No records
|
821 |
Wanandi S.I., Arumsari S., Afitriyansyah E., Syahrani R.A., Dewantara I.R., Nurachman L.A., Amin I.F., Haryono P.D., Budiman K., Sugiharta A.J., Remedika A.A., Taufikulhakim F.H., Iswanti F.C., Lee J.Y., Banerjee D. |
36099320700;57193202336;57223005545;57204103147;57223018344;57222663184;57188973524;57223016376;57223010670;57223013711;57223000993;57222619312;57192920851;57223019852;7202633380; |
Elevated extracellular co2 level affects the adaptive transcriptional response and survival of human peripheral blood mononuclear cells toward hypoxia and oxidative stress |
2021 |
Medical Journal of Indonesia |
30 |
1 |
|
5 |
12 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104485331&doi=10.13181%2fmji.oa.203810&partnerID=40&md5=bf8dedf67718ab440cf4f665b5af2f83 |
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biomedical Science Master Program, Rutgers-Robert Wood Johnson Medical SchoolNJ, United States; USAID Research Innovation Fellowship 2017, Washington, DC, United States; Department of Pharmacology, Rutgers-Robert Wood Johnson Medical SchoolNJ, United States |
Wanandi, S.I., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Arumsari, S., Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Afitriyansyah, E., Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Syahrani, R.A., Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dewantara, I.R., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nurachman, L.A., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Amin, I.F., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Haryono, P.D., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Budiman, K., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sugiharta, A.J., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Remedika, A.A., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Taufikulhakim, F.H., Undergraduate Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Iswanti, F.C., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Molecular Biology and Proteomics Core Facilities, Indonesian Medical and Education Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lee, J.Y., Biomedical Science Master Program, Rutgers-Robert Wood Johnson Medical SchoolNJ, United States, USAID Research Innovation Fellowship 2017, Washington, DC, United States; Banerjee, D., Department of Pharmacology, Rutgers-Robert Wood Johnson Medical SchoolNJ, United States |
BACKGROUND High carbon dioxide (CO2 ) level from indoor environments, such as classrooms and offices, might cause sick building syndrome. Excessive indoor CO2 level increases CO2 level in the blood, and over-accumulation of CO2 induces an adaptive response that requires modulation of gene expression. This study aimed to investigate the adaptive transcriptional response toward hypoxia and oxidative stress in human peripheral blood mononuclear cells (PBMCs) exposed to elevated CO2 level in vitro and its association with cell viability. METHODS PBMCs were treated in 5% CO2 and 15% CO2, representatives a high COâ‚‚ level condition for 24 and 48 hours. Extracellular pH (pHe) was measured with a pH meter. The levels of reactive oxygen species were determined by measuring superoxide and hydrogen peroxide with dihydroethidium and dichlorofluorescin-diacetate assay. The mRNA expression levels of hypoxia-inducible factor (HIF)-1α, HIF-2α, nuclear factor (NF)-κB, and manganese superoxide dismutase (MnSOD) were analyzed using a real-time reverse transcriptase-polymerase chain reaction (qRT-PCR). Cell survival was determined by measuring cell viability. RESULTS pHe increased in 24 hours after 15% COâ‚‚ treatment, and then decreased in 48 hours. Superoxide and hydrogen peroxide levels increased after the 24-and 48-hour of high COâ‚‚ level condition. The expression levels of NF-κB, MnSOD, HIF-1α, and HIF-2α decreased in 24 hours and increased in 48 hours. The increased antioxidant mRNA expression in 48 hours showed that the PBMCs were responsive under high CO2 conditions. Elevated CO2 suppressed cell viability significantly in 48 hours. CONCLUSIONS After 48 hours of high COâ‚‚ level condition, PBMCs showed an upregulation in genes related to hypoxia and oxidative stress to overcome the effects of CO2 elevation. © 2021 Authors. |
Elevated CO2; Extracellular pH; Oxidative stress; PBMC; Reactive oxygen species |
carbon dioxide; hydroethidine; hypoxia inducible factor 1alpha; hypoxia inducible factor 2alpha; immunoglobulin enhancer binding protein; manganese superoxide dismutase; messenger RNA; reactive oxygen metabolite; adult; Article; cell survival; cell viability; controlled study; extracellular space; gene expression; genetic transcription; human; human cell; human experiment; hypoxia; male; mRNA expression level; normal human; oxidative stress; peripheral blood mononuclear cell; pH; real time reverse transcription polymerase chain reaction; upregulation; young adult |
