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Yuliwulandari R., Shin J.G., Kristin E., Suyatna F.D., Prahasto I.D., Prayuni K., Mahasirimongkol S., Cavallari L.H., Mitropoulou C., Patrinos G.P., Hao J., Williams M.S., Snyder S.R. |
23098874600;56031235700;6504458442;56039633100;57222660319;57190022456;14632559000;8396168500;37001846100;6603726539;57194283820;57203332674;7401687524; |
Cost-effectiveness analysis of genotyping for HLA-B*15:02 in Indonesian patients with epilepsy using a generic model |
2021 |
Pharmacogenomics Journal |
21 |
4 |
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476 |
483 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103643380&doi=10.1038%2fs41397-021-00225-9&partnerID=40&md5=927cb9a5fa739ff5a932d25eb4459bd0 |
Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta Pusat, Indonesia; Genetic Research Center, YARSI Research Institute, YARSI University, Jakarta Pusat, Indonesia; Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea; Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, South Korea; Department of Pharmacology and Therapy, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Department of Pharmacology & Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Medical Genetics Section, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand; Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, United States; The Golden Helix Foundation, London, United Kingdom; Department of Pharmacy, University of Patras, Patras, Greece; Department of Pathology, United Arab Emirates University College of Medicine and Health Sciences, Al-Ain, United Arab Emirates; Department of Population Health Sciences, Geisinger, Danville, PA, United States; Genomic Medicine Institute, Geisinger, Danville, PA, United States; Health Policy & Behavioral Sciences, Georgia State University, Atlanta, GA, United States |
Yuliwulandari, R., Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta Pusat, Indonesia, Genetic Research Center, YARSI Research Institute, YARSI University, Jakarta Pusat, Indonesia; Shin, J.G., Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Busan, South Korea, Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, South Korea; Kristin, E., Department of Pharmacology and Therapy, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Suyatna, F.D., Department of Pharmacology & Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Prahasto, I.D., Department of Pharmacology and Therapy, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Prayuni, K., Genetic Research Center, YARSI Research Institute, YARSI University, Jakarta Pusat, Indonesia; Mahasirimongkol, S., Medical Genetics Section, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand; Cavallari, L.H., Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL, United States; Mitropoulou, C., The Golden Helix Foundation, London, United Kingdom; Patrinos, G.P., Department of Pharmacy, University of Patras, Patras, Greece, Department of Pathology, United Arab Emirates University College of Medicine and Health Sciences, Al-Ain, United Arab Emirates; Hao, J., Department of Population Health Sciences, Geisinger, Danville, PA, United States; Williams, M.S., Genomic Medicine Institute, Geisinger, Danville, PA, United States; Snyder, S.R., Health Policy & Behavioral Sciences, Georgia State University, Atlanta, GA, United States |
Carbamazepine (CBZ)-induced Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are strongly associated with the HLA-B*15:02 allele. Screening HLA-B*15:02 before CBZ administration might prevent CBZ-induced SJS/TEN by enabling clinicians to prescribe alternative therapy for positive patients. Similar to other Southeastern Asian countries, HLA-B*15:02 is highly prevalent in Indonesia. Therefore, we assessed the economic value of HLA-B*15:02 screening before CBZ prescription to patients with epilepsy in Indonesia. A generic cost-effectiveness model and decision support tool, developed to enable users to perform an initial cost-effectiveness analysis from a healthcare provider/payer perspective, were used to assess the value of HLA-B*15:02 genotyping. The incremental cost-effectiveness ratio of adopting universal HLA-B*15:02 screening was 656,444,671 Indonesian Rupiah (IDR)/quality-adjusted life year (QALY) gained for patients compared with 2,634,975,574 IDR/QALY gained for providing valproic acid (alternative drug) without screening. Thus, neither HLA-B*15:02 screening nor substitution with VPA meets the Indonesian threshold for cost effectiveness. However, the improved outcomes with this test in other Asian countries may inform the desirability of implementation in Indonesia even with suboptimal cost-effectiveness. © 2021, The Author(s), under exclusive licence to Springer Nature Limited. |
