Publikasi Scopus 2024 per tanggal 30 September 2024 (820 artikel)

Sari T.T.; Wahidiyat P.A.; Rahmartani L.D.; Iskandar S.D.; Putri I.A.
Sari, Teny Tjitra (36519483600); Wahidiyat, Pustika Amalia (24400464000); Rahmartani, Ludi Dhyani (57210445114); Iskandar, Stephen Diah (57195197654); Putri, Isyanaditta Agung (57554243500)
36519483600; 24400464000; 57210445114; 57195197654; 57554243500
Comparison of Yearly Cost Related to Complications Between Deferasirox and Deferiprone Monotherapy in Thalassemia
2024
Journal of Pediatric Hematology/Oncology
46
6
e402
e405
3
0
Department of Pediatrics Hematology-Oncology, Cipto Faculty of Medicine, Universit/Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
Sari T.T., Department of Pediatrics Hematology-Oncology, Cipto Faculty of Medicine, Universit/Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Wahidiyat P.A., Department of Pediatrics Hematology-Oncology, Cipto Faculty of Medicine, Universit/Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Rahmartani L.D., Department of Pediatrics Hematology-Oncology, Cipto Faculty of Medicine, Universit/Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Iskandar S.D., Department of Pediatrics Hematology-Oncology, Cipto Faculty of Medicine, Universit/Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Putri I.A., Department of Pediatrics Hematology-Oncology, Cipto Faculty of Medicine, Universit/Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
Background: Hemoglobin disorders such as thalassemia major have created an economic burden on the health care system. Iron chelation therapy (ICT) is the most expensive cost component in patients with thalassemia. ICT was administered to reduce the toxic effects of iron overload. This study aims to compare the costs of iron chelators as monotherapy in patients with thalassemia major in Indonesia, specifically in Cipto Faculty of Medicine, Universit. Methods: This is a retrospective analytical observational study. Data were collected from the thalassemia registry from 2016 to 2019. Patients' age, gender, type of thalassemia, and type of iron chelation were recorded. Complications and total annual costs were evaluated. All thalassemia patients aged ≥2 years who were only receiving monotherapy ICT and had no history of therapy switching were eligible. We excluded subjects who moved out to other facilities or lost to follow-up. Results: From a total of 256 subjects, 249 subjects were included. The median age is 28 years old. Both sexes were represented equally. As many as 96.8% of subjects have thalassemia beta. Deferiprone was the most common iron chelator used (86.7%). Complications were observed in the subjects based on 4-year data collection; most of them were cardiomyopathy, diabetes mellitus, delayed puberty, and malnutrition (P=0.422; P=0.867; P=0.004; and P=0.125, respectively). Deferiprone had a lower mean annual cost of USD 3581 than deferasirox, which had a cost of USD 6004. Conclusions: Cardiomyopathy, diabetes mellitus, delayed puberty, and malnutrition were the most common complications found in the study. This study showed that deferiprone should be taken as consideration as a drug of choice to treat iron overload in thalassemia provided by Indonesian national health insurance which is less costly despite the probability of complications found after the treatment was given. Further investigations are required to evaluate contributing factors of complications in thalassemia. Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.
cost-effectiveness; deferasirox; deferiprone; iron chelating agent; iron overload; thalassemia major
Adolescent; Adult; beta-Thalassemia; Chelation Therapy; Child; Child, Preschool; Deferasirox; Deferiprone; Female; Humans; Indonesia; Iron Chelating Agents; Iron Overload; Male; Retrospective Studies; Thalassemia; Young Adult; albumin; alkaline phosphatase; bilirubin; calcium; deferasirox; deferiprone; estradiol; ferritin; follitropin; iron chelating agent; luteinizing hormone; phosphate; testosterone; thyrotropin; thyroxine; transferrin; deferasirox; deferiprone; iron chelating agent; activated partial thromboplastin time; adult; Article; audiometry; beta thalassemia; bone density; cardiomyopathy; child; delayed puberty; diabetes mellitus; drug cost; echocardiography; electrocardiography; female; follow up; glucose blood level; growth disorder; health insurance; hormonal therapy; hospital
Universitas Indonesia, UI
This study was funded by Universitas Indonesia.
Lippincott Williams and Wilkins
10774114
38832436
Article
Q3
328
14890