Faculty of Medicine, Universitas Indonesia |
08531773 |
|
|
Article |
Q4 |
164 |
21905 |
|
|
822 |
Ramlan A.A.W., Ratnaningrum A., Marsaban A.H.M. |
57195941841;57223018172;57195383833; |
A randomized controlled trial of infraorbital block using ketamine 1% for intra-and postoperative analgesia in children for ambulatory cleft lip correction |
2021 |
Medical Journal of Indonesia |
30 |
1 |
|
33 |
38 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104479826&doi=10.13181%2fmji.oa.204395&partnerID=40&md5=c08932eaa2373ffcc535ff0eadd8e55b |
Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anesthesiology, Fatmawati General Hospital, Jakarta, Indonesia |
Ramlan, A.A.W., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ratnaningrum, A., Department of Anesthesiology, Fatmawati General Hospital, Jakarta, Indonesia; Marsaban, A.H.M., Department of Anesthesiology and Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND In Indonesia, cleft lip correction surgery is often done as a social program in remote areas with limited resources. This study aimed to assess the effectiveness of ketamine, a cheaper and more accessible alternative, as a local analgesia in infraorbital block and to determine the possibility of ketamine as an alternative local analgesic drug for intraoperative and postoperative periods. METHODS This was a randomized controlled trial in children aged 2 months to 5 years who underwent cleft lip correction surgery at Cipto Mangunkusumo Hospital in 2016. Subjects were randomly divided into two groups: ketamine and bupivacaine. Standard general anesthesia with endotracheal intubation was performed in each group. Bilateral intraoral infraorbital block was performed using ketamine 1% 0.5 ml or bupivacaine 0.25% 0.5 ml. Postoperative evaluation includes pain scores based on the face, leg, activity, cry, and consolability (FLACC) scale and analgesic duration. RESULTS A total of 36 subjects were enrolled in this study, with 18 in each group. Both groups received the same total amount of fentanyl addition intraoperatively (p = 1). The postoperative FLACC pain scale scores between the two groups were not different, with p>0.05 in every measurement. The mean duration of postoperative analgesia in the ketamine group was longer than the bupivacaine group (15–13.49 hours, p = 0.031). CONCLUSIONS Infraorbital block with 1% ketamine 0.5 mg/kg was similarly effective for intraoperative and postoperative analgesia but had a longer duration than that with 0.25% bupivacaine 0.5 ml in ambulatory cleft lip correction. © 2021 Authors. |
Cleft lip; Ketamine; Postoperative pain |
bupivacaine; epinephrine; fentanyl; ketamine; paracetamol; sevoflurane; Article; breathing rate; child; cleft lip; cleft palate; clinical article; controlled study; endotracheal intubation; female; FLACC scale; follow up; general anesthesia; hemodynamics; human; infant; infraorbital nerve; infraorbital nerve block; intraoperative period; male; nerve block; pain assessment; postoperative analgesia; postoperative pain; pulse rate; randomized controlled trial; single blind procedure; telephone interview; visual analog scale |
Faculty of Medicine, Universitas Indonesia |
08531773 |
|
|
Article |
Q4 |
164 |
21905 |
|
|
823 |
Sarika D.T., Louisa M., Rozaliyani A., Evelina, Susiyanti M. |
57223018187;41461551400;57203065912;57223007552;19640377300; |
Efficacy of adjuvant intrastromal and combination of intrastromal and intracameral voriconazole in aspergillus fumigatus-induced moderate fungal keratitis in rabbits |
2021 |
Medical Journal of Indonesia |
30 |
1 |
|
13 |
19 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104464172&doi=10.13181%2fmji.oa.203726&partnerID=40&md5=6021b6878c47eb4ccde69bba65f51abb |
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sarika, D.T., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rozaliyani, A., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Evelina, Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Susiyanti, M., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND There is no in vivo evidence for the effectiveness of adjuvant intrastromal and combination of intrastromal and intracameral voriconazole (VCZ) for treating Aspergillus fumigatus keratitis. This study aimed to compare the efficacy of both agents against it. METHODS A randomized, masked, controlled experimental study was conducted on 11 albino New Zealand white rabbits in which moderate fungal keratitis was induced by inoculating spores of A. fumigatus to the cornea. The rabbits were allocated into 3 groups: 