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anticonvulsive agent; carbamazepine; HLA B antigen; valproic acid; anticonvulsive agent; carbamazepine; HLA B15 antigen; aged; Article; cost effectiveness analysis; epilepsy; epileptic patient; female; genotyping; human; Indonesian; Javanese (people); major clinical study; male; predictive value; prevalence; quality adjusted life year; sensitivity analysis; sensitivity and specificity; Stevens Johnson syndrome; Sundanese (people); toxic epidermal necrolysis; adult; allele; Asian; cost benefit analysis; epilepsy; genetic predisposition; genetic screening; genetics; genotype; Indonesia; procedures; risk factor; Adult; Alleles; Anticonvulsants; Asians; Carbamazepine; Cost-Benefit Analysis; Epilepsy; Female; Genetic Predisposition to Disease; Genetic Testing; Genotype; HLA-B15 Antigen; Humans; |
Springer Nature |
1470269X |
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33824430 |
Article |
Q2 |
804 |
6015 |
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328 |
Sihotang R.C., Alvonico T., Taher A., Birowo P., Rasyid N., Atmoko W. |
57216755881;57216743520;7005269743;6504153311;56245069300;57193125664; |
Premature ejaculation in patients with lower urinary tract symptoms: a systematic review |
2021 |
International Journal of Impotence Research |
33 |
5 |
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516 |
524 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084492871&doi=10.1038%2fs41443-020-0298-5&partnerID=40&md5=243ef2c5fa8e96c70ec2e3eb9ca5b534 |
Faculty of Medicine, Universitas Indonesia, No. 6, Salemba Raya Road, DKI Jakarta, 10430, Indonesia; Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia |
Sihotang, R.C., Faculty of Medicine, Universitas Indonesia, No. 6, Salemba Raya Road, DKI Jakarta, 10430, Indonesia; Alvonico, T., Faculty of Medicine, Universitas Indonesia, No. 6, Salemba Raya Road, DKI Jakarta, 10430, Indonesia; Taher, A., Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia; Birowo, P., Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia; Rasyid, N., Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia; Atmoko, W., Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia |
Lower urinary tract symptoms (LUTS) refer to a group of symptoms related to bladder, prostate, and urethra. LUTS are common in men and the severity increases with age. LUTS are frequently associated with sexual dysfunction, such as premature ejaculation (PE), standing as the most common sexual dysfunction in men. Both LUTS and PE cause distress and dissatisfaction for the patient and his partner. This systematic review aims to determine the relationship between LUTS and PE in men. Two reviewers independently conduct a literature search in five online databases (PubMed, Scopus, Proquest, ClinicalKey, and ScienceDirect). In addition, reviewers also reviewed the reference list of chosen articles to identify additional relevant studies. Twelve articles were included in this systematic review that consists of one cohort study and 11 cross-sectional studies. The total scores of each identified study ranged from “poor” to “good.” The prevalence of PE in LUTS ranged from 12 to 77%. Most of the studies showed a significant relationship between LUTS and PE. PE is more common in older age with the peak prevalence in age of 60–69 years old. There is a possible association between PE and LUTS. Further research using cohort or case-control study design on this topic is needed. © 2020, The Author(s), under exclusive licence to Springer Nature Limited. |
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age; human; International Prostate Symptom Score; male; outcome assessment; premature ejaculation; prevalence; prostatectomy; Review; systematic review; urinary tract infection; aged; case control study; cohort analysis; complication; cross-sectional study; ejaculation; lower urinary tract symptom; middle aged; premature ejaculation; Aged; Case-Control Studies; Cohort Studies; Cross-Sectional Studies; Ejaculation; Humans; Lower Urinary Tract Symptoms; Male; Middle Aged; Premature Ejaculation |
Springer Nature |
09559930 |
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32393845 |
Review |
Q2 |
508 |
9947 |
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787 |
Rahman I.A., Rasyid N., Birowo P., Atmoko W. |
57211646827;56245069300;6504153311;57193125664; |
Effects of renal transplantation on erectile dysfunction: a systematic review and meta-analysis |
2021 |
International Journal of Impotence Research |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107770401&doi=10.1038%2fs41443-021-00419-6&partnerID=40&md5=6fab70d2b92ac45bd379994f51e6be3a |
Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rahman, I.A., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rasyid, N., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Birowo, P., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Atmoko, W., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Erectile dysfunction (ED) is a major global health burden commonly observed in patients with end-stage renal disease (ESRD). Although renal transplantation improves the problem in some patients, it persists in ≈20–50% of recipients. Studies regarding the effects of kidney transplantation on ED present contradictory findings. We performed a systematic review to summarise the effects of kidney transplantation on ED. A systematic literature search was performed across PubMed, Cochrane, and Scopus databases in April 2020. We included all prospective studies that investigated the pre and posttransplant international index of erectile function (IIEF-5) scores in recipients with ED. Data search in PubMed and Google Scholar produced 1326 articles; eight were systematically reviewed with a total of 448 subjects. Meta-analysis of IIEF-5 scores showed significant improvements between pre and post transplantation. Our findings confirm that renal transplantation improves erectile function. Furthermore, transplantation also increases testosterone level. However, the evidence is limited because of the small number of studies. Further studies are required to investigate the effects of renal transplantation on erectile function. © 2021, The Author(s). |
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Springer Nature |
09559930 |
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508 |
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261 |
Pravian D., Soesanto A.M., Ambari A.M., Kuncoro B.R.M.A.S., Dwiputra B., Muliawan H.S., Sukmawan R. |
57223935749;56374199000;57189576921;57223920990;57195383994;57203644653;8651025300; |
The effect of external counterpulsation on intrinsic myocardial function evaluated by speckle tracking echocardiography in refractory angina patients: a randomized controlled trial |
2021 |
International Journal of Cardiovascular Imaging |
37 |
8 |
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2483 |
2490 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106531230&doi=10.1007%2fs10554-021-02289-x&partnerID=40&md5=205259fb7afb6a50c7b9b375ac603918 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Pravian, D., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Soesanto, A.M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Ambari, A.M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Kuncoro, B.R.M.A.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Dwiputra, B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Muliawan, H.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Sukmawan, R., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
External Counterpulsation (ECP) is one of the therapeutic options in patients with refractory angina inadequately controlled by medical, interventional, or surgical therapy. The 2D Speckle Tracking Echocardiography (2D-STE) method is considered superior in assessing clinical improvement. We would like to evaluate any improvement of myocardial intrinsic function using 2D-STE in patients underwent standard ECP protocol (35 sessions). We conducted a double-blind randomized controlled trial. Patients with refractory angina who could not be revascularized conventionally were randomized into two groups: (1) the ECP group (300 mmHg) and (2) the Sham/control group (75 mmHg). ECP standard therapy was given for 35 sessions (1 h/day/session). The 2D-STE data, including longitudinal strain and post systolic index (PSI) were obtained before and after therapy. 43 subjects were analyzed, with 22 subjects in ECP group and 21 control subjects (Sham group). A homogenous baseline strain was found either globally (12.42 ± 4.55 vs 12.00 ± 4.92 [− %]; P = 0.774) or segmentally/regionally (12.63 (0.01–25.16) vs 12.43 (0.01–27.20) [− %]; P = 0.570). There was no statistically significant improvement between groups in the left ventricle longitudinal strain globally (P = 0.535) and segmentally/regionally (P = 0.434). PSI parameters showed improvement in the ECP group (P = 0.049), and segments with PSI ≥ 20% seemed to improve longitudinal strains in the ECP group after therapy (P = 0.042). In conclusion, 35 ECP therapy sessions did not improve either global or segmental/regional left ventricular mechanical function in patients with refractory angina. However, the mechanical function of myocardial segments with PSS tends to improve after ECP therapy. © 2021, The Author(s), under exclusive licence to Springer Nature B.V. |
2D speckle tracking echocardiography; External counterpulsation; Post systolic index; Refractory angina; Strain |
adult; aged; angina pectoris; Article; cardiovascular parameters; clinical article; clinical outcome; controlled study; counterpulsation; double blind procedure; female; follow up; heart function; heart left ventricle enddiastolic diameter; heart left ventricle endsystolic diameter; human; left ventricular global longitudinal strain; male; middle aged; post systolic index; post systolic shortening; randomized controlled trial; tricuspid annular plane systolic excursion; two dimensional speckle tracking echocardiography |
Springer Science and Business Media B.V. |
15695794 |
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34037889 |
Article |
Q2 |
726 |
6821 |
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680 |
Sandora N., Putra M.A., Nurhayati R.W., Suwarti, Nauli R., Kusuma T.R., Fitria N.A., Ardiansyah, Muttaqin C., Makdinata W., Alwi I. |
57204103434;57215605850;55748436600;57212462722;57212478305;57222897694;57148498800;57223036386;57226442135;57223405655;15055173800; |
Characterisation of the single-cell human cardiomyocytes taken from the excess heart tissue of the right ventricular outlet in congenital heart disease |
2021 |
Cell and Tissue Banking |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118214107&doi=10.1007%2fs10561-021-09970-4&partnerID=40&md5=2c4fad90958206777aa1ef5e9ea1e5ec |
Faculty of Medicine, Universitas Riau, Pekanbaru, 28293, Indonesia; Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Sandora, N., Faculty of Medicine, Universitas Riau, Pekanbaru, 28293, Indonesia, Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Putra, M.A., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Nurhayati, R.W., Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Suwarti, Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Nauli, R., Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Kusuma, T.R., Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Fitria, N.A., Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Ardiansyah, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Muttaqin, C., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Makdinata, W., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Alwi, I., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Cardiovascular disease is the second highest cause of death across the globe. Myocardial infarction is one of the heart diseases that cause permanent impairment of the heart wall leads to heart failure. Cellular therapy might give hope to regenerate the damaged myocardium. Single cells isolated from an excess heart tissue obtained from the correction of the right ventricular hypertrophy in patients with Tetralogy of Fallot for future heart study were investigated. Methods: Once resected, the heart tissues were transported at 37 °C, in Dulbecco's Modified Eagle's medium/ DMEM (4.5 g.L−1, antibiotic–antimycotic 3x, PRP10% (v/v)), to reach the lab within 30 min, weighted and grouped into less than 500 mg and more than 1000 mg (n = 4). Each sample was digested with 250 U.mL−1 Collagenase type V and 4U.mL−1 Proteinase XXIV in the MACS™ C-tube (Milltenyi, Germany), then dissociated using the MACS™ Octo Dissociator with Heater (Milltenyi, Germany) for 60 min at 37 °C. Results: All cells isolated were rod-shaped cells; viability was up to 90%. The cell density obtained from the 500 mg group were 4,867 ± 899 cells.mg−1 tissue weight, significantly higher compared to the 1,000 mg group; had 557 ± 490 cells.mg−1 tissue weight (mean of (n = 3) ± 95% C.l). The isolated cells were analyzed using FACs BD Flowcytometer, expressed cTnT + 13.38%, PECAM-1 + /VCAM-1- 32.25%, cKit + 7.85%, ICAM + 85.53%, indicating the cardiomyocyte progenitor cells. Conclusion: Cardiomyocytes taken from the wasted heart tissue might be a candidate of cardiomyocytes source to study interventions to the heart as it contained up to 13.38% cardiomyocytes, and 32.25% of cardiac progenitor cells. Moreover, perhaps when cardiac cell therapy needs autologous cardiomyocytes, less than 500 mg tissue weight can be considered as sufficient. © 2021, The Author(s), under exclusive licence to Springer Nature B.V. |
Cardiac progenitor cells; Cardiomyocyte isolation; Right ventricular resection; Tetralogy of fallot; Waste heart tissue |
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Springer Science and Business Media B.V. |
13899333 |
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Article |
Q3 |
397 |
12196 |
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54 |
Harefa, Wijaya I.P., Muhadi, Rumende C.M., Nasution S.A., Koesnoe S., Marbun M.B., Shatri H. |
57298868100;57193731572;57189615533;14325966300;57189373134;26028015000;57195201827;28767986500; |
