Publikasi Scopus 2024 per tanggal 30 September 2024 (820 artikel)

Ginting Munte F.A.; Elen E.; Lelya O.; Rudiktyo E.; Prakoso R.; Lilyasari O.
Ginting Munte, Fatwiadi Apulita (58592657000); Elen, Elen (57196424259); Lelya, Olfi (57214125298); Rudiktyo, Estu (57736528400); Prakoso, Radityo (57192893243); Lilyasari, Oktavia (57192914838)
58592657000; 57196424259; 57214125298; 57736528400; 57192893243; 57192914838
Right ventricular fibrosis in adults with uncorrected secundum atrial septal defect and pulmonary hypertension: a cardiovascular magnetic resonance study with late gadolinium enhancement, native T1 and extracellular volume
2024
Frontiers in Cardiovascular Medicine
11
1395382
0
Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Division of Cardiovascular Imaging and Nuclear Cardiology, Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Division of Pediatric Cardiology and Congenital Heart Disease, Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Division of Echocardiography, Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia
Ginting Munte F.A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Elen E., Division of Cardiovascular Imaging and Nuclear Cardiology, Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Lelya O., Division of Pediatric Cardiology and Congenital Heart Disease, Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Rudiktyo E., Division of Echocardiography, Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Prakoso R., Division of Pediatric Cardiology and Congenital Heart Disease, Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Lilyasari O., Division of Pediatric Cardiology and Congenital Heart Disease, Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia
Introduction: Right ventricular (RV) fibrosis represents both adaptive and maladaptive responses to the overloaded RV condition. Its role in pulmonary hypertension (PH) associated with secundum atrial septal defect (ASD), which is the most common adult congenital heart disease (CHD), remains poorly understood. Methods: We enrolled 65 participants aged ≥18 years old with uncorrected secundum ASD who had undergone clinically indicated right heart catheterization (RHC), divided into the non-PH group (n = 7), PH group (n = 42), and Eisenmenger syndrome (ES) group (n = 16). We conducted cardiovascular magnetic resonance (CMR) studies with late gadolinium enhancement (LGE) imaging, native T1 mapping, and extracellular volume (ECV) measurement to evaluate the extent and clinical correlates of RV fibrosis. Results: LGE was present in 94% of the population and 86% of the non-PH group, mostly located at the right ventricular insertion point (RVIP) regions. LGE in the septal and inferior RV region was predominantly observed in the ES group compared to the other groups (p = 0.031 and p < 0.001, respectively). The mean LGE scores in the ES and PH groups were significantly higher than those in the non-PH group (3.38 ± 0.96 vs. 2.74 ± 1.04 vs. 1.57 ± 0.79; p = 0.001). The ES and PH groups had significantly higher degrees of interstitial RV fibrosis compared to those in the non-PH group, indicated by native T1 (1,199.9 ± 68.9 ms vs. 1,131.4 ± 47.8 ms vs. 1,105.4 ± 44.0 ms; p < 0.001) and ECV (43.6 ± 6.6% vs. 39.5 ± 4.9% vs. 39.4 ± 5.8%; p = 0.037). Additionally, native T1 significantly correlated with pulmonary vascular resistance (r = 0.708, p < 0.001), RV ejection fraction (r = −0.468, p < 0.001) and peripheral oxygen saturation (r = −0.410, p = 0.001). Conclusion: In patients with uncorrected secundum ASD, RV fibrosis may occur before the development of PH and progressively intensify alongside the progression of PH severity. A higher degree of RV fibrosis, derived from CMR imaging, correlates with worse hemodynamics, RV dysfunction, and poorer clinical conditions. 2024 Ginting Munte, Elen, Lelya, Rudiktyo, Prakoso and Lilyasari.
extracellular volume; late gadolinium enhancement; native T1; pulmonary hypertension; right ventricular fibrosis; secundum atrial septal defect
biological marker; contrast medium; creatinine; gadolinium; gadoterate meglumine; sodium chloride; adult; area under the curve; Article; body weight; cardiovascular magnetic resonance; congenital heart disease; diagnostic test accuracy study; disease severity; echocardiography; Eisenmenger complex; female; flow rate; heart atrium septum defect; heart catheterization; heart hemodynamics; heart left ventricle ejection fraction; heart left ventricle enddiastolic volume; heart left ventricle endsystolic volume; heart muscle fibrosis; heart output; heart rate; heart right ventricle ejection fraction; heart ventricular pressure; hematocrit; human; interventricular septum; late gadolinium enhancement imaging; lung artery pressure; lung flow volume curve; lung vascular resistance; major clinical s
Frontiers Media SA
2297055X
Article
Q2
863
5560