Publikasi Scopus 2024 per tanggal 30 September 2024 (820 artikel)

Cahyanur R.; Widhani A.; Pantoro N.; Madadika A.T.
Cahyanur, Rahmat (37066991400); Widhani, Alvina (57202561455); Pantoro, Nico (57372295200); Madadika, Annisa Tsana (59286714400)
37066991400; 57202561455; 57372295200; 59286714400
Association between immune system parameter and clinical characteristics among patients with solid cancer
2024
Medical Journal of Indonesia
33
2
93
97
4
0
Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Cahyanur R., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Widhani A., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pantoro N., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Madadika A.T., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia
BACKGROUND Lymphopenia has been reported to be a major predictor of chemotherapy-related toxicity. This study aimed to investigate the correlation between neutrophils, lymphocytes, CD4, and CD8 in solid cancer patients and cancer clinical characteristics. METHODS This was a cross-sectional study of patients who will undergo chemotherapy at the Hematology and Medical Oncology Clinic, Cipto Mangunkusumo Hospital, from June to September 2023. Clinical characteristics, CD4 and CD8 levels, and neutrophil and lymphocyte counts were assessed at the first visit. A comparative test was carried out on the patients’ average CD4, CD8, neutrophil, and lymphocyte counts. RESULTS Types of cancer were associated with CD4 levels. Patients with head and neck cancer had lower CD4 levels (411.3 [119.3–1,427.5] cells/mm³) compared with colorectal (514.7 [129.2–861.3] cells/mm³), breast and gynecological (567.5 [180.1–939 cells/mm³), and other cancers (681.4 [175.1–2,056.9] cells/mm³), with p = 0.009. Patients aged ≥40 years had higher CD8 levels than those aged <40 years (376.4 [142.8–1,293.1] cells/mm³ versus 565.3 [185.9–1,944] cells/mm³, p = 0.01). Additionally, lymphocyte count was associated with cancer type, with the lowest number in head and neck cancer (1,380 [280–2,660] μl, p = 0.044). CONCLUSIONS CD4 levels and lymphocyte counts were associated with the cancer type, whereas CD8 levels were influenced by age. © 2024 Authors.
malignancy; S CD4 lymphocyte count
interleukin 2; interleukin 4; adult; Article; blood sampling; body mass; cancer staging; CD4+ T lymphocyte; CD8+ T lymphocyte; chemotherapy; controlled study; cross-sectional study; cytometry; female; head and neck cancer; hospital patient; human; immune system; immunosenescence; immunosuppressive treatment; lymphocyte count; lymphocytopenia; major clinical study; male; malignant neoplasm; middle aged; natural killer cell; neutrophil count; obesity; professional standard; thymus function; toxicity
Publikasi Terindeks Internasional; Universitas Indonesia, UI, (NKB-199/UN2.RST/HKP.05.00/2022)
Funding text 1: This study was funded by the Publikasi Terindeks Internasional; Funding text 2: (PUTI) Prosiding Grant 2022 from Universitas Indonesia (Contract Number NKB-199/UN2.RST/HKP.05.00/2022).
Faculty of Medicine, Universitas Indonesia
08531773
Article
Q4
172
21638