50 μg/0.1 ml intrastromal VCZ injection, 50 μg/0.1 ml intrastromal and intracameral VCZ injections, and topical VCZ (control). The treatment was given 5 days after inoculation. Epithelial defect, infiltrate size, corneal ulcer depth, and hypopyon were evaluated clinically. Histopathological and mycological examinations were also done 14 days after treatment. RESULTS All rabbits in the adjuvant treatment groups demonstrated a tendency of a better clinical response with decreasing size of epithelial defect (p = 0.679) and infiltrate (p = 0.755) than in the control group. Direct microscopy, corneal culture, and chop corneal tissue culture were still positive in most of the rabbits from all groups. Histopathological examination showed an increase of inflammatory cells after treatment in all groups, especially in rabbits which were inoculated with A. fumigatus spores in both eyes. CONCLUSIONS An adjuvant combination of intrastromal and intracameral VCZ showed a tendency of better clinical response for A. fumigatus-induced moderate fungal keratitis in rabbits. © 2021 Authors. |
Aspergillus fumigatus; Fungal keratitis; Intrastromal; Voriconazole |
eye drops; ketamine; pentobarbital; potassium hydroxide; prednisone acetate; tetracaine; voriconazole; xylazine; animal experiment; animal model; animal tissue; Article; Aspergillus fumigatus; controlled study; cornea injury; cornea ulcer; corneal scraping; disk diffusion; drug efficacy; follow up; fungal examination; histopathology; hypopyon; inflammation; intrastromal drug administration; keratectomy; keratomycosis; Leporidae; male; nonhuman; treatment response |
Faculty of Medicine, Universitas Indonesia |
08531773 |
|
|
Article |
Q4 |
164 |
21905 |
|
|
824 |
Agung N.P., Nadhif M.H., Irdam G.A., Mochtar C.A. |
57222963984;57189057498;57194729795;6506558321; |
The Role of 3D-Printed Phantoms and Devices for Organ-specified Appliances in Urology |
2021 |
International Journal of Bioprinting |
7 |
2 |
|
1 |
14 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104261313&doi=10.18063%2fIJB.V7I2.333&partnerID=40&md5=0bbeefb808ac4fbf51023802ccfa25db |
Department of Urology, Universitas Indonesia, Faculty of Medicine/Ciptomangunkusumo Central Hospital, Jakarta, Indonesia; Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Technology Cluster, Indonesian Medical Education and Research Institute, Jakarta, Indonesia |
Agung, N.P., Department of Urology, Universitas Indonesia, Faculty of Medicine/Ciptomangunkusumo Central Hospital, Jakarta, Indonesia; Nadhif, M.H., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Medical Technology Cluster, Indonesian Medical Education and Research Institute, Jakarta, Indonesia; Irdam, G.A., Department of Urology, Universitas Indonesia, Faculty of Medicine/Ciptomangunkusumo Central Hospital, Jakarta, Indonesia; Mochtar, C.A., Department of Urology, Universitas Indonesia, Faculty of Medicine/Ciptomangunkusumo Central Hospital, Jakarta, Indonesia |
Urology is one of the fields that are always at the frontline of bringing scientific advancements into clinical practice, including 3D printing (3DP). This study aims to discuss and presents the current role of 3D-printed phantoms and devices for organ-specified applications in urology. The discussion started with a literature search regarding the two mentioned topics within PubMed, Embase, Scopus, and EBSCOhost databases. 3D-printed urological organ phantoms are reported for providing residents new insight regarding anatomical characteristics of organs, either normal or diseased, in a tangible manner. Furthermore, 3D-printed organ phantoms also helped urologists to prepare a pre-surgical planning strategy with detailed anatomical models of the diseased organs. In some centers, 3DP technology also contributed to developing specified devices for disease management. To date, urologists have been benefitted by 3D-printed phantoms and devices in the education and disease management of organs of in the genitourinary system, including kidney, bladder, prostate, ureter, urethra, penis, and adrenal. It is safe to say that 3DP technology can bring remarkable changes to daily urological practices. © 2021 Agung, et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
3D printing; Devices; Phantoms; Urology |
|
Whioce Publishing Pte. Ltd. |
24248002 |
|
|
Article |
Q1 |
1014 |
4306 |
|
|
825 |
Wardoyo S., Pardede J.P.P., Asari H.A. |
57211106608;57222900416;57222898312; |
Patients’ characteristics following reoperation after modified blalock-taussig shunt (Mbts) in cardiac centre national general hospital cipto mangunkusumo from 2018-2020 |
2021 |
Bali Medical Journal |
10 |
1 |
|
103 |