The association between 24-h blood pressure variability and major adverse cardiac events (MACE) in hospitalized patients with acute myocardial infarction: a retrospective cohort study |
2021 |
Egyptian Heart Journal |
73 |
1 |
88 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117340121&doi=10.1186%2fs43044-021-00213-1&partnerID=40&md5=c9f1acb17b55e567ab93cb770f13356a |
Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia |
Harefa, Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Wijaya, I.P., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Muhadi, Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Rumende, C.M., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Nasution, S.A., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Koesnoe, S., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Marbun, M.B., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia; Shatri, H., Department of Internal Medicine, Faculty of Medicine, University of Indonesia/Dr, CiptoMangunkusumo National Hospital Jakarta, Jakarta, Indonesia |
Background: Acute myocardial infarction (AMI) is major cardiovascular disease that causes high morbidity and mortality. In AMI, ischemia and necrosis affected some cardiomyocytes leading to a decrease in myocardial contractility which is followed by an acute proinflammation reaction and increased sympathetic tone. Meanwhile, high blood pressure variability (BPV) causing an increased left ventricular workload, heart rate, myocardial oxygen demand and induces proinflamations and endothelial dysfunction. Therefore a high BPV and its associated pathological effects are likely to aggravate the physiological function of the heart and affect the emergence of acute cardiac complications in AMI patients. This study aims to investigate the association’s between short-term BPV and major adverse cardiac events (MACE) in AMI patients. This retrospective cohort study used simple random sampling to identify AMI patients who were hospitalized at Cipto Mangunkusumo National Hospital between January 2018 and December 2019. Mann Withney was performed to investigate the association between BPV and MACE. Results: The average systolic BPV value which was calculated as standard deviation (SD) and average real variability (ARV) was higher in the MACE group than in the non-MACE group. Systolic SD and systolic ARV in the MACE group were 13.28 ± 5.41 mmHg and 9.88 ± 3.81 mmHg respectively. In the non-MACE group, systolic SD and systolic ARV were 10.76 (4.59–26.17) mmHg and 8.65 (3.22–19.35) mmHg respectively. There was no significant association between BPV and MACE. However, there were significant differences between systolic SD and systolic ARV in patients with hypertension who experienced MACE and patients without hypertension who experienced MACE. Conclusions: The BPV of AMI patients who experience MACE was higher than that of non-MACE AMI patients. There was no significant association between BPV and MACE during the acute phase of AMI. © 2021, The Author(s). |
Acute myocardial infarction; Average real variability; Blood pressure variability; Major adverse cardiac events |
acute heart infarction; adult; aged; Article; blood pressure monitoring; blood pressure variability; cohort analysis; controlled study; diastolic blood pressure; female; heart function; hospital patient; human; hypertension; major adverse cardiac event; major clinical study; male; retrospective study; systolic blood pressure |
Springer Science and Business Media Deutschland GmbH |
11102608 |
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Article |
Q3 |
212 |
18617 |
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59 |
Adriansyah I.A., Afriansyah A., Siregar M.A.R., Purnomo N., Mirza H., Seno D.H. |
57255172900;57190688768;57255058200;57255293100;57208513330;57255640300; |
Efficacy of holmium laser enucleation of the prostate in patients with detrusor underactivity: systematic review and meta-analysis |
2021 |
African Journal of Urology |
27 |
1 |
128 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114753119&doi=10.1186%2fs12301-021-00230-1&partnerID=40&md5=a5780c3ae26d7da14412977dd81e01f7 |
Department of Urology, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No. 71, Salemba, Jakarta Pusat, Jakarta, DKI Jakarta 10430, Indonesia; Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia |
Adriansyah, I.A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No. 71, Salemba, Jakarta Pusat, Jakarta, DKI Jakarta 10430, Indonesia; Afriansyah, A., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia; Siregar, M.A.R., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia; Purnomo, N., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia; Mirza, H., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia; Seno, D.H., Division of Urology, Department of Surgery, Persahabatan Hospital, Jl. Persahabatan Raya No. 1, Pulo Gadung, Jakarta Timur, Jakarta, DKI Jakarta 13230, Indonesia |
Background: Benign prostatic hyperplasia (BPH) is commonly found in the aging male. Treatment of BPH can be in form of conservative or surgical intervention. Transurethral resection of the prostate (TURP) is the gold-standard treatment for BPH according to the guideline. However, there is no evidence that there is a benefit for TURP in patients with detrusor underactivity (DUA). Holmium laser enucleation (HoLEP) is theorized to have a better outcome due to its property of complete prostate enucleation. Therefore, this meta-analysis aims to determine the benefit of HoLEP for BPH patients with DUA. Main body: We performed systematic literature searching from five databases including PubMed, Scopus, Embase, Science Direct, and Web of Science for articles up to 31 December 2020 for relevant studies. A total of five articles are eligible for this meta-analysis. A total of 2.180 subjects participated in all of the studies included. Two studies comparing patients with and without DUA that was treated with HoLEP, two studies comparing HoLEP with other surgical approaches for BPH, and one study comparing both parameters. IPSS score reduction is significantly higher in the patients with DUA (Mean Difference = 3.28, 95% CI 1.91 to 4.64, p < 0.01). Qmax and PVR are not significantly different between both groups. HoLEP also showed better improvement in IPSS and Qmax compared to TURP (IPSS: Mean Difference = -4.80, 95% CI − 7.83 to − 1.77, p = 0.002; Qmax: Mean Difference = 4.20, 95% CI 0.58 to 7.82, p = 0.02) and PVP (IPSS: Mean Difference = − 2.47, 95% CI − 4.47 to − 0.47, p = 0.02; Qmax: Mean Difference = 2.31, 95% CI 0.34 to 4.28, p = 0.02). Conclusion: HoLEP showed better improvement in IPSS scores in patients with DUA. HoLEP can be considered to be performed in the BPH patients with DUA for better outcomes for the patients. © 2021, The Author(s). |
Benign prostatic hyperplasia; Detrusor underactivity; HoLEP; Laser enucleation; Surgical outcome |
clinical effectiveness; Embase; enucleation; human; hypotonic bladder; information retrieval; intermethod comparison; International Prostate Symptom Score; laser surgery; male; measurement; Medline; meta analysis; Newcastle-Ottawa scale; postvoid residual urine volume; prostate hypertrophy; prostate surgery; randomized controlled trial (topic); Review; ScienceDirect; Scopus; surgical approach; systematic review; transurethral resection; Web of Science |
Springer Science and Business Media Deutschland GmbH |
11105704 |
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Review |
Q4 |
174 |
21103 |
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60 |
Satjakoesoemah A.I., Alfarissi F., Wahyudi I., Rodjani A., Rasyid N. |
57189614677;57197871808;36341995300;6504653529;56245069300; |
Factors related to the success rate of pediatric extracorporeal shock wave lithotripsy (ESWL) in Cipto Mangunkusumo Hospital: an 8-year single-center experience |
2021 |
African Journal of Urology |
27 |
1 |
92 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114055813&doi=10.1186%2fs12301-021-00187-1&partnerID=40&md5=a186e20e8260339cc3e9b7f5ff9c9867 |
Department of Urology, Faculty of Medicine, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Pangeran Diponegoro Street No. 71, Senen Subdistrict, Central Jakarta District, Jakarta, 10430, Indonesia |
Satjakoesoemah, A.I., Department of Urology, Faculty of Medicine, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Pangeran Diponegoro Street No. 71, Senen Subdistrict, Central Jakarta District, Jakarta, 10430, Indonesia; Alfarissi, F., Department of Urology, Faculty of Medicine, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Pangeran Diponegoro Street No. 71, Senen Subdistrict, Central Jakarta District, Jakarta, 10430, Indonesia; Wahyudi, I., Department of Urology, Faculty of Medicine, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Pangeran Diponegoro Street No. 71, Senen Subdistrict, Central Jakarta District, Jakarta, 10430, Indonesia; Rodjani, A., Department of Urology, Faculty of Medicine, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Pangeran Diponegoro Street No. 71, Senen Subdistrict, Central Jakarta District, Jakarta, 10430, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Pangeran Diponegoro Street No. 71, Senen Subdistrict, Central Jakarta District, Jakarta, 10430, Indonesia |
