Publikasi Scopus FKUI Tahun 2010 s/d 2020 (data Per 3 Februari 2021)

Schrijver B., Dijkstra D.J., Borggreven N.V., La Distia Nora R., Huijser E., Versnel M.A., van Hagen P.M., Joosten S.A., Trouw L.A., Dik W.A.
36345029700;57211961987;57200880092;57218644170;57201635735;7004145797;57210765646;6601983679;6602464590;6603280038;
Inverse correlation between serum complement component C1q levels and whole blood type-1 interferon signature in active tuberculosis and QuantiFERON-positive uveitis: implications for diagnosis
2020
Clinical and Translational Immunology
9
10
e1196
Department of Immunology, Laboratory Medical Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands; Department of Ophthalmology, Faculty of Medicine, University of Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Internal Medicine, Division Clinical Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands
Schrijver, B., Department of Immunology, Laboratory Medical Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Dijkstra, D.J., Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands; Borggreven, N.V., Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands; La Distia Nora, R., Department of Ophthalmology, Faculty of Medicine, University of Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Huijser, E., Department of Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Versnel, M.A., Department of Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; van Hagen, P.M., Department of Immunology, Laboratory Medical Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, Department of Internal Medicine, Division Clinical Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands; Joosten, S.A., Department of Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands; Trouw, L.A., Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands; Dik, W.A., Department of Immunology, Laboratory Medical Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands, Department of Internal Medicine, Division Clinical Immunology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands
Objectives: To examine the relation between serum C1q levels and blood type-1 interferon signature (type-1 IFN signature) in active pulmonary tuberculosis (APTB) and to determine whether combined measurement of serum C1q and type-1 IFN signature may add to the diagnosis of QuantiFERON-positive (QFT+) patients with uveitis of unknown cause. Methods: C1q was determined (ELISA) in serum from two distinct Indonesian cohorts, and in total, APTB (n = 72), QFT+ uveitis of unknown aetiology (n = 58), QFT− uveitis (n = 51) patients and healthy controls (HC; n = 73) were included. The type-1 IFN signature scores were previously determined. Results: Serum C1q was higher in APTB than HC (P < 0.001). APTB patients with uveitis had higher serum C1q than APTB patients without uveitis (P = 0.0207). Serum C1q correlated inversely with type-1 IFN signature scores in APTB (P = 0.0036, r2 = 0.3526), revealing that these biomarkers for active TB disease can be mutually exclusive. Stratification of QFT+ patients with uveitis of unknown cause, by serum C1q and type-1 IFN signature, yielded four groups with different likelihood of suffering from active TB uveitis. Conclusion: Serum C1q is elevated in APTB, especially in those cases with uveitis. We propose that combined measurement of blood type-1 IFN signature and serum C1q may provide added value in the diagnosis of active TB disease. Combined measurement of type-1 IFN signature and serum C1q in QFT+ patients without signs of active TB disease, but suffering from uveitis of unknown cause, may be of help to identify cases with low or high likelihood of having active TB uveitis, which may facilitate clinical management decisions. © 2020 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.
C1q; complement; extrapulmonary tuberculosis; QuantiFERON; type-1 interferon signature; uveitis
complement component C1q; interferon; adult; Article; autoimmune disease; cohort analysis; complement blood level; controlled study; disease association; enzyme linked immunosorbent assay; female; human; Indonesian; lung tuberculosis; major clinical study; male; priority journal; Sjoegren syndrome; sputum smear; systemic lupus erythematosus; systemic sclerosis; uveitis; Youden index
John Wiley and Sons Inc
20500068
Article
Q1

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