccination; cost benefit analysis; economics; Budgets; Child; Cost-Benefit Analysis; Humans; Indonesia; Pneumococcal Vaccines; Vaccination |
Hindawi Limited |
16879805 |
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33995536 |
Article |
Q2 |
869 |
5372 |
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