Background: ESWL is still considered as the first favorable therapeutic option for urinary stone disease with acceptable effectivity. However, factors associated with favorable outcome have not been widely studied in pediatrics due to the small number of urinary stone prevalence. The aim of this study is to evaluate the factors associated with the success rate of pediatric ESWL in our center according to immediate stone-free rate and 3-month stone-free rates. Methods: This is a retrospective cohort study of children less than 18 years who had ESWL for urolithiasis from January 2008 until August 2015. Patient’s characteristics including age, gender, BMI, stone location, stone length, stone burden, stone opacity, and number of ESWL sessions were gathered from the medical record. Nutritional status was determined according to the Centers for Disease Control and Prevention BMI curve. The outcome of this study was the factors related to the success rate in pediatric ESWL. Results: Extracorporeal shock wave lithotripsy was done for 36 patients and 39 renal units (RUs) with mean age of 13.7 ± 4.3 years old, height of 1480 ± 16.0 cm, and BMI of 20.0 ± 3. Of 36 patients included, 39 renoureteral units (RUs) and 46 ESWL sessions were recorded. The mean overall treatment was 1.2 ± 0.5 sessions with mean stone length of 11.1 ± 6.3 mm and stone burden of 116.6 ± 130.3 mm2. Within 3 months of follow-up, we recorded that the overall 3-month success rate was 100%, while the overall 3-month stone-free rate was 66.7%. Stone length (p < 0.001 and p < 0.001), stone perpendicular length (p < 0.001 and p < 0.001), and stone burden (p < 0.001 and p = 0.001) were found to be significantly associated with immediate success and 3-month stone-free status, respectively. Conclusions: ESWL is an effective and safe modality to treat pediatric urolithiasis cases. Stone length, stone perpendicular length, and stone burden were found to be associated with immediate success and 3-month stone-free status after pediatric ESWL treatment. © 2021, The Author(s). |
ESWL; Pediatric; Stone-free rate; Success rate; Urinary stone disease; Urolithiasis |
adolescent; age; Article; body mass; clinical article; cohort analysis; evaluation study; extracorporeal shock wave lithotripsy; factor analysis; female; follow up; gender; hospital; human; male; nutritional status; outcome assessment; public health service; retrospective study; urolithiasis |
Springer Science and Business Media Deutschland GmbH |
11105704 |
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Article |
Q4 |
174 |
21103 |
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62 |
Prasetyo M., Mongan A.E., Chozie N.A., Prihartono J., Setiawan S.I. |
57192905252;57226385960;57194329830;6602605635;57195939543; |
Hemosiderin deposition evaluation in hemophilic ankle joints: association between US finding and gradient-recalled echo MR imaging sequence |
2021 |
Insights into Imaging |
12 |
1 |
107 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111352122&doi=10.1186%2fs13244-021-01050-1&partnerID=40&md5=7acc2e0c4841079a7e9e49379be1ff9e |
Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jl. Diponegoro No.71, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Department of Pediatric, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Departement of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Prasetyo, M., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jl. Diponegoro No.71, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Mongan, A.E., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jl. Diponegoro No.71, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Chozie, N.A., Department of Pediatric, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Prihartono, J., Departement of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiawan, S.I., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jl. Diponegoro No.71, Jakarta Pusat, DKI Jakarta 10430, Indonesia |
Background: Repeated bleeding in hemophilic arthropathy (HA) may result in severe degenerative changes and joint destruction. The gradient-recalled echo (GRE) sequence MR is proved to be the best method to detect hemosiderin deposition. However, MR is not widely available in developing countries, including Indonesia. Some studies have proposed ultrasonography (US) as an alternative tool in evaluating hemophilic joint. However, there is still some disagreement on the ability of US to detect hemosiderin deposition. Objective: To evaluate the association between US and GRE-sequence MR imaging in detecting hemosiderin deposition in hemophilic ankle joint. Material and methods: A total of 102 sites from 17 ankle joints of 11 boys with severe hemophilia A underwent US examination using a high-frequency linear array transducer. GRE-sequence MR examination was performed in sagittal view consistent with the sites scanned by