Funding text 1: This research was funded in part by the Wellcome Trust [ 220211 ], National Natural Science Foundation of China [ 42201497 ], Youth Innovation Promotion Association [ 2023000117 ], and NRF International Partnership Funding Initiative [ RIE2025 ]. The funder had no role in study design, data collection, data analysis, data interpretation, or writing of this study. ; Funding text 2: