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No records
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665 |
Atmakusuma T.D., Nasution I.R., Sutandyo N. |
57216961785;8259214700;26028099200; |
Oxidative stress (Malondialdehyde) in adults beta-thalassemia major and intermedia: Comparison between before and after blood transfusion and its correlation with iron overload |
2021 |
International Journal of General Medicine |
14 |
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6455 |
6462 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119614825&doi=10.2147%2fIJGM.S336805&partnerID=40&md5=31da8ca15b655debd14557088a36df4a |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, Gatot Soebroto Army Hospital Jakarta/Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, Dharmais National Cancer Hospital Jakarta/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Nasution, I.R., Division of Hematology-Medical Oncology, Department of Internal Medicine, Gatot Soebroto Army Hospital Jakarta/Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sutandyo, N., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dharmais National Cancer Hospital Jakarta/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Iron overload is a major problem in both transfusion-dependent (TDT) and non-transfusion-dependent thalassemia (NTDT). It has been known to increase oxidative stress. Meanwhile, blood transfusion as main therapy for thalassemia increases iron overload. One of the markers of oxidative stress is malondialdehyde (MDA). This study aims to provide data on MDA levels in adult thalassemia patients, and to compare the levels before and after transfusion in patients with TDT and NTDT. Methods: This is a cross-sectional, pre-post study in adult patients with thalassemia major and intermedia that received blood transfusion with or without iron-chelating agents in Cipto Mangunkusumo Hospital. Blood samples were taken immediately before the transfusion and one day after. Serum ferritin (SF) assays were conducted by electrochemiluminescence immunoassay method, while transferrin saturation (TS) was calculated by dividing serum iron by the binding capacity. Subsequently, plasma MDA levels assays were performed using the Wills method, and data analysis was conducted using the t-test/Mann–Whitney and Pearson/Spearman correlation test, depending on the data distribution. Results: The 63 respondents recruited consist of 51 TDT and 12 NTDT patients, and their median plasma MDA level before and after transfusion was 0.49 µmol/L and 0.45 µmol/L, respectively. Before transfusion, there was no correlation between SF and MDA, and TS and MDA levels. After the transfusion, there was no correlation between, SF and MDA, or TS and MDA levels. Conclusion: There is no significant difference in MDA levels before and after transfusion. Although blood transfusion increases the iron load in thalassemia patients, there was no increase in median MDA level after transfusion. Meanwhile, there was no correlation between markers of iron overload and MDA level in thalassemia patients both before and after transfusion. © 2021 Atmakusuma et al. This work is published and licensed by Dove Medical Press Limited. |
Iron overload; Malondialdehyde; Non-transfusion dependent thalassemia; Oxidative stress; Transfusion-dependent thalassemia |
deferasirox; deferiprone; deferoxamine; ferritin; malonaldehyde; adult; aged; Article; blood transfusion; controlled study; cross-sectional study; female; ferritin blood level; hemoglobin E-beta thalassemia; human; Indonesia; iron chelation; iron overload; major clinical study; male; non transfusion dependent thalassemia; oxidative stress; thalassemia major; transferrin saturation; transfusion dependent thalassemia |
Dove Medical Press Ltd |
11787074 |
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Article |
Q2 |
722 |
6874 |
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684 |
Sukrisman L., Sinto R., Priantono D. |
8661764000;36099377100;57219443427; |
Hematologic profiles and correlation between absolute lymphocyte count and neutrophil/ lymphocyte ratio with markers of inflammation of covid-19 in an indonesian national referral hospital |
2021 |
International Journal of General Medicine |
14 |
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6919 |
6924 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117751905&doi=10.2147%2fIJGM.S337440&partnerID=40&md5=3dd70fba2ee4c7395a09b7807a9e5c42 |
