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Permata T.B.M., Sato H., Gu W., Kakoti S., Uchihara Y., Yoshimatsu Y., Sato I., Kato R., Yamauchi M., Suzuki K., Oike T., Tsushima Y., Gondhowiardjo S., Ohno T., Yasuhara T., Shibata A. |
57197808751;55697961900;57211574572;57197814645;57221723636;57284438600;57285097100;57204087445;8307897300;57376271900;36453136000;57284002500;6508327402;35395665700;56562637100;8323572900; |
High linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells |
2021 |
Journal of Radiation Research |
62 |
5 |
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773 |
781 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115918333&doi=10.1093%2fjrr%2frrab050&partnerID=40&md5=a1550b83230aa8ab90277d2716e9a556 |
Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan; Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Gunma University Heavy IonMedical Center, Gunma, Maebashi, 371-8511, Japan; Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan; Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School OfMedicine, Gunma, Maebashi, 371-8511, Japan; Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School OfMedicine, The University OfTokyo, Bunkyo-ku, Tokyo, 113-8655, Japan; Department of Radiation Biology and Protection, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan; Department of Radiation Medical Science, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan |
Permata, T.B.M., Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan, Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Sato, H., Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan, Gunma University Heavy IonMedical Center, Gunma, Maebashi, 371-8511, Japan; Gu, W., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan, Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School OfMedicine, Gunma, Maebashi, 371-8511, Japan; Kakoti, S., Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan, Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan; Uchihara, Y., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan; Yoshimatsu, Y., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan, Department of Diagnostic Radiology and Nuclear Medicine, Gunma University Graduate School OfMedicine, Gunma, Maebashi, 371-8511, Japan; Sato, I., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan; Kato, R., Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School OfMedicine, The University OfTokyo, Bunkyo-ku, Tokyo, 113-8655, Japan; Yamauchi, M., Department of Radiation Biology and Protection, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan; Suzuki, K., Department of Radiation Medical Science, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan; Oike, T., Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan; Tsushima, Y., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan; Gondhowiardjo, S., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Ohno, T., Department of Radiation Oncology, Gunma University, Gunma, Maebashi, 371-8511, Japan, Gunma University Heavy IonMedical Center, Gunma, Maebashi, 371-8511, Japan; Yasuhara, T., Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School OfMedicine, The University OfTokyo, Bunkyo-ku, Tokyo, 113-8655, Japan; Shibata, A., Gunma University Initiative for Advanced Research (GIAR), Gunma University, Gunma, Maebashi, 371-8511, Japan |
Programmed death ligand 1 (PD-L1) expression on the surface of cancer cells affects the efficacy of anti-PD-1/PD-L1 immune checkpoint therapy. However, the mechanism underlying PD-L1 expression in cancer cells is not fully understood, particularly after ionizing radiation (IR). Here, we examined the impact of high linear energy transfer (LET) carbon-ion irradiation on the expression of PD-L1 in human osteosarcoma U2OS cells. We found that the upregulation of PD-L1 expression after high LET carbon-ion irradiation was greater than that induced by X-rays at the same physical and relative biological effectiveness (RBE) dose, and that the upregulation of PD-L1 induced by high LET carbon-ion irradiation was predominantly dependent on ataxia telangiectasia and Rad3-related (ATR) kinase activity. Moreover, we showed that the downstream signaling, e.g. STAT1 phosphorylation and IRF1 expression, was upregulated to a greater extent after high LET carbon-ion irradiation than X-rays, and that IRF1 upregulation was also ATR dependent. Finally, to visualize PD-L1 molecules on the cell surface in 3D, we applied immunofluorescence-based super-resolution imaging. The three-dimensional structured illumination microscopy (3D-SIM) analyses revealed substantial increases in the number of presented PD-L1 molecules on the cell surface after high LET carbon-ion irradiation compared with X-ray irradiation. © 2021 The Author(s) 2021. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. |
anti-PD-1/PD-L1 therapy; DNA damage response; high linear energy transfer (LET) carbon-ion therapy; PD-L1 expression |
Carbon; Cell membranes; Cytology; Diseases; Ionizing radiation; Ions; Molecules; Oncology; Radiotherapy; Anti-PD-1/programmed death ligand 1 therapy; Carbon ion therapy; Carbon ions; DNA damage response; High linear energy transfer carbon-ion therapy; High linear energy transfers; Human osteosarcoma; Ions irradiation; Programmed death ligand 1 expression; Up-regulation; Energy transfer; 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide; ATM protein; ATM protein, human; ATR protein, human; CD274 protein, human; interferon regulatory factor 1; IRF1 protein, human; messenger RNA; morpholine derivative; programmed death 1 ligand 1; pyrazine derivative; pyrone derivative; RNA; STAT1 protein; STAT1 protein, human; sulfone; tumor p |