107 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104181375&doi=10.15562%2fbmj.v10i1.2124&partnerID=40&md5=71f0e48c1ff1cce6ec58341517f2fb6a |
Thoracic, Cardiac, and Vascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Wardoyo, S., Thoracic, Cardiac, and Vascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pardede, J.P.P., Thoracic, Cardiac, and Vascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Asari, H.A., Thoracic, Cardiac, and Vascular Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Background: Modified Blalock-Taussig shunt (MBTS) is a common palliative procedure for congenital heart defect to connect the systemic to the pulmonary circulation via a synthetic shunt from a subclavian artery to a pulmonary artery. However, certain postoperative complications do exist, such as blockage. Early identification of modifiable risk factors is important to prompt early intervention for better outcomes. Material: This article is a descriptive narrative retrospective study. We gather data from the Cipto Mangunkusumo Hospital Cardiovascular Center medical report of 8 patients having undergone reoperation post-MBTS surgery as their first operation between January 2018 and October 2020. Data were analyzed using SPSS version 20 for Windows. Results: The patient’s age ranged from 3 months to 30 years old. Seven of them suffered from shunt occlusion complications, while the other suffered from the bleeding problem. The laboratory results showed that preoperative hemoglobin (18.9±4.1 g/dL vs. 16.90 (10.80-19.20) g/dL), hematocrit (58.8±12.40% vs. 42.9±14.30%), platelet counts (284.487±147.003 vs. 210.625±104.688) 103/uL, and oxygen saturation (86.00 (75.00-89.00) vs. 70.00±17.00) levels were higher than the pre-reoperative. The coagulation markers showed that PT value has increasing trend (1.10 (0.90-2.30) vs. 1.30±0.20) while aPTT (5.90 (2.90-6.30) vs. 2.30 (1.60-5.30)) seconds and activated clotting time (ACT) (205.00±86.00 vs. 165.00 (114.00-255.00)) showed the opposite. Conclusion: MBTS remains the first-choice bridging palliation surgery to increase the pulmonary blood flow in congenital heart defects. The cause of shunt failure remains inconclusive in this study. Other studies suggest that graft material choice, S/PA ratio, S/W ratio, operative approach, thrombus formation, and aPTT value contribute to shunt failure, thus needing a reoperation. © 2021, Sanglah General Hospital. All rights reserved. |
Characteristic; Modified Blalock-Taussig Shunt; Re-operation |
|
Sanglah General Hospital |
20891180 |
|
|
Article |
#N/A |
#N/A |
#N/A |
|
|
826 |
Irawati Y., Soedarman S., Arianti A., Widyasari A., Reksodiputro M.H. |
57201260313;57222867991;57201999421;57280734100;35090488800; |
Multiple approaches for managing complex ophthalmic blunt trauma: A case report |
2021 |
International Medical Case Reports Journal |
14 |
|
|
205 |
210 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104124100&doi=10.2147%2fIMCRJ.S304193&partnerID=40&md5=1d5a9d9b836b19267fc2e128d84efc72 |
Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Orbital and Oculoplastic Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Vitreo- Retina Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Neuro- Ophthalmology Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Division of Plastic Reconstruction, Department of Ear, Nose and Throat, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irawati, Y., Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Orbital and Oculoplastic Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Soedarman, S., Vitreo- Retina Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Arianti, A., Neuro- Ophthalmology Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Widyasari, A., JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Reksodiputro, M.H., Division of Plastic Reconstruction, Department of Ear, Nose and Throat, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Ophthalmic trauma is defined as injuries affecting the ocular structures, including the globe, eyelid, lacrimal system, and surrounding orbital walls. Blunt trauma acts as the leading cause of injury and it may affect both the anterior and posterior parts of the globe. Prompt diagnosis, early management, and sustained follow-up are mandatory for an optimal outcome. Purpose: This report presents a one-step surgery management process for an intricate case of blunt facial trauma with complex ophthalmic and nasal injury. Patients and Methods: A 45-year-old male with blunt force trauma of the left eye from a wooden block, suffered from naso-orbital-ethmoidal fractures, eyelid laceration with canalicular, close-globe injuries of traumatic cataract and vitreous hemorrhage with retinal detachment. A simultaneous one-step surgery was performed by a trauma team