Publikasi Scopus FKUI Tahun 2010 s/d 2020 (data Per 3 Februari 2021)

Ndraha S., Hasan I., Simadibrata M.
The effect of L-ornithine L-aspartate and branch chain amino acids on encephalopathy and nutritional status in liver cirrhosis with malnutrition.
Acta medica Indonesiana
Department of Internal Medicine, Faculty of Medicine, University of Indonesia - Dr. Cipto Mangunkusumo Hospital, Jl. Diponegoro no. 71, Jakarta Pusat 10430, Indonesia.
Ndraha, S., Department of Internal Medicine, Faculty of Medicine, University of Indonesia - Dr. Cipto Mangunkusumo Hospital, Jl. Diponegoro no. 71, Jakarta Pusat 10430, Indonesia.; Hasan, I.; Simadibrata, M.
to determine the effect of L-ornithine-L-aspartate (LOLA) together with the nutritional improvement and branched chain amino acids (BCAAs) substitution, on encephalopathy in liver cirrhosis with malnutrition. liver cirrhosis patients visited Cipto mangunkusumo Hospital in June-October 2009 were evaluated by critical flicker frequency (CFF) test. Encephalopathy is defined when CFF <39 Hz. Nutritional status is measured by the mid-arm muscle circumference (MAMC) and is stated as malnutrition when MAMC <15%. All subjects who fulfilled the inclusion criteria received education for adequate calories and protein intake, and then they were be divided into 2 groups by randomization. One group was given LOLA granules 3 x 6 g/d for 2 weeks, while another group was not. Then their prealbumin and CFF test were measured again. Statistical analysis conducted for this double blind randomized clinical trial was independent student t test. there were 34 liver cirrhosis patients fit the inclusion criteria, and by randomization 17 subjects were put into group A (received LOLA) and 17 subjects into group B (without LOLA). Statistical analysis obtained the statistically significant (p=0,016) of increasing of the mean CFF value in group A (2.41 ± 1.6 Hz) compared to group B (0.67 ± 2.3 Hz). However, there was not significant increasing of prealbumin level in group A compared to group B (1 ± 1.3 mg/dL vs 1.2 ± 1.4 mg/dL, respectively (p=0,59). Furthermore, after 2 weeks of treatment there was no significant increase of ureum and creatinine level in both groups (4 ± 0.5 mg/dL vs 9.3 ± 1.3 mg/dL, (p=0.4) for ureum, -0.1 (0.1) mg/dL vs 0.1 ± 0.1 mg/dL, (p=0.3) for creatinine. minimal hepatic encephalopathy with malnutrition can be given a diet of 35-40 cal/kgBW and 1.5 g protein/kgBW including BCAA substitution to improve nutritional status, and LOLA granules can be given to improve encephalopathy.
albuminoid; ammonia; branched chain amino acid; dipeptide; ornithylaspartate; adult; aged; article; blood; clinical trial; controlled clinical trial; controlled study; double blind procedure; female; genetics; hepatic encephalopathy; human; liver cirrhosis; male; malnutrition; metabolism; middle aged; nutritional status; protein intake; randomized controlled trial; Adult; Aged; Albumins; Amino Acids, Branched-Chain; Ammonia; Dietary Proteins; Dipeptides; Double-Blind Method; Female; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Male; Malnutrition; Middle Aged; Nutritional Status; Young Adult

Unit Riset FKUI/Medical Research Unit
Gedung IMERI Tower Riset lt. 9, Jl. Salemba Raya No. 6, Jakarta Pusat, 10430
Telp. : +62 21 29189160 (ext. 201912)
E-mail :

© {2022} Riset & Pengabdian Masyarakat. All Rights Reserved.