Publikasi Scopus 2024 per tanggal 30 September 2024 (820 artikel)

Hair T.A.; Hadisaputra W.; Soebijanto S.; Rustamadji P.
Hair, Tanzil Al (59309646800); Hadisaputra, Wachyu (6602393903); Soebijanto, Soegiharto (57192904676); Rustamadji, Primariadewi (55321572200)
59309646800; 6602393903; 57192904676; 55321572200
Apoptotic Pathways and Anti-Müllerian Hormone affects the Ovarian Tissue Damage during Endometrioma Cystectomy
2024
Journal of Angiotherapy
8
5
9690
0
Department Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Anatomical Pathology, Faculty of Medicine Universitas, Indonesia
Hair T.A., Department Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia; Hadisaputra W., Department of Anatomical Pathology, Faculty of Medicine Universitas, Indonesia; Soebijanto S., Department of Anatomical Pathology, Faculty of Medicine Universitas, Indonesia; Rustamadji P., Department of Anatomical Pathology, Faculty of Medicine Universitas, Indonesia
Background: Endometriomas are cysts caused by endometriosis that can impair ovarian function and fertility. Anti-Müllerian hormone (AMH) is an important marker for ovarian reserve. This study aimed to determine the optimal timing of operative management for endometrioma by evaluating the impact of cyst size on ovarian tissue damage and hormone levels. Methods: The study included 32 endometrioma patients who underwent laparoscopic cystectomy between February 2018 and December 2019 at Women and Children’s YPK Hospital, Jakarta. Patient characteristics were recorded, including age, parity, BMI, and cyst diameter. Serum AMH levels were measured using ELISA before and one month after cystectomy. Immunohistochemical examination assessed apoptotic factor gene expression on the inner surface epithelium of endometriomas. Results: AMH levels declined post-cystectomy in both endometriomas ≤4 cm and >4 cm, with significant differences in the latter group. Additionally, there was increased Bax expression in >4 cm endometriomas. Correlation tests revealed a strong positive relationship between TNFR1 and Caspase-3 in both groups. Multivariate analysis suggested a connection between apoptotic factor gene expression and reduced AMH levels. Conclusion: TNF-α appears to initiate apoptosis in endometriomas through the intrinsic pathway. It is advisable to perform endometrioma surgery when the diameter is ≤4 cm and before the age of 30 to achieve optimal outcomes. © 2024, Eman Research. All rights reserved.
AMH; apoptosis; Bcl-2/Bax ratio; caspase-3; caspase-8; caspase-9; cytokine TNF-α; endometrioma; gene expression; intrinsic pathway; P53
Eman Research
22078843
Article
Q4
106
27095