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Pratiwi R.Y., Elya B., Setiawan H., Solawati A., Rosmalena |
57416375400;14014224500;55292870100;57415864600;56891769500; |
Alterations in Body Weight, Blood Glucose Levels, and Lipid Profiles in High-Fat Diet-Low Dose Streptozotocin-Induced Diabetic Rats |
2021 |
Pharmacognosy Journal |
13 |
6 |
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1562 |
1567 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122997406&doi=10.5530%2fpj.2021.13.199&partnerID=40&md5=81ed302e467e0f8fcf593bb03fe63dd1 |
Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Pratiwi, R.Y., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Elya, B., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Setiawan, H., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Solawati, A., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Rosmalena, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Introduction: New preventive and therapeutic strategies to treat Type 2 diabetes (T2D) continue to be pursued, the complexity of this disease makes it imperative to establish preclinical animal models which must provide accurate similarities to the pathogenesis of diabetes in humans. Making a diabetic animal model using rats with high-fat diet (HFD)-streptozotocin (STZ) induction is popular because it is relatively low cost and simple. Objectives: This study aims to analyse the changes in body weight, blood glucose, and lipid profiles that occur in diabetic rat models created by induction of HFD in combination with lowdose STZ. Methods: This study used forty male Sprague-Dawley rats (200-240 g). After the adaptation period, thirty rats were fed with HFD for 28 days (DM group), while the other ten rats continued to be fed with standard feed (NC group). After then, diabetes was induced to the DM group by low-dose STZ (35 mg/kg BW). The body weight of the rats was measured before and after diet manipulation periods. Blood samples were taken before and after STZ induction to determine lipid profiles and blood glucose levels. Results: During the diet manipulation period, the HFD group experienced a significantly greater weight gain, higher blood glucose levels, and cholesterol (TC) levels. After STZ injection, rats' blood glucose levels, TC, and triglycerides significantly increased. Conclusion: HFD feeding combined with a low-dose STZ effectively work to mimic specific condition that is similar to T2D, and the stability of the experimental animal conditions remains constant for up to 6 weeks. © 2021 Phcogj.Com. |
Diabetes; Diabetic animal model; High-fat diet; Insulin resistance; Low-dose streptozotocin; Stable diabetes type 2 profile |
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Wardatun S., Harahap Y., Sutandyo N., Mun'im A. |
56656540800;16480400300;26028099200;57200562136; |
Analyzing of Urine 3-Hidroxy Propil Mercapturic Acid on Cyclophosphamide Induced Rat to Determine Ameliorating Effect of Leucaena leucocephala (Lam.) de Wit Seed Extract |
2021 |
Pharmacognosy Journal |
13 |
6 |
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1549 |
1556 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122983266&doi=10.5530%2fpj.2021.13.197&partnerID=40&md5=800384ddb85b8305ebff1ba328165147 |
Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Program Study of Pharmacy, Universitas Pakuan, Bogor, Indonesia; Faculty of Pharmacy, Republic of Indonesia Defense University, Bogor, Indonesia; Dharmais, Cancer Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Depok, Indonesia |
Wardatun, S., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia, Program Study of Pharmacy, Universitas Pakuan, Bogor, Indonesia; Harahap, Y., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia, Faculty of Pharmacy, Republic of Indonesia Defense University, Bogor, Indonesia; Sutandyo, N., Dharmais, Cancer Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Mun'im, A., Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia |
Background: A 70% ethanolic extract of Leucaena leucocephala (Lam.) de Wit seeds contain a certain amount of sulfhydryl active compounds and potential for ameliorated cyclophosphamide side effects. Objective: The aim of this study was to analyze of urine 3-hidroxy propil mercapturic acid (3-HPMA) in a rat model for cyclophosphamide-induced hemorrhagic cystitis to determine the effect of Leucaena leucocephala (Lam.) de Wit seeds extract. Materials and methods: The levels of urine 3-hidroxy propil mercapturic acid was measured using LCMS/MS. Urine preparation was carried out by dilution (1:5) with mobile phase and contained a deuteurated internal standard. The LC separation was performed using a C18 column (1.7 μm; 2.1 mm × 100 mm). The mobile phase consisted of formic acid (0.1%) and formic acid (0.1%) in acetonitrile (90:10 v/v), as a starting gradient at flow rate of 0.2 ml/min with total run 7 min. Results: The lower limit of quantification was 40 ng/ml and the linear extended to 20,000 ng/ml. The method has been successfully to be applied in determined of rat urine 3-HPMA. The results showed that the 70% ethanolic extract of seeds can increased the amount of 3-HPMA in rat urine. Conclusion: The 70% ethanolic extract of seeds displayed a potential ameliorating effect against cyclophosphamide side effects. © 2021 Phcogj.Com. |
3-Hidroxypropil mercapturic acid; Cyclophosphamide; Leucaena leucocephala (Lam.) de Wit; Urine |
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Teja Y., Helianthi D.R., Nareswari I. |
57325017200;57194729482;57194336586; |
The Role of Medical Acupuncture Therapy in Alzheimer's Disease |
2021 |
Medical Acupuncture |
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402 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122562853&doi=10.1089%2facu.2021.0014&partnerID=40&md5=a4d04ed95475b2b444ea8f76846422fb |
Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia; Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Teja, Y., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Helianthi, D.R., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nareswari, I., Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, Indonesia, Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory deficits and other cognitive disorders, which can be accompanied by personality changes. Long-term use of medications available to treat AD today have a variety of side-effects. Acupuncture, as a nonpharmacologic therapeutic modality providing stimulation at acupuncture points, using filiform needles, has been widely tested and used to manage of AD and can be a therapeutic option, considering its effectiveness and lack of side-effects. Methods: This literature review examines the role of acupuncture in AD treatment. Results: Acupuncture can ameliorate AD symptoms through decreasing amyloid-β protein, reducing neuroinflammation, enhancing the antioxidant system, improving neurogenesis, enhancing prosurvival protein, reducing proapoptotic protein, and regulating brain energy metabolism. Conclusions: According to various research findings, acupuncture may be a therapeutic choice for addressing AD that avoids the long-term side-effects caused by medical therapy. © 2021, Mary Ann Liebert, Inc., publishers. |
Acupuncture; Alzheimer's disease; Amyloid-β (Aβ) plaques; Neurofibrillary tangles; τ-protein |
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Mary Ann Liebert Inc. |
19336586 |
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35 |
Dwijayanti A., Fitrianto A.I., Boediono A., Setiati S., Suyatna F.D. |
55743787900;57377401300;9040094200;14325991900;56039633100; |
Mesenchymal stem cells administration in aged male rats increases testosterone and lower TNF-α levels |
2021 |
International Medical Journal |
28 |
6 |
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601 |
603 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121461058&partnerID=40&md5=bbf2100ed3003ab64dcb298ba7d9f029 |
Doctoral Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Physiology, and Pharmacology, Faculty of Veterinary Medicine, Bogor Agricultural University, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Dwijayanti, A., Doctoral Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fitrianto, A.I., Department of Anatomy, Physiology, and Pharmacology, Faculty of Veterinary Medicine, Bogor Agricultural University, Indonesia; Boediono, A., Department of Anatomy, Physiology, and Pharmacology, Faculty of Veterinary Medicine, Bogor Agricultural University, Indonesia; Setiati, S., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Suyatna, F.D., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Treatment for sex hormone depletion along with chronic inflammation would be beneficial for aging males. Mesenchymal stem cells (MSC) are known for their immunomodulatory activities and differentiation ability in regenerative