Division of Haematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Tropical and Infectious Disease, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Sukrisman, L., Division of Haematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sinto, R., Division of Tropical and Infectious Disease, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Priantono, D., Division of Haematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: COVID-19 is a pandemic with significant mortality and it is important to differentiate severe and non-severe cases. We conducted a study to evaluate hematologic profiles with inflammation markers in COVID-19 patients and to determine the correlation of neutrophil-lymphocyte ratio (NLR) with disease severity. Methods: A cross-sectional study involving hospitalized COVID-19 patients confirmed with a positive SARS-CoV-2 PCR test in Dr. Cipto Mangunkusumo Hospital. Lymphocyte count, NLR, C-reactive protein (CRP) and ferritin were evaluated in severe and non-severe COVID-19 cases at hospital admission. Data was analyzed using Spearman correlation. Results: There were 41 patients aged 20 to 79 years with COVID-19; 33 (80.5%) were nonsevere, and 8 (19.5%) were severe cases. There is a statistically significant difference in WBC, relative neutrophils and lymphocytes, NLR, and CRP between non-severe and severe cases. There is a strong correlation between NLR and CRP (r = 0.738; p < 0.001). Our findings show that NLR and absolute lymphocyte count, but not ferritin, play a role in differentiating between non-severe and severe COVID-19 cases. Conclusion: In COVID-19 cases, a strong correlation between NLR and CRP might suggest the use of NLR to differentiate between non-severe and severe cases, especially in a remote healthcare facility. © 2021 Sukrisman et al. This work is published and licensed by Dove Medical Press Limited. |
COVID-19; Hematologic profiles; Inflammation; Lymphocyte; NLR |
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Dove Medical Press Ltd |
11787074 |
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Article |
Q2 |
722 |
6874 |
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No records
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191 |
Wahdini S., Putra V.P., Sungkar S. |
57203684068;57299060700;57016857300; |
The prevalence of intestinal protozoan infections among children in southwest sumba based on the type of water sources |
2021 |
Infection and Chemotherapy |
53 |
3 |
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519 |
527 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117295741&doi=10.3947%2fic.2021.0067&partnerID=40&md5=f72157a8065763eba10ce0eed22c987b |
Department of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Wahdini, S., Department of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Putra, V.P., Department of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sungkar, S., Department of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Intestinal protozoan infection is a public health problem in Indonesia, particularly in regions lacking clean water sources such as Perokonda and Perobatang villages, Southwest Sumba Regency, East Nusa Tenggara Province. The residents of Perokonda and Perobatang villages use wells and unprotected open springs respectively. Therefore, this study aims to determine the prevalence of intestinal protozoan infections in these two villages. Materials and Methods: This was a cross-sectional study, carried out in Perokonda and Perobatang from August 2016 to August 2017. A total of 291 children aged 6 months to 18 years were used as subjects. Furthermore, fecal examinations were carried out by preparing smears, which were stained with lugol solution and examined under the microscopes by four experienced technicians. The data were processed using SPSS version 20 and analyzed by chi-square test. Results: Among the 291 samples, the prevalence of intestinal protozoan infections was 20%, with 23.4% in Perokonda and 17.2% in Perobatang. The predominant species found were Blastocystis hominis (34.5%), Giardia lamblia (19.0%), and Entamoeba coli (15.5%). Moreover, approximately 69.0% of single infections were found while 31.0% were mixed and associated with 2 to 3 protozoan species. There were no significant differences between the prevalence of intestinal protozoan infections and the children in Perokonda and Perobatang villages (confidence interval 0.83 - 2.62, P = 0.19). Conclusion: The type of water sources has no relationship with the species of intestinal protozoan infecting children in Perokonda and Perobatang. © 2021 Korean Society for Antimicrobial Therapy. All rights reserved. |
Children 6 months to 18 years old; Intestinal protozoan; Southwest Sumba; Water sources |
adolescent; adult; Article; Blastocystis hominis; child; controlled study; cross-sectional study; Entamoeba coli; feces analysis; female; Giardia intestinalis; human; infant; intestine infection; major clinical study; male; pediatric patient; prevalence; protozoal infection; water supply |
Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, Korean Society for AIDS |
20932340 |
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Article |
Q2 |
724 |
6845 |
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526 |
Pudjiadi A.H., Antonjaya U., Myint K.S., Alatas F.S. |
18435202300;36016109600;7003758970;57217150164; |
Echovirus-7 infection in children with unusual severe manifestation: A case report |
2021 |
Infection and Chemotherapy |
53 |
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141 |
145 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104262436&doi=10.3947%2fIC.2020.0081&partnerID=40&md5=80e71bfc568af5c4cf2736e907d992fe |
Department of Child-Health, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Eijkman Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Emerging Virus Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Pudjiadi, A.H., Department of Child-Health, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Antonjaya, U., Eijkman Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Myint, K.S., Emerging Virus Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Alatas, F.S., Department of Child-Health, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
We report a rare laboratory-confirmed, clinical case of Echovirus-7 infection in an immunocompetent child with central nervous system and systemic manifestation. Echovirus infection is usually mild, however in this case we identified echovirus-7 infection with 91% homology with the Echovirus-7 strain previously isolated in neighbouring country with severe manifestation. Copyright © 2021 by The Korean Society of Infectious Diseases, |
Echovirus-7; Encephalitis; Enterovirus; QRT-PCR; Sepsis |
cephalosporin; phenobarbital; procalcitonin; thromboplastin; valproic acid; Article; blood gas analysis; breathing rate; case report; cerebrospinal fluid; childhood disease; clinical article; differential diagnosis; digestive system injury; disease severity; disseminated intravascular clotting; echovirus 7 infection; Echovirus infection; ego development; emergency ward; family history; fever; Glasgow coma scale; heart rate; hemoglobin blood level; hospital admission; hospitalization; human; hypokalemia; infant; laboratory test; leukopenia; lung auscultation; male; nose smear; nucleotide sequence; physical examination; platelet count; prothrombin time; Pseudomonas aeruginosa; real time reverse transcription polymerase chain reaction; rectal swab; rectal temperature; seizure; sepsis; sputum |
Korean Society of Infectious Diseases, Korean Society for Antimicrobial Therapy, Korean Society for AIDS |
20932340 |
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Article |
Q2 |
724 |
6845 |
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No records
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71 |
Tandaju J.R., Li W., Pateras K., Georgiopoulos G. |
57222662533;57369633600;57200224369;57188877741; |
Deriving cut-off values for continuous predictors of severe outcomes in COVID-19 through meta-analysis of individual studies |
2021 |
American Journal of Emergency Medicine |
50 |
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799 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104938971&doi=10.1016%2fj.ajem.2021.03.029&partnerID=40&md5=b4a3015c95a454387a73134ab5845aa6 |
Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia; The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Department of Biostatistics and Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom; Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athen, Greece |
Tandaju, J.R., Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia; Li, W., The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Pateras, K., Department of Biostatistics and Research Support, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Georgiopoulos, G., School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athen, Greece |
[No abstract available] |
|
clinical outcome; coronavirus disease 2019; disease severity; human; Letter; COVID-19; Humans; SARS-CoV-2 |
W.B. Saunders |
07356757 |
|
33958246 |
Letter |
Q1 |
725 |
6828 |
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271 |
Yonas E., Alwi I., Pranata R., Huang I., Lim M.A., Gutierrez E.J., Yamin M., Siswanto B.B., Virani S.S. |
57201987097;15055173800;57201973901;57208576645;57216039756;57200435964;23475706300;14422648800;6701757915; |
Effect of heart failure on the outcome of COVID-19 — A meta analysis and systematic review |
2021 |
American Journal of Emergency Medicine |
46 |
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204 |
211 |
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43 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090893264&doi=10.1016%2fj.ajem.2020.07.009&partnerID=40&md5=08c8139ca7f811f915c445cf5c2e3f1c |
Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Department of Critical Care Medicine, Baptist Medical Center, Jacksonville, FL, United States; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Michael E. DeBakey Veterans Affairs Medical Center & Baylor College of Medicine, Houston, TX, United States; Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia |
Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Alwi, I., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Huang, I., Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Gutierrez, E.J., Department of Critical Care Medicine, Baptist Medical Center, Jacksonville, FL, United States; Yamin, M., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siswanto, B.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Virani, S.S., Michael E. DeBakey Veterans Affairs Medical Center & Baylor College of Medicine, Houston, TX, United States |
Background: Several comorbidities have been associated with an increased risk of severity and mortality in coronavirus disease 2019 (COVID-19), including hypertension, diabetes, cerebrovascular disease, chronic kidney disease, and chronic obstructive pulmonary disease. Purpose: In this systematic review and meta-analysis, we attempted to investigate the association between heart failure (HF) and poor outcome in patients with COVID-19. Methods: We performed a systematic literature search from PubMed, EuropePMC, SCOPUS, Cochrane Central Database, and medRxiv with the search terms, “Heart failure” and “COVID-19”. The outcome of interest was mortality and poor prognosis (defined by incidence of severe COVID-19 infection, admission to ICU, and use of ventilator) in patients with preexisting heart failure with coronavirus disease. Results: We identified 204 potential articles from our search, and 22 duplicates were removed. After screening of the titles and abstracts of the remaining 182 articles we identified 92 potentially relevant articles. We excluded 74 studies due to the following reasons: four studies were systematic reviews, two studies were meta-analyses, three articles were literature reviews, and 65 articles did not report on the outcome of interest. Finally, we included the remaining 18 studies in our qualitative synthesis and meta-analysis. There were 21,640 patients from 18 studies. HF was associated with hospitalization in COVID19 HR was 2.37 [1.48, 3.79; p < 0.001], high heterogeneity [I2, 82%; p < 0.001]. HF was associated with a poor outcome demonstrated by an OR of 2.86 [2.07; 3.95; p < 0.001] high heterogeneity [I2, 80%; p < 0.001]. Patient with preexisting HF was associated with higher mortality OR of 3.46 [2.52, 4.75; p < 0.001] moderately high heterogeneity [I2, 77%; p < 0.001]. Conclusion: Patients with heart failure are at increased risk for hospitalization, poor outcome, and death from COVID-19. A significant difference in mortality between patients with and without heart failure was observed, patients with heart failure having a higher mortality. © 2020 Elsevier Inc. |
Coronavirus disease 2019; Heart failure; Poor outcomes |
apnea hypopnea index; Article; artificial ventilation; coronavirus disease 2019; heart failure; hospitalization; human; incidence; meta analysis; mortality; outcome assessment; prevalence; prognosis; questionnaire; risk factor; systematic review; comorbidity; global health; heart failure; pandemic; procedures; risk assessment; survival rate; Comorbidity; COVID-19; Global Health; Heart Failure; Humans; Pandemics; Risk Assessment; Risk Factors; SARS-CoV-2; Survival Rate |
W.B. Saunders |
07356757 |
|
33071085 |
Article |
Q1 |
725 |
6828 |
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485 |
Simadibrata D.M., Calvin J., Wijaya A.D., Ibrahim N.A.A. |
57202134322;57221411392;57221411463;57221410260; |
Neutrophil-to-lymphocyte ratio on admission to predict the severity and mortality of COVID-19 patients: A meta-analysis |
2021 |
American Journal of Emergency Medicine |
42 |
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60 |
69 |
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22 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099401846&doi=10.1016%2fj.ajem.2021.01.006&partnerID=40&md5=9764e041c3a47b836e3ffc766efdf406 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Simadibrata, D.M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Calvin, J., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wijaya, A.D., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ibrahim, N.A.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: The neutrophil-to-lymphocyte ratio (NLR), an inflammatory marker, was suggested to be predictive of severity and mortality in COVID-19 patients. Here, we investigated whether NLR levels on admission could predict the severity and mortality of COVID-19 patients. Methods: A literature search was conducted on 23 July 2020 to retrieve all published articles, including grey literature and preprints, investigating the association between on-admission NLR values and severity or mortality in COVID-19 patients. A meta-analysis was performed to determine the overall standardized mean difference (SMD) in NLR values and the pooled risk ratio (RR) for severity and mortality with the 95% Confidence Interval (95%CI). Results: A total of 38 articles, including 5699 patients with severity outcomes and 6033 patients with mortality outcomes, were included. The meta-analysis showed that severe and non-survivors of COVID-19 had higher on-admission NLR levels than non-severe and survivors (SMD 0.88; 95%CI 0.72–1.04; I2 = 75.52% and 1.87; 95%CI 1.25–2.49; I2 = 97.81%, respectively). Regardless of the different NLR cut-off values, the pooled mortality RR in patients with elevated vs. normal NLR levels was 2.74 (95%CI 0.98–7.66). Conclusion: High NLR levels on admission were associated with severe COVID-19 and mortality. Further studies need to focus on determining the optimal cut-off value for NLR before clinical use. © 2021 Elsevier Inc. |
COVID-19; Meta-analysis; Mortality; Neutrophil-to-lymphocyte ratio; Severity |
Article; coronavirus disease 2019; disease association; disease severity; hospital admission; human; meta analysis; mortality; mortality risk; neutrophil lymphocyte ratio; outcome assessment; prediction; priority journal; quality control; risk assessment; sensitivity and specificity; sex ratio; survivor; systematic review; blood; diagnosis; hospitalization; lymphocyte count; neutrophil; severity of illness index; survival rate; COVID-19; Hospitalization; Humans; Lymphocyte Count; Neutrophils; Severity of Illness Index; Survival Rate |
W.B. Saunders |
07356757 |
|
33453617 |
Article |
Q1 |
725 |
6828 |
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489 |
Pranata R., Tondas A.E., Huang I., Lim M.A., Siswanto B.B., Meyer M., Mitrovic V. |
57201973901;57211111907;57208576645;57216039756;14422648800;57217373886;36008843300; |
Potential role of telemedicine in solving ST-segment elevation dilemmas in remote areas during the COVID-19 pandemic |
2021 |
American Journal of Emergency Medicine |
42 |
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242 |
243 |
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10 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086651966&doi=10.1016%2fj.ajem.2020.06.012&partnerID=40&md5=c3d261a0e2fe3a8f2757142babbe0759 |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Department of Cardiology and Vascular Medicine, Mohammad Hoesin General Hospital, Palembang, Sumatera Selatan, Indonesia; Biomedicine Doctoral Program, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas, Jakarta, Indonesia; Department of Cardiology, Kerckhoff-Klinik, Bad Nauheim, Germany |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Tondas, A.E., Department of Cardiology and Vascular Medicine, Mohammad Hoesin General Hospital, Palembang, Sumatera Selatan, Indonesia, Biomedicine Doctoral Program, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; Huang, I., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Siswanto, B.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Meyer, M., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas, Jakarta, Indonesia; Mitrovic, V., Department of Cardiology, Kerckhoff-Klinik, Bad Nauheim, Germany |
[No abstract available] |
|
troponin; acute coronary syndrome; blood clot lysis; cardiologist; cardiovascular risk; coronavirus disease 2019; echocardiography; electrocardiography; heart ventricle wall motion; human; incidence; Letter; myocarditis; pandemic; practice guideline; priority journal; risk factor; ST segment elevation; ST segment elevation myocardial infarction; takotsubo cardiomyopathy; telecardiology; telemedicine; epidemiology; health care delivery; organization and management; prevention and control; rural health care; ST segment elevation myocardial infarction; telemedicine; COVID-19; Health Services Accessibility; Humans; Rural Health Services; ST Elevation Myocardial Infarction; Telemedicine |
W.B. Saunders |
07356757 |
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32561139 |
Letter |
Q1 |
725 |
6828 |
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No records
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261 |
Pravian D., Soesanto A.M., Ambari A.M., Kuncoro B.R.M.A.S., Dwiputra B., Muliawan H.S., Sukmawan R. |
57223935749;56374199000;57189576921;57223920990;57195383994;57203644653;8651025300; |
The effect of external counterpulsation on intrinsic myocardial function evaluated by speckle tracking echocardiography in refractory angina patients: a randomized controlled trial |
2021 |
International Journal of Cardiovascular Imaging |
37 |
8 |
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2483 |
2490 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106531230&doi=10.1007%2fs10554-021-02289-x&partnerID=40&md5=205259fb7afb6a50c7b9b375ac603918 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Pravian, D., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Soesanto, A.M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Ambari, A.M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Kuncoro, B.R.M.A.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Dwiputra, B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Muliawan, H.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Sukmawan, R., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
External Counterpulsation (ECP) is one of the therapeutic options in patients with refractory angina inadequately controlled by medical, interventional, or surgical therapy. The 2D Speckle Tracking Echocardiography (2D-STE) method is considered superior in assessing clinical improvement. We would like to evaluate any improvement of myocardial intrinsic function using 2D-STE in patients underwent standard ECP protocol (35 sessions). We conducted a double-blind randomized controlled trial. Patients with refractory angina who could not be revascularized conventionally were randomized into two groups: (1) the ECP group (300 mmHg) and (2) the Sham/control group (75 mmHg). ECP standard therapy was given for 35 sessions (1 h/day/session). The 2D-STE data, including longitudinal strain and post systolic index (PSI) were obtained before and after therapy. 