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81 |
Raharja A., Tamara A., Kok L.T. |
57192080346;57205305387;57219901696; |
Association Between Ethnicity and Severe COVID-19 Disease: a Systematic Review and Meta-analysis |
2021 |
Journal of Racial and Ethnic Health Disparities |
8 |
6 |
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1563 |
1572 |
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8 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096023866&doi=10.1007%2fs40615-020-00921-5&partnerID=40&md5=139e8ff070e1e792a6383269e01b7342 |
Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Raharja, A., Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom; Tamara, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kok, L.T., Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom |
Objectives: This article evaluates if ethnicity is an independent poor prognostic factor in COVID-19 disease. Methods: MEDLINE, EMBASE, Cochrane, WHO COVID-19 databases from inception to 15/06/2020 and medRxiv. No language restriction. Newcastle-Ottawa Scale (NOS) and GRADE framework were utilised to assess the risk of bias and certainty of evidence. PROSPERO CRD42020188421. Results: Seventy-two articles (59 cohort studies with 17,950,989 participants, 13 ecological studies; 54 US-based, 15 UK-based; 41 peer-reviewed) were included for systematic review and 45 for meta-analyses. Risk of bias was low: median NOS 7 of 9 (interquartile range 6–8). Compared to White ethnicity, unadjusted all-cause mortality was similar in Black (RR: 0.96 [95% CI: 0.83–1.08]) and Asian (RR: 0.99 [0.85–1.16]) but reduced in Hispanic ethnicity (RR: 0.69 [0.57–0.84]). Age- and sex-adjusted risks were significantly elevated for Black (HR: 1.38 [1.09–1.75]) and Asian (HR: 1.42 [1.15–1.75]), but not for Hispanic (RR: 1.14 [0.93–1.40]). Further adjusting for comorbidities attenuated these associations to non-significance: Black (HR: 0.95 [0.72–1.25]); Asian (HR: 1.17 [0.84–1.63]); Hispanic (HR: 0.94 [0.63–1.44]). Subgroup analyses showed a trend towards greater disparity in outcomes for UK ethnic minorities, especially hospitalisation risk. Conclusions: This review could not confirm a certain ethnicity as an independent poor prognostic factor for COVID-19. Racial disparities in COVID-19 outcomes may be partially attributed to higher comorbidity rates in certain ethnicity. © 2020, W. Montague Cobb-NMA Health Institute. |
Acute kidney injury; COVID-19; Ethnicity; Hospitalisation; Intubation; Mortality |
ethnicity; ethnology; human; meta analysis; patient acuity; prognosis; risk factor; therapy; COVID-19; Ethnicity; Humans; Patient Acuity; Prognosis; Risk Factors |
Springer Science and Business Media Deutschland GmbH |
21973792 |
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33180278 |
Review |
Q1 |
644 |
7820 |
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217 |
Kurnia K.H., Elvioza, Sidik M., Sari T.T., Prihartono J., Sitorus R.S. |
57222405280;57205416912;56252760000;36519483600;6602605635;57221587271; |
Novel retinal findings in β-thalassemia major: older age and higher ferritin level as the risk factors |
2021 |
Graefe's Archive for Clinical and Experimental Ophthalmology |
259 |
9 |
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2633 |
2641 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102635685&doi=10.1007%2fs00417-021-05141-z&partnerID=40&md5=bf7abc1182072dd50cdf5ec7be6fa742 |
Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Kurnia, K.H., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Elvioza, Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Sidik, M., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Sari, T.T., Department of Child Health, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Prihartono, J., Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sitorus, R.S., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Purpose: To investigate retinal changes in β-thalassemia major patients and identify their association with systemic risk factors. Methods: In this prospective study, 120 β-thalassemia major patients received complete ophthalmic examinations (best-corrected visual acuity, contrast sensitivity, color vision, and indirect ophthalmoscopy) and retinal imaging using color fundus photography and fundus autofluorescence imaging. Patients were grouped according to the presence of thalassemia-related retinal changes. The association between systemic risk factors (age, type and duration of iron chelator use, history of splenectomy, hemoglobin level, and ferritin level) and thalassemia-related retinal changes was investigated using logistic regression analysis. Results: Thalassemia-related retinal changes were identified in 36.7% of patients. Several distinct retinal changes were observed, including retinal refractile bodies in 10% of patients and retinal hemorrhage in 5.8% of patients. Fundus autofluorescence imaging showed abnormal patterns in 36.3% of patients with thalassemia-related retinal changes and 18.4% of patients without thalassemia-related retinal changes. Age (odds ratio [OR] = 1.10, 95% confidence interval [CI] 1.03–1.18) and ferritin level (OR 1.16, 95% CI 1.01–1.33) were associated with thalassemia-related retinal changes. Conclusion: Novel retinal changes were observed in β-thalassemia major patients. This study identified older age and higher ferritin level as risk factors for thalassemia-related retinal changes. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
Ferritin; Fundus autofluorescence imaging; Iron chelator; Retinal changes; β-Thalassemia major |
deferasirox; deferiprone; deferoxamine; ferritin; hemoglobin; ferritin; adult; age; angioid streak; Article; autofluorescence imaging; best corrected visual acuity; blood transfusion; branch retinal vein occlusion; color vision; contrast sensitivity; controlled study; drusen; epithelium hyperplasia; eye fundus; eye photography; female; ferritin blood level; hemoglobin blood level; human; Indonesia; major clinical study; male; melanocytosis; observational study; ophthalmoscopy; optic disk anomaly; optical coherence tomography; papilledema; patient history of surgery; prospective study; retina disease; retina examination; retina hemorrhage; retina pigment degeneration; slit lamp microscopy; splenectomy; subretinal neovascularization; thalassemia major; treatment duration; aged; beta thalasse |
Springer Science and Business Media Deutschland GmbH |
0721832X |
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33738624 |
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3322 |
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221 |
Qu L.G., Perera M., Lawrentschuk N., Umbas R., Klotz L. |
57204687809;56544134500;57217501609;6602634832;55040556500; |
Scoping review: hotspots for COVID-19 urological research: what is being published and from where? |
2021 |
World Journal of Urology |
39 |
9 |
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3151 |
3160 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090474581&doi=10.1007%2fs00345-020-03434-2&partnerID=40&md5=02d48bd6f6edec3e634ad6f1c71c4628 |
Olivia Newton John Cancer Research Institute, Austin Health, Melbourne, VIC, Australia; Department of Surgery, University of Melbourne, Melbourne, VIC, Australia; Department of Urology, Austin Health, Heidelberg, VIC, Australia; Department of Urology, The Royal Melbourne Hospital, Melbourne, VIC, Australia; EJ Whitten Prostate Cancer Research Centre at Epworth, Melbourne, VIC, Australia; Department of Urology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada |
Qu, L.G., Olivia Newton John Cancer Research Institute, Austin Health, Melbourne, VIC, Australia, Department of Surgery, University of Melbourne, Melbourne, VIC, Australia, Department of Urology, Austin Health, Heidelberg, VIC, Australia; Perera, M., Olivia Newton John Cancer Research Institute, Austin Health, Melbourne, VIC, Australia, Department of Surgery, University of Melbourne, Melbourne, VIC, Australia; Lawrentschuk, N., Department of Surgery, University of Melbourne, Melbourne, VIC, Australia, Department of Urology, The Royal Melbourne Hospital, Melbourne, VIC, Australia, EJ Whitten Prostate Cancer Research Centre at Epworth, Melbourne, VIC, Australia; Umbas, R., Department of Urology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Klotz, L., Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada |
Purpose: Contemporary, original research should be utilised to inform guidelines in urology relating to the COVID-19 pandemic. This comprehensive review aimed to: identify all up-to-date original publications relating to urology and COVID-19, characterise where publications were from, and outline what topics were investigated. Methods: This review utilised a search strategy that assessed five electronic databases, additional grey literature, and global trial registries. All current published, in-press, and pre-print manuscripts were included. Eligible studies were required to be original research articles of any study design, reporting on COVID-19 or urology, in any of study population, intervention, comparison, or outcomes. Included studies were reported in a narrative synthesis format. Data were