US. Both examinations were performed on the same day, but MR interpretation was performed blindly at different times. The association between US and GRE-sequences in detecting hemosiderin deposition was analyzed using McNemar’s test. Results: Statistical analysis showed a significant association (p value < 0.001) between US and GRE MR in detecting hemosiderin deposition, but the association is weak (R = 0.26). Sensitivity and specificity of US for detecting hemosiderin deposition were 46.84% (95%CI: 35.51–58.40) and 95.65% (95%CI: 78.05–99.89), respectively, with positive predictive value 97.37% (95%CI: 84.29–99.61), negative predictive value 34.38% (95%CI: 29.50–39.60) and accuracy 57.84% (95%CI: 47.66–67.56). Conclusion: There was a weak association between US and GRE-sequences in detecting hemosiderin deposition of hemophilic ankle joint. © 2021, The Author(s). |
GRE MR imaging; Hemophilic arthropathy; Hemosiderin deposition; US |
gadolinium; hemosiderin; accuracy; adolescent; anisotropy; Article; child; clinical article; cross-sectional study; echography; gradient recalled echo; gray matter; hemophilic arthropathy; histopathology; human; image analysis; male; medial malleolus; nuclear magnetic resonance imaging; predictive value; sensitivity and specificity; synovectomy |
Springer Science and Business Media Deutschland GmbH |
18694101 |
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Article |
Q1 |
1405 |
2531 |
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78 |
Laurentius A., Mendel B., Prakoso R. |
57213147353;57221914088;57192893243; |
Clinical outcome of renin-angiotensin-aldosterone system blockers in treatment of hypertensive patients with COVID-19: a systematic review and meta-analysis |
2021 |
Egyptian Heart Journal |
73 |
1 |
13 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100576309&doi=10.1186%2fs43044-021-00135-y&partnerID=40&md5=09d9e73f520074123305d8d901cd705f |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pediatric Cardiology and Congenital Heart Defect Division, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Laurentius, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mendel, B., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prakoso, R., Pediatric Cardiology and Congenital Heart Defect Division, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Background: Novel coronavirus disease 2019 has been stated as global disease pandemic due to its rapid spread worldwide. Up to 30% of coronavirus disease 2019 patients with hypertension are more susceptible to death. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers have been used as primary line of medication for hypertension; nonetheless, conflicting data arises as numerous studies showed contradictory results. Main body: Aiming to show clinical outcome of renin-angiotensin-aldosterone system blockers in hospital treatment of hypertensive patients with coronavirus disease 2019, systematically searched literatures through five databases were intensively appraised using The Grading of Recommendations Assessment, Development and Evaluation checklists for cohort studies. Based on the result evaluation from retrospective cohorts involving more than 15,000 patients across Asia and other regions of the world, ten encompassed studies divided into two subgroups in this meta-review showed that in-hospital hypertensive coronavirus disease 2019 patients receiving antihypertensive drugs were associated with overall risk reduction in subgroup 1 (hazard ratio, HR = 0.96, 95% CI = 0.82–1.12) to no outcome association of all-cause mortalities in subgroup 2 (HR = 0.26, 95% CI = 0.19–0.34). All appraised studies in synergism showed that mortality outcomes were not augmented with the employment of either ACE inhibitor or ARB in subjects. Conclusion: Therefore, the results support recommendation by the American Heart Association not to discontinue angiotensin-converting enzyme inhibitor or angiotensin receptor blocker regimens in coronavirus disease 2019 patients with hypertension. © 2021, The Author(s). |
Angiotensin receptor blockers; Angiotensin-converting enzyme inhibitors; COVID-19; Hypertension; Outcome |
angiotensin receptor antagonist; dipeptidyl carboxypeptidase inhibitor; adult; aged; all cause mortality; clinical outcome; confidence interval; coronavirus disease 2019; data base; female; hazard ratio; human; hypertension; hypertensive patient; male; medical society; meta analysis; mortality; renin angiotensin aldosterone system; Review; risk reduction; systematic review |
Springer Science and Business Media Deutschland GmbH |
11102608 |
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Review |
Q3 |
212 |
18617 |
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