|
No records
|
|
270 |
Smith O.J., Wicaksana A., Davidson D., Spratt D., Mosahebi A. |
54881691700;57211445559;55553306500;7004394482;55985666400; |
An evaluation of the bacteriostatic effect of platelet-rich plasma |
2021 |
International Wound Journal |
18 |
4 |
|
448 |
456 |
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100215304&doi=10.1111%2fiwj.13545&partnerID=40&md5=1f9c16fc126205b4735c175e68af0b2e |
Department of Plastic Surgery, Royal Free Hospital, London, United Kingdom; Division of Surgery and Interventional Science, University College London, London, United Kingdom; Division of Plastic Surgery, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Microbial Diseases, Eastman Dental Institute, Faculty of Medical Sciences, University College London, London, United Kingdom |
Smith, O.J., Department of Plastic Surgery, Royal Free Hospital, London, United Kingdom, Division of Surgery and Interventional Science, University College London, London, United Kingdom; Wicaksana, A., Division of Surgery and Interventional Science, University College London, London, United Kingdom, Division of Plastic Surgery, Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Davidson, D., Microbial Diseases, Eastman Dental Institute, Faculty of Medical Sciences, University College London, London, United Kingdom; Spratt, D., Microbial Diseases, Eastman Dental Institute, Faculty of Medical Sciences, University College London, London, United Kingdom; Mosahebi, A., Department of Plastic Surgery, Royal Free Hospital, London, United Kingdom, Division of Surgery and Interventional Science, University College London, London, United Kingdom |
Chronic wounds are a considerable health burden with high morbidity and poor rates of healing. Colonisation of chronic wounds by bacteria can be a significant factor in their poor healing rate. These bacteria can develop antibiotic resistance over time and can lead to wound infections, systemic illness, and occasionally amputation. When a large number of micro-organisms colonise wounds, they can lead to biofilm formation, which are self-perpetuating colonies of bacteria closed within an extracellular matrix, which are poorly penetrated by antibiotics. Platelet-rich plasma (PRP) is an autologous blood product rich in growth factors and cytokines that are involved in an inflammatory response. PRP can be injected or applied to a wound as a topical gel, and there is some interest regarding its antimicrobial properties and whether this can improve wound healing. This study aimed to evaluate the in vitro bacteriostatic effect of PRP. PRP was collected from healthy volunteers and processed into two preparations: activated PRP—activated with calcium chloride and ethanol; inactivated PRP. The activity of each preparation against Staphylococcus aureus and Staphylococcus epidermis was evaluated against a control by three experiments: bacterial kill assay to assess planktonic bacterial growth; plate colony assay to assess bacterial colony growth; and colony biofilm assay to assess biofilm growth. Compared with control, both preparations of PRP significantly inhibited growth of planktonic S aureus and S epidermis. Activated PRP reduced planktonic bacterial concentration more than inactivated PRP in both bacteria. Both PRP preparations significantly reduced bacterial colony counts for both bacteria when compared with control; however, there was no difference between the two. There was no difference found between biofilm growth in either PRP against control or against the other preparation. This study demonstrates that PRP does have an inhibitory effect on the growth of common wound pathogens. Activation may be an important factor in increasing the antimicrobial effect of PRP. However, we did not find evidence of an effect against more complex bacterial colonies. © 2021 The Authors. International Wound Journal published by Medicalhelplines.com Inc (3M) and John Wiley & Sons Ltd. |
antimicrobial therapy; chronic wounds; platelet-rich plasma |
alcohol; calcium chloride; antiinfective agent; Article; bacterial count; bacterial growth; bacterial strain; bacteriostatic activity; bacterium colony; biofilm; controlled study; extracellular matrix; in vitro study; nonhuman; Staphylococcus aureus; Staphylococcus epidermidis; thrombocyte activation; thrombocyte rich plasma; human; Staphylococcus infection; wound healing; wound infection; Anti-Bacterial Agents; Humans; Platelet-Rich Plasma; Staphylococcal Infections; Wound Healing; Wound Infection |
John Wiley and Sons Inc |
17424801 |
|
33476481 |
Article |
Q1 |
867 |
5385 |
|
|
|
311 |
Sunardi D., Bardosono S., Basrowi R.W., Wasito E., Vandenplas Y. |
57192075078;21933841000;57024210400;6506940239;57223670656; |
Dietary determinants of anemia in children aged 6–36 months: A cross-sectional study in Indonesia |
2021 |
Nutrients |
13 |
7 |
2397 |
|
|
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109524537&doi=10.3390%2fnu13072397&partnerID=40&md5=2e8ac565ce8b6f3dd3f70a2de509a9ad |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Vrije Universiteit Brussel (VUB), UZ Brussels, KidZ Health Castle, Brussels, 1090, Belgium |
Sunardi, D., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, 10430, Indonesia; Basrowi, R.W., Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Wasito, E., Medical Nutrition for Danone Specialized Nutrition, Yogyakarta, 55165, Indonesia; Vandenplas, Y., Vrije Universiteit Brussel (VUB), UZ Brussels, KidZ Health Castle, Brussels, 1090, Belgium |