summarised according to primary reported outcome topic. A world heatmap was generated to represent where included studies originated from. Results: Of the 6617 search results, 48 studies met final inclusion criteria, including 8 pre-prints and 7 ongoing studies from online registries. These studies originated from ten countries according to first author affiliation. Most studies originated from China (n = 13), followed by Italy (n = 12) and USA (n = 11). Topics of the study included pathophysiological, administrative, and clinical fields: translational (n = 14), COVID-19-related outcomes (n = 5), urology training (n = 4), telemedicine (n = 7), equipment and safety (n = 2), urology in general (n = 4), uro-oncology (n = 3), urolithiasis (n = 1), and kidney transplantation (n = 8). Conclusion: This review has outlined available original research relevant to COVID-19 and urology from the international community. This summary may serve as a guide for future research priorities in this area. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature. |
COVID-19; Kidney transplantation; Telemedicine; Training; Uro-oncology; Urology |
epidemiology; global health; human; kidney transplantation; medical research; oncology; organization and management; prevention and control; procedures; publishing; telemedicine; urology; Biomedical Research; COVID-19; Global Health; Humans; Kidney Transplantation; Medical Oncology; Publishing; SARS-CoV-2; Telemedicine; Urology |
Springer Science and Business Media Deutschland GmbH |
07244983 |
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32909171 |
Article |
Q1 |
1552 |
2143 |
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360 |
Yunir E., Tahapary D.L., Tarigan T.J.E., Harbuwono D.S., Oktavianda Y.D., Kristanti M., Iswati E., Sarumpaet A., Soewondo P. |
36520254800;55944492500;36057746500;36056341600;57224499358;57208222835;57224505254;57193017794;23475336100; |
Non-vascular contributing factors of diabetic foot ulcer severity in national referral hospital of Indonesia |
2021 |
Journal of Diabetes and Metabolic Disorders |
20 |
1 |
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805 |
813 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107722068&doi=10.1007%2fs40200-021-00827-x&partnerID=40&md5=b307a628bc17237466c173d4d63b13aa |
Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Yunir, E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tahapary, D.L., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tarigan, T.J.E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harbuwono, D.S., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktavianda, Y.D., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kristanti, M., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Iswati, E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sarumpaet, A., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soewondo, P., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: Diabetic foot ulcer (DFU) is a common chronic complication of type 2 diabetes mellitus (T2DM) in Indonesia, with a prevalence of 7.3%. However, the characteristics of these patients remain unclear. We investigated the characteristics of patients with DFU without peripheral arterial disease (PAD) and analyzed non-vascular factors related to severity of DFU in a tertiary care national referral hospital in Indonesia. Methods: This was a cross-sectional study including 123 hemodynamically stable DFU patients without PAD recruited from Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia from 2010–2015. Results: DFU patients were predominantly over 50 years old (75.6%) and diagnosed with T2DM for 5 years with poor glycemic control (82.7%) and peripheral neuropathy (91.3%). Most patients had anemia (86.7%), leukocytosis (84.6%), and were undernourished, as characterized by a low lipid profile (90.8%) and hypoalbuminemia (83.7%). Most had extensive size of ulcer at the initial visit, with a median size of 16.23 (2.92–60.16) cm2. Ulcers were mostly located of the forefoot (62.5%) and were caused by mechanical trauma (46.2%). Bivariate analysis revealed that significant factors for the development of DFU were related to DFU size, including duration of T2DM (p = 0.04), leukocyte levels (p = < 0.01), and thrombocyte levels (p = < 0.01). Multivariate analysis showed leucocyte (p = 0.03) and thrombocyte (p = 0.023) had significantly correlated with DFU severity. Conclusion: Leucocyte and thrombocyte may be the greatest contributing non-vascular factors for severity of DFU in Indonesia. © 2021, Springer Nature Switzerland AG. |
