Publikasi Scopus 2024 per tanggal 30 September 2024 (820 artikel)

Rustamadji P.; Wiyarta E.; Pramono M.; Maulanisa S.C.
Rustamadji, Primariadewi (55321572200); Wiyarta, Elvan (57221521342); Pramono, Meike (59132495800); Maulanisa, Sinta Chaira (58189295400)
55321572200; 57221521342; 59132495800; 58189295400
Response to Neoadjuvant Chemotherapy in Invasive Breast Cancer Predicted by CD4+, CD8+, and FOXP3+ Tumor-Infiltrating Lymphocytes
2024
Asian Pacific Journal of Cancer Prevention
25
5
1607
1613
6
0
Department of Anatomic Pathology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jakarta, Indonesia
Rustamadji P., Department of Anatomic Pathology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Wiyarta E., Department of Anatomic Pathology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Pramono M., Department of Anatomic Pathology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Maulanisa S.C., Department of Anatomic Pathology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jakarta, Indonesia
Background: Response to neoadjuvant chemotherapy (NC) in individuals with invasive breast cancer (IBC) must be monitored, and biomarkers are needed. NC can activate an anti-tumour immune response in its microenvironment, known as Tumor-infiltrating Lymphocytes (TIL). TIL components believed to have great potential as predictors are CD4+, CD8+, and FOXP3+ TIL. This study aims to explore TIL components that can potentially be predictive biomarkers of NC pathological responses. Methods: A sample size of 40 were analyzed based on the relationship between CD4+, CD8+, and FOXP3+ TIL expression with the Miller-Payne (MP) grading system. Age, tumour grade, PR, ER, Ki-67, and HER2 were also evaluated. CD4+, CD8+, and FOXP3+ TIL expressions were analayzed by IHC staining, while other data were collected from archives. Data was analyzed using univariate and multivariate analysis. Results: Univariate analysis showed a significant relationship between CD4+ TIL and MP (p<0.001), CD8+ and MP (p=0.004), and FOXP3 with MP (p<0.001). The simultaneous integration of the three biomarkers in one model was not good enough to be a predictive model. Therefore, an exploratory analysis was conducted by testing several alternative models that combined two of the three existing biomarkers. It turned out that CD4+ TIL in model 2 (CD4+CD8+) and FOXP3+ TIL in model 4 (CD8+FOXP3+) showed significant coefficient values. Moreover, all of the threshold coefficients in model 4 are significant. Conclusion: This study shows that CD4+, CD8+, and FOXP3+ TIL have promising potential as predictive biomarkers. In particular, FOXP3+ is dominant in predictive models of pathological response in patients with IBC. This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License.
CD4; CD8; chemotherapy response; FOXP3; predictor; prognosis
Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Female; Follow-Up Studies; Forkhead Transcription Factors; Humans; Lymphocytes, Tumor-Infiltrating; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; Prognosis; Tumor Microenvironment; antineoplastic agent; forkhead transcription factor; FOXP3 protein, human; tumor marker; adult; aged; breast ductal carcinoma; breast tumor; CD4+ T lymphocyte; CD8+ T lymphocyte; drug therapy; female; follow up; human; immunology; metabolism; middle aged; neoadjuvant therapy; pathology; procedures; prognosis; tumor associated leukocyte; tumor invasion; tumor microenvironment
National Agency for Research and Innovation via Publikasi Terindeks Internasional; Universitas Indonesia, UI; PUTI; Ministry of Research; Agencia Nacional de Investigación e Innovación, ANII; Direktorat Riset and Pengembangan, Universitas Indonesia, DRPM UI; Publikasi Terindeks Internasional, (NKB-193/UN2, RST/HKP.05.00/2022)
Funding text 1: This work was supported by grants from the Directorate of Research & Development Universitas Indonesia and the Ministry of Research/National Agency for Research and Innovation via Publikasi Terindeks Internasional (PUTI) Pascasarjana Q3 grant number NKB-193/UN2. RST/HKP.05.00/2022.; Funding text 2: Universitas Indonesia and the Ministry of Research/ National Agency for Research and
Asian Pacific Organization for Cancer Prevention
15137368
38809632
Article
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