Oxford University Press |
04493060 |
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34196706 |
Article |
Q2 |
643 |
7838 |
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202 |
Rusdi N.K., Purwaningsih E.H., Hestiantoro A., Elya B., Kusmardi K. |
57211475250;57186723500;8743255100;14014224500;56966625300; |
In vivo antimammary tumor effects of soybean extract with targeted lunasin (ET-Lun) |
2021 |
Pharmacognosy Journal |
13 |
5 |
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1269 |
1276 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115297490&doi=10.5530%2fpj.2021.13.160&partnerID=40&md5=d96a1538654afeda0377ba6b0d8a5e38 |
Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, Indonesia; Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department Obstetrics and Gynaecology, School of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia; Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas INDONESIA, Indonesia |
Rusdi, N.K., Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, Indonesia; Purwaningsih, E.H., Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia; Hestiantoro, A., Department Obstetrics and Gynaecology, School of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Elya, B., Department of Phytochemistry, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Kusmardi, K., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia, Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas INDONESIA, Indonesia |
Background/Objective: Lunasin is a peptide, consist of 44 amino acids which have anti-cancer, antioxidant, and anti-inflammatory activity. The price of commercial Lunasin was very expensive due to the high cost of lunasin synthesis and the lack of methods to obtain the pure lunasin weight from plant sources, involving time-consuming analytical instruments. To overcome these problems, the soybean extract with targeted Lunasin (ET-Lun) was made. The aim of this study was to investigate anti-cancer properties of ET-Lun in breast cancer models in vivo. Methods: Effect of ET-Lun was evaluated in 7,12-Dimetilbenz[a]antrasen (DMBA) induced breast cancer rat model. Tumor Mass, volume, and number were measured. The expression of HER2 and EGFR from each treatment group in DMBA-induced rat was evaluated using immunohistochemistry. Results: The results shown that ET-Lun could reduced tumor volume (p=0,021). ET-Lun decreased EGFR expression compared to negative control DMBA (p=0,012). Conclusions: These results indicated that the ET-Lun has anti-breast cancer activity in vivo. © 2021 Phcogj.Com. |
Breast cancer; EGFR; HER2; In-vivo; Soybean |
dimethylbenz[a]anthracene; epidermal growth factor receptor; epidermal growth factor receptor 2; lunasin; peptide; soybean extract; tamoxifen; unclassified drug; aged; animal experiment; animal model; animal tissue; antineoplastic activity; Article; breast cancer; controlled study; female; immunohistochemistry; in vivo study; nonhuman; protein expression; rat; soybean; tumor number; tumor volume |
EManuscript Technologies |
09753575 |
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Article |
Q3 |
268 |
15961 |
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206 |
Findyartini A., Greviana N., Hanum C., Husin J.M., Sudarsono N.C., Krisnamurti D.G.B., Rahadiani P. |
56543777300;57197709749;57257072300;57221607411;57201862518;55934951600;55524183700; |
Supporting newly graduated medical doctors in managing COVID-19: An evaluation of a Massive Open Online Course in a limitedresource setting |
2021 |
PLoS ONE |
16 |
9 September |
e0257039 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114841740&doi=10.1371%2fjournal.pone.0257039&partnerID=40&md5=d823d8aaf9a69d130347230f477800d5 |
Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sports and Exercise Study, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Center for E-learning, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Findyartini, A., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Greviana, N., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hanum, C., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Husin, J.M., Medical Education Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sudarsono, N.C., Sports and Exercise Study, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Krisnamurti, D.G.B., Center for E-learning, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Department of Pharmacy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rahadiani, P., Center for E-learning, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction Newly graduated medical doctors in their internships are positioned to strengthen the front line in combating COVID-19. We developed a Massive Open Online Course (MOOC) to equip them with adequate knowledge for COVID-19 management. This paper aims to analyze the MOOC and evaluate participant satisfaction and increase in knowledge after completing the course. Methods An observational study was conducted. Quantitative data were obtained from questionnaires and pre-and post-Tests. Responses to open-ended questions of the questionnaires were collected. Analysis using the Quality