Anemia has been acknowledged as worldwide problem, including in Indonesia. This cross-sectional study aims to explore dietary determinants as risk factors for anemia in children aged 6–36 months living in a poor urban area of Jakarta. The study was done in Kampung Melayu sub-district in Jakarta, Indonesia. Data was collected within two weeks in September–October 2020. A structured questionnaire for a 24-h recall and a semi-quantitative Food Frequency Questionnaire (FFQ) were used to collect the dietary intake data, and venous blood was withdrawn to determine the hemoglobin levels. Bivariate chi-square and multiple logistic regression tests were executed to explore the dietary determinant factors for anemia. We recruited 180 subjects. The average hemoglobin concentration was 11.4 ± 1.7 mg/dL; the anemia prevalence was 29.4%. The following variables were significantly associated with higher risk of anemia: no cow’s milk formula consumption, inadequate intake of fats, protein, calcium, vitamin D, iron, zinc, vitamin A, vitamin C, vitamin B6, and vitamin B12. Only cow’s milk formula consumption and zinc intake were revealed as the determinant factors of anemia. In conclusion, the prevalence of anemia was 29.4% among children aged 6–36 months old. Anemia was significantly associated with two dietary determinants as risk factors that are cow’s milk formula consumption and zinc intake. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Anemia; Cow’s milk; Cow’s milk formula; Indonesia; Toddler; Zinc |
biological marker; hemoglobin; zinc; adverse event; age; anemia; artificial milk; blood; bottle feeding; cross-sectional study; diet; female; human; Indonesia; infant; infant nutrition; male; metabolism; nutritional status; pathophysiology; preschool child; prevalence; risk assessment; risk factor; urban health; Age Factors; Anemia; Biomarkers; Bottle Feeding; Child, Preschool; Cross-Sectional Studies; Diet; Diet Surveys; Female; Hemoglobins; Humans; Indonesia; Infant; Infant Formula; Infant Nutritional Physiological Phenomena; Male; Nutritional Status; Prevalence; Risk Assessment; Risk Factors; Urban Health; Zinc |
MDPI AG |
20726643 |
|
34371908 |
Article |
Q1 |
1418 |
2497 |
|
|
|
314 |
Kreshanti P., Putri N.T., Martin V.J., Sukasah C.L. |
36192866200;57192904294;57221635093;57218391534; |
The effectiveness of oral propranolol for infantile hemangioma on the head and neck region: A case series |
2021 |
International Journal of Surgery Case Reports |
84 |
|
106120 |
|
|
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109354279&doi=10.1016%2fj.ijscr.2021.106120&partnerID=40&md5=d7e0ac8c9d5ad4046f2b8c78dc622412 |
Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kreshanti, P., Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Putri, N.T., Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Martin, V.J., Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sukasah, C.L., Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Infantile hemangioma is the most common tumor in infancy, with 60% occurring on the face and neck. A large tumor involving the facial region will cause significant aesthetic and functional impairment and isn't always easy to treat surgically. A non-invasive treatment is needed for this condition. Propranolol has recently been used as a choice of treatment in infantile hemangioma. Presentation of case: We presented two cases of large problematic infantile hemangioma that were successfully managed with oral propranolol. Discussion: Large problematic lesions that ulcerate and bleed often need surgery; however, a substantial defect resulting from surgery is tricky to reconstruct and can cause significant scar. Propranolol is used because of its efficacy and low risk characteristics. Conclusion: Propranolol is an effective treatment to reduce the need of surgical intervention in problematic hemangioma. © 2021 The Authors |
Case report; Infantile hemangioma; Propranolol; Surgery |
eye ointment; gentamicin; propranolol; blood pressure monitoring; capillary hemangioma; case report; cheek; child; clinical article; clinical effectiveness; clinical feature; dermatologist; drug dose increase; drug efficacy; ecchymosis; eye protection; eyelid; female; head and neck disease; heart rate measurement; human; lung function test; male; neoplasm; ophthalmologist; palpation; patient referral; preschool child; risk; Short Survey; skin color; skin ulcer; tumor volume |
Elsevier Ltd |
22102612 |
|
|
Short Survey |
Q3 |
232 |
17549 |
|
|
|
328 |
Sihotang R.C., Alvonico T., Taher A., Birowo P., Rasyid N., Atmoko W. |
57216755881;57216743520;7005269743;6504153311;56245069300;57193125664; |
Premature ejaculation in patients with lower urinary tract symptoms: a systematic review |
2021 |
International Journal of Impotence Research |
33 |
5 |
|
516 |
524 |
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084492871&doi=10.1038%2fs41443-020-0298-5&partnerID=40&md5=243ef2c5fa8e96c70ec2e3eb9ca5b534 |
Faculty of Medicine, Universitas Indonesia, No. 6, Salemba Raya Road, DKI Jakarta, 10430, Indonesia; Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia |
Sihotang, R.C., Faculty of Medicine, Universitas Indonesia, No. 6, Salemba Raya Road, DKI Jakarta, 10430, Indonesia; Alvonico, T., Faculty of Medicine, Universitas Indonesia, No. 6, Salemba Raya Road, DKI Jakarta, 10430, Indonesia; Taher, A., Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia; Birowo, P., Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia; Rasyid, N., Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia; Atmoko, W., Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia |
Lower urinary tract symptoms (LUTS) refer to a group of symptoms related to bladder, prostate, and urethra. LUTS are common in men and the severity increases with age. LUTS are frequently associated with sexual dysfunction, such as premature ejaculation (PE), standing as the most common sexual dysfunction in men. Both LUTS and PE cause distress and dissatisfaction for the patient and his partner. This systematic review aims to determine the relationship between LUTS and PE in men. Two reviewers independently conduct a literature search in five online databases (PubMed, Scopus, Proquest, ClinicalKey, and ScienceDirect). In addition, reviewers also reviewed the reference list of chosen articles to identify additional relevant studies. Twelve articles were included in this systematic review that consists of one cohort study and 11 cross-sectional studies. The total scores of each identified study ranged from “poor” to “good.” The prevalence of PE in LUTS ranged from 12 to 77%. Most of the studies showed a significant relationship between LUTS and PE. PE is more common in older age with the peak prevalence in age of 60–69 years old. There is a possible association between PE and LUTS. Further research using cohort or case-control study design on this topic is needed. © 2020, The Author(s), under exclusive licence to Springer Nature Limited. |
|
age; human; International Prostate Symptom Score; male; outcome assessment; premature ejaculation; prevalence; prostatectomy; Review; systematic review; urinary tract infection; aged; case control study; cohort analysis; complication; cross-sectional study; ejaculation; lower urinary tract symptom; middle aged; premature ejaculation; Aged; Case-Control Studies; Cohort Studies; Cross-Sectional Studies; Ejaculation; Humans; Lower Urinary Tract Symptoms; Male; Middle Aged; Premature Ejaculation |
Springer Nature |
09559930 |
|
32393845 |
Review |
Q2 |
508 |
9947 |
|
|
|
339 |
Agustina R., Wirawan F., Sadariskar A.A., Setianingsing A.A., Nadiya K., Prafiantini E., Asri E.K., Purwanti T.S., Kusyuniati S., Karyadi E., Raut M.K. |
57214141404;57205313463;57210125132;57226321426;57216508166;57193088368;57190772302;57205062492;57205061970;6603080272;57216503454; |
Associations of Knowledge, Attitude, and Practices toward Anemia with Anemia Prevalence and Height-for-Age Z-Score among Indonesian Adolescent Girls |
2021 |
Food and Nutrition Bulletin |
42 |
1_suppl |
|
S92 |
S108 |
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111145577&doi=10.1177%2f03795721211011136&partnerID=40&md5=d0a997eb61ed43eeeaf66ad5f9bb416a |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Study Program, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Nutrition International Country Office, Jakarta, Indonesia; Former Nutrition International Country Office, Jakarta, Indonesia; Nutrition International, Asia Regional Office, New Delhi, India |
Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wirawan, F., Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sadariskar, A.A., Medical Study Program, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Setianingsing, A.A., Medical Study Program, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Nadiya, K., Medical Study Program, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Prafiantini, E., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Asri, E.K., Nutrition International Country Office, Jakarta, Indonesia; Purwanti, T.S., Nutrition International Country Office, Jakarta, Indonesia; Kusyuniati, S., Nutrition International Country Office, Jakarta, Indonesia; Karyadi, E., Former Nutrition International Country Office, Jakarta, Indonesia; Raut, M.K., Nutrition International, Asia Regional Office, New Delhi, India |
Background: Crucial gaps persist in knowledge, attitude, and practice (KAP) of adolescent girls that affect anemia and linear growth failure. Objective: To understand the role of KAP as a risk factor of anemia and linear growth problem in adolescent girls. Methods: We conducted a cross-sectional survey of 335 adolescent girls selected by clustered random sampling. The KAP questionnaire had 18 variables consisting of 9 knowledge, 3 attitude, and 6 practice components. Twelve variables addressed nutrition, dietary diversity, and health environments related to both anemia and stunting. The questionnaire was adapted from the 2014 Food and Agriculture Organization nutrition-related KAP guidelines for anemia. Dietary practice was evaluated from 2-day 24-hour recalls and a semi-quantitative food-frequency questionnaire. Associations between KAP and anemia, and height-for-age z-score (HAZ), were analyzed using multivariate logistic and linear regression models, respectively. Results: The mean hemoglobin (Hb) level was 119.7 g/L, with 44% of the adolescent girls being anemic (Hb < 120 g/L) and mean height was 151.0 cm with 25% being stunted (HAZ < −2 standard deviation [SD]). The median KAP score was 7 and ranged from 3 to 10. Low to moderate KAP scores were not significantly associated with being anemic (adjusted odds ratio [AOR] = 1.26; P =.43), however 1-point KAP score increment was associated with an increase of HAZ by 0.037 SD (P =.012). Conclusions: The KAP related to diet and healthy environments was not associated with anemia prevalence, but was positively associated with increased HAZ among adolescent girls. Strategy to reduce anemia risk in this population should combine KAP improvement with other known effective nutrition interventions. © The Author(s) 2021. |