Diabetic foot ulcer; Leucocyte; Non-vascular factor; Thrombocyte |
adult; anemia; Article; clinical feature; controlled study; correlational study; cross-sectional study; diabetic foot; disease association; disease course; disease duration; disease severity; female; forefoot; glycemic control; hemodynamics; human; hypoalbuminemia; Indonesia; leukocyte count; leukocytosis; lipid analysis; major clinical study; male; malnutrition; non insulin dependent diabetes mellitus; peripheral neuropathy; platelet count; tertiary care center |
Springer Science and Business Media Deutschland GmbH |
22516581 |
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Article |
Q2 |
619 |
8164 |
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382 |
Vityadewi N., Bangun K., Budiman, Winarsih W., Fauzi A.R. |
57218771358;36902624600;57222390006;16053776500;57203133889; |
Correction to: Auricular cartilage regeneration on donor site defect with one-sided perichondrial cartilage graft in an experimental rabbit model (European Journal of Plastic Surgery, (2021), 44, 3, (307-314), 10.1007/s00238-020-01765-2) |
2021 |
European Journal of Plastic Surgery |
44 |
3 |
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417 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102563175&doi=10.1007%2fs00238-021-01810-8&partnerID=40&md5=a522ad3fbe4e9f01f86ca4cc71a8915e |
Plastic, Reconstructive, and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia; Plastic, Reconstructive, and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Gatot Subroto Army Hospital, Jakarta, Indonesia; Division of Pathology, Department of Veterinary Clinic Reproduction and Pathology, Bogor Agricultural University, Bogor, 16680, Indonesia |
Vityadewi, N., Plastic, Reconstructive, and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia; Bangun, K., Plastic, Reconstructive, and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, 10430, Indonesia; Budiman, Division of Plastic, Reconstructive, and Aesthetic Surgery, Department of Surgery, Gatot Subroto Army Hospital, Jakarta, Indonesia; Winarsih, W., Division of Pathology, Department of Veterinary Clinic Reproduction and Pathology, Bogor Agricultural University, Bogor, 16680, Indonesia; Fauzi, A.R., Plastic, Reconstructive, and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia |
There is a leak in the name of Kristiania Bangun (The second author), and the correct name is “Kristaninta Bangun”. The original article has been corrected. © 2021, Springer-Verlag GmbH Germany, part of Springer Nature. |
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erratum |
Springer Science and Business Media Deutschland GmbH |
0930343X |
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Erratum |
Q3 |
219 |
18194 |
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388 |
Vityadewi N., Bangun K., Budiman, Winarsih W., Fauzi A.R. |
57218771358;36902624600;57222390006;16053776500;57203133889; |
Auricular cartilage regeneration on donor site defect with one-sided perichondrial cartilage graft in an experimental rabbit model |
2021 |
European Journal of Plastic Surgery |
44 |
3 |
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307 |
314 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099103344&doi=10.1007%2fs00238-020-01765-2&partnerID=40&md5=584c9d67f1904c8e4053cf3ba2855fbe |
Plastic, Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia; Plastic Surgery Reconstruction and Aesthetics Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Division of Plastic Reconstructive Aesthetic Surgery, Department of Surgery, Gatot Subroto Army Hospital, Jakarta, Indonesia; Division of Pathology, Department of Veterinary Clinic Reproduction and Pathology, Bogor Agricultural University, Bogor, 16680, Indonesia |
Vityadewi, N., Plastic, Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia; Bangun, K., Plastic Surgery Reconstruction and Aesthetics Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Budiman, Division of Plastic Reconstructive Aesthetic Surgery, Department of Surgery, Gatot Subroto Army Hospital, Jakarta, Indonesia; Winarsih, W., Division of Pathology, Department of Veterinary Clinic Reproduction and Pathology, Bogor Agricultural University, Bogor, 16680, Indonesia; Fauzi, A.R., Plastic, Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia |
Background: Auricular cartilage is considered the source for cartilage grafts with good esthetic results and is often used in augmentation rhinoplasty. Most revision procedures require grafting, and the auricular cartilage can be the source for secondary rhinoplasty. Due to limited donor locations, donor site optimization of graft material is very important. We aimed to evaluate the healing process from the donor site, including the regeneration of cartilage from the donor site in an experimental animal model. Methods: Six New Zealand white rabbits were used for the investigation of cartilage regeneration from donor defects with one-sided perichondrium. Cartilage defect measuring 0.5 × 3 cm was made in rabbit ears. Two trial groups with 12 ears in each group were formed (one-sided perichondrium vs without perichondrium). Macroscopic and microscopic evaluation examinations were performed at week 4. The gap and thickness of the donor defect were measured with a centimeter grinder for macroscopic evaluation. Results: While macroscopic evaluation of wound thickness and the gap was not significant between groups (p = 1.00, p = 0.053, respectively), microscopic evaluation showed immature cartilage formation at week 4 of the donor defect with one-sided perichondrium (p = 0.004). Conclusions: The donor defect with one-sided perichondrium showed new cartilage formation within the area of the perichondrium. These findings showed the regeneration of cartilage was developed at the donor defects with one-sided perichondrium in the fourth week. Level of evidence: Not ratable. © 2021, Springer-Verlag GmbH Germany, part of Springer Nature. |
Auricular cartilage graft; Cartilage healing; Cartilage regeneration; Donor defect |
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Springer Science and Business Media Deutschland GmbH |
0930343X |
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Article |
Q3 |
219 |
18194 |
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806 |
Adriztina I., Munir D., Sandra F., Ichwan M., Bashiruddin J., Putra I.B., Farhat, Sembiring R.J., Sartika C.R., Chouw A., Pratiwi E.D. |
56928394300;57039203600;56016164200;26040779000;56469338300;57194636376;57194721197;57038845000;57205297509;56431084200;57223858156; |
Differentiation capacity of dental pulp stem cell into inner ear hair cell using an in vitro assay: a preliminary step toward treating sensorineural hearing loss |
2021 |
European Archives of Oto-Rhino-Laryngology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106239040&doi=10.1007%2fs00405-021-06864-9&partnerID=40&md5=5a4ff939b0fff7361593d6d043015bd8 |
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansyur No 5, Medan, Sumatera Utara 20155, Indonesia; Division of Oral Biology, Departement of Biochemistry and Molecular Biology, Faculty of Dentistry, Trisakti University, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Dermatovenerology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Prodia Stemcell Indonesia, Jl. Kramat VII No.11, Jakarta, Indonesia |
Adriztina, I., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansyur No 5, Medan, Sumatera Utara 20155, Indonesia; Munir, D., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansyur No 5, Medan, Sumatera Utara 20155, Indonesia; Sandra, F., Division of Oral Biology, Departement of Biochemistry and Molecular Biology, Faculty of Dentistry, Trisakti University, Jakarta, Indonesia; Ichwan, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Bashiruddin, J., Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Putra, I.B., Department of Dermatovenerology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Farhat, Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Jl. Dr. Mansyur No 5, Medan, Sumatera Utara 20155, Indonesia; Sembiring, R.J., Department of Clinical Pathology, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Sartika, C.R., Prodia Stemcell Indonesia, Jl. Kramat VII No.11, Jakarta, Indonesia; Chouw, A., Prodia Stemcell Indonesia, Jl. Kramat VII No.11, Jakarta, Indonesia; Pratiwi, E.D., Prodia Stemcell Indonesia, Jl. Kramat VII No.11, Jakarta, Indonesia |
Purpose: Sensorineural hearing loss (SNHL) is commonly caused by the death or dysfunction of cochlear cell types as a result of their lack of regenerative capacity. However, regenerative medicine, such as stem cell therapy, has become a promising tool to cure many diseases, including hearing loss. In this study, we determined whether DPSCs could differentiate into cochlear hair cell in vitro. Methods: DPSCs derived from human third molar dental pulp were induced into NSCs using a medium containing basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) for 7 days, and then into cochlear hair cell using a medium containing EGF and IGF-1 for the next 14 days. We used the neuroepithelial protein marker nestin and cochlear hair cell marker myosin VIIa as the markers for cells differentiation. Cells