of ophthalmological and ENT surgeons during the height of the COVID-19 pandemic to lessen the risk of cross-transmission. After ruling out the possibility of open-globe rupture, traumatic cataract extraction, retinal detachment surgery, the repair of an eyelid laceration with canalicular involvement, and septorhinoplasty were performed on concomitantly. Results: Anatomical success was achieved for the repair of the nasoorbitoethmoidal (NOE) type II fracture and close-globe injuries, including the anatomical reattachment of the retina. However, the functional outcome remained unsatisfactory. Visual acuity failed to show further improvement at a later follow-up. Traumatic optic neuropathy was, at the final follow-up, considered to be the cause of the suboptimal visual acuity. Conclusion: A single-step multi-procedure for a complex ophthalmic blunt trauma, as demonstrated in this case, may be beneficial for reducing the complications that might arise due to treatment delay. The complex nature of the injury, however, creates the higher possibility for residual post-operative complications. Risks of residual functional impairment should be considered in such complex trauma prior to surgery, to determine the surgical prognostic value and provide appropriate consent to the patient. © 2021 Irawati et al. |
Blunt trauma; Canalicular laceration; Closed-globe injury; Facial injury; Nasal fracture; Ocular trauma |
adult; Article; blunt trauma; case report; cataract; clinical article; clinical examination; conjunctival hemorrhage; crackle; epistaxis; ethmoid bone; eye injury; eyelid closure; eyelid disease; eyelid reconstruction; face fracture; human; hyphema; Indonesia; laceration; lens implantation; male; middle aged; nasopharyngeal swab; nose injury; nose septum reconstruction; occupational accident; orbit fracture; postoperative care; retina detachment; ultrasound; visual acuity; vitrectomy; vitreous hemorrhage |
Dove Medical Press Ltd |
1179142X |
|
|
Article |
Q4 |
198 |
19482 |
|
|
827 |
Haryanto T., Suhartanto H., Arymurthy A.M., Kusmardi K. |
57193869197;16423632300;36815724000;56966625300; |
Conditional sliding windows: An approach for handling data limitation in colorectal histopathology image classification |
2021 |
Informatics in Medicine Unlocked |
23 |
|
100565 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104075953&doi=10.1016%2fj.imu.2021.100565&partnerID=40&md5=dceb8084f0a81f31189f09578a878d62 |
Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia; Department of Computer Science, IPB University, Kampus IPB Dramaga, Bogor, 16680, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Kampus Universitas Indonesia, Jakarta, Indonesia |
Haryanto, T., Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia, Department of Computer Science, IPB University, Kampus IPB Dramaga, Bogor, 16680, Indonesia; Suhartanto, H., Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia; Arymurthy, A.M., Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia; Kusmardi, K., Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Kampus Universitas Indonesia, Jakarta, Indonesia |
Large amounts of data are required for the training process with a convolutional neural network (CNN) because small datasets with low variation will cause over-fitting, and the model cannot predict new data with high accuracy. Additionally, the non-availability of histopathological medical data presents an issue because without ethical permission, such data cannot be obtained easily. Therefore, this study proposes a conditional sliding window algorithm to obtain sub-sample data on images of histopathology. Two sets of original data were used, one from the Warwick dataset with dimensions of 775 × 522 pixels and the other from the Department of Pathology and Anatomy, Faculty of Medicine Universitas Indonesia. The algorithm used was inspired by the conventional sliding window method, but implemented with added conditions, such as sliding the window algorithm from the left on (x,y) pixel coordinates, thereby moving from left to right, then up to down until the entire image was covered. Consequently, the new image was produced with two dimensions: 200 × 200 and 300 × 300 pixels. However, to avoid loss of information, the 25 and 50 pixels overlap were used. In this study, CNN 7-5-7 was designed and proposed to perform the process. The conditional sliding window algorithm can produce various sub-samples depending on the image and window size. Furthermore, the images produced were used to develop a CNN and were proven to accurately predict benign and malignant tissues compared to the model from the original dataset. Moreover, the sensitivity values of the Warwick public dataset and the one generated in this study are above 0.80, which shows that the proposed CNN architecture is more stable compared to the existing methods such as AlexNet and DenseNet121. This study succeeded in solving the limitations of colorectal histopathological training data by developing a conditional sliding window algorithm. This algorithm can be applied to generate other histopathological data. Moreover, our proposed CNN 7-5-7 is the fastest architecture for training, comparable to state-of-the-art methodologies. Furthermore, the dataset was used to develop the model for colorectal cancer identification and integrated on the web-based application for further implementation. © 2021 The Authors |