medicine. Whether MSC could influence both testosterone and pro-inflammatory marker in aging males is uncertain. This study aimed to explore the effects of human umbilical mesenchymal stem cell (hUCMSC) on testosterone, tumor necrosis factor-alpha (TNF-α), and creatinine levels in aged rats. Methods: The hUCMSC was administered to aged male Sprague-Dawley rats (24 months old). After four injections of 1 mil-lion per kg body weight in 3-month intervals, the rats were sacrificed, and serum was collected for biochemical examinations. Results: The hUCMSC administrations increased the testosterone level almost three-fold and decreased the TNF-α level. Moreover, the high testosterone level was strongly correlated with low TNF-α level (p = 0.013; r =-0.863) in aged male rats. These results were following our previous report, which showed that the hUCMSC increased the number of Leydig cells. Serum creatinine levels in the treatment group were slightly increased but were still within the normal limit. Conclusion: The hUCMSC treatment in aged male rats tends to increase testosterone levels and lower TNF-α levels. © 2021 Japan University of Health Sciences & Japan International Cultural Exchange Foundation. |
Aging; Mesenchymal stem cell; Testosterone; TNF-α |
creatinine; sex hormone; testosterone; tumor necrosis factor; aged; aging; animal cell; animal experiment; animal model; animal tissue; Article; body weight; controlled study; creatinine blood level; creatinine clearance; female; gene expression; Leydig cell; male; mesenchymal stem cell; nonhuman; protein expression; rat; regenerative medicine; Sprague Dawley rat; testosterone blood level |
Japan International Cultural Exchange Foundation |
13412051 |
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Q4 |
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20490 |
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41 |
Kusmardi K., Situmorang N.Y., Zuraidah E., Estuningtyas A., Tedjo A. |
56966625300;57357530500;57357911500;55650360200;57189320451; |
The effect of mahkota dewa (Phaleria macrocarpa) leaf extract on the Mucin 1 expression in mice colonic epithelial cells induced by dextran sodium sulfate (DSS) |
2021 |
Pharmacognosy Journal |
13 |
6 |
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1509 |
1515 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120333886&doi=10.5530%2fPJ.2021.13.181&partnerID=40&md5=668714fd6caa4dce8362e17d7e54ca12 |
Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Center, Indonesia Medical Education and Resesarch Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Human Cancer Research Center, IMERI, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kusmardi, K., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Center, Indonesia Medical Education and Resesarch Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia, Human Cancer Research Center, IMERI, Universitas Indonesia, Jakarta, Indonesia; Situmorang, N.Y., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Zuraidah, E., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Estuningtyas, A., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tedjo, A., Drug Development Research Center, Indonesia Medical Education and Resesarch Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Inflammatory bowel disease is a chronic inflammation caused by the malignant inflammation response and if not treated, could lead to colorectal cancer. One of the researched treatment is mahkota dewa (Phaleria macrocarpa) leaf extract that has flavonoid compound known to reduce inflammation. This study was aimed to prove that mahkota dewa leaf extract could reduce inflammation of mice colon induced with dextran sodium sulfate (DSS) and observe MUC1 expression from colon epithelial crypt of Lieberkuhn. Methods: This was a laboratory experiment using biological material (paraffin block) taken from 28 mice and divided into 5 groups: normal, aspirin, low and high dose mahkota dewa, and negative control. They were processed into immunohistochemistry and stained microscopic slides. Afterwards, they were observed with 400x magnification and 5 field-of-view of mice colon crypt of lieberkuhn. Then MUC1 expression was counted using ImageJ to obtain mean immunohistochemistry score and analyzed with SPSS. Results: There were significant reduction of MUC1 expressions from normal, aspirin, and high dose mahkota dewa groups compared to the negative control group. The result shown MUC1 expression from high dose mahkota dewa (M=149.90,SD=3.81) and aspirin (M=158.92,SD=5.28) were closer to normal group (M=148.02,SD=5.28). There were no significant results between negative (M=175.39,SD=14.30) and low dose mahkota dewa group (M=149.90,SD=5.02). Conclusion: There was a reduction of MUC1 expression in DSS-induced mice colonic epithelial cells for high dose mahkota dewa group. This shown that high dosage mahkota dewa leaf extract could reduce inflammation like aspirin. © 2021 Phcogj.Com. |