expressing the positive markers under the microscope were confirmed to have differentiated into cochlear hair cell. Results: DPSCs were successfully induced to differentiate into NSCs, with mean 24% nestin-positive cells. We found that DPSC-derived NSCs have a great capacity in differentiating into inner ear hair cell-like cells with an average of 81% cells presenting myosin VIIa. Thus, DPSCs have high potential to serve as a good resource for SNHL treatment. Conclusion: We found the high potential of DPSCs to differentiate into NSC. The ability of DPSCs in differentiating into neural lineage cell made them a good candidate for regenerative therapy in neural diseases, such as SNHL © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
Cochlear hair cell; Dental pulp stem cells; Sensorineural hearing loss |
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Springer Science and Business Media Deutschland GmbH |
09374477 |
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34008035 |
Article |
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849 |
5560 |
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923 |
Hidayati E.L., Utami M.D., Rohsiswatmo R., Tridjaja B. |
57200542624;57217291921;55533574600;6504507193; |
Cystatin C compared to serum creatinine as a marker of acute kidney injury in critically ill neonates |
2021 |
Pediatric Nephrology |
36 |
1 |
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181 |
186 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087002032&doi=10.1007%2fs00467-020-04668-3&partnerID=40&md5=45ca525dfa7a5bd6f6f0c1d995fe7930 |
Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Hidayati, E.L., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Utami, M.D., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rohsiswatmo, R., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Tridjaja, B., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Acute kidney injury (AKI) is one of the most common causes of neonatal morbidity and mortality. Diagnosing AKI in neonates is challenging as it lacks specific signs, symptoms, and biomarkers. However, detecting AKI in critically ill neonates is crucial to determine appropriate management and prevent complications. Cystatin C (CysC) has been recognized as a superior kidney biomarker reflecting kidney function in neonates. The objective of this study is to evaluate the diagnostic value of CysC as an AKI biomarker in critically ill neonates. Methods: We performed a diagnostic test between cystatin C-based estimated glomerular filtration rate (eGFR-CysC) and serum creatinine-based estimated glomerular filtration rate (eGFR-SCr) as the gold standard to diagnose AKI in 135 critically ill neonates treated in Cipto Mangunkusumo National Hospital from July 2017 to January 2018. Results: Prevalence of AKI was 23.7% predominantly in neonates with a very preterm gestational age, low birthweight, probable sepsis, and those receiving invasive oxygen therapy or nephrotoxic drugs. The proportion of AKI based on neonate RIFLE criteria was 72.7% risk, 18.9% injury, and 9% failure. eGFR-CysC had the following parameters: sensitivity, 84.8%; specificity, 61.8%; PPV, 41.8%; NPV, 89.7%; LR(+), 2.2; LR(−), 0.24; and accuracy, 67.4%. The AUROC for CysC was 84.9%. The optimal cut-off value for CysC was 1.605 mg/l. Conclusions: CysC may be used as a screening biomarker of AKI in critically ill neonates; yet, it was not superior to serum creatinine. [Figure not available: see fulltext.]. © 2020, IPNA. |
Acute kidney injury; Critically ill neonates; Cystatin C; Serum creatinine |
creatinine; cystatin C; biological marker; creatinine; cystatin C; epidermal growth factor receptor; acute kidney failure; area under the curve; Article; controlled study; creatinine blood level; critically ill patient; diagnostic accuracy; diagnostic test; diagnostic test accuracy study; diagnostic value; estimated glomerular filtration rate; extremely low birth weight; female; gestational age; human; low birth weight; major clinical study; male; negative likelihood ratio; newborn; oxygen therapy; positive likelihood ratio; predictive value; prematurity; prevalence; priority journal; receiver operating characteristic; sensitivity and specificity; sepsis; very low birth weight; acute kidney failure; critical illness; prospective study; Acute Kidney Injury; Biomarkers; Creatinine; Critical |
Springer Science and Business Media Deutschland GmbH |
0931041X |
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32594242 |
Article |
Q1 |
831 |
5739 |
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