Augmentation; Conditional sliding windows; Convolutional neural network; Histopathology |
Article; colorectal cancer; computer language; convolutional neural network; deep learning; diagnostic accuracy; entropy; feature extraction; histopathology; human; image processing; information processing; learning algorithm; sensitivity and specificity |
Elsevier Ltd |
23529148 |
|
|
Article |
Q3 |
440 |
11223 |
|
|
828 |
Suryana K.D., Simadibrata M., Renaldi K. |
57222750873;23499598400;57190963547; |
Impact of COVID-19 on the Gut: A Review of the Manifestations, Pathology, Management, and Challenges |
2021 |
Acta medica Indonesiana |
53 |
1 |
|
96 |
104 |
|
4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103994291&partnerID=40&md5=8f9253303dd7921abe223346263c353b |
Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Dr. Cipto Mangunkusumo General Hospital National HospitalJakarta, Indonesia |
Suryana, K.D., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Dr. Cipto Mangunkusumo General Hospital National HospitalJakarta, Indonesia; Simadibrata, M.; Renaldi, K. |
SARS-CoV-2 is a virus that can enter its hosts through the Angiotensin Converting Enzyme-2 (ACE2) receptor. ACE2 is mainly expressed in cells of the gastrointestinal tract, such as the esophageal epithelium and enterocytes from the ileum-colon. Coronavirus Disease 2019 (COVID-19) has varying clinical symptoms and presents differently in individuals, ranging from asymptomatic carriers to moderate clinical spectrum with mild pneumonia clinical features, and to a severe clinical presentation with dyspnea and hypoxia, leading to death due to respiratory or multi-organ failure. COVID-19 infection can also manifest themselves in the form of gastrointestinal symptoms such as diarrhea, vomiting, nausea, and abdominal pain. Severe complications of gastrointestinal COVID-19 infections include hemorrhage or perforation of the gastrointestinal tract and severe inflammation, which can adversely affect the intestinal immune system, and therefore the systemic immune system of the host. Furthermore, COVID-19 has also shown to affect microbiota homeostasis in the digestive tract. To date, no clear explanation is available regarding the pathophysiology of gastrointestinal SARS-CoV-2 infection, fecal RNA detection, and the possibility of fecal-oral transmission of SARS-CoV-2. This review aims to discuss the effects of SARS-CoV-2 infection on the digestive tract, microbiota, and lung, and the possibility of fecal-oral transmission in COVID-19. |
Gastroenterology; Hepatology; Infection; Internal medicine; Pulmonology; Tropical disease |
feces; gastrointestinal disease; gastrointestinal tract; human; immunology; isolation and purification; pathogenicity; pathophysiology; physiology; prevention and control; virology; COVID-19; Feces; Gastrointestinal Diseases; Gastrointestinal Tract; Humans; SARS-CoV-2 |
NLM (Medline) |
01259326 |
|
33818412 |
Review |
Q3 |
321 |
14162 |
|
|
829 |
Azwar M.K., Setiati S. |
57202798959;14325991900; |
Modifiable Risk Factors for Dementia in Indonesia's Urban Population |
2021 |
Acta medica Indonesiana |
53 |
1 |
|
31 |
41 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103993731&partnerID=40&md5=7f5fcb58c59d74fc45c0cac2c49add86 |
Faculty of Medicine Universitas IndonesiaJakarta, Indonesia |
Azwar, M.K., Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Setiati, S. |