43 subjects were analyzed, with 22 subjects in ECP group and 21 control subjects (Sham group). A homogenous baseline strain was found either globally (12.42 ± 4.55 vs 12.00 ± 4.92 [− %]; P = 0.774) or segmentally/regionally (12.63 (0.01–25.16) vs 12.43 (0.01–27.20) [− %]; P = 0.570). There was no statistically significant improvement between groups in the left ventricle longitudinal strain globally (P = 0.535) and segmentally/regionally (P = 0.434). PSI parameters showed improvement in the ECP group (P = 0.049), and segments with PSI ≥ 20% seemed to improve longitudinal strains in the ECP group after therapy (P = 0.042). In conclusion, 35 ECP therapy sessions did not improve either global or segmental/regional left ventricular mechanical function in patients with refractory angina. However, the mechanical function of myocardial segments with PSS tends to improve after ECP therapy. © 2021, The Author(s), under exclusive licence to Springer Nature B.V. |
2D speckle tracking echocardiography; External counterpulsation; Post systolic index; Refractory angina; Strain |
adult; aged; angina pectoris; Article; cardiovascular parameters; clinical article; clinical outcome; controlled study; counterpulsation; double blind procedure; female; follow up; heart function; heart left ventricle enddiastolic diameter; heart left ventricle endsystolic diameter; human; left ventricular global longitudinal strain; male; middle aged; post systolic index; post systolic shortening; randomized controlled trial; tricuspid annular plane systolic excursion; two dimensional speckle tracking echocardiography |
Springer Science and Business Media B.V. |
15695794 |
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34037889 |
Article |
Q2 |
726 |
6821 |
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No records
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95 |
Laksmita Y.A., Sidik M., Siregar N.C., Nusanti S. |
57209279067;57257519600;6508087790;57189727162; |
Neuroprotective Effects of Citicoline on Methanol-Intoxicated Retina Model in Rats |
2021 |
Journal of Ocular Pharmacology and Therapeutics |
37 |
9 |
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534 |
541 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120545903&doi=10.1089%2fjop.2021.0018&partnerID=40&md5=cfe07289839f2866220d3438db7fac57 |
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia; Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Laksmita, Y.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia; Sidik, M., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia; Siregar, N.C., Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nusanti, S., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jl. Sapta No. 40A, Menteng Dalam, Tebet, Jakarta, 12870, Indonesia |
Purpose: This study aims to evaluate the effect of citicoline administration in suppressing retinal damage due to methanol intoxication. This study hypothesizes that citicoline will minimize the loss of retinal ganglion cells (RGCs), minimize disruption of photoreceptors, suppress ganglion layer edema, increase expression of bcl-2 as the antiapoptotic protein, and decrease expression of caspase-3 as the proapoptotic protein. Methods: Fifteen Sprague-Dawley rats were divided into 5 groups, including the control group (A); methanol groups, observed on day 3 (B1) and day 7 (B2); and methanol+citicoline groups, observed on day 3 (C1) and day 7 (C2). Rats in groups B and C were placed in an inhalation chamber filled with N2O:O2 during the experiment, then methanol was administered orally. Citicoline, 1 g/kg every 24 h, was orally administered for group C. Enucleation was performed and retinas of rats were prepared for histology and immunohistochemistry examination to evaluate photoreceptor morphology and RGC density, as well as bcl-2 and caspase-3 expression. Results: RGC density of citicoline-treated intoxicated rats was higher than no-citicoline methanol-intoxicated rats on both day 3 (P < 0.001) and day 7 (P < 0.001). The ganglion layer thickness of citicoline-treated intoxicated rats was thinner than no-citicoline intoxicated rats, which means citicoline-treated rats had milder ganglion layer edema. Citicoline-treated rats showed higher bcl-2 and lower caspase-3 expression than no-citicoline rats. No differences were found in photoreceptor findings among groups. Conclusions: This study demonstrated citicoline's potential benefits for management of ocular methanol intoxication. However, more preclinical and clinical trials are needed to obtain a preferred dosage and timing of citicoline administration. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
citicoline; methanol intoxication; methanol optic neuropathy; neuroprotector; retina; toxic optic neuropathy |
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Mary Ann Liebert Inc. |
10807683 |
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34495749 |
Article |
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727 |
6812 |
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