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Publikasi Scopus FKUI 2021 per tanggal 31 Agustus 2021 (582 artikel)
Publikasi Scopus FKUI 2021 per tanggal 31 Agustus 2021 (582 artikel)
Visceral adiposity, subcutaneous adiposity, and severe coronavirus disease-2019 (COVID-19): Systematic review and meta-analysis
2021
Clinical Nutrition ESPEN
43
163
168
4
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104309308&doi=10.1016%2fj.clnesp.2021.04.001&partnerID=40&md5=e8122f7c8b69f82d927a6b4a78d83d7a
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Balaraja General Hospital, Tangerang, Indonesia; Division of Plastic, Reconstructive and Aesthetic, Department of Surgery, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia; Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia
Background and aims: Body mass index (BMI) has previously been shown to increase mortality and disease severity in patients with COVID-19, but the pooled effect estimate was heterogeneous. Although BMI is widely used as an indicator, it cannot distinguish visceral from subcutaneous fat. This systematic review and meta-analysis aimed to investigate the association between visceral adiposity, subcutaneous fat, and severe COVID-19. Methods: We performed a systematic literature search using the databases: PubMed, Embase, and EuropePMC. Data on visceral fat area (VTA), subcutaneous fat area (SFA), and total fat area (TFA) were collected. The outcome of interest was severe COVID-19. We used a REML random-effects model to pool the mean differences and odds ratio (OR). Results: There were 5 studies comprising of 539 patients. Patients with severe COVID-19 have a higher VTA (mean difference 41.7 cm2 [27.0, 56.4], p < 0.001; I2: 0%) and TFA (mean difference 64.6 cm2 [26.2, 103.1], p = 0.001; I2: 0%). There was no significant difference in terms of SFA between patients with severe and non-severe COVID-19 (mean difference 9.3 cm2 [-4.9, 23.4], p = 0.199; I2: 1.2%). Pooled ORs showed that VTA was associated with severe COVID-19 (OR 1.9 [1.1, 2.2], p = 0.002; I2: 49.3%). Conclusion: Visceral adiposity was associated with increased COVID-19 severity, while subcutaneous adiposity was not. Prospero id: CRD42020215876. © 2021 European Society for Clinical Nutrition and Metabolism
Article; artificial ventilation; body composition; body mass; cardiovascular disease; coronavirus disease 2019; critical illness; diabetes mellitus; disease exacerbation; disease severity; human; hypertension; intensive care unit; intra-abdominal fat; meta analysis; mortality; Newcastle-Ottawa scale; nonhuman; obesity; observational study; respiratory tract intubation; Severe acute respiratory syndrome coronavirus 2; shock; subcutaneous fat; systematic review; abdominal obesity; aged; body mass; comorbidity; complication; female; intra-abdominal fat; male; metabolism; middle aged; severity of illness index; subcutaneous fat; Adiposity; Aged; Body Mass Index; Comorbidity; COVID-19; Female; Humans; Intra-Abdominal Fat; Male; Middle Aged; Obesity; Obesity, Abdominal; SARS-CoV-2; Severity of I
Elsevier Ltd
24054577
34024509
Article
Q2
659
7601