adolescent girls; anemia; hemoglobin; knowledge-attitude-practice; linear growth |
adolescence; anemia; attitudinal survey; disease prevalence; hemoglobin; risk factor |
SAGE Publications Inc. |
03795721 |
|
34282657 |
Article |
Q1 |
649 |
7743 |
|
|
|
349 |
Shukla A., Shreshtha A., Mukund A., Bihari C., Eapen C.E., Han G., Deshmukh H., Cua I.H.Y., Lesmana C.R.A., Al Meshtab M., Kage M., Chaiteeraki R., Treeprasertsuk S., Giri S., Punamiya S., Paradis V., Qi X., Sugawara Y., Abbas Z., Sarin S.K. |
36652088000;57225888142;15071187800;49860931800;7003684081;24741087200;7003527959;7801457234;8977683000;57225918379;57225886245;57225920095;57077082800;57221051314;23670642900;57195572516;35339923000;57197741618;35572268700;57220191468; |
Budd-Chiari syndrome: consensus guidance of the Asian Pacific Association for the study of the liver (APASL) |
2021 |
Hepatology International |
15 |
3 |
|
531 |
567 |
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109622410&doi=10.1007%2fs12072-021-10189-4&partnerID=40&md5=727d2318980fa73306867439390cc762 |
Department of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Alka Hospital, Kathmandu, Nepal; Institute of Liver and Biliary Sciences, New Delhi, India; Christian Medical College, Vellore, India; Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, China; Dean and Head of Radiology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Institute of Digestive and Liver Diseases, St Lukes Medical Center, Global City, Philippines; Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia; Digestive Disease & GI Oncology Center, Medistra Hospital, Jakarta, Indonesia; Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh; Center for Innovative Cancer Therapy, Kurume University Research, 67 Asahi-machi, Kurume, 830-0011, Japan; Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Vascular and Interventional Radiology, Tan Tock Seng Hospital, Singapore, Singapore; Dpt dAnatomie Pathologique, Hôpital Beaujon, 100 bd du Gal Leclerc, Clichy, 92110, France; General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), No. 83 Wenhua Road, Shenyang, China; Department of Transplantation and Pediatric Surgery, Kumamoto University, Kumamoto, Japan; Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Karachi, Pakistan |
Shukla, A., Department of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Shreshtha, A., Alka Hospital, Kathmandu, Nepal; Mukund, A., Institute of Liver and Biliary Sciences, New Delhi, India; Bihari, C., Institute of Liver and Biliary Sciences, New Delhi, India; Eapen, C.E., Christian Medical College, Vellore, India; Han, G., Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, China; Deshmukh, H., Dean and Head of Radiology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Cua, I.H.Y., Institute of Digestive and Liver Diseases, St Lukes Medical Center, Global City, Philippines; Lesmana, C.R.A., Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia, Digestive Disease & GI Oncology Center, Medistra Hospital, Jakarta, Indonesia; Al Meshtab, M., Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, Center for Innovative Cancer Therapy, Kurume University Research, 67 Asahi-machi, Kurume, 830-0011, Japan; Kage, M., Department of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Chaiteeraki, R., Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Treeprasertsuk, S., Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Giri, S., Department of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Punamiya, S., Vascular and Interventional Radiology, Tan Tock Seng Hospital, Singapore, Singapore; Paradis, V., Dpt dAnatomie Pathologique, Hôpital Beaujon, 100 bd du Gal Leclerc, Clichy, 92110, France; Qi, X., General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), No. 83 Wenhua Road, Shenyang, China; Sugawara, Y., Department of Transplantation and Pediatric Surgery, Kumamoto University, Kumamoto, Japan; Abbas, Z., Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Karachi, Pakistan; Sarin, S.K., Institute of Liver and Biliary Sciences, New Delhi, India |
Budd Chiari syndrome (BCS) is a diverse disease with regard to the site of obstruction, the predisposing thrombophilic disorders and clinical presentation across the Asia-Pacific region. The hepatic vein ostial stenosis and short segment thrombosis are common in some parts of Asia-Pacific region, while membranous obstruction of the vena cava is common in some and complete thrombosis of hepatic veins in others. Prevalence of myeloproliferative neoplasms and other thrombophilic disorders in BCS varies from region to region and with different sites of obstruction. This heterogeneity also raises several issues and dilemmas in evaluation and approach to management of a patient with BCS. The opportunity to recanalize hepatic vein in patients with hepatic vein ostial stenosis or inferior vena cava stenting or pasty among those membranous obstruction of the vena cava is a unique opportunity in the Asia–Pacific region to restore hepatic outflow closely mimicking physiology. In order to address these issues arising out of the diversity as well as the unique features in the region, the Asia Pacific Association for Study of Liver has formulated these guidelines for clinicians. © 2021, Asian Pacific Association for the Study of the Liver. |