Anti-inflammatory agent; Colon epithelial cell; Inflammatory bowel disease; Mahkota dewa (Phaleria macrocarpa); MUC 1 expression |
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Rusdi N.K., Yuliana W.L., Purwaningsih E.H., Hestiantoro A., Kusmardi K. |
57211475250;57358166800;57186723500;8743255100;56966625300; |
Subchronic toxicity of lunasin targeted extract (ET-Lun) from soybean seed (Glycine max (L.) Merr.): Perspective from liver histopathology, SGOT, and SGPT levels in Sprague Dawley rats |
2021 |
Pharmacognosy Journal |
13 |
6 |
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1384 |
1388 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120333876&doi=10.5530%2fPJ.2021.13.175&partnerID=40&md5=05cdb4c0d35834a5b3b9ce79bf4c1e56 |
Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, Indonesia; Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia; Department Obstetrics and Gynaecology, School of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Human Cancer Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia |
Rusdi, N.K., Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, Indonesia; Yuliana, W.L., Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. DR. Hamka, Jakarta, Indonesia; Purwaningsih, E.H., Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia; Hestiantoro, A., Department Obstetrics and Gynaecology, School of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kusmardi, K., Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia, Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Human Cancer Research Cluster, Indonesian Medical Education and Reseach Institute, Universitas INDONESIA, Indonesia |
Background: Lunasin Targeted Extract (ET-Lun) has a pharmacology effect in inhibiting inflammation by decreasing COX-2 and iNOS expression. ET-Lun could increase apoptosis and decrease dysplasia (p > 0,05). In addition, ET-Lun could decrease EGFR expression in breast cancer rats. The acute toxicity showed ET-Lun has LD50 more than 5000 mg/kg BW and was practically non-toxic. Objective: this study aimed to determine the subchronic toxicity of ET-Lun. Methods: Male and female Sprague Dawley rats (n=40) were divided into 4 groups, the control group and treatment group ET-Lun dose of 250 mg/Kg BW, 500 mg/kg BW, and 750 mg/kg BW. The ET-Lun was administered for 90 days. On the 91st day, the animals were dissected and examined for SGOT-SGPT levels, liver histopathology, and diameter of the central vein. Results: The SGOT-SGPT levels showed no significant difference between the treatment group and the control group (p > 0.05). On microscopic observation, there was no change or damage to the liver of rats in each group. The diameter of the central vein of the rat liver shows no significant difference between the control and treatment groups. Conclusion: The ET-Lun does not produce adverse effects in liver rats after subchronic treatment. © 2021 Phcogj.Com. |
Liver; Lunasin; SGOT; SGPT; Soybean; Subchronic toxicity |
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Kusmardi K., Hairi B.N., Lubis N.S., Lestari T.W., Intan P.R. |
56966625300;57357912100;57222661567;57208401033;57357912200; |
The effect of sambiloto and spirulina combination on Mucin-1 protein expression in medial colon of Plasmodium berghei ANKA infected mice |
2021 |
Pharmacognosy Journal |
13 |
6 |
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1359 |
1365 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120320780&doi=10.5530%2fPJ.2021.13.172&partnerID=40&md5=1af1902c44df820801a8286e3e589f81 |
Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesia Medical Educational and Research Institute, Jakarta, Indonesia; Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jakarta, Indonesia; Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Parasitology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; National Institute of Health Research and Development, Ministry of Health of Indonesia, Jakarta, Indonesia; Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia |
Kusmardi, K., Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesia Medical Educational and Research Institute, Jakarta, Indonesia, Human Cancer Research Cluster, Indonesia Medical Educational and Research Institute, Jakarta, Indonesia, Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hairi, B.N., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lubis, N.S., Parasitology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lestari, T.W., National Institute of Health Research and Development, Ministry of Health of Indonesia, Jakarta, Indonesia; Intan, P.R., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia |
Malaria still be health problem in the world, especially in Eastern Indonesia. Malaria’s inflammation and metabolism defect can cause colonic damage, such as enhancement Muc-1 protein expression and goblet cells hyperplasia. Sambiloto and spirulina combination as antiinflammatory and antioxidative agent can prevent medial colon damage Plasmodium berghei ANKA infected mice. The aim of the study to show the effect of sambiloto and spirulina combination on Muc-1 protein activity in medial colon Plasmodium berghei ANKA infected mice. This study use preserve male Swiss Webser mice colonic tissue which has inoculated by Plasmodium berghei ANKA, whose treatment group include positive control (dehyroartemisin piperaquine), negative control (carboxymethil cellulose), AP (sambiloto), AP+ES (sambiloto+spirulina extract), and AP+PS (sambiloto+spirulina powder) and terminated after 28 days of treatment. Colonic tissue was stained with immunohistochemistry and observed using light microscope (400x) in five different field and was analyzed with ImageJ® sowtware, and statisitcal analysis was done with SPSS 20.0. According to One Way ANOVA and Duncan posthoc test, only AP+PS(120,98 ±3,37), which significantly difference between negative control, AP, and AP+ES group. Meanwhile, between DHP, AP+PS group not significantly differenece. Sambiloto extract and spirulina powder combination can reduce Muc-1 protein expression in medial colon Plasmodium berghei ANKA infected mice. © 2021 Phcogj.Com. |
Medial colon; Muc-1; Plasmodium berghei ANKA; Sambiloto; Spirulina |
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Viswanathan S., Hiew F.L., Siritho S., Apiwattanakul M., Tan K., Quek A.M.L., Estiasari R., Remli R., Bhaskar S., Islam B.M., Aye S.M.M., Ohnmar O., Umapathi T., Keosodsay S.S., Hoang N.T.T., Yeo T., Pasco P.M. |
56372225400;56520422700;15519966800;57195288799;37032197900;13605538000;55240204000;6504090091;57226417398;57194464797;55644071900;57201460031;6602092493;57201460833;57310352700;57310352800;6506559205; |
Impact of Covid-19 on the therapeutic plasma exchange service within the South East Asian region: Consensus recommendations and global perspectives |
2021 |
Journal of Clinical Apheresis |
36 |
6 |
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863 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117763064&doi=10.1002%2fjca.21937&partnerID=40&md5=3fb4e2326e829716a437226b18f33390 |
Department of Neurology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia; Department of Neurology, Bumrungrad International Hospital and Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Neurology, Neurological Institute of Thailand, Bangkok, Thailand; Department of Neurology, National Neuroscience Institute, Singapore; Division of Neurology, Department of Medicine, National University Health System, Singapore; Department of Neurology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Neurology, National University of Malaysia, Kuala Lumpur, Malaysia; Department of Medicine, Universiti Teknologi MARA, Sg Buloh, Selangor, Malaysia; Department of Laboratory Sciences and Services Division, The International Center for Diarrhoeal Disease Research, Dhaka, Bangladesh; Department of Neurology, Aryu International Hospital, Yangon, Myanmar; Department of Neurology, Yangon General Hospital, Yangon, Myanmar; Department of Neurology, Laos General Hospital, Vientiane, Laos; Department of Neurology, Military Hospital 175, Ho Chi Minh City, Viet Nam; Department of Neurosciences, Philippine General Hospital, Manila, Philippines |
Viswanathan, S., Department of Neurology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia; Hiew, F.L., Department of Neurology, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia; Siritho, S., Department of Neurology, Bumrungrad International Hospital and Siriraj Hospital, Mahidol University, Bangkok, Thailand; Apiwattanakul, M., Department of Neurology, Neurological Institute of Thailand, Bangkok, Thailand; Tan, K., Department of Neurology, National Neuroscience Institute, Singapore; Quek, A.M.L., Division of Neurology, Department of Medicine, National University Health System, Singapore; Estiasari, R., Department of Neurology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Remli, R., Department of Neurology, National University of Malaysia, Kuala Lumpur, Malaysia; Bhaskar, S., Department of Medicine, Universiti Teknologi MARA, Sg Buloh, Selangor, Malaysia; Islam, B.M., Department of Laboratory Sciences and Services Division, The International Center for Diarrhoeal Disease Research, Dhaka, Bangladesh; Aye, S.M.M., Department of Neurology, Aryu International Hospital, Yangon, Myanmar; Ohnmar, O., Department of Neurology, Yangon General Hospital, Yangon, Myanmar; Umapathi, T., Department of Neurology, National Neuroscience Institute, Singapore; Keosodsay, S.S., Department of Neurology, Laos General Hospital, Vientiane, Laos; Hoang, N.T.T., Department of Neurology, Military Hospital 175, Ho Chi Minh City, Viet Nam; Yeo, T., Department of Neurology, National Neuroscience Institute, Singapore; Pasco, P.M., Department of Neurosciences, Philippine General Hospital, Manila, Philippines |
Introduction: Therapeutic plasma exchange (TPE) for neuroimmunological disorders has played an increasingly important role within the Southeast Asian (SEA) region. The South East Asian Therapeutic Plasma exchange Consortium (SEATPEC) was formed in 2018 to promote education and research on TPE within the region. The advent of the Covid-19 pandemic has produced challenges for the development and expansion of this service. Methodology: A qualitative and semi-quantitative questionnaire-based survey was conducted by SEATPEC member countries from January to June 2020 (Phase 1) and then from July 2020 to January 2021 in (Phase 2) to assess the impact of Covid-19 on regional TPE. Objectives: The study's main objectives were to explore the challenges experienced and adaptations/adjustments taken by SEATPEC countries in order to continue safe and efficient TPE during the Covid-19 pandemic. Results: The pandemic was found to disrupt the delivery of TPE services in all SEATPEC countries. Contributing factors were multifactorial due to overstretched medical services, staff shortages, quarantines and redeployments, fear of acquiring Covid-19, movement restriction orders, and patient's psychological fear of attending hospitals/testing for Covid-19. All SEATPEC countries practiced careful stratification of cases for TPE (electives vs emergencies, Covid-19 vs non-Covid-19 cases). SEATPEC countries had to modify TPE treatment protocols to include careful preprocedure screening of patient's for Covid-19, use of personal protective equipment (PPE) and post-TPE sanitization of machines and TPE suites. Conclusion: Based on the responses of the survey, SEATPEC countries produced a consensus statement with five recommendations for safe and effective TPE within the region. © 2021 Wiley Periodicals LLC. |
Covid-19; impact; South East Asia; therapeutic plasma exchange |
complication; consensus; epidemiology; human; neurologic disease; neurologist; pandemic; plasma exchange; procedures; questionnaire; Southeast Asia; Asia, Southeastern; Consensus; COVID-19; Humans; Nervous System Diseases; Neurologists; Pandemics; Plasma Exchange; SARS-CoV-2; Surveys and Questionnaires |
John Wiley and Sons Inc |
07332459 |
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Raharja A., Tamara A., Kok L.T. |
57192080346;57205305387;57219901696; |
Association Between Ethnicity and Severe COVID-19 Disease: a Systematic Review and Meta-analysis |
2021 |
Journal of Racial and Ethnic Health Disparities |
8 |
6 |
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1563 |
1572 |
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8 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096023866&doi=10.1007%2fs40615-020-00921-5&partnerID=40&md5=139e8ff070e1e792a6383269e01b7342 |
Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Raharja, A., Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom; Tamara, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kok, L.T., Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom |
Objectives: This article evaluates if ethnicity is an independent poor prognostic factor in COVID-19 disease. Methods: MEDLINE, EMBASE, Cochrane, WHO COVID-19 databases from inception to 15/06/2020 and medRxiv. No language restriction. Newcastle-Ottawa Scale (NOS) and GRADE framework were utilised to assess the risk of bias and certainty of evidence. PROSPERO CRD42020188421. Results: Seventy-two articles (59 cohort studies with 17,950,989 participants, 13 ecological studies; 54 US-based, 15 UK-based; 41 peer-reviewed) were included for systematic review and 45 for meta-analyses. Risk of bias was low: median NOS 7 of 9 (interquartile range 6–8). Compared to White ethnicity, unadjusted all-cause mortality was similar in Black (RR: 0.96 [95% CI: 0.83–1.08]) and Asian (RR: 0.99 [0.85–1.16]) but reduced in Hispanic ethnicity (RR: 0.69 [0.57–0.84]). Age- and sex-adjusted risks were significantly elevated for Black (HR: 1.38 [1.09–1.75]) and Asian (HR: 1.42 [1.15–1.75]), but not for Hispanic (RR: 1.14 [0.93–1.40]). Further adjusting for comorbidities attenuated these associations to non-significance: Black (HR: 0.95 [0.72–1.25]); Asian (HR: 1.17 [0.84–1.63]); Hispanic (HR: 0.94 [0.63–1.44]). Subgroup analyses showed a trend towards greater disparity in outcomes for UK ethnic minorities, especially hospitalisation risk. Conclusions: This review could not confirm a certain ethnicity as an independent poor prognostic factor for COVID-19. Racial disparities in COVID-19 outcomes may be partially attributed to higher comorbidity rates in certain ethnicity. © 2020, W. Montague Cobb-NMA Health Institute. |
Acute kidney injury; COVID-19; Ethnicity; Hospitalisation; Intubation; Mortality |
ethnicity; ethnology; human; meta analysis; patient acuity; prognosis; risk factor; therapy; COVID-19; Ethnicity; Humans; Patient Acuity; Prognosis; Risk Factors |
Springer Science and Business Media Deutschland GmbH |
21973792 |
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33180278 |
Review |
Q1 |
644 |
7820 |
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|
|
82 |
Amanda G., Tafroji W., Sutoyo D.K., Burhan E., Haryanto B., Safari D. |
57193071364;57118271600;6506079672;36058554600;41861500300;23493586700; |
Serotype distribution and antimicrobial profile of Streptococcus pneumoniae isolated from adult patients with community-acquired pneumonia in Jakarta, Indonesia |
2021 |
Journal of Microbiology, Immunology and Infection |
54 |
6 |
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1175 |
1178 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094592942&doi=10.1016%2fj.jmii.2020.10.003&partnerID=40&md5=9c2a2f417f1387a35bf85921e1b795f4 |
Department Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Microbiology, Persahabatan Hospital, Jakarta, Indonesia |
Amanda, G., Department Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Tafroji, W., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Sutoyo, D.K., Department Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Burhan, E., Department Pulmonology and Respiratory Medicine Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia; Haryanto, B., Department of Microbiology, Persahabatan Hospital, Jakarta, Indonesia; Safari, D., Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Streptococcus pneumoniae is one of the primary causes of community-acquired pneumonia. The vaccine serotypes were dominant and could be isolated in 14% of adult patients, with serotype 3 being the most predominant (25%), followed by 6A, 6B, and 7F. Approximately, 44% of the isolates showed resistance to tetracycline. © 2020 |
Antibiotic resistance profile; Community-acquired pneumonia; Serotype; Streptococcus pneumoniae |
antiinfective agent; adolescent; adult; antibiotic resistance; community acquired infection; cross-sectional study; drug effect; female; genetics; human; Indonesia; isolation and purification; male; microbiology; middle aged; pneumonia; serotype; Streptococcus pneumoniae; young adult; Adolescent; Adult; Anti-Bacterial Agents; Community-Acquired Infections; Cross-Sectional Studies; Drug Resistance, Bacterial; Female; Humans; Indonesia; Male; Middle Aged; Pneumonia; Serogroup; Streptococcus pneumoniae; Young Adult |
Elsevier Ltd |
16841182 |
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33268305 |
Article |
Q1 |
1223 |
3210 |
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