BACKGROUND: Indonesia is one of ten countries in the world with estimated number of dementia case exceeding a million. The number of elderly population living in Indonesian cities has exceeded the number in rural areas, but the country lacks data representing the urban population better related to modifiable risk factors for dementia, prevention of which is crucial. We aimed to identify the modifiable risk factors for dementia in Indonesia's urban population. METHODS: this case-control study used five-year data in Indonesia's national general hospital by tracing back medical record books of individuals aged 60 years and above in geriatric medicine outpatient clinic to the first hospital visit. Statistical analyses included bivariate and multivariate analyses to adjust for confounding factors appropriately. RESULTS: data from 345 patients suggested that the significant risk factors for dementia were history of smoking (adjusted OR 2.860, 95% CI 1.559-5.246), history of hearing loss (adjusted OR 7.962, 95% CI 3.534-17.941), history of depression (adjusted OR 12.473, 95% CI 2.533-61.417), hypertension (adjusted OR 1.751, 95% CI 1.006-3.048), and diabetes mellitus (adjusted OR 2.561, 95% CI 1.482-4.425). Dementia patients had longer median duration of diabetes mellitus (12 years) than elderly without dementia (9 years) before the diagnosis of dementia. Single point late-life underweight condition and low educational attainment were not associated with dementia in Indonesia's urban setting. The risk factors for vascular dementia were largely similar to those of dementia. CONCLUSION: in Indonesian urban population, history of smoking, hearing loss, depression, hypertension, and diabetes mellitus are associated with dementia. |
city; dementia; Indonesia; Jakarta; risk factor; urban |
adverse event; aged; case control study; complication; dementia; depression; diabetes mellitus; female; hearing impairment; human; hypertension; Indonesia; male; middle aged; multivariate analysis; risk factor; smoking; statistical model; urban population; very elderly; Aged; Aged, 80 and over; Case-Control Studies; Dementia; Depression; Diabetes Mellitus; Female; Hearing Loss; Humans; Hypertension; Indonesia; Logistic Models; Male; Middle Aged; Multivariate Analysis; Risk Factors; Smoking; Urban Population |
NLM (Medline) |
01259326 |
|
33818405 |
Article |
Q3 |
321 |
14162 |
|
|
830 |
Wicaksono I., Rahardjo H.E. |
57217251974;37762030000; |
Diagnostic Value of PCR compared to Urine Culture for Urinary Tuberculosis in Adult Women: An Evidence-Based Case Report |
2021 |
Acta medica Indonesiana |
53 |
1 |
|
108 |
118 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103993519&partnerID=40&md5=7a612f7f41fa8ec9b31840cc9700f185 |
Department of Urology, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Wicaksono, I., Department of Urology, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Rahardjo, H.E. |
BACKGROUND: genitourinary tuberculosis (GUTB) refers to a Mycobacterium tuberculosis infection of the urinary tract with clinical manifestation masquerading as various urological diagnostic entities. With an incidence rate of 192-232 per 100,000 individuals, current diagnoses have fallen short in comparison to the total incidence. Combined with an atypical and non-specific manifestation, a high false negative rate of acid-fast bacilli (AFB) staining, and long AFB culture duration has made diagnosis difficult. We aim to gather current available evidence regarding the diagnostic performance of polymerase chain reaction (PCR) in the diagnosis of GUTB. METHODS: a literature search was conducted in four different, well-known databases using a predetermined PICO, keywords, and Boolean operators. All included articles will be subjected to rigorous appraisal according the University of Oxford's Centre for Evidence-Based Medicine (CEBM) Diagnostic Variability Criteria. Review and meta-analysis will be subjected to the QFAITH appraisal checklist to assess its quality. RESULTS: out of a total of 243 initial search results, 11 relevant studies were determined after title and abstract screening. Additionally, nine articles were excluded based on the predetermined criteria. Two fully appraised articles were included in the study: one systematic review article, revealing a heterogenous (I2 = unstated; p = unstated) result of sensitivity mean above 85% and specificity above 75%; and one cross-sectional diagnostic study that reported the use of two different PCR primers: IS6110-PCR and 16SrRNA-PCR primer with a sensitivity of 95.99% and 87.05% and specificity of 98.11% and 98.9%, respectively. CONCLUSION: current limited evidence showed that PCR could not be solely used for the diagnosis of GUTB, but its use is recommended to guide patient treatment and monitoring. |
acid-fast bacilli; diagnosis; genitourinary tuberculosis; polymerase chain reaction; urine culture |
adult; case report; comparative study; evidence based practice; female; genetics; human; isolation and purification; meta analysis; microbiology; Mycobacterium tuberculosis; polymerase chain reaction; sensitivity and specificity; urine; urogenital tuberculosis; Adult; Evidence-Based Practice; Female; Humans; Mycobacterium tuberculosis; Polymerase Chain Reaction; Sensitivity and Specificity; Tuberculosis, Urogenital; Urine |
NLM (Medline) |
01259326 |
|
33818414 |
Article |
Q3 |
321 |
14162 |
|
|