Ascites; Budd Chiari syndrome; Hepatic vein stenting; Hepatocellular carcinoma; HVOTO; Liver biopsy; Liver transplant; MOVC; Portal hypertension; TIPS |
calreticulin; low molecular weight heparin; acute liver failure; acute on chronic liver failure; angioplasty; anticoagulant therapy; Article; Asia; blood clot lysis; blood clotting; Budd Chiari syndrome; cancer chemotherapy; chemoembolization; clinical feature; computer assisted tomography; Doppler flowmetry; female fertility; follow up; groups by age; hepatocellular adenoma; human; hyperhomocysteinemia; incidence; inferior cava vein; liver adenoma; liver cell carcinoma; liver nodule; liver transplantation; liver vein; nodular hyperplasia; nuclear magnetic resonance imaging; pathogenesis; postoperative complication; practice guideline; pregnancy; preoperative evaluation; prognosis; recanalization; risk factor; stent thrombosis; survival factor; thrombophilia; transjugular intrahepatic port |
Springer |
19360533 |
|
34240318 |
Article |
Q2 |
1304 |
2874 |
|
|
|
378 |
Mori Y., Sato H., Kumazawa T., Mayang Permata T.B., Yoshimoto Y., Murata K., Noda S.-E., Kaminuma T., Ando K., Oike T., Okonogi N., Okada K., Kakoti S., Suzuki K., Ikota H., Yokoo H., Nakano T., Ohno T., Shibata A. |
57210846989;55697961900;57210432294;57197808751;36453407100;36103294900;14621772700;23994005700;55641963900;36453136000;36453127400;57222984111;57197814645;57376271900;57214213081;55588986400;35353843800;35395665700;8323572900; |
Analysis of radiotherapy-induced alteration of CD8+ T cells and PD-L1 expression in patients with uterine cervical squamous cell carcinoma |
2021 |
Oncology Letters |
21 |
6 |
446 |
|
|
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104336493&doi=10.3892%2fol.2021.12707&partnerID=40&md5=a047e0e92118f6cb0de5b48cfc613e96 |
Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Department of Radiotherapy, Saitama Cancer Center, Ina, Saitama, 362-0806, Japan; Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Department of Radiation Oncology, Fukushima Medical University, Fukushima, 960-1247, Japan; Department of Radiation Oncology, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Hidaka, Saitama, 350-1298, Japan; National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan; Signal Transduction Program, Gunma University Initiative for Advanced Research, Gunma University, Maebashi, Gunma, 371-8511, Japan; Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan; Clinical Department of Pathology, Gunma University Hospital, Maebashi, Gunma, 371-8511, Japan; Department of Human Pathology, Gunma University, Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan |
Mori, Y., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan, Department of Radiotherapy, Saitama Cancer Center, Ina, Saitama, 362-0806, Japan; Sato, H., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Kumazawa, T., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Mayang Permata, T.B., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Yoshimoto, Y., Department of Radiation Oncology, Fukushima Medical University, Fukushima, 960-1247, Japan; Murata, K., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Noda, S.-E., Department of Radiation Oncology, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Hidaka, Saitama, 350-1298, Japan; Kaminuma, T., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Ando, K., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Oike, T., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Okonogi, N., National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan; Okada, K., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Kakoti, S., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan, Signal Transduction Program, Gunma University Initiative for Advanced Research, Gunma University, Maebashi, Gunma, 371-8511, Japan; Suzuki, K., Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, 852-8523, Japan; Ikota, H., Clinical Department of Pathology, Gunma University Hospital, Maebashi, Gunma, 371-8511, Japan; Yokoo, H., Department of Human Pathology, Gunma University, Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan; Nakano, T., National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan; Ohno, T., Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma, 371-8511, Japan; Shibata, A., Signal Transduction Program, Gunma University Initiative for Advanced Research, Gunma University, Maebashi, Gunma, 371-8511, Japan |
Radiotherapy induces an immune response in the cancer microenvironment that may influence clinical outcome. The present study aimed to analyse the alteration of CD8+ T-cell infiltration and programmed death-ligand 1 (PD-L1) expression following radiotherapy in clinical samples from patients with uterine cervical squamous cell carcinoma. Additionally, the current study sought to analyse the associa- tion between these immune responses and clinical outcomes. A total of 75 patients who received either definitive chemoradio- therapy or radiotherapy were retrospectively analyzed. CD8+ T-cell infiltration and PD-L1 expression were determined by immunohistochemistry using biopsy specimens before radio- therapy (pre-RT) and after 10 Gy radiotherapy (post-10 Gy). The PD-L1+ rate was significantly increased from 5% (4/75) pre-RT to 52% (39/75) post-10 Gy (P<0.01). Despite this increase in the PD-L1+ rate post-10 Gy, there was no significant association between both pre-RT and post-10 Gy and overall survival (OS), locoregional control (LC) and progression-free survival (PFS). On the other hand, the CD8+ T-cell infiltration density was significantly decreased for all patients (median, 23.1% pre-RT vs. 16.9% post-10 Gy; P=0.038); however, this tended to increase in patients treated with radiotherapy alone (median, 17.7% pre-RT vs. 24.0% post-10 Gy; P=0.400). Notably, patients with high CD8+ T-cell infiltration either pre-RT or post-10 Gy exhibited positive associations with OS, LC and PFS. Thus, the present analysis suggested that CD8+ T-cell infiltration may be a prognostic biomarker for patients with cervical cancer receiving radiotherapy. Furthermore, immune checkpoint inhibitors may be effective in patients who have received radiotherapy, since radiotherapy upregu- lated PD-L1 expression in cervical cancer specimens. © 2021 Spandidos Publications. All rights reserved. |
CD8+ T cell; Cervical cancer; Immune modulation; Programmed death-ligand 1; Radiotherapy; Tumor microenvironment |
alcohol; biological marker; biotin; cisplatin; citric acid; diaminobenzidine; edetic acid; formaldehyde; hydrogen peroxide; immune checkpoint inhibitor; paraffin; peroxidase; platinum; programmed death 1 ligand 1; streptavidin; adult; aged; antigen retrieval; Article; biopsy; brachytherapy; cancer radiotherapy; cancer staging; CD8+ T lymphocyte; cell density; cell infiltration; chemoradiotherapy; controlled study; diagnostic test accuracy study; down regulation; female; follow up; human; human tissue; immune response; immunohistochemistry; irradiation; lymph node metastasis; major clinical study; microscopy; overall survival; paraffin embedding; progression free survival; protein expression; receiver operating characteristic; retrospective study; room temperature; tumor associated leukocyt |
Spandidos Publications |
17921074 |
|
|
Article |
Q3 |
766 |
6367 |
|
|
|
401 |
Safari D., Gultom S.M., Tafroji W., Azzahidah A., Soesanti F., Khoeri M.M., Prayitno A., Pimenta F.C., da Gloria Carvalho M., Uiterwaal C.S.P.M., Putri N.D. |
23493586700;57223995277;57118271600;57223997121;37068080600;55994827400;57193342301;6603696480;55189494500;7006033434;57200573842; |
Prevalence, serotype and antibiotic susceptibility of Group B Streptococcus isolated from pregnant women in Jakarta, Indonesia |
2021 |
PLoS ONE |
16 |
5 May |
e0252328 |
|
|
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106668508&doi=10.1371%2fjournal.pone.0252328&partnerID=40&md5=d5ae48dcce9738619d131a8193789686 |
Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Aix-Marseille University, Marseille, France; Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Julius Center for Health Sciences and Primary Care, Julius Global Health, University Medical Center, Utrecht, Netherlands |
Safari, D., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Gultom, S.M., Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Tafroji, W., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Azzahidah, A., Aix-Marseille University, Marseille, France; Soesanti, F., Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Khoeri, M.M., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Prayitno, A., Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pimenta, F.C., Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; da Gloria Carvalho, M., Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Uiterwaal, C.S.P.M., Julius Center for Health Sciences and Primary Care, Julius Global Health, University Medical Center, Utrecht, Netherlands; Putri, N.D., Faculty of Medicine, Department of Child Health, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Group B Streptococcus (GBS) is a bacterial pathogen which is a leading cause of neonatal infection. Currently, there are limited GBS data available from the Indonesian population. In this study, GBS colonization, serotype distribution and antimicrobial susceptibility profile of isolates were investigated among pregnant women in Jakarta, Indonesia. Demographics data, clinical characteristics and vaginal swabs were collected from 177 pregnant women (mean aged: 28.7 years old) at 29–40 weeks of gestation. Bacterial culture identification tests and latex agglutination were performed for GBS. Serotyping was done by conventional multiplex PCR and antibiotic susceptibility testing by broth microdilution. GBS colonization was found in 53 (30%) pregnant women. Serotype II was the most common serotype (30%) followed by serotype III (23%), Ia and IV (13% each), VI (8%), Ib and V (6% each), and one non-typeable strain. All isolates were susceptible to vancomycin, penicillin, ampicillin, cefotaxime, daptomycin and linezolid. The majority of GBS were resistant to tetracycline (89%) followed by clindamycin (21%), erythromycin (19%), and levofloxacin (6%). The serotype III was more resistant to erythromycin, clindamycin, and levofloxacin and these isolates were more likely to be multidrug resistant (6 out of 10) compared to other serotypes. This report provides demographics of GBS colonization and isolate characterization in pregnant women in Indonesia. The results may facilitate preventive strategies to reduce neonatal GBS infection and improve its treatment. Copyright: This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. |
|
