Publikasi Scopus 2024 per tanggal 30 September 2024 (820 artikel)

Aisyi M.; Andriastuti M.; Kosasih A.S.; Utomo A.R.H.; Saputra F.; Sari T.T.; Sjakti H.A.; Dwijayanti F.; Harimurti K.; Gatot D.
Aisyi, Mururul (57211112533); Andriastuti, Murti (57191058317); Kosasih, Agus Susanto (55879389300); Utomo, Ahmad Rusdan Handoyo (15046121800); Saputra, Fahreza (57214091714); Sari, Teny Tjitra (36519483600); Sjakti, Hikari Ambara (57195720458); Dwijayanti, Fifi (57214674955); Harimurti, Kuntjoro (23473513200); Gatot, Djajadiman (6508292159)
57211112533; 57191058317; 55879389300; 15046121800; 57214091714; 36519483600; 57195720458; 57214674955; 23473513200; 6508292159
Unraveling Copy Number Alterations in Pediatric B-Cell Acute Lymphoblastic Leukemia: Correlation with Induction Phase Remission Using MLPA
2024
Asian Pacific Journal of Cancer Prevention
25
7
2421
2426
5
0
Department of Pediatric Hematology-Oncology, Dharmais Cancer Center Hospital, Letjen S Parman Street Kav 84–86, Jakarta, 11420, Indonesia; Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Dharmais Cancer Hospital, Jakarta, Indonesia; Graduate School of Biomedical Science, Universitas YARSI, Jakarta, Indonesia; Research and Development Department, Dharmais National Cancer Center Hospital, Jakarta, Indonesia; Department of Research and Development, Dharmais National Cancer Hospital, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Aisyi M., Department of Pediatric Hematology-Oncology, Dharmais Cancer Center Hospital, Letjen S Parman Street Kav 84–86, Jakarta, 11420, Indonesia; Andriastuti M., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kosasih A.S., Department of Clinical Pathology, Dharmais Cancer Hospital, Jakarta, Indonesia; Utomo A.R.H., Graduate School of Biomedical Science, Universitas YARSI, Jakarta, Indonesia; Saputra F., Research and Development Department, Dharmais National Cancer Center Hospital, Jakarta, Indonesia; Sari T.T., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sjakti H.A., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Dwijayanti F., Department of Research and Development, Dharmais National Cancer Hospital, Jakarta, Indonesia; Harimurti K., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gatot D., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Objective: Acute Lymphoblastic Leukemia (ALL) is the most common malignancy occurring in children. Copy number alterations (CNA) like PAX5, CDKN2A/2B, PAR1 Region, ETV6, IKZF1, BTG1, and RB1 gene deletion are important genetic events that define and prognosticate B-cell ALL. Thus, this study aimed to evaluate associations of CNA with induction phase remission status in childhood B-cell ALL. Methods: This study was observational with a cross-sectional design at the Dharmais Cancer Hospital, Harapan Kita Mother and Children Hospital, and Tangerang Regional Public Hospital. We evaluated 74 pediatric B-cell ALL cases with 1–18-year-olds. Genomic DNA was analyzed by Multiplex Ligation Dependent Probe Amplification Assay (MLPA). This study used the P335 ALL-IKZF1 panel kit, which contains several ALL-related genes. The patient’s clinical and laboratory characteristics were collected from medical records from January to December 2019. Result: We observed gene copy number alteration in children with B-Cell ALL. PAX5 was the most commonly observed gene deletion, followed by CDKN21/2B, ETV6, IKZF1, BTG1, RB1, and PAR1 Region. Based on gene mutations, only the PAX5 had a significant association with the remission status of pediatric B-cell ALL (p-value <0.05; OR = 3.91). It showed that patients with PAX5 gene mutations have 3.9 times the risk of no remission and/or relapse compared to those without PAX5 gene mutations. Conclusion: Patients with mutations in the PAX5 gene have a higher chance of not achieving remission and/or experiencing relapse than those without such mutations. The MLPA method can be utilized for examining copy number alterations, which is valuable for achieving more precise stratification in diagnosis., Further research is needed to expand upon this finding. © (2024), (Asian Pacific Organization for Cancer Prevention). All rights reserved.
Acute Lymphoblastic Leukemia; CNA; MLPA; Pediatrics
Adolescent; Biomarkers, Tumor; Child; Child, Preschool; Cross-Sectional Studies; Cyclin-Dependent Kinase Inhibitor p15; DNA Copy Number Variations; Female; Follow-Up Studies; Humans; Ikaros Transcription Factor; Infant; Male; Multiplex Polymerase Chain Reaction; Neoplasm Proteins; PAX5 Transcription Factor; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Remission Induction; Retinoblastoma Binding Proteins; Ubiquitin-Protein Ligases; BTG1 protein, human; CDKN2B protein, human; cyclin dependent kinase inhibitor 2B; Ikaros transcription factor; IKZF1 protein, human; PAX5 protein, human; RB1 protein, human; retinoblastoma binding protein; transcription factor PAX5; tumor marker; tumor protein; ubiquitin protein ligase; adolescent; B cell acute lymphoblastic leukemia; child; copy
Dharmais Cancer Center Hospital, (244/KEPK/X/2022); Faculty of Medicine Universitas Indonesia, (KET-1201/UN2.F1/ETIK/PPM.00.02/2022)
The ethical aspects of this research were carefully considered and addressed. The Dharmais Cancer Center Hospital No.244/KEPK/X/2022 and Faculty of Medicine Universitas Indonesia KET-1201/UN2.F1/ETIK/PPM.00.02/2022 approved all human participant procedures. Informed consent was obtained from all participants before their involvement in the study. Additionally, appropriate measures were taken to en
Asian Pacific Organization for Cancer Prevention
15137368
39068576
Article
Q3
446
11920