Reference Framework was also completed. Results The MOOC consisted of fundamental knowledge of COVID-19 (Part A) and further enrichment (Part B), and the content was written in the Indonesian language. A total of 3,424 and 2,462 participants completed the course in August and November 2020, respectively. Most participants agreed that the platform was easy to navigate, the design was interesting, and the content was aligned with their needs. Pre-and post-Test scores in Part A s subjects increased significantly. Factors contributing to and inhibiting usability and areas for improvement were further highlighted. Discussion The use of a specific quality framework facilitated a comprehensive evaluation of the MOOC s strengths, weaknesses, and areas for future improvements. The participants satisfaction and pre-and post-Test results showed that the current MOOC holds great potential benefit for continuing education for medical interns joining the frontliners during the pandemic. Future implementation should consider increasing the quality of learning resources, scaling up the platform and its technical supports, and enhancing organizational supports. © 2021 Public Library of Science. All rights reserved. |
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education; epidemiology; human; Indonesia; medical education; procedures; program evaluation; questionnaire; COVID-19; Education, Distance; Education, Medical, Graduate; Educational Measurement; Humans; Indonesia; Program Evaluation; Surveys and Questionnaires |
Public Library of Science |
19326203 |
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34506524 |
Article |
Q1 |
990 |
4434 |
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209 |
Lasmono A., Ismail R.I., Kaligis F., Minayati K., Wiguna T. |
57243772800;55996895500;36604651700;57218681686;24367785700; |
Empathy quotient and systemizing quotient in elementary school children with and without attention-deficit/hyperactivity disorder: A comparative study |
2021 |
International Journal of Environmental Research and Public Health |
18 |
17 |
9231 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114150588&doi=10.3390%2fijerph18179231&partnerID=40&md5=2177023e11ec7cb0573abfd7f195ae8f |
Department of Psychiatry, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, 10430, Indonesia; Child and Adolescent Psychiatry Division, Department of Psychiatry, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, 10430, Indonesia |
Lasmono, A., Department of Psychiatry, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, 10430, Indonesia; Ismail, R.I., Child and Adolescent Psychiatry Division, Department of Psychiatry, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, 10430, Indonesia; Kaligis, F., Child and Adolescent Psychiatry Division, Department of Psychiatry, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, 10430, Indonesia; Minayati, K., Child and Adolescent Psychiatry Division, Department of Psychiatry, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, 10430, Indonesia; Wiguna, T., Child and Adolescent Psychiatry Division, Department of Psychiatry, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, 10430, Indonesia |
This study compares the Empathy Quotient (EQ) and Systemizing Quotient (SQ) scores of elementary school children with and without ADHD. The study also examined their brain types and, because sex plays a big role in empathy and systemizing ability, compared the results of the boys and girls. This cross-sectional study involved 122 participants, including 61 parents of children with ADHD and 61 parents of children without ADHD. The EQ, SQ and brain types were obtained using the Empathy and Systemizing Quotient in children (EQ-/SQ-C), validated in the Indonesian language. Data was analyzed using the SPSS program version 20 for Windows, with a p-value < 0.05 for statistical significance. There was a significant difference in EQ between children with and without ADHD, the score being lower in children with ADHD. There was also a significant difference in SQ among girls with and without ADHD, but not in boys. The brain types in both groups were not significantly different. The results indicate that children with ADHD have a lower ability to empathize compared to children without ADHD. Systemizing abilities were significantly lower in girls with ADHD than in girls without. Therefore, an intervention program focusing on improving empathy and systemizing ability needs to be developed in the community. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
ADHD; Children; Empathy quotient; EQ; Indonesia; SQ; Systemizing quotient |
child health; comparative study; health care; public health; adult; Article; attention deficit disorder; behavior assessment; child; comparative study; controlled study; cross-sectional study; elementary student; empathy; empathy quotient; female; human; human relation; ICD-10; Indonesian; Kolmogorov Smirnov test; major clinical study; male; school child; self concept; sex difference; social psychology; systemizing; systemizing quotient; validation study; attention deficit disorder; brain; school; Indonesia; Attention Deficit Disorder with Hyperactivity; Brain; Child; Cross-Sectional Studies; Empathy; Female; Humans; Male; Schools |
MDPI |
16617827 |
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34501828 |
Article |
Q2 |
747 |
6560 |
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212 |