ampicillin; cefotaxime; cefoxitin; ceftizoxime; ciprofloxacin; clindamycin; daptomycin; erythromycin; levofloxacin; linezolid; penicillin derivative; tetracycline; vancomycin; adolescent; adult; antibiotic resistance; antibiotic sensitivity; Article; bacterial colonization; bacterium culture; bacterium identification; bacterium isolate; broth dilution; controlled study; female; gestation period; group B streptococcal infection; human; Indonesia; latex agglutination test; major clinical study; multidrug resistance; multiplex polymerase chain reaction; nonhuman; pregnancy; prevalence; serotype; Streptococcus agalactiae; vagina smear; antibiotic resistance; isolation and purification; pregnancy; pregnancy complication; Streptococcus agalactiae; Streptococcus infection; young adult; Adolescent |
Public Library of Science |
19326203 |
|
34043711 |
Article |
Q1 |
990 |
4434 |
|
|
|
419 |
Iwai M., Tulafu M., Togo S., Kawaji H., Kadoya K., Namba Y., Jin J., Watanabe J., Okabe T., Hidayat M., Sumiyoshi I., Itoh M., Koyama Y., Ito Y., Orimo A., Takamochi K., Oh S., Suzuki K., Hayashizaki Y., Yoshida K., Takahashi K. |
56357096800;55818028100;9533914900;57196621148;57193562606;55413965500;57221345975;57202019639;57208252941;56435992700;57202003876;57218355452;57202921569;57225926629;56922531400;57070836300;56922435100;57221017119;57216108710;55725231300;57226207751; |
Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin α11 expression |
2021 |
Molecular Oncology |
15 |
5 |
|
1507 |
1527 |
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103164588&doi=10.1002%2f1878-0261.12937&partnerID=40&md5=b2e053e6ecbd024c8cbcf42081179238 |
Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Leading Center for the Development and Research of Cancer Medicine, Juntendo University, Tokyo, Japan; Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Japan; Preventive Medicine and Applied Genomics Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Department of Respiratory and Critical Care Medicine, National Center of Gerontology, Beijing Hospital, China; Department of Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine, Jakarta, Indonesia; Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan; Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Japan; Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Faculty of Biology-Oriented Science and Technology, Kindai University, Wakayama, Japan |
Iwai, M., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Tulafu, M., Leading Center for the Development and Research of Cancer Medicine, Juntendo University, Tokyo, Japan; Togo, S., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Kawaji, H., Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Japan, Preventive Medicine and Applied Genomics Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Kadoya, K., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Namba, Y., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Jin, J., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan, Department of Respiratory and Critical Care Medicine, National Center of Gerontology, Beijing Hospital, China; Watanabe, J., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Okabe, T., Leading Center for the Development and Research of Cancer Medicine, Juntendo University, Tokyo, Japan; Hidayat, M., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan, Department of Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine, Jakarta, Indonesia; Sumiyoshi, I., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Itoh, M., RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Koyama, Y., Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan, Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Japan; Ito, Y., Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan; Orimo, A., Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan; Takamochi, K., Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Oh, S., Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Suzuki, K., Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Hayashizaki, Y., RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Yoshida, K., Faculty of Biology-Oriented Science and Technology, Kindai University, Wakayama, Japan; Takahashi, K., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan |
Cancer-associated fibroblasts (CAFs) regulate cancer progression through the modulation of extracellular matrix (ECM) and cancer cell adhesion. While undergoing a series of phenotypic changes, CAFs control cancer–stroma interactions through integrin receptor signaling. Here, we isolated CAFs from patients with non-small-cell lung cancer (NSCLC) and examined their gene expression profiles. We identified collagen type XI α1 (COL11A1), integrin α11 (ITGA11), and the ITGA11 major ligand collagen type I α1 (COL1A1) among the 390 genes that were significantly enriched in NSCLC-associated CAFs. Increased ITGA11 expression in cancer stroma was correlated with a poor clinical outcome in patients with NSCLC. Increased expression of fibronectin and collagen type I induced ITGA11 expression in CAFs. The cellular migration of CAFs toward collagen type I and fibronectin was promoted via ERK1/2 signaling, independently of the fibronectin receptor integrin α5β1. Additionally, ERK1/2 signaling induced ITGA11 and COL11A1 expression in cancer stroma. We, therefore, propose that targeting ITGA11 and COL11A1 expressing CAFs to block cancer–stroma interactions may serve as a novel, promising anti-tumor strategy. © 2021 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. |
