Publikasi Scopus 2024 per tanggal 30 September 2024 (820 artikel)

Hanafy D.A.; Willim H.A.; Suwatri W.T.; Sani A.A.; Khouw H.; Susanti E.I.; Sugisman
Hanafy, Dudy Arman (57220157579); Willim, Herick Alvenus (57223180510); Suwatri, Widya Trianita (58569332600); Sani, Alvin Ariyanto (57209881028); Khouw, Hengky (59147659600); Susanti, Eunike Ita (59215411600); Sugisman (57224162065)
57220157579; 57223180510; 58569332600; 57209881028; 59147659600; 59215411600; 57224162065
Efficacy of N-acetylcysteine for Prevention of Postoperative Atrial Fibrillation Following Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
2024
Reviews in Cardiovascular Medicine
25
7
0
Department of Cardiothoracic and Vascular Surgery, Division of Adult Cardiac Surgery, National Cardiovascular Center Harapan Kita, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia
Hanafy D.A., Department of Cardiothoracic and Vascular Surgery, Division of Adult Cardiac Surgery, National Cardiovascular Center Harapan Kita, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Willim H.A., Department of Cardiothoracic and Vascular Surgery, Division of Adult Cardiac Surgery, National Cardiovascular Center Harapan Kita, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Suwatri W.T., Department of Cardiothoracic and Vascular Surgery, Division of Adult Cardiac Surgery, National Cardiovascular Center Harapan Kita, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Sani A.A., Department of Cardiothoracic and Vascular Surgery, Division of Adult Cardiac Surgery, National Cardiovascular Center Harapan Kita, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Khouw H., Department of Cardiothoracic and Vascular Surgery, Division of Adult Cardiac Surgery, National Cardiovascular Center Harapan Kita, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Susanti E.I., Department of Cardiothoracic and Vascular Surgery, Division of Adult Cardiac Surgery, National Cardiovascular Center Harapan Kita, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Sugisman, Department of Cardiothoracic and Vascular Surgery, Division of Adult Cardiac Surgery, National Cardiovascular Center Harapan Kita, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia
Background: As the prevalence of coronary artery disease rises, the demand for coronary artery bypass grafting (CABG) increases. A common complication after CABG is postoperative atrial fibrillation (POAF), which is linked to adverse clinical outcomes. N-acetylcysteine (NAC), an antioxidant, may mitigate oxidative stress and reduce the incidence of POAF. This meta-analysis aims to investigate the efficacy of NAC in preventing POAF after CABG. Methods: The meta-analysis was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. We systematically searched multiple databases, including PubMed, Cochrane Library, ProQuest, and ScienceDirect, to identify relevant randomized controlled trials (RCTs). The intervention groups received perioperative NAC therapy, while the control groups received a placebo. The outcomes assessed were POAF incidence, all-cause mortality, and hospital length of stay (LOS). Review Manager 5.3 was used to conduct the meta-analysis. Results: Eleven RCTs involving 648 patients were included. The NAC group comprised 326 patients, while the control group comprised 322 patients. In the pooled analysis, patients in the NAC group had a significantly lower incidence of POAF (odds ratios (OR) = 0.57; 95% confidence intervals (CI) = 0.33 to 0.97; p = 0.04) and a shorter hospital LOS (weighted mean differences (WMD) = –0.66; 95% CI = –1.22 to –0.10; p = 0.02) compared to the control group. However, there was no significant difference in all-cause mortality. Conclusions: The perioperative administration of NAC can effectively reduce the incidence of POAF and hospital LOS in CABG patients. However, larger RCTs are needed to confirm these findings. Copyright: © 2024 The Author(s).
coronary artery bypass grafting; N-acetylcysteine; postoperative atrial fibrillation; surgery
acetylcysteine; anesthesia induction; atrial fibrillation; cardioplegia; coronary artery bypass graft; data extraction; drug efficacy; genetic heterogeneity; hospitalization; human; length of stay; meta analysis; mortality; outcome assessment; oxidative stress; perioperative period; postoperative atrial fibrillation; prevalence; randomized controlled trial (topic); Review; systematic review; visual analog scale
IMR Press Limited
15306550
Review
Q2
518
10435