Librianto D., Aprilya D. |
57192894799;57193710642; |
Cantilever method for severe kyphotic deformity correction in spondylitis tuberculosis: A technical note and literature review |
2021 |
Annals of Medicine and Surgery |
69 |
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102764 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113387050&doi=10.1016%2fj.amsu.2021.102764&partnerID=40&md5=65a7cd7e9c389e8ea978726e602d9fe3 |
Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Fatmawati General Hospital, Jakarta, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Librianto, D., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Fatmawati General Hospital, Jakarta, Indonesia; Aprilya, D., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: The kyphotic deformity is more than just a cosmetic disfigurement. It is potentially life-threatening and disturbs the quality of life by causing cardiopulmonary dysfunction, spinal imbalance, and other associated problems. Corrective surgery is challenging but it is needed to bring the spinal balance back thus halting the progressiveness of the deformity. The cantilever technique is a gold standard to correct the sagittal plane deformity. Methods: This is a review article with some case illustrations from Author's experience. Objective: We aim to review the cantilever technique for kyphotic correction in spondylitis tuberculosis patients. Conclusion: The cantilever technique is the standard for sagittal plane deformity correction that can be applied for kyphotic deformity correction in spondylitis tuberculosis cases. Developing the safest techniques and instrumentation is crucial to achieving spinal balance with minimal risk of morbidities. © 2021 |
Cantilever method; Deformity correction; Kyphotic deformity; Spondylitis tuberculosis |
cosmetic; backache; biopsy; bone graft; cardiopulmonary insufficiency; comorbidity; decortication; deformity; follow up; gold standard; graft failure; human; kyphosis; laminectomy; morbidity; nerve injury; nuclear magnetic resonance imaging; osteotomy; pain; quality of life; Review; screw loosening; spinal cord decompression; spinal cord lesion; spine malformation; systematic review; tissue culture; tuberculous spondylitis; vascularization |
Elsevier Ltd |
20490801 |
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Review |
Q3 |
391 |
12334 |
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216 |
Pawankar R., Thong B.Y.-H., Tiongco-Recto M., Wang J.-Y., Abdul Latiff A.H., Thien F., Oh J.-W., Kamchaisatian W., Rengganis I., Udwadia Z.F., Dhar R., Munkhbayarlakh S., Narantsetseg L., Le Pham D., Leung T.F., Zhang L., APAAACI COVID-19 Working Group |
7005904460;6603816215;55359899500;56499349900;55608026700;57204250177;55657464600;6505855073;8449988000;57192641184;7006700626;56800881300;8977752900;57201431490;57225672394;36068675900; |
Asia-Pacific perspectives on the COVID-19 pandemic |
2021 |
Allergy: European Journal of Allergy and Clinical Immunology |
76 |
9 |
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2998 |
2901 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106213191&doi=10.1111%2fall.14894&partnerID=40&md5=a8dda5140c82a54f09e8a12b2804a47c |
Division of Allergy, Department of Pediatrics, Nippon Medical School, Tokyo, Japan; Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore City, Singapore; Division of Allergy and Immunology, Department of Pediatrics, University of the Philippines-Philippine General Hospital, Manila, Philippines; Centre of Allergy and Clinical Immunology Research (ACIR), Department of Paediatrics, National Cheng Kung University Hospital, Tainan, Taiwan; Allergy & Immunology Centre Pantai Hospital, Kuala Lumpur, Malaysia; Department of Paediatrics, Universiti Putra Malaysia Teaching Hospital, Kuala Lumpur, Malaysia; Eastern Health, Monash University, Melbourne, Vic, Australia; Department of Pediatrics, Hanyang University Guri Hospital, Guri, Gyunggi-Do, South Korea; Pediatric Allergy and Immunology Division, Samitivej Children’s Hospital, Bangkok, Thailand; Division of Allergy and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, CiptoMangunkusumo General Hopsital, Jakarta, Indonesia; P.D. Hinduja National Hospital and Medical Research Centre and the Breach Candy Hospital, Mumbai, India; Department of Pulmonology, C K BIRLA Group of Hospitals, CMRIKolkata, India; Department of Pulmonology and Allergology, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia; Department of Biochemistry, School of Biomedicine, MongolianNational University of Medical Sciences, Ulaanbaatar, Mongolia; Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Department of Pediatrics, Chinese University of Hong Kong, Hong Kong; Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China |
Pawankar, R., Division of Allergy, Department of Pediatrics, Nippon Medical School, Tokyo, Japan; Thong, B.Y.-H., Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore City, Singapore; Tiongco-Recto, M., Division of Allergy and Immunology, Department of Pediatrics, University of the Philippines-Philippine General Hospital, Manila, Philippines; Wang, J.-Y., Centre of Allergy and Clinical Immunology Research (ACIR), Department of Paediatrics, National Cheng Kung University Hospital, Tainan, Taiwan; Abdul Latiff, A.H., Allergy & Immunology Centre Pantai Hospital, Kuala Lumpur, Malaysia, Department of Paediatrics, Universiti Putra Malaysia Teaching Hospital, Kuala Lumpur, Malaysia; Thien, F., Eastern Health, Monash University, Melbourne, Vic, Australia; Oh, J.-W., Department of Pediatrics, Hanyang University Guri Hospital, Guri, Gyunggi-Do, South Korea; Kamchaisatian, W., Pediatric Allergy and Immunology Division, Samitivej Children’s Hospital, Bangkok, Thailand; Rengganis, I., Division of Allergy and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, CiptoMangunkusumo General Hopsital, Jakarta, Indonesia; Udwadia, Z.F., P.D. Hinduja National Hospital and Medical Research Centre and the Breach Candy Hospital, Mumbai, India; Dhar, R., Department of Pulmonology, C K BIRLA Group of Hospitals, CMRIKolkata, India; Munkhbayarlakh, S., Department of Pulmonology and Allergology, School of Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia; Narantsetseg, L., Department of Biochemistry, School of Biomedicine, MongolianNational University of Medical Sciences, Ulaanbaatar, Mongolia; Le Pham, D., Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Leung, T.F., Department of Pediatrics, Chinese University of Hong Kong, Hong Kong; Zhang, L., Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China; APAAACI COVID-19 Working Group |
[No abstract available] |
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biological product; chloroquine; convalescent plasma; corticosteroid; hydroxychloroquine; immunosuppressive agent; lopinavir plus ritonavir; remdesivir; tocilizumab; asthma; chronic rhinosinusitis; coronavirus disease 2019; desensitization; device infection; eye allergy; health care access; health care policy; health care survey; human; immunosuppressive treatment; infection control; infection prevention; latex allergy; Letter; medical device complication; mutation; pandemic; phenotype; protective glasses; questionnaire; Asia; epidemiology; pandemic; Asia; COVID-19; Humans; Pandemics; SARS-CoV-2 |
John Wiley and Sons Inc |
01054538 |
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33948966 |
Letter |
Q1 |
3363 |
542 |
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221 |
Qu L.G., Perera M., Lawrentschuk N., Umbas R., Klotz L. |
57204687809;56544134500;57217501609;6602634832;55040556500; |
Scoping review: hotspots for COVID-19 urological research: what is being published and from where? |
2021 |
World Journal of Urology |
39 |
9 |
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3151 |
3160 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090474581&doi=10.1007%2fs00345-020-03434-2&partnerID=40&md5=02d48bd6f6edec3e634ad6f1c71c4628 |
Olivia Newton John Cancer Research Institute, Austin Health, Melbourne, VIC, Australia; Department of Surgery, University of Melbourne, Melbourne, VIC, Australia; Department of Urology, Austin Health, Heidelberg, VIC, Australia; Department of Urology, The Royal Melbourne Hospital, Melbourne, VIC, Australia; EJ Whitten Prostate Cancer Research Centre at Epworth, Melbourne, VIC, Australia; Department of Urology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada |
Qu, L.G., Olivia Newton John Cancer Research Institute, Austin Health, Melbourne, VIC, Australia, Department of Surgery, University of Melbourne, Melbourne, VIC, Australia, Department of Urology, Austin Health, Heidelberg, VIC, Australia; Perera, M., Olivia Newton John Cancer Research Institute, Austin Health, Melbourne, VIC, Australia, Department of Surgery, University of Melbourne, Melbourne, VIC, Australia; Lawrentschuk, N., Department of Surgery, University of Melbourne, Melbourne, VIC, Australia, Department of Urology, The Royal Melbourne Hospital, Melbourne, VIC, Australia, EJ Whitten Prostate Cancer Research Centre at Epworth, Melbourne, VIC, Australia; Umbas, R., Department of Urology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Klotz, L., Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada |
Purpose: Contemporary, original research should be utilised to inform guidelines in urology relating to the COVID-19 pandemic. This comprehensive review aimed to: identify all up-to-date original publications relating to urology and COVID-19, characterise where publications were from, and outline what topics were investigated. Methods: This review utilised a search strategy that assessed five electronic databases, additional grey literature, and global trial registries. All current published, in-press, and pre-print manuscripts were included. Eligible studies were required to be original research articles of any study design, reporting on COVID-19 or urology, in any of study population, intervention, comparison, or outcomes. Included studies were reported in a narrative synthesis format. Data were summarised according to primary reported outcome topic. A world heatmap was generated to represent where included studies originated from. Results: Of the 6617 search results, 48 studies met final inclusion criteria, including 8 pre-prints and 7 ongoing studies from online registries. These studies originated from ten countries according to first author affiliation. Most studies originated from China (n = 13), followed by Italy (n = 12) and USA (n = 11). Topics of the study included pathophysiological, administrative, and clinical fields: translational (n = 14), COVID-19-related outcomes (n = 5), urology training (n = 4), telemedicine (n = 7), equipment and safety (n = 2), urology in general (n = 4), uro-oncology (n = 3), urolithiasis (n = 1), and kidney transplantation (n = 8). Conclusion: This review has outlined available original research relevant to COVID-19 and urology from the international community. This summary may serve as a guide for future research priorities in this area. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature. |