cancer; cancer-associated fibroblast; collagen type I; collagen type XI α1; integrin alpha-11; non-small-cell lung cancer; stroma interaction; transforming growth factor beta |
alpha11 integrin; collagen type 1; collagen type 1 alpha1; collagen type 11; collagen type 11 alpha1; fibronectin; fibronectin receptor; integrin; mitogen activated protein kinase 3; retrovirus vector; small interfering RNA; transforming growth factor beta1; unclassified drug; very late activation antigen 5; adult; aged; Article; cancer associated fibroblast; cancer recurrence; cell interaction; cell migration; chemotaxis; clinical article; clinical outcome; controlled study; DNA modification; enzyme linked immunosorbent assay; female; gene expression profiling; human; human cell; human tissue; immunohistochemistry; in vitro study; lung adenocarcinoma; lung fibroblast; lung parenchyma; male; non small cell lung cancer; priority journal; protein expression; protein expression level; protein |
John Wiley and Sons Ltd |
15747891 |
|
33682233 |
Article |
Q1 |
2332 |
1019 |
|
|
|
427 |
Setiati S., Soejono C.H., Harimurti K., Dwimartutie N., Aryana I.G.P.S., Sunarti S., Budiningsih F., Mulyana R., Dwipa L., Sudarso A., Rensa R., Istanti R., Azwar M.K., Marsigit J. |
14325991900;24472241900;23473513200;37067234900;37062993600;57215563311;56483278600;57203246879;55321762700;57223602321;6504343309;23496653300;57202798959;57218912589; |
Frailty and Its Associated Risk Factors: First Phase Analysis of Multicentre Indonesia Longitudinal Aging Study |
2021 |
Frontiers in Medicine |
8 |
|
658580 |
|
|
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105939470&doi=10.3389%2ffmed.2021.658580&partnerID=40&md5=b2d32afefa94ab6754eec53482b82d31 |
Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Udayana, Bali, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Solo, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Hasanuddin, Makasar, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Atma Jaya, Jakarta, Indonesia |
Setiati, S., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia, Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Soejono, C.H., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Harimurti, K., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia, Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Dwimartutie, N., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Aryana, I.G.P.S., Department of Internal Medicine, Faculty of Medicine, Universitas Udayana, Bali, Indonesia; Sunarti, S., Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Budiningsih, F., Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Solo, Indonesia; Mulyana, R., Department of Internal Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Dwipa, L., Department of Internal Medicine, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Sudarso, A., Department of Internal Medicine, Faculty of Medicine, Universitas Hasanuddin, Makasar, Indonesia; Rensa, R., Department of Internal Medicine, Faculty of Medicine, Universitas Atma Jaya, Jakarta, Indonesia; Istanti, R., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Azwar, M.K., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Marsigit, J., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background: National long-term care development requires updated epidemiological data related to frailty. We aimed to find the prevalence of frailty and its associated factors among Indonesian elderly. Methods: We conducted first-phase cross-sectional analysis of Indonesia Longitudinal Aging Study (INALAS) data collected from community-dwelling outpatients aged 60 years and older without acute illness in nine geriatric service care centres. Descriptive, bivariate and multivariate analyses were conducted. Results: Among 908 elderly in this study, 15.10% were robust, 66.20% were pre-frail, and 18.70% were frail. Functional dependence was associated with frailty among Indonesian elderly (OR 5.97, 95% CI 4.04–8.80). Being depressed and at risk for malnutrition were also associated with frailty with OR 2.54, 95% CI 1.56–4.12, and OR 2.56, 95% CI 1.68–3.90, respectively. Prior history of fall (OR 1.77, 95% CI 1.16–2.72) and hospitalization (OR 1.46, 95% CI 0.97–2.20) in the previous 12 months were associated with frailty. There is also significant association between poly pharmacy and frailty (OR 2.42, 95% CI 1.50–3.91). Conclusion: Approximately one in five Indonesian community-dwelling elderly was frail. Frailty is associated with functional dependence, being at risk for malnutrition or being malnourished, depression, history of fall, history of hospitalization, and poly pharmacy. There may be bidirectional relationships between the risk factors and frailty. The development of long-term care in Indonesia should be considered, without forcing the elderly who need it. © Copyright © 2021 Setiati, Soejono, Harimurti, Dwimartutie, Aryana, Sunarti, Budiningsih, Mulyana, Dwipa, Sudarso, Rensa, Istanti, Azwar and Marsigit. |
community-dwelling elderly; frailty; Indonesia; long-term care; prevalence; risk factors |
adult; aged; aging; Article; community dwelling person; cross-sectional study; depression; falling; female; frailty; functional status; high risk population; hospitalization; human; Indonesian; longitudinal study; major clinical study; male; malnutrition; medical history; outpatient; polypharmacy; prevalence; risk factor |
Frontiers Media S.A. |
2296858X |
|
|
Article |
Q1 |
1388 |
2608 |
|
|