COVID-19; Kidney transplantation; Telemedicine; Training; Uro-oncology; Urology |
epidemiology; global health; human; kidney transplantation; medical research; oncology; organization and management; prevention and control; procedures; publishing; telemedicine; urology; Biomedical Research; COVID-19; Global Health; Humans; Kidney Transplantation; Medical Oncology; Publishing; SARS-CoV-2; Telemedicine; Urology |
Springer Science and Business Media Deutschland GmbH |
07244983 |
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32909171 |
Article |
Q1 |
1552 |
2143 |
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223 |
Razeghian E., Margiana R., Chupradit S., Bokov D.O., Abdelbasset W.K., Marofi F., Shariatzadeh S., Tosan F., Jarahian M. |
57223052224;56685900600;57211329338;56845561300;57208873763;57199650994;57225946579;57216155951;16241593900; |
Mesenchymal Stem/Stromal Cells as a Vehicle for Cytokine Delivery: An Emerging Approach for Tumor Immunotherapy |
2021 |
Frontiers in Medicine |
8 |
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721174 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114747651&doi=10.3389%2ffmed.2021.721174&partnerID=40&md5=eb488365f37edbafb0ec0a51d29dbfc9 |
Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology (NIGEB), Tehran, Iran; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia; Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand; Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation; Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation; Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran; Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany |
Razeghian, E., Human Genetics Division, Medical Biotechnology Department, National Institute of Genetics Engineering and Biotechnology (NIGEB), Tehran, Iran; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo Hospital, The National Referral Hospital, Central Jakarta, Indonesia, Master's Programme Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Chupradit, S., Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand; Bokov, D.O., Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation, Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation; Abdelbasset, W.K., Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia, Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt; Marofi, F., Immunology Research Center (IRC), Tabriz University of Medical Sciences, Tabriz, Iran; Shariatzadeh, S., Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Tosan, F., Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran; Jarahian, M., Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, Heidelberg, Germany |
Pro-inflammatory cytokines can effectively be used for tumor immunotherapy, affecting every step of the tumor immunity cycle. Thereby, they can restore antigen priming, improve the effector immune cell frequencies in the tumor microenvironment (TME), and eventually strengthen their cytolytic function. A renewed interest in the anticancer competencies of cytokines has resulted in a substantial promotion in the number of trials to address the safety and efficacy of cytokine-based therapeutic options. However, low response rate along with the high toxicity associated with high-dose cytokine for reaching desired therapeutic outcomes negatively affect their clinical utility. Recently, mesenchymal stem/stromal cells (MSCs) due to their pronounced tropism to tumors and also lower immunogenicity have become a promising vehicle for cytokine delivery for human malignancies. MSC-based delivery of the cytokine can lead to the more effective immune cell-induced antitumor response and provide sustained release of target cytokines, as widely evidenced in a myriad of xenograft models. In the current review, we offer a summary of the novel trends in cytokine immunotherapy using MSCs as a potent and encouraging carrier for antitumor cytokines, focusing on the last two decades' animal reports. © Copyright © 2021 Razeghian, Margiana, Chupradit, Bokov, Abdelbasset, Marofi, Shariatzadeh, Tosan and Jarahian. |
cytokine; cytokine delivery; gene therapy; mesenchymal stem/stromal cells; tumor-immunotherapy |
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Frontiers Media S.A. |
2296858X |
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Review |
Q1 |
1388 |
2608 |
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262 |
Uchihara Y., Permata T.B.M., Sato H., Shibata A. |
57221723636;57197808751;55697961900;8323572900; |
Modulation of immune responses by DNA damage signaling |
2021 |
DNA Repair |
104 |
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103135 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106368761&doi=10.1016%2fj.dnarep.2021.103135&partnerID=40&md5=6d7c9e9634795d347738b7c970442465 |
Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan; Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Department of Radiation Oncology, Gunma University, Gunma, Japan |
Uchihara, Y., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan; Permata, T.B.M., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Sato, H., Department of Radiation Oncology, Gunma University, Gunma, Japan; Shibata, A., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan |
An accumulation of evidence indicates the importance of DNA damage signaling in modulating immune responses. Indeed, understanding the mechanism that underlies signal transduction originating from DNA damage is vital to overcoming refractory cancer, particularly when cancer immune therapy is applied in combination with DNA damage-dependent radio/chemotherapy. In addition, immune-associated responses to such signals can aggravate the symptoms of infections, allergies, autoimmune disease, and aging. In this review, we discuss how cells transduce signals, triggered by DNA damage, from their origins to neighboring cells and how this affects immune and inflammatory responses. © 2021 Elsevier B.V. |
Cancer therapy; DNA damage signaling; Immune crosstalk; Immune-associated disease; Inflammation |
nucleic acid; DNA; Article; cancer immunotherapy; DNA damage response; down regulation; human; immune response; immunomodulation; immunopathology; immunoregulation; inflammation; priority journal; signal transduction; animal; DNA damage; DNA repair; immunity; immunology; metabolism; neoplasm; signal transduction; Animals; DNA Damage; DNA Repair; DNA, Neoplasm; Humans; Immunity; Inflammation; Neoplasms; Signal Transduction |
Elsevier B.V. |
15687864 |
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34029876 |
Article |
Q1 |
2359 |
1004 |
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266 |
Akada J., Tshibangu-Kabamba E., Tuan V.P., Kurogi S., Matsuo Y., Ansari S., Doohan D., Phuc B.H., Subsomwong P., Waskito L.A., Binh T.T., Nguyen L.T., Khien V.V., Dung H.D.Q., Miftahussurur M., Syam A.F., Tshering L., Vilaichone R.-K., Mahachai V., Ratanachu-ek T., Shrestha P.K., Yee T.T., Htet K., Aftab H., Matsuhisa T., Uchida T., Okimoto T., Mizukami K., Kodama M., Murakami K., Takahashi N., Yamaoka Y. |
6506986959;57218760439;57195367045;57195277760;55567953900;55523204000;57204644036;57222165127;57113712700;57192177367;55415987700;35285702000;6507745643;56681908900;56323903000;8443384400;57211294242;6701788898;7003739875;6507122700;8099897200;57211455497;57241639000;55359226800;7005493709;35286123100;7005300232;7005239531;35285903900;57214336895;7403938865;55183784100; |
Serum Helicobacter pylori antibody reactivity in seven Asian countries using an automated latex aggregation turbidity assay |
2021 |
Journal of Gastroenterology and Hepatology (Australia) |
36 |
8 |
|
2198 |
2209 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102320750&doi=10.1111%2fjgh.15467&partnerID=40&md5=71760e350adacfbf3a65094e953e8182 |
Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan; Clinical Laboratory Center, Oita University Hospital, Yufu, Japan; Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh City, Viet Nam; Department of Hepatogastroenterology, 108 Military Central Hospital, Hanoi, Viet Nam; Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia; Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Airlangga University, Surabaya, Indonesia; Division of Gastroenterology, Department of Intestinal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Surgery, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan; Gastroenterology Unit, Digestive Diseases Research Center, Thammasat University Hospital, Khlong Luang, Thailand; Department of Medicine, Chulabhorn International College of Medicine, Thammasat University Hospital, Khlong Luang, Thailand; GI and Liver Center, Bangkok Medical Center, Bangkok, Thailand; Department of Surgery, Rajavithi Hospital, Bangkok, Thailand; Department of Gastroenterology, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Kathmandu, Nepal; Department of GI and HBP Surgery, No (2) Defense Service General Hospital, Nay Pyi Taw, Myanmar; Department of GI and HBP Surgery, No (1) Defense Service General Hospital, Mingaladon, Myanmar; Department of Gastroenterology, Dhaka Medical Collage and Hospital, Dhaka, Bangladesh; Department of Gastroenterology, Tama-Nagayama University Hospital, Nippon Medical School, Tama, Japan; Department of Molecular Pathology, Faculty of Medicine, Oita University, Yufu, Japan; Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan; Faculty of Welfare and Health Science, Oita University, Yufu, Japan; Global Oita Medical Advanced Research Center for Health, Oita University, Yufu, Japan; Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX, United States |
Akada, J., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan; Tshibangu-Kabamba, E., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan; Tuan, V.P., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan, Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh City, Viet Nam; Kurogi, S., Clinical Laboratory Center, Oita University Hospital, Yufu, Japan, Department of Molecular Pathology, Faculty of Medicine, Oita University, Yufu, Japan; Matsuo, Y., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan; Ansari, S., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan; Doohan, D., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan, Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia; Phuc, B.H., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan; Subsomwong, P., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan; Waskito, L.A., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan, Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia; Binh, T.T., Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh City, Viet Nam; Nguyen, L.T., Department of Hepatogastroenterology, 108 Military Central Hospital, Hanoi, Viet Nam; Khien, V.V., Department of Hepatogastroenterology, 108 Military Central Hospital, Hanoi, Viet Nam; Dung, H.D.Q., Department of Endoscopy, Cho Ray Hospital, Ho Chi Minh City, Viet Nam; Miftahussurur, M., Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia, Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Airlangga University, Surabaya, Indonesia; Syam, A.F., Division of Gastroenterology, Department of Intestinal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Tshering, L., Department of Surgery, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan; Vilaichone, R.-K., Gastroenterology Unit, Digestive Diseases Research Center, Thammasat University Hospital, Khlong Luang, Thailand, Department of Medicine, Chulabhorn International College of Medicine, Thammasat University Hospital, Khlong Luang, Thailand; Mahachai, V., GI and Liver Center, Bangkok Medical Center, Bangkok, Thailand; Ratanachu-ek, T., Department of Surgery, Rajavithi Hospital, Bangkok, Thailand; Shrestha, P.K., Department of Gastroenterology, Maharajgunj Medical Campus, Tribhuvan University Teaching Hospital, Kathmandu, Nepal; Yee, T.T., Department of GI and HBP Surgery, No (2) Defense Service General Hospital, Nay Pyi Taw, Myanmar; Htet, K., Department of GI and HBP Surgery, No (1) Defense Service General Hospital, Mingaladon, Myanmar; Aftab, H., Department of Gastroenterology, Dhaka Medical Collage and Hospital, Dhaka, Bangladesh; Matsuhisa, T., Department of Gastroenterology, Tama-Nagayama University Hospital, Nippon Medical School, Tama, Japan; Uchida, T., Department of Molecular Pathology, Faculty of Medicine, Oita University, Yufu, Japan; Okimoto, T., Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan; Mizukami, K., Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan; Kodama, M., Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan, Faculty of Welfare and Health Science, Oita University, Yufu, Japan; Murakami, K., Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu, Japan; Takahashi, N., Clinical Laboratory Center, Oita University Hospital, Yufu, Japan; Yamaoka, Y., Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Japan, Global Oita Medical Advanced Research Center for Health, Oita University, Yufu, Japan, Department of Medicine, Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, TX, United States |
Background and Aim: To determine the application range of diagnostic kits utilizing anti-Helicobacter pylori antibody, we tested a newly developed latex aggregation turbidity assay (latex) and a conventional enzyme-linked immunosorbent assay (E-plate), both containing Japanese H. pylori protein lysates as antigens, using sera from seven Asian countries. Methods: Serum samples (1797) were obtained, and standard H. pylori infection status and atrophy status were determined by culture and histology (immunohistochemistry) using gastric biopsy samples from the same individuals. The two tests (enzyme-linked immunosorbent assay and latex) were applied, and receiver operating characteristics analysis was performed. Results: Area under the curve (AUC) from the receiver operating characteristic of E-plate and latex curves were almost the same and the highest in Vietnam. The latex AUC was slightly lower than the E-plate AUC in other countries, and the difference became statistically significant in Myanmar and then Bangladesh as the lowest. To consider past infection cases, atrophy was additionally evaluated. Most of the AUCs decreased using this atrophy-evaluated status; however, the difference between the two kits was not significant in each country, but the latex AUC was better using all samples. Practical cut-off values were 3.0 U/mL in the E-test and 3.5 U/mL in the latex test, to avoid missing gastric cancer patients to the greatest extent possible. Conclusions: The kits were applicable in all countries, but new kits using regional H. pylori strains are recommended for Myanmar and Bangladesh. Use of a cut-off value lower than the best cut-off value is essential for screening gastric cancer patients. © 2021 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd |
Asia; ELISA; Helicobacter pylori; Latex aggregation turbidity assay; Serum antibody |
antigen; bacterium antibody; immunoglobulin G; protein hydrolysate; bacterium antibody; adult; antibody blood level; Article; Asia; bacterial strain; bacterium culture; Bangladesh; Bhutan; cancer patient; cancer screening; controlled study; diagnostic accuracy; diagnostic test; evaluation study; female; Helicobacter infection; Helicobacter pylori; histopathology; human; human tissue; immunohistochemistry; Indonesia; infection rate; Japan; latex aggregation turbidity assay; major clinical study; male; marginal zone lymphoma; middle aged; Myanmar; Nepal; nonhuman; plate ELISA; predictive value; receiver operating characteristic; reference value; sensitivity and specificity; serum; statistical significance; stomach atrophy; stomach biopsy; stomach cancer; Viet Nam; aged; atrophy; biopsy; bloo |
John Wiley and Sons Inc |
08159319 |
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33609333 |
Article |
Q